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https://www.readbyqxmd.com/read/29319485/attitudes-of-graduating-canadian-urology-residents-on-the-job-market-is-it-getting-better-or-are-we-just-spinning-our-wheels
#1
Gregory William Hosier, Naji Touma
INTRODUCTION: There has been increasing awareness of employment difficulties for physicians, especially surgeons, in Canada over the past few years. Our objective was to elucidate the attitudes and experiences of graduating Canadian urology residents in obtaining employment. METHODS: We surveyed four separate cohorts of graduating urology residents in 2010, 2011, 2016, and 2017. Responses from the 2010 and 2011 cohorts were combined and compared to the combined results of the 2016 and 2017 cohorts...
December 22, 2017: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
https://www.readbyqxmd.com/read/29289435/reverse-takotsubo-cardiomyopathy-during-general-anesthesia-in-a-16-year-old-female-victim-of-war
#2
Amro Khalili, Alia Dabbous, Samar Taha, Sara Naji, Samar Bahjah, Jean Beresian
No abstract text is available yet for this article.
November 16, 2017: Journal of Cardiothoracic and Vascular Anesthesia
https://www.readbyqxmd.com/read/29288545/a-randomized-trial-of-lorcaserin-and-lifestyle-counseling-for-maintaining-weight-loss-achieved-with-a-low-calorie-diet
#3
Jena Shaw Tronieri, Thomas A Wadden, Robert I Berkowitz, Ariana M Chao, Rebecca L Pearl, Naji Alamuddin, Sharon M Leonard, Ray Carvajal, Zayna M Bakizada, Emilie Pinkasavage, Kathryn A Gruber, Olivia A Walsh, Nasreen Alfaris
OBJECTIVE: Improving the maintenance of lost weight remains a critical challenge, which can be addressed by long-term behavioral and/or pharmacological interventions. METHODS: This study investigated the efficacy of combined behavioral and pharmacological treatment in facilitating weight loss maintenance (WLM) in 137 adults (86.1% female; 68.6% black; BMI = 37.0 ± 5.6 kg/m2 ) who had lost ≥ 5% of initial weight during a 14-week low-calorie diet (LCD) program (mean = 9...
December 29, 2017: Obesity
https://www.readbyqxmd.com/read/29276957/microplastics-contamination-in-molluscs-from-the-northern-part-of-the-persian-gulf
#4
Abolfazl Naji, Marzieh Nuri, A Dick Vethaak
Microplastics (MPs) are well-known emerging contaminants in the marine environment. A key route by which MPs can directly affect marine life is through ingestion. The objective of the present study was to evaluate the occurrence of MPs in marine life and seafood for human consumption in the Persian Gulf. We conducted a whole body analysis of MP (between 10 and 5000 μm in diameter) abundance in five species of molluscs with different feeding strategies, including both gastropods and bivalves from the littoral zone of the Iranian coast of the Persian Gulf...
December 22, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/29275308/early-pet-ct-after-stereotactic-radiotherapy-for-stage-1-non-small-cell-lung-carcinoma-is-predictive-of-local-control
#5
Marguerite Tyran, Nathalie Charrier, Julien Darreon, Anne Madroszyk, Agnes Tallet, Naji Salem
BACKGROUND/AIM: Radiological evaluation after stereotactic-body-radiotherapy (SBRT) for non-small-cell lung carcinoma (NSCLC) is often difficult due to lung radiation-induced image modifications on computed tomographic (CT) scan. The aim of this study was to evaluate positron-emission tomography-computed tomography (PET-CT) using fluorodeoxyglucose after SBRT in primary lung cancer. PATIENTS AND METHODS: Eighteen patients with histologically proven NSCLC were treated with SBRT...
January 2018: In Vivo
https://www.readbyqxmd.com/read/29262326/hiv-specific-cd8-t-cells-exhibit-reduced-and-differentially-regulated-cytolytic-activity-in-lymphoid-tissue
#6
Morgan A Reuter, Perla M Del Rio Estrada, Marcus Buggert, Constantinos Petrovas, Sara Ferrando-Martinez, Son Nguyen, Alberto Sada Japp, Yuria Ablanedo-Terrazas, Amaranta Rivero-Arrieta, Leticia Kuri-Cervantes, Heidi M Gunzelman, Emma Gostick, David A Price, Richard A Koup, Ali Naji, David H Canaday, Gustavo Reyes-Terán, Michael R Betts
Elimination of lymphoid tissue reservoirs is a key component of HIV eradication strategies. CD8+ T cells play a critical role in control of HIV, but their functional attributes in lymph nodes (LNs) remain unclear. Here, we show that memory, follicular CXCR5+, and HIV-specific CD8+ T cells from LNs do not manifest the properties of cytolytic CD8+ T cells. While the frequency of follicular CXCR5+ CD8+ T cells was strongly inversely associated with peripheral viremia, this association was not dependent on cytolytic CXCR5+ CD8+ T cells...
December 19, 2017: Cell Reports
https://www.readbyqxmd.com/read/29247784/efficacy-of-vitamin-d-interventional-strategies-in-saudi-children-and-adults
#7
REVIEW
Nasser M Al-Daghri, Sherif H Abd-Alrahman, Amaresh Panigrahy, Yousef Al-Saleh, Naji Aljohani, Omar S Al-Attas, Majed Alokail, Malak N K Khattak
Despite the amount of sunshine in Saudi Arabia, vitamin D (25(OH)D) deficiency is highly prevalent among Saudis. Several strategies are known to improve 25(OH)D status. The aim of this study was to evaluate the efficacy of different interventional strategies in improving 25(OH)D status in Saudi children and adults. This interventional study was undertaken among 593 out of 1152 Saudi subjects [530 students (aged 13-17 years) and 63 teachers (aged 26-46 years)] over a 6-month period from different secondary schools in Riyadh, Saudi Arabia...
December 13, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29247783/sex-specific-expression-of-apolipoprotein-levels-following-replenishment-of-vitamin-d
#8
REVIEW
Nasser M Al-Daghri, Kaiser Wani, Shaun Sabico, Spiro D Garbis, George P Chrousos, Osama E Amer, Mohammed Ghouse Ahmed Ansari, Yousef Al-Saleh, Naji J Aljohani, Omar S Al-Attas, Majed S Alokail
Numerous studies have been done to establish the relationship between vitamin D and lipids, yet a definitive causal link is not found. This interventional study aims to evaluate and compare levels of apolipoproteins among vitamin D deficient subjects at baseline and after they achieved full vitamin D status correction.120 Saudi adults with vitamin D deficiency [25(OH)D < 50nmol/l] were recruited and given 50,000IU cholecalciferol weekly for first 2 months, then twice a month for next 2 months, followed by daily 1000IU until month 6...
December 13, 2017: Journal of Steroid Biochemistry and Molecular Biology
https://www.readbyqxmd.com/read/29220533/androgens-irregular-menses-and-risk-of-diabetes-and-coronary-artery-calcification-in-the-diabetes-prevention-program
#9
Catherine Kim, Vanita R Aroda, Ronald B Goldberg, Naji Younes, Sharon L Edelstein, MaryLou Carrion-Petersen, David A Ehrmann
Context: It is unclear whether relative elevations in androgens or irregular menses (IM) are associated with greater cardiometabolic risk among women who are already overweight and glucose intolerant. Research Design and Methods: We conducted a secondary analysis of Diabetes Prevention Program (DPP) and the DPP Outcomes Study (DPPOS). Participants included women with sex hormone measurements who did not use exogenous estrogen (n=1422). We examined whether free androgen index (FAI) or IM were associated with diabetes risk during the DPP/DPPOS or with coronary artery calcification (CAC) at DPPOS year 10...
December 6, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29209810/a-comparison-of-the-meltpro%C3%A2-hpv-test-with-the-cobas%C3%A2-hpv-test-for-detecting-and-genotyping-14-high-risk-human-papillomavirus-types
#10
Zhiteng Tang, Ye Xu, Najie Song, Dongqing Zou, Yiqun Liao, Qingge Li, Chao Pan
The clinical performance of the newly developed MeltPro® HPV Test, based on multicolor melting curve analysis, was evaluated and compared with the commercially available Cobas® HPV Test for detection of HPV and genotyping of HPV-16 and HPV-18. A total of 1647 cervical samples were analyzed with both tests. The agreement values were 96.2% for HPV detection, 99.6% for HPV-16 identification, and 99.7% for HPV-18 identification. All genotyping results from MeltPro® HPV Test showed that HPV-52, HPV-58, and HPV-16 were the most common types in this study...
December 5, 2017: Archives of Virology
https://www.readbyqxmd.com/read/29202452/systemic-inflammation-is-associated-with-exaggerated-skeletal-muscle-protein-catabolism-in-maintenance-hemodialysis-patients
#11
Serpil M Deger, Adriana M Hung, Jorge L Gamboa, Edward D Siew, Charles D Ellis, Cindy Booker, Feng Sha, Haiming Li, Aihua Bian, Thomas G Stewart, Roy Zent, William E Mitch, Naji N Abumrad, T Alp Ikizler
BACKGROUND: Systemic inflammation and muscle wasting are highly prevalent and coexist in patients on maintenance hemodialysis (MHD). We aimed to determine the effects of systemic inflammation on skeletal muscle protein metabolism in MHD patients. METHODS: Whole body and skeletal muscle protein turnover were assessed by stable isotope kinetic studies. We incorporated expressions of E1, E214K, E3αI, E3αII, MuRF-1, and atrogin-1 in skeletal muscle tissue from integrin β1 gene KO CKD mice models...
November 16, 2017: JCI Insight
https://www.readbyqxmd.com/read/29190340/continuous-glucose-monitoring-for-hypoglycemia-avoidance-and-glucose-counterregulation-in-long-standing-type-1-diabetes
#12
Michael R Rickels, Amy J Peleckis, Cornelia Dalton-Bakes, Joseph R Naji, Nina A Ran, Huong-Lan Nguyen, Shannon O'Brien, Sanjian Chen, Insup Lee, Mark H Schutta
Context: Patients with long standing type 1 diabetes (T1D) are at increased risk for severe hypoglycemia due to defects in glucose counterregulation and hypoglycemia symptom recognition, in part mediated through exposure to hypoglycemia. Objective: To determine whether implementation of real-time continuous glucose monitoring (CGM) as a strategy for hypoglycemia avoidance could improve glucose counterregulation in patients with long standing T1D complicated by hypoglycemia unawareness...
November 28, 2017: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29184839/correlation-of-perceived-self-rated-oral-health-status-with-various-dental-health-and-awareness-factors
#13
Sunil Babu Kotha, Maham Chaudhary, Shayma Terkawi, Maram Ahmed, Shroog Naji Ghabban, Rohit Ashok Antony Fernandez
Aims and Objectives: Self-rated oral health is the key element that has a greater effect on quality of life and found to be authentic and logical to consider this as an indicator for overall oral health status. The aim was to investigate and identify the impact of various social and clinical factors on the perceived self-rated oral health status (PSR-OHS). Materials and Methods: A self-administered questionnaire was distributed 600 patients seeking information for age, gender, nationality, educational level, and their last dental visit followed by 15 questions related to social factors (patient self-rated oral health, patient-dentist communication, literacy level of the patient, and dental neglect) followed by estimating the clinical oral health status (decayed, missing, and filled teeth [DMFT] scores as per WHO norms)...
October 2017: Journal of International Society of Preventive & Community Dentistry
https://www.readbyqxmd.com/read/29172688/effect-of-nanoparticle-treatment-on-expression-of-a-key-gene-involved-in-thymoquinone-biosynthetic-pathway-in-nigella-sativa-l
#14
Mir Mohammad Hassan Kahila, Amin Mahdi Najy, Mahdi Rahaie, Mohammad Mir-Derikvand
Thymoquinone is the most important secondary metabolite in black Cumin, which has several pharmaceutical applications. In this study, effect of TiO2 and SiO2 nanoparticles as new elicitors, on expression of Geranyl diphosphate synthase gene (GPPS gene), as a key gene involved in thymoquione biosynthesis pathway was investigated in two Iranian accessions. Plants were treatment in the early flowering stage and after 24 h of 50 and 100 mg/L of each nanoparticle, separately. After RNA extraction, GPPS gene expression was analysed by qRT-PCR method...
November 27, 2017: Natural Product Research
https://www.readbyqxmd.com/read/29166111/effective-interactions-between-inclusions-in-an-active-bath
#15
Mahdi Zaeifi Yamchi, Ali Naji
We study effective two- and three-body interactions between non-active colloidal inclusions in an active bath of chiral or non-chiral particles, using Brownian dynamics simulations within a standard, two-dimensional model of disk-shaped inclusions and active particles. In a non-chiral active bath, we first corroborate previous findings on effective two-body repulsion mediated between the inclusions by elucidating the detailed non-monotonic features of the two-body force profiles, including a primary maximum and a secondary hump at larger separations that was not previously reported...
November 21, 2017: Journal of Chemical Physics
https://www.readbyqxmd.com/read/29163736/association-of-glycosylated-hemoglobin-levels-with-vitamin-d-status
#16
Badurudeen Mahmood Buhary, Ohoud Almohareb, Naji Aljohani, Saleh Alrajhi, Samer Elkaissi, Suphia Sherbeeni, Abdulrahman Almaghamsi, Shawana Abdulhamid Khan, Mussa H Almalki
Background: The discovery of vitamin D is one of medicine's great achievements. Despite all the positive evidence emerging about the beneficial effect of vitamin D, we still find many are vitamin D deficient. The purposes of this study were to examine the association between serum 25-hydroxyvitamin D (25(OH)D) and glycosylated hemoglobin (HbA1c) levels, to test the hypothesis that lower 25(OH)D levels are associated with poorer glucose control in diabetes mellitus (DM) patients and to investigate the effect of vitamin D supplementation on HbA1c levels...
December 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29158292/sphingomyelin-metabolism-is-a-regulator-of-kras-function
#17
Dharini van der Hoeven, Kwang-Jin Cho, Yong Zhou, Xiaoping Ma, Wei Chen, Ali Naji, Dina Montufar-Solis, Yan Zuo, Sarah E Kovar, Kandice R Levental, Jeffrey A Frost, Ransome van der Hoeven, John F Hancock
KRAS must localize to the plasma membrane (PM) for biological activity. We show here that multiple acid sphingomyelinase (ASM) inhibitors, including tricyclic antidepressants, mislocalized phosphatidylserine (PtdSer) and KRASG12V from the PM; resulting in abrogation of KRASG12V signaling and potent, selective growth inhibition of mutant KRAS transformed cancer cells. Concordantly, in nude mice, the ASM inhibitor fendiline decreased the rate of growth of oncogenic KRAS-expressing MiaPaCa-2 tumors, but had no effect on the growth of the wild-type KRAS-expressing BxPC-3 tumors...
November 20, 2017: Molecular and Cellular Biology
https://www.readbyqxmd.com/read/29149652/estimation-of-stature-from-hand-and-handprint-measurements-in-iban-population-in-sarawak-malaysia-and-its-applications-in-forensic-investigation
#18
Nuranis-Raihan Zulkifly, Roswanira Abd Wahab, Elizabeth Layang, Dzulkiflee Ismail, Wan Nur Syuhaila Mat Desa, Salina Hisham, Naji A Mahat
Handprints and dismembered hands are commonly found during crime scene investigations and disaster victim identifications, respectively. It has been indicated that the accuracy of handprint and hand measurements for estimating stature maybe population specific. Since Iban is the largest ethnic population in Sarawak, Malaysia and because the application of anthropometry of hand and handprint within this population as well as other populations within the Southeast Asian countries remain unreported, this present study that investigated the reliability and accuracy of these two anthropometric aspects acquires forensic significance...
October 31, 2017: Journal of Forensic and Legal Medicine
https://www.readbyqxmd.com/read/29116087/differential-expression-of-mir-93-and-mir-21-in-granulosa-cells-and-follicular-fluid-of-polycystic-ovary-syndrome-associating-with-different-phenotypes
#19
Mohammad Naji, Ashraf Aleyasin, Saeid Nekoonam, Ehsan Arefian, Reza Mahdian, Fardin Amidi
The heterogeneous and multifactorial essence of polycystic ovary syndrome (PCOS) renders a remarkable significance to microRNAs (miRNAs). Normo-androgenic (NA) and hyperandrogenic (HA) PCOS patients were compared with matched healthy women. Expression of miRNAs and TGFβ signaling genes was studied by qRT-PCR and western blotting. Effect of androgen on expression of miR-93 and miR-21 and involvement of androgen receptor were appraised. In granulosa cells (GCs), miR-93 and miR-21 showed significantly increased levels in HA patients compared to NA patients...
November 7, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29114352/bone-allograft-an-option-for-total-mandibular-reconstruction
#20
Masoud Fallahi Motlagh, Mohamad Bayat, Siamak Naji
Total mandibular reconstruction is one of the most challenging modalities in maxillofacial surgery. In this article, we try to introduce a method of total mandible reconstruction. We report a 25-year-old male patient with complete involvement of the mandible by Langerhans cell tumor. The patient underwent total mandibulectomy and reconstruction with bone allograft harvested from a donor who had died the day before. The patient has good functional and aesthetic results in a long time. It seems that bone allograft can be a good alternative to other methods in total mandibular reconstruction...
December 2017: Craniomaxillofacial Trauma & Reconstruction
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