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Thyroid nodule

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https://www.readbyqxmd.com/read/28635213/-risk-factors-for-central-neck-lymph-node-metastases-of-papillary-thyroid-carcinoma
#1
Y S Sun, H J Lyu, Y R Zhao, S S Zhang, Y X Bai, B Y Shi
Objective: To investigate the impact factors for central neck lymph node metastases(CLNM) of papillary thyroid carcinoma(PTC). Methods: A total of 498 patients with PTC who underwent total or hemi-thyroidectomy plus central neck lymph node dissection between January 2014 and July 2016 were included. Univariate and multivariate analyses were performed to identify clinicopathological characteristics, thyroid function parameters and US findings that associated with CLNM of PTC. A nomogram was developed to predict the probability of CLNM...
June 7, 2017: Zhonghua Er Bi Yan Hou Tou Jing Wai Ke za Zhi, Chinese Journal of Otorhinolaryngology Head and Neck Surgery
https://www.readbyqxmd.com/read/28633198/factors-related-to-the-efficacy-of-radiofrequency-ablation-for-benign-thyroid-nodules
#2
Jung Hwan Baek
No abstract text is available yet for this article.
May 17, 2017: Ultrasonography
https://www.readbyqxmd.com/read/28632145/what-really-is-an-indeterminate-fna-thyroid-nodule
#3
Angela Pezzolla, Serafina Lattarulo, Andrea Madaro, Giovanni Docimo, Emanuela Lacalendola, Francesco Prete, Rinaldo Marzaioli
BACKGROUND: Thyroid nodules are usually benign; however, 5 to 15% prove to be malignant. Fine-needle aspiration (FNA) has become the gold standard in the evaluation of thyroid nodules, especially in single nodule more than a centimeter and / or in smaller nodule with ultrasound characters of malignancy. METHODS: We evaluated retrospectively 179 patients with "undetermined" thyroid fine needle aspiration, undergoing surgery. We compared cytology and histology and we evaluated sex, age, the presence of thyroiditis and dimension of the indeterminate nodule as predictors of malignancy...
June 12, 2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/28631628/the-absence-of-cd56-expression-can-differentiate-papillary-thyroid-carcinoma-from-other-thyroid-lesions
#4
Ioana Golu, Mihaela Maria Vlad, Alis Dema, Lavinia Cristina Moleriu, Anca Tudor, Mihaela Iacob, Oana Popa, Marioara Cornianu
CONTEXT: The neural cell adhesion molecule CD56 is an antigen important for the differentiation of the follicular epithelium. Recent studies have reported low or absent expression of CD56 in papillary thyroid carcinoma (PTC) and its presence in normal thyroid tissue, benign thyroid lesions, and most follicular non-PTC tumors. AIM: We wish to estimate the value of CD56 in the differentiation of PTC (including follicular variant-PTC [FV-PTC]) from other nontumoral lesions and follicular thyroid neoplasias...
April 2017: Indian Journal of Pathology & Microbiology
https://www.readbyqxmd.com/read/28626115/reappraisal-of-cyst-fluid-only-on-thyroid-fine-needle-aspiration-cytology
#5
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
According to the Bethesda System for Reporting Thyroid Cytopathology (BSRTC), cyst fluid only (CFO) cases are classified in the non-diagnostic category. To date, no large study focusing on CFO has been conducted. To reassess the diagnostic significance of CFO, we compared CFO nodules with non-diagnostic nodules excluding CFO (ND-other). We reviewed the conventional thyroid smears of 715 CFO and 766 ND-other nodules. We compared the timing of and findings at re-aspiration, the histology of resected specimens, and the proportion of malignant nodules between the two groups...
June 13, 2017: Endocrine Journal
https://www.readbyqxmd.com/read/28625707/-algorithms-based-on-medico-administrative-data-in-the-field-of-endocrine-nutritional-and-metabolic-diseases-especially-diabetes
#6
S Fosse-Edorh, A Rigou, S Morin, L Fezeu, L Mandereau-Bruno, A Fagot-Campagna
BACKGROUND: Medico-administrative databases represent a very interesting source of information in the field of endocrine, nutritional and metabolic diseases. The objective of this article is to describe the early works of the Redsiam working group in this field. METHODS: Algorithms developed in France in the field of diabetes, the treatment of dyslipidemia, precocious puberty, and bariatric surgery based on the National Inter-schema Information System on Health Insurance (SNIIRAM) data were identified and described...
June 15, 2017: Revue D'épidémiologie et de Santé Publique
https://www.readbyqxmd.com/read/28624796/comparison-of-differentiated-thyroid-carcinoma-recurrence-and-its-clinical-features-in-children-of-different-ages
#7
Bin Ye, Jun Shi, Chenling Shen, Longhao Wang, Haixia Hu, Yan Ma, Quan Wang, Jingrong Lu, Guangjun Yu, Mingliang Xiang
 The prevalence of differentiated thyroid carcinoma (DTC) in children is increasing. However, the clinical features and recurrence of DTC in children in different age groups, especially those less than 14 years old, are not well studied. We retrospectively investigated 73 children diagnosed with DTC in our hospital between January 1998 and July 2014. Data were reviewed for different age groups based on the age at initial diagnosis: 5-9, 10-14, or 15-19 years. The mean age of the recurrence group (10.6±4.1 years) was lower than that of the non-recurrence group (12...
May 26, 2017: Oncotarget
https://www.readbyqxmd.com/read/28621914/distinguishing-parathyroid-and-thyroid-lesions-on-ultrasound-guided-fine-needle-aspiration-a-correlation-of-clinical-data-ancillary-studies-and-molecular-analysis
#8
Margaret Cho, Thaira Oweity, Tamar C Brandler, Karen Fried, Pascale Levine
BACKGROUND: Differentiating parathyroid and thyroid lesions can be challenging because of considerable morphologic overlap and anatomic proximity. Therefore, the authors sought to identify characteristic morphologic patterns and useful adjunct tests to distinguish these 2 entities. METHODS: A search was conducted in the study institution database for clinically indeterminate thyroid nodules from 2000 through 2016 with an emphasis on confirmed parathyroid nodules...
June 16, 2017: Cancer
https://www.readbyqxmd.com/read/28618022/utility-of-a-formatted-pathologic-reporting-system-in-thyroid-core-needle-biopsy-a-validation-study-of-1998-consecutive-cases
#9
Ji-Young Choe, Yoonjin Kwak, Mimi Kim, Yul Ri Chung, Hyun Jeong Kim, Yeo Koon Kim, So Yeon Park
OBJECTIVE: Thyroid core needle biopsy (CNB) is increasingly being used as a tool for evaluating thyroid nodules; thus, standardization of its diagnostic terminology is called for. We aimed to analyze the pathologic reporting system of thyroid CNB based on the recently proposed protocol by the Korean Endocrine Pathology Thyroid Core Needle Biopsy Study Group and evaluate its usefulness. DESIGN/METHODS: 1998 consecutive cases of thyroid CNBs were reviewed and divided into 6 categories according to the protocol...
June 15, 2017: Clinical Endocrinology
https://www.readbyqxmd.com/read/28616852/ultrasonographic-prediction-of-highly-aggressive-telomerase-reverse-transcriptase-tert-promoter-mutated-papillary-thyroid-cancer
#10
Tae Hyuk Kim, Chang-Seok Ki, Soo Yeon Hahn, Young Lyun Oh, Hye Won Jang, Sun Wook Kim, Jae Hoon Chung, Jung Hee Shin
PURPOSE: Telomerase reverse transcriptase promoter mutations are found in highly aggressive thyroid malignancies. Our aim was to define the ultrasonographic features of telomerase reverse transcriptase promoter-mutated papillary thyroid cancer and to evaluate their predictive performances. METHODS: Ultrasonographic findings were reviewed for 185 patients with surgically confirmed papillary thyroid cancer between 1994 and 2004. Genomic DNA to identify telomerase reverse transcriptase promoter mutations was extracted from archived surgical specimens...
June 14, 2017: Endocrine
https://www.readbyqxmd.com/read/28616727/preliminary-study-of-diffusion-kurtosis-imaging-in-thyroid-nodules-and-its-histopathologic-correlation
#11
Ruo-Yang Shi, Qiu-Ying Yao, Qin-Yi Zhou, Qing Lu, Shi-Teng Suo, Jun Chen, Wen-Jie Zheng, Yong-Ming Dai, Lian-Ming Wu, Jian-Rong Xu
OBJECTIVES: To evaluate the utility of diffusion kurtosis imaging (DKI) of patients with thyroid nodules and to assess the probable correlation with histopathological factors. METHODS: The study included 58 consecutive patients with thyroid nodules who underwent magnetic resonance imaging (MRI) examination, including DKI and diffusion-weighted imaging (DWI). Histopathological analysis of paraffin sections included cell density and immunohistochemical analysis of Ki-67 and vascular endothelial growth factor (VEGF)...
June 14, 2017: European Radiology
https://www.readbyqxmd.com/read/28614008/the-role-of-electronic-feedback-loops-in-the-continuous-quality-improvement-of-thyroid-nodule-and-thyroid-cancer-care
#12
Mark L Urken, Gregory Randolph, Lisa Orloff, Bruce M Wenig, Rosalie Machado, Marcela Osorio, Martha Griffin, R Michael Tuttle
No abstract text is available yet for this article.
June 14, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/28612287/methylation-markers-differentiate-thyroid-cancer-from-benign-nodules
#13
J K Stephen, K M Chen, J Merritt, D Chitale, G Divine, M J Worsham
PURPOSE: The incidence of thyroid cancer (TC) is increasing. Cytology by itself cannot distinguish TC from some benign nodules especially in certain subtypes of TC. Our immediate goal is to identify DNA methylation markers for early detection of TC and to molecularly differentiate TC subtypes from benign nodules. METHODS: Promoter methylation status of 21 candidate genes was examined on formalin-fixed paraffin-embedded tissue (FFPE) utilizing quantitative methylation-specific polymerase chain reaction (QMSP) in a retrospective cohort of 329 patients (56% white, 29% African American, 61% female) comprising 71 normal thyroid, 83 benign nodules [follicular adenomas (FA)], 90 follicular TC (FTC) and 85 papillary TC (PTC)...
June 13, 2017: Journal of Endocrinological Investigation
https://www.readbyqxmd.com/read/28609825/the-use-of-the-bethesda-system-for-reporting-thyroid-cytopathology-in-korea-a-nationwide-multicenter-survey-by-the-korean-society-of-endocrine-pathologists
#14
Mi Mi Kim, Hyo Jin Park, Hye Sook Min, Hyeong Ju Kwon, Chan Kwon Jung, Seoung Wan Chae, Hyun Ju Yoo, Yoo Duk Choi, Mi Ja Lee, Jeong Ja Kwak, Dong Eun Song, Dong Hoon Kim, Hye Kyung Lee, Ji Yeon Kim, Sook Hee Hong, Jang Sihn Sohn, Hyun Seung Lee, So Yeon Park, Soon Won Hong, Mi Kyung Shin
Background: The Bethesda System for Reporting Thyroid Cytopathology (TBSRTC) has standardized the reporting of thyroid cytology specimens. The objective of the current study was to evaluate the nationwide usage of TBSRTC and assess the malignancy rates in each category of TBSRTC in Korea. Materials and Methods: Questionnaire surveys were used for data collection on the fine needle aspiration (FNA) of thyroid nodules at 74 institutes in 2012. The incidences and follow-up malignancy rates of each category diagnosed from January to December, 2011, in each institute were also collected and analyzed...
June 14, 2017: Journal of Pathology and Translational Medicine
https://www.readbyqxmd.com/read/28609009/triage-of-the-indeterminate-thyroid-aspirate-what-are-the-options-for-the-practicing-cytopathologist
#15
Ayse M Onenerk, Marc P Pusztaszeri, Sule Canberk, William C Faquin
Fine-needle aspiration (FNA) plays a key role in the early evaluation of patients with thyroid nodules; however, from 15% to 30% of FNA specimens are cytologically indeterminate. Molecular testing has proven useful when applied to indeterminate thyroid FNAs, and its use has been endorsed in the American Thyroid Association guidelines. In addition to the noncommercial ("in-house") application of v-Raf murine sarcoma viral oncogene homolog B1 (BRAF), rat sarcoma (RAS), rearranged in transformation/papillary thyroid carcinoma (RET/PTC), and peroxisome proliferator-activated receptor γ/paired box gene 8 (PPARγ/PAX8) testing, there are currently 3 commercially available molecular panels that vary in their relative reported performances, strengths, and limitations...
June 2017: Cancer
https://www.readbyqxmd.com/read/28608502/systematic-differences-between-ultrasound-and-pathological-evaluation-of-thyroid-nodules-a-method-comparison-study
#16
Carolyn R Chew, Tracey Lam, Steven T F Chan, Laura Chin-Lenn
BACKGROUND: The size of thyroid nodules as measured by ultrasound (ultrasound size, USS) is routinely used in clinical decision-making. Reports of discrepancy between USS and pathological size (PS) evaluation have not analysed their systematic differences. The objective of this study was to uncover the lack of agreement (bias) between USS and PS measurements. METHODS: A retrospective study was performed on 121 patients who had a total or hemi-thyroidectomy for a solitary nodule...
June 13, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28607535/gender-disparity-in-the-relationship-between-prevalence-of-thyroid-nodules-and-metabolic-syndrome-components-the-shdc-cdpc-community-based-study
#17
Xiaoying Ding, Ying Xu, Yufan Wang, Xiaohua Li, Chunhua Lu, Jing Su, Yuting Chen, Yuhang Ma, Yanhua Yin, Yong Wu, Yaqiong Jin, Lihua Yu, Junyi Jiang, Naisi Zhao, Qingwu Yan, Andrew S Greenberg, Haiyan Sun, Mingyu Gu, Li Zhao, Yunhong Huang, Yijie Wu, Chunxian Qian, Yongde Peng
The study is aimed to investigate the pathogenesis underlying the increased prevalence of thyroid nodule (TN) in different levels of metabolic syndrome (MetS) components and analyze the relationships between TN and MetS components. A total of 6,798 subjects, including 2201 patients with TN, were enrolled in this study. Anthropometric, biochemical, thyroid ultrasonographic, and other metabolic parameters were all measured. There was obviously sexual difference in the prevalence of TN (males 26.0%, females 38...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28605944/a-comparison-of-laser-with-radiofrequency-ablation-for-the-treatment-of-benign-thyroid-nodules-a-propensity-score-matching-analysis
#18
Claudio Maurizio Pacella, Giovanni Mauri, Roberto Cesareo, Valerio Paqualini, Roberto Cianni, Pierpaolo De Feo, Giovanni Gambelunghe, Bruno Raggiunti, Doris Tina, Maurilio Deandrea, Pier Paolo Limone, Alberto Mormile, Massimo Giusti, Silvia Oddo, Gaetano Achille, Enrico Di Stasio, Irene Misischi, Enrico Papini
PURPOSE: To compare technique efficacy and safety of laser ablation (LA) and radiofrequency ablation (RFA) in treatment of benign thyroid nodules. MATERIALS AND METHODS: Institutional review board approval was obtained, and patients' consent was waived. 601 nodules were treated from May 2009 to December 2014 at eight centres, 449 (309 females, age 57 ± 14 years) with LA and 152 (107 females, age 57 ± 14 years) with RFA. A matched cohort composed of 138 patients from each group was selected after adjustment with propensity score matching...
June 12, 2017: International Journal of Hyperthermia
https://www.readbyqxmd.com/read/28605303/diagnostic-value-of-circulating-microrna-95-and-190-in-the-differential-diagnosis-of-thyroid-nodules-a-validation-study-in-1000-consecutive-patients
#19
Tania Pilli, Silvia Cantara, Carlotta Marzocchi, Sandro Cardinale, Chiara Santini, Gabriele Cevenini, Furio Pacini
BACKGROUND: It has recently been demonstrated that the combination of miRNA-190 and -95 (expressed as probability of malignant risk: pmiRNA) in the serum of Caucasian patients with thyroid nodular disease allows the identification of nodules at high risk of malignancy with great accuracy. The present study aimed to validate these results in a larger cohort of patients. MATERIALS AND METHODS: This study prospectively analyzed 1000 patients. Cytological diagnosis was available in 982/1000 (98...
June 12, 2017: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/28603936/laryngeal-chondrosarcoma-mimicking-medullary-thyroid-carcinoma-on-fine-needle-aspiration-cytology-a-case-report-of-a-diagnostic-pitfall
#20
Shifteh Vahidi, Khalid Amin, Jimmie Stewart
Chondrosarcoma (CS) of larynx is a rare laryngeal tumor accounting about 1% of laryngeal malignancies. When CS arises from thyroid cartilage, it may clinically present as a thyroid nodule. Here we report a rare case of CS of thyroid cartilage misinterpreted as medullary thyroid carcinoma. The main aim of this case report is to emphasize the important role of accurate clinical history, appropriate physical examination, and proper localization of the tumor and clear definitive imaging in conjunction with interpretation of cytologic smears...
June 11, 2017: Diagnostic Cytopathology
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