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https://www.readbyqxmd.com/read/29781950/report-of-the-key-opinion-leaders-meeting-on-stem-cell-derived-beta-cells
#1
Jon Odorico, James Markmann, Douglas Melton, Julia Greenstein, Albert Hwa, Cristina Nostro, Alireza Rezania, Jose Oberholzer, Daniel Pipeleers, Luhan Yang, Chad Cowan, Danwei Huangfu, Dieter Egli, Uri Ben-David, Ludovic Vallier, Shane T Grey, Qizhi Tang, Bart Roep, Camilo Ricordi, Ali Naji, Giuseppe Orlando, Daniel G Anderson, Mark Poznansky, Barbara Ludwig, Alice Tomei, Dale L Greiner, Melanie Graham, Melissa Carpenter, Giovanni Migliaccio, Kevin D'Amour, Bernhard Hering, Lorenzo Piemonti, Thierry Berney, Mike Rickels, Thomas Kay, Ann Adams
Beta cell replacement has the potential to restore euglycemia in patients with insulin dependent diabetes. While great progress has been made in establishing allogeneic islet transplantation from deceased donors as the standard of care for those with the most labile diabetes, it is also clear that the deceased donor organ supply cannot possibly treat all those who could benefit from restoration of a normal beta cell mass, especially if immunosuppression were not required. Against this background, the International Pancreas and Islet Transplant Association (IPITA) in collaboration with the Harvard Stem Cell Institute (HSCI), the Juvenile Diabetes Research Foundation (JDRF), and the Helmsley Foundation held a 2-day Key Opinion Leaders Meeting in Boston in 2016 to bring together experts in generating and transplanting beta cells derived from stem cells...
April 30, 2018: Transplantation
https://www.readbyqxmd.com/read/29780848/controlled-human-hookworm-infection-accelerating-human-hookworm-vaccine-development
#2
David Diemert, Doreen Campbell, Jill Brelsford, Caitlyn Leasure, Guangzhao Li, Jin Peng, Maria Zumer, Naji Younes, Maria Elena Bottazzi, Rojelio Mejia, David I Pritchard, John M Hawdon, Jeffrey M Bethony
Background: Controlled human hookworm infection (CHHI) is a central component of a proposed hookworm vaccination-challenge model (HVCM) to test the efficacy of candidate vaccines. Critical to CHHI is the manufacture of Necator americanus infective larvae ( Na L3) according to current Good Manufacturing Practice (cGMP) and the determination of an inoculum of Na L3 that is safe and reliably induces patent infection. Methods: cGMP-grade Na L3 were produced for a phase 1 trial in 20 healthy, hookworm-naïve adults in the United States, who received either 25 or 50 Na L3...
May 2018: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/29755605/the-prevalence-of-osteopenia-and-osteoporosis-among-malaysian-type-2-diabetic-patients-using-quantitative-ultrasound-densitometer
#3
Shaymaa Abdalwahed Abdulameer, Mohanad Naji Sahib, Syed Azhar Syed Sulaiman
Background: Type 2 Diabetes Mellitus (T2DM) and osteoporosis are both chronic conditions and the relationship between them is complex. Objective: The aims of this study were to assess the prevalence of Low Bone Mineral density (LBMD, i.e ., osteopenia and osteoporosis), as well as, the difference and associations between Quantitative Ultrasound Scan (QUS) parameters with socio-demographic data and clinical related data among T2DM in Penang, Malaysia. Method: An observational, cross-sectional study with a convenient sample of 450 T2DM patients were recruited from the outpatient diabetes clinic at Hospital Pulau Pinang (HPP) to measure Bone Mineral Density (BMD) at the heel bone using QUS...
2018: Open Rheumatology Journal
https://www.readbyqxmd.com/read/29753853/chloral-hydrate-administered-by-a-dedicated-sedation-service-can-be-used-safely-and-effectively-for-pediatric-ophthalmic-examination
#4
Mohammed Karaoui, Varshini Varadaraj, Beatriz Munoz, Megan E Collins, Leyla Al Djasim, Esam Al Naji, Karam Hamweyah, Mohammed Al Shamrani, Earl Randy Craven, David S Friedman
PURPOSE: To determine safety and efficacy of oral chloral hydrate sedation (CHS) for outpatient pediatric ophthalmic procedures. DESIGN: Prospective, interventional case series METHODS-SETTING: - King Khaled Eye Specialist Hospital. SUBJECTS: Children ages 1 month to 5 years undergoing CHS for ocular imaging/evaluation PROCEDURES: Details on chloral hydrate dose administered, sedation achieved, vitals, and adverse events were recorded OUTCOME MEASURES: Primary Outcome: Percent of patients with a sedation level ≥4 at 45 minutes post chloral hydrate administration...
May 10, 2018: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/29749659/roles-of-methyltrienolone-r1881-in-akts-and-ar-expression-patterns-of-cultured-granulosa-lutein-cells
#5
Saeid Nekoonam, Mohammad Naji, Keywan Mortezaee, Fardin Amidi
AR-mediated androgen signaling plays a key role in female reproductive system. Granulosa-lutein cells (GCs) are the main sites for expression of androgen receptor (AR). There is also a close relation between AKT signaling and AR. Here, we assayed the role for a synthetic AR ligand methyltrienolone (R1881) in expressions of AKTs and AR. Controlled ovarian hyperstimulation (COH) was performed in 20 normal women. Mural GCs were isolated by filtration method, cultured, and passaged. Then, the cells were starved for 48 h with 10% charcoal stripped FBS...
May 11, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29736759/in-vitro-impact-of-laser-irradiation-on-platelet-aggregation
#6
Eman A Shakir, Nabaa A Rasheed Naji
The review of blood optical and rheological parameters plays an important role in many medical routine diagnosis and therapeutic applications and is the best way to understand the mechanism of action of low-level laser irradiation on biological tissues. The aim of this study was to investigate the in vitro effect of laser radiation on platelet count and aggregation. Blood samples were obtained from 30 healthy volunteers; each sample was divided into four aliquots, one of them was considered as a control while the other three were exposed to three different laser doses...
May 7, 2018: Lasers in Medical Science
https://www.readbyqxmd.com/read/29731398/cholera-epidemic-in-yemen-2016-18-an-analysis-of-surveillance-data
#7
Anton Camacho, Malika Bouhenia, Reema Alyusfi, Abdulhakeem Alkohlani, Munna Abdulla Mohammed Naji, Xavier de Radiguès, Abdinasir M Abubakar, Abdulkareem Almoalmi, Caroline Seguin, Maria Jose Sagrado, Marc Poncin, Melissa McRae, Mohammed Musoke, Ankur Rakesh, Klaudia Porten, Christopher Haskew, Katherine E Atkins, Rosalind M Eggo, Andrew S Azman, Marije Broekhuijsen, Mehmet Akif Saatcioglu, Lorenzo Pezzoli, Marie-Laure Quilici, Abdul Rahman Al-Mesbahy, Nevio Zagaria, Francisco J Luquero
BACKGROUND: In war-torn Yemen, reports of confirmed cholera started in late September, 2016. The disease continues to plague Yemen today in what has become the largest documented cholera epidemic of modern times. We aimed to describe the key epidemiological features of this epidemic, including the drivers of cholera transmission during the outbreak. METHODS: The Yemen Health Authorities set up a national cholera surveillance system to collect information on suspected cholera cases presenting at health facilities...
May 3, 2018: Lancet Global Health
https://www.readbyqxmd.com/read/29729793/imaging-of-hallux-valgus-how-to-approach-the-deformity
#8
REVIEW
Matthew James Welck, Naji Al-Khudairi
This article describes the pathogenesis of hallux valgus (HV) and the traditional ways to image the deformities. It also discusses up-to-date advances and research in the field of imaging in HV. This includes weight-bearing computed tomography (CT) scanning, MRI, ultrasound and intraoperative imaging.
June 2018: Foot and Ankle Clinics
https://www.readbyqxmd.com/read/29713431/effects-of-incorporation-of-2-5-and-5-wt-tio-2-nanotubes-on-fracture-toughness-flexural-strength-and-microhardness-of-denture-base-poly-methyl-methacrylate-pmma
#9
Sahar Abdulrazzaq Naji, Marjan Behroozibakhsh, Tahereh Sadat Jafarzadeh Kashi, Hossein Eslami, Reza Masaeli, Hosseinali Mahgoli, Mohammadreza Tahriri, Mehrsima Ghavvami Lahiji, Vahid Rakhshan
PURPOSE: The aim of this preliminary study was to investigate, for the first time, the effects of addition of titania nanotubes (n-TiO2 ) to poly methyl methacrylate (PMMA) on mechanical properties of PMMA denture base. MATERIALS AND METHODS: TiO2 nanotubes were prepared using alkaline hydrothermal process. Obtained nanotubes were assessed using FESEM-EDX, XRD, and FT-IR. For 3 experiments of this study (fracture toughness, three-point bending flexural strength, and Vickers microhardness), 135 specimens were prepared according to ISO 20795-1:2013 (n of each experiment=45)...
April 2018: Journal of Advanced Prosthodontics
https://www.readbyqxmd.com/read/29698760/statistical-optimization-and-operational-stability-of-rhizomucor-miehei-lipase-supported-on-magnetic-chitosan-chitin-nanoparticles-for-synthesis-of-pentyl-valerate
#10
Ida Nurhazwani Abdul Rahman, Nursyafreena Attan, Naji Arafat Mahat, Joazaizulfazli Jamalis, Aemi S Abdul Keyon, Cepi Kurniawan, Roswanira Abdul Wahab
The chemical-catalyzed transesterification process to produce biofuels i.e. pentyl valerate (PeVa) is environmentally unfriendly, energy-intensive with tedious downstream treatment. The present work reports the use of Rhizomucor miehei lipase (RML) crosslinked onto magnetic chitosan/chitin nanoparticles (RML-CS/CH/MNPs). The approach used to immobilize RML onto the CS/CH/MNPs yielded RML-CS/CH/MNPs with an immobilized protein loading and specific activity of 7.6 mg/g and 5.0 U·g-1 , respectively. This was confirmed by assessing data of field emission scanning electron microscopy, X-ray diffraction, thermal gravimetric analysis and Fourier transform infrared spectroscopy...
April 23, 2018: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/29692699/a-control-scheme-that-uses-dynamic-postural-synergies-to-coordinate-a-hybrid-walking-neuroprosthesis-theory-and-experiments
#11
Naji A Alibeji, Vahidreza Molazadeh, Brad E Dicianno, Nitin Sharma
A hybrid walking neuroprosthesis that combines functional electrical stimulation (FES) with a powered lower limb exoskeleton can be used to restore walking in persons with paraplegia. It provides therapeutic benefits of FES and torque reliability of the powered exoskeleton. Moreover, by harnessing metabolic power of muscles via FES, the hybrid combination has a potential to lower power consumption and reduce actuator size in the powered exoskeleton. Its control design, however, must overcome the challenges of actuator redundancy due to the combined use of FES and electric motor...
2018: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/29676530/short-and-long-term-changes-in-health-related-quality-of-life-with-weight-loss-results-from-a-randomized-controlled-trial
#12
Rebecca L Pearl, Thomas A Wadden, Jena Shaw Tronieri, Robert I Berkowitz, Ariana M Chao, Naji Alamuddin, Sharon M Leonard, Raymond Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: The objective of this study was to determine the effects of weight loss and weight loss maintenance (WLM) on weight-specific health-related quality of life in a 66-week trial. METHODS: Adults with obesity (N = 137, 86.1% female, 68.6% black, mean age = 46.1 years) who had lost ≥ 5% of initial weight in a 14-week intensive lifestyle intervention/low-calorie diet (LCD) program were randomly assigned to lorcaserin or placebo for an additional 52-week WLM program...
April 20, 2018: Obesity
https://www.readbyqxmd.com/read/29673730/early-oocyte-denudation-does-not-compromise-icsi-cycle-outcome-a-large-retrospective-cohort-study
#13
Osama Naji, Natalie Moska, Yaser Dajani, Awatuf El-Shirif, Hassan El-Ashkar, Mohamed Hosni, Mohamed Khalil, Yacoub Khalaf, Virginia Bolton, Tarek El-Toukhy
This retrospective cohort study of 2051 consecutive fresh non-donor intracytoplasmic sperm injection (ICSI) cycles investigated whether time from oocyte retrieval to denudation, precisely measured and recorded by an operator-independent automated radiofrequency-based system, affected cycle outcome. ICSI cycles were divided into two groups: group I (denudation within <2 h of oocyte retrieval, n = 1118) and group II (denudation 2-5 h after oocyte retrieval, n = 933). Univariate analysis by two-sample t-test or Mann-Whitney test was used, as appropriate...
April 4, 2018: Reproductive Biomedicine Online
https://www.readbyqxmd.com/read/29671652/effects-of-educated-monocytes-with-xenogeneic-mesenchymal-stem-cell-derived-conditioned-medium-in-a-mouse-model-of-chronic-asthma
#14
Hadi Esmaili Gourvarchin Galeh, Seyyed Meysam Abtahi Froushani, Nahideh Afzale Ahangaran, Siamak Naji Hadai
BACKGROUND: This study was conducted to determine the potential of the monocytes educated with rat bone marrow mesenchymal stem cell-derived conditioned medium (MCM) in ameliorating animal model of asthma. METHODS: Chronic asthma was induced in the BALB/c mice using ovalbumin (OVA) sensitization. The monocytes were isolated from blood of mice and supplemented with 50% MCM or negative control media. After 24 h, the cells were designated as "non-educated or educated"...
April 19, 2018: Immunological Investigations
https://www.readbyqxmd.com/read/29665038/safety-and-feasibility-of-outpatient-rabbit-antithymocyte-globulin-induction-therapy-administration-in-kidney-transplant-recipients
#15
Alexandra N Varga, David Johnson, Deirdre L Sawinski, Mary Ann Lim, Roy D Bloom, Peter L Abt, Simin Goral, Melissa Bleicher, Matthew H Levine, Ali Naji, Susanna Nazarian, Paige Porrett, Jennifer Trofe-Clark
BACKGROUND: Kidney transplant induction therapy often includes inpatient administration of rabbit antithymocyte globulin (rATG) over multiple days. To reduce hospital length of stay (LOS) and drug expenditures, the rATG induction course was completed in the outpatient setting via peripheral intravenous administration. The present study assesses early readmission trends ascribable to an outpatient rATG administration protocol to assure initial reduction in hospital LOS is sustained early after discharge...
April 17, 2018: Pharmacotherapy
https://www.readbyqxmd.com/read/29656285/sociocultural-and-familial-factors-associated-with-weight-bias-internalization
#16
Rebecca L Pearl, Thomas A Wadden, Jena Shaw Tronieri, Ariana M Chao, Naji Alamuddin, Zayna M Bakizada, Emilie Pinkasavage, Robert I Berkowitz
BACKGROUND/AIMS: Sociocultural and familial factors associated with weight bias internalization (WBI) are currently unknown. The present study explored the relationship between interpersonal sources of weight stigma, family weight history, and WBI. METHODS: Participants with obesity (N = 178, 87.6% female, 71.3% black) completed questionnaires that assessed the frequency with which they experienced weight stigma from various interpersonal sources. Participants also reported the weight status of their family members and completed measures of WBI, depression, and demographics...
April 14, 2018: Obesity Facts
https://www.readbyqxmd.com/read/29652923/limited-immune-surveillance-in-lymphoid-tissue-by-cytolytic-cd4-t-cells-during-health-and-hiv-disease
#17
Marcus Buggert, Son Nguyen, Laura M McLane, Maria Steblyanko, Nadia Anikeeva, Dominic Paquin-Proulx, Perla M Del Rio Estrada, Yuria Ablanedo-Terrazas, Kajsa Noyan, Morgan A Reuter, Korey Demers, Johan Sandberg, Michael A Eller, Hendrik Streeck, Marianne Jansson, Piotr Nowak, Anders Sönnerborg, David H Canaday, Ali Naji, E John Wherry, Merlin Robb, Steven G Deeks, Gustavo Reyes-Teran, Yuri Sykulev, Annika C Karlsson, Michael R Betts
CD4+ T cells subsets have a wide range of important helper and regulatory functions in the immune system. Several studies have specifically suggested that circulating effector CD4+ T cells may play a direct role in control of HIV replication through cytolytic activity or autocrine β-chemokine production. However, it remains unclear whether effector CD4+ T cell populations expressing cytolytic molecules and β-chemokines are present within lymph nodes (LNs), a major site of HIV replication. Here, we report that expression of β-chemokines and cytolytic molecules are enriched within a CD4+ T cell population with high levels of the T-box transcription factors T-bet and eomesodermin (Eomes)...
April 13, 2018: PLoS Pathogens
https://www.readbyqxmd.com/read/29628739/maxillary-lateral-incisor-agenesis-a-retrospective-cross-sectional-study
#18
Naji Ziad Arandi, Shockry Mustafa
Objective: This study aims to estimate the prevalence of congenitally missing lateral incisors in a sample of 2662 dental patients in Palestine. Methods: A total of 2662 digital panoramic radiographs were retrospectively examined for the presence of congenitally missing permanent lateral incisors. The radiographs were obtained from the archival records of patients attending a local dental center at the city of Nablus in Palestine. Results: The prevalence of missing lateral incisors among the examined population (n = 2662) was found to be 1...
April 2018: Saudi Dental Journal
https://www.readbyqxmd.com/read/29617218/computational-model-of-brainstem-circuit-for-state-dependent-control-of-hypoglossal-motoneurons
#19
Mohsen Naji, Maxim Komarov, Giri P Krishnan, Atul Malhotra, Frank L Powell, Irma Rukhadze, Victor B Fenik, Maxim Bazhenov
In patients with obstructive sleep apnea (OSA) the pharyngeal muscles become relaxed during sleep, which leads to a partial or complete closure of upper airway. Experimental studies suggest that withdrawal of noradrenergic and serotonergic drives importantly contribute to depression of hypoglossal motoneurons and, therefore, may contribute to OSA pathophysiology; however, specific cellular and synaptic mechanisms remain unknown. In this new study, we developed a biophysical network model to test the hypothesis that, in order to explain experimental observations, the neuronal network for monoaminergic control of excitability of hypoglossal motoneurons needs to include excitatory and inhibitory perihypoglossal interneurons that mediate noradrenergic and serotonergic drives to hypoglossal motoneurons...
April 4, 2018: Journal of Neurophysiology
https://www.readbyqxmd.com/read/29580368/anaerobacillus-isosaccharinicus-sp-nov-an-alkaliphilic-bacterium-which-degrades-isosaccharinic-acid
#20
Naji M Bassil, Jonathan R Lloyd
Strain NB2006T was isolated from an isosaccharinate-degrading, nitrate-reducing enrichment culture in minimal freshwater medium at pH 10. Analysis of the 16S rRNA gene sequence indicated that this strain was most closely related to species of the newly established genus Anaerobacillus. This was supported by phenotypic and metabolic characterisation that showed that NB2006T was rod-shaped, Gram-stain-positive, motile and formed endospores. It was an aerotolerant anaerobe and an obligate alkaliphile that grew at pH 8...
March 26, 2018: International Journal of Systematic and Evolutionary Microbiology
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