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https://www.readbyqxmd.com/read/29142410/methanolic-extract-of-costus-pictus-d-don-induces-cytotoxicity-in-liver-hepatocellular-carcinoma-cells-mediated-by-histone-deacetylase-inhibition
#1
P V Neethu, K Suthindhiran, M A Jayasri
Background: Leaves of Costus pictus D. Don, (insulin plant) are used as dietary supplement for the treatment of diabetes. Objective: The antidiabetic activity of this plant is well documented, but its activity on different cell types and mechanism remains unknown. Thus, the present study evaluates the cytotoxicity of C. pictus methanolic extract (CPME) against various cancer and normal cells. Materials and Methods: Dried leaves of C. pictus were extracted using methanol and were subjected to histone deacetylase (HDAC) inhibition and toxicity studies...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29132670/food-protein-induced-enterocolitis-syndrome
#2
REVIEW
Theresa A Bingemann, Puja Sood, Kirsi M Järvinen
Food protein-induced enterocolitis syndrome (FPIES) is a non-IgE-mediated food allergy that usually presents in infancy. Cow's milk, soy, and grains are the most common food triggers. FPIES can present as a medical emergency with symptoms including delayed persistent emesis or diarrhea that can lead to severe dehydration and hemodynamic instability with abnormal laboratory markers. Diagnosis can often be made based on clinical history and noted improvement in symptoms once the suspected triggers have been removed from the diet, with oral food challenge as the gold standard for confirmation of diagnosis in unclear cases...
February 2018: Immunology and Allergy Clinics of North America
https://www.readbyqxmd.com/read/29120370/amorphous-solid-dispersion-of-epigallocatechin-gallate-for-enhanced-physical-stability-and-controlled-release
#3
Yizheng Cao, Jing Teng, Jon Selbo
Epigallocatechin gallate (EGCG) has been recognized as the most prominent green tea extract due to its healthy influences. The high instability and low bioavailability, however, strongly limit its utilization in food and drug industries. This work, for the first time, develops amorphous solid dispersion of EGCG to enhance its bioavailability and physical stability. Four commonly used polymeric excipients are found to be compatible with EGCG in water-dioxane mixtures via a stepwise mixing method aided by vigorous mechanical interference...
November 9, 2017: Pharmaceuticals
https://www.readbyqxmd.com/read/29120224/is-there-a-role-for-programmed-death-ligand-1-testing-and-immunotherapy-in-colorectal-cancer-with-microsatellite-instability-part-ii-the-challenge-of-programmed-death-ligand-1-testing-and-its-role-in-microsatellite-instability-high-colorectal-cancer
#4
Esmeralda Celia Marginean, Barbara Melosky
CONTEXT: - The world of oncology has changed dramatically in the past few years with the introduction of checkpoint inhibitors and immunotherapy. The promising findings of a small, phase 2 clinical trial that led to the US Food and Drug Administration breakthrough designation and approval of the anti-programmed death receptor-1 (PD-1) drug pembrolizumab (Keytruda, Merck, Kenilworth, New Jersey) to treat metastatic/refractory microsatellite instability-high colorectal cancer (CRC) has significantly boosted interest in immunomodulatory therapies in microsatellite instability-high CRC...
November 9, 2017: Archives of Pathology & Laboratory Medicine
https://www.readbyqxmd.com/read/29111714/quantitation-of-nine-lactones-in-dairy-cream-by-stable-isotope-dilution-assays-based-on-novel-syntheses-of-carbon-13-labeled-gamma-and-deuterium-labeled-delta-lactones-in-combination-with-gc%C3%A3-gc-tof-ms
#5
Jessica Schuett, Peter Schieberle
Lactones are well-known aroma compounds in, e.g., fruits and fermented foods as well as in dairy products such as cream or milk powders. The latter are often used in confectionary products, e.g., milk chocolate. Lactones are suggested to contribute to the distinct aroma of dairy products and have also been reported in milk chocolate. However, data on their contribution to the overall aroma of this type of chocolate are scarce. Due to their pH dependent instability and their low volatility, a reliable quantitation of lactones is a challenge...
November 7, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29105511/the-fda-oncology-center-of-excellence-and-precision-medicine
#6
Kirsten B Goldberg, Gideon M Blumenthal, Amy E McKee, Richard Pazdur
In January 2017, the U.S. Food and Drug Administration (FDA) formally established the Oncology Center of Excellence (OCE) to streamline the development of cancer therapies by uniting experts from FDA product centers to conduct expedited review of drugs, biologics, and devices. In May 2017, the FDA approved a cancer treatment based on a biomarker, without regard to the tumor's site, by granting accelerated approval to pembrolizumab for patients with solid tumors that have the microsatellite instability-high or mismatch repair deficient biomarker...
January 1, 2017: Experimental Biology and Medicine
https://www.readbyqxmd.com/read/29089060/actionable-gene-based-classification-toward-precision-medicine-in-gastric-cancer
#7
Hiroshi Ichikawa, Masayuki Nagahashi, Yoshifumi Shimada, Takaaki Hanyu, Takashi Ishikawa, Hitoshi Kameyama, Takashi Kobayashi, Jun Sakata, Hiroshi Yabusaki, Satoru Nakagawa, Nobuaki Sato, Yuki Hirata, Yuko Kitagawa, Toshiyuki Tanahashi, Kazuhiro Yoshida, Ryota Nakanishi, Eiji Oki, Dana Vuzman, Stephen Lyle, Kazuaki Takabe, Yiwei Ling, Shujiro Okuda, Kohei Akazawa, Toshifumi Wakai
BACKGROUND: Intertumoral heterogeneity represents a significant hurdle to identifying optimized targeted therapies in gastric cancer (GC). To realize precision medicine for GC patients, an actionable gene alteration-based molecular classification that directly associates GCs with targeted therapies is needed. METHODS: A total of 207 Japanese patients with GC were included in this study. Formalin-fixed, paraffin-embedded (FFPE) tumor tissues were obtained from surgical or biopsy specimens and were subjected to DNA extraction...
October 31, 2017: Genome Medicine
https://www.readbyqxmd.com/read/29072620/nutrient-content-and-nutritional-water-productivity-of-selected-grain-legumes-in-response-to-production-environment
#8
Tendai Polite Chibarabada, Albert Thembinkosi Modi, Tafadzwanashe Mabhaudhi
There is a need to incorporate nutrition into aspects of crop and water productivity to tackle food and nutrition insecurity (FNS). The study determined the nutritional water productivity (NWP) of selected major (groundnut, dry bean) and indigenous (bambara groundnut and cowpea) grain legumes in response to water regimes and environments. Field trials were conducted during 2015/16 and 2016/17 at three sites in KwaZulu-Natal, South Africa (Ukulinga, Fountainhill and Umbumbulu). Yield and evapotranspiration (ET) data were collected...
October 26, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29050066/-roles-of-pathologists-in-era-of-precision-therapy-of-cancer-comments-on-the-food-and-drug-administration-of-the-united-states-approval-of-pembrolizumab-for-microsatellite-instability-high-cancer-therapy
#9
https://www.readbyqxmd.com/read/29030181/use-of-gelatin-and-gum-arabic-for-encapsulation-of-black-raspberry-anthocyanins-by-complex-coacervation
#10
Rezvan Shaddel, Javad Hesari, Sodeif Azadmard-Damirchi, Hamed Hamishehkar, Bahram Fathi-Achachlouei, Qingrong Huang
Protein-polysaccharide interactions offer opportunities for designing the new functional foods with applications in the food and pharmaceutical industries. In this work, we microencapsulated black raspberry water extracts by double emulsion technique prior to complex coacervation using gelatin and gum Arabic to diminish the instability of their anthocyanins (ANCs) as water soluble compounds, particularly under harsh processing and storage conditions. Subsequently, optical microscopy, moisture, hygroscopicity, solubility, particle size, loading capacity, zeta potential, color parameters (L*, a*, b*, C, H° and TCD), stability, Fourier transform infrared spectroscopy (FTIR), and thermal behavior were evaluated...
October 10, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28966806/the-biology-of-aging-and-cancer-a-brief-overview-of-shared-and-divergent-molecular-hallmarks
#11
REVIEW
Jan R Aunan, William C Cho, Kjetil Søreide
Aging is the inevitable time-dependent decline in physiological organ function and is a major risk factor for cancer development. Due to advances in health care, hygiene control and food availability, life expectancy is increasing and the population in most developed countries is shifting to an increasing proportion of people at a cancer susceptible age. Mechanisms of aging are also found to occur in carcinogenesis, albeit with shared or divergent end-results. It is now clear that aging and cancer development either share or diverge in several disease mechanisms...
October 2017: Aging and Disease
https://www.readbyqxmd.com/read/28964899/polychlorinated-biphenyls-pcbs-alter-dna-methylation-and-genomic-integrity-of-sheep-fetal-cells-in-a-simplified-in-vitro-model-of-pregnancy-exposure
#12
Debora A Anzalone, Silvestre Sampino, Marta Czernik, Domenico Iuso, Grazyna E Ptak
Polychlorinated biphenyls (PCBs) are persistent organic pollutants ubiquitously detectable in the environment and in the food chain. Prenatal exposure to PCBs negatively affects fetal development and produces long-term detrimental effects on child health. The present study sought to evaluate the cytotoxic and genotoxic effects of chronic PCB exposure on fetal cells during pregnancy. To this aim, sheep embryonic fibroblasts (SEF) and amniocytes (SA) were cultured in vitro in the presence of low doses of PCBs for a period of 120days, comparable to the full term of ovine pregnancy...
September 28, 2017: Toxicology in Vitro: An International Journal Published in Association with BIBRA
https://www.readbyqxmd.com/read/28964775/influence-of-physical-activity-on-addiction-parameters-of-rats-exposed-to-amphetamine-which-were-previously-supplemented-with-hydrogenated-vegetable-fat
#13
H J Segat, R C S Barcelos, V G Metz, H Z Rosa, Kr Roversi, C T D Antoniazzi, L T Vey, M Kronbauer, J C Veit, J C Piccolo, T Emanuelli, M E Burger
Amphetamine (AMPH) and its derivatives are addictive drugs used to promote and enhance alertness, motivation, willingness, courage and wellbeing. However, their chronic use is related to memory loss, emotional instability, insomnia, psychosis and paranoia. In the last decades, modern society has included processed foods, rich in trans fatty acids (TFA), in their diet, what has been related to several health problems including increased AMPH preference and self-administration. In this scenario, physical activity appears to be useful to attenuate rewarding symptoms related to addictive drugs mainly by affecting brain neuroplasticity and neurotransmission...
September 28, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28962759/o-acylation-of-chitosan-nanofibers-by-short-chain-and-long-chain-fatty-acids
#14
Zhen Zhang, Fujun Jin, Zicong Wu, Ju Jin, Feng Li, Yiliang Wang, Zhiping Wang, Shunqing Tang, Chaoxi Wu, Yifei Wang
Chitosan nanofibers (CSNFs) have potential applications in biomaterials, oil recovery and food packaging, but their instability in moist environment has limited their full utilization. Here we report that CSNFs can be O-acylated in a post-electrospinning treatment by using pyridine as catalyst and short-chain (C2, C3, C4, C5 and C6) and long-chain (C8 and C12) fatty acid anhydrates as acylation agents. The effects of O-acylation to CSNFs were analyzed in detail. FT-IR, (1)H NMR and elemental analysis indicated that the hydroxyl groups of chitosan in CSNFs were acylated in 2h...
December 1, 2017: Carbohydrate Polymers
https://www.readbyqxmd.com/read/28920390/-advance-of-heterologous-expression-study-of-eukaryote-origin-laccases
#15
Na Ning, Huijun Tan, Xinxin Sun, Jinfeng Ni
Laccases are enzymes belonging to the group of multi-copper oxidases. These enzymes are widely distributed in insects, plants, fungi and bacteria. In general, laccases can oxidize an exceptionally high number of substrates, so they have broad applications in textile, pulp, food and the degradation of lignin. However, low yield, low activity and thermo-instability of laccase in nature limit the application of laccase. High efficient heterologous expression of the protein is an effective way for solving this problem...
April 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28917104/bacteria-and-archaea-communities-in-full-scale-thermophilic-and-mesophilic-anaerobic-digesters-treating-food-wastewater-key-process-parameters-and-microbial-indicators-of-process-instability
#16
Joonyeob Lee, Seung Gu Shin, Gyuseong Han, Taewoan Koo, Seokhwan Hwang
In this study, four different mesophilic and thermophilic full-scale anaerobic digesters treating food wastewater (FWW) were monitored for 1-2years in order to investigate: 1) microbial communities underpinning anaerobic digestion of FWW, 2) significant factors shaping microbial community structures, and 3) potential microbial indicators of process instability. Twenty-seven bacterial genera were identified as abundant bacteria underpinning the anaerobic digestion of FWW. Methanosaeta harundinacea, M. concilii, Methanoculleus bourgensis, M...
December 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28879062/a-modeling-approach-to-evaluate-the-balance-between-bioactivation-and-detoxification-of-meiqx-in-human-hepatocytes
#17
Victorien Delannée, Sophie Langouët, Nathalie Théret, Anne Siegel
BACKGROUND: Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are potentially carcinogenic for humans. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is one of the most abundant HAA formed in cooked meat. MeIQx is metabolized by cytochrome P450 1A2 in the human liver into detoxificated and bioactivated products. Once bioactivated, MeIQx metabolites can lead to DNA adduct formation responsible for further genome instability. METHODS: Using a computational approach, we developed a numerical model for MeIQx metabolism in the liver that predicts the MeIQx biotransformation into detoxification or bioactivation pathways according to the concentration of MeIQx...
2017: PeerJ
https://www.readbyqxmd.com/read/28877075/microsatellite-instability-a-predictive-biomarker-for-cancer-immunotherapy
#18
Liisa Chang, Minna Chang, Hanna M Chang, Fuju Chang
Immunotherapy has shown promising results in various types of cancers. Checkpoint inhibitor drugs developed for cancer immunotherapy have been approved by the US Food and Drug Administration (FDA) for patients with advanced melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin lymphoma. In the latest announcement, the FDA has granted accelerated approval to pembrolizumab for pediatric and adult patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient solid tumors...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28851508/long-term-housing-subsidies-and-ssi-ssdi-income-creating-health-promoting-contexts-for-families-experiencing-housing-instability-with-disabilities
#19
Zachary S Glendening, Erin McCauley, Marybeth Shinn, Scott R Brown
BACKGROUND: Though disability and housing instability are discussed separately in public health literature, few studies address families at their intersection. As a result, little is known about families who experience both homelessness and disability, how many receive disability benefits like SSI and SSDI, or the influence of those benefits on health-promoting outcomes like housing stability and self-sufficiency. Moreover, no previous research compares the ability of different housing and service interventions to increase disability benefit access...
August 26, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28847110/improving-methane-production-and-anaerobic-digestion-stability-of-food-waste-by-extracting-lipids-and-mixing-it-with-sewage-sludge
#20
Dalal E Algapani, Jing Wang, Wei Qiao, Min Su, Andrea Goglio, Simon M Wandera, Mengmeng Jiang, Xiang Pan, Fabrizio Adani, Renjie Dong
Anaerobic digestion (AD) of FW shows instability due to both the presence of high lipids and accumulation of volatile fatty acids. In this study, AD of food waste (FW) was optimized by removing lipids (LRFW) and by co-digestion with sewage sludge (1:1w/w on dry matter). The results obtained showed that lipids extraction increased FW methane yield from 400 to 418mL-gVSadded(-1) under mesophilic conditions (35°C) and from 426 to 531mL-gVSadded(-1) in thermophilic conditions (55°C). Two degradation phases (k1 and k2) described FW and LRFW degradation...
November 2017: Bioresource Technology
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