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Thyroid nodule

Naykky Singh Ospina, Ana Castaneda-Guarderas, Russell Ward, Juan P Brito, Spyridoula Maraka, Claudia Zeballos Palacios, Kathleen J Yost, Diana S Dean, Victor M Montori
PURPOSE: Fine-needle aspiration biopsy of the thyroid is an increasingly common outpatient procedure. Patients are counseled about the indications and risks of this procedure and informed consent is obtained. We aimed to assess the extent to which patients acquired necessary knowledge during this process. METHODS: Survey study conducted in a thyroid nodule clinic at a referral center. Adult patients who had just undergone a thyroid biopsy were asked to complete a survey, including eight questions regarding the indications and potential outcomes of thyroid biopsy...
June 16, 2018: Endocrine
Thao T Nguyen, Natascha G E Lange, Anne L Nielsen, Anders Thomassen, Helle Døssing, Christian Godballe, Max Rohde
PURPOSE: To examine whether addition of 18 F-fluoro-deoxy-glucose positron emission tomography/computed tomography (FDG-PET/CT) to fine needle aspiration biopsy (FNAB) would improve prediction of thyroid cancer in patients with FNAB-derived follicular neoplasm or atypia, classified according to focal, multifocal, diffuse, or no FDG uptake. MATERIALS AND METHODS: Consecutive patients with FNAB-derived follicular neoplasm or atypia planned for surgery from September 2013 to March 2016 were prospectively included and considered for analysis...
June 16, 2018: European Archives of Oto-rhino-laryngology
Hui Tan, Jun Chen, Yi Ling Zhao, Jin Huan Liu, Liang Zhang, Chang Sheng Liu, Dongjie Huang
RATIONALE AND OBJECTIVES: This study aimed to preliminarily investigate the feasibility of intravoxel incoherent motion (IVIM) theory in the differential diagnosis of benign and malignant thyroid nodules. MATERIALS AND METHODS: Forty-five patients with 56 confirmed thyroid nodules underwent preoperative routine magnetic resonance imaging and IVIM diffusion-weighted imaging. The histopathologic diagnosis was confirmed by surgery. Apparent diffusion coefficient (ADC), perfusion fraction f, diffusivity D, and pseudo-diffusivity D* were quantified...
June 13, 2018: Academic Radiology
Juan P Brito, Jae Hoon Moon, Rebecca Zeuren, Sung Hye Kong, Yeo Koon Kim, Nicole M Iñiguez-Ariza, June Young Choi, Kyu Eun Lee, Ji-Hoon Kim, Ian Hargraves, Victor Bernet, Victor Montori, Young Joo Park, R Michael Tuttle
BACKGROUND: The 2015 American Thyroid Association guidelines recognize active surveillance as an alternative to immediate surgery in patients with papillary microcarcinomas (PMCs). As a way to incorporate active surveillance as one of the management options for patients with PMCs, we describe the development and initial testing of a tool to support conversations between clinicians and patients with PMCs considering treatment options. METHODS: Thyroid Cancer Treatment Choice was developed using an iterative process based on the principles of interaction, design and participatory action research...
June 15, 2018: Thyroid: Official Journal of the American Thyroid Association
Zhe Mo, Guangming Mao, Wenming Zhu, Xiaofeng Wang, Xiaoming Lou, Gangqiang Ding
OBJECTIVE: To assess the prevalence of thyroid nodules and explore the risk factors for thyroid nodules among the community residents in Zhejiang Province. METHODS: The residents of twenty-two communities in Zhejiang Province were selectedwith stratified cluster sampling. The cross-sectional survey includes questionnaire, examination on thyroid. The prevalence and related factors of thyroid nodules was described, and the possible risk factors for thyroid nodules was analyzed with logistic regression...
November 2017: Wei Sheng Yan Jiu, Journal of Hygiene Research
Zunfu Ke, Yihao Liu, Yunjian Zhang, Jie Li, Ming Kuang, Sui Peng, Jinyu Liang, Shuang Yu, Lei Su, Lili Chen, Cong Sun, Bin Li, Jessica Cao, Weiming Lv, Haipeng Xiao
Differentiation of benign and malignant thyroid nodules is crucial for clinical management. Here, we explored the efficacy of next‑generation sequencing (NGS) in predicting the classification of benign and malignant thyroid nodules and lymph node metastasis status, and simultaneously compared the results with ultrasound (US). Thyroline was designed to detect 15 target gene mutations and 2 fusions in 98 formalin‑fixed, paraffin‑embedded (FFPE) tissues, including those from 82 thyroid cancer (TC) patients and 16 patients with benign nodules...
June 14, 2018: Oncology Reports
Yasemin Ucal, Murat Eravci, Fatma Tokat, Mete Duren, Umit Ince, Aysel Ozpinar
Introduction: Fine Needle Aspiration Biopsy (FNAB) allows the cytological differentiation of benign and malignant thyroid nodules. However, the method itself is not adequate in determining some cases. For example, the diagnosis of Follicular Variant Papillary Thyroid Carcinoma (FV-PTC) can be challenging. In the current study we investigate the protein profiles of FV-PTC and classical variant PTC (CV-PTC) with no lymph node metastasis and compare it with benign thyroid tissue. Method: We used CV-PTC (n = 6), FV-PTC (n = 6) and benign thyroid tissues (n = 6) to prepare tissue lysates...
December 2017: EuPA Open Proteomics
Luguang Chen, Peipei Sun, Qiang Hao, Wei Yin, Bing Xu, Chao Ma, Alto Stemmer, Caixia Fu, Minjie Wang, Jianping Lu
This study aimed to evaluate whether a prototype echo planar imaging sequence with integrated-shimming (iShim-EPI) can improve image quality in the thyroid gland in comparison to 3D-volume shimming echo planar imaging (3D-Shim-EPI), and to compare ADC values derived from iShim-EPI with those of 3D-Shim-EPI. Twenty-one patients with thyroid disease were enrolled and underwent axial DWIs with iShim-EPI and 3D-Shim-EPI using a 3 Tesla magnetic resonance scanner in this prospective study. Both sets of DWI images were evaluated by two independent observers who identified susceptibility and ghost artifacts and evaluated the images' capacity to detect thyroid nodules using quantitative scores...
May 25, 2018: Oncotarget
Jin-Yu Liang, Xiao-Wen Huang, Hang-Tong Hu, Yi-Hao Liu, Qian Zhou, Qing-Hua Cao, Wei Wang, Bao-Xian Liu, Yan-Ling Zheng, Xin Li, Xiao-Yan Xie, Ming-de Lu, Sui Peng, Long-Zhong Liu, Haipeng Xiao
<b>Background</b> Visual interpretation of ultrasound (US) images alone may not be sensitive enough to detect important features of potentially malignant thyroid nodules. The aim of this study was to develop a radiomics score using US imaging to predict the probability for malignancy of thyroid nodules as compared with the Thyroid Imaging, Reporting and Data System (TI-RADS) scoring criteria proposed by the American College of Radiology (ACR). <b>Methods</b> One hundred thirty-seven pathologically proven thyroid nodules from hospital #1 were enrolled as a training cohort while 95 nodules from hospital #2 served as the validation cohort...
June 13, 2018: Thyroid: Official Journal of the American Thyroid Association
Aires Martins, Alvaro Gonçalves, Teresa Almeida, Alberto Midões
Carcinoembryonic antigen (CEA) is still the most widely used tumour marker for gastrointestinal cancer. CEA was originally thought to be a specific marker for colorectal cancer, but it turned out to be a non-specific marker for further studies. CEA levels can be elevated in breast, lung and liver cancers, among others, including medullary thyroid cancer. The authors report a case of a 73-year-old woman who had a right hemicolectomy for an ascending colon adenocarcinoma and showed a persistent elevation in the CEA marker during follow-up...
June 11, 2018: BMJ Case Reports
Yongwen Zhang, Fanrong Meng, Lianqing Hong, Lanfang Chu
The study is aimed to establish a simplified and practical tool for analyzing thyroid nodules. A novel risk score model was designed, risk factors including patient history, patient characteristics, physical examination, symptoms of compression, thyroid function, ultrasonography (US) of thyroid and cervical lymph nodes were evaluated and classified into high risk factors, intermediate risk factors, and low risk factors. A total of 243 thyroid nodules in 162 patients were assessed with risk score system and Thyroid Imaging-Reporting and Data System (TI-RADS)...
June 12, 2018: Hormone and Metabolic Research, Hormon- und Stoffwechselforschung, Hormones et Métabolisme
Fatma Ela Keskin, Hande Mefkure Ozkaya, Sina Ferahman, Ozlem Haliloglu, Adem Karatas, Figen Aksoy, Pinar Kadioglu
PURPOSE: Prevalence of papillary thyroid cancer (PTC) is increased in patients with acromegaly. We aimed to determine the protein expression of BRAF, RAS, RET, insulin like growth factor 1(IGF1), Galectine 3, CD56 in patients with PTC related acromegaly and to compare the extensity of these expressions with normal PTC patients and benign thyroid nodules. METHODS: We studied 313 patients with acromegaly followed in Cerrahpasa Medical Faculty, Endocrinology and Metabolism Clinic between 1998 and 2015...
June 11, 2018: Experimental and Clinical Endocrinology & Diabetes
Aamna Hassan, Saima Riaz, Amna Asif
Thyroid incidentalomas are frequently reported on 18 F-FDG PET/CT scan. High risk of malignancy is thought to be associated with increased metabolic activity and high standardized uptake value. Likewise, thyroid nodules with focal FDG avidity have a higher potential to be malignant. However, some benign nodules such as follicular and Hurthle cell adenomas can also present with focal hypermetabolic activity. We report a case of a 59-year-old lady diagnosed with gastric carcinoma, who had a hypermetabolic thyroid nodule on FDG PET/CT scan...
June 7, 2018: Molecular Imaging and Radionuclide Therapy
Beata Bode-Lesniewska, Beatrix Cochand-Priollet, Patrizia Straccia, Guido Fadda, Massimo Bongiovanni
Thyroid nodules are common and increasingly detected due to recent advances in imaging techniques. However, clinically relevant thyroid cancer is rare and the mortality from aggressive thyroid cancer remains constant. FNAC (Fine Needle Aspiration Cytology) is a standard method for diagnosing thyroid malignancy and the discrimination of malignant nodules from goiter. As the examined nodules on thyroid FNAC are often small incidental findings, it is important to maintain a low rate of undetermined diagnoses requiring further clinical work up or surgery...
June 9, 2018: Cytopathology: Official Journal of the British Society for Clinical Cytology
D Januś, M Wójcik, A Taczanowska, P Sołtysiak, A Wędrychowicz, D Roztoczyńska, G Drabik, Ł Wyrobek, J B Starzyk
PURPOSE: To present the outcomes of ultrasound (US) follow-ups in children with autoimmune thyroid disease who did not have a thyroid nodule on admission but developed papillary thyroid carcinoma (PTC) and to characterize the parenchymal changes in the thyroid gland prior to the development of PTC. METHODS: A retrospective thyroid US scan review of 327 patients diagnosed with AIT was performed. Forty patients (40/327, 12.2%) presented nodular AIT variant with a normoechogenic background...
June 5, 2018: Journal of Endocrinological Investigation
Hye Jin Baek, Dong Wook Kim, Gi Won Shin, Young Jin Heo, Jin Wook Baek, Yoo Jin Lee, Young Jun Cho, Ha Kyoung Park, Tae Kwun Ha, Do Hun Kim, Soo Jin Jung, Ji Sun Park, Ki Jung Ahn
Background: The ultrasonographic characteristics and difference for various subtypes of papillary thyroid carcinoma (PTC) are still unclear. The aim of this study was to compare the ultrasonographic features of PTC according to its subtype in patients undergoing thyroid surgery. Methods: In total, 140 patients who underwent preoperative thyroid ultrasonography (US) and thyroid surgery between January 2016 and December 2016 were included. The ultrasonographic features and the Korean Thyroid Imaging Reporting and Data System (K-TIRADS) category of each thyroid nodule were retrospectively evaluated by a single radiologist, and differences in ultrasonographic features according to the PTC subtype were assessed...
2018: Frontiers in Endocrinology
Anupama Roy Chowdhury, Jack Kian Ch'ng, Choon Chieh Tan
Papillary thyroid cancer (PTC) can present as a thyroid cyst. In its more aggressive form, PTC may be multifocal in nature and is associated with a poorer prognosis. In patients whom PTC is diagnosed incidentally after a diagnostic lobectomy, the decision whether to offer completion thyroidectomy is sometimes challenging to make if such patients fall in the 'low-to-intermediate' risk category. We present a case of a 55-year-old lady who had a predominantly cystic left thyroid nodule with no suspicious features on ultrasound as well as 2 subcentimetre simple right-sided cysts...
2018: Case Reports in Medicine
Pablo Valderrabano, Melissa J McGettigan, Cesar Lam, Laila Khazai, Zachary J Thompson, Christine H Chung, Barbara A Centeno, Bryan McIver
BACKGROUND: The 2015 American Thyroid Association (ATA) guidelines recommend using a classification based on sonographic patterns to set the size-threshold for biopsies. Each pattern is associated with a distinct estimated rate of malignancy that, we hypothesize, should stratify the risk of malignancy of cytologically indeterminate thyroid nodules. METHODS: Ultrasound images of 463 indeterminate thyroid nodules (38% atypia/follicular lesions of undetermined significance; 62% follicular neoplasms) with histological follow-up consecutively evaluated between 10/2008 and 06/2015 at our academic cancer center were independently evaluated by 3 observers and classified into one of the five sonographic patterns proposed by the ATA...
May 31, 2018: Thyroid: Official Journal of the American Thyroid Association
Iqra Manzoor, Raham Bacha, Syed Amir Gilani
The objective of this study was to evaluate the diagnostic accuracy of sonoelastography in patients of primary and secondary health care settings. Google scholar, PubMed, Medline, Medscape, Wikipedia and NCBI were searched in October 2017 for all original studies and review articles to identify the relevant material. Two reviewers independently selected articles for evaluation of the diagnostic accuracy of sonoelastography in different diseases based on titles and abstracts retrieved by the literature search...
March 2018: Journal of Ultrasonography
Fernando Fernández-Ramírez, Luis M Hurtado-López, Mario A López, Eva Martínez-Peñafiel, Norma E Herrera-González, Luis Kameyama, Omar Sepúlveda-Robles
Thyroid cancer is the most frequent endocrine malignancy, and its incidence and prevalence are increasing worldwide. Despite its generally good prognosis, the observed mortality rates are higher in the less-developed regions. This indicates that timely diagnosis and appropriate initial management of this disease are important to achieve a positive outcome. We performed an observational study in order to describe the frequency of the BRAF 1799T>A mutation in Mexican mestizo patients with thyroid nodules, a scarcely studied ethnic group with large populations...
2018: BioMed Research International
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