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https://www.readbyqxmd.com/read/29469772/precalcaneal-congenital-fibrolipomatous-hamartoma
#1
Dhafer Hafez, Ashjan Almasoudi, Waleed Al Assiri, Maha Alassmi, Najla A Al-Dawsari
Precalcaneal congenital fibrolipomatous hamartoma is a benign condition of infancy that is sometimes misdiagnosed due to lack of reports in the literature. Lesions usually present with painless, non-pruritic, skin colored bilateral, solitary, symmetric nodules located in the middle of the heels. The lesions gradually increase in size and then regress by the age of 2 to3 years old.
January 15, 2018: Dermatology Online Journal
https://www.readbyqxmd.com/read/29468294/behavioral-phenotyping-and-dopamine-dynamics-in-mice-with-conditional-deletion-of-the-glutamate-transporter-glt-1-in-neurons-resistance-to-the-acute-locomotor-effects-of-amphetamine
#2
Kathryn D Fischer, Alex C W Houston, Rajeev I Desai, Michelle R Doyle, Jack Bergman, Maha Mian, Rebekah Mannix, David L Sulzer, Se Joon Choi, Eugene V Mosharov, Nathaniel W Hodgson, Anita Bechtholt, Klaus A Miczek, Paul A Rosenberg
RATIONALE: GLT-1 is the major glutamate transporter in the brain and is expressed predominantly in astrocytes but is also present in excitatory axon terminals. To understand the functional significance of GLT-1 expressed in neurons, we generated a conditional GLT-1 knockout mouse and inactivated GLT-1 in neurons using Cre-recombinase expressed under the synapsin 1 promoter, (synGLT-1 KO). OBJECTIVES: Abnormalities of glutamate homeostasis have been shown to affect hippocampal-related behaviors including learning and memory as well as responses to drugs of abuse...
February 22, 2018: Psychopharmacology
https://www.readbyqxmd.com/read/29467581/tetrasomy-18p-case-report-and-review-of-literature
#3
Shahad Bawazeer, Maha Alshalan, Aziza Alkhaldi, Nasser AlAtwi, Mohammed AlBalwi, Abdulrahman Alswaid, Majid Alfadhel
Tetrasomy 18p syndrome (Online Mendelian Inheritance in Man 614290) is a very rare chromosomal disorder that is caused by the presence of isochromosome 18p, which is a supernumerary marker composed of two copies of the p arm of chromosome 18. Most tetrasomy 18p cases are de novo cases; however, familial cases have also been reported. It is characterized mainly by developmental delays, cognitive impairment, hypotonia, typical dysmorphic features, and other anomalies. Herein, we report de novo tetrasomy 18p in a 9-month-old boy with dysmorphic features, microcephaly, growth delay, hypotonia, and cerebellar and renal malformations...
2018: Application of Clinical Genetics
https://www.readbyqxmd.com/read/29464581/urinary-neutrophil-gelatinase-associated-lipocalin-ngal-and-serum-cystatin-c-measurements-for-early-diagnosis-of-acute-kidney-injury-in-children-admitted-to-picu
#4
Jameela Abdulaziz Kari, Mohamed Ahmed Shalaby, Kholoud Sofyani, Ahmad Saleh Sanad, Albaraa Fuad Ossra, Rayan Smeer Halabi, Maha Hassan Aljuhani, Wael Mohammad Toffaha, Feras Aymen Moria, Samar Sabry, Hanan AbdelAziz Ahmed, Khalid Abdulaziz Alhasan, Sara Sharief, Osama Safdar
BACKGROUND: Acute kidney injury (AKI) is common in critically ill children with significant mortality and morbidity. Serum creatinine is an insensitive and late biomarker compared to newly proposed AKI biomarkers. METHODS: Prospective study in pediatric intensive care unit (PICU) over three months to compare between serum cystatin-C (s-Cys-C) and urinary neutrophil gelatinase-associated lipocalin (uNGAL) as AKI biomarkers at multiple time points with pediatric risk, injury, failure, loss, end-stage renal disease (pRIFLE) classification in diagnosing AKI...
February 20, 2018: World Journal of Pediatrics: WJP
https://www.readbyqxmd.com/read/29460192/aberrant-expression-of-some-circulating-mirnas-in-childhood-acute-lymphoblastic-leukemia
#5
Menha Swellam, Maha Hashim, Magda Sayed Mahmoud, Amal Ramadan, Naglaa M Hassan
Acute lymphoblastic leukemia (ALL) is a heterogeneous cancer commonly affecting children due to dysregulation of miRNA expression. In the current study, authors investigated the expression profile for miRNA-125b-1 and miRNA-203 among childhood ALL. Blood samples were collected from newly diagnosed childhood ALL and healthy control children. The expression profile for candidate miRNAs was detected using quantitative RT-PCR analysis. Statistical analysis were performed using receiver operating characteristic curve (ROC) to examine the diagnostic efficacy of the two miRNA and their levels among ALL clinicopathological factors and phenotypes...
February 19, 2018: Biochemical Genetics
https://www.readbyqxmd.com/read/29458845/leptospirosis-in-human-biomarkers-in-host-immune-responses
#6
REVIEW
Chin Vk, Lee Ty, Lim Wf, Wan Shahriman Ywy, Syafinaz An, Zamberi S, Maha A
Leptospirosis remains one of the most widespread zoonotic diseases caused by spirochetes of the genus Leptospira, which accounts for high morbidity and mortality globally. Leptospiral infections are often found in tropical and subtropical regions, with people exposed to contaminated environments or animal reservoirs are at high risk of getting the infection. Leptospirosis has a wide range of clinical manifestations with non-specific signs and symptoms and often misdiagnosed with other acute febrile illnesses at early stage of infection...
March 2018: Microbiological Research
https://www.readbyqxmd.com/read/29458175/maintenance-of-hematopoietic-stem-and-progenitor-cells-in-fetal-intra-aortic-hematopoietic-clusters-by-the-sox17-notch1-hes1-axis
#7
Kiyoka Saito, Ikuo Nobuhisa, Kaho Harada, Satomi Takahashi, Maha Anani, Heiko Lickert, Masami Kanai-Azuma, Yoshiakira Kanai, Tetsuya Taga
The aorta-gonad-mesonephros region, from which definitive hematopoiesis first arises in midgestation mouse embryos, has intra-aortic hematopoietic clusters (IAHCs) containing hematopoietic stem cells (HSCs) and hematopoietic progenitor cells (HPCs). We previously reported expression of the transcription factor Sox17 in IAHCs, and overexpression of Sox17 in CD45low c-KIThigh cells comprising IAHCs maintains the formation of cell clusters and their multipotency in vitro over multiple passages. Here, we demonstrate the importance of NOTCH1 in IAHC formation and maintenance of the HSC/HPC phenotype...
February 16, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29453076/development-of-novel-synthesized-phthalazinone-based-parp-1-inhibitors-with-apoptosis-inducing-mechanism-in-lung-cancer
#8
Hadia Almahli, Elie Hadchity, Maiy Y Jaballah, Racha Daher, Hazem A Ghabbour, Maha M Kabil, Nasser S Al-Shakliah, Wagdy M Eldehna
Herein we report the synthesis of two series of 4-phenylphthalazin-1-ones 11a-i and 4- benzylphthalazin-1-ones 16a-h as anti-lung adenocarcinoma agents with potential inhibitory activity against PARP-1. All the newly synthesized phthalazinones were evaluated for their anti-proliferative activity against A549 lung carcinoma cell line. Phthalazinones 11c-i and 16b, c showed significant cytotoxic activity against A549 cells at different concentrations (0.1, 1 and 10 μM) for two time intervals (24 h and 48 h)...
February 7, 2018: Bioorganic Chemistry
https://www.readbyqxmd.com/read/29453069/combined-effect-of-copper-and-hydrodynamic-conditions-on-myriophyllum-alterniflorum-biomarkers
#9
Maha Krayem, Véronique Deluchat, Philippe Hourdin, Patrice Fondanèche, Florence Lecavelier Des Etangs, Véronique Kazpard, Christian Moesch, Pascal Labrousse
The aim of this study is to determine the combined effect of copper and hydrodynamic conditions on the response of certain biomarkers of an aquatic macrophyte, namely Myriophyllum alterniflorum. Watermilfoil biomarkers are monitored in a synthetic medium enriched or not with copper (100 μg.L -1 ) for 21 days in aquarium systems (150 L), under three hydrodynamic conditions: laminar, turbulent, and calm. The studied biomarkers are: respiratory and photosynthetic activities; concentrations of chlorophyll a, b and carotenoids; osmotic potential; hydrogen peroxide content; and growth...
February 9, 2018: Chemosphere
https://www.readbyqxmd.com/read/29448838/novel-methotrexate-soft-nanocarrier-fractional-erbium-yag-laser-combination-for-clinical-treatment-of-plaque-psoriasis
#10
Shahenda A Ramez, Mona M Soliman, Maha Fadel, Faisal Nour El-Deen, Maha Nasr, Eman R Youness, Dalea M Aboel-Fadl
Psoriasis is a commonly encountered chronic dermatological disease, presenting with inflammatory symptoms in patients. Systemic treatment of psoriasis is associated with several adverse effects, therefore the development of a customized topical treatment modality for psoriasis would be an interesting alternative to systemic delivery. The therapeutic modality explored in this article was the comparative treatment of psoriatic patients using nanoparticulated methotrexate in the form of jojoba oil-based microemulsion with or without fractional erbium YAG laser...
February 15, 2018: Artificial Cells, Nanomedicine, and Biotechnology
https://www.readbyqxmd.com/read/29447320/a-pilot-study-on-the-efficacy-of-a-treatment-algorithm-to-detoxify-dental-implant-surfaces-affected-by-peri-implantitis
#11
Paul S Rosen, Maha Qari, Stuart J Froum, Serge Dibart, L Lee Chou
This in vitro pilot study was performed to determine whether a treatment algorithm including mechanical debridement, followed by air powder abrasion with glycine, followed by citric acid conditioning with vigorous flushing of the surface with sterile water after each step, is capable of decontaminating an infected implant surface. A total of 14 dental implants that were deemed hopeless due to advanced peri-implantitis were extracted. Of these, 6 implants served as tests and had their exposed surfaces treated with the decontamination protocol, 6 served as untreated controls, and 2 were mechanically treated only, followed by rubbing the surface with sterile saline...
March 2018: International Journal of Periodontics & Restorative Dentistry
https://www.readbyqxmd.com/read/29446743/recent-advances-in-antioxidant-cosmeceutical-topical-delivery
#12
Shymaa Hatem, Maha Nasr, Seham A Elkheshen, Ahmed S Geneidi
Antioxidants are among the most important cosmeceuticals, with proven ability of inhibiting cellular damage. The topical skin administration of antioxidants is essential for minimizing skin aging and achieving better skin protection against harmful free radicals. However, their unfavorable physiochemical properties such as chemical instability, excessive hydrophilicity or lipophilicity and others could be a great obstacle against their skin promising effects as well as their delivery to deeper skin layers. These problems could all be remedied through the use of delivery carriers...
February 14, 2018: Current Drug Delivery
https://www.readbyqxmd.com/read/29446483/adenovirus-types-associated-with-severe-respiratory-diseases-a-retrospective-four-year-study-in-kuwait
#13
Wassim Chehadeh, Anfal Al-Adwani, Sonia Elezebeth John, Shaikhah Al-Dhufairi, Hessa Al-Dousari, Maha Alkhaledi, Widad Al-Nakib
Human adenovirus (HAdV) infection can result in a severe respiratory disease. The aim of this study was to identify HAdV types detected in patients hospitalized for severe respiratory illness. The study population consisted of 743 patients with severe respiratory disease admitted to four major hospitals in Kuwait between January 2013 and December 2016. Respiratory specimens were retrospectively screened for 20 respiratory viruses by real-time PCR. The HAdV hexon gene was amplified and directly sequenced, and HAdV types were identified by performing Bayesian phylogenetic analysis...
February 15, 2018: Journal of Medical Virology
https://www.readbyqxmd.com/read/29442425/effect-of-co-culture-human-endothelial-progenitor-cells-with-porcine-oocytes-during-maturation-subsequent-embryo-development-of-parthenotes-in-vitro
#14
Seok Hee Lee, Hyun Ju Oh, Min Jung Kim, Erif Maha Nugraha Setyawan, Yoo Bin Choi, Byeong Chun Lee
Human endothelial progenitor cells (EPCs) have been applied to regenerative medicine for their roles in angiogenesis as well as neovascularization, and these angiogenetic functions have beneficial effects on maturation of ovarian follicles. However, little information is available on whether EPCs on culture systems affect oocyte maturation and subsequent embryo development. Therefore, the objective of this study was to investigate the effect of EPC co-culture on porcine oocytes during in vitro maturation (IVM) and subsequent embryo development, and to examine gene expression in cumulus cells, oocytes and blastocysts...
February 14, 2018: Molecular Reproduction and Development
https://www.readbyqxmd.com/read/29436561/legionella-confirmation-in-cooling-tower-water-comparison-of-culture-real-time-pcr-and-next-generation-sequencing
#15
Maha Farhat, Raja A Shaheed, Haider H Al-Ali, Abdullah S Al-Ghamdi, Ghadeer M Al-Hamaqi, Hawraa S Maan, Zainab A Al-Mahfoodh, Hussain Z Al-Seba
OBJECTIVES: To investigate the presence of Legionella spp in cooling tower water. Legionella proliferation in cooling tower water has serious public health implications as it can be transmitted to humans via aerosols and cause Legionnaires' disease. METHODS: Samples of cooling tower water were collected from King Fahd Hospital of the University (KFHU) (Imam Abdulrahman Bin Faisal University, 2015/2016). The water samples were analyzed by a standard Legionella culture method, real-time polymerase chain reaction (RT-PCR), and 16S rRNA next-generation sequencing...
February 2018: Saudi Medical Journal
https://www.readbyqxmd.com/read/29433194/uplc-qtof-ms-profiling-of-two-psidium-species-and-the-in-vivo-hepatoprotective-activity-of-their-nano-formulated-liposomes
#16
Fatema R Saber, Ghada A Abdelbary, Maha M Salama, Dalia O Saleh, Magda M Fathy, Fathy M Soliman
Liver diseases are major health problem in Egypt influencing lifestyle and economy. The demand for nutraceutical hepatoprotective agents is crucial to ameliorate the side effects of synthetic drugs. The present study aims to evaluate antioxidant and hepatoprotective activities of extracts of Psidium guajava L. and Psidium cattleianum Sabine leaves and their nano-formulated liposomes against paracetamol-induced liver damage in rats. Secondary metabolites profile of P. guajava and P. cattleianum leaves was investigated using UPLC-PDA-ESI-qTOF-MSn...
March 2018: Food Research International
https://www.readbyqxmd.com/read/29430509/molecular-correlates-of-in-vitro-responses-to-dacomitinib-and-afatinib-in-bladder-cancer
#17
Shuzo Tamura, Yin Wang, Brendan Veeneman, Daniel Hovelson, Armand Bankhead, Luke J Broses, Guadalupe Lorenzatti Hiles, Monica Liebert, John R Rubin, Kathleen C Day, Maha Hussain, Nouri Neamati, Scott Tomlins, Philip L Palmbos, Petros Grivas, Mark L Day
Background: The HER family of proteins (EGFR, HER2, HER3 and HER4) have long been thought to be therapeutic targets for bladder cancer, but previous clinical trials targeting these proteins have been disappointing. Second generation agents may be more effective. Objective: The aim of this study was to evaluate responses to two second-generation irreversible tyrosine kinase inhibitors, dacomitinib and afatinib, in bladder cancer cell lines. Methods: Cell lines were characterized by targeted next generation DNA sequencing, RNA sequencing, western blotting and flow cytometry...
January 20, 2018: Bladder Cancer
https://www.readbyqxmd.com/read/29428597/possible-involvement-of-tetrahydrobiopterin-in-the-disturbance-of-redox-homeostasis-in-sepsis-induced-brain-dysfunction
#18
Maha Gamal, Jackline Moawad, Laila Rashid, Mary Attia Morcos, Nivin Sharawy
BACKGROUND AND AIM: Tetrahydrobiopterin (BH4) is an essential co-factor that regulates nitric oxide (NO) and reactive oxygen species (ROS) production by nitric oxidesynthases (NOS). In this study, we evaluated the effects of sepsis on BH 4 level and redox status in the brain by using the rat model of sepsis- induced by cecal ligation and puncture (CLP) and examined whether BH4 and/or acetyl-L-carnitine(ALC) could prevent the neuronal apoptosis and neurological changes induced by sepsis...
February 8, 2018: Brain Research
https://www.readbyqxmd.com/read/29426640/corrigendum-to-synthesis-and-characterization-of-new-1-hydroxy-2-pyridinethione-derivatives-their-lead-complexes-and-efficacy-in-the-treatment-of-acute-lead-poisoning-in-rats-j-trace-elem-med-biol-44-december-2017-209-217
#19
Manal H Al Khabbas, Samah A Ata, Kamal I Abu-Dari, Maha F Tutunji, Mohammad S Mubarak
No abstract text is available yet for this article.
February 7, 2018: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/29426622/atypical-hemolytic-uremic-syndrome-an-unusual-postoperative-complication
#20
S Mota, C Filipe, A L Almeida
INTRODUCTION AND OBJECTIVES: Thrombotic thrombocytopenic purpura and atypical haemolytic uremic syndrome (aHUS) are acute, rare, life-threatening thrombotic microangiopathies that require swift management. We report a case of acute microangiopathic haemolytic anaemia (MAHA) presenting in perioperative setting. CLINICAL CASE: After hepatic pericystectomy for hydatid cyst, a 46-year-old female developed MAHA, thrombocytopenia and acute renal failure in the immediate postoperative period...
February 6, 2018: Revista Española de Anestesiología y Reanimación
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