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https://www.readbyqxmd.com/read/28920390/-advance-of-heterologous-expression-study-of-eukaryote-origin-laccases
#1
Na Ning, Huijun Tan, Xinxin Sun, Jinfeng Ni
Laccases are enzymes belonging to the group of multi-copper oxidases. These enzymes are widely distributed in insects, plants, fungi and bacteria. In general, laccases can oxidize an exceptionally high number of substrates, so they have broad applications in textile, pulp, food and the degradation of lignin. However, low yield, low activity and thermo-instability of laccase in nature limit the application of laccase. High efficient heterologous expression of the protein is an effective way for solving this problem...
April 25, 2017: Sheng Wu Gong Cheng Xue Bao, Chinese Journal of Biotechnology
https://www.readbyqxmd.com/read/28917104/bacteria-and-archaea-communities-in-full-scale-thermophilic-and-mesophilic-anaerobic-digesters-treating-food-wastewater-key-process-parameters-and-microbial-indicators-of-process-instability
#2
Joonyeob Lee, Seung Gu Shin, Gyuseong Han, Taewoan Koo, Seokhwan Hwang
In this study, four different mesophilic and thermophilic full-scale anaerobic digesters treating food wastewater (FWW) were monitored for 1-2years in order to investigate: 1) microbial communities underpinning anaerobic digestion of FWW, 2) significant factors shaping microbial community structures, and 3) potential microbial indicators of process instability. Twenty-seven bacterial genera were identified as abundant bacteria underpinning the anaerobic digestion of FWW. Methanosaeta harundinacea, M. concilii, Methanoculleus bourgensis, M...
September 5, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28879062/a-modeling-approach-to-evaluate-the-balance-between-bioactivation-and-detoxification-of-meiqx-in-human-hepatocytes
#3
Victorien Delannée, Sophie Langouët, Nathalie Théret, Anne Siegel
BACKGROUND: Heterocyclic aromatic amines (HAA) are environmental and food contaminants that are potentially carcinogenic for humans. 2-Amino-3,8-dimethylimidazo[4,5-f]quinoxaline (MeIQx) is one of the most abundant HAA formed in cooked meat. MeIQx is metabolized by cytochrome P450 1A2 in the human liver into detoxificated and bioactivated products. Once bioactivated, MeIQx metabolites can lead to DNA adduct formation responsible for further genome instability. METHODS: Using a computational approach, we developed a numerical model for MeIQx metabolism in the liver that predicts the MeIQx biotransformation into detoxification or bioactivation pathways according to the concentration of MeIQx...
2017: PeerJ
https://www.readbyqxmd.com/read/28877075/microsatellite-instability-a-predictive-biomarker-for-cancer-immunotherapy
#4
Liisa Chang, Minna Chang, Hanna M Chang, Fuju Chang
Immunotherapy has shown promising results in various types of cancers. Checkpoint inhibitor drugs developed for cancer immunotherapy have been approved by the US Food and Drug Administration (FDA) for patients with advanced melanoma, non-small cell lung cancer, renal cell carcinoma, bladder cancers, and refractory Hodgkin lymphoma. In the latest announcement, the FDA has granted accelerated approval to pembrolizumab for pediatric and adult patients with microsatellite instability-high (MSI-H) or mismatch repair-deficient solid tumors...
September 4, 2017: Applied Immunohistochemistry & Molecular Morphology: AIMM
https://www.readbyqxmd.com/read/28851508/long-term-housing-subsidies-and-ssi-ssdi-income-creating-health-promoting-contexts-for-families-experiencing-housing-instability-with-disabilities
#5
Zachary S Glendening, Erin McCauley, Marybeth Shinn, Scott R Brown
BACKGROUND: Though disability and housing instability are discussed separately in public health literature, few studies address families at their intersection. As a result, little is known about families who experience both homelessness and disability, how many receive disability benefits like SSI and SSDI, or the influence of those benefits on health-promoting outcomes like housing stability and self-sufficiency. Moreover, no previous research compares the ability of different housing and service interventions to increase disability benefit access...
August 26, 2017: Disability and Health Journal
https://www.readbyqxmd.com/read/28847110/improving-methane-production-and-anaerobic-digestion-stability-of-food-waste-by-extracting-lipids-and-mixing-it-with-sewage-sludge
#6
Dalal E Algapani, Jing Wang, Wei Qiao, Min Su, Andrea Goglio, Simon M Wandera, Mengmeng Jiang, Xiang Pan, Fabrizio Adani, Renjie Dong
Anaerobic digestion (AD) of FW shows instability due to both the presence of high lipids and accumulation of volatile fatty acids. In this study, AD of food waste (FW) was optimized by removing lipids (LRFW) and by co-digestion with sewage sludge (1:1w/w on dry matter). The results obtained showed that lipids extraction increased FW methane yield from 400 to 418mL-gVSadded(-1) under mesophilic conditions (35°C) and from 426 to 531mL-gVSadded(-1) in thermophilic conditions (55°C). Two degradation phases (k1 and k2) described FW and LRFW degradation...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28820942/effects-of-preheating-and-storage-temperatures-on-aroma-profile-and-physical-properties-of-citrus-oil-emulsions
#7
Ying Yang, Chengying Zhao, Guifang Tian, Chang Lu, Shaojie Zhao, Yuming Bao, David Julian McClements, Hang Xiao, Jinkai Zheng
Citrus oils are used as good carrier oil for emulsion fabrication due to their special flavor and various health-promoting functions. In this study, the effects of preheating temperature (30, 40, 50, 60, and 70 °C) and storage temperature (4, 25, and 37 °C) on aroma profiles and physical properties of three citrus-oil (i.e., mandarin, sweet orange, and bergamot oils) emulsions were systematically investigated for the first time. The results demonstrated the significant impact of temperature on aroma profile and physical properties...
September 6, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28810215/continuous-operation-of-thermophilic-food-waste-digestion-with-side-stream-ammonia-stripping
#8
Wei Zhang, Sonia Heaven, Charles J Banks
Digesters fed on food waste (high nitrogen content) were operated successfully over an extended period using sidestream biogas stripping to control total ammonia nitrogen (TAN) below inhibitory concentrations. This is the first time biogas stripping has been used to achieve stable thermophilic operation with undiluted substrate of this type. Stripping columns operated batch-wise treated the equivalent of 1.7-4.1% of digester contents daily at pH >10 and 70°C, with no detrimental effect on digestion. TKN removal was 54%, with potential to recover 3...
November 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28805832/encapsulation-of-flavonoids-in-liposomal-delivery-systems-the-case-of-quercetin-kaempferol-and-luteolin
#9
Meigui Huang, Erzheng Su, Fuping Zheng, Chen Tan
The instability of dietary flavonoids is currently a challenge for their incorporation in functional foods. This study investigated the protective effects of liposome encapsulation on a variety of flavonoids and their interaction mechanisms. It was found that the incorporation of flavonoids into the liposomal membrane was strongly dependent on their structure and loading concentration. Liposomes loading quercetin and luteolin exhibited a relatively small size and homogeneous suspension compared to those loading kaempferol...
September 20, 2017: Food & Function
https://www.readbyqxmd.com/read/28761828/formulation-of-menthol-loaded-nanostructured-lipid-carriers-to-enhance-its-antimicrobial-activity-for-food-preservation
#10
Parizad Piran, Hossein Samadi Kafil, Saeed Ghanbarzadeh, Rezvan Safdari, Hamed Hamishehkar
Purpose: Due to the antimicrobial property, menthol have significant potential for food preservation and foodstuff shelf life improvement. Nevertheless, menthol instability, insolubility, and rapid crystallization in aqueous media make it unsuitable for used in food products. This work was aimed to prepare menthol-loaded nanostructured lipid carriers (NLCs) to enhance its antimicrobial activity. Methods: Morphology, particle size and size distribution, encapsulation efficiency percent (EE%), and physical stability of the optimized formulation, prepared by hot melt homogenization method, were characterized by scanning electron microscopy, particle size analyzing, gas chromatography, and X-ray diffraction (XRD) methods...
June 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28747934/avoidant-restrictive-food-intake-disorder-in-an-11-year-old-south-american-boy-medical-and-cultural-challenges
#11
Jonah Schermbrucker, Melissa Kimber, Natasha Johnson, Sarah Kearney, Jennifer Couturier
Avoidant/Restrictive Food Intake Disorder (ARFID) is new in the DSM-5, replacing the DSM-IV-TR diagnosis of Feeding Disorder of Infancy or Early Childhood. ARFID has no age criterion, and therefore addresses eating disturbances across the lifespan. This report illustrates the case of an 11-year-old boy of Colombian ancestry with ARFID and explores the role of culture in the diagnosis of ARFID. To date, literature describing this disorder is limited. ARFID is often seen in the child and adolescent population and can have significant medical consequences, including weight loss, hemodynamic instability, and growth retardation...
July 2017: Journal of the Canadian Academy of Child and Adolescent Psychiatry
https://www.readbyqxmd.com/read/28742870/factors-contributing-to-food-insecurity-among-women-living-with-hiv-in-the-dominican-republic-a-qualitative-study
#12
Kathryn P Derose, Denise D Payán, María Altagracia Fulcar, Sergio Terrero, Ramón Acevedo, Hugo Farías, Kartika Palar
BACKGROUND: Food insecurity contributes to poor health outcomes among people living with HIV. In Latin America and the Caribbean, structural factors such as poverty, stigma, and inequality disproportionately affect women and may fuel both the HIV epidemic and food insecurity. METHODS: We examined factors contributing to food insecurity among women living with HIV (WLHIV) in the Dominican Republic (DR). Data collection included in-depth, semi-structured interviews in 2013 with 30 WLHIV with indications of food insecurity who resided in urban or peri-urban areas and were recruited from local HIV clinics...
2017: PloS One
https://www.readbyqxmd.com/read/28711296/anaerobic-digestion-of-food-waste-a-review-focusing-on-process-stability
#13
REVIEW
Lei Li, Xuya Peng, Xiaoming Wang, Di Wu
Food waste (FW) is rich in biomass energy, and increasing numbers of national programs are being established to recover energy from FW using anaerobic digestion (AD). However process instability is a common operational issue for AD of FW. Process monitoring and control as well as microbial management can be used to control instability and increase the energy conversion efficiency of anaerobic digesters. Here, we review research progress related to these methods and identify existing limitations to efficient AD; recommendations for future research are also discussed...
July 6, 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28704674/urban-growth-and-water-access-in-sub-saharan-africa-progress-challenges-and-emerging-research-directions
#14
REVIEW
S Dos Santos, E A Adams, G Neville, Y Wada, A de Sherbinin, E Mullin Bernhardt, S B Adamo
For the next decade, the global water crisis remains the risk of highest concern, and ranks ahead of climate change, extreme weather events, food crises and social instability. Across the globe, nearly one in ten people is without access to an improved drinking water source. Least Developed Countries (LDCs) especially in sub-Saharan Africa (SSA) are the most affected, having disproportionately more of the global population without access to clean water than other major regions. Population growth, changing lifestyles, increasing pollution and accelerating urbanization will continue to widen the gap between the demand for water and available supply especially in urban areas, and disproportionately affect informal settlements, where the majority of SSA's urban population resides...
December 31, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28699761/comparison-of-intermolecular-forces-in-anhydrous-sorbitol-and-solvent-cocrystals
#15
Teresa M Dierks, Timothy M Korter
The hygroscopicity of solid sorbitol is important for its utilization as a sweetener in the pharmaceutical and food industries. The molecular foundations of sorbitol hydration characteristics are explored here using two solvated cocrystals, sorbitol-water and sorbitol-pyridine. In this work, solid-state density functional theory and terahertz time-domain spectroscopy were used to evaluate the relative stabilities of these cocrystals as compared to anhydrous sorbitol in terms of conformational and cohesive energies...
July 21, 2017: Journal of Physical Chemistry. A
https://www.readbyqxmd.com/read/28698541/ataxia-telangiectasia-in-siblings-oral-motor-and-swallowing-characterization
#16
Silmara Rondon-Melo, Isabel Junqueira de Almeida, Claudia Regina Furquim de Andrade, Fernanda Chiarion Sassi, Daniela Regina Molini-Avejonas
BACKGROUND The body of literature on oral motor and swallowing disorders in patients with ataxia telangiectasia (AT) is limited. CASE REPORT The purpose of this study was to characterize oral motor and swallowing disorders in two siblings with AT, based on oral motor and swallowing assessments. Specific procedures were applied for oral motor and swallowing assessments and both patients underwent videofluoroscopy (VFS). Case 1 presented vocal instability, change in postural control during feeding; food retention in oral cavity; slower oral transit time; and multiple swallowing (signs for solid and liquid)...
July 12, 2017: American Journal of Case Reports
https://www.readbyqxmd.com/read/28672063/low-weight-gain-at-the-start-of-a-family-based-intervention-for-adolescent-girls-with-restrictive-eating-disorders-predicted-emergency-hospital-admission
#17
Ingemar Swenne, Helena Salonen Ros
AIM: This study examined predictors of emergency hospitalisation of adolescent girls with restrictive eating disorders and weight loss treated by a family-based intervention programme. METHODS: We studied 339 girls aged 10-17 years treated in a specialist unit at Uppsala University Children's Hospital, Sweden, from August 2010 to December 2015. Historical weight data were obtained from school health services and other weight data were determined at presentation...
July 3, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/28665949/possible-mechanisms-of-pollination-failure-in-hybrid-carrot-seed-and-implications-for-industry-in-a-changing-climate
#18
Melissa Ann Broussard, Flore Mas, Brad Howlett, David Pattemore, Jason M Tylianakis
Approximately one-third of our food globally comes from insect-pollinated crops. The dependence on pollinators has been linked to yield instability, which could potentially become worse in a changing climate. Insect-pollinated crops produced via hybrid breeding (20% of fruit and vegetable production globally) are especially at risk as they are even more reliant on pollinators than open-pollinated plants. We already observe a wide range of fruit and seed yields between different cultivars of the same crop species, and it is unknown how existing variation will be affected in a changing climate...
2017: PloS One
https://www.readbyqxmd.com/read/28646407/associations-of-red-and-processed-meat-intake-with-major-molecular-pathological-features-of-colorectal-cancer
#19
Prudence R Carr, Lina Jansen, Stefanie Bienert, Wilfried Roth, Esther Herpel, Matthias Kloor, Hendrik Bläker, Jenny Chang-Claude, Hermann Brenner, Michael Hoffmeister
Red and processed meat is an established risk factor for colorectal cancer (CRC). However, exact mechanisms to explain the associations remain unclear. Few studies have investigated the association with CRC by molecular tumor features, which could provide relevant information on associated molecular pathways. In this population-based case-control study from Germany (DACHS), 2449 cases and 2479 controls provided information on risk factors of CRC and completed a food frequency questionnaire. Multivariable logistic regression was used to estimate odds ratios (ORs) and 95% confidence intervals (CI) for the associations between meat intake and risk of CRC by molecular pathologic features and specific subtypes...
May 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28633456/feeding-during-dialysis-risks-and-uncertainties
#20
Rajiv Agarwal, Panagiotis Georgianos
Allowing dialysis patients to eat during the treatment is controversial. It is, therefore, no surprise that practices and policies with respect to intradialytic food consumption vary considerably from unit to unit and from country to country. Those who defend the position of feeding during dialysis reason that intradialytic meals offer a supervised and effective therapy for protein-energy wasting. Those who take the opposite view argue that intradialytic food intake should be avoided for the following three reasons...
June 19, 2017: Nephrology, Dialysis, Transplantation
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