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stem cell therapy low back pain

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https://www.readbyqxmd.com/read/29705378/intervertebral-disc-regeneration-from-cell-therapy-to-the-development-of-novel-bioinspired-endogenous-repair-strategies
#1
Johann Clouet, Marion Fusellier, Anne Camus, Catherine Le Visage, Jérôme Guicheux
Low back pain (LBP), frequently associated with intervertebral disc (IVD) degeneration, is a major public health concern. LBP is currently managed by pharmacological treatments and, if unsuccessful, by invasive surgical procedures, which do not counteract the degenerative process. Considering that IVD cell depletion is critical in the degenerative process, the supplementation of IVD with reparative cells, associated or not with biomaterials, has been contemplated. Recently, the discovery of reparative stem/progenitor cells in the IVD has led to increased interest in the potential of endogenous repair strategies...
April 26, 2018: Advanced Drug Delivery Reviews
https://www.readbyqxmd.com/read/29687490/quantitative-mri-correlates-with-histological-grade-in-a-percutaneous-needle-injury-mouse-model-of-disc-degeneration
#2
Matthew Piazza, Sun H Peck, Sarah E Gullbrand, Justin R Bendigo, Toren Arginteanu, Yejia Zhang, Harvey E Smith, Neil R Malhotra, Lachlan J Smith
Low back pain due to disc degeneration is a major cause of morbidity and health care expenditures worldwide. While stem cell-based therapies hold promise for disc regeneration, there is an urgent need to develop improved in vivo animal models to further develop and validate these potential treatments. The objectives of this study were to characterize a percutaneous needle injury model of intervertebral disc degeneration in the mouse caudal spine, and compare two non-invasive quantitative imaging techniques, microcomputed tomography and magnetic resonance imaging (MRI), as effective measures of disc degeneration in this model...
April 24, 2018: Journal of Orthopaedic Research: Official Publication of the Orthopaedic Research Society
https://www.readbyqxmd.com/read/29555463/genipin-cross-linked-type-ii-collagen-chondroitin-sulfate-composite-hydrogel-like-cell-delivery-system-induces-differentiation-of-adipose-derived-stem-cells-and-regenerates-degenerated-nucleus-pulposus
#3
Xiaopeng Zhou, Jingkai Wang, Weijing Fang, Yiqing Tao, Tengfei Zhao, Kaishun Xia, Chengzhen Liang, Jianming Hua, Fangcai Li, Qixin Chen
Nucleus pulposus (NP) degeneration is usually the origin of intervertebral disc degeneration and consequent lower back pain. Although adipose-derived stem cell (ADSC)-based therapy is regarded to be promising for the treatment of degenerated NP, there is a lack of viable cell carriers to transplant ADSCs into the NP while maintaining cell function. In this study, we developed a type II collagen/chondroitin sulfate (CS) composite hydrogel-like ADSC (CCSA) delivery system with genipin as the cross-linking agent...
March 16, 2018: Acta Biomaterialia
https://www.readbyqxmd.com/read/29189572/immunomodulation-of-human-mesenchymal-stem-stromal-cells-in-intervertebral-disc-degeneration-insights-from-a-proinflammatory-degenerative-ex-vivo-model
#4
Graciosa Q Teixeira, Catarina Leite Pereira, Joana R Ferreira, André F Maia, Maria Gomez-Lazaro, Mário A Barbosa, Cornelia Neidlinger-Wilke, Raquel M Goncalves
STUDY DESIGN: Ex vivo experimental study. OBJECTIVE: To investigate the effect of proinflammatory/degenerative intervertebral disc (IVD) microenvironment on the regenerative and immunomodulatory behavior of mesenchymal stem/stromal cells (MSCs), using an ex vivo model from bovine origin. SUMMARY OF BACKGROUND DATA: Low back pain (LBP) is a cause of disability worldwide, most frequently associated with IVD degeneration and inflammation, and characterized by increased levels of inflammatory mediators, often disregarded...
November 17, 2017: Spine
https://www.readbyqxmd.com/read/28925497/the-feasibility-of-the-cd271-and-cd271-mesenchymal-stromal-cell-enrichment-toward-nucleus-pulposus-like-cells
#5
Katarzyna Jezierska-Wozniak, Monika Barczewska, Aleksandra Habich, Pawel Wojtacha, Wanda Badowska, Wojciech Maksymowicz, Joanna Wojtkiewicz
INTRODUCTION: Factors promoting nerve cell ingrowth are considered responsible for chronic back pain resulting from the intervertebral disc degeneration (IDD). One of the recent exploratory IDD treatments is stem cell transplantation therapy. The CD271 (low-affinity nerve growth factor receptor) has been identified as a mark-er of the most homogeneous mesenchymal stem cell (MSC) subset. It is capable of promoting differentiation along adipogenic, osteogenic and chondrogenic lineages and producing significantly higher levels of cytokines as compared to the total population of plastic adherence-mesenchymal stem cells (PA-MSCs)...
2017: Folia Histochemica et Cytobiologica
https://www.readbyqxmd.com/read/28546769/treatment-of-chronic-low-back-pain-new-approaches-on-the-horizon
#6
REVIEW
Nebojsa Nick Knezevic, Shane Mandalia, Jennifer Raasch, Ivana Knezevic, Kenneth D Candido
Back pain is the second leading cause of disability among American adults and is currently treated either with conservative therapy or interventional pain procedures. However, the question that remains is whether we, as physicians, have adequate therapeutic options to offer to the patients who suffer from chronic low back pain but fail both conservative therapy and interventional pain procedures before they consider surgical options such as discectomy, disc arthroplasty, or spinal fusion. The purpose of this article is to review the potential novel therapies that are on the horizon for the treatment of chronic low back pain...
2017: Journal of Pain Research
https://www.readbyqxmd.com/read/28350945/intervertebral-disk-degeneration-and-repair
#7
REVIEW
James Dowdell, Mark Erwin, Theodoe Choma, Alexander Vaccaro, James Iatridis, Samuel K Cho
Intervertebral disk (IVD) degeneration is a natural progression of the aging process. Degenerative disk disease (DDD) is a pathologic condition associated with IVD that has been associated with chronic back pain. There are a variety of different mechanisms of DDD (genetic, mechanical, exposure). Each of these pathways leads to a final common result of unbalancing the anabolic and catabolic environment of the extracellular matrix in favor of catabolism. Attempts have been made to gain an understanding of the process of IVD degeneration with in Vitro studies...
March 1, 2017: Neurosurgery
https://www.readbyqxmd.com/read/28011039/the-direction-of-human-mesenchymal-stem-cells-into-the-chondrogenic-lineage-is-influenced-by-the-features-of-hydrogel-carriers
#8
A Hansson, A Wenger, H Barreto Henriksson, S Li, B R Johansson, H Brisby
Low back pain is a major public health issue in the Western world, one main cause is believed to be intervertebral disc (IVD) degeneration. To halt/diminish IVD degeneration, cell therapy using different biomaterials e.g. hydrogels as cell carriers has been suggested. In this study, two different hydrogels were examined (in vitro) as potential cell carriers for human mesenchymal stem cells (hMSCs) intended for IVD transplantation. The aim was to investigate cell-survival and chondrogenic differentiation of hMSCs when cultured in hydrogels Puramatrix(®) or Hydromatrix(®) and potential effects of stimulation with growth hormone (GH)...
February 2017: Tissue & Cell
https://www.readbyqxmd.com/read/28002916/mesenchymal-stem-cells-for-intervertebral-disc-regeneration
#9
G Vadalà, F Russo, L Ambrosio, R Papalia, V Denaro
Low back pain (LBP) is one of the most common disabling symptoms affecting the adult population throughout the industrialized world. The main cause underlying this condition is intervertebral disc degeneration (IDD), which is characterized by progressive decrease of the proteoglycan content within the nucleus pulposus (NP), leading to disc dehydration and loss of its morpho-functional and biomechanical properties. To date, LBP treatment is based upon conservative and invasive procedures which are not capable of restoring the degenerative alterations of the disc, as they only help relieve the symptoms and/or slow down disc degeneration and are, nonetheless, characterized by significant comorbidities, costs and secondary risks...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/27586197/strategies-in-regenerative-medicine-for-intervertebral-disc-repair-using-mesenchymal-stem-cells-and-bioscaffolds
#10
REVIEW
James Melrose
The intervertebral disc (IVD) is a major weight bearing structure that undergoes degenerative changes with aging limiting its ability to dissipate axial spinal loading in an efficient manner resulting in the generation of low back pain. Low back pain is a number one global musculoskeletal disorder with massive socioeconomic impact. The WHO has nominated development of mesenchymal stem cells and bioscaffolds to promote IVD repair as primary research objectives. There is a clear imperative for the development of strategies to effectively treat IVD defects...
October 2016: Regenerative Medicine
https://www.readbyqxmd.com/read/27585696/intra-discal-injection-of-autologous-hypoxic-cultured-bone-marrow-derived-mesenchymal-stem-cells-in-five-patients-with-chronic-lower-back-pain-a-long-term-safety-and-feasibility-study
#11
Christian Elabd, Christopher J Centeno, John R Schultz, Gregory Lutz, Thomas Ichim, Francisco J Silva
BACKGROUND: Chronic low back pain due to disc degeneration represents a major social and economic burden worldwide. The current standard of care is limited to symptomatic relief and no current approved therapy promotes disc regeneration. Bone marrow-derived mesenchymal stem cells (MSCs) are easily accessible and well characterized. These MSCs are multipotent and exhibit great tissue regenerative potential including bone, cartilage, and fibrous tissue regeneration. The use of this cell-based biologic for treating protruding disc herniation and/or intervertebral disc degeneration is a promising therapeutic strategy, due to their known regenerative, immuno-modulatory and anti-inflammatory properties...
September 1, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27278552/a-genome-wide-analysis-of-alternative-splicing-events-during-the-osteogenic-differentiation-of-human-cartilage-endplate-derived-stem-cells
#12
Jin Shang, Honggang Wang, Xin Fan, Lei Shangguan, Huan Liu
Low back pain is a prevalent disease, which leads to suffering and disabilities in a vast number of individuals. Degenerative disc diseases are usually the underlying causes of low back pain. However, the pathogenesis of degenerative disc diseases is highly complex and difficult to determine. Current therapies for degenerative disc diseases are various. In particular, cell-based therapies have proven to be effective and promising. Our research group has previously isolated and identified the cartilage endplate‑derived stem cells...
August 2016: Molecular Medicine Reports
https://www.readbyqxmd.com/read/26953666/cell-based-therapies-for-lumbar-discogenic-low-back-pain-systematic-review-and-single-arm-meta-analysis
#13
Tao Wu, Hai-Xin Song, Yan Dong, Jian-Hua Li
STUDY DESIGN: A systematic review and single-arm meta-analysis of clinical trials. OBJECTIVE: To assess the efficacy of mesenchymal stem cells or chondrocyte in patients with discogenic low back pain. SUMMARY OF BACKGROUND DATA: There is no previous review evaluated the efficacy of mesenchymal stem cell or chondrocyte therapy in adults with discogenic low back pain. METHODS: A comprehensive literature search was conducted on PubMed, Ovid MEDLINE, Ovid EMBASE, EBSCO, and Web of Science from database inception through on September 10th, 2015...
January 1, 2018: Spine
https://www.readbyqxmd.com/read/26880958/multipotent-mesenchymal-stem-cell-treatment-for-discogenic-low-back-pain-and-disc-degeneration
#14
REVIEW
Jeffrey Zeckser, Michael Wolff, Jason Tucker, Josh Goodwin
Low back pain with resultant loss of function, decreased productivity, and high economic costs is burdensome for both the individual and the society. Evidence suggests that intervertebral disc pathology is a major contributor to spine-related pain and degeneration. When commonly used conservative therapies fail, traditional percutaneous or surgical options may be beneficial for pain relief but are suboptimal because of their inability to alter disc microenvironment catabolism, restore disc tissue, and/or preserve native spine biomechanics...
2016: Stem Cells International
https://www.readbyqxmd.com/read/26835326/mesenchymal-stem-cells-potential-application-in-intervertebral-disc-regeneration
#15
REVIEW
Aiqun Wei, Bojiang Shen, Lisa Williams, Ashish Diwan
Chronic low back pain is one of the leading public health problems in developed countries. Degeneration of the intervertebral disc (IVD) is a major pathological process implicated in low back pain, which is characterized by cellular apoptosis and senescence with reduced synthesis of extracellular matrix (ECM). Currently, there is no clinical therapy targeting the reversal of disc degeneration. Recent advances in cellular and molecular biology have provided an exciting approach to disc regeneration that focuses on the delivery of viable cells to the degenerative disc...
April 2014: Translational Pediatrics
https://www.readbyqxmd.com/read/26805824/cell-therapy-using-bone-marrow-derived-stem-cell-overexpressing-bmp-7-for-degenerative-discs-in-a-rat-tail-disc-model
#16
Jen-Chung Liao
Degenerative discs can cause low back pain. Cell-based transplantation or growth factors therapy have been suggested as a strategy to stimulate disc regeneration. Bone marrow-derived mesenchymal stem cells (BMDMSC) containing bone morphogenetic protein-7 (BMP-7) gene were constructed. We evaluated the effectiveness of these BMP-7 overexpressing cells on degenerative discs in rat tails. In vitro and in vivo studies were designed. In the first stage, the rats were divided into two group according to discs punctured by different needle gauges (18 gauge and 22 gauge)...
January 22, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/26342641/advances-in-biological-therapy-for-nucleus-pulposus-regeneration
#17
REVIEW
P Priyadarshani, Y Li, L Yao
OBJECTIVE: The intervertebral disc (IVD) is composed of the external annulus fibrosus (AF) and the inner gel-like center, the nucleus pulposus (NP). The elastic NP can function to relieve stress and maintain IVD function by distributing hydraulic pressure evenly to annulus and endplate. Degeneration of the NP, which leads to increased death of NP cells, the loss of proteoglycan (PG), and aberrant gene expression, may result in an overall alteration of the biomechanics of the spinal column and cause low back pain...
February 2016: Osteoarthritis and Cartilage
https://www.readbyqxmd.com/read/26118125/umbilical-cord-mesenchymal-stem-cells-in-neurological-disorders-a-clinical-study
#18
Xingyu Miao, Xiaoying Wu, Wei Shi
We investigated the intrathecally administrated unbilical cord mesenchymal stem cells (UC-MSCs) by lumbar puncture and assessed the technical difficulties and effects in various neurological conditions. One hundred patients underwent subarachnoid placement of UC-MSCs between December 2006 and May 2010 in the Affiliated Hospital of Medicine. Technical difficulties in patients in the form of localization of subarachnoid space, number of attempts, and post-procedural complications were evaluated. Functional evaluation was done using Hauser Ambulation Index (HAI) by the stem cell transplant team on a regular basis...
April 2015: Indian Journal of Biochemistry & Biophysics
https://www.readbyqxmd.com/read/26074979/cell-based-therapies-used-to-treat-lumbar-degenerative-disc-disease-a-systematic-review-of-animal-studies-and-human-clinical-trials
#19
REVIEW
David Oehme, Tony Goldschlager, Peter Ghosh, Jeffrey V Rosenfeld, Graham Jenkin
Low back pain and degenerative disc disease are a significant cause of pain and disability worldwide. Advances in regenerative medicine and cell-based therapies, particularly the transplantation of mesenchymal stem cells and intervertebral disc chondrocytes, have led to the publication of numerous studies and clinical trials utilising these biological therapies to treat degenerative spinal conditions, often reporting favourable outcomes. Stem cell mediated disc regeneration may bridge the gap between the two current alternatives for patients with low back pain, often inadequate pain management at one end and invasive surgery at the other...
2015: Stem Cells International
https://www.readbyqxmd.com/read/26059030/adipose-derived-stem-cells-improve-the-viability-of-nucleus-pulposus-cells-in-degenerated-intervertebral-discs
#20
Keran Song, Tao Gu, Feng Shuang, Jiaguang Tang, Dongfeng Ren, Jiang Qin, Shuxun Hou
Patients with degenerative disc disease (DDD) experience serious clinical symptoms, including chronic low back pain. A series of therapies have been developed to treat DDD, including physical therapy and surgical treatment. However, the therapeutic effect of such treatments has remained insufficient. Recently, stem cell‑based therapy, in which stem cells are injected into the nucleus pulposus in degenerated intervertebral disc tissue, has appeared to be effective in the treatment of DDD. In the present study, the effect of adipose‑derived stem cells on degenerated nucleus pulposus cells was investigated using a co‑culture system to evaluate the biological activity of degenerated nucleus pulposus cells...
September 2015: Molecular Medicine Reports
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