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https://www.readbyqxmd.com/read/28342568/erratum-to-%C3%A2-availability-of-resources-for-patients-with-wet-age-related-macular-degeneration-optimal-study%C3%A2-arch-soc-esp-oftalmol-88-8-2013-307-312
#1
R Casaroli-Marano, M Roura
No abstract text is available yet for this article.
March 22, 2017: Archivos de la Sociedad Española de Oftalmología
https://www.readbyqxmd.com/read/28318717/-individualized-management-of-patients-with-exudative-amd-ioi-protocol-injection-observational-individualization
#2
O Semoun, S Y Cohen, M Srour, C Creuzot-Garchet, H Oubraham-Mebroukine, L Kodjikian, F Devin, E H Souied
Wet macular degeneration remains a major cause of visual impairment in people over 55years. Through a group of experts belonging to the Federation France Macula, we review the treatment of wet AMD and provide recommendation with a 3 phases protocol called IOI.
March 16, 2017: Journal Français D'ophtalmologie
https://www.readbyqxmd.com/read/28315863/circulating-mirnas-as-potential-biomarkers-of-age-related-macular-degeneration
#3
Chengda Ren, Qingyu Liu, Qingquan Wei, Wenting Cai, Mengmei He, Yaru Du, Ding Xu, Yan Wu, Jing Yu
Backgroud: Age-related macular degeneration (AMD) is one of the leading causes of irreversible blindness of the elder people. This research was intended to demonstrate the different expression of microRNAs (miRNA) in AMD patients and whether they can be used as biomarkers for AMD. METHODS: MiRNAs expression was measured by microarray of 6 AMD cases and 6 gender matched controls. In a larger-sample case-control study with 126 AMD cases and 140 controls, whole blood samples were detected for the differences of miRNA expression...
March 16, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28302534/experience-of-anti-vegf-treatment-and-clinical-levels-of-depression-and-anxiety-in-patients-with-wet-age-related-macular-degeneration
#4
Hugo Senra, Konstantinos Balaskas, Neda Mahmoodi, Tariq Aslam
PURPOSE: To investigate detailed patient experiences specific to receiving vascular endothelial growth factor inhibitors (anti-VEGF) for wet Age-Related Macular Degeneration (wAMD), and to acquire a snapshot of the frequency of clinically significant levels of depression, anxiety and post-traumatic stress among patients and levels of burden in patients' carers. DESIGN: Observational cross-sectional mixed-methods study METHODS: 300 patients with wAMD receiving anti-VEGF treatment and 100 patient carers were recruited...
March 13, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28279730/efficacy-of-aflibercept-eylea-%C3%A2-on-inhibition-of-human-vegf-in-vitro
#5
M Schicht, K Hesse, H Schröder, E Naschberger, W Lamprecht, F Garreis, F P Paulsen, L Bräuer
INTRODUCTION: Pathological formation of blood vessels plays a key role in the growth and metastasis of tumors and also in several serious ophthalmological diseases such as wet age-related macular degeneration (AMD) or diabetic retinopathy. In AMD treatment, aflibercept (tradename EYLEA(®)) is used to deactivate the underlying pathological neovascularisation. Aflibercept is a recombinant fusion protein which binds to vascular endothelial growth factor (VEGF) receptors, thereby inhibiting VEGF pathway activation...
March 7, 2017: Annals of Anatomy, Anatomischer Anzeiger: Official Organ of the Anatomische Gesellschaft
https://www.readbyqxmd.com/read/28260367/-the-pharmacogenomics-of-cfh-y402h-and-wet-age-related-macular-degeneration
#6
L L Chen, Y Y Chen
Age-related macular degeneration(AMD) is one of the main leading causes of irreversible vision damage in patients over 50 years old. Genetic factors play an important role in the occurrence and development of AMD. Since the significant correlation between complement factor H (CFH) gene and AMD was found, the pharmacogenomics of CFH polymorphism was paid close attention by academic circles. Among which, studies concerning CFH Y402H were more deeply. Studies have found CFH Y402H genotypes might lead to differences toward the outcome of PDT and anti-VEGF treatment...
February 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
https://www.readbyqxmd.com/read/28251084/the-vitreomacular-interface-in-different-types-of-age-related-macular-degeneration
#7
Mohamed Abd ElMonaem El-Hifnawy, Hisham Ali Ibrahim, Amir Ramadan Gomaa, Mohamed A Elmasry
AIM: To evaluate the vitreomacular interface in cases with wet age-related macular degeneration (AMD) and to compare them to eyes with dry AMD and normal eyes. METHODS: This was a cross-sectional comparative study that included 87 eyes with wet AMD, 42 eyes with dry AMD and 40 eyes without AMD as a control group. Optical coherence tomography (OCT) examination was performed for all patients to assess the vitreomacular interface. RESULTS: In the wet AMD group, 34...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28245970/gene-therapy-in-neovascular-age-related-macular-degeneration-three-year-follow-up-of-a-phase-1-randomised-dose-escalation-trial
#8
Ian J Constable, Chooi-May Lai, Aaron L Magno, Martyn A French, Samuel B Barone, Steven D Schwartz, Mark S Blumenkranz, Mariapia A Degli-Esposti, Elizabeth P Rakoczy
PURPOSE: To assess the safety of rAAV.sFlt-1 subretinal injection in neovascular age-related macular degeneration (wet AMD) over 36 months. DESIGN: Phase 1 dose escalation trial. METHODS: Eight subjects with advanced, treatment-experienced wet AMD were randomly assigned (3:1) to treatment and non-gene therapy control groups. Eligible subjects were ≥65 years, had wet AMD and best corrected visual acuity (BCVA) 10/200 -20/80 in the study eye and 20/200 or better in the other eye...
February 25, 2017: American Journal of Ophthalmology
https://www.readbyqxmd.com/read/28243361/nutritional-supplementation-inhibits-the-increase-in-serum-malondialdehyde-in-patients-with-wet-age-related-macular-degeneration
#9
Toshiyuki Matsuura, Kei Takayama, Hiroki Kaneko, Fuxiang Ye, Hiroshi Fukukita, Taichi Tsunekawa, Keiko Kataoka, Shiang-Jyi Hwang, Yosuke Nagasaka, Yasuki Ito, Hiroko Terasaki
Purpose. To compare serum levels of malondialdehyde (MDA) in patients with wet age-related macular degeneration (wAMD), patients with dry AMD (dAMD), and patients without AMD and to evaluate the efficacy of nutritional supplementation for treating elevated serum MDA in patients with wAMD. Methods. MDA levels were measured in sera from 20 patients with wAMD, 20 with dAMD, and 24 without AMD. Patients with wAMD were randomized to receive or not receive nutritional supplementation (10 patients in each group), and MDA levels were measured after 3 months of treatment...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28225799/sf-6d-utility-values-for-the-better-and-worse-seeing-eye-for-health-states-based-on-the-snellen-equivalent-in-patients-with-age-related-macular-degeneration
#10
Martijn S Visser, Sankha Amarakoon, Tom Missotten, Reinier Timman, Jan J Busschbach
OBJECTIVE: Economic evaluations in wet age-related macular degeneration (ARMD) is hampered as often utility values for solely one eye are used, mostly the better-seeing eye (BSE). Moreover, frequently chosen methods rely on patient values and/or disease specific measures, while economic evaluations prefer generic quality of life (QoL) measures based on societal preferences. The generic QoL utility instrument EQ-5D has shown to be insensitive for differences in visual acuity. The aim of this study was therefore to provide societal utility values, using the generic SF-6D, for health states acknowledging both BSE and worse-seeing eye (WSE)...
2017: PloS One
https://www.readbyqxmd.com/read/28225373/outer-retinal-tubulation-a-case-series
#11
Leticia A Rousso, Julie A Rodman, Brad Sutton, Diana L Shechtman
PURPOSE: The advent of spectral domain optical coherence tomography has led to superb imaging capabilities in addition to enhanced visualization of the retinal layers. Such advancements have led to the identification of a variety of new retinal conditions, including outer retinal tubulations (ORTs). ORTs are ovoid hyporeflective spaces located in the outer retina. The pathogenesis is unclear but seems to involve sublethal injury to the photoreceptors leading to a compensatory reorganization of the photoreceptor layer with the neighboring ellipsoid zone resulting in a hyperreflective border surrounding a central lumen...
March 2017: Optometry and Vision Science: Official Publication of the American Academy of Optometry
https://www.readbyqxmd.com/read/28209985/ig-like-domain-6-of-vcam-1-is-a-potential-therapeutic-target-in-tnf%C3%AE-induced-angiogenesis
#12
Taek-Keun Kim, Chang Sik Park, Hee-Jun Na, Kangseung Lee, Aerin Yoon, Junho Chung, Sukmook Lee
Tumor necrosis factor alpha (TNFα)-induced angiogenesis plays important roles in the progression of various diseases, including cancer, wet age-related macular degeneration, and rheumatoid arthritis. However, the relevance and role of vascular cell adhesion molecule-1 (VCAM-1) in angiogenesis have not yet been clearly elucidated. In this study, VCAM-1 knockdown shows VCAM-1 involvement in TNFα-induced angiogenesis. Through competitive blocking experiments with VCAM-1 Ig-like domain 6 (VCAM-1-D6) protein, we identified VCAM-1-D6 as a key domain regulating TNFα-induced vascular tube formation...
February 17, 2017: Experimental & Molecular Medicine
https://www.readbyqxmd.com/read/28152206/nursing-actions-that-create-a-sense-of-good-nursing-care-in-patients-with-wet-age-related-macular-degeneration
#13
Åsa Emsfors, Lennart Christensson, Carina Elgán
BACKGROUND: People who suffer from wet age-related macular degeneration (AMD) risk central vision loss. Treatment with anti-VEGF is the only available option at present that preserves vision and no definitive cure currently exists. Patients feel that they are compelled to accept this treatment because they might otherwise become blind. AIM: To identify and describe nursing actions performed by nurses that create a sense of good nursing care in patients with wet (AMD)...
February 2, 2017: Journal of Clinical Nursing
https://www.readbyqxmd.com/read/28149783/efficacy-and-safety-of-ranibizumab-for-wet-age-related-macular-degeneration-in-chinese-patients
#14
Hui-Jun Qi, Xiao-Xin Li, Jun-Yan Zhang, Ming-Wei Zhao
AIM: To evaluate the clinical efficacy and safety of ranibizumab for wet age-related macular degeneration (wAMD) in Chinese patients and to determine the mean number of injections administered over one year of follow-up. METHODS: This single centre, retrospective observational case series study included data from 121 patients with wAMD (121 eyes) who were diagnosed by indirect ophthalmoscopy, fluorescence fundus angiography (FFA), indocyanine green angiography, and optical coherence tomography...
2017: International Journal of Ophthalmology
https://www.readbyqxmd.com/read/28132078/targeting-the-tight-junction-protein-zonula-occludens-1-with-the-connexin43-mimetic-peptide-%C3%AE-ct1-reduces-vegf-dependent-rpe-pathophysiology
#15
Elisabeth Obert, Randy Strauss, Carlene Brandon, Christina Grek, Gautam Ghatnekar, Robert Gourdie, Bärbel Rohrer
A critical target tissue in age-related macular degeneration (AMD) is the retinal pigment epithelium (RPE), which forms the outer blood-retina barrier (BRB). RPE-barrier dysfunction might result from attenuation/disruption of intercellular tight junctions. Zonula occludens-1 (ZO-1) is a major structural protein of intercellular junctions. A connexin43-based peptide mimetic, αCT1, was developed to competitively block interactions at the PDZ2 domain of ZO-1, thereby inhibiting ligands that selectively bind to this domain...
January 28, 2017: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/28104803/microrna-processing-enzymes-are-essential-for-survival-and-function-of-mature-retinal-pigmented-epithelial-cells-in-mice
#16
Thomas R Sundermeier, Sanae Sakami, Bhubanananda Sahu, Scott J Howell, Songqi Gao, Zhiqian Dong, Marcin Golczak, Akiko Maeda, Krzysztof Palczewski
Age-related macular degeneration (AMD) is a major cause of irreversible vision loss. The neovascular or "wet" form of AMD can be treated to varying degrees with anti-angiogenic drugs, but geographic atrophy (GA) is an advanced stage of the more prevalent "dry" form of AMD for which there is no effective treatment. Development of GA has been linked to loss of the microRNA (miRNA)-processing enzyme DICER1 in the mature retinal pigmented epithelium (RPE). This loss results in the accumulation of toxic transcripts of Alu transposable elements, which activate the NLRP3 inflammasome and additional downstream pathways that compromise the integrity and function of the RPE...
February 24, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28096652/erratum-macular-morphology-and-response-to-ranibizumab-treatment-in-patients-with-wet-age-related-macular-degeneration-corrigendum
#17
(no author information available yet)
[This corrects the article on p. 1117 in vol. 10, PMID: 27366051.].
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28046346/su-g-tep3-05-in-vitro-demonstration-of-endothelial-dose-enhancement-due-to-gold-nanoparticles-during-low-voltage-radiotherapy
#18
S Yasmin-Karim, M Moreau, R Kumar, G M Makrigiorgos, J Hanlon, M Arnoldussen, J Hempstead, J Celli, W Ngwa
PURPOSE: Oraya Therapy uses low-voltage, stereotactic, highly targeted X-rays for the treatment of wet age-related macular degeneration (AMD) - offering a new option for patients worldwide. Neovascular endothelial cells play a crucial role in the pathogenesis of this disease. This in-vitro study investigates the potential of gold nanoparticles (GNP) to enhance endothelial cell damage during low-voltage radiotherapy towards potential applications in the treatment of wet-AMD. METHODS: Primary human umbilical cord vein endothelium cells (HUVEC) were treated with 1...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28008223/physician-patient-and-caregiver-experience-of-different-wet-age-related-macular-degeneration-anti-vegf-treatment-regimens-in-japan-a-qualitative-assessment
#19
Tomohiro Iida, Keirei Ishii
PURPOSE: The purpose of this study was to monitor anti-vascular endothelial growth factor (anti-VEGF) treatment regimens for wet age-related macular degeneration (wAMD) in clinical practice and to determine how they impact the physician, patient, and caregiver treatment experience. MATERIALS AND METHODS: This was a qualitative analysis based on semistructured interviews with 20 ophthalmologists who had practiced both pro re nata (PRN) and treat-and-extend (T&E) anti-VEGF regimens for wAMD...
2016: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28008222/evaluation-of-peripheral-fundus-autofluorescence-in-eyes-with-wet-age-related-macular-degeneration
#20
Tetsuyuki Suetsugu, Aki Kato, Munenori Yoshida, Tsutomu Yasukawa, Akiko Nishiwaki, Norio Hasegawa, Hideaki Usui, Yuichiro Ogura
PURPOSE: We aimed to evaluate the prevalence of abnormal peripheral fundus autofluorescence (FAF) in wet age-related macular degeneration (AMD) using wide-field imaging instrument. PATIENTS AND METHODS: A retrospective, case-controlled study involving 66 eyes of 46 Japanese wet AMD patients and 32 eyes of 20 control patients was performed. Wide-field FAF images were obtained for typical AMD (37 eyes/28 patients), polypoidal choroidal vasculopathy (PCV) (22 eyes/20 patients), and retinal angiomatous proliferation (RAP) (seven eyes/four patients)...
2016: Clinical Ophthalmology
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