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https://www.readbyqxmd.com/read/28069385/changes-of-renin-angiotensin-system-related-aminopeptidases-in-early-stage-alzheimer-s-disease
#1
Paul Richard Gard, Sara Fidalgo, Isabelle Lotter, Cassandra Richardson, Nicolas Farina, Jennifer Rusted, Naji Tabet
Activities of aminopeptidases A, B, and N (ApA, ApB & ApN) and insulin-regulated aminopeptidase (IRAP) have been seen to be decreased amongst patients with Alzheimer's disease (AD). All of these enzymes are involved with the brain renin-angiotensin system which is believed to be involved with learning and memory. This study aimed to explore the time course and the mechanisms underlying these changes. Serum samples were collected from 45 AD patients at the start of the study, and again 13months later (n=37)...
January 6, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28060317/observation-and-quantification-of-mating-behavior-in-the-pinewood-nematode-bursaphelenchus-xylophilus
#2
Najie Zhu, Liqun Bai, Stefan Schütz, Baojun Liu, Zhenyu Liu, Xingyao Zhang, Hongshi Yu, Jiafu Hu
A method for observing and quantifying the mating behavior of the pinewood nematode, Bursaphelenchus xylophilus, was established under a stereomicroscope. To improve the mating efficiency of B. Xylophilus and to increase the chances of mating observation, virgin adults were cultured and used for the investigation. Eggs were obtained by keeping the nematodes in water and allowing the females to lay eggs for 10 min. The second-stage juveniles (J2) were synchronized by incubating the eggs for 24 h at 25 °C in the dark, and the early J4 were obtained by culturing the J2 with grey mold, Botrytis cinerea, for another 52 h...
December 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059047/the-elusive-nature-of-apoe-%C3%AE%C2%B54-in-mid-adulthood-understanding-the-cognitive-profile
#3
Claire Lancaster, Naji Tabet, Jennifer Rusted
OBJECTIVES: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences in cognition in mid-adulthood, when detrimental effects of the allele may first be detectable. METHODS: Thirty-six papers investigating the behavioral effects of APOE ε4 in mid-adulthood (defined as a mean sample age between 35 and 60 years) were reviewed...
January 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28045690/clinical-case-of-the-month-a-49-year-old-man-who-presents-with-left-sided-weakness-an-update-on-ischemic-stroke
#4
Najy Masri, Rikki Weems, Falon Brown, Ben Andres, Fred Lopez
A 49 year-old man with a past medical history significant for essential hypertension, hyperlipidemia, and coronary artery disease status post percutaneous coronary intervention and stent placement in the right coronary artery in 2010 presented for evaluation of left hemiplegia. He was feeling well until three hours prior to presentation, at which time he fell while walking from his bedroom into the kitchen. After falling, he noticed that his left upper and lower extremities felt weak. He denied any symptoms preceding the fall or any loss of consciousness...
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28039790/degradation-photocatalysis-of-tetrodotoxin-as-a-poison-by-gold-doped-pdo-nanoparticles-supported-on-reduced-graphene-oxide-nanocomposites-and-evaluation-of-its-antibacterial-activity
#5
Ali Fakhri, Mahsa Naji
In this project, synthesis of pure and gold doped PdO-reduced graphene oxide nanocomposites by sonochemical and deposition-precipitation process was performed and characterized using X-ray diffraction (XRD), transmission electronic microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The specific surface area of synthesized un-doped and Au doped PdO-RGO nanocomposites is 83.2, 109.1m(2)g(-1) and total pore volume is 0.31, 0.40cm(3)g(-1), respectively. With Tetrodotoxin as a target pollutant, photocatalytic system of UV+photocatalyst+H2O2 was set up...
December 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28017199/effects-of-left-dlpfc-versus-right-ppc-tdcs-on-multiple-sclerosis-fatigue
#6
Moussa A Chalah, Naji Riachi, Rechdi Ahdab, Alaa Mhalla, Mohamed Abdellaoui, Alain Créange, Jean-Pascal Lefaucheur, Samar S Ayache
BACKGROUND AND OBJECTIVE: Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed to evaluate the effects of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, on such a challenging symptom. Our secondary outcomes included the assessment of tDCS impact on mood and attentional performance. METHODS: Ten fatigued MS patients were enrolled in a double-blind, sham-controlled, and cross-over study...
January 15, 2017: Journal of the Neurological Sciences
https://www.readbyqxmd.com/read/28006713/influence-of-sodalite-zeolite-infiltration-on-the-coefficient-of-thermal-expansion-and-bond-strength-of-all-ceramic-dental-prostheses
#7
Ghassan Abdul-Hamid Naji, Ros Anita Omar, Rosiyah Yahya
In all-ceramic systems, a high incidence of veneer chip-off has been reported in clinical studies. Coefficient of thermal expansion (CTE) behaviour is one of the factors that may increase residual stress in the interface and influence the veneer/core bond strength. Therefore, this study aimed to evaluate the effect of sodalite zeolite-infiltration on the CTE behaviour and bond strength of different all-ceramic prostheses. The case-study groups were synthesized sodalite zeolite-infiltrated alumina (IA-SOD) and synthesized sodalite zeolite-infiltrated zirconia-toughened alumina (ZTA) (IZ-SOD), while the control groups were glass-infiltrated alumina (IA-glass) and glass-infiltrated ZTA (IZ-glass)...
December 15, 2016: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28004304/changes-in-fasting-and-prandial-gut-and-adiposity-hormones-following-vertical-sleeve-gastrectomy-or-roux-en-y-gastric-bypass-an-18-month-prospective-study
#8
Naji Alamuddin, Marion L Vetter, Rexford S Ahima, Louise Hesson, Scott Ritter, Alyssa Minnick, Lucy F Faulconbridge, Kelly C Allison, David B Sarwer, Jesse Chittams, Noel N Williams, Matthew R Hayes, James W Loughead, Ruben Gur, Thomas A Wadden
BACKGROUND: Vertical sleeve gastrectomy (VSG) and Roux-en-Y gastric bypass (RYGB) produce substantial weight loss, both primarily through gastric restriction but with potentially different hormonal signaling. This prospective, observational study compared changes in gut-derived hormones in VSG, RYGB, and weight-stable participants at 6 and 18 months post-surgery. METHODS: Sixty-four obese, non-diabetic women, including 18 VSG, 23 RYGB, and 23 weight-stable controls completed assessments at baseline and 6 months, before and after consuming a mixed-nutrient meal; blood sampling occurred for 180 min post-meal...
December 21, 2016: Obesity Surgery
https://www.readbyqxmd.com/read/28004295/vitamin-d-status-correction-in-saudi-arabia-an-experts-consensus-under-the-auspices-of-the-european-society-for-clinical-and-economic-aspects-of-osteoporosis-osteoarthritis-and-musculoskeletal-diseases-esceo
#9
Nasser M Al-Daghri, Yousef Al-Saleh, Naji Aljohani, Riad Sulimani, Abdulaziz M Al-Othman, Hanan Alfawaz, Mona Fouda, Fahad Al-Amri, Awad Shahrani, Mohammed Alharbi, Fahad Alshahrani, Waleed Tamimi, Shaun Sabico, Rene Rizzoli, Jean-Yves Reginster
BACKGROUND: Vitamin D deficiency is common in the Middle East and in Saudi Arabia, in particular. While several international recommendations on the management of vitamin D deficiency have been documented and practiced globally, these recommendations should be adapted to the conditions of the Middle Eastern region. To address this challenge, the Prince Mutaib Chair for Biomarkers of Osteoporosis (PMCO) in King Saud University (KSU), Riyadh, KSA, together with local experts and in cooperation with the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO), organized a panel that formulated unified recommendations in the diagnosis and treatment of vitamin D deficiency in the region...
December 2017: Archives of Osteoporosis
https://www.readbyqxmd.com/read/27992972/protective-features-of-resveratrol-on-human-spermatozoa-cryopreservation-may-be-mediated-through-5-amp-activated-protein-kinase-activation
#10
M Shabani Nashtaei, F Amidi, M A Sedighi Gilani, A Aleyasin, Sh Bakhshalizadeh, M Naji, S Nekoonam
Biochemical and physical modifications during the freeze-thaw process adversely influence the restoration of energy-dependent sperm functions required for fertilization. Resveratrol, a phytoalexin, has been introduced to activate 5' AMP-activated protein kinase which is a cell energy sensor and a cell metabolism regulator. The cryoprotection of resveratrol on sperm cryoinjury via activation of AMP-activated protein kinase also remains to be elucidated. Our aim, thus, was to investigate: (i) the presence and intracellular localization of AMP-activated protein kinase protein; (ii) whether resveratrol may exert a protective effect on certain functional properties of fresh and post-thaw human spermatozoa through modulation of AMP-activated protein kinase...
December 19, 2016: Andrology
https://www.readbyqxmd.com/read/27987886/fabrication-of-basil-seed-gum-nanoparticles-as-a-novel-oral-delivery-system-of-glutathione
#11
Sara Naji-Tabasi, Seyed Mohammad Ali Razavi, Hossein Mehditabar
Plant derived polymers like mucilage have evoked great attention in the field of functional food ingredient delivery. The objective of this study was to evaluate the potential of basil seed gum nanoparticles (BSG NPs) as an oral delivery system for glutathione (GSH). BSG NPs (1-0.25mgml(-1)) were fabricated by ion gelling technique and calcium was used as a cross-linking agent (0.7-0.3mgml(-1)). The results showed that BSG NPs (298-595nm) have spherical shape and the relative viscosity revealed that the possibility of agglomeration of BSG NPs is low...
February 10, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/27981034/common-variation-of-the-cyp17-gene-in-iraqi-women-with-endometriosis-disease
#12
Salwa H N Al-Rubae'i, Tamara Sami Naji, Kisma M Turki
Common variants among genes coding for enzymes in sex steroid biosynthetic pathways may influence the risk of endometriosis in Iraqi women patients in the last years. Cytochrome P450c17a1 (CYP17), a gene that codes for a key enzyme (cytochrome P450c17a1) in a rate-limiting step of estrogen biosynthesis has attracted considerable attention as an important gene for endometriosis. To evaluate the relationship between common genetic variations in CYP17 and endometriosis risk and determine the main effects of those variations on the gene expression...
March 2017: Genomics Data
https://www.readbyqxmd.com/read/27941246/lim-domain-binding-1-maintains-the-terminally-differentiated-state-of-pancreatic-%C3%AE-cells
#13
Benjamin N Ediger, Hee-Woong Lim, Christine Juliana, David N Groff, LaQueena T Williams, Giselle Dominguez, Jin-Hua Liu, Brandon L Taylor, Erik R Walp, Vasumathi Kameswaran, Juxiang Yang, Chengyang Liu, Chad S Hunter, Klaus H Kaestner, Ali Naji, Changhong Li, Maike Sander, Roland Stein, Lori Sussel, Kyoung-Jae Won, Catherine Lee May, Doris A Stoffers
The recognition of β cell dedifferentiation in type 2 diabetes raises the translational relevance of mechanisms that direct and maintain β cell identity. LIM domain-binding protein 1 (LDB1) nucleates multimeric transcriptional complexes and establishes promoter-enhancer looping, thereby directing fate assignment and maturation of progenitor populations. Many terminally differentiated endocrine cell types, however, remain enriched for LDB1, but its role is unknown. Here, we have demonstrated a requirement for LDB1 in maintaining the terminally differentiated status of pancreatic β cells...
January 3, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27936010/new-insights-on-the-composition-and-the-structure-of-the-acellular-extrinsic-fiber-cementum-by-raman-analysis
#14
Thomas Colard, Guillaume Falgayrac, Benoit Bertrand, Stephan Naji, Olivier Devos, Clara Balsack, Yann Delannoy, Guillaume Penel
Acellular extrinsic fiber cementum is a mineralized tissue that covers the cervical half of the tooth root surface. It contains mainly extrinsic or Sharpey's fibers that run perpendicular to the root surface to anchor the tooth via the periodontal ligament. Acellular cementum is continuously and slowly produced throughout life and exhibits an alternating bright and dark pattern under light microscopy. However, although a better understanding of the structural background of acellular cementum is relevant to many fields, such as cementochronology, periodontology and tissue engineering, acellular cementum remains rarely studied and poorly understood...
2016: PloS One
https://www.readbyqxmd.com/read/27930952/prevalence-and-psychosocial-correlates-of-food-addiction-in-persons-with-obesity-seeking-weight-reduction
#15
Ariana M Chao, Jena A Shaw, Rebecca L Pearl, Naji Alamuddin, Christina M Hopkins, Zayna M Bakizada, Robert I Berkowitz, Thomas A Wadden
INTRODUCTION: Food addiction is a controversial concept. The potential influence of food addiction on patients' psychosocial functioning and well-being has not been well established. The purpose of this study was to examine the relationships between psychosocial functioning (depressive symptoms and health-related quality of life [HRQOL]) and food addiction as measured by the Yale Food Addiction Scale (YFAS). We also explored whether food addiction contributed additional variance in explaining psychosocial functioning, beyond demographic and clinical factors (e...
November 23, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/27903153/management-of-obesity
#16
Naji Alamuddin, Zayna Bakizada, Thomas A Wadden
This review examines weight loss and accompanying improvements in obesity-related comorbidities produced by intensive lifestyle intervention, pharmacotherapy, and bariatric surgery. Obese individuals lose approximately 6 to 8 kg (approximately 6% to 8% of initial weight) with 6 months of participation in a high-intensity lifestyle intervention (≥ 14 treatment visits) consisting of diet, physical activity, and behavior therapy. Such losses reduce progression to type 2 diabetes in at-risk people and decrease blood pressure and triglyceride levels...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27903071/reduced-levels-and-bioactivity-of-endogenous-protease-cathepsin-d-in-genital-tract-secretions-of-postmenopausal-women
#17
Mariel Jais, Naji Younes, Stacey Chapman, Susan Cu-Uvin, Mimi Ghosh
PROBLEM: HIV infections are increasing in older adult populations. Although it is known that the HIV/AIDS epidemics affect women disproportionately, little is known regarding immune responses in reproductive tract of postmenopausal women, specifically regarding endogenous proteases that modulate inflammation, tissue remodeling and wound healing. METHOD OF STUDY: Levels and bioactivity of endogenous proteases Cathepsin B, D, G, and Neutrophil Elastase were measured in cervical vaginal lavage collected from 20 HIV-negative pre- and postmenopausal women...
November 30, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27894723/plastic-debris-and-microplastics-along-the-beaches-of-the-strait-of-hormuz-persian-gulf
#18
Abolfazl Naji, Zinat Esmaili, Farhan R Khan
Currently little is known about the prevalence of plastics and microplastics (MPs) in the Persian Gulf. Five sampling stations were selected along the Strait of Hormuz (Iran) that exhibited different levels of industrialization and urbanization, and included a marine protected area. Debris was observed and sediments were collected for MPs extraction via fluidization/floatation methodology. The order of MP abundance (par/kg) generally reflected the level of anthropogenic activity: Bostanu (1258±291)>Gorsozan (122±23)>Khor-e-Yekshabeh (26±6)>Suru (14±4)>Khor-e-Azini (2±1)...
November 25, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27864812/how-in-vitro-assays-contribute-to-allergy-diagnosis
#19
REVIEW
Anne Casset, Naji Khayath, Frédéric de Blay
Diagnosis of allergic disorders is based upon the clinical history of the disease, the immunoglobulin E (IgE) antibody response, and the allergen exposure. During the last decade, many changes have occurred in the in vitro diagnostic tests used in daily practice. The most important one is the use of allergenic molecules, which helps to define severe profile of allergy and/or to better understand cross-reactivity. The correlation between IgE sensitization and bronchial or nasal response in provocation tests is not so clear, which implies that such tests are still helpful in allergy diagnosis...
November 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27843768/functional-alterations-due-to-amino-acid-changes-and-evolutionary-comparative-analysis-of-arpkd-and-adpkd-genes
#20
Burhan M Edrees, Mohammad Athar, Zainularifeen Abduljaleel, Faisal A Al-Allaf, Mohiuddin M Taher, Wajahatullah Khan, Abdellatif Bouazzaoui, Naffaa Al-Harbi, Ramzia Safar, Howaida Al-Edressi, Khawala Alansary, Abulkareem Anazi, Naji Altayeb, Muawia A Ahmed
A targeted customized sequencing of genes implicated in autosomal recessive polycystic kidney disease (ARPKD) phenotype was performed to identify candidate variants using the Ion torrent PGM next-generation sequencing. The results identified four potential pathogenic variants in PKHD1 gene [c.4870C > T, p.(Arg1624Trp), c.5725C > T, p.(Arg1909Trp), c.1736C > T, p.(Thr579Met) and c.10628T > G, p.(Leu3543Trp)] among 12 out of 18 samples. However, one variant c.4870C > T, p.(Arg1624Trp) was common among eight patients...
December 2016: Genomics Data
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