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Treatment of acute sinusitis

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https://www.readbyqxmd.com/read/29678716/surgical-management-of-medial-tentorial-meningioma-falcotentorial-and-torcular
#1
Andrea Talacchi, Antonio Biroli, Aurel Hasanbelliu, Francesca Locatelli
BACKGROUND: Falcotentorial meningiomas (FTM) stand out for their rarity, inconsistent definition, and surgical complexity. It is appropriate to deal with them in the context of medial tentorial meningiomas (MTM). METHODS: Clinical and radiological characteristics of MTM, comprising the typical features of FTM and tentorial meningioma (TM) along with surgical management, short- and long-term outcomes, are reported . RESULTS: FTM (n=16) were typically supratentorial, large, edematous tumors that caused mainly headache and hemianopia; TM (n=12) were infratentorial, smaller not edematous tumors that caused mainly headache and gait ataxia...
April 17, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29673431/the-aeromedical-management-of-allergic-rhinitis
#2
Nicole Powell-Dunford, Charles Reese, Alaistair Bushby, Berit H Munkeby, Sébastien Coste, Višnja Livajić Pezer, Lars Rosenkvist
INTRODUCTION: Allergic rhinitis is a prevalent condition warranting special aeromedical consideration due to its potential for acute and painful manifestations involving the middle ear or paranasal sinuses during rapid barometric pressure changes. Although second generation antihistamines and intranasal steroids are safe and effective treatments for this common condition, aeromedical management varies. METHODS: An aeromedical policy review of 14 public access civil and military data repositories was undertaken...
May 1, 2018: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29669783/vasoactive-intestinal-peptide-ameliorates-acute-myocarditis-and-atherosclerosis-by-regulating-inflammatory-and-autoimmune-responses
#3
Raquel Benitez, Virginia Delgado-Maroto, Marta Caro, Irene Forte-Lago, Mario Duran-Prado, Francisco O'Valle, Andrew H Lichtman, Elena Gonzalez-Rey, Mario Delgado
Vasoactive intestinal peptide (VIP) is a neuropeptide that exerts various vascular and cardioprotective functions and regulates immune function and inflammatory response at multiple levels. However, its role in inflammatory cardiovascular disorders is largely unknown. Myocarditis and atherosclerosis are two inflammatory and autoimmune cardiovascular diseases that cause important adverse circulatory events. In this study, we investigate the therapeutic effects of VIP in various well-established preclinical models of experimental autoimmune myocarditis and atherosclerosis...
April 18, 2018: Journal of Immunology: Official Journal of the American Association of Immunologists
https://www.readbyqxmd.com/read/29668894/endoscopic-treatment-of-ileal-pouch-sinus
#4
Nan Lan, Bo Shen
Background and aims: Pouch sinus is a serious complication in patients undergoing ileal pouch-anal anastomosis. The aim of this study was to verify the efficacy and safety of endoscopic needle knife sinusotomy (NKSi) in the management of pouch sinus. Methods: All consecutive patients with a pouch sinus treated with NKSi from 2008 to 2016 were identified. The primary outcomes were complete healing of the sinus and pouch survival. Results: A total of 109 patients were included...
April 12, 2018: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/29661787/thromboembolism-in-acute-lymphoblastic-leukemia-results-of-nopho-all2008-protocol-treatment-in-patients-1-45-years
#5
Cecilie Utke Rank, Nina Toft, Ruta Tuckuviene, Kathrine Grell, Ove Juul Nielsen, Thomas Leth Frandsen, Hanne Vibeke Hansen Marquart, Birgitte Klug Albertsen, Ulf Tedgård, Helene Hallböök, Ellen Ruud, Kirsten Brunsvig Jarvis, Petter Quist-Paulsen, Pasi Huttunen, Ulla Wartiovaara-Kautto, Ólafur Gísli Jónsson, Sonata Saulyte Trakymiene, Laimonas Griškevičius, Kadri Saks, Mari Punab, Kjeld Schmiegelow
Thromboembolism frequently occurs during acute lymphoblastic leukemia (ALL) therapy. We prospectively registered thromboembolic events during treatment of 1772 consecutive Nordic/Baltic ALL patients 1-45years treated according to the Nordic Society of Pediatric Hematology and Oncology (NOPHO) ALL2008 protocol (7/2008-4/2017). The 2.5-year cumulative incidence of thromboembolism (N=137) was 7.9% (95% confidence interval (CI) 6.6-9.1); higher in patients ≥10years ( P <.0001). Adjusted hazard ratios (HRa) were associated with greater age (10...
April 16, 2018: Blood
https://www.readbyqxmd.com/read/29643005/a-case-report-of-orbital-langerhans-cell-histiocytosis-presenting-as-a-orbital-cellulitis
#6
M Albert-Fort, M González-Candial
CLINICAL CASE: A 10-year-old girl was seen with a 3-week history of right upper lid swelling and with no other symptoms or fever. There was no recent history of sinusitis, trauma, or previous infection involving the periorbital area, or response to oral antibiotic treatment. Orbital computed tomography showed a lesion involving the upper margin of the orbit, and bone destruction at the orbital roof. Biopsy performed revealed the presence of Langerhans cell Histiocytosis. The lesion was surgically debulked and corticosteroids were used intra-operatively...
April 8, 2018: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/29626151/metabolomic-profiling-in-acute-st-segment-elevation-myocardial-infarction-identifies-succinate-as-an-early-marker-of-human-ischemia-reperfusion-injury
#7
Matthias Kohlhauer, Sam Dawkins, Ana S H Costa, Regent Lee, Timothy Young, Victoria R Pell, Robin P Choudhury, Adrian P Banning, Rajesh K Kharbanda, Kourosh Saeb-Parsy, Michael P Murphy, Christian Frezza, Thomas Krieg, Keith M Channon
BACKGROUND: Ischemia-reperfusion injury following ST-segment-elevation myocardial infarction (STEMI) is a leading determinant of clinical outcome. In experimental models of myocardial ischemia, succinate accumulation leading to mitochondrial dysfunction is a major cause of ischemia-reperfusion injury; however, the potential importance and specificity of myocardial succinate accumulation in human STEMI is unknown. We sought to identify the metabolites released from the heart in patients undergoing primary percutaneous coronary intervention for emergency treatment of STEMI...
April 6, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29623187/moxifloxacin-induced-tinnitus-in-an-older-adult
#8
Amber Onoh, Sunny A Linnebur, Danielle R Fixen
An increased risk of bacterial resistance toward fluoroquinolones and the increased risk of disabling and serious adverse effects prompted the US Food and Drug Administration to recommend limiting fluoroquinolone use to the treatment of community-acquired pneumonia, skin and skin-structure infections, bacterial sinusitis, plague, chronic bronchitis exacerbations, and complicated intra-abdominal infections. We report a case of moxifloxacin-induced tinnitus in an older adult prescribed oral moxifloxacin 400 mg for 5 days for the treatment of acute diverticulitis, due to allergies to nonfluoroquinolone preferred agents...
April 2018: Therapeutic Advances in Drug Safety
https://www.readbyqxmd.com/read/29610253/deconstructing-progression-from-pneumococcal-colonization-to-disease
#9
Stephen I Pelton
Despite advances in treatment and prevention, the pneumococcus continues as a dominant cause of severe pneumonia and sepsis, of otitis media, sinusitis and nonbacteremic pneumonia. Lewnard and colleagues use a unique data set of nasopharyngeal and middle ear fluid samples to provide further insight into the progression of nasopharyngeal pneumococcal colonization to disease. They report the comparative rate of progression from colonization to otitis media by serotype, providing insight as to how conjugate vaccines that do not reduce the overall presence of pneumococci in the nasopharynx dramatically impact the incidence of acute and complex otitis media...
April 2, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29602766/predictors-of-acute-failure-ablation-of-intra-atrial-re-entrant-tachycardia-in-patients-with-congenital-heart-disease-cardiac-disease-atypical-flutter-and-previous-atrial-fibrillation
#10
Ivo Roca-Luque, Nuria Rivas-Gándara, Laura Dos-Subirà, Jaume Francisco-Pascual, Antònia Pijuan-Domenech, Jordi Pérez-Rodon, Alba Santos-Ortega, Ferran Roses-Noguer, Ignacio Ferreira-Gonzalez, David García-Dorado García, Angel Moya Mitjans
BACKGROUND: Intra-atrial re-entrant tachycardia (IART) in patients with congenital heart disease (CHD) increases morbidity and mortality. Radiofrequency catheter ablation has evolved as the first-line treatment. The aim of this study was to analyze the acute success and to identify predictors of failed IART radiofrequency catheter ablation in CHD. METHODS AND RESULTS: The observational study included all consecutive patients with CHD who underwent a first ablation procedure for IART at a single center from January 2009 to December 2015 (94 patients, 39...
March 30, 2018: Journal of the American Heart Association
https://www.readbyqxmd.com/read/29574428/thyrotoxic-crisis-as-an-acute-clinical-presentation-in-a-child
#11
Adam Bonfield, Savitha Shenoy
A previously well, 4-year-old girl presented with a 4-6 weeks' history of increased appetite, weight loss, tiredness, sleep difficulty, excessive sweating, swelling in the neck and new-onset 'prominent, protruding eyes.' Family history revealed paternal grandmother receiving treatment for hyperthyroidism. Clinical assessment demonstrated features of thyrotoxicosis (tachycardia, warm peripheries, small smooth goitre with no nodules, exophthalmos). TFT (Free T4=101 pmol/L, thyroid-stimulating hormone <0...
March 23, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29563819/a-case-of-brucella-melitensis-endocarditis-in-a-patient-with-cardiovascular-implantable-electronic-device
#12
Wasl Al-Adsani, Ali Ahmad, Mohammad Al-Mousa
Background: Brucellosis is a bacterial infection, caused by the nonmotile gram-negative aerobic coccobacilli. The clinical manifestation of brucellosis is variable, ranging from mild disease to severe disease. The gold standard test to confirm the diagnosis of brucellosis is assaying blood, bone marrow, or other body fluids or by tissue culture. Preferred first-line treatment in adults with uncomplicated, nonlocalized disease consists of doxycycline-aminoglycoside combination. The recommended duration of treatment is 6 weeks...
2018: Infection and Drug Resistance
https://www.readbyqxmd.com/read/29541763/associations-of-obstructive-sleep-apnea-with-atrial-fibrillation-and-continuous-positive-airway-pressure-treatment-a-review
#13
Dominik Linz, R Doug McEvoy, Martin R Cowie, Virend K Somers, Stanley Nattel, Patrick Lévy, Jonathan M Kalman, Prashanthan Sanders
Importance: Obstructive sleep apnea (OSA) is the most common clinically significant breathing abnormality during sleep. It is highly prevalent among patients with atrial fibrillation (AF), and it promotes arrhythmogenesis and impairs treatment efficacy. Observations: The prevalence of OSA ranges from 3% to 49% in population-based studies and from 21% to 74% in patients with AF. Diagnosis and treatment of OSA in patients with AF requires a close interdisciplinary collaboration between electrophysiologists, cardiologists, and sleep specialists...
March 14, 2018: JAMA Cardiology
https://www.readbyqxmd.com/read/29534838/cortactin-expression-in-nasal-polyps-of-aspirin-exacerbated-respiratory-disease-aerd-patients
#14
Giuseppe Brescia, Daniela Parrino, Lorenzo Nicolè, Claudia Zanotti, Cristiano Lanza, Umberto Barion, Filippo Marino, Gino Marioni
PURPOSE: The term aspirin-exacerbated respiratory disease (AERD) refers to a combination of asthma, chronic rhinosinusitis with nasal polyposis (CRSwNP), and acute respiratory tract reactions to nonsteroidal anti-inflammatory drugs. AERD has now been included among the CRSwNP endotypes, and is considered one of the most aggressive in terms of disease recurrence. Cortactin is a multi-domain protein with a part in several cellular mechanisms involving actin assembly and cytoskeleton arrangement...
March 5, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29530427/the-association-between-otogenic-lateral-sinus-thrombosis-and-thrombophilia-a-long-term-follow-up
#15
Shay Schneider, Joseph Kapelushnik, Mordechai Kraus, Sabri El Saied, Itai Levi, Daniel Michael Kaplan
PURPOSE: Otogenic lateral sinus thrombosis (OLST) is an intracranial, potentially life-threatening complication of acute and chronic otitis media. Since congenital thrombophilic disorders are risk factors for cerebral venous thrombosis, OLST may be related to thrombophilia. The aim of our study was twofold: to evaluate whether patients who suffered from OLST in childhood also have thrombophilia, and whether these patients experienced thromboembolic episodes in future years. STUDY DESIGN: Retrospective case series...
March 7, 2018: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/29529705/video-assisted-subcutaneous-destruction-of-the-sinus-tract-with-vessel-loop-drainage-as-minimally-invasive-surgical-treatment-for-pilonidal-sinus-disease
#16
Michael Korenkov
The video-assisted subcutaneous destruction of the sinus tract (VADST) is a novel, minimally-invasive technique for the treatment of pilonidal sinus disease (PSD). This is an advancement of the previously described subcutaneous destruction of the sinus tract and the removal of hairs as well as the long-term vessel-loop drainage of the wound channel (DST). Although the first results of this operation seemed to be promising, some of my colleagues felt that the blind approach to this procedure could be its potential "weak point"...
March 12, 2018: Surgical Technology International
https://www.readbyqxmd.com/read/29519311/a-24-year-old-woman-with-precipitous-respiratory-failure-after-lung-transplantation
#17
Whittney A Warren, Domingo Franco-Palacios, Christopher S King, Oksana A Shlobin, Steven D Nathan, Shalika B Katugaha, Haresh Mani, A Whitney Brown
A 24-year-old woman with ΔF508/Y1092X cystic fibrosis (CF) complicated by severe obstructive lung disease (FEV1 of 30% predicted) was admitted for IV antibiotics for planned sinus surgery resulting from severe chronic sinusitis causing frequent exacerbations and declining lung function. She had persistent airway infection with multidrug-resistant Pseudomonas aeruginosa, methicillin-resistant Staphylococcus aureus, and growth of a fungus presumed to be an airway colonizer, identified as Stephanoascus ciferrii 1 year before presentation...
March 2018: Chest
https://www.readbyqxmd.com/read/29519133/effect-of-fentanyl-nasal-packing-treatment-on-patients-with-acute-postoperative-pain-after-nasal-operation-a-randomized-double-blind-controlled-trial
#18
Kwan-Sub Kim, Nam-Kyung Yeo, Seong-Su Kim, Woong-Sub Park, Su-Hyun Kwak, Sang-Hyeon Cho, Gyu-Wan Sung, Hae-Sook Kim, Sang-Wook Yi, Hae Jun Cho
PURPOSE: Nasal packing is an option for bleeding control after endoscopic sinus surgery and septoplasty. Although new packing materials have been developed, patients still suffer from pain and require additional analgesics treatments. In this study, a prospective, randomized, and double-blind controlled trial was designed to evaluate the effect of fentanyl-soaked packing on pain after endoscopic sinus surgery and septoplasty. METHODS: One hundred fifty-two patients who underwent nasal surgeries due to chronic rhinosinusitis or nasal septal deviation were enrolled in this study...
March 1, 2018: Annals of Otology, Rhinology, and Laryngology
https://www.readbyqxmd.com/read/29518134/digoxin-for-atrial-fibrillation-and-atrial-flutter-a-systematic-review-with-meta-analysis-and-trial-sequential-analysis-of-randomised-clinical-trials
#19
Naqash J Sethi, Emil E Nielsen, Sanam Safi, Joshua Feinberg, Christian Gluud, Janus C Jakobsen
BACKGROUND: During recent years, systematic reviews of observational studies have compared digoxin to no digoxin in patients with atrial fibrillation or atrial flutter, and the results of these reviews suggested that digoxin seems to increase the risk of all-cause mortality regardless of concomitant heart failure. Our objective was to assess the benefits and harms of digoxin for atrial fibrillation and atrial flutter based on randomized clinical trials. METHODS: We searched CENTRAL, MEDLINE, Embase, LILACS, SCI-Expanded, BIOSIS for eligible trials comparing digoxin versus placebo, no intervention, or other medical interventions in patients with atrial fibrillation or atrial flutter in October 2016...
2018: PloS One
https://www.readbyqxmd.com/read/29490408/nonmodal-clinical-decision-support-and-antimicrobial-restriction-effects-on-rates-of-fluoroquinolone-use-in-uncomplicated-infections
#20
Lundy R Gunn, Robert Tunney, Kimberly Kelly
BACKGROUND:  Medication alert overrides remain persistently high over the past decade, influenced by factors such as "alert fatigue" and lack of provider acceptance. OBJECTIVE:  We compared the aggregate rate of fluoroquinolone (FQ) prescribing for the treatment of acute sinusitis, acute bronchitis, and uncomplicated urinary tract infections (UTIs) in adult inpatients prior to (historical control group) and after (prospective intervention group) implementation of a program requiring indication when ordering FQ antibiotics in combination with a nonmodal best-practice alert regarding the latest U...
January 2018: Applied Clinical Informatics
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