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https://www.readbyqxmd.com/read/27903153/management-of-obesity
#1
Naji Alamuddin, Zayna Bakizada, Thomas A Wadden
This review examines weight loss and accompanying improvements in obesity-related comorbidities produced by intensive lifestyle intervention, pharmacotherapy, and bariatric surgery. Obese individuals lose approximately 6 to 8 kg (approximately 6% to 8% of initial weight) with 6 months of participation in a high-intensity lifestyle intervention (≥ 14 treatment visits) consisting of diet, physical activity, and behavior therapy. Such losses reduce progression to type 2 diabetes in at-risk people and decrease blood pressure and triglyceride levels...
December 10, 2016: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/27903071/reduced-levels-and-bioactivity-of-endogenous-protease-cathepsin-d-in-genital-tract-secretions-of-postmenopausal-women
#2
Mariel Jais, Naji Younes, Stacey Chapman, Susan Cu-Uvin, Mimi Ghosh
PROBLEM: HIV infections are increasing in older adult populations. Although it is known that the HIV/AIDS epidemics affect women disproportionately, little is known regarding immune responses in reproductive tract of postmenopausal women, specifically regarding endogenous proteases that modulate inflammation, tissue remodeling and wound healing. METHOD OF STUDY: Levels and bioactivity of endogenous proteases Cathepsin B, D, G, and Neutrophil Elastase were measured in cervical vaginal lavage collected from 20 HIV-negative pre- and postmenopausal women...
November 30, 2016: AIDS Research and Human Retroviruses
https://www.readbyqxmd.com/read/27894723/plastic-debris-and-microplastics-along-the-beaches-of-the-strait-of-hormuz-persian-gulf
#3
Abolfazl Naji, Zinat Esmaili, Farhan R Khan
Currently little is known about the prevalence of plastics and microplastics (MPs) in the Persian Gulf. Five sampling stations were selected along the Strait of Hormuz (Iran) that exhibited different levels of industrialization and urbanization, and included a marine protected area. Debris was observed and sediments were collected for MPs extraction via fluidization/floatation methodology. The order of MP abundance (par/kg) generally reflected the level of anthropogenic activity: Bostanu (1258±291)>Gorsozan (122±23)>Khor-e-Yekshabeh (26±6)>Suru (14±4)>Khor-e-Azini (2±1)...
November 25, 2016: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/27864812/how-in-vitro-assays-contribute-to-allergy-diagnosis
#4
REVIEW
Anne Casset, Naji Khayath, Frédéric de Blay
Diagnosis of allergic disorders is based upon the clinical history of the disease, the immunoglobulin E (IgE) antibody response, and the allergen exposure. During the last decade, many changes have occurred in the in vitro diagnostic tests used in daily practice. The most important one is the use of allergenic molecules, which helps to define severe profile of allergy and/or to better understand cross-reactivity. The correlation between IgE sensitization and bronchial or nasal response in provocation tests is not so clear, which implies that such tests are still helpful in allergy diagnosis...
November 2016: Current Allergy and Asthma Reports
https://www.readbyqxmd.com/read/27843768/functional-alterations-due-to-amino-acid-changes-and-evolutionary-comparative-analysis-of-arpkd-and-adpkd-genes
#5
Burhan M Edrees, Mohammad Athar, Zainularifeen Abduljaleel, Faisal A Al-Allaf, Mohiuddin M Taher, Wajahatullah Khan, Abdellatif Bouazzaoui, Naffaa Al-Harbi, Ramzia Safar, Howaida Al-Edressi, Khawala Alansary, Abulkareem Anazi, Naji Altayeb, Muawia A Ahmed
A targeted customized sequencing of genes implicated in autosomal recessive polycystic kidney disease (ARPKD) phenotype was performed to identify candidate variants using the Ion torrent PGM next-generation sequencing. The results identified four potential pathogenic variants in PKHD1 gene [c.4870C > T, p.(Arg1624Trp), c.5725C > T, p.(Arg1909Trp), c.1736C > T, p.(Thr579Met) and c.10628T > G, p.(Leu3543Trp)] among 12 out of 18 samples. However, one variant c.4870C > T, p.(Arg1624Trp) was common among eight patients...
December 2016: Genomics Data
https://www.readbyqxmd.com/read/27832687/subarachnoid-space-transplantation-of-schwann-and-or-olfactory-ensheathing-cells-following-severe-spinal-cord-injury-fails-to-improve-locomotor-recovery-in-rats
#6
Mohsen Nategh, Masoumeh Firouzi, Mehdi Naji-Tehrani, Leila Oryadi Zanjani, Zahra Hassannejad, Mohammad Hosein Nabian, Shayan Abdollah Zadegan, Mehrbod Karimi, Vafa Rahimi-Movaghar
Treatment of spinal cord injury by exogenous cells has brought both successful and unsuccessful results. Olfactory ensheathing cells and Schwann cells have been widely used for transplantation purposes. In this study, we investigated the effects of these cells on contused spinal cord by introducing cells into subarachnoid space. Fifty thousand Schwann cells or olfactory ensheathing cells or a mixture of both cell types were transplanted one week after a 3-second clip compression injury at T-9 spinal cord level in rats...
September 2016: Acta Medica Iranica
https://www.readbyqxmd.com/read/27809625/knowledge-and-attitudes-towards-dementia-in-adolescent-students
#7
Mokhtar G E K N Isaac, Maria M Isaac, Nicolas Farina, Naji Tabet
BACKGROUND: Improving people's knowledge, perceptions and attitudes of dementia is important in the formation of dementia-friendly communities. However, at present, there is very little evidence from adolescents, who are already the junior members of such communities and will be carers in their own rights in the future. Our aim was to evaluate adolescents' knowledge and attitudes of dementia. METHODS: Four-hundred and fifty adolescents, aged 15-18 years, from schools in Sussex (UK) were invited to complete a series of questions that assessed their dementia knowledge and attitudes...
November 4, 2016: Journal of Mental Health
https://www.readbyqxmd.com/read/27806497/the-interaction-of-c-reactive-protein-bisphenol-a-cardiovascular-disease-a-demographical-analysis
#8
Hassan Naji
OBJECTIVE: The main objective of the study was to investigate the role of C-reactive protein on the relationship between Bisphenol A & Cardiovascular Disease, where the C-reactive protein has been taken as a moderating variable. METHODS: Quantitative research design has been incorporated for evaluating the role of C-reactive protein. Similarly, non-parametric Spearman correlation test has been conducted to assess the relationship between BPA and CVD. The data was taken out from the National Health and Nutrition Examination Survey (NHANES), which was collected in the year 2009-2010...
July 12, 2016: Global Journal of Health Science
https://www.readbyqxmd.com/read/27798614/analysis-of-self-antigen-specificity-of-islet-infiltrating-t-cells-from-human-donors-with-type-1-diabetes
#9
Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett, Inne Crèvecoeur, Thomas S Buttrick, René Maehr, Rita Bottino, Ali Naji, John Kaddis, Wassim Elyaman, Eddie A James, Rachana Haliyur, Marcela Brissova, Lut Overbergh, Chantal Mathieu, Thomas Delong, Kathryn Haskins, Alberto Pugliese, Martha Campbell-Thompson, Clayton Mathews, Mark A Atkinson, Alvin C Powers, David M Harlan, Sally C Kent
A major therapeutic goal for type 1 diabetes (T1D) is to induce autoantigen-specific tolerance of T cells. This could suppress autoimmunity in those at risk for the development of T1D, as well as in those with established disease who receive islet replacement or regeneration therapy. Because functional studies of human autoreactive T cell responses have been limited largely to peripheral blood-derived T cells, it is unclear how representative the peripheral T cell repertoire is of T cells infiltrating the islets...
December 2016: Nature Medicine
https://www.readbyqxmd.com/read/27794149/microleakage-of-glass-ionomer-based-provisional-cement-in-cad-cam-fabricated-interim-crowns-an-in-vitro-study
#10
Ra'fat I Farah, Naji Al-Harethi
AIM: The aim of this study was to compare in vitro the marginal microleakage of glass ionomer-based provisional cement with resin-based provisional cement and zinc oxide non-eugenol (ZONE) provisional cement in computer-aided design and computer-aided manufacturing (CAD/CAM)-fabricated interim restorations. MATERIALS AND METHODS: Fifteen intact human premolars were prepared in a standardized manner for complete coverage of crown restorations. Interim crowns for the prepared teeth were then fabricated using CAD/CAM, and the specimens were randomized into three groups of provisional cementing agents (n = 5 each): Glass ionomer-based provisional cement (GC Fuji TEMP LT™), bisphenol-A-glycidyldimethacrylate (Bis-GMA)/ triethylene glycol dimethacrylate (TEGDMA) resin-based cement (UltraTemp® REZ), and ZONE cement (TempBond NE)...
October 1, 2016: Journal of Contemporary Dental Practice
https://www.readbyqxmd.com/read/27792790/phactr1-is-a-genetic-susceptibility-locus-for-fibromuscular-dysplasia-supporting-its-complex-genetic-pattern-of-inheritance
#11
Soto Romuald Kiando, Nathan R Tucker, Luis-Jaime Castro-Vega, Alexander Katz, Valentina D'Escamard, Cyrielle Tréard, Daniel Fraher, Juliette Albuisson, Daniella Kadian-Dodov, Zi Ye, Erin Austin, Min-Lee Yang, Kristina Hunker, Cristina Barlassina, Daniele Cusi, Pilar Galan, Jean-Philippe Empana, Xavier Jouven, Anne-Paule Gimenez-Roqueplo, Patrick Bruneval, Esther Soo Hyun Kim, Jeffrey W Olin, Heather L Gornik, Michel Azizi, Pierre-François Plouin, Patrick T Ellinor, Iftikhar J Kullo, David J Milan, Santhi K Ganesh, Pierre Boutouyrie, Jason C Kovacic, Xavier Jeunemaitre, Nabila Bouatia-Naji
Fibromuscular dysplasia (FMD) is a nonatherosclerotic vascular disease leading to stenosis, dissection and aneurysm affecting mainly the renal and cerebrovascular arteries. FMD is often an underdiagnosed cause of hypertension and stroke, has higher prevalence in females (~80%) but its pathophysiology is unclear. We analyzed ~26K common variants (MAF>0.05) generated by exome-chip arrays in 249 FMD patients and 689 controls. We replicated 13 loci (P<10-4) in 402 cases and 2,537 controls and confirmed an association between FMD and a variant in the phosphatase and actin regulator 1 gene (PHACTR1)...
October 2016: PLoS Genetics
https://www.readbyqxmd.com/read/27785697/inhibition-of-lipopolysaccharide-induced-interleukin-8-in-human-adenocarcinoma-cell-line-ht-29-by-spore-probiotics-b-coagulans-and-b-subtilis-natto
#12
Masoumeh Azimirad, Masoud Alebouyeh, Tahereh Naji
Probiotics are used as a treatment for different intestinal disorders. They confer health benefits by different ways. This study was aimed to investigate immunomodulatory effect of Bacillus probiotic spores on the production of lipopolysaccharide (LPS)-induced interleukin 8 (IL-8) in HT-29 intestinal epithelial cells. Differentiated intestinal epithelial cell line was used as a model for the study of colonization of purified spores (Bacillus subtilis (natto) and B. coagulans) and their anti-inflammatory effects...
October 26, 2016: Probiotics and Antimicrobial Proteins
https://www.readbyqxmd.com/read/27780089/the-relationship-between-mthfr-c677t-gene-polymorphism-and-essential-hypertension-in-a-sample-of-an-algerian-population-of-oran-city
#13
Asma Amrani-Midoun, Soto Romuald Kiando, Cyrielle Treard, Xavier Jeunemaitre, Nabila Bouatia-Naji
BACKGROUND: Many studies have investigated the role of 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism in essential hypertension (EH), but with conflicting results. AIM: To determine the eventual association between 5,10-methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism and hypertension in a sample of Algerian population from the Oran city. METHODS: A case-control study has been performed in 154 subjects including 82 hypertensives defined as subjects with elevated systolic blood pressure SBD≥140mmHg and or sustained diastolic blood pressure DBP≥90mmHg, and 72 normotensive subjects...
October 11, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27778639/hyperinsulinemia-and-insulin-resistance-in-dopamine-%C3%AE-hydroxylase-deficiency
#14
Amy C Arnold, Emily M Garland, Jorge E Celedonio, Satish R Raj, Naji N Abumrad, Italo Biaggioni, David Robertson, James M Luther, Cyndya A Shibao
CONTEXT: Dopamine β-hydroxylase (DBH) deficiency is a rare genetic disorder characterized by failure to convert dopamine into norepinephrine. These patients have absence of sympathetic adrenergic function, predisposing to orthostatic hypotension. DBH deficient mice exhibit hyperinsulinemia, lower plasma glucose levels, and insulin resistance due to loss of tonic sympathetic inhibition of insulin secretion. The impact of DBH deficiency on glucose homeostasis in humans is unknown. CASE DESCRIPTION: We describe the metabolic profile of an adolescent female DBH deficient patient...
October 25, 2016: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27761560/tall-cell-variant-papillary-thyroid-carcinoma-in-saudi-patients-a-clinicopathological-and-outcomes-analysis
#15
Khalid H Al-Qahtani, Mutahir A Tunio, Mushabbab Al Asiri, Yasser Bayoumi, Walaa A Alshehri, Naji J Aljohani, Ahmed Amir Ali, Hanadi Fatani
To evaluate the clinicopathological features and treatment outcomes of papillary thyroid carcinoma tall cell variant (PTC-TCV) in Saudi population. Methods: This retrospective study were medical records of 776 treated PTC patients between December 2007 and 2015, at King Fahad Medical City and King Khalid University Hospital, Riyadh, Kingdom of Saudi Arabia was probed for PTC-TCV. Total 42 (5.4%) patients were found to have PTC-TCV, which were investigated for demographic, symptoms, histopathological features, and treatment outcomes locoregional control (LRC), distant metastasis control (DMC), disease free survival (DFS), and overall survival (OS) rates...
November 2016: Saudi Medical Journal
https://www.readbyqxmd.com/read/27754927/prediagnostic-body-mass-index-trajectories-in-relation-to-prostate-cancer-incidence-and-mortality-in-the-plco-cancer-screening-trial
#16
Scott P Kelly, Barry I Graubard, Gabriella Andreotti, Naji Younes, Sean D Cleary, Michael B Cook
BACKGROUND: Evidence suggests that obesity in adulthood is associated with increased risk of "clinically significant" prostate cancer. However, studies of body mass index (BMI) across the adult life course and prostate cancer risks remain limited. METHODS: In a prospective cohort of 69 873 men in the Prostate, Lung, Colorectal and Ovarian Cancer Screening Trial, we examined associations of prediagnostic BMI across the adult life course with risk of incident prostate cancer and fatal prostate cancer (prostate cancer-specific mortality)...
March 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/27734519/a-hybrid-multibreath-wash-in-wash-out-lung-function-quantification-scheme-in-human-subjects-using-hyperpolarized-3-he-mri-for-simultaneous-assessment-of-specific-ventilation-alveolar-oxygen-tension-oxygen-uptake-and-air-trapping
#17
Hooman Hamedani, Stephen Kadlecek, Yi Xin, Sarmad Siddiqui, Heather Gatens, Joseph Naji, Masaru Ishii, Maurizio Cereda, Milton Rossman, Rahim Rizi
PURPOSE: To present a method for simultaneous acquisition of alveolar oxygen tension (PA O2 ), specific ventilation (SV), and apparent diffusion coefficient (ADC) of hyperpolarized (HP) gas in the human lung, allowing reinterpretation of the PA O2 and SV maps to produce a map of oxygen uptake (R). METHOD: An imaging scheme was designed with a series of identical normoxic HP gas wash-in breaths to measure ADC, SV, PA O2 , and R in less than 2 min. Signal dynamics were fit to an iterative recursive model that regionally solved for these parameters...
October 13, 2016: Magnetic Resonance in Medicine: Official Journal of the Society of Magnetic Resonance in Medicine
https://www.readbyqxmd.com/read/27732837/single-cell-mass-cytometry-analysis-of-the-human-endocrine-pancreas
#18
Yue J Wang, Maria L Golson, Jonathan Schug, Daniel Traum, Chengyang Liu, Kumar Vivek, Craig Dorrell, Ali Naji, Alvin C Powers, Kyong-Mi Chang, Markus Grompe, Klaus H Kaestner
The human endocrine pancreas consists of multiple cell types and plays a critical role in glucose homeostasis. Here, we apply mass cytometry technology to measure all major islet hormones, proliferative markers, and readouts of signaling pathways involved in proliferation at single-cell resolution. Using this innovative technology, we simultaneously examined baseline proliferation levels of all endocrine cell types from birth through adulthood, as well as in response to the mitogen harmine. High-dimensional analysis of our marker protein expression revealed three major clusters of beta cells within individuals...
October 11, 2016: Cell Metabolism
https://www.readbyqxmd.com/read/27729547/rationale-for-determining-the-functional-potency-of-mesenchymal-stem-cells-in-preventing-regulated-cell-death-for-therapeutic-use
#19
Abderrahim Naji, Narufumi Suganuma, Nicolas Espagnolle, Ken-Ichi Yagyu, Nobuyasu Baba, Luc Sensebé, Frédéric Deschaseaux
: : Mesenchymal stem (stromal) cells (MSCs) are being investigated for treating degenerative and inflammatory disorders because of their reparative and immunomodulatory properties. Intricate mechanisms relate cell death processes with immune responses, which have implications for degenerative and inflammatory conditions. We review the therapeutic value of MSCs in terms of preventing regulated cell death (RCD). When cells identify an insult, specific intracellular pathways are elicited for execution of RCD processes, such as apoptosis, necroptosis, and pyroptosis...
October 11, 2016: Stem Cells Translational Medicine
https://www.readbyqxmd.com/read/27725283/chitosanase-purified-from-bacterial-isolate-bacillus-licheniformis-of-ruined-vegetables-displays-broad-spectrum-biofilm-inhibition
#20
Sahira Nsayef Muslim, Israa M S Al-Kadmy, Nadheema Hammood Hussein, Alaa Naseer Mohammed Ali, Buthainah Mohammed Taha, Sarah Naji Aziz, Abdulaziz Abdullah Al Kheraif, Darshan Devang Divakar, Ravikumar Ramakrishnaiah
A number of bacterial species produces chitosanases which has variety of applications because of its high biodegradability, non-toxicity and antimicrobial assets. In the present study chitosanase is purified from new bacterial species Bacillus licheniformis from spoiled vegetable. This novel strain of Bacillus licheniformis isolated from spoilt cucumber and pepper samples has the ability to produce the chitosanase enzyme when grown on chitosan substrate. Study also examined its antibiofilm properties against diverse bacterial species with biofilm forming ability...
October 8, 2016: Microbial Pathogenesis
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