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https://www.readbyqxmd.com/read/28079145/galectin-3-as-a-marker-of-interstitial-atrial-remodelling-involved-in-atrial-fibrillation
#1
Diana Hernández-Romero, Juan Antonio Vílchez, Álvaro Lahoz, Ana I Romero-Aniorte, Eva Jover, Arcadio García-Alberola, Rubén Jara-Rubio, Carlos M Martínez, Mariano Valdés, Francisco Marín
Remodelling in the atria could appear as a result of hypertension, diabetes or ischaemic heart disease. Galectin-3 (Gal-3) is a mediator of profibrotic pathways and a potential biomarker of cardiac remodelling. We prospectively recruited consecutive patients undergoing elective cardiac surgery. Preoperative Gal-3 levels were determined from serum samples, and the presence of fibrosis was assessed from atrial appendage tissue samples obtained during cardiac surgery. We included 100 patients with aortic valve or ischaemic heart diseases and 15 controls with permanent AF...
January 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28069837/high-sensitive-cardiac-troponin-t-as-a-novel-predictor-for-recurrence-of-atrial-fibrillation-after-radiofrequency-catheter-ablation
#2
Koki Nakanishi, Shota Fukuda, Hajime Yamashita, Toshifumi Hasegawa, Michihiko Kosaka, Naoya Shirai, Kenei Shimada, Junichi Yoshikawa, Atsushi Tanaka
AIMS: We aimed to determine whether elevated serum high-sensitive cardiac troponin T (hs-TnT) levels predict atrial fibrillation (AF) recurrence after pulmonary vein isolation (PVI). METHODS AND RESULTS: We included 125 consecutive patients with AF (paroxysmal, n = 79; persistent, n = 46) who underwent first-time PVI. Serum hs-TnT, high-sensitive C-reactive protein (hs-CRP), atrial natriuretic peptide, and plasma B-type natriuretic peptide levels were measured in venous samples collected before PVI...
January 8, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/28043673/renal-replacement-therapy-in-patients-with-acute-myocardial-infarction-rate-of-use-clinical-predictors-and-relationship-with-in-hospital-mortality
#3
Giancarlo Marenzi, Nicola Cosentino, Andrea Marinetti, Antonio M Leone, Valentina Milazzo, Mara Rubino, Monica De Metrio, Angelo Cabiati, Jeness Campodonico, Marco Moltrasio, Silvio Bertoli, Milena Cecere, Susanna Mosca, Ivana Marana, Marco Grazi, Gianfranco Lauri, Alice Bonomi, Fabrizio Veglia, Antonio L Bartorelli
OBJECTIVES: We evaluated the rate of use, clinical predictors, and in-hospital outcome of renal replacement therapy (RRT) in acute myocardial infarction (AMI) patients. METHODS: All consecutive AMI patients admitted to the Coronary Care Unit between January 1st, 2005 and December 31st, 2015 were identified through a search of our prospectively collected clinical database. Patients were grouped according to whether they required RRT or not. RESULTS: Two-thousand-eight-hundred-thirty-nine AMI patients were included...
December 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28043667/a-sirtuin-1-mmp2-prognostic-index-for-myocardial-infarction-in-patients-with-advanced-coronary-artery-disease
#4
Ilias P Doulamis, Aspasia I Tzani, Panagiotis S Konstantopoulos, George Samanidis, Georgios Georgiopoulos, Konstantinos P Toutouzas, Despina N Perrea, Konstantinos G Perreas
BACKGROUND: Sirtuin 1 (SIRT1) appears to play a protective role against endothelial dysfunction and oxidative stress. Instead, matrix metalloproteinase 2 (MMP2) is involved in acute coronary events, by promoting tissue remodeling. This study sought to determine the clinical value of a prognostic index arising from the combination of these two biomarkers for myocardial infarction (MI) in patients with advanced coronary artery disease. METHODS: Eighty-one patients with advanced coronary artery disease planned for open heart surgery were prospectively enrolled...
December 23, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/28040325/why-are-south-asians-seemingly-protected-against-the-development-of-atrial-fibrillation-a-review-of-current-evidence
#5
REVIEW
James O'Neill, Muzahir H Tayebjee
Atrial fibrillation (AF) is the commonest sustained cardiac arrhythmia and is strongly associated with conditions such as valvular heart disease, coronary artery disease and particularly hypertension and diabetes mellitus. The South Asian ethnic group have high rates of these conditions and so would be expected to be at significant risk of AF. However, observational studies have consistently shown that South Asians have a lower prevalence of AF compared with Caucasians. This article summarizes current evidence surrounding the development of AF and its relationship to ethnicity, offers potential reasons for this disparity and identifies future areas of research...
November 25, 2016: Trends in Cardiovascular Medicine
https://www.readbyqxmd.com/read/28029216/safety-and-efficacy-of-non-vitamin-k-antagonist-oral-anticoagulants-versus-warfarin-in-diabetic-patients-with-atrial-fibrillation-a-study-level-meta-analysis-of-phase-iii-randomized-trials
#6
REVIEW
Giuseppe Patti, Giuseppe Di Gioia, Ilaria Cavallari, Antonio Nenna
BACKGROUND: In patients with atrial fibrillation (AF) the safety and efficacy of non-vitamin K antagonist oral anticoagulants (NOACs) vs warfarin according to diabetes mellitus (DM) status is not completely characterized; we performed a meta-analysis to clarify whether in these patients the strategy of oral anticoagulation should be tailored on diabetes status METHODS: In this study-level meta-analysis we included four randomized phase III trials comparing NOACs and warfarin in patients with non-valvular AF; a total of 18,134 patients with DM and 40,454 without DM were overall considered...
December 28, 2016: Diabetes/metabolism Research and Reviews
https://www.readbyqxmd.com/read/28028458/risk-of-lung-cancer-in-patients-with-gastro-esophageal-reflux-disease-a-population-based-cohort-study
#7
Chi-Kuei Hsu, Chih-Cheng Lai, Kun Wang, Likwang Chen
This large-scale, controlled cohort study estimated the risks of lung cancer in patients with gastro-esophageal reflux disease (GERD) in Taiwan. We conducted this population-based study using data from the National Health Insurance Research Database of Taiwan during the period from 1997 to 2010. Patients with GERD were diagnosed using endoscopy, and controls were matched to patients with GERD at a ratio of 1:4. We identified 15,412 patients with GERD and 60,957 controls. Compared with the controls, the patients with GERD had higher rates of osteoporosis, diabetes mellitus, asthma, chronic obstructive pulmonary disease, pneumonia, bronchiectasis, depression, anxiety, hypertension, dyslipidemia, chronic liver disease, congestive heart failure, atrial fibrillation, stroke, chronic kidney disease, and coronary artery disease (all P < ...
2016: PeerJ
https://www.readbyqxmd.com/read/28028073/thiazolidinediones-are-associated-with-a-decreased-risk-of-atrial-fibrillation-compared-with-other-antidiabetic-treatment-a-nationwide-cohort-study
#8
Jannik Langtved Pallisgaard, Tommi Bo Lindhardt, Laila Staerk, Jonas Bjerring Olesen, Christian Torp-Pedersen, Morten Lock Hansen, Gunnar Hilmar Gislason
AIM: The aim of this study was to investigate the association between thiazolidinediones (TZDs) vs. other antidiabetic drugs and risk of atrial fibrillation (AF) in diabetic patients. METHOD AND RESULTS: Diabetes mellitus (diabetes) increases the risk of AF by approximately 34%. TZD is an insulin sensitizer that also has anti-inflammatory effects, which might decrease the risk of AF compared with other antidiabetic drugs. We used data from the Danish nationwide registries to study 108 624 patients with diabetes and without prior AF who were treated with metformin or sulfonylurea as first-line drugs...
November 8, 2016: European Heart Journal. Cardiovascular Pharmacotherapy
https://www.readbyqxmd.com/read/28005263/does-early-onset-cataract-increase-the-risk-of-ischemic-stroke-a-nationwide-retrospective-cohort-study
#9
Chih-Yang Huang, Tung-Sheng Chen, Cheng-Li Lin, Wei-Syun Hu
This study was attempted to address the association between early onset cataract (EOC) and ischemic stroke. Using the Longitudinal Health Insurance Database 2000, we established an EOC cohort and a comparison cohort by using 4-fold propensity score matching according to age, gender and comorbidities to detect the incidence of ischemic stroke. A Cox model was used to express the risk of ischemic stroke for the EOC patients compared with the comparison cohort. After adjusting for age, gender and comorbidities of hypertension, diabetes mellitus, hyperlipidemia, coronary artery disease, asthma, chronic obstructive pulmonary disease, chronic kidney disease, heart failure, obesity, and atrial fibrillation, the EOC patients had a 1...
December 22, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27978516/prognostic-significance-of-dementia-in-older-adults-with-solid-tumors
#10
Supakanya Wongrakpanich, Amy Hurst, Jean Bustamante, Nellowe Candelario, Sylvia Biso, Wikrom Chaiwatcharayut, Claudia Dourado, Andrew Rosenzweig
BACKGROUND: The public health burden of cancer and dementia in the geriatric population is well documented. There is limited data on how dementia predicts mortality among geriatric patients with solid tumors. The objective of this study is to determine the prognostic significance of dementia on survival in patients with solid tumors. METHODS: We performed a 5-year retrospective study on elderly subjects aged ≥60 years with and without dementia that were diagnosed with solid tumors...
December 16, 2016: Dementia and Geriatric Cognitive Disorders
https://www.readbyqxmd.com/read/27956001/relation-of-functional-status-to-risk-of-development-of-atrial-fibrillation
#11
Satish Ramkumar, Hong Yang, Ying Wang, Mark Nolan, Kazuaki Negishi, Prashanthan Sanders, Thomas Hugh Marwick
Identifying patients at risk is now important as there are demonstrable ways to alter disease progression which could potentially prevent atrial fibrillation (AF) and its complications. We sought whether impaired functional capacity was associated with risk of AF, independent of myocardial dysfunction. In this community-based study, asymptomatic participants aged ≥65 years were recruited if they had ≥1 risk factor (e.g., hypertension, diabetes mellitus, and obesity). Participants underwent baseline echocardiography (including measurement of myocardial mechanics) and six-minute walk test...
November 16, 2016: American Journal of Cardiology
https://www.readbyqxmd.com/read/27940934/adverse-outcomes-in-patients-with-atrial-fibrillation-and-peripheral-arterial-disease-a-report-from-the-eurobservational-research-programme-pilot-survey-on-atrial-fibrillation
#12
Marco Proietti, Valeria Raparelli, Cécile Laroche, Georghe-Andrei Dan, Marianna Janion, Raluca Popescu, Gianfranco Sinagra, Johan Vijgen, Giuseppe Boriani, Aldo P Maggioni, Luigi Tavazzi, Gregory Y H Lip
AIMS: Peripheral arterial disease (PAD) is highly prevalent in general population. Data on the prevalence of symptomatic PAD in patients with atrial fibrillation (AF) are limited, and the impact of PAD on adverse outcomes in AF patients is controversial. Our aims were: (i) to define the prevalence of symptomatic PAD in European AF patients and describe its associated clinical risk factors and (ii) to establish the relationship of PAD to adverse events in AF, especially all-cause death...
December 8, 2016: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/27939441/cardiovascular-risk-factors-nonvalvular-atrial-fibrillation-and-retinal-vein-occlusion
#13
M Lisa Gracia, A Córdoba Alonso, J L Hernández Hernández, R Pérez Montes, J J Napal Lecumberri
OBJECTIVES: To analyse the importance of cardiovascular risk factors, ultrasound findings in the supra-aortic trunk and the presence of anticoagulated nonvalvular atrial fibrillation (NVAF) in patients with retinal vein occlusion (RVO) and in a control group. PATIENTS AND METHODS: A cross-sectional study was conducted of all patients with RVO consecutively referred to the office of internal medicine, comparing them with a control group. We analysed clinical, electrocardiographic and ultrasound variables...
December 7, 2016: Revista Clínica Española
https://www.readbyqxmd.com/read/27939141/clinical-profile-and-changes-of-serum-lipid-levels-in-epileptic-patients-after-cerebral-infarction
#14
Ken Ikeda, Masahiro Sawada, Harumi Morioka, Maya Kyuzen, Junya Ebina, Junpei Nagasawa, Masaru Yanagihashi, Ken Miura, Yuichi Ishikawa, Takehisa Hirayama, Takanori Takazawa, Osamu Kano, Kiyokazu Kawabe, Yasuo Iwasaki
BACKGROUND: Antiepileptic drugs (AEDs) may increase development of dyslipidemia and cerebrovascular disease (CVD). We examined the clinical profile and changes of serum lipid levels after AED monotherapy in patients with poststroke epilepsy (PSE) after cerebral infarction (CI). SUBJECTS AND METHODS: Medical records were reviewed in consecutive 2144 CI patients. Monotherapy of valproate, carbamazepine (CBZ), phenytoin (PHT), zonisamide, levetiracetam, or lamotrigine was performed in PSE patients...
December 8, 2016: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/27933105/prevalence-of-atrial-fibrillation-in-the-malaysian-communities
#15
Chiao Wen Lim, Sazzli Kasim, Johan Rizwal Ismail, Nicholas Yul Chye Chua, Rizmy Najme Khir, Hafisyatul Aiza Zainal Abidin, Effarezan Abdul Rahman, Mohd Kamal Mohd Arshad, Zubin Ibrahim Othman, Khalid Yusoff
BACKGROUND AND AIM: Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia encountered in clinical practice. The REDISCOVER (Responding to Increasing Cardiovascular disease prevalence) study is an observational longitudinal community-based study that tracks changing lifestyles, risk factors and chronic disease in urban and rural areas of Malaysia. In this study, we aim to study the prevalence of AF and its associated risk factors. METHODS: The study was conducted between 2007 and 2014...
2016: Heart Asia
https://www.readbyqxmd.com/read/27924216/atrial-fibrillation-management-in-older-heart-failure-patients-a-complex-clinical-problem
#16
REVIEW
Giovanni Pulignano, Donatella Del Sindaco, Maria Denitza Tinti, Stefano Tolone, Giovanni Minardi, Antonio Lax, Massimo Uguccioni
BACKGROUND: Atrial fibrillation (AF) and heart failure (HF), two problems of growing prevalence as a consequence of the ageing population, are associated with high morbidity, mortality, and healthcare costs. AF and HF also share common risk factors and pathophysiologic processes such as hypertension, diabetes mellitus, ischemic heart disease, and valvular heart disease often occur together. Although elderly patients with both HF and AF are affected by worse symptoms and poorer prognosis, there is a paucity of data on appropriate management of these patients...
January 2016: Heart International
https://www.readbyqxmd.com/read/27919874/diltiazem-versus-metoprolol-for-rate-control-in-atrial-fibrillation-with-rapid-ventricular-response-in-the-emergency-department
#17
Michelle C Hines, Brent N Reed, Vijay Ivaturi, Laura J Bontempo, Michael C Bond, Bryan D Hayes
PURPOSE: The impact of patient-specific factors on the choice of β-blocker versus calcium channel blocker therapy for rate control in emergency department (ED) patients treated for atrial fibrillation (AF) was investigated. METHODS: A retrospective cohort study was conducted to evaluate the influence of demographics, prior medication use, hemodynamic and clinical characteristics, and other variables on selection of first-line therapy for AF among patients admitted to the ED of an academic medical center over a 22-month period (October 2012-July 2014) who received i...
December 15, 2016: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/27914836/perioperative-retinal-artery-occlusion-risk-factors-in-cardiac-surgery-from-the-united-states-national-inpatient-sample-1998-2013
#18
Tyler Calway, Daniel S Rubin, Heather E Moss, Charlotte E Joslin, Katharina Beckmann, Steven Roth
PURPOSE: To study the incidence and risk factors for retinal artery occlusion (RAO) in cardiac surgery. DESIGN: Retrospective study using the National Inpatient Sample (NIS). METHODS: The NIS was searched for cardiac surgery. Retinal artery occlusion was identified by International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. Postulated risk factors based on literature review were included in multivariate logistic models...
November 30, 2016: Ophthalmology
https://www.readbyqxmd.com/read/27913059/cha2ds2-vasc-scores-and-major-bleeding-in-patients-with-nonvalvular-atrial-fibrillation-who-are-receiving-rivaroxaban
#19
W Frank Peacock, Sally Tamayo, Manesh Patel, Nicholas Sicignano, Kathleen P Hopf, Zhong Yuan
STUDY OBJECTIVE: Assessing stroke risk associated with nonvalvular atrial fibrillation depends on the evaluation of patient characteristics and clinical features. Clinicians must determine that the net clinical benefit from anticoagulation therapy outweighs its risk, namely, bleeding. Risk assessment for stroke is commonly performed by calculating a CHA2DS2-VASc (congestive heart failure/left ventricular dysfunction, hypertension, ≥75 years, diabetes mellitus, previous stroke or transient ischemic attack or thromboembolism, vascular disease, aged 65 to 74 years, sex female) score...
November 29, 2016: Annals of Emergency Medicine
https://www.readbyqxmd.com/read/27909151/cerebrovascular-disease-associated-risk-factors-and-antithrombotic-therapy-in-a-population-screening-cohort-insights-from-the-belgian-heart-rhythm-week-programme
#20
Marco Proietti, Georges H Mairesse, Peter Goethals, Christophe Scavee, Johan Vijgen, Ivan Blankoff, Yves Vandekerckhove, Gregory Yh Lip
BACKGROUND: Cerebrovascular disease confers a major healthcare burden worldwide and is a major cause of death and disability. Several well-established risk factors, such as atrial fibrillation (AF), are associated with cerebrovascular disease and antithrombotic therapy reduces risk. DESIGN: This study was a subgroup analysis from the Belgian Heart Rhythm Week, a nationwide AF awareness programme. METHODS: We studied subjects screened between 2012 and 2014 with available data on clinical risk factors and antithrombotic treatment...
December 1, 2016: European Journal of Preventive Cardiology
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