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probiotics in neonates

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https://www.readbyqxmd.com/read/28100322/-association-between-risk-factors-during-maternal-pregnancy-and-the-neonatal-period-and-childhood-bronchial-asthma
#1
Hui-Qin Zhang, Rui Fan, Jing-Jing Zhang, Xiao-Juan Tao, Xin Sun
OBJECTIVE: To study the association of the risk factors during maternal pregnancy and the neonatal period with childhood bronchial asthma. METHODS: A total of 306 children with asthma (asthma group) and 250 healthy children (control group) were enrolled. Their clinical data during the neonatal period and the maternal data during pregnancy were retrospectively studied. RESULTS: The univariate analysis showed that there were significant differences in the rates of maternal use of antibiotics during pregnancy, use of antibiotics and probiotics during the neonatal period, preterm birth, cesarean section, low birth weight, and breast feeding (>6 months) between the asthma and control groups (P<0...
January 2017: Zhongguo Dang Dai Er Ke za Zhi, Chinese Journal of Contemporary Pediatrics
https://www.readbyqxmd.com/read/28092597/role-of-probiotics-in-nutrition-and-health-of-small-ruminants
#2
M M Abd El-Tawab, I M I Youssef, H A Bakr, G C Fthenakis, N D Giadinis
Small ruminants represent an important economic source in small farm systems and agriculture. Feed is the main component of livestock farming, which has gained special attention to improve animal performance. Many studies have been done to improve feed utilisation through addition of feed additives. For a long period, antibiotics have been widely used as growth promoters in livestock diets. Due to their ban in many countries, search for alternative feed additives has been intensified. Probiotics are one of these alternatives recognised to be safe to the animals...
December 1, 2016: Polish Journal of Veterinary Sciences
https://www.readbyqxmd.com/read/28056921/bifidobacterium-adolescentis-protects-against-necrotizing-enterocolitis-and-upregulates-tollip-and-sigirr-in-premature-neonatal-rats
#3
Wenshen Wu, Yanli Wang, Jingjing Zou, Fang Long, Huiheng Yan, Lijuan Zeng, Yunbin Chen
BACKGROUND: Necrotizing enterocolitis (NEC) is a serious gastrointestinal disorder that is often seen in premature infants. Probiotics decrease the risk of NEC; however, the mechanism by which probiotics work is not clear. The goal of this study was to evaluate the preventive effect of Bifidobacterium adolescentis in an NEC rat model. METHODS: Sprague-Dawley neonatal rats were obtained by caesarean section after 20-21 d gestation and randomly divided into the following 3 groups: dam fed (DF), formula fed (FF), and formula + B...
January 5, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28050461/role-of-saccharomyces-boulardii-in-reduction-of-neonatal-hyperbilirubinemia
#4
V Suganthi, A Gokul Das
INTRODUCTION: Probiotics are known to reduce the severity of hyperbilirubinemia. AIM: This study was done to evaluate the effect of probiotic on neonatal hyperbilirubinemia in term neonates. MATERIALS AND METHODS: A total of 181 healthy term neonates after birth were divided into a control group (n=95) and a treatment group (n=86) randomly and treated with placebo and probiotic (Saccharomyces boulardii) respectively. A total of two doses were given orally in the first two consecutive days...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27999620/effects-of-escherichia-coli-nissle-1917-and-ciprofloxacin-on-small-intestinal-epithelial-cell-mrna-expression-in-the-neonatal-piglet-model-of-human-rotavirus-infection
#5
Francine C Paim, Stephanie N Langel, David D Fischer, Sukumar Kandasamy, Lulu Shao, Moyasar A Alhamo, Huang-Chi Huang, Anand Kumar, Gireesh Rajashekara, Linda J Saif, Anastasia N Vlasova
We evaluated the effects of the probiotic Escherichia coli Nissle 1917 (EcN) and the antibiotic Ciprofloxacin (Cipro) on mRNA expression of intestinal epithelial cells (IEC) in gnotobiotic (Gn) piglets colonized with a defined commensal microflora (DMF) and inoculated with human rotavirus (HRV) that infects IECs. We analyzed mRNA levels of IEC genes for enteroendocrine cells [chromogranin A (CgA)], goblet cells [mucin 2 (MUC2)], transient amplifying progenitor cell [proliferating cell nuclear antigen (PCNA)], intestinal epithelial stem cell (SOX9) and enterocytes (villin)...
2016: Gut Pathogens
https://www.readbyqxmd.com/read/27998852/-isolation-identification-and-lead-adsorption-study-of-lead-resistant-lactobacillus-casei-strains-from-feces-of-healthy-newborns
#6
Wei Shen, Qin-Fei Yu, Yu-Hao Wang, Yi-Duo Zhang, Xiao-Jing Meng, Hong-Ying Fan
OBJECTIVE: To isolate and identify lead-resistant Lactobacillus casei strains with lead adsorption ability from the stool of healthy newborns as a new source of bacteria for developing lead-eliminating food products. METHODS: MRS was used to isolate lead-resistant bacteria from the feces of 30 healthy and full-term neonates. A phylogenetic tree was constructed based on the morphological characteristics and 16S rRNA sequences of the isolated bacteria. Physiological and biochemical characterizations of the bacteria were performed according to the Berger's Systematic Bacteriology Handbook, followed by antimicrobial susceptibility test and acid-tolerant bile salt test...
December 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/27893069/new-medical-and-surgical-insights-into-neonatal-necrotizing-enterocolitis-a-review
#7
Brandy L Frost, Biren P Modi, Tom Jaksic, Michael S Caplan
Importance: Necrotizing enterocolitis (NEC) has long remained a significant cause of morbidity and mortality in neonatal intensive care units. While the mainstay of treatment for this devastating condition remains largely supportive, research efforts continue to be directed toward understanding pathophysiology as well as how best to approach surgical management when indicated. Observations: In this review, we first examine recent medical observations, including overviews on the microbiome and a brief review of the use of probiotics...
January 1, 2017: JAMA Pediatrics
https://www.readbyqxmd.com/read/27882741/bacteremia-induced-by-bifidobacterium-breve-in-a-newborn-with-cloacal-exstrophy
#8
Shinichi Sato, Toshihiko Uchida, Shota Kuwana, Kazuto Sasaki, Tatsuya Watanabe, Junko Saito, Takahiro Kawaji
Bifidobacterium breve is an effective probiotic agent used in the field of neonatology. Although B. breve has been considered safe, a case of B. breve bacteremia has been reported. The pathogenic mechanism underlying the bacteremia is unknown. Herein, we report a second case of B. breve bacteremia that developed in a neonate with multiple abdominal organ anomalies. Following surgical repair immediately after birth, B. breve treatment was started. After 1 week, the infant developed B. breve bacteremia following the onset of adhesive ileus...
November 2016: Pediatrics International: Official Journal of the Japan Pediatric Society
https://www.readbyqxmd.com/read/27820846/preclinical-immunomodulation-by-the-probiotic-bifidobacterium-breve-m-16v-in-early-life
#9
Maria Del Mar Rigo-Adrover, Àngels Franch, Margarida Castell, Francisco José Pérez-Cano
This study aimed to investigate the effect of supplementation with the probiotic Bifidobacterium breve M-16V on the maturation of the intestinal and circulating immune system during suckling. In order to achieve this purpose, neonatal Lewis rats were supplemented with the probiotic strain from the 6th to the 18th day of life. The animals were weighed during the study, and faecal samples were obtained and evaluated daily. On day 19, rats were euthanized and intestinal wash samples, mesenteric lymph node (MLN) cells, splenocytes and intraepithelial lymphocytes (IEL) were obtained...
2016: PloS One
https://www.readbyqxmd.com/read/27801789/administration-of-a-multi-strain-probiotic-product-to-women-in-the-perinatal-period-differentially-affects-the-breast-milk-cytokine-profile-and-may-have-beneficial-effects-on-neonatal-gastrointestinal-functional-symptoms-a-randomized-clinical-trial
#10
Maria Elisabetta Baldassarre, Antonio Di Mauro, Paola Mastromarino, Margherita Fanelli, Domenico Martinelli, Flavia Urbano, Daniela Capobianco, Nicola Laforgia
BACKGROUND: Probiotic supplementation to women during pregnancy and lactation can modulate breast milk composition, with immune benefits being transferred to their infants. AIM: The aim of the study was to evaluate the effect of high-dose probiotic supplementation to women during late pregnancy and lactation on cytokine profile and secretory IgA (sIgA) in breast milk and thus to study if differences in breast milk composition can affect lactoferrin and sIgA levels in stool samples of newborns...
October 27, 2016: Nutrients
https://www.readbyqxmd.com/read/27793494/probiotics-prevent-candida-colonization-and-invasive-fungal-sepsis-in-preterm-neonates-a-systematic-review-and-meta-analysis-of-randomized-controlled-trials
#11
REVIEW
Hua-Jian Hu, Guo-Qiang Zhang, Qiao Zhang, Shristi Shakya, Zhong-Yue Li
To investigate whether probiotic supplementation could reduce the risk of fungal infection in preterm neonates in neonatal intensive care units (NICUs), we systematically searched PubMed, EMBASE, and the Cochrane Central Register of Controlled Trials databases for randomized controlled trials (RCTs) focusing on the effect of probiotics on fungal infection in preterm neonates. The outcomes of interest were Candida colonization and invasive fungal sepsis. Seven trials involving 1371 preterm neonates were included...
September 14, 2016: Pediatrics and Neonatology
https://www.readbyqxmd.com/read/27761306/prevention-of-necrotizing-enterocolitis-with-probiotics-a-systematic-review-and-meta-analysis
#12
Sonja C Sawh, Santosh Deshpande, Sandy Jansen, Christopher J Reynaert, Philip M Jones
CONTEXT: Necrotizing enterocolitis (NEC) is the most frequent gastrointestinal emergency in neonates. The microbiome of the preterm gut may regulate the integrity of the intestinal mucosa. Probiotics may positively contribute to mucosal integrity, potentially reducing the risk of NEC in neonates. OBJECTIVE: To perform an updated systematic review and meta-analysis on the efficacy and safety of probiotics for the prevention of NEC in premature infants. DATA SOURCES: Structured searches were performed in: Medline, Embase, and the Cochrane Central Register of Controlled Trials (all via Ovid, from 2013 to January 2015)...
2016: PeerJ
https://www.readbyqxmd.com/read/27744438/vaginal-probiotic-administration-in-the-management-of-preterm-premature-rupture-of-membranes
#13
George J Daskalakis, Alexis K Karambelas
OBJECTIVE: To examine the influence of vaginal probiotic administration as an adjunct to standard antibiotic treatment on perinatal outcome in women with preterm premature rupture of membranes (PPROM). MATERIALS AND METHODS: This was a prospective randomized trial of cases with PPROM (24-34 weeks) that were admitted to our department between 2011 and 2015. Forty-nine cases received vaginal probiotics for 10 days in combination with antibiotic prophylaxis and were compared to 57 others that received only antibiotics for the same time period...
October 15, 2016: Fetal Diagnosis and Therapy
https://www.readbyqxmd.com/read/27727257/-lactobacillus-rhamnosus-sepsis-in-a-preterm-infant-associated-with-probiotic-integrator-use-a-case-report
#14
Manuela Molinaro, Massimo Aiazzi, Antonio La Torre, Elisabetta Cini, Roberto Banfi
Preterm infants are at high risk of neonatal sepsis. We report a case of a preterm infant under prophylaxis with Lactobacillus Rhamnosus for necrotizing enterocolitis; the child develops neonatal sepsis by Lactobacillus Rhamnosus. The infection is improved after probiotic withdrawal and had complete remission after 20 days of specific antibiotic therapy.
September 2016: Recenti Progressi in Medicina
https://www.readbyqxmd.com/read/27724923/effects-of-probiotics-vivomixx%C3%A2-in-obese-pregnant-women-and-their-newborn-study-protocol-for-a-randomized-controlled-trial
#15
Sofie Ingdam Halkjaer, Lisbeth Nilas, Emma Malchau Carlsen, Dina Cortes, Thórhallur Ingi Halldórsson, Sjúrdur Frodi Olsen, Anders Elm Pedersen, Karen Angeliki Krogfelt, Andreas Munk Petersen
BACKGROUND: Maternal obesity is associated with increased risks of adverse pregnancy-related complications and outcomes for both mothers and infants. Overweight and obese women have an increased risk of pregnancy-induced hypertension, preeclampsia and gestational diabetes mellitus (GDM). Infant Body Mass index (BMI) and the risk of obesity in adulthood are related to maternal gestational weight gain (GWG). Preventive lifestyle and dietary interventions are time-consuming and do not always reduce GWG or the risk of maternal pregnancy complications...
October 11, 2016: Trials
https://www.readbyqxmd.com/read/27671183/efficacy-of-probiotics-versus-placebo-in-the-prevention-of-necrotizing-enterocolitis-in-preterm-very-low-birth-weight-infants-a-double-blind-randomized-controlled-trial
#16
Tanjina Chowdhury, Muhammad Manajjir Ali, Muhammad Monir Hossain, Jugindra Singh, Abu Noyeem Muhammad Yousuf, Fatema Yasmin, Fazle Rabbi Chowdhury
OBJECTIVE: To evaluate the efficacy of orally administered probiotics in preventing necrotizing enterocolitis (NEC) in preterm very low birth weight (VLBW) infants. STUDY DESIGN: Arandomized double blind controlled trial. PLACE AND DURATION OF STUDY: The Paediatrics Department of Sylhet M.A.G. Osmani Medical College Hospital, Sylhet Bangladesh, from July 2012 to June 2015. METHODOLOGY: Preterm (28 - 33 weeks gestation) VLBW (birth weight 1000 - 1499 g) neonates were enrolled...
September 2016: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/27647578/exploring-hypotheses-and-rationale-for-causes-of-infantile-colic
#17
M Camilleri, S-Y Park, E Scarpato, A Staiano
BACKGROUND: Infantile colic is a frequent problem in neonates and infants. This review addresses current management including the results for nutrient modifications; soy-based formulas; and prebiotics, probiotics, and synbiotics. PURPOSE: Given the evidence that there is still an unmet clinical need, as current treatments are incompletely efficacious, we have examined the evidence around three hypothetical mechanisms that could potentially be involved in etiopathogenesis of infantile colic: immaturity of bile acid mechanisms that alter intraluminal and absorptive mechanisms, immaturity in motility and alterations in the microbiome...
September 20, 2016: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/27633108/probiotics-prebiotics-and-synbiotics-for-the-prevention-of-necrotizing-enterocolitis
#18
REVIEW
Kathene C Johnson-Henry, Thomas R Abrahamsson, Richard You Wu, Philip M Sherman
Necrotizing enterocolitis (NEC) is a devastating intestinal disease in preterm infants characterized by barrier disruption, intestinal microbial dysbiosis, and persistent inflammation of the colon, which results in high mortality rates. Current strategies used to manage this disease are not sufficient, although the use of human breast milk reduces the risk of NEC. Mother's milk is regarded as a fundamental nutritional source for neonates, but pasteurization of donor breast milk affects the composition of bioactive compounds...
September 2016: Advances in Nutrition
https://www.readbyqxmd.com/read/27583387/survey-and-evidence-based-review-of-probiotics-used-in-very-low-birth-weight-preterm-infants-within-the-united-states
#19
S Viswanathan, C Lau, H Akbari, C Hoyen, M C Walsh
OBJECTIVE: Data from multiple clinical trials, mostly conducted outside the US, indicate that probiotic prophylaxis is an effective intervention for prevention of necrotizing enterocolitis (NEC) in preterm infants. Probiotics are routinely used in many countries. However, in the US, probiotic use in preterm infants is limited (6.7% of very low birth weight (VLBW) infants in the US were exposed to probiotics in 2014, Vermont Oxford Network (VON)). Probiotic products are often considered in 'generic' terms, but considerable variation exists between commercially available probiotics in terms of their quantity and quality...
December 2016: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/27577791/homage-to-the-h-in-developmental-origins-of-health-and-disease
#20
C S Rosenfeld
Abundant evidence exists linking maternal and paternal environments from pericopconception through the postnatal period to later risk to offspring diseases. This concept was first articulated by the late Sir David Barker and as such coined the Barker Hypothesis. The term was then mutated to Fetal Origins of Adult Disease and finally broadened to developmental origins of adult health and disease (DOHaD) in recognition that the perinatal environment can shape both health and disease in resulting offspring. Developmental exposure to various factors, including stress, obesity, caloric-rich diets and environmental chemicals can lead to detrimental offspring health outcomes...
February 2017: Journal of Developmental Origins of Health and Disease
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