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Valentin Goede, Reinhard Stauder
Multidisciplinary care is believed to provide benefits to patients with cancer. Tumor board conferences as well aspalliative care or psycho-oncological services have not only become common in oncology, but also in hematology clinics dedicated to the treatment of hematological cancers. Malignant hematological diseases are highly prevalent among older persons. Demographic changes in many countries worldwide are prompting the integration of geriatric principles, methodology, and expertise into existing procedures and infrastructure of multidisciplinary care in hematology clinics...
September 18, 2018: Journal of Geriatric Oncology
Jane Alana Parkin Kullmann, Susan Hayes, Roger Pamphlett
Psychological stress has been suggested to be relevant to the pathogenesis of neurodegenerative disorders, possibly via the generation of oxygen free radicals. We therefore sought to determine whether people with amyotrophic lateral sclerosis (ALS) had been subjected to more potentially stressful life events or occupations than controls, and whether they had differences in resilience or trait anxiety that would moderate their responses to these stressors. An online anonymous multilingual questionnaire was used to collect data on significant life events from people with and without ALS, using items from a modified Social Readjustment Rating Scale and from self-described significant events, which were combined to create a Life Events Inventory...
2018: PloS One
Clotilde Allavena, Matthieu Hanf, David Rey, Claudine Duvivier, Firouze BaniSadr, Isabelle Poizot-Martin, Christine Jacomet, Pascal Pugliese, Pierre Delobel, Christine Katlama, Véronique Joly, Christian Chidiac, Nathalie Dournon, Dominique Merrien, Thierry May, Jacques Reynes, Amandine Gagneux-Brunon, Catherine Chirouze, Thomas Huleux, André Cabié, François Raffi
As HIV-infected adults on successful antiretroviral therapy (ART) are expected to have close to normal lifespans, they will increasingly develop age-related comorbidities. The objective of this cross-sectional study was to compare in the French Dat'AIDS cohort, the HIV geriatric population, aged 75 years and over, to the elderly one, aged from 50 to 74 years. As of Dec 2015, 16,436 subjects (43.8% of the French Dat'AIDS cohort) were aged from 50 to 74 (elderly group) and 572 subjects (1.5%) were aged 75 and over (geriatric group)...
2018: PloS One
Sophie Pilleron, Isabelle Soerjomataram, Hadrien Charvat, Eric Chokunonga, Nontuthuzelo I M Somdyala, Henry Wabinga, Ann Korir, Freddie Bray, Ahmedin Jemal, D Maxwell Parkin
Although the countries of Sub-Sharan Africa represent among the most rapidly growing and aging populations worldwide, no previous studies have examined the cancer patterns in older adults in the region as a means to inform cancer policies. Using data from Cancer Incidence in Five Continents, we describe recent patterns and trends in incidence rates for the major cancer sites in adults aged ≥60 years and in people aged 0-59 for comparison in four selected population-based cancer registries in Kenya (Nairobi), the Republic of South Africa (Eastern Cape Province), Uganda (Kyadondo country), and Zimbabwe (Harare blacks)...
September 21, 2018: International Journal of Cancer. Journal International du Cancer
Tian Xie, Binbin Ma, Yingjuan Li, Jihong Zou, Xiaodong Qiu, Hui Chen, Chen Wang, Yunfeng Rui
Objective: To summarize the latest developments in the enhanced recovery after surgery (ERAS) in the geriatric hip fractures and its perioperative therapy management. Methods: The recent original literature on the ERAS in the geriatric hip fractures were extensively reviewed, illustrating the concepts and properties of the ERAS in the geriatric hip fractures. Results: It has been considered to be associated with the decreased postoperative morbidity, reduced hospital length of stay, and cost savings to implement ERAS protocols, including multimodal analgesia, inflammation control, intravenous fluid therapy, early mobilization, psychological counseling, and so on, in the perioperative (emergency, preoperative, intraoperative, postoperative) management of the geriatric hip fractures...
August 1, 2018: Chinese Journal of Reparative and Reconstructive Surgery
Tsuyoshi Okamura, Chiaki Ura, Fumiko Miyamae, Mika Sugiyama, Hiroki Inagaki, Edahiro Ayako, Murayama Hiroshi, Keiko Motokawa, Shuichi Awata
AIM: Late-life depression is identified less often by general practitioners than depression in younger adults, but failure to have late-life depression recognized in a primary care setting can have fatal consequences. The aim of the present study was to examine the prevalence of depressed mood and loss of interest, and identify associated factors among community-dwelling older adults in a large-scale study. METHODS: A questionnaire was mailed to all residents (n = 132 005) aged ≥65 years in one Tokyo district...
September 20, 2018: Geriatrics & Gerontology International
Talia Herman, Shirley Shema-Shiratzky, Liraz Arie, Nir Giladi, Jeffrey M Hausdorff
INTRODUCTION: Prospective studies identifying predictors of freezing of gait (FOG) in Parkinson's disease (PD) are limited. We aim to explore which symptoms are associated with future development of FOG in non-freezers. METHODS: Fifty-seven PD patients without FOG at baseline were re-evaluated after a mean of five years. At baseline, disease severity [Unified Parkinson's Disease Rating Scale (MDS-UPDRS)], gait under single and dual-tasking, balance, cognition and other non-motor symptoms were assessed...
September 11, 2018: Parkinsonism & related Disorders
Soon Eu Chong, Rhendra Hardy Mohamad Zaini, Wan Fadzlina, Al Jadidi Sulaiman, Vivekananda Gunasekaran
Postlaparotomy management for elderly patients with underlying comorbidities is always a challenge because of poor cardiorespiratory reserves and prolonged effect of anesthetic drugs. For these reasons, such patients usually require intensive care unit (ICU) admission in the postoperative period. We report a case of an 85-year-old chronic smoker with controlled diabetes mellitus who needed an emergency laparotomy for a perforated gastric ulcer. Unfortunately, there was a shortage of ICU backup. With the successful conduct of an early surgery using combined general and regional anesthesia, the use of sugammadex (Bridion, Merck Sharp & Dohme Corp, Oss, the Netherlands) as a reversal agent, a skilled surgeon, and good postanesthesia care, the patient did not require ICU admission...
October 2018: Journal of Perianesthesia Nursing: Official Journal of the American Society of PeriAnesthesia Nurses
Simon Friedrich Boettger, Bjoern Angersbach, Christiane Nicola Klimek, Ana Lemos Monteiro Wanderley, Azim Shaibekov, Lars Sieske, Baigang Wang, Matthias Zuchowski, Rainer Wirth, Maryam Pourhassan
BACKGROUND: Vitamin D deficiency is known to be highly prevalent in older persons. However, the prevalence in the subgroup of frail older hospitalized patients is not clear. We sought to investigate the prevalence and predictors of vitamin D deficiency in frail older hospitalized patients. METHODS: 217 consecutively geriatric hospitalized patients with routine measurements of 25-hydroxyvitamin D [25 (OH)D] at hospital admission were analyzed retrospectively, including information of previous vitamin D supplementation and the geriatric assessment...
September 20, 2018: BMC Geriatrics
R Voumard, E Rubli Truchard, L Benaroyo, G D Borasio, C Büla, R J Jox
In aging societies, the last phase of people's lives changes profoundly, challenging traditional care provision in geriatric medicine and palliative care. Both specialties have to collaborate closely and geriatric palliative care (GPC) should be conceptualized as an interdisciplinary field of care and research based on the synergies of the two and an ethics of care.Major challenges characterizing the emerging field of GPC concern (1) the development of methodologically creative and ethically sound research to promote evidence-based care and teaching; (2) the promotion of responsible care and treatment decision making in the face of multiple complicating factors related to decisional capacity, communication and behavioural problems, extended disease trajectories and complex social contexts; (3) the implementation of coordinated, continuous care despite the increasing fragmentation, sectorization and specialization in health care...
September 20, 2018: BMC Geriatrics
Byoung-Geun Han, Jun Young Lee, Jae-Seok Kim, Jae-Won Yang
BACKGROUND: Fluid overload and protein-energy wasting (PEW) are common in patients with end-stage renal disease (ESRD) and lead to a poor prognosis. We aimed to evaluate the volume and nutritional status of ESRD patients and to determine the clinical significance of phase angle (PhA). METHODS: This study was a cross-sectional comparison of bioimpedance spectroscopy (BIS) findings in patients with non-dialysis chronic kidney disease (CKD) stage 5 (CKD5-ND, N = 80) and age/sex-matched peritoneal dialysis patients (PD, N = 80)...
September 19, 2018: Nutrients
Kazuhiro Migita, Sohei Matsumoto, Kohei Wakatsuki, Masahiro Ito, Tomohiro Kunishige, Hiroshi Nakade, Masayuki Sho
The aim of this study was to investigate the impact of the geriatric nutritional risk index (GNRI) on the long-term outcomes in 137 esophageal squamous cell carcinoma (ESCC) patients who underwent curative esophagectomy. The GNRI was calculated from the serum albumin value and the body weight. The cutoff value of the GNRI was set at 98. A multivariate analysis was performed to identify prognostic factors for the overall survival (OS). The mean preoperative GNRI was 99.9 ± 7.8. Forty-five (32.8%) patients had a GNRI of <98...
September 20, 2018: Nutrition and Cancer
Jessica C Chun, Susan J Appel, Steven Simmons
BACKGROUND AND PURPOSE: The elderly population is expected to double by 2050 with falls and hospitalizations due to adverse drug events having a major effect on health and quality of life. With the release of the revised 2015 American Geriatrics Society (AGS) Beers criteria, usage of potentially inappropriate medications (PIMs) should be studied to determine their effect on falls and hospitalizations in frail populations such as those in assisted living facilities. METHODS: This quality improvement project used a retrospective chart review on residents from a purposive sample of two assisted living facilities in Northern Virginia...
September 18, 2018: Journal of the American Association of Nurse Practitioners
Evelyn Leuzinger, Beate Poblete, Christoph J Konrad, Damon Hansen
BACKGROUND: Transfusion guidelines have become increasingly restrictive. We investigated actual transfusion practices in geriatric hip fracture patients, why they differ from current guidelines and how this affects outcome. OBJECTIVES: The primary aim was to examine transfusion timing, evaluate how many red blood cell (RBC) transfusions are in keeping with and how this affects morbidity (infection, cardiac events and delirium), mortality and length of stay (LOS)...
September 17, 2018: European Journal of Anaesthesiology
Umesh Kapil, Ritika Khandelwal, Lakshmy Ramakrishnan, Preetika Khenduja, Aakriti Gupta, Neha Sareen, Ravindra Mohan Pandey, Hem Chandra Sati, Ravi Shankar Belwal
Introduction: Metabolic syndrome (MetS) is responsible for 2.5-fold increase in cardiovascular mortality and a 5-fold higher risk of developing diabetes. Materials and Methods: A community-based cross-sectional study was conducted during 2015-2016 in District Nainital. A list of all villages was developed. From this list, thirty villages were identified using population proportionate to size sampling method. From each village, thirty geriatric subjects (GSs) were selected...
July 2018: Journal of Family Medicine and Primary Care
Rizky Abdulah, Widya N Insani, Dika P Destiani, Nurul Rohmaniasari, Nithya D Mohenathas, Melisa I Barliana
Background: The geriatric population is particularly vulnerable to being prescribed potentially inappropriate medication (PIM); however, the prevalence of this occurrence remains poorly investigated in Indonesia. Thus in this research, we focused on investigating the prevalence and predictors of PIM among the Indonesian geriatric population in a primary health care setting. Methods: A retrospective observational study was conducted in 25 primary health care facilities in Karawang District, Indonesia...
2018: Therapeutics and Clinical Risk Management
Hui Wang, Shan Hai, Yixin Liu, Li Cao, Ying Liu, Ping Liu, Jianghua Zhou, Ying Yang, Birong Dong
Purpose: The aim of this study was to assess the prevalence of sarcopenia and depressive symptoms and estimate the association between them in elderly Chinese community-dwelling individuals. Patients and methods: A total of 948 elderly Chinese community-dwelling individuals were recruited through leaflets and posters from three communities in Chengdu, and 865 participants were analyzed in this cross-sectional study. Muscle mass was measured using the bioimpedance analysis, handgrip strength was measured with a handheld dynamometer, and physical performance was assessed via usual gait speed on a 6 m course...
2018: Clinical Interventions in Aging
Cyrus Ahalt, Irena Stijacic-Cenzer, Bruce L Miller, Howard J Rosen, Deborah E Barnes, Brie A Williams
OBJECTIVES: To determine prevalence of, and outcomes associated with, a positive screen for cognitive impairment in older adults in jail. DESIGN: Combined data from cross-sectional (n=185 participants) and longitudinal (n=125 participants) studies. SETTING: Urban county jail. PARTICIPANTS: Individuals in jail aged 55 and older (N = 310; mean age 59, range 55-80). Inclusion of individuals aged 55 and older is justified because the criminal justice system defines "geriatric prisoners" as those aged 55 and older...
September 19, 2018: Journal of the American Geriatrics Society
Bina Kumari Mehta, Kaushal Kumar Singh, Sugato Banerjee
Type 2 Diabetes (T2D) associated cognitive impairment is highly prevalent especially among the geriatric population. Here we investigate the role of exercise in T2D associated cognitive decline in rats. T2D was induced using high fat diet (15 days) followed by low dose STZ (25mg/kg). The T2D animals were subjected to aerobic exercise on running wheel for 6 weeks. Effect of aerobic exercise on cognitive performance of T2D animals was measured using step down and transfer latency tests. This was followed by measurement of reduced glutathione levels in corticohippocampal lysates...
September 19, 2018: International Journal of Neuroscience
Armin Shahrokni, Koshy Alexander, Tanya M Wildes, Martine T E Puts
The majority of patients with cancer are older adults. A comprehensive geriatric assessment (CGA) will help the clinical team identify underlying medical and functional status issues that can affect cancer treatment delivery, cancer prognosis, and treatment tolerability. The CGA, as well as more abbreviated assessments and geriatric screening tools, can aid in the treatment decision-making process through improved individualized prediction of mortality, toxicity of cancer therapy, and postoperative complications and can also help clinicians develop an integrated care plan for the older adult with cancer...
May 23, 2018: American Society of Clinical Oncology Educational Book
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