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https://www.readbyqxmd.com/read/28218056/regulation-of-the-escherichia-coli-ydhy-t-operon-in-the-presence-of-alternative-electron-acceptors
#1
Naji Al Ibrahim, Jeffrey Green
The Escherichia coli K-12 ydhY-T operon, coding for a predicted oxidoreductase complex, is activated under anaerobic conditions and repressed in the presence of nitrate or nitrite. Anaerobic activation is mediated by the transcription factor FNR and nitrate/nitrite repression is mediated by NarXL and NarQP. In vitro transcription reactions revealed that the DNA upstream of ydhY-T contains sufficient information for RNA polymerase alone to initiate transcription from five locations. FNR severely inhibited synthesis of two of these transcripts (located upstream of, and within, the FNR binding site) and activated the FNR-dependent promoter previously identified in vivo...
February 3, 2017: Microbiology
https://www.readbyqxmd.com/read/28217264/eight-essential-foods-in-iranian-traditional-medicine-and-their-role-in-health-promotion-and-well-being
#2
REVIEW
Mehrdad Zeinalian, Mehdi Eshaghi, Mahdi Hadian, Homayoun Naji, Sayed Mohammad Masoud Marandi, Sedigheh Asgary
Eight essential foods (EEF) described in Iranian traditional medicine (ITM) have a determinant role to balance human temperament insuring health and well-being. EEF included oral, imaginary, auditory, visual, olfactory, touch, sexual, and familiarity food. Oral foods should be halal, compatible with individual temper, consumed up twice a day, and compatible with different seasons and geographic conditions. Imaginary food consists of the individual thought content which is directly related to mental and physical fitness...
2017: International Journal of Preventive Medicine
https://www.readbyqxmd.com/read/28181534/genomic-variant-in-il-37-confers-a-significant-risk-of-coronary-artery-disease
#3
Dan Yin, Duraid Hamied Naji, Yunlong Xia, Sisi Li, Ying Bai, Guiqing Jiang, Yuanyuan Zhao, Xiaojing Wang, Yufeng Huang, Shanshan Chen, Jingjing Fa, Chengcheng Tan, Mengchen Zhou, Yingchao Zhou, Longfei Wang, Ying Liu, Feifei Chen, Jingqiu Liu, Qiuyun Chen, Xin Tu, Chengqi Xu, Qing K Wang
The interleukin 1 family plays an important role in the immune and inflammatory responses. Coronary artery disease (CAD) is a chronic inflammatory disease. However, the genetic association between IL-37, the seventh member of the IL-1 family, and CAD is unknown. Here we show that a single nucleotide polymorphism in the IL-37 gene (rs3811047) confers a significant risk of CAD. We have performed an association analysis between rs3811047 and CAD in two independent populations with 2,501 patients and 3,116 controls from China...
February 9, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28179619/rituximab-can-induce-remission-in-a-patient-with-ankylosing-spondylitis-who-failed-anti-tnf-%C3%AE-agent
#4
Fahmi AlDhaheri, Talal Almteri, Naji Dwid, Ahd Majdali, Nahed Janoudi, Hani Almoallim
BACKGROUND Ankylosing spondylitis (AS) is a chronic inflammatory disease that predominantly affects the axial skeleton. The ability of anti-TNF-α agents to reduce disease activity in patients with axial spondyloarthritis (axSpA), including AS, has been demonstrated in multiple randomized trials and several meta-analyses. Reports on the efficacy of rituximab in treatment of AS have described good results. We report on a patient with AS who failed anti-TNF-α therapy but showed good clinical improvement with rituximab therapy...
February 9, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28170374/corrigendum-analysis-of-self-antigen-specificity-of-islet-infiltrating-t-cells-from-human-donors-with-type-1-diabetes
#5
Jenny Aurielle B Babon, Megan E DeNicola, David M Blodgett, Inne Crèvecoeur, Thomas S Buttrick, René Maehr, Rita Bottino, Ali Naji, John Kaddis, Wassim Elyaman, Eddie A James, Rachana Haliyur, Marcela Brissova, Lut Overbergh, Chantal Mathieu, Thomas Delong, Kathryn Haskins, Alberto Pugliese, Martha Campbell-Thompson, Clayton Mathews, Mark A Atkinson, Alvin C Powers, David M Harlan, Sally C Kent
No abstract text is available yet for this article.
February 7, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28165382/real-time-apnoea-monitoring-of-children-using-the-microsoft-kinect-sensor-a-pilot-study
#6
Ali Al-Naji, Kim Gibson, Sang-Heon Lee, Javaan Chahl
The objective of this study was to design a non-invasive system for the observation of respiratory rates and detection of apnoea using analysis of real time image sequences captured in any given sleep position and under any light conditions (even in dark environments). A Microsoft Kinect sensor was used to visualize the variations in the thorax and abdomen from the respiratory rhythm. These variations were magnified, analyzed and detected at a distance of 2.5 m from the subject. A modified motion magnification system and frame subtraction technique were used to identify breathing movements by detecting rapid motion areas in the magnified frame sequences...
February 3, 2017: Sensors
https://www.readbyqxmd.com/read/28134088/evolving-spectrum-of-lrba-deficiency-associated-chronic-arthritis-is-there-a-causative-role-in-juvenile-idiopathic-arthritis
#7
Sulaiman M Al-Mayouf, Hamzah Naji, Khalid Alismail, Anas M Alazami, Farrukh Sheikh, Walter Conca, Hamoud Al-Mousa
Lipopolysaccharide-responsive, beige-like anchor protein (LRBA) deficiency causes common variable immunodeficiency (CVID) disorders and autoimmunity. LRBA deficiency has become a clinically variable syndrome with a wide spectrum of clinical manifestations. We report a patient with LRBA deficiency associated chronic non-erosive arthritis. This report highlights the spectrum of arthritis in such patients and the potential causative role of LRBA gene in juvenile arthritis.
January 27, 2017: Clinical and Experimental Rheumatology
https://www.readbyqxmd.com/read/28128435/vitamin-e-for-alzheimer-s-dementia-and-mild-cognitive-impairment
#8
REVIEW
Nicolas Farina, David Llewellyn, Mokhtar Gad El Kareem Nasr Isaac, Naji Tabet
BACKGROUND: Vitamin E occurs naturally in the diet. It has several biological activities, including functioning as an antioxidant to scavenge toxic free radicals. Evidence that free radicals may contribute to the pathological processes behind cognitive impairment has led to interest in the use of vitamin E supplements to treat mild cognitive impairment (MCI) and Alzheimer's disease (AD). This is an update of a Cochrane Review first published in 2000, and previously updated in 2006 and 2012...
January 27, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28126203/skin-derived-tslp-systemically-expands-regulatory-t-cells
#9
Theresa M Leichner, Atsushi Satake, Victor Sanoe Harrison, Yukinori Tanaka, Angela S Archambault, Brian S Kim, Mark C Siracusa, Warren J Leonard, Ali Naji, Gregory F Wu, David Artis, Taku Kambayashi
Regulatory T cells (Tregs) are a subset of CD4(+) T cells with suppressive function and are critical for limiting inappropriate activation of T cells. Hence, the expansion of Tregs is an attractive strategy for the treatment of autoimmune diseases. Here, we demonstrate that the skin possesses the remarkable capacity to systemically expand Treg numbers by producing thymic stromal lymphopoietin (TSLP) in response to vitamin D receptor stimulation. An ∼2-fold increase in the proportion and absolute number of Tregs was observed in mice treated topically but not systemically with the Vitamin D3 analog MC903...
January 23, 2017: Journal of Autoimmunity
https://www.readbyqxmd.com/read/28124502/association-between-weight-bias-internalization-and-metabolic-syndrome-among-treatment-seeking-individuals-with-obesity
#10
Rebecca L Pearl, Thomas A Wadden, Christina M Hopkins, Jena A Shaw, Matthew R Hayes, Zayna M Bakizada, Nasreen Alfaris, Ariana M Chao, Emilie Pinkasavage, Robert I Berkowitz, Naji Alamuddin
OBJECTIVE: Weight stigma is a chronic stressor that may increase cardiometabolic risk. Some individuals with obesity self-stigmatize (i.e., weight bias internalization, WBI). No study to date has examined whether WBI is associated with metabolic syndrome. METHODS: Blood pressure, waist circumference, and fasting glucose, triglycerides, and high-density lipoprotein cholesterol were measured at baseline in 178 adults with obesity enrolled in a weight-loss trial. Medication use for hypertension, dyslipidemia, and prediabetes was included in criteria for metabolic syndrome...
February 2017: Obesity
https://www.readbyqxmd.com/read/28121926/inflammation-as-a-contributing-factor-among-postmenopausal-saudi-women-with-osteoporosis
#11
Nasser M Al-Daghri, Ibrahim Aziz, Sobhy Yakout, Naji J Aljohani, Yousef Al-Saleh, Osama E Amer, Eman Sheshah, Ghaida Zakaria Younis, Fahad Badr M Al-Badr
Postmenopausal osteoporosis is an important metabolic bone disease characterized by rapid bone loss occurring in the postmenopausal period. Recently, the most prevalent form of clinically significant osteopenia and osteoporosis involves various inflammatory conditions. The aim of the study is to evaluate the association between proinflammatory markers (interleukin [IL]-1β, IL-6, TNF-α) with bone turnover markers (BTMs) in postmenopausal Saudi women with and without osteoporosis. A total of 200 postmenopausal Saudi women ≥50 years old, 100 with osteoporosis and 100 without osteoporosis (control) were recruited under the supervision of qualified physicians in King Salman Hospital and King Fahd Medical City, Riyadh, Saudi Arabia...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28121491/identification-of-macroscopic-sarcocysts-of-sarcocystis-cameli-from-one-humped-camel-camelus-dromedarius-in-iraq
#12
J P Dubey, N Naji, J Mowery, S Verma, R Calero-Bernal
There is considerable confusion concerning the identity of macroscopic Sarcocystis species in camels. Currently 2 species: Sarcocystis cameli, and Sarcocystis ippeni are recognized from 1-humped camel (Camelus dromedarius), and sarcocysts of both species are microscopic. Here, we report identity of macroscopic sarcocysts from the C. dromedarius in Iraq as Sarcocystis cameli. Five sarcocysts from the muscle of 2 adult camels collected in 1999 and stored in 10% formalin were studied by transmission electron microscopy (TEM)...
January 25, 2017: Journal of Parasitology
https://www.readbyqxmd.com/read/28104661/draft-genome-sequences-of-four-alkaliphilic-bacteria-belonging-to-the-anaerobacillus-genus
#13
Naji M Bassil, Jonathan R Lloyd
The draft genomes of the alkaliphilic, anaerobic bacteria, Anaerobacillus arseniciselenatis, A. alkalidiazotrophicus, and A. alkalilacustris, and a novel closely related isolate of the Anaerobacillus genus are reported here. These assembled genomes will help identify, at the molecular level, the phenotypic differences between the species of this poorly characterized genus.
January 19, 2017: Genome Announcements
https://www.readbyqxmd.com/read/28098427/emergence-of-mania-in-two-middle-aged-patients-with-a-history-of-unipolar-treatment-refractory-depression-receiving-vagus-nerve-stimulation
#14
Naji C Salloum, Marie C Walker, Sunil Gangwani, Charles R Conway
OBJECTIVES: We report on two patients who experienced emergence of full manic symptoms while receiving vagal nerve stimulation (VNS). METHODS: Two patients, both with a well-documented and verified history of longstanding unipolar depression, were initiated on VNS for treatment of their severe major depressive episodes. RESULTS: The two patients had emergence of full manic symptoms after 8 and 9 months of VNS, respectively. Manic symptoms were adequately managed with standard treatments (mood stabilizer and electroconvulsive therapy) and VNS was continued in the two subjects for up to 5 years without any further occurrences of manic/hypomanic episodes...
January 18, 2017: Bipolar Disorders
https://www.readbyqxmd.com/read/28069385/changes-of-renin-angiotensin-system-related-aminopeptidases-in-early-stage-alzheimer-s-disease
#15
Paul Richard Gard, Sara Fidalgo, Isabelle Lotter, Cassandra Richardson, Nicolas Farina, Jennifer Rusted, Naji Tabet
Activities of aminopeptidases A, B, and N (ApA, ApB & ApN) and insulin-regulated aminopeptidase (IRAP) have been seen to be decreased amongst patients with Alzheimer's disease (AD). All of these enzymes are involved with the brain renin-angiotensin system which is believed to be involved with learning and memory. This study aimed to explore the time course and the mechanisms underlying these changes. Serum samples were collected from 45 AD patients at the start of the study, and again 13months later (n=37)...
January 7, 2017: Experimental Gerontology
https://www.readbyqxmd.com/read/28060317/observation-and-quantification-of-mating-behavior-in-the-pinewood-nematode-bursaphelenchus-xylophilus
#16
Najie Zhu, Liqun Bai, Stefan Schütz, Baojun Liu, Zhenyu Liu, Xingyao Zhang, Hongshi Yu, Jiafu Hu
A method for observing and quantifying the mating behavior of the pinewood nematode, Bursaphelenchus xylophilus, was established under a stereomicroscope. To improve the mating efficiency of B. Xylophilus and to increase the chances of mating observation, virgin adults were cultured and used for the investigation. Eggs were obtained by keeping the nematodes in water and allowing the females to lay eggs for 10 min. The second-stage juveniles (J2) were synchronized by incubating the eggs for 24 h at 25 °C in the dark, and the early J4 were obtained by culturing the J2 with grey mold, Botrytis cinerea, for another 52 h...
December 25, 2016: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/28059047/the-elusive-nature-of-apoe-%C3%AE%C2%B54-in-mid-adulthood-understanding-the-cognitive-profile
#17
Claire Lancaster, Naji Tabet, Jennifer Rusted
OBJECTIVES: The apolipoprotein E (APOE) ε4 allele is an established risk factor for dementia, yet this genetic variant is associated with a mixed cognitive profile across the lifespan. This study undertakes both a systematic and meta-analytic review of research investigating APOE-related differences in cognition in mid-adulthood, when detrimental effects of the allele may first be detectable. METHODS: Thirty-six papers investigating the behavioral effects of APOE ε4 in mid-adulthood (defined as a mean sample age between 35 and 60 years) were reviewed...
January 6, 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28045690/clinical-case-of-the-month-a-49-year-old-man-who-presents-with-left-sided-weakness-an-update-on-ischemic-stroke
#18
Najy Masri, Rikki Weems, Falon Brown, Ben Andres, Fred Lopez
A 49 year-old man with a past medical history significant for essential hypertension, hyperlipidemia, and coronary artery disease status post percutaneous coronary intervention and stent placement in the right coronary artery in 2010 presented for evaluation of left hemiplegia. He was feeling well until three hours prior to presentation, at which time he fell while walking from his bedroom into the kitchen. After falling, he noticed that his left upper and lower extremities felt weak. He denied any symptoms preceding the fall or any loss of consciousness...
November 2016: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28039790/degradation-photocatalysis-of-tetrodotoxin-as-a-poison-by-gold-doped-pdo-nanoparticles-supported-on-reduced-graphene-oxide-nanocomposites-and-evaluation-of-its-antibacterial-activity
#19
Ali Fakhri, Mahsa Naji
In this project, synthesis of pure and gold doped PdO-reduced graphene oxide nanocomposites by sonochemical and deposition-precipitation process was performed and characterized using X-ray diffraction (XRD), transmission electronic microscopy (TEM) and X-ray photoelectron spectroscopy (XPS) and Raman spectroscopy. The specific surface area of synthesized un-doped and Au doped PdO-RGO nanocomposites is 83.2, 109.1m(2)g(-1) and total pore volume is 0.31, 0.40cm(3)g(-1), respectively. With Tetrodotoxin as a target pollutant, photocatalytic system of UV+photocatalyst+H2O2 was set up...
December 23, 2016: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28017199/effects-of-left-dlpfc-versus-right-ppc-tdcs-on-multiple-sclerosis-fatigue
#20
Moussa A Chalah, Naji Riachi, Rechdi Ahdab, Alaa Mhalla, Mohamed Abdellaoui, Alain Créange, Jean-Pascal Lefaucheur, Samar S Ayache
BACKGROUND AND OBJECTIVE: Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed to evaluate the effects of transcranial direct current stimulation (tDCS), a noninvasive brain stimulation technique, on such a challenging symptom. Our secondary outcomes included the assessment of tDCS impact on mood and attentional performance. METHODS: Ten fatigued MS patients were enrolled in a double-blind, sham-controlled, and cross-over study...
January 15, 2017: Journal of the Neurological Sciences
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