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Maha El Tantawi, Morenike O Folayan, Mohamed Mehaina, Ana Vukovic, Jorge L Castillo, Balgis O Gaffar, Arheiam Arheiam, Ola B Al-Batayneh, Arthur M Kemoli, Robert J Schroth, Gillian H M Lee
OBJECTIVES: To assess the relationship between health care system and economic factors and early childhood caries (ECC) data availability and prevalence. METHODS: We estimated ECC data for 193 United Nations countries from studies published between 2007 and 2017. We obtained other variables from the World Health Organization and the World Bank databases. We assessed association with ECC data availability by using logistic regression and with ECC prevalence by using linear regression...
June 21, 2018: American Journal of Public Health
Sara H Mokhtar, Min Joung Kim, Kylie A Magee, Pei Mun Aui, Speros Thomas, Maha M Bakhuraysah, Amani A Alrehaili, Jae Young Lee, David L Steer, Rachel Kenny, Catriona McLean, Michael F Azari, Antonis Birpanagos, Ewlina Lipiec, Philip Heraud, Bayden Wood, Steven Petratos
Alzheimer's disease (AD) is a neurodegenerative disorder characterized by accumulation of amyloid plaques and neurofibrillary tangles. Prior to the development of these characteristic pathological hallmarks of AD, anterograde axonal transport is impaired. However, the key proteins that initiate these intracellular impairments remain elusive. The collapsin response mediator protein-2 (CRMP-2) plays an integral role in kinesin-1-dependent axonal transport and there is evidence that phosphorylation of CRMP-2 releases kinesin-1...
June 2018: Neural Regeneration Research
Seda Seren, Maha Rashed Abouzaid, Claudia Eulenberg-Gustavus, Josefine Hirschfeld, Hala Soliman, Uwe Jerke, Koffi N'Guessan, Sandrine Dallet-Choisy, Adam Lesner, Conni Lauritzen, Beate Schacher, Peter Eickholz, Nikoletta Nagy, Marta Szell, Cécile Croix, Marie-Claude Viaud-Massuard, Abdullah Al Farraj Aldosari, Shivanna Ragunatha, Mostafa Ibrahim Mostafa, Francesca Giampieri, Maurizio Battino, Hélène Cornillier, Gérard Lorette, Jean-Louis Stephan, Cyril Goizet, John Pedersen, Francis Gauthier, Dieter E Jenne, Sylvain Marchand-Adam, Iain L Chapple, Ralph Kettritz, Brice Korkmaz
Membrane-bound proteinase 3 (PR3m) is the main target antigen of anti-neutrophil cytoplasmic autoantibodies (ANCA) in granulomatosis with polyangiitis (GPA). Binding of ANCA to PR3m triggers neutrophil activation with the secretion of enzymatically active  proteases, thereby contributing to vascular damage. PR3 and related proteases are activated from proforms by the lysosomal cysteine protease cathepsin C (CatC) during neutrophil maturation. We hypothesized that pharmacological inhibition of CatC provides an effective measure to reduce PR3m and has therefore implications as a novel therapeutic approach in GPA...
June 20, 2018: Journal of Biological Chemistry
Maha Jahangir, Marrium Nawaz, Fareha Jabbar, Fahad Khan, Nimra Hasnain
Atrial septal defect (ASD) is a common congenital abnormality, which accounts for 20-40% of all the adult patients with congenital heart diseases. Due to the slow velocity of shunt flow, ASD has a negligible risk for infective endocarditis (IE). However, intravenous drug abuse (IVDA) is a potential cause for IE. IE remains a diagnostic and therapeutic challenge. Our case report demonstrates the atypical presentation of IE in an ASD patient. The diagnosis was made on the basis of modified Duke criteria, and blood cultures were found out to be positive for methicillin-resistant Staphylococcus aureus (MRSA)...
April 15, 2018: Curēus
Maha A T Elsebaie, Mohamed Amgad, Ahmed Elkashash, Ahmed Saber Elgebaly, Gehad Gamal E L Ashal, Emad Shash, Zeinab Elsayed
This is the second-largest retrospective analysis addressing the controversy of whether adult rhabdomyosarcoma (RMS) should be treated with chemotherapy regimens adopted from pediatric RMS protocols or adult soft-tissue sarcoma protocols. A comprehensive database search identified 553 adults with primary non-metastatic RMS. Increasing age, intermediate-risk disease, no chemotherapy use, anthacycline-based and poor chemotherapy response were significant predictors of poor overall and progression-free survival...
June 19, 2018: Scientific Reports
Munira Borhany, Naveena Fatima, Madiha Abid, Tahir Shamsi, Maha Othman
BACKGROUND: Hemophilia is an inherited bleeding disorder. With proper treatment and self-care, persons with hemophilia can maintain an active, productive lifestyle. Hemophilia can be mild, moderate, or severe, depending on the degree of plasma clotting factor deficiency. The aim of the study was to assess the utility of ISTH-BAT in diagnosis, determining severity of the bleeding condition in newly diagnosed and known hemophilia patients, compare the bleeding score (BS) in adult and pediatric groups and investigate its association with plasma factor levels...
June 15, 2018: Transfusion and Apheresis Science
Maha Mohammed Abdel-Fattah, Basim Anwar Shehata Messiha, Ahmed Mohamed Mansour
The brain renin-angiotensin system (RAS) is considered a crucial regulator for physiological homeostasis and disease progression. We evaluated the protective effects of the angiotensin receptor blocker (ARB) telmisartan and the angiotensin-converting enzyme 2 (ACE2) activator xanthenone on experimental cerebral ischemia/reperfusion (I/R) injury. Rats were divided into a sham control, a cerebral I/R control, a standard treatment (nimodipine, 10 mg/kg/day, 15 days, p.o.), three telmisartan treatments (1, 3, and 10 mg/kg/day, 15 days, p...
June 17, 2018: Naunyn-Schmiedeberg's Archives of Pharmacology
Mai I Shahin, Joyeeta Roy, Maha Hanafi, Dongyao Wang, Urarika Luesakul, Yifeng Chai, Nongnuj Muangsin, Deena S Lasheen, Dalal A Abou El Ella, Khaled A Abouzid, Nouri Neamati
No new and effective treatments have been approved for the treatment of esophageal squamous cell carcinoma (ESCC) in the past decade. Cisplatin and 5-fluoruracil are the most commonly used drugs for this disease. In order to develop a new class of drugs effective in our ESCC phenotypic screens, we began a systematic approach to generate novel compounds based on the 2-oxo-1,2-dihydroquinoline-4-carboxamide fragment. Herein, we report on the synthesis and initial assessment of 55 new analogues in two ESCC cell lines...
May 29, 2018: European Journal of Medicinal Chemistry
Carol Yousry, Maha M Amin, Ahmed H Elshafeey, Omaima N El Gazayerly
Controlled-release multiparticulate systems of hydrophilic drugs usually suffer from poor encapsulation and rapid-release rate. In the present study, ultra-high loaded controlled release polymeric beads containing verapamil hydrochloride (VP) as hydrophilic model drug were efficiently prepared using superamphiphobic substrates aiming to improve patient compliance by reducing dosing frequency. Superamphiphobic substrates were fabricated using clean aluminum sheets etched with ammonia solution and were treated with 1...
November 2018: Drug Delivery
Joseph J Pariser, Omar E Soto-Aviles, Brandi Miller, Maha Husainat, Richard A Santucci
OBJECTIVES: To propose a simple classification system for buried penis repairs and present an analysis of perioperative data based on category. METHODS: Patients undergoing buried penis repair at a single institution were examined. Classification was as follows: Category I - Penile Unburying with Local Flap; II - Skin Graft; III - Scrotal Surgery; IV - Escutcheonectomy; V - Abdominal Panniculectomy. Complex repairs were Category III or above. Success was defined as an unburied penis without additional unburying surgery...
June 10, 2018: Urology
Raoudha Doghri, Salma Chaabouni, Yoldez Houcine, Lamia Charfi, Nadia Boujelbene, Maha Driss, Karima Mrad
The aim of the study was to investigate whether the tumor free distance (TFD), which is the distance in millimeters between the deepest point of invasion and the serosal surface, and absolute depth of invasion (DMI), the distance in millimeters between the endomyometrial junction and the deepest point of myometrial invasion, are useful in surgical staging and in predicting prognosis. The present study retrospectively analyzed 62 cases of endometrial carcinoma with complete surgical staging, carried out over a 4 and half-year period (January 2003 to June 2007)...
July 2018: Molecular and Clinical Oncology
Wei Lyu, Maha Alotaibi, O Alexander Bell, Kazuyoshi Watanabe, Robert Harniman, Benjamin M Mills, Annela M Seddon, Sarah E Rogers, Stephen M King, Wei Yan, Charl F J Faul
We present a newly developed approach to non-covalently address the packing parameter of an electroactive amphiphile. The pH-responsive reversible switching of a tetra(aniline)-based cationic amphiphile, TANI -pentyl trimethylammonium bromide ( TANI-PTAB ), between self-assembled vesicles and nanowires by acid/base chemistry in aqueous solution is used to exemplify this approach. Trifluoroacetic acid ( TFA ) was selected as a prototypical acid to form emeraldine salt (ES) state ( TANI(TFA)2 -PTAB ) vesicles for this new class of small-molecule supramolecular amphiphiles...
May 21, 2018: Chemical Science
Soheir S Abou El Ella, Maha Atef Tawfik, Wafaa Moustafa M Abo El Fotoh, Omar Ahmed M Soliman
PURPOSE: Previous studies have suggested that GABARG2 (Gamma-Aminobutyric acid type A Receptor Gamma 2 subunit) could be a gene of interest in genetic epilepsy; through possible associations with increased epilepsy susceptibility or resistance to antiepileptic drugs. The present study was designed to explore whether the GABARG2 C588 T (rs211037) genetic variant predicts susceptibility to epilepsy and pharmacoresistance among Egyptian children with Idiopathic Generalized Epilepsy (IGE)...
June 6, 2018: Seizure: the Journal of the British Epilepsy Association
Maha M AlRasheed, MennatAllah M Hefnawy, Nourhan N Elsherif, Tariq M Alhawassi, Norah O Abanmy, Nora M AlRasheed, Fulwah Y Alqahtani, Fadilah S Aleanizy, Paul Muiya, Olayan M Al-Boudari, Nduna Dzimiri
BACKGROUND: Genome-wide association studies (GWASs) have yielded a wealth of information furnishing support for the variability in genetic predisposition to disease. However, the actual impact of such findings on any particular ethnic population needs to be validated through replication studies. In the present study, we verified recent findings of a GWAS demonstrating a strong association for the cyclin-dependent kinase 4 inhibitor B (CDKN2B) genomic region with coronary artery disease (CAD)/myocardial infarction (MI) in ethnic Saudi Arabs...
June 9, 2018: Gene
Omar Al-Obeed, Mansoor-Ali Vaali-Mohammed, Wagdy M Eldehna, Khayal Al-Khayal, Amer Mahmood, Hatem A Abdel-Aziz, Ahmed Zubaidi, Ahmed Alafeefy, Maha Abdulla, Rehan Ahmad
Introduction: Colorectal cancer (CRC) is a major worldwide health problem owing to its high prevalence and mortality rate. Developments in screening, prevention, biomarker, personalized therapies and chemotherapy have improved detection and treatment. However, despite these advances, many patients with advanced metastatic tumors still succumb to the disease. New anticancer agents are needed for treating advanced stage CRC as most of the deaths occur due to cancer metastasis. A recently developed novel sulfonamide derivative 4-((2-(4-(dimethylamino) phenyl)quinazolin-4-yl)amino)benzenesulfonamide (3D) has shown potent antitumor effect; however, the mechanism underlying the antitumor effect remains unknown...
2018: OncoTargets and Therapy
Maha Jahangir, Roha Saeed Memon, Maria Noor
No abstract text is available yet for this article.
May 2018: JPMA. the Journal of the Pakistan Medical Association
Hani T Ali, Mohamed I Mosleh, Maha Shawky
BACKGROUND: The aim of this paper was to identify the most important variables that predict the intensity of postoperative pain following lower third molar surgery. METHODS: A unilateral 100 impacted lower third molar teeth were surgically removed under local anesthesia. Preoperative predictor variables were categorized as demographic, anatomic and radiographic, and operative variables. Evaluation of these variables was performed through personal data, extra and intra oral examination, and radiological examination, while the postoperative pain was recorded by the patient using a visual analogue scale...
June 2018: Minerva Stomatologica
Maha Bouzid, Erica Kintz, Paul R Hunter
BACKGROUND: Cryptosporidium infection causes gastrointestinal disease and has a worldwide distribution. The highest burden is in developing countries. OBJECTIVES: We sought to conduct a systematic review and meta-analysis to identify Cryptosporidium risk factors in Low and Middle Income countries (LMICs). METHODS: Medline Ovid and Scopus databases were searched with no restriction on year or language of publication. All references were screened independently in duplicate and were included if they presented data on at least 3 risk factors...
June 7, 2018: PLoS Neglected Tropical Diseases
A Abdelghani, M Abouda, K Adelmoulah, C Aichaouia, Nadia Ajmi, A Akad, Ines Akrout, Jamel Ammar, Zeineb Amouri, S Aouadi, Hichem Aouina, A Aounallah, S Atitallah, H Ayadi, N Ayadi, Sirine Ayadi, Saloua Azzabi, Mohamed Ali Baccar, N Bahloul, B Bdira, D Bejar, M Beji, C Belajouza, I Belhadj, Rafik Belhaja, H Ben Abdelghaffar, Jihen Ben Amar, E Ben Jemia, L Ben Mahmoud, Amani Ben Mansour, M Ben Romdhane, A Ben Saad, H Ben Saad, S Ben Saad, N Ben Salah, Nawel Ben Salem, A Ben Tkhayat, M Benzarti, Anissa Berraïes, Hamdi Besma, Hayet Bouakkez, M Bouhoula, K Boussetta, L Boussoffara, Hanene Bouzekri, A Brahem, I Brini, N Chaouech, Ilhem Charfeddine, M R Charfi, Rihab Charrad, S Chatti, R Cheikh, S Cheikh M'hamed, S Cheikh Rouhou, Hela Cherif, J Cherif, S Dabboussi, Hafaoua Daghfous, J Daghfous, Awatef Dahmouni, M Denguezli, Besma Dhahri, Joseph Djaman Allico, L Douik El Gharbi, Leila El Gharbi, S El Guedr, A El Kamel, O El Maalel, Leila Elfekih, Maha Essalah, N Fahem, R Fessi, W Fki, R Gammoudi, A Garrouch, N Ghariani, H Gharsalli, H Ghedira, Abdelmoneem Ghorbel, H Ghozzi, Najla Ghrairi, Dorra Greb, Y Gribaa, S Guedri, A Gueriani, E Guermazi, Chaima Habouria, S Hadj Hassine, S Hajjej, Bassma Hamdi, B Hamdia, Amal Hammami, S Hamouda, Agnes Hamzaoui, Kamel Hamzaoui, Hela Hassen, M Hayouni, A Hedhli, Y Houaneb Marghli, S Jdidi, S Joober, Wajih Kaabachi, I Kacem, R Kaddoussi, H Kalboussi, Nesrine Kallel, Souha Kallel, S Kammoun, Hela Kamoun, H Kchouk, W Ketata, M Khadhraoui, F Khalsi, A Khattab, Amin Khbou, Z Khessain, Z Khessari, R Khmekhem, I Khouaja, H Khouani, Z Khssairi, Eudes Kpan Sea, H Kwas, Oussema Lahmer, L Loued, Sabrine Louhaichi, B Louzir, S M'saad, S Maalej, Sarra Maazaoui, M Maoua, Donies Masmoudi, N H Mbarek, Mohamed Lamine Megdiche, N Mehiri, I Mejri, S Mhamdi, M Mjid, N Mkaouar, Z Moatemri, S Mokni, N Mrizak, Jean David N'guessan, R Nouira, Y Ouahchi, S Oujani, Sawsen Raies, Sonia Rouatbi, N Rouetbi, H Rouis, D Sakka, Mariem Salhi, M Slama, Hanen Smadhi, H Snene, N Souissi, A Tabboubi, F Tinsa, S Toujeni, G Trigui, M Triki, Fatma Tritar, Sadok Yalaoui, F Yangui, I Yangui, Chiaye Yapo-Crezoit, Haifa Zaibi, A Zaim, Ines Zayani, K Zayen, I Zendah
No abstract text is available yet for this article.
August 2017: La Tunisie Médicale
Ftoon Aljarbou, Nourah Almousa, Mohammad Bazzi, Sooad Aldaihan, Mohammed Alanazi, Othman Alharbi, Majid Almadi, Abdulrahman M Aljebreen, Nahla Ali Azzam, Maha Arafa, Abeer Aldbass, Jilani Shaik, Shaheerah Alasirri, Arjumand Warsy, Abdullah Alamri, Narasimha Reddy Parine, Ghadah Alamro
BACKGROUND: Colorectal cancer is the leading cause of cancer-related deaths in Saudi Arabia. Cancer has a multifactorial nature and can be described as a disease of altered gene expression. The profiling of gene expression has been used to identify cancer subtypes and to predict patients' responsiveness. Telomere-associated proteins that regulate telomere biology are essential molecules in cancer development. Thus, the present study examined their contributions to colorectal cancer progression in Saudi patients...
2018: PloS One
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