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https://www.readbyqxmd.com/read/29782610/castration-induces-satellite-cell-activation-that-contributes-to-skeletal-muscle-maintenance
#1
Alanna Klose, Wenxuan Liu, Nicole D Paris, Sophie Forman, John J Krolewski, Kent L Nastiuk, Joe V Chakkalakal
Background: Sarcopenia, the age-related loss of skeletal muscle, is a side effect of androgen deprivation therapy (ADT) for prostate cancer patients. Resident stem cells of skeletal muscle, satellite cells (SCs), are an essential source of progenitors for the growth and regeneration of skeletal muscle. Decreased androgen signaling and deficits in the number and function of SCs are features of aging. Although androgen signaling is known to regulate skeletal muscle, the cellular basis for ADT-induced exacerbation of sarcopenia is unknown...
2018: JCSM Rapid Commun
https://www.readbyqxmd.com/read/29782606/-68-ga-psma-and-11-c-choline-comparison-using-a-tri-modality-pet-ct-mri-3-0-t-system-with-a-dedicated-shuttle
#2
Omar Alonso, Gerardo Dos Santos, Margarita García Fontes, Henia Balter, Henry Engler
Background: The aim of this study was to prospectively compare the detection rate of 68 Ga-PSMA versus 11 C-Choline in men with prostate cancer with biochemical recurrence and to demonstrate the added value of a tri-modality PET/CT-MRI system. Methods: We analysed 36 patients who underwent both 11 C-Choline PET/CT and 68 Ga-PSMA PET/CT scanning within a time window of 1-2 weeks. Additionally, for the 68 Ga-PSMA scan, we used a PET/CT-MRI (3.0 T) system with a dedicated shuttle, acquiring MRI images of the pelvis...
2018: European journal of hybrid imaging
https://www.readbyqxmd.com/read/29782499/tgf%C3%AE-signaling-limits-lineage-plasticity-in-prostate-cancer
#3
Yi Hao, Glen A Bjerke, Karolina Pietrzak, Tiffany A Melhuish, Yu Han, Stephen D Turner, Henry F Frierson, David Wotton
Although treatment options for localized prostate cancer (CaP) are initially effective, the five-year survival for metastatic CaP is below 30%. Mutation or deletion of the PTEN tumor suppressor is a frequent event in metastatic CaP, and inactivation of the transforming growth factor (TGF) ß signaling pathway is associated with more advanced disease. We previously demonstrated that mouse models of CaP based on inactivation of Pten and the TGFß type II receptor (Tgfbr2) rapidly become invasive and metastatic...
May 21, 2018: PLoS Genetics
https://www.readbyqxmd.com/read/29782310/putative-gonadotropin-releasing-hormone-agonist-therapy-and-dementia-an-application-of-medicare-hospitalization-claims-data
#4
Mark A Smith, Richard L Bowen, Richard Q Nguyen, George Perry, Craig S Atwood, Alfred A Rimm
BACKGROUND: Estrogen and hormone replacement therapies to reduce Alzheimer's disease (AD) have yielded conflicting results. However, this study proposes that the well-characterized increase in serum gonadotropins following menopause or andropause are accountable for the increased risk of developing AD among the elderly population. OBJECTIVE: To determine the role of gonadotropins in the development of AD and investigate gonadotropin-releasing hormone (GnRH) agonist therapy as a potential preventative and/or disease-modifying approach to AD management...
May 16, 2018: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/29782208/optimal-radical-therapy-for-localized-prostate-cancer-recreation-of-the-self-fulfilling-prophecy-with-combination-brachytherapy
#5
Daniel E Spratt, Peter R Carroll
No abstract text is available yet for this article.
May 21, 2018: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/29781707/associations-of-whole-and-refined-grain-intakes-with-adiposity-related-cancer-risk-in-the-framingham-offspring-cohort-1991-2013
#6
Nour Makarem, Elisa V Bandera, Yong Lin, Nicola M McKeown, Richard B Hayes, Niyati Parekh
Case-control studies suggest that higher whole grain and lower refined grain intakes are associated with reduced cancer risk, but longitudinal evidence is limited. The objective of this prospective cohort study is to evaluate associations between whole and refined grains and their food sources in relation to adiposity-related cancer risk. Participants were adults from the Framingham Offspring cohort (N = 3,184; ≥18 yr). Diet, measured using a food frequency questionnaire, medical and lifestyle data were collected at exam 5 (1991-95)...
May 21, 2018: Nutrition and Cancer
https://www.readbyqxmd.com/read/29781343/issues-and-promises-of-bevacizumab-in-prostate-cancer-treatment
#7
Vittore Cereda, Vincenzo Formica, Mario Roselli
There is general agreement that increased angiogenesis is an important factor in determining prostate cancer development and prognosis. Vascular Endothelial Growth Factor (VEGF) is thought to play a primary role in the molecular events that lead to prostate cancer progression, from androgen-dependency to castration-resistance until dissemination to the skeleton. Bevacizumab is a recombinant anti-VEGF monoclonal antibody that has exhibited clinical activity in different cancer types. Areas covered: In this review we summarize the data of clinical trials, investigating the effects of bevacizumab in prostate cancer patients...
May 21, 2018: Expert Opinion on Biological Therapy
https://www.readbyqxmd.com/read/29781117/psa-screening-prostate-biopsy-and-treatment-of-prostate-cancer-in-the-years-surrounding-the-uspstf-recommendation-against-prostate-cancer-screening
#8
James T Kearns, Sarah K Holt, Jonathan L Wright, Daniel W Lin, Paul H Lange, John L Gore
BACKGROUND: The 2012 United States Preventive Services Task Force recommendation against screening for prostate cancer has impacted rates of prostate-specific antigen (PSA) screening and appears to be associated with declining prostate cancer incidence. Our objective was to characterize health care utilization that may explain these observed trends. METHODS: MarketScan claims, which capture >30 million privately insured patients in the United States, were queried for all men aged 40-64 years for the years 2008-2014...
May 21, 2018: Cancer
https://www.readbyqxmd.com/read/29781113/moving-toward-a-more-rational-evidence-based-approach-to-psa-screening-diagnosis-and-treatment-of-prostate-cancer
#9
EDITORIAL
Christopher P Filson
No abstract text is available yet for this article.
May 21, 2018: Cancer
https://www.readbyqxmd.com/read/29780973/case-report-transection-of-radial-arterial-catheter-requiring-surgical-intervention
#10
Luis Tollinche, Jacob Jackson, Melvin La, Dawn Desiderio, Cindy Yeoh
We report a case in which a radial arterial line was placed prior to induction of general anaesthesia in a 76 year old male with prostate cancer and multiple co-morbidities who presented for thoracoscopic resection of a right lower lobe carcinoid lung tumor. The patient's intra-operative course was complicated by acute blood loss requiring conversion to an open procedure. A subsequent injury to the superior vena cava resulted in the need for immediate re-exploration at the conclusion of surgery. While the arterial line was still indicated in this patient's postoperative course in the ICU, malfunction on post-operative day one resulted in removal of the catheter...
2018: Journal of Intensive and Critical Care
https://www.readbyqxmd.com/read/29780878/microfluidics-in-malignant-glioma-research-and-precision-medicine
#11
Meghan Logun, Wujun Zhao, Leidong Mao, Lohitash Karumbaiah
Glioblastoma multiforme (GBM) is an aggressive form of brain cancer that has no effective treatments and a prognosis of only 12-15 months. Microfluidic technologies deliver microscale control of fluids and cells, and have aided cancer therapy as point-of-care devices for the diagnosis of breast and prostate cancers. However, a few microfluidic devices are developed to study malignant glioma. The ability of these platforms to accurately replicate the complex microenvironmental and extracellular conditions prevailing in the brain and facilitate the measurement of biological phenomena with high resolution and in a high-throughput manner could prove useful for studying glioma progression...
May 2018: Advanced Biosystems
https://www.readbyqxmd.com/read/29780751/metastatic-castration-resistant-prostate-cancer-and-the-challenge-of-a-patient-with-chronic-kidney-disease-in-hemodialysis
#12
Joana Simões, Isabel Augusto, Sara Meireles, Lurdes Vendeira, Carlos Silva
At a time when the population shows increasing longevity, entities such as cancer and chronic kidney disease (CKD) are more frequently connected. In the United States, approximately 6% of the patients on hemodialysis have cancer. The challenge to manage oncologic patients with CKD in a hemodialytic program represents a great shortage of available information on the choice of the best drug, timing, dosage adjustments, dialysis method, and treatment safety. We present the case of a patient with prostate cancer and terminal CKD in hemodialysis, and the treatment sequence after the development of resistance to hormonal blockade therapy, which included docetaxel, enzalutamide, and radium-223...
April 2018: Autopsy & Case Reports
https://www.readbyqxmd.com/read/29780650/metastatic-prostate-cancer-manifesting-as-cholestatic-jaundice-a-case-report-and-review-of-the-literature
#13
Deepak Ravindranathan, Emilie Elise Hitron, Greta Anne Russler, Yue Xue, Mehmet Asim Bilen
A paraneoplastic syndrome can often present as the first manifestation of an underlying malignancy. We report a patient who presented with cholestatic jaundice as a paraneoplastic syndrome from his newly diagnosed metastatic prostate cancer. He received initial treatment with androgen deprivation therapy followed by six cycles of docetaxel resulting in resolution of his cholestatic process, normalization of liver enzyme levels, and excellent biochemical and radiographic response. To the best of our knowledge, this is the first reported case of metastatic prostate cancer with cholestatic jaundice as a paraneoplastic phenomenon to be safely treated with androgen deprivation therapy and upfront docetaxel, reflecting the latest shift in the treatment of metastatic prostate cancer...
2018: Case Reports in Oncological Medicine
https://www.readbyqxmd.com/read/29780357/altered-circadian-rhythms-and-breast-cancer-from-the-human-to-the-molecular-level
#14
REVIEW
Hui-Hsien Lin, Michelle E Farkas
Circadian clocks are fundamental, time-tracking systems that allow organisms to adapt to the appropriate time of day and drive many physiological and cellular processes. Altered circadian rhythms can result from night-shift work, chronic jet lag, exposure to bright lights at night, or other conditioning, and have been shown to lead to increased likelihood of cancer, metabolic and cardiovascular diseases, and immune dysregulation. In cases of cancer, worse patient prognoses and drug resistance during treatment have also been observed...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29780252/chelerythrine-induced-cell-death-through-ros-dependent-er-stress-in-human-prostate-cancer-cells
#15
Songjiang Wu, Yanying Yang, Feiping Li, Lifu Huang, Zihua Han, Guanfu Wang, Hongyuan Yu, Haiping Li
Introduction: Prostate cancer is the most common noncutaneous cancer and the second leading cause of cancer-related mortality worldwide and the third in USA in 2017. Chelerythrine (CHE), a naturalbenzo[c]phenanthridine alkaloid, formerly identified as a protein kinase C inhibitor, has also shown anticancer effect through a number of mechanisms. Herein, effect and mechanism of the CHE-induced apoptosis via reactive oxygen species (ROS)-mediated endoplasmic reticulum (ER) stress in prostate cancer cells were studied for the first time...
2018: OncoTargets and Therapy
https://www.readbyqxmd.com/read/29780113/familial-mediterranean-fever-mutations-in-a-patient-with-periodic-episodes-of-systemic-pain-deriving-from-cancer-bone-metastases
#16
Kouhei Yamashita, Kiyomi Mizugishi, Akifumi Takaori-Kondo
Familial Mediterranean fever (FMF), the most common autoinflammatory disorder, is characterized by recurrent febrile attacks and polyserositis. FMF is caused by mutations in MEFV, which encodes pyrin. In this report, we present an atypical FMF case with E148Q/L110P mutations in MEFV. The patient experienced periodic episodes of systemic pain originating from prostate cancer bone metastases. The pain attacks were prevented by continuous prophylactic therapy with colchicine. In this case, the presence of atypical FMF may have modulated the clinical manifestations of cancer bone metastases...
May 18, 2018: Internal Medicine
https://www.readbyqxmd.com/read/29779975/design-and-synthesis-of-a-series-of-bioavailable-fatty-acid-synthase-fasn-kr-domain-inhibitors-for-cancer-therapy
#17
Tianbao Lu, Carsten Schubert, Maxwell D Cummings, Gilles Bignan, Peter J Connolly, Karine Smans, Donald Ludovici, Michael H Parker, Christophe Meyer, Christian Rocaboy, Richard Alexander, Bruce Grasberger, Sabine De Breucker, Norbert Esser, Erwin Fraiponts, Ron Gilissen, Boudewijn Janssens, Danielle Peeters, Luc Van Nuffel, Peter Vermeulen, James Bischoff, Lieven Meerpoel
We designed and synthesized a new series of fatty acid synthase (FASN) inhibitors with potential utility for the treatment of cancer. Extensive SAR studies led to highly active FASN inhibitors with good cellular activity and oral bioavailability, exemplified by compound 34. Compound 34 is a potent inhibitor of human FASN (IC50  = 28 nM) that effectively inhibits proliferation of A2780 ovarian cells (IC50  = 13 nM) in lipid-reduced serum (LRS). This cellular activity can be rescued by addition of palmitate, consistent with an on-target effect...
May 8, 2018: Bioorganic & Medicinal Chemistry Letters
https://www.readbyqxmd.com/read/29779925/the-application-of-p2psa-and-prostate-health-index-in-prostate-cancer-detection-a-prospective-cohort-in-a-tertiary-medical-center
#18
Yung-Ting Cheng, Chih-Hung Chiang, Yeong-Shiau Pu, Shih Ping Liu, Yu-Chuang Lu, Yi-Kai Chang, Hong-Chiang Chang, Kuo-How Huang, Yuan-Ju Lee, Po-Ming Chow, Shih-Chun Hung, Chao-Yuan Huang
BACKGROUND/PURPOSE: Prostate specific antigen (PSA) with low specificity that causes unnecessary prostate biopsies increases clinical morbidities, psychological stress, and medical expenses. We aimed to test the accuracy and cutoff value of Prostate Health Index (PHI) in men for prostate cancer detection. METHODS: We prospectively enrolled 213 men who underwent prostate biopsy with PSA≦10 ng/ml or abnormal findings on digital rectal examination. Total PSA (tPSA), free PSA (fPSA) and p2PSA levels were measured by serum samples before prostate biopsy...
May 17, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29779860/time-for-a-radical-change-to-active-surveillance-for-prostate-cancer
#19
EDITORIAL
Jenny L Donovan, Freddie C Hamdy
No abstract text is available yet for this article.
May 17, 2018: European Urology
https://www.readbyqxmd.com/read/29779672/modifiable-risk-factors-to-reduce-renal-cell-carcinoma-incidence-insight-from-the-plco-trial
#20
Jonathan Gelfond, Osamah Al-Bayati, Aashish Kabra, Kevan Iffrig, Dharam Kaushik, Michael A Liss
INTRODUCTION: Identify modifiable factors contributing to renal cell carcinoma in the PCLO to target disease prevention and reduce health care costs. METHODS: The prostate, lung, colorectal, and ovarian database were queried for the primary outcome of kidney cancer. Demographics were investigated, specifically focusing on modifiable risk factors. Statistical analysis includes the Student t-test for continuous variables, chi-squared or Fisher's exact tests for dichotomous and categorical variables for bivariate analysis...
May 17, 2018: Urologic Oncology
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