keyword
MENU ▼
Read by QxMD icon Read
search

Maha

keyword
https://www.readbyqxmd.com/read/28343629/biallelic-variants-in-otud6b-cause-an-intellectual-disability-syndrome-associated-with-seizures-and-dysmorphic-features
#1
Teresa Santiago-Sim, Lindsay C Burrage, Frédéric Ebstein, Mari J Tokita, Marcus Miller, Weimin Bi, Alicia A Braxton, Jill A Rosenfeld, Maher Shahrour, Andrea Lehmann, Benjamin Cogné, Sébastien Küry, Thomas Besnard, Bertrand Isidor, Stéphane Bézieau, Isabelle Hazart, Honey Nagakura, LaDonna L Immken, Rebecca O Littlejohn, Elizabeth Roeder, Bulent Kara, Katia Hardies, Sarah Weckhuysen, Patrick May, Johannes R Lemke, Orly Elpeleg, Bassam Abu-Libdeh, Kiely N James, Jennifer L Silhavy, Mahmoud Y Issa, Maha S Zaki, Joseph G Gleeson, John R Seavitt, Mary E Dickinson, M Cecilia Ljungberg, Sara Wells, Sara J Johnson, Lydia Teboul, Christine M Eng, Yaping Yang, Peter-Michael Kloetzel, Jason D Heaney, Magdalena A Walkiewicz
Ubiquitination is a posttranslational modification that regulates many cellular processes including protein degradation, intracellular trafficking, cell signaling, and protein-protein interactions. Deubiquitinating enzymes (DUBs), which reverse the process of ubiquitination, are important regulators of the ubiquitin system. OTUD6B encodes a member of the ovarian tumor domain (OTU)-containing subfamily of deubiquitinating enzymes. Herein, we report biallelic pathogenic variants in OTUD6B in 12 individuals from 6 independent families with an intellectual disability syndrome associated with seizures and dysmorphic features...
March 21, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28340049/cardiac-troponin-i-as-a-predictor-of-mortality-in-patients-with-first-episode-acute-atrial-fibrillation
#2
Mohammad E Naffaa, Roni Nasser, Elias Manassa, Maha Younis, Zaher S Azzam, Doron Aronson
Background: Recent-onset atrial fibrillation (AF) is a frequent cause for presentation to the emergency department. Recent studies proposed that the addition of biomarker information might improve the prediction of clinical outcomes by enabling identification of patients at high risk. Aim: We aimed to examine the role of cardiac troponin I as a predictor of clinical outcome in patients with first episode acute atrial fibrillation. Design: : Patients, 18 years or older, presenting to our hospital with a primary diagnosis of first episode acute atrial fibrillation were included in this retrospective study...
March 11, 2017: QJM: Monthly Journal of the Association of Physicians
https://www.readbyqxmd.com/read/28339660/eculizumab-in-secondary-atypical-haemolytic-uraemic-syndrome
#3
Teresa Cavero, Cristina Rabasco, Antía López, Elena Román, Ana Ávila, Ángel Sevillano, Ana Huerta, Jorge Rojas-Rivera, Carolina Fuentes, Miquel Blasco, Ana Jarque, Alba García, Santiago Mendizabal, Eva Gavela, Manuel Macía, Luis F Quintana, Ana María Romera, Josefa Borrego, Emi Arjona, Mario Espinosa, José Portolés, Carolina Gracia-Iguacel, Emilio González-Parra, Pedro Aljama, Enrique Morales, Mercedes Cao, Santiago Rodríguez de Córdoba, Manuel Praga
Background.: Complement dysregulation occurs in thrombotic microangiopathies (TMAs) other than primary atypical haemolytic uraemic syndrome (aHUS). A few of these patients have been reported previously to be successfully treated with eculizumab. Methods.: We identified 29 patients with so-called secondary aHUS who had received eculizumab at 11 Spanish nephrology centres. Primary outcome was TMA resolution, defined by a normalization of platelet count (>150 × 10 9 /L) and haemoglobin, disappearance of all the markers of microangiopathic haemolytic anaemia (MAHA), and improvement of renal function, with a ≥25% reduction of serum creatinine from the onset of eculizumab administration...
February 20, 2017: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/28339340/patient-perspectives-on-language-discordance-during-healthcare-visits-findings-from-the-extremely-high-density-multicultural-state-of-qatar
#4
Huda Abdelrahim, Maha Elnashar, Amal Khidir, Amal Killawi, Maya Hammoud, Abdul Latif Al-Khal, Michael D Fetters
Reducing language and cultural barriers in healthcare are significant factors in resolving health disparities. Qatar's rapidly growing multicultural population presents new challenges to the healthcare system. The purpose of this research was to explore patients' perspectives about language discordance, and the strategies used to overcome language barriers during patients' visits. Participants were recruited and interviewed from four language groups (Arabic = 24, English = 20, Hindi = 20, and Urdu = 20), all of whom were living in Qatar and utilizing Hamad General Hospital-Outpatient Clinics as a source of their healthcare services...
March 24, 2017: Journal of Health Communication
https://www.readbyqxmd.com/read/28337586/the-role-of-fluoride-and-chlorhexidine-in-preserving-hardness-and-mineralization-of-enamel-and-cementum-after-gamma-irradiation
#5
Rowida Abdalla, Maha A Niazy, Wael E Jamil, Hala A Hazzaa, Amal A Elbatouti
The purpose of this study was to evaluate the effect of 0.05% sodium fluoride and 0.12% chlorhexidine mouthwashes on the micro-hardness of tooth enamel and cementum that was exposed to therapeutic doses of gamma radiation. Sixty extracted human teeth were divided into two groups, one was irradiated, the other was not irradiated. The two groups were further subdivided into three subgroups, which were each treated either with 0.05% sodium fluoride or with 0.12% chlorhexidine; the third subgroup served as a control...
March 23, 2017: Radiation and Environmental Biophysics
https://www.readbyqxmd.com/read/28334873/alternative-dna-structure-formation-in-the-mutagenic-human-c-myc-promoter
#6
Imee Marie A Del Mundo, Maha Zewail-Foote, Sean M Kerwin, Karen M Vasquez
Mutation 'hotspot' regions in the genome are susceptible to genetic instability, implicating them in diseases. These hotspots are not random and often co-localize with DNA sequences potentially capable of adopting alternative DNA structures (non-B DNA, e.g. H-DNA and G4-DNA), which have been identified as endogenous sources of genomic instability. There are regions that contain overlapping sequences that may form more than one non-B DNA structure. The extent to which one structure impacts the formation/stability of another, within the sequence, is not fully understood...
February 21, 2017: Nucleic Acids Research
https://www.readbyqxmd.com/read/28332073/aicardi-gouti%C3%A3-res-syndrome-unusual-neuro-radiological-manifestations
#7
Ghada M H Abdel-Salam, Mohamed S Abdel-Hamid, Shaimaa A Mohammad, Sherif F Abdel-Ghafar, Doaa R Soliman, Hala T El-Bassyouni, Laila Effat, Maha S Zaki
Aicardi-Goutières syndrome (AGS) is one of the expanding group of inherited congenital infection like syndromes. Here, we describe the detailed clinical and imaging findings of two sibs with AGS. Each shows scattered periventricular intracranial calcifications, severe global delay, seizures, microcephaly and spasticity. Interestingly, chilblains were observed in the two sisters as well as their parents and a paternal uncle. The brain MRI of the older sister showed marked ventricular dilatation as a result of unusual associated porencephalic cysts...
March 23, 2017: Metabolic Brain Disease
https://www.readbyqxmd.com/read/28325789/sex-specific-differences-in-mitochondria-biogenesis-morphology-respiratory-function-and-ros-homeostasis-in-young-mouse-heart-and-brain
#8
Abdel Rahman M Khalifa, Engy A Abdel-Rahman, Ali M Mahmoud, Mohamed H Ali, Maha Noureldin, Saber H Saber, Mahmoud Mohsen, Sameh S Ali
Sex-specific differences in mitochondrial function and free radical homeostasis are reported in the context of aging but not well-established in pathogeneses occurring early in life. Here, we examine if sex disparity in mitochondria function, morphology, and redox status starts early and hence can be implicated in sexual dimorphism in cardiac as well as neurological disorders prevalent at young age. Although mitochondrial activity in the heart did not significantly vary between sexes, female brain exhibited enhanced respiration and higher reserve capacity...
March 2017: Physiological Reports
https://www.readbyqxmd.com/read/28323334/the-emerging-role-of-homologous-recombination-repair-and-parp-inhibitors-in-genitourinary-malignancies
#9
REVIEW
Kalen J Rimar, Phuoc T Tran, Richard S Matulewicz, Maha Hussain, Joshua J Meeks
As cells age and are exposed to genotoxic stress, preservation of the genomic code requires multiple DNA repair pathways to remove single-strand or double-strand breaks. Loss of function somatic genomic aberrations or germline deficiency in genes involved in DNA repair can result in acute cell death or, after a latency period, cellular transformation. Therapeutic exploitation of DNA repair by inhibition of poly (adenosine diphosphate [ADP]) ribose polymerases (PARP), a family of enzymes involved in the repair of single-strand and in some cases double-strand breaks, has become a novel cancer treatment...
March 21, 2017: Cancer
https://www.readbyqxmd.com/read/28322163/geriatric-oriented-high-dose-nutraceutical-odts-formulation-and-physicomechanical-characterization
#10
Ahmed M Agiba, Sameh Abdel-Hamid, Maha Nasr, Ahmed S Geneidi
CONTEXT: Oral disintegrating tablets (ODTs) represent a better option than conventional tablets for geriatric population, owing to their fast onset of action and their better patient compliance. OBJECTIVE: Two principal therapeutic high-dose nutraceuticals; chondroitin sulphate and glucosamine were formulated into an oral disintegration tablet (ODT) intended for sublingual administration, and optimized to improve compliance and achieve rapid onset of action in osteoarthritis treatment...
March 20, 2017: Current Drug Delivery
https://www.readbyqxmd.com/read/28319207/posterior-prosthetic-teeth-size-selection-for-edentulous-egyptian-patients-a-radiographic-assessment
#11
Maha W Elkerdawy, Amr H Elkhadem
PURPOSE: The aim of this study was to correlate the location of the mental foramen and overlying teeth and apply these observations to posterior prosthetic teeth selection in a group of Egyptian edentulous patients. MATERIALS AND METHODS: Retrospective cone beam computed tomography data from 40 dentate and 40 edentulous patients scanned with radiopaque denture duplicates were compared in relation to mental foramen position. RESULTS: The probability of locating the mental foramen opposite the first premolar was higher in dentate patients, while finding it opposite the first molar was higher in edentulous patients...
March 20, 2017: International Journal of Prosthodontics
https://www.readbyqxmd.com/read/28318819/slow-pathway-radiofrequency-ablation-using-magnetic-navigation-a-description-of-technique-and-retrospective-case-analysis
#12
Abhishek Bhaskaran, Maha Albarri, Neil Ross, Sara Al Raisi, Rahul Samantha, Leonette Roode, Fazlur Nadri, Jeanette Ng, Stuart Thomas, Aravinda Thiagalingam, Pramesh Kovoor
BACKGROUND: The Magnetic Navigation System (MNS) catheter was shown to be stable in the presence of significant cardiac wall motion and delivered more effective lesions compared to manual control. This stability could potentially make AV junctional reentrant tachycardia (AVNRT) ablation safer. The aim of this study is to describe the method of mapping and ablation of AVNRT with MNS and 3-D electro-anatomical mapping system (CARTO, Biosense Webster, Diamond bar, CA, USA) anatomical mapping, with a view to improve the safety of ablation...
February 21, 2017: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/28318317/characterization-kinetics-and-thermodynamics-of-biosynthesized-uranium-nanoparticles-unps
#13
Mervate Aly Abostate, Youssry Saleh, Hamed Mira, Maysa Amin, Maha Al Kazindar, Basma Mahmoud Ahmed
The present study was carried out to explore the potential of the isolated bacterial strains isolated from Gabal El Sela in Eastern Dessert, Egypt for biosynthesis of uraninite nanoparticles intracellularly. The most potent bacterial strains associated (intra) with uranium nanoparticles were characterized by transmission electron microscope (TEM), Fourier transform infrared (FTIR) and Energy Dispersive X-ray (EDX). Studying factors affecting biosynthesis of uranium nanoparticles indicated that the optimum conditions were 6000 ppm uranium concentrations at pH 7...
March 20, 2017: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/28317386/hepatoprotective-effect-of-blocking-n-methyl-d-aspartate-receptors-in-male-albino-rats-exposed-to-acute-and-repeated-restraint-stress
#14
Shaimaa Nasr Amin, Ahmed Amro El-Aidi, Maha Zickri, Laila Ahmed Rashed, Sherif Sabry Hassan
Stress affects multiple organs in the body in addition to the brain including the liver. We aimed to assess the effects of blocking N-methyl-D-aspartate (NMDA) glutamate receptors by memantine on the liver in acute and repeated restraint stress. Forty two male albino rats divided into seven groups; control, Acute restraint stress (ARS), ARS+memantine, repeated restraint stress, repeated restraint +memantine and positive control groups. We measured serum iron, zinc, alanine transferase and Aspartame transferase, hepatic malondialdehyde, tumor necrosis factor-alpha (TNF-α), glutathione peroxidase, Superoxide dismutase, metallothionein content, zinc transporter ZRT/IRT-like Protein 14 mRNA expression, hepcidin expression...
March 18, 2017: Canadian Journal of Physiology and Pharmacology
https://www.readbyqxmd.com/read/28302549/can-we-better-understand-the-evolutionary-biology-of-cvd-from-analysis-of-ancestral-population-genomes
#15
Muntaser Ibrahim, Maha Osman, Emmanuel Peprah
No abstract text is available yet for this article.
March 13, 2017: Global Heart
https://www.readbyqxmd.com/read/28300460/smartphone-based-photoplethysmographic-imaging-for-heart-rate-monitoring
#16
Maha Alafeef
The purpose of this study is to make use of visible light reflected mode photoplethysmographic (PPG) imaging for heart rate (HR) monitoring via smartphones. The system uses the built-in camera feature in mobile phones to capture video from the subject's index fingertip. The video is processed, and then the PPG signal resulting from the video stream processing is used to calculate the subject's heart rate. Records from 19 subjects were used to evaluate the system's performance. The HR values obtained by the proposed method were compared with the actual HR...
March 16, 2017: Journal of Medical Engineering & Technology
https://www.readbyqxmd.com/read/28298072/the-anti-osteoporotic-and-anti-atherogenic-effects-of-alendronate-and-simvastatin-in-ovariectomized-rats-fed-high-fat-diet-a-comparative-study-of-combination-therapy-versus-monotherapy
#17
Maha Tarek Mohamed, Sally A Abuelezz, Suzi Sobhy Atalla, Lobna Fouad Abd El Aziz, Sonia Salib Gorge
AIM: Epidemiological studies suggest a possible link between osteoporosis and cardiovascular diseases. Mevalonate pathway was pointed to as a part of this link. This study was done to investigate the effects of Alendronate (Al) and Simvastatin (Sim), both act on the mevalonate pathway, on osteoporosis, dyslipidemia and atherosclerotic changes in ovariectomized (OVX) rats fed high fat diet (HFD). MAIN METHODS: 60 female albino rats were equally divided into 5 groups: control sham, OVX-HFD untreated, OVX -HFD treated with Al (3mg/kg/d) or/and Sim (6mg/kg/d)...
March 11, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28297699/value-of-microperimetry-in-detecting-early-retinal-toxicity-of-hydroxychloroquine-in-children-with-juvenile-systemic-lupus-erythematosus
#18
Maha M Youssef, Dina El-Fayoumi, Mohamed Karim Sidky, Ahmed I Hegazy, Huda Marzouk, Rasha M Eltanamly
PURPOSE: To evaluate retinal sensitivity in children who are on hydroxychloroquine (HCQ) for systemic lupus erythematosus using microperimetry and compare the results with those of the Humphrey visual field (HVF) 10-2 and spectral-domain optical coherence tomography (SD-OCT). PROCEDURE: A case-control cross-sectional study including 19 patients (less than 18 years old) on HCQ for at least 5 years. Controls were 21 normal children. Participants underwent a complete ophthalmic examination, then were investigated using HVF 10-2, SD-OCT, and microperimetry...
March 16, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/28296777/interleukin-1%C3%AE-and-interleukin-1receptor-antagonist-polymorphisms-in-egyptian-children-with-febrile-seizures-a-case-control-study
#19
Salah Al Morshedy, Hosam F Elsaadany, Hany E Ibrahim, Ashraf M Sherif, Mohsen A A Farghaly, Mayy A N Allah, Heba Abouzeid, Shaimaa S A Elashkar, Mohammed E Hamed, Manar M Fathy, Atef M Khalil, Maha A Noah, Mohamed S Hegab, Ahmed R Ahmed, Mustafa I A Hashem, Ahmed A Emam, Heba G Anany, Boshra R Ibrahim, Heba H Gawish, Rehab M Nabil, Lobna Abdel Fattah, Salah F Alsayed
Febrile seizure is the most common seizure disorder of childhood. Of the pro-inflammatory cytokines, interleukin-1 is defined as the first endogenous pyrogen.We designed this study to investigate single-nucleotide polymorphisms (SNPs) situated at positions -31 (C/T), and -511 (C/T) of interleukin-1beta (IL-1β) gene promoter and interleukin-1receptor antagonist (IL-1RA) gene variable number of tandem repeats in intron 2 (VNTR); to determine whether these polymorphisms could be a marker of susceptibility to febrile seizures in Egyptian children and we also measured the serum level of IL-1β to assess its relation to such polymorphisms...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28294441/accuracy-of-pre-operative-real-time-dynamic-transvaginal-ultrasound-sliding-sign-in-prediction-of-pelvic-adhesions-in-women-with-previous-abdominopelvic-surgery-a-prospective-multicenter-double-blinded-study
#20
Amira Ayachi, Rim Bouchahda, Sadok Derouich, Lassaad Mkaouer, Mehdi Kehila, Hassine Abouda, Badis Channoufi, Maha Bouyahia, Marouen Braham, Fethi Zhioua, Haifa Bouchahda, Mechaal Mourali
OBJECTIVE: To highlight the role of the transvaginal ultrasound sliding sign in predicting pelvic adhesions in women with a previous history of abdominopelvic surgery. METHODS: Multicenter prospective, interventional, double blinded study. Patients were examined before the laparoscopy or laparotomy, in gynaecological position, with transvaginal ultrasound (TVU) probe to assess vesico uterine pouch, uterus, ovaries, pouch of Douglas by analysing the gliding between two structures...
March 13, 2017: Ultrasound in Obstetrics & Gynecology
keyword
keyword
92984
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"