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https://www.readbyqxmd.com/read/28941979/proteolytic-degradation-and-inflammation-play-critical-roles-in-polypoidal-choroidal-vasculopathy
#1
Sandeep Kumar, Hiroyuki Nakashizuka, Alex Jones, Alyssia Lambert, Xuchen Zhao, Megan Shen, Mackenzie Parker, Shixian Wang, Zachary Berriochoa, Amrita Fnu, Stephanie VanBeuge, Patricia Chévez-Barrios, Mark Tso, Jon Rainier, Yingbin Fu
Polypoidal choroidal vasculopathy (PCV) is a common subtype of wet age-related macular degeneration (AMD) in Asian populations while choroidal neovascularization (CNV) is the typical subtype in Western populations. The etiology of PCV is unknown. By comparing the phenotype of a PCV mouse model expressing protease HTRA1 in retinal pigment epithelium with transgenic mice expressing the inactive HTRA1(S328A), we showed that HTRA1 mediated degradation of elastin in choroidal vessels is critical for the development of PCV, which exhibited destructive extracellular matrix remodeling and vascular smooth muscle cell loss...
September 20, 2017: American Journal of Pathology
https://www.readbyqxmd.com/read/28937825/tanshinone-iia-inhibits-vegf-secretion-and-hif-1%C3%AE-expression-in-cultured-human-retinal-pigment-epithelial-cells-under-hypoxia
#2
Rami M Alzhrani, Qasim Alhadidi, Rinda Devi Bachu, Zahoor Shah, Surajit Dey, Sai Hs Boddu
PURPOSE: The current work intends to study the activity of tanshinone IIA on secretion of vascular endothelial growth factor (VEGF) and expression of hypoxia inducible factor 1α (HIF-1α) in human retinal pigment epithelial cells (ARPE-19 cells) under hypoxic condition. METHODS: The cytotoxicity of tanshinone IIA was tested in ARPE-19 cells by MTT assay. ARPE-19 cells were incubated with different concentrations of cobalt chloride (100, 150, and 200 µM) for 12 h, and levels of expressed HIF-1α and secreted VEGF were quantified through Western blot and ELISA, respectively...
September 22, 2017: Current Eye Research
https://www.readbyqxmd.com/read/28930884/rate-of-macular-ganglion-cell-inner-plexiform-layer-thinning-in-glaucomatous-eyes-with-vascular-endothelial-growth-factor-inhibition
#3
Won June Lee, Young Kook Kim, Yong Woo Kim, Jin Wook Jeoung, Seok Hwan Kim, Jang Won Heo, Hyeong Gon Yu, Ki Ho Park
PURPOSE: To evaluate the rate of progressive macular ganglion cell-inner plexiform layer (GCIPL) thinning in patients with open-angle glaucoma (OAG) who had been treated with intravitreal anti-vascular endothelial growth factor (VEGF) injection for wet age-related macular degeneration (AMD). METHODS: This study was a retrospective modified case control study with fellow-eye comparison. We enrolled bilateral OAG patients who had been treated with repeated anti-VEGF injections for unilateral wet AMD and followed-up on for a minimum of 24 months by Cirrus high-definition optical coherence tomography (HD-OCT)...
September 19, 2017: Journal of Glaucoma
https://www.readbyqxmd.com/read/28928087/complement-factor-h-in-amd-bridging-genetic-associations-and-pathobiology
#4
REVIEW
Christopher B Toomey, Lincoln V Johnson, Catherine Bowes Rickman
AMD is a complex multifactorial disease characterized in its early stages by lipoprotein accumulations in BrM, seen on fundoscopic exam as drusen, and in its late forms by neovascularization ("wet") or geographic atrophy of the RPE cell layer ("dry"). Genetic studies have strongly supported a relationship between the alternative complement cascade, in particular the common H402 variant in Complement Factor H (CFH) and development of AMD. However, the functional significance of the CFH Y402H polymorphism remains elusive...
September 16, 2017: Progress in Retinal and Eye Research
https://www.readbyqxmd.com/read/28922378/relationships-of-orientation-discrimination-threshold-and-visual-acuity-with-macular-lesions-in-age-related-macular-degeneration
#5
Haojie Fu, Bin Zhang, Jianliang Tong, Harold Bedell, Hecheng Zhang, Yating Yang, Chaochao Nie, Yingdong Luo, Xiaoling Liu
PURPOSE: To measure visual acuity and metamorphopsia in patients with age-related macular degeneration (AMD) and to explore their relationship with macular lesions. METHODS: In this cross-sectional study, a total of 32 normal subjects (32 eyes) and 35 AMD patients (35 eyes) were recruited. They were categorized into 4 groups: normal, dry AMD, non-active wet AMD, and active wet AMD. Best-corrected visual acuity (BCVA) was measured using the Early Treatment Diabetic Retinopathy Study protocol...
2017: PloS One
https://www.readbyqxmd.com/read/28918027/adeno-associated-viral-vector-mediated-mtor-inhibition-by-short-hairpin-rna-suppresses-laser-induced-choroidal-neovascularization
#6
Tae Kwann Park, Si Hyung Lee, Jun Sub Choi, Seung Kwan Nah, Hee Jong Kim, Ha Yan Park, Heuiran Lee, Steven Hyun Seung Lee, Keerang Park
Choroidal neovascularization (CNV) is the defining characteristic feature of the wet subtype of age-related macular degeneration (AMD) and may result in irreversible blindness. Based on anti-vascular endothelial growth factor (anti-VEGF), the current therapeutic approaches to CNV are fraught with difficulties, and mammalian target of rapamycin (mTOR) has recently been proposed as a possible therapeutic target, although few studies have been conducted. Here, we show that a recombinant adeno-associated virus-delivered mTOR-inhibiting short hairpin RNA (rAAV-mTOR shRNA), which blocks the activity of both mTOR complex 1 and 2, represents a promising therapeutic approach for the treatment of CNV...
September 15, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28916483/recombinant-humanized-anti-vascular-endothelial-growth-factor-monoclonal-antibody-efficiently-suppresses-laser-induced-choroidal-neovascularization-in-rhesus-monkeys
#7
Wan-Wan Ji, Dong-An Yu, Peng Yang, Peng Fang, Yu-Xia Cao, Hu Li, Ning Xie, Shou-Sheng Yan
Neovascular age-related macular degeneration, characterized by abnormal choroidal neovascularization (CNV), is a major cause of blindness worldwide. Anti-vascular endothelial growth factor (VEGF) antibodies have demonstrated significant efficacy in improving visual acuity. TMAB001 is a new recombinant humanized rabbit anti-VEGF monoclonal antibody. It presents high activities in vitro studies. In the binding affinity assay, TMAB001 exhibited a high binding capability to VEGF with an affinity constant of 10(-11)M...
September 12, 2017: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/28913923/an-ipsc-patient-specific-model-of-cfh-y402h-polymorphism-displays-characteristic-features-of-amd-and-indicates-a-beneficial-role-for-uv-light-exposure
#8
Dean Hallam, Joseph Collin, Sanja Bojic, Valeria Chichagova, Adriana Buskin, Yaobo Xu, Lucia Lafage, Elsje G Otten, George Anyfantis, Carla Mellough, Stefan Przyborski, Sameer Alharthi, Viktor Korolchuk, Andrew Lotery, Gabriele Saretzki, Martin McKibbin, Lyle Armstrong, David Steel, David Kavanagh, Majlinda Lako
Age related macular degeneration (AMD) is the most common cause of blindness, accounting for 8.7% of all blindness globally. Vision loss is caused ultimately by apoptosis of the retinal pigment epithelium (RPE) and overlying photoreceptors. Treatments are evolving for the wet form of the disease, however these do not exist for the dry form. Complement factor H (CFH) polymorphism in exon 9 (Y402H) has shown a strong association with susceptibility to AMD resulting in complement activation, recruitment of phagocytes, retinal pigment epithelium (RPE) damage and visual decline...
September 15, 2017: Stem Cells
https://www.readbyqxmd.com/read/28898611/a-retrospective-analysis-of-the-real-life-utilization-of-ranibizumab-in-patients-with-wet-age-related-macular-degeneration-from-portugal
#9
Rufino Silva, Carla Goncalves, Angela Meireles, Carla Teixeira, Paulo Rosa, Manuel Monteiro-Grillo, Joaquim Canelas, Angela Carneiro, Rita Flores
INTRODUCTION: Anti-vascular endothelial growth factor therapy has revolutionized the treatment of wet age-related macular degeneration; however, it is important to monitor actual use of ranibizumab and related treatment outcomes in routine practice. MATERIAL AND METHODS: This was a retrospective, observational study to monitor the 2-year outcomes following ranibizumab treatment for wet age-related macular degeneration in Portugal. Patients treated between January 2009 and December 2009 were retrospectively evaluated...
June 30, 2017: Acta Médica Portuguesa
https://www.readbyqxmd.com/read/28874192/plasma-metabolomic-study-in-chinese-patients-with-wet-age-related-macular-degeneration
#10
Dan Luo, Tingting Deng, Wei Yuan, Hui Deng, Ming Jin
BACKGROUND: Age-related macular degeneration (AMD) is a leading disease associated with blindness. It has a high incidence and complex pathogenesis. We aimed to study the metabolomic characteristics in Chinese patients with wet AMD by analyzing the morning plasma of 20 healthy controls and 20 wet AMD patients for metabolic differences. METHODS: We used ultra-high-pressure liquid chromatography and quadrupole-time-of-flight mass spectrometry for this analysis. The relationship of these differences with AMD pathophysiology was also assessed...
September 6, 2017: BMC Ophthalmology
https://www.readbyqxmd.com/read/28860733/recent-developments-in-age-related-macular-degeneration-a-review
#11
REVIEW
Waseem M Al-Zamil, Sanaa A Yassin
BACKGROUND: Visual impairment in elderly people is a considerable health problem that significantly affects quality of life of millions worldwide. The magnitude of this issue is becoming more evident with an aging population and an increasing number of older individuals. OBJECTIVE: The objective of this article was to review the clinical and pathological aspects of age-related macular degeneration (AMD), diagnostic tools, and therapeutic modalities presently available or underway for both atrophic and wet forms of the disease...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/28852052/tgf-%C3%AE-participates-choroid-neovascularization-through-smad2-3-vegf-tnf-%C3%AE-signaling-in-mice-with-laser-induced-wet-age-related-macular-degeneration
#12
Xiaolei Wang, Wei Ma, Song Han, Zhaoyang Meng, Lu Zhao, Yi Yin, Yanling Wang, Junfa Li
Choroidal neovascularization(CNV) is the most severe complication in Age-related macular degeneration(AMD) and the most common cause of irreversible blindness in the elderly in developed world. The aim of this study was to identify the effect of transforming growth factor-β(TGF-β) and Smad2/3-VEGF/TNF-α signaling on CNV angiopoiesis, and to explore TGF-β inhibitors on the development of CNV in a CNV mouse model. Fundus fluorescein angiography(FFA) was used to evaluate the laser-induced CNV formation. The histology of CNV lesions stained with hematoxylin-eosin(HE) was obtained...
August 29, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28846052/association-of-htra1-rs11200638-with-age-related-macular-degeneration-amd-in-brazilian-patients
#13
Tamires Prates Lana, Sueli Matilde da Silva Costa, Galina Ananina, Fábio Endo Hirata, Priscila Hae Hyun Rim, Flávio MacCord Medina, José Paulo Cabral de Vasconcellos, Mônica Barbosa de Melo
Age-related macular degeneration is a multifactorial disease that can lead to vision impairment in older individuals. Although the etiology of age-related macular degeneration remains unknown, risk factors include age, ethnicity, smoking, hypertension, obesity, and genetic factors. Two main loci have been identified through genome-wide association studies, on chromosomes 1 and 10. Among the variants located at the 10q26 region, rs11200638, located at the HTRA1 gene promoter, has been associated with age-related macular degeneration in several populations and is considered the main polymorphism...
August 28, 2017: Ophthalmic Genetics
https://www.readbyqxmd.com/read/28846017/pharmacologic-treatment-of-wet-type-age-related-macular-degeneration-current-and-evolving-therapies
#14
Hoda Shams Najafabadi, Narsis Daftarian, Hamid Ahmadieh, Zahra-Soheila Soheili
Age-related macular degeneration as the major cause of blindness in the elderly population has remained at the epicenter of clinical research in ophthalmology. This retinal disorder is characterized by the photoreceptor and retinal pigment epithelial cells loss, occurring within the macula. The disease represents a spectrum of clinical manifestations. It is a multifactorial disease resulting from a combination of genetic predispositions and environmental risk factors. AMD is classified into two different types, dry and wet...
August 2017: Archives of Iranian Medicine
https://www.readbyqxmd.com/read/28827330/cytochrome-p450-monooxygenase-lipid-metabolites-are-significant-second-messengers-in-the-resolution-of-choroidal-neovascularization
#15
Eiichi Hasegawa, Saori Inafuku, Lama Mulki, Yoko Okunuki, Ryoji Yanai, Kaylee E Smith, Clifford B Kim, Garrett Klokman, Diane R Bielenberg, Narender Puli, John R Falck, Deeba Husain, Joan W Miller, Matthew L Edin, Darryl C Zeldin, Kin Sing Stephen Lee, Bruce D Hammock, Wolf-Hagen Schunck, Kip M Connor
Age-related macular degeneration (AMD) is the most common cause of blindness for individuals age 50 and above in the developed world. Abnormal growth of choroidal blood vessels, or choroidal neovascularization (CNV), is a hallmark of the neovascular (wet) form of advanced AMD and leads to significant vision loss. A growing body of evidence supports a strong link between neovascular disease and inflammation. Metabolites of long-chain polyunsaturated fatty acids derived from the cytochrome P450 (CYP) monooxygenase pathway serve as vital second messengers that regulate a number of hormones and growth factors involved in inflammation and vascular function...
August 21, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/28794612/investigation-of-associations-of-arms2-cd14-and-tlr4-gene-polymorphisms-with-wet-age-related-macular-degeneration-in-a-greek-population
#16
Antonia Sarli, Iosif Skalidakis, Aliki Velissari, Chryssanthi Koutsandrea, Maria Stefaniotou, Michael B Petersen, Christos Kroupis, George Kitsos, Marilita M Moschos
BACKGROUND: Age-related macular degeneration (AMD) is a multifactorial degenerative ocular disease that leads to loss of central vision. Functional gene polymorphisms have already been associated with the disease (for example, ARMS2 A69S, rs10490924). AIM: The goal of our study was to verify the correlation of the aforementioned ARMS2 variation with the disease, to examine, for the first time, the role of the CD14 C260T variation (rs2569190), and to investigate the association of two TLR4 polymorphisms (Asp299Gly or rs4986790 and Thr399Ile or rs4986791) in a Greek population with the wet form of AMD...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28761324/arms2-variants-may-predict-the-3-year-outcome-of-photodynamic-therapy-for-wet-age-related-macular-degeneration
#17
Shunichiro Nakai, Shigeru Honda, Wataru Matsumiya, Akiko Miki, Makoto Nakamura
PURPOSE: To determine the association of age-related maculopathy susceptibility2 (ARMS2) gene polymorphisms with the 3-year outcomes of photodynamic therapy (PDT) in wet age-related macular degeneration (wet AMD). METHODS: The single nucleotide polymorphism (SNP) at rs10490924 in the ARMS2 gene of 65 patients with wet AMD who underwent PDT was genotyped using the TaqMan assay. The clinical characteristics and the outcomes of PDT were compared among the three genotypes at rs10490924...
2017: Molecular Vision
https://www.readbyqxmd.com/read/28740360/visual-processing-in-patients-with-age-related-macular-degeneration-performing-a-face-detection-test
#18
Pasi Vottonen, Kai Kaarniranta, Ari Pääkkönen, Ina M Tarkka
PURPOSE: People with age-related macular degeneration (AMD) have difficulties in familiar face recognition and facial expression discrimination. Our aim was to evaluate the visual processing of faces in AMD patients and whether this would be improved by anti-vascular endothelial growth factor therapy. This was a prospective interventional cohort study. PATIENTS: Twelve patients with monocular wet AMD and 6 control subjects were recruited. Face detection processes were studied using cortical event-related potentials (ERPs)...
2017: Clinical Ophthalmology
https://www.readbyqxmd.com/read/28740073/genome-editing-abrogates-angiogenesis-in-vivo
#19
Xionggao Huang, Guohong Zhou, Wenyi Wu, Yajian Duan, Gaoen Ma, Jingyuan Song, Ru Xiao, Luk Vandenberghe, Feng Zhang, Patricia A D'Amore, Hetian Lei
Angiogenesis, in which vascular endothelial growth factor receptor (VEGFR) 2 plays an essential role, is associated with a variety of human diseases including proliferative diabetic retinopathy and wet age-related macular degeneration. Here we report that a system of adeno-associated virus (AAV)-mediated clustered regularly interspaced short palindromic repeats (CRISPR)-associated endonuclease (Cas)9 from Streptococcus pyogenes (SpCas9) is used to deplete VEGFR2 in vascular endothelial cells (ECs), whereby the expression of SpCas9 is driven by an endothelial-specific promoter of intercellular adhesion molecule 2...
July 24, 2017: Nature Communications
https://www.readbyqxmd.com/read/28736371/-multifocal-electroretinography-for-therapeutic-effect-evaluation-of-intravitreal-injection-lucentis-for-wet-age-related-macular-degeneration
#20
Rui-Hong Ju, Man-Sha He, Jin-Tong Hou, Meng-Yuan Li, Jing-Lin Zhang, Zhe-Ming Wu
OBJECTIVE: To evaluate the changes in retinal functions using multifocal electroretinography (mfERG) following intravitreal injection of Lucentis for treatment of wet age-related macular degeneration. METHODS: This prospective study was conducted in 14 patients (9 men and 5 women, 14 eyes) with wet age-related macular degeneration receiving treatment with intravitreal injections of ranibizumab (Lucentis) in our hospital between October, 2014 and January, 2016. All the patients received the treatment following a 1+PRN protocol and after the initial injection, the patients were followed up monthly for 6 months to decide if additional injections were needed...
July 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
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