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Red cell alloantibody

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https://www.readbyqxmd.com/read/29664201/rare-blood-donor-needed
#1
Richard R Gammon, Harold Alvarez, Nancy Benitez
BACKGROUND: Here, we describe a 14-year-old male with leukocyte adhesion deficiency type 2 who was transferred to a university hospital with anemia (hemoglobin 6 g/dL) and multiple singular abscesses refractory to antimicrobials. CASE REPORT: As leukocyte adhesion deficiency type 2 is associated with Bombay phenotype, the patient's red blood cells (RBCs) were tested with commercial anti-H lectin Ulex europaeus. An allogeneic adsorption with phenotype-matched cells was performed...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29664198/hemoglobin-a-clearance-in-children-with-sickle-cell-anemia-on-chronic-transfusion-therapy
#2
Marianne E M Yee, Cassandra D Josephson, Anne M Winkler, Jennifer Webb, Naomi L C Luban, Traci Leong, Sean R Stowell, John D Roback, Ross M Fasano
BACKGROUND: Chronic transfusion therapy for sickle cell anemia reduces disease complications by diluting sickle-erythrocytes with hemoglobin A (HbA)-containing erythrocytes and suppressing erythropoiesis. Minor antigen mismatches may result in alloimmunization, but it is unknown if antigen mismatches or recipient characteristics influence HbA clearance posttransfusion. STUDY DESIGN AND METHODS: Children with sickle cell anemia on chronic transfusion therapy were followed prospectively for 12 months...
April 17, 2018: Transfusion
https://www.readbyqxmd.com/read/29624682/abo-incompatibility-and-rhig-immunoprophylaxis-protect-against-non-d-alloimmunization-by-pregnancy
#3
Carolien Zwiers, Joke M Koelewijn, Lisa Vermij, Joost van Sambeeck, Dick Oepkes, Masja de Haas, C Ellen van der Schoot
BACKGROUND: Hemolytic disease of the fetus and newborn (HDFN) is caused by maternal antibodies against fetal red blood cell antigens, most often anti-D, -K, or -c. ABO incompatibility between mother and child and anti-D immunoprophylaxis (RhIG) are known to reduce the risk of D immunization and subsequent HDFN. However, no immunoprophylaxis has been developed to prevent non-D immunizations. STUDY DESIGN AND METHODS: We evaluated whether ABO incompatibility has a preventive effect on formation of non-D alloantibodies, by performing a case-control study including pregnant women with newly detected non-D antibodies, identified within a nationwide data set, immunized during their first pregnancy and/or delivery...
April 6, 2018: Transfusion
https://www.readbyqxmd.com/read/29608322/a-review-of-in-vitro-methods-to-predict-the-clinical-significance-of-red-blood-cell-alloantibodies
#4
Sandra J Nance
This review was derived from a presentation made on September 2, 2016, for the first Academy Day presented by the Working Party on Immunohematology at the International Society of Blood Transfusion (ISBT) Congress in Dubai. The focus of this review is on the clinical significance of alloimmunization in transfusion-specifically, the parameters that contribute to a clinically significant alloantibody. The areas of focus were as follows: Introduction, Technical Aspects, and Indications and Limitations. Each section contains a brief review of selected literature and experiential knowledge...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29608321/management-of-pregnancy-sensitized-with-anti-inb-with-monocyte-monolayer-assay-and-maternal-blood-donation
#5
Raj Shree, Kimberly K Ma, Lay S Er, Meghan Delaney
Maternal red blood cell (RBC) alloantibodies can cause hemolytic disease of the fetus and newborn (HDFN). Although much is described about common antibodies associated with HDFN, management of a pregnancy complicated by a maternal rare antibody presents several challenges related to assessment of fetal anemia risk, availability of blood for transfusion to the mother and/or the fetus or newborn if needed, and planning for delivery in the case of maternal hemorrhage. Here we report the laboratory medicine workup of a patient who presented for obstetrical care in the United States in the third trimester and had a rare antibody (anti-Inb)...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29608319/warm-autoadsorption-using-zzap
#6
Farai M Tsimba-Chitsva, Amy Caballero, Becky Svatora
The masking of clinically significant alloantibodies by warm autoantibodies presents challenges in pretransfusion testing. The adoption of transfusion practices such as the issuing of "least incompatible" red blood cells (RBCs) without a complete antibody workup is potentially unsafe for patients. Several autoadsorption methods can be used to remove autoantibody reactivity. ZZAP treatment of autologous RBCs is an efficient way to prepare the cells for autoadsorption. Autoadsorbed serum or plasma can then be used to remove autoantibody reactivity and identify clinically significant alloantibodies...
January 2018: Immunohematology
https://www.readbyqxmd.com/read/29593460/association-of-il-6-c-572g-gene-polymorphism-with-anti-e-production
#7
Jeong-Shi Lin, Li-Hsuan Lee, Hsueng-Mei Liu, Ying-Ju Chen, Tzeon-Jye Chiou
Background: Interleukin 6 (IL-6) is involved in regulation of immunoglobulin production. The aim of this study was to investigate the association between IL-6 single nucleotide polymorphisms (SNPs) in the IL-6 promoter and anti-E in red blood cell (RBC) transfusion recipients. Methods: 50 healthy subjects, 54 patients with RBC alloantibody anti-E (responders), and 45 patients without alloantibody (non-responders) were recruited. All patients were E antigen-negative...
January 2018: Transfusion Medicine and Hemotherapy
https://www.readbyqxmd.com/read/29563682/anti-kp-a-alloantibody-development-of-a-rare-alloantibody-in-a-non-hodgkin-s-lymphoma-patient-of-indian-origin
#8
Sadhana Mangwana, Vivek Gangwar
The Kell blood group system is complex, contains many antigens, highly immunogenic, and potent in triggering immune reactions. Antibodies to Kell blood group system are the most common immune red cell antibodies, following ABO and Rh. However, among the anti-Kell antibodies; anti-Kpa is extremely rare. We report an interesting case of Anti-Kpa in a 59-year-old female patient of Non-Hodgkin's Lymphoma, post radiotherapy, who first developed warm autoantibody and later developed anti-Kpa alloantibody on multiple transfusions...
January 2018: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/29563676/an-approach-to-incompatible-cross-matched-red-cells-our-experience-in-a-major-regional-blood-transfusion-center-at-kolkata-eastern-india
#9
Prasun Bhattacharya, Eeshita Samanta, Nowroz Afroza, Archana Naik, Rathindranath Biswas
INTRODUCTION: With the increased utilization of immunohematology (IH) analyzers in the transfusion medicine, type, and screen policy is the method of choice. Still, the importance of routine crossmatching could not be overruled. Here, we tried to understand the clinical conditions and safety of red cell transfusion and their outcomes. MATERIALS AND METHODS: This prospective study was conducted by IH laboratory, Medical College Kolkata, Blood Bank from October 1, 2015 to March 31, 2016...
January 2018: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/29563670/prevalence-of-irregular-red-cell-antibody-in-healthy-blood-donors-attending-a-tertiary-care-hospital-in-north-india
#10
Raj Nath Makroo, Saroj Rajput, Soma Agarwal, Mohit Chowdhry, Bindu Prakash, Prashant Karna
BACKGROUND: Alloantibodies may be detected in blood donors who have either been transfused previously or female donors with previous obstetric events. These antibodies can occasionally cause severe transfusion reaction, if a large amount of plasma or whole blood is transfused, as in massive transfusions and pediatric patients. AIMS: The present study aims to assess the prevalence of red cell antibodies in healthy blood donors at a tertiary care hospital-based blood bank in India...
January 2018: Asian Journal of Transfusion Science
https://www.readbyqxmd.com/read/29553439/red-blood-cell-alloantibodies-in-multiply-transfused-patients-in-the-occupied-palestinian-territory-a-pilot-study
#11
Ahmad Yaseen, Sa'd Suleiman, Omar Abu Zenah, Adham Abu Taha
BACKGROUND: Red blood-cell transfusion has greatly reduced the mortality and morbidity in multiply transfused patients with thalassaemia and sickle cell disease. However, this can result in red blood-cell isoimmunisation with autoantibodies and alloantibodies, which can lead to serious complications such as delayed haemolytic transfusion reaction. The aim of this study was to assess the frequency and types of alloantibodies in multiply transfused patients living in the north of the West Bank...
February 21, 2018: Lancet
https://www.readbyqxmd.com/read/29519368/transfusion-management-for-patients-taking-an-anti-cd38-monoclonal-antibody
#12
Carolina Bonet Bub, Isabel Nagle Dos Reis, Maria Giselda Aravechia, Leandro Dinalli Santos, Eduardo Peres Bastos, José Mauro Kutner, Lilian Castilho
INTRODUCTION: Pre-transfusion tests, essential for the release of blood components, may be affected by drugs. Monoclonal antibodies represent a class of medications increasingly used in the clinical practice, with anti-CD38 monoclonal antibodies (daratumumab) being a promising resource in the treatment of refractory myeloma. This monoclonal antibody recognizes CD38 in myeloma cells and interferes with pre-transfusion tests by causing panreactivity in indirect antiglobulin tests thereby clinically masking alloantibodies...
January 2018: Revista Brasileira de Hematologia e Hemoterapia
https://www.readbyqxmd.com/read/29512161/extending-shelf-life-of-dithiothreitol-treated-panel-rbcs-to-28-days
#13
J-P Sigle, B Mihm, R Suna, M Bargetzi
BACKGROUND: Daratumumab (DARA) causes non-specific results in indirect agglutination testing (IAT). Dithiothreitol (DTT) treatment of panel red blood cells (RBCs) abolishes DARA interference. The objective of our study was to extend stability of DTT-treated panel RBCs to 28 days through application of a commercially available panel RBC stabilizer. MATERIALS AND METHODS: Serological antigen typing and IAT using DARA sera and DARA plasma spiked with weakly reacting alloantibodies was performed up to 28 days after DTT treatment and stabilization...
March 7, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29504337/red-cell-alloimmunization-in-multitransfused-thalassaemia-major-patients
#14
Shazia Moeen, Nazish Farooq, Romana Irshad, Muhammad Ashfaq, Umer Farooq, Muhammad Idris
BACKGROUND: Lifelong transfusions are life savers for thalassaemia patients but are associated with many complications. Alloimmunization is a major problem for blood banks. Antigens of foreign red blood cells induce the formation of antibodies in patients suffering from thalassaemia. The purpose of this study was to examine the frequency of red cell alloantibodies and to express the type of these antibodies in thalassaemia patients. METHODS: Patients that have received multiple transfusions were included in this study...
January 2018: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29492974/abo-and-d-typing-and-alloantibody-screening-in-marrow-samples-relevance-to-intraosseous-blood-transfusion
#15
Sari Bäckman, Susanne Ångerman-Haasmaa, Milla Jousi, Sanna Siitonen, Katja Salmela
BACKGROUND: Blood transfusion through the intraosseous route is gaining popularity in emergency medicine. Pretransfusion peripheral blood (PB) samples are usually not available in these patients, leading to discrepancies in blood group typing and a possible delay in transferring to group-specific blood products. The aim of this study was to assess the feasibility of ABO and D typing and red blood cell alloantibody screening in marrow (BM) samples. STUDY DESIGN AND METHODS: Direct and reverse ABO typing, D typing, and a two-cell alloantibody screen were performed in EDTA-anticoagulated BM samples with standard manual column agglutination techniques...
March 1, 2018: Transfusion
https://www.readbyqxmd.com/read/29460456/acute-haemolysis-dic-and-renal-failure-after-transfusion-of-uncross-matched-blood-during-trauma-resuscitation-illustrative-case-and-literature-review
#16
J Fiorellino, A L Elahie, T E Warkentin
AIMS/OBJECTIVES: The aims of this study were to report a patient with acute haemolytic transfusion reaction (HTR) after transfusing uncross-matched red blood cell (RBC) units and to identify the frequency of this complication. BACKGROUND: Uncross-matched RBC units are commonly transfused in emergencies, but the frequency of acute HTR is unknown. METHODS: We describe a male stabbing victim who received three units of uncross-matched RBC units complicated by acute intravascular HTR, disseminated intravascular coagulation (DIC) and renal failure...
February 19, 2018: Transfusion Medicine
https://www.readbyqxmd.com/read/29445378/fc-glycosylation-in-human-igg1-and-igg3-is-similar-for-both-total-and-anti-red-blood-cell-anti-k-antibodies
#17
Myrthe E Sonneveld, Carolien A M Koeleman, H Rosina Plomp, Manfred Wuhrer, C Ellen van der Schoot, Gestur Vidarsson
After albumin, immunoglobulin G (IgG) are the most abundant proteins in human serum, with IgG1 and IgG3 being the most abundant subclasses directed against protein antigens. The quality of the IgG-Fc-glycosylation has important functional consequences, which have been found to be skewed toward low fucosylation in some antigen-specific immune responses. This increases the affinity to IgG1-Fc-receptor (FcγR)IIIa/b and thereby directly affects downstream effector functions and disease severity. To date, antigen-specific IgG-glycosylation have not been analyzed for IgG3...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29441590/the-prevalence-immunogenicity-and-evanescence-of-alloantibodies-to-mut-and-mur-antigens-of-gp-mur-red-blood-cells-in-a-southeast-asian-patient-cohort
#18
Veera Sekaran Nadarajan
BACKGROUND: Antibodies to Mi a , MUT, and Mur are among the most frequently identified alloantibodies in Southeast Asia. Understanding the characteristics of these antibodies in terms of induction and evanescence would aid in optimizing methods for their detection. STUDY DESIGN AND METHODS: Antibody testing results between the years 2013 and 2015 with relevant patient demographic data and red blood cell (RBC) transfusion history were retrieved. Cumulative alloimmunization incidence and evanescence to MUT and Mur were estimated by Kaplan-Meier analysis in relation to the number of RBC units transfused and time...
February 13, 2018: Transfusion
https://www.readbyqxmd.com/read/29415351/considerations-for-pre-transfusion-immunohaematology-testing-in-patients-receiving-the-anti-cd38-monoclonal-antibody-daratumumab-for-the-treatment-of-multiple-myeloma
#19
Hang Quach, Simon Benson, Helen Haysom, Anne-Marie Wilkes, Nicole Zacher, Merrole Cole-Sinclair, Henry Miles Prince, Peter Mollee, Andrew Spencer, Phoebe Joy Ho, Simon J Harrison, Cindy Lee, Bradley Augustson, James Daly
In recent years, the anti-CD38 monoclonal antibody daratumumab (Darzalex; Janssen-Cilag Pty Ltd) has been shown to be highly efficacious in relapsed and refractory multiple myeloma, with the final results of treatment in newly diagnosed patients awaited. Despite awareness of the potential interference of daratumumab in pre-transfusion immunohaematology testing during phase I and II clinical studies, there was a degree of unpreparedness in the community upon the introduction of this drug into the clinics, particularly the impact that it has on the operational processes in hospital transfusion laboratories and timely issue of red blood cells (RBCs)...
February 2018: Internal Medicine Journal
https://www.readbyqxmd.com/read/29378145/assessment-of-common-red-blood-cell-pretreatments-to-yield-an-accurate-serologic-antigen-phenotype-compared-with-genotypepredicted-phenotype
#20
Trina Horn, Janis Hamilton, Joanne Kosanke, Virginia W Hare, Wendy Kluver, Wendy Beres, Sandra Nance, Margaret A Keller
For patients requiring multiple transfusions and patients with positive direct antiglobulin tests (DATs), an extended red blood cell (RBC) phenotype can provide valuable information and help to determine the risk of forming alloantibodies. In some instances, the phenotype may be used for prophylactic matching. Phenotyping in this patient population is often hindered by the presence of circulating donor cells and/or by a positive DAT. Several methods, such as EDTA glycine acid (EGA) treatment to remove IgG, hypotonic saline wash to separate autologous RBCs, or reticulocyte separation, are often used in these situations to isolate patient RBCs for serologic phenotyping...
December 2017: Immunohematology
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