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hypertension resistent

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https://www.readbyqxmd.com/read/28650932/incremental-value-of-right-atrial-strain-for-early-diagnosis-of-hemodynamic-deterioration-in-pulmonary-hypertension-a-new-noninvasive-tool-for-a-more-comprehensive-diagnostic-paradigma
#1
Cristina Piccinino, Ailia Giubertoni, Jacopo Zanaboni, Miriam Gravellone, Daniele Sola, Roberta Rosso, Lorena Ferrarotti, Paolo Nicola Marino
AIMS: Increased right atrial size is related to adverse prognosis in pulmonary hypertension. The potential incremental value of right atrial function assessment is still unclear. We tested the relationship between right atrial two-dimensional speckle-tracking echocardiography impairment and hemodynamic, functional and clinical deterioration in patients with pulmonary hypertension. METHODS: We prospectively evaluated 36 patients (27 female, 9 male; mean age 68 ± 13 years) with suspected pulmonary hypertension undergoing right heart catheterization and 16 matched controls...
June 24, 2017: Journal of Cardiovascular Medicine
https://www.readbyqxmd.com/read/28650912/the-effect-of-vasodilator-%C3%AE-blockers-on-renal-function-in-hypertensive-patients
#2
Lawrence H Kwon, Karan Wats, Clive Rosendorff
BACKGROUND: Not only is there a limited number of studies on the effects of vasodilator β-blocker (VBB) therapy on kidney function - specifically, glomerular filtration rate (GFR), serum creatinine (sCr) and proteinuria - but of those that have been reported, the results are mixed. This meta-analysis seeks to assess the efficacy of VBBs on selected renal parameters in hypertensive patients. METHODS: We conducted a meta-analysis of any prospective trial that provided both baseline and follow-up of at least 4 weeks of VBB therapy - carvedilol, labetalol, dilevalol, nebivolol and celiprolol in patients with hypertension...
June 24, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/28648322/induction-of-type-2-diabetes-mellitus-with-antihypertensive-therapy-is-there-any-role-of-alpha-adducin-ace-and-irs-1-gene
#3
REVIEW
Sumeet Gupta, Vikas Jhawat
Hypertension and diabetes are related disorders that share common pathophysiological pathways and occur together. Although hypertension itself is a risk factor for developing diabetes, prolonged use of first-line antihypertensive therapy has also been reported to induce diabetes. Genetic polymorphism of genes affecting salt sensitivity and insulin resistance can have a role in antihypertensive therapy-induced diabetes. Polymorphism of the alpha adducin gene, angiotensin-converting enzyme gene, and insulin receptor substrate 1 gene has been found to be associated with new incident diabetes in hypertensive patients via salt sensitivity and insulin resistance...
May 2017: Value in Health Regional Issues
https://www.readbyqxmd.com/read/28648026/-serum-uric-acid-is-associated-with-disease-severity-and-an-important-predictor-for-clinical-outcome-in-patients-with-pulmonary-hypertension
#4
D L Luo, C J Zhang, Y G Huang, T Huang, H Z Li
Objective: The growing body of literature showed a link between uric acid and pulmonary hypertension (PH), but the impact of hyperuremia on outcome of patients with PH has not been well defined. Therefore, the present study was performed to analyze the impact of uric acid on outcome of PH patients. Methods: One hundred seventy-three PH patients (112 females, mean age 38 years old), who were hospitalized in our department between January 2010 and December 2015, were included in our study, the PH diagnosis was made based on right heart catheterization examination result (mean pulmonary artery pressure≥25 mmHg(1 mmHg=0...
June 24, 2017: Zhonghua Xin Xue Guan Bing za Zhi
https://www.readbyqxmd.com/read/28646699/insulin-and-the-polycystic-ovary-syndrome
#5
REVIEW
Djuro Macut, Jelica Bjekić-Macut, Dario Rahelić, Mirjana Doknić
Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy among women during reproductive age. PCOS is characterised by hyperandrogenaemia, hyperinsulinaemia, and deranged adipokines secretion from the adipose tissue. In addition to the reduced insulin sensitivity, PCOS women exhibit β-cell dysfunction as well. Low birth weight and foetal exposure to androgens may contribute to the development of the PCOS phenotype during life. Further metabolic complications lead to dyslipidaemia, worsening obesity and glucose tolerance, high prevalence of metabolic syndrome, and greater susceptibility to diabetes...
June 12, 2017: Diabetes Research and Clinical Practice
https://www.readbyqxmd.com/read/28644975/a-neural-blood-pressure-marker-for-bioelectronic-medicines-for-treatment-of-hypertension
#6
Cristian Sevcencu, Thomas N Nielsen, Johannes J Struijk
A novel therapeutic approach for treating resistant hypertension could be the use of bioelectronic medicines to achieve blood pressure (BP) control in implanted patients by closed-loop stimulation of the left vagus nerve (LVN). However, such a technology would require an implantable BP marker, which is not available yet. As it is known that the LVN conducts afferent BP-related signals, this study aimed to investigate if such signals could be recorded with implantable means and used to derive BP markers. The present experiments were performed in anesthetized pigs subjected to a transient or stable BP increase induced by adrenaline administration...
June 17, 2017: Biosensors & Bioelectronics
https://www.readbyqxmd.com/read/28642065/severe-and-resistant-hypertension-in-an-older-woman-with-claudication
#7
Puneet Gupta, Robert Hagberg, Electra Kaloudis, Anika Lucas, Parth Shah, William B White
Coarctation of the aorta is an uncommon cause of treatment-resistant hypertension in adults. It is typically detected and treated in infancy or childhood with surgical or endovascular procedures. Most cases of recurrence of coarctation after repair occur in childhood or early adulthood; recurrence in older persons (>70 years) has rarely been reported. A 73-year-old woman was referred to us for the management of treatment-resistant hypertension accompanied by symptoms of claudication and headaches, which had resulted in multiple emergency room visits...
June 1, 2017: Journal of the American Society of Hypertension: JASH
https://www.readbyqxmd.com/read/28642014/acute-hemodynamic-effects-of-intravenous-adenosine-in-patients-with-associated-pulmonary-arterial-hypertension-comparison-with-intravenous-epoprostenol
#8
Rosario Rossi, Francesca Coppi, Fabio Sgura, Daniel Monopoli, Giuseppe Boriani
Exogenous intravenous (IV) adenosine and epoprostenol are effective vasodilator agents, causing a substantial reduction in pulmonary vascular resistance in patients affected by idiopathic pulmonary arteriolar hypertension (PAH). Their action, in patients with PAH associated with other pathological conditions, is not well defined. In the present paper the authors retrospectively analyzed the acute hemodynamic effects of intravenous adenosine and epoprostenol in 30 consecutive patients (mean age: 58 ± 15 years; 21 females, and 9 males) affected by PAH associated with other pathological conditions, as determined by changes from baseline in systemic and pulmonary hemodynamic parameters...
June 19, 2017: Pulmonary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28639575/account-for-clinical-heterogeneity-in-assessment-of-catheter-based-renal-denervation-among-resistant-hypertension-patients-subgroup-meta-analysis
#9
Xiao-Han Chen, Sehee Kim, Xiao-Xi Zeng, Zhi-Bing Chen, Tian-Lei Cui, Zhang-Xue Hu, Yi Li, Ping Fu
BACKGROUND: Catheter-based renal denervation (RDN) is a novel treatment for resistant hypertension (RH). A recent meta-analysis reported that RDN did not significantly reduce blood pressure (BP) based on the pooled effects with mild to severe heterogeneity. The aim of the present study was to identify and reduce clinical sources of heterogeneity and reassess the safety and efficacy of RDN within the identified homogeneous subpopulations. METHODS: This was a meta-analysis of 9 randomized clinical trials (RCTs) among patients with RH up to June 2016...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28639538/metabolic-syndrome-pathophysiology-management-and-modulation-by-natural-compounds
#10
Yogita Rochlani, Naga Venkata Pothineni, Swathi Kovelamudi, Jawahar L Mehta
Metabolic syndrome (MetS) represents a cluster of metabolic abnormalities that include hypertension, central obesity, insulin resistance, and atherogenic dyslipidemia, and is strongly associated with an increased risk for developing diabetes and atherosclerotic and nonatherosclerotic cardiovascular disease (CVD). The pathogenesis of MetS involves both genetic and acquired factors that contribute to the final pathway of inflammation that leads to CVD. MetS has gained significant importance recently due to the exponential increase in obesity worldwide...
June 1, 2017: Therapeutic Advances in Cardiovascular Disease
https://www.readbyqxmd.com/read/28638408/reanalysis-and-external-validation-of-a-decision-tree-model-for-detecting-unrecognized-diabetes-in-rural-chinese-individuals
#11
Zhong Xin, Lin Hua, Xu-Hong Wang, Dong Zhao, Cai-Guo Yu, Ya-Hong Ma, Lei Zhao, Xi Cao, Jin-Kui Yang
We reanalyzed previous data to develop a more simplified decision tree model as a screening tool for unrecognized diabetes, using basic information in Beijing community health records. Then, the model was validated in another rural town. Only three non-laboratory-based risk factors (age, BMI, and presence of hypertension) with fewer branches were used in the new model. The sensitivity, specificity, positive predictive value, negative predictive value, and area under the curve (AUC) for detecting diabetes were calculated...
2017: International Journal of Endocrinology
https://www.readbyqxmd.com/read/28638342/warfarin-anticoagulation-therapy-in-caribbean-hispanics-of-puerto-rico-a-candidate-gene-association-study
#12
Karla Claudio-Campos, Aurora Labastida, Alga Ramos, Andrea Gaedigk, Jessicca Renta-Torres, Dariana Padilla, Giselle Rivera-Miranda, Stuart A Scott, Gualberto Ruaño, Carmen L Cadilla, Jorge Duconge-Soler
Existing algorithms account for ~50% of observed variance in warfarin dose requirements after including common polymorphisms. However, they do not perform as well in populations other than Caucasians, in part because some ethno-specific genetic variants are overlooked. The objective of the present study was to identify genetic polymorphisms that can explain variability in warfarin dose requirements among Caribbean Hispanics of Puerto Rico. Next-Generation Sequencing of candidate genes CYP2C9 and VKORC1 and genotyping by DMET® Plus Assay of cardiovascular patients were performed...
2017: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/28637627/pulmonary-arterial-resistance-and-compliance-in-preterm-infants
#13
Seigo Okada, Jun Muneuchi, Yusaku Nagatomo, Mamie Watanabe, Chiaki Iida, Hiromitsu Shirouzu, Ryohei Matsuoka, Kunitaka Joo
BACKGROUND: Preterm birth is known to be associated with an increased risk of pulmonary arterial hypertension, although how preterm birth influences pulmonary hemodynamics has not been fully understood. Pulmonary arterial resistance (Rp) and compliance (Cp) are important factors to assess the pulmonary circulation. The purpose of this study is to clarify the relationship between Rp and Cp in preterm infants. METHODS: We performed cardiac catheterization in 96 infants (50 males) with ventricular septal defect, and compared pulmonary hemodynamic parameters including Rp and Cp between preterm and full-term infants...
June 16, 2017: International Journal of Cardiology
https://www.readbyqxmd.com/read/28637078/-update-cardiovascular-sleep-medicine
#14
Benedikt Linz, Michael Böhm, Dominik Linz
The prevalence of sleep-disordered breathing (SDB) is high in patients with cardiovascular diseases. Typical symptoms like daytime sleepiness can be absent and those patients may report unspecific, therapy-resistant symptoms related to their underlying disease. Particularly sleep-related symptoms like nocturia, nocturnal dyspnea and pectangina can be present. Based on the results of recently published studies, the treatment of central sleep apnea in patients with symptomatic, systolic heart failure by adaptive servo-ventilation is no longer recommended...
June 2017: Deutsche Medizinische Wochenschrift
https://www.readbyqxmd.com/read/28633352/aortopulmonary-window-results-of-repair-beyond-infancy%C3%A2
#15
Sachin Talwar, Bharat Siddharth, Saurabh Kumar Gupta, Shiv Kumar Choudhary, Shyam Sunder Kothari, Rajnish Juneja, Anita Saxena, Balram Airan
OBJECTIVES: To study the anatomic and haemodynamic data and results of surgery in patients undergoing surgical repair of aortopulmonary window beyond infancy. METHODS: Between July 2005 and December 2015, 23 patients, older than 1 year undergoing surgery for aortopulmonary window were analysed retrospectively. Postoperative clinical and echocardiography follow-up were performed. RESULTS: Median age and weight at repair was 4 years (range 14 months-12 years) and 12 kg (range 3...
June 13, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28630606/clinical-characteristics-target-organ-damage-and-associate-risk-factors-of-resistant-hypertension-determined-by-ambulatory-blood-pressure-monitoring-in-patients-aged-%C3%A2-80-years
#16
Zhi-Ru Liang, Ling-Gen Gao, Jian Cao, Hua Cui, Li Fan, De-Wei Gao
OBJECTIVES: To investigate clinical characteristics, target organ damage, and the associated risk factors of the patients aged ≥ 80 years with true resistant hypertension (RH). METHODS: Patients aged ≥ 80 years with hypertension (n = 1163) were included in this study. The included participants attended a structured clinical examination and an evaluation of RH was carried out. The prevalence, clinical characteristics and target organ damage of patients with RH were assessed...
May 2017: Journal of Geriatric Cardiology: JGC
https://www.readbyqxmd.com/read/28626080/cyp2c44-mediated-decrease-of-15-hete-exacerbates-pulmonary-hypertension
#17
Gábor Á Fülöp, Andriy Yabluchanskiy
Pulmonary hypertension (PH) is a progressive disease characterized by elevated pulmonary arterial pressure and pulmonary vascular resistance. According to latest estimations, a PH incidence accounts for 1% of total global population (up to 5 million people) and the median survival rate for patients diagnosed with PH is predicted at 2.8 years. Emerging evidence suggests an important role for cytochrome P450 in the development and progression of PH, as a newer member of cytochrome family Cyp2c44 has been recently implicated in mediating hypoxia-induced pulmonary artery remodeling...
June 16, 2017: American Journal of Physiology. Heart and Circulatory Physiology
https://www.readbyqxmd.com/read/28624040/hyperglycemia-attenuates-receptor-activator-of-nf-%C3%AE%C2%BAb-ligand-induced-macrophage-activation-by-suppressing-insulin-signaling
#18
Chitaru Kurihara, Teruyoshi Tanaka, Dai Yamanouchi
BACKGROUND: Although male gender, aging, hypertension, dyslipidemia, and smoking are common risk factors for abdominal aortic aneurysm, diabetes mellitus is an independent negative risk factor. In aneurysm tissue, matrix metalloproteinases (MMPs) expressed by activated macrophages degrades extracellular matrix proteins. In our previous experimental study, we demonstrated that the aneurysmal formation and macrophage activity were suppressed by inhibiting mimicking hyperglycemia (HG) through upregulation of glucose-sensing nuclear receptor, Nr1h2...
June 15, 2017: Journal of Surgical Research
https://www.readbyqxmd.com/read/28622477/an-examination-of-factors-affecting-the-length-of-stay-in-a-palliative-care-center
#19
Metin Dincer, Kadriye Kahveci, Cihan Doger
BACKGROUND: With the increase in elderly population, life-threatening chronic diseases are increasing, simultaneously increasing the need for palliative care centers (PCCs). OBJECTIVES: To evaluate the factors affecting the length of stay (LOS) and discharge of patients from a PCC. METHODS: A retrospective scan was made of the records of patients followed up in the PCC between January 2013 and March 2016. A record was made of patient age, gender, diagnosis, conditions/comorbidities, Glasgow Coma Scale, Karnofsky Performance Scale, LOS, prognosis (exitus or surviving), percutaneous endoscopic gastrostomy (PEG), tracheostomy, mechanical ventilator, nutrition (total parenteral nutrition [TPN] or enteral nutrition), and the results of cultures taken during stay in PCCs (blood, tracheal aspirate, urine, rectal swab, wound)...
June 16, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28622156/aerobic-versus-isometric-handgrip-exercise-in-hypertension-a-randomized-controlled-trial
#20
Nikolaos Pagonas, Stergios Vlatsas, Frederic Bauer, Felix S Seibert, Walter Zidek, Nina Babel, Peter Schlattmann, Timm H Westhoff
OBJECTIVES: Aerobic dynamic exercise reduces blood pressure (BP) and is broadly recommended by current American and European hypertension guidelines. Isometric exercise is currently not recommended, since data from only a few studies are available. We compare for the first time the effects of isometric handgrip training and aerobic exercise in a randomized controlled trial. METHODS: A total of 75 hypertensive patients were randomized to one of the following 12-week programmes: Isometric handgrip training five times weekly (two contractions of 2 min at 30% of maximal power with each arm); 'Sham-handgrip training' five times weekly (two contractions of 2 min at 5% of maximal power with each arm); Aerobic exercise training of 30 min three to five times per week...
June 15, 2017: Journal of Hypertension
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