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https://www.readbyqxmd.com/read/29621951/patient-level-outcomes-and-virologic-suppression-rates-in-hiv-infected-patients-receiving-antiretroviral-therapy-in-rwanda
#1
David J Riedel, Kristen A Stafford, Peter Memiah, Modupe Coker, Cyprien Baribwira, Jackson Sebeza, Eva Karorero, Sabin Nsanzimana, Fernando Morales, Robert R Redfield
The Rwanda national HIV program has been successful at scaling up antiretroviral therapy (ART) to achieve universal access. The AIDSRelief Model of Care focuses on four key principles: (1) earlier initiation of ART; (2) use of durable, highly-potent, and sequence-friendly first-line ART regimens; (3) early detection of treatment failure; and (4) provision of community-based care and support to ensure optimal adherence and follow up/engagement in care. We conducted a retrospective cohort study of randomly-selected HIV-infected patients at AIDSRelief-supported sites using a stratified, random sample of 583 adults (>15 years) who initiated ART from 30 June 2008 to 1 February 2010...
January 1, 2018: International Journal of STD & AIDS
https://www.readbyqxmd.com/read/29547683/prevalence-of-synchronous-oligopolyposis-in-incident-colorectal-cancer-a-population-based-study
#2
Juan M Marqués-Lespier, Marievelisse Soto-Salgado, María González-Pons, Vanessa Méndez, Katerina Freyre, Carlos Beltrán, Luis R Pericchi, Marcia Cruz-Correa
OBJECTIVE: Colorectal cancer (CRC) is a leading causes of cancer death among men and women. The purpose of this study was to determine the prevalence of oligopolyposis (≥20 synchronous colorectal adenomas) and its associated clinicopathological characteristics in Hispanics with incident CRC. METHODS: Pathology reports from individuals diagnosed with CRC (2007 to 2011) were obtained from the PR Central Cancer Registry. Colorectal polyp burden was calculated using pathology reports and the data was normalized to colon segment size...
2018: Puerto Rico Health Sciences Journal
https://www.readbyqxmd.com/read/29465653/clinical-characteristics-of-anorectal-mycoplasma-genitalium-infection-and-microbial-cure-in-men-who-have-sex-with-men
#3
Jason J Ong, Ei Aung, Tim R H Read, Christopher K Fairley, Suzanne M Garland, Gerald Murray, Marcus Y Chen, Eric P F Chow, Catriona S Bradshaw
BACKGROUND: We report clinical characteristics of proctitis caused solely by Mycoplasma genitalium(MG), compared with chlamydia and gonococcus. We determined the proportions cured with first-line (azithromycin) and second-line antimicrobials (moxifloxacin, pristinamycin). METHODS: 166 patients attending Melbourne Sexual Health Centre from 2012 to 2016 with symptoms of proctitis were tested for MG, Chlamydia trachomatis and Neisseria gonorrhoeae. Demographic characteristics, sexual behaviours, clinical symptoms and signs were recorded...
January 18, 2018: Sexually Transmitted Diseases
https://www.readbyqxmd.com/read/29350695/prechemotherapy-education-reducing-patient-anxiety-through-nurse-led-teaching-sessions
#4
Emmanuel Apor, Nathan T Connell, Katherine Faricy-Anderson, Peter Barth, Rouba Youssef, Mary Fenton, William M Sikov, Anthony Thomas, Kayla Rosati, Andrew Schumacher, Alise Lombardo, Susan Korber, Humera Khurshid, Howard Safran, Anthony Mega
BACKGROUND: Patients with cancer experience stress surrounding diagnosis and treatment. Many cancer centers employ a nurse-led education session to alleviate patient anxiety and confusion.
. OBJECTIVES: The goal was to evaluate the effect of a nurse-led chemotherapy teaching session on patients' knowledge, anxiety, and preparedness for 
cancer-directed therapy.
. METHODS: After discussing treatment with their oncologist, participants completed a survey assessing their perceived understanding of various treatment topics...
February 1, 2018: Clinical Journal of Oncology Nursing
https://www.readbyqxmd.com/read/29239916/early-experience-with-clinimacs-prodigy-ccs-ifn-gamma-system-in-selection-of-virus-specific-t-cells-from-third-party-donors-for-pediatric-patients-with-severe-viral-infections-after-hematopoietic-stem-cell-transplantation
#5
Krisztián Kállay, Csaba Kassa, Marienn Réti, Éva Karászi, János Sinkó, Vera Goda, Anita Stréhn, Katalin Csordás, Orsolya Horváth, Attila Szederjesi, Szabolcs Tasnády, Apor Hardi, Gergely Kriván
Viral reactivation is a frequent complication of allogeneic hematopoietic stem cell transplantation especially in children. For refractory cases, rapid virus-specific T-cell therapy would be ideally implemented within a few days. Over the course of a year in our pediatric cohort of 43 allogeneic transplantation, 9 patients fulfilled criteria for virus-specific T-cell therapy. Viral infections were due to cytomegalovirus (CMV) in 3, Epstein-Barr virus (EBV) in 2, and adenovirus (AdV) in 1 case, whereas >1 virus was detected in 3 cases...
April 2018: Journal of Immunotherapy
https://www.readbyqxmd.com/read/29182734/quality-of-life-measured-with-euroqol-five-dimensions-questionnaire-predicts-long-term-mortality-response-and-reverse-remodelling-in-cardiac-resynchronization-therapy-patients
#6
Klaudia Vivien Nagy, Gábor Széplaki, Péter Perge, András Mihály Boros, Annamária Kosztin, Astrid Apor, Levente Molnár, Szabolcs Szilágyi, Tamás Tahin, Endre Zima, Valentina Kutyifa, László Gellér, Béla Merkely
Aims: There are previous studies on quality of life (QoL) in cardiac resynchronization therapy (CRT) patients; however, there are no data with the short EuroQol-five dimensions (EQ-5D) questionnaire predicting outcomes. We aimed to assess the predictive role of baseline QoL and QoL change at 6 months after CRT with EQ-5D on 5-year mortality and response. Methods and results: In our prospective follow-up study, 130 heart failure (HF) patients undergoing CRT were enrolled...
November 22, 2017: Europace: European Pacing, Arrhythmias, and Cardiac Electrophysiology
https://www.readbyqxmd.com/read/29179868/prevalence-and-correlates-of-cervical-hpv-infection-in-a-clinic-based-sample-of-hiv-positive-hispanic-women
#7
A P Ortiz, V Tamayo, A Scorsone, M Soto-Salgado, I Febo, P Piovanetti, H L Venegas-Ríos, Y Yamamura, C Zorrilla
OBJECTIVES: Puerto Rico (PR), is the fifth highest jurisdiction of the United States of America (US) with respect to HIV prevalence and the leading in cervical cancer incidence. This cross-sectional study describes the prevalence and correlates of cervical HPV infection among a clinic-based sample of 302 women living with HIV/AIDS in PR. METHODS: Data collection included questionnaires, blood and cervical samples. Multivariable logistic regression models were used to estimate the magnitude of association (adjusted Prevalence odds ratio [aPOR]) between HPV cervical infection and other covariates...
December 2017: Papillomavirus Research
https://www.readbyqxmd.com/read/29141100/religiosity-and-psychological-resilience-in-patients-with-schizophrenia-and-bipolar-disorder-an-international-cross-sectional-study
#8
Y Mizuno, A Hofer, B Frajo-Apor, F Wartelsteiner, G Kemmler, S Pardeller, T Suzuki, M Mimura, W W Fleischhacker, H Uchida
OBJECTIVE: The impact of religious/spiritual activities on clinical outcomes in patients with serious mental illnesses remains controversial, which was addressed in this international cross-sectional study. METHOD: Three-hundred sixty-nine subjects were recruited from Austria (n = 189) and Japan (n = 180), consisting of 112 outpatients with paranoid schizophrenia, 120 with bipolar I disorder (DSM-IV), and 137 healthy controls. Religiosity was assessed in terms of attendance and importance of religious/spiritual activities, while resilience was assessed using the 25-item Resilience Scale...
April 2018: Acta Psychiatrica Scandinavica
https://www.readbyqxmd.com/read/28992535/quality-of-life-in-schizophrenia-and-bipolar-disorder-the-impact-of-symptomatic-remission-and-resilience
#9
A Hofer, Y Mizuno, F Wartelsteiner, W Wolfgang Fleischhacker, B Frajo-Apor, G Kemmler, M Mimura, S Pardeller, C Sondermann, T Suzuki, A Welte, H Uchida
BACKGROUND: Health-related quality of life (HRQOL) is significantly affected in individuals with schizophrenia or bipolar I disorder (BD-I). The current study investigated whether symptomatic remission and resilience might differently impact HRQOL in these patients. METHODS: Fifty-two patients with schizophrenia and 60 patients suffering from BD-I from outpatient mental health services as well as 77 healthy control subjects from the general community were included into a cross-sectional study...
October 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28956642/erratum-to-impact-of-repeated-bouts-of-eccentric-exercise-on-sarcolemma-disruption-in-human-skeletal-muscle
#10
A Costa, Z Orosz, P Apor, N Csaba, S Siamilis, Z Csende, L Racz, J Tihanyi
No abstract text is available yet for this article.
September 1, 2017: Physiology International
https://www.readbyqxmd.com/read/28932489/the-impact-of-cardiac-resynchronization-therapy-on-routine-laboratory-parameters
#11
András Mihály Boros, Péter Perge, Klaudia Vivien Nagy, Astrid Apor, Zsolt Bagyura, Endre Zima, Levente Molnár, Tamás Tahin, Dávid Becker, László Gellér, Béla Merkely, Gábor Széplaki
BACKGROUND: Cardiac resynchronization therapy (CRT) in chronic heart failure has been shown to improve mortality and morbidity. However, comprehensive data are not available as concerns how circulating biomarkers reflecting different organ functions, such as serum uric acid, blood urea nitrogen (BUN), albumin, cholesterol, or various liver enzymes, change over time as a consequence of CRT. The aim of this prospective study was to overview these possible changes. METHODS: A total of 20 routine laboratory parameters were measured in 122 control subjects and in 129 patients with chronic heart failure before CRT, 6 months, and 2 years later...
March 2017: Interventional Medicine & Applied Science
https://www.readbyqxmd.com/read/28844636/factors-associated-with-routine-childhood-vaccine-uptake-and-reasons-for-non-vaccination-in-india-1998-2008
#12
Mark Rohit Francis, Hanna Nohynek, Heidi Larson, Vinohar Balraj, Venkata Raghava Mohan, Gagandeep Kang, J Pekka Nuorti
BACKGROUND: Despite almost three decades of the Universal Immunization Program in India, a little more than half the children aged 12-23months receive the full schedule of routine vaccinations. We examined socio-demographic factors associated with partial-vaccination and non-vaccination and the reasons for non-vaccination among Indian children during 1998 and 2008. METHODS: Data from three consecutive, nationally-representative, District Level Household and Facility Surveys (1998-99, 2002-04 and 2007-08) were pooled...
August 24, 2017: Vaccine
https://www.readbyqxmd.com/read/28833941/ultrastructure-and-distribution-of-antennal-sensilla-of-the-chilli-thrips-scirtothrips-dorsalis-hood-thysanoptera-thripidae
#13
Wenjing Zhu, Shihao Zhou, Shijie Wang, Dongyin Han, Junyu Chen, Yueguan Fu
The chilli thrips, Scirtothrips dorsalis Hood, is a serious pest of numerous important vegetable and ornamental crops. Various signals, especially phytochemical cues, determine the behavior of the phytophagous thrips at host selection. The sensory abilities of S. dorsalis are poorly understood although the antennae of adult are known to possess important sensory structures in orther insects. In this study, the morphology, distribution, and ultrastructure of the antennal sensilla of the S. dorsalis were examined by using scanning and transmission electron microscopy...
December 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28606213/is-emotional-intelligence-impaired-in-unaffected-siblings-of-patients-with-schizophrenia
#14
Beatrice Frajo-Apor, Georg Kemmler, Silvia Pardeller, Markus Huber, Christian Macina, Anna-Sophia Welte, Alex Hofer
OBJECTIVES: Social cognitive deficits have been discussed to be endophenotypes for schizophrenia and other serious mental illnesses. The current study aimed to assess emotional intelligence (EI) in unaffected siblings of schizophrenia patients to investigate its potential role as endophenotype for schizophrenia. METHODS: EI was measured in 56 schizophrenia patients, 57 unaffected siblings, and 127 healthy control subjects by using the Mayer-Salovey-Caruso Emotional Intelligence Test (MSCEIT)...
August 2017: Journal of the International Neuropsychological Society: JINS
https://www.readbyqxmd.com/read/28535807/identification-of-putative-olfactory-g-protein-coupled-receptors-in-crown-of-thorns-starfish-acanthaster-planci
#15
Rebecca E Roberts, Cherie A Motti, Kenneth W Baughman, Noriyuki Satoh, Michael R Hall, Scott F Cummins
BACKGROUND: In marine organisms, and in particular for benthic invertebrates including echinoderms, olfaction is a dominant sense with chemosensation being a critical signalling process. Until recently natural product chemistry was the primary investigative approach to elucidate the nature of chemical signals but advances in genomics and transcriptomics over the last decade have facilitated breakthroughs in understanding not only the chemistry but also the molecular mechanisms underpinning chemosensation in aquatic environments...
May 23, 2017: BMC Genomics
https://www.readbyqxmd.com/read/28489967/associations-of-the-polymorphisms-in-dhrs4-serping1-and-apor-genes-with-postmortem-ph-in-berkshire-pigs
#16
Jung Hye Hwang, Sang Mi An, Seul Gi Kwon, Da Hye Park, Tae Wan Kim, Deok Gyung Kang, Go Eun Yu, Il-Suk Kim, Hwa Chun Park, Jeongim Ha, Chul Wook Kim
Postmortem pH is a main factor influencing the meat quality in pigs. This study investigated the association of postmortem pH with single-nucleotide polymorphisms (SNPs) in the fourth member of the short-chain dehydrogenase/reductase family (DHRS4), the first member of serpin peptidase inhibitor, clade G (complement inhibitor) (SERPING1), and the apolipoprotein R precursor (APOR) genes in Berkshire pigs. The study included 437 pigs, and genotyping was conducted using the GoldenGate Assay (Illumina, San Diego, CA, USA)...
October 2, 2017: Animal Biotechnology
https://www.readbyqxmd.com/read/28449660/selective-measurement-of-%C3%AE-smooth-muscle-actin-why-%C3%AE-actin-can-not-be-used-as-a-housekeeping-gene-when-tissue-fibrosis-occurs
#17
Apor Veres-Székely, Domonkos Pap, Erna Sziksz, Eszter Jávorszky, Réka Rokonay, Rita Lippai, Kálmán Tory, Andrea Fekete, Tivadar Tulassay, Attila J Szabó, Ádám Vannay
BACKGROUND: Prevalence of fibroproliferative diseases, including chronic kidney disease is rapidly increasing and has become a major public health problem worldwide. Fibroproliferative diseases are characterized by increased expression of α smooth muscle actin (α-SMA) that belongs to the family of the six conserved actin isoforms showing high degree homology. The aim of the present study was to develop real-time PCRs that clearly discriminate α-SMA and ß-actin from other actin isoforms...
April 27, 2017: BMC Molecular Biology
https://www.readbyqxmd.com/read/28290178/multiple-valvular-complications-of-hypereosinophilic-syndrome
#18
Zoltán Pozsonyi, Szabolcs Benedek, Pál Sármán, Lívia Jánoskuti, Tivadar Hüttl, Astrid Apor
Endomyocardial fibrosis (EMF) is the most common cardiac abnormality in hyeperosinophilic syndrome (HES), sometimes complicated with mitral valve disease. Mitral valve disease without ventricular manifestation is very rare, however. Case reports link HES to prosthetic valve thrombosis (PVT), but the optimal type of prosthetic valve in HES is not known. Herein is reported the case of a young female HES patient with secondary mitral valve degeneration and severe regurgitation. A mechanical prosthetic valve was implanted six months after she was diagnosed with HES, but despite anticoagulation and antiplatelet therapy she developed PVT three months later...
November 2016: Journal of Heart Valve Disease
https://www.readbyqxmd.com/read/28253513/microarray-analysis-reveals-increased-expression-of-matrix-metalloproteases-and-cytokines-of-interleukin-20-subfamily-in-the-kidneys-of-neonate-rats-underwent-unilateral-ureteral-obstruction-a-potential-role-of-il-24-in-the-regulation-of-inflammation-and-tissue
#19
Domonkos Pap, Erna Sziksz, Zoltán Kiss, Réka Rokonay, Apor Veres-Székely, Rita Lippai, István Márton Takács, Éva Kis, Andrea Fekete, György Reusz, Attila J Szabó, Adam Vannay
BACKGROUND/AIMS: Congenital obstructive nephropathy (CON) is the main cause of pediatric chronic kidney diseases leading to renal fibrosis. High morbidity and limited treatment opportunities of CON urge the better understanding of the underlying molecular mechanisms. METHODS: To identify the differentially expressed genes, microarray analysis was performed on the kidney samples of neonatal rats underwent unilateral ureteral obstruction (UUO). Microarray results were then validated by real-time RT-PCR and bioinformatics analysis was carried out to identify the relevant genes, functional groups and pathways involved in the pathomechanism of CON...
2017: Kidney & Blood Pressure Research
https://www.readbyqxmd.com/read/28243934/risky-sex-and-hiv-acquisition-among-hiv-serodiscordant-couples-in-zambia-2002-2012-what-does-alcohol-have-to-do-with-it
#20
Dvora Joseph Davey, William Kilembe, Kristin M Wall, Naw Htee Khu, Ilene Brill, Bellington Vwalika, Elwyn Chomba, Joseph Mulenga, Amanda Tichacek, Marjan Javanbakht, W Scott Comulada, Susan Allen, Pamina M Gorbach
In this paper we evaluate the effects of heavy alcohol consumption on sexual behavior, HIV acquisition, and antiretroviral treatment (ART) initiation in a longitudinal open cohort of 1929 serodiscordant couples in Lusaka, Zambia from 2002 to 2012. We evaluated factors associated with baseline heavy alcohol consumption and its association with condomless sex with the study partner, sex outside of the partnership, and ART initiation using multivariable logistic regression. We estimated the effect of alcohol consumption on HIV acquisition using multivariable Cox models...
July 2017: AIDS and Behavior
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