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Knowledge Retention

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https://www.readbyqxmd.com/read/29236035/short-communication-a-comparison-of-the-in-vitro-angiotensin-1-converting-enzyme-inhibitory-capacity-of-dairy-and-plant-protein-supplements
#1
Carlotta Giromini, Ágnes A Fekete, D Ian Givens, Antonella Baldi, Julie A Lovegrove
The consumption of supplements based on dairy or plant proteins may be associated with bioactive potential, including angiotensin-1-converting enzyme inhibitory (ACE-1i) activity, which is linked with blood pressure reduction in vivo. To gain insight into this proposed mechanism, the ACE-1i potential of protein-based supplements, including a selection of dairy (n = 10) and plant (n = 5) proteins were in vitro digested. The total digest was filtered and permeate and retentate were obtained. ACE-1i activity was measured as the ability of proteins (pre-digestion, 'gastric', permeate, and retentate) to decrease the hydrolysis of furanacroloyl-Phe-Glu-Glu (FAPGG) substrate for the ACE-1 enzyme...
December 13, 2017: Nutrients
https://www.readbyqxmd.com/read/29233440/incorporation-of-practice-testing-to-improve-knowledge-acquisition-in-a-pharmacotherapy-course
#2
Anne Graff LaDisa, Ann Biesboer
BACKGROUND AND PURPOSE: To incorporate and assess the impact of a coordinated practice testing activity on pharmacy student knowledge acquisition, retention, and perception as an effective study technique in a pharmacotherapy course. EDUCATIONAL ACTIVITY AND SETTING: Students were instructed to individually create, exchange, complete, and discuss solutions to weekly, cumulative practice tests of targeted material during the first unit of the course. Students completed surveys on their perceptions of practice testing...
July 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233327/appraising-the-role-of-the-virtual-patient-for-therapeutics-health-education
#3
REVIEW
Lyndsee Baumann-Birkbeck, Fiona Florentina, Onur Karatas, Jianbe Sun, Tingna Tang, Victor Thaung, Amelia McFarland, Nijole Bernaitis, Sohil A Khan, Gary Grant, Shailendra Anoopkumar-Dukie
BACKGROUND: Face-to-face instruction, paper-based case-studies and clinical placements remain the most commonly used teaching methods for therapeutics curricula. Presenting clinical content in a didactic manner presents challenges in engaging learners and developing their clinical reasoning skills which may be overcome by inclusion of the virtual patient (VP). Currently there is limited literature examining the use of the VP in therapeutics teaching and learning. This review aimed to determine the role of VPs in therapeutics education, specifically the impact on student experiences, performance, and clinical skills...
September 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29233276/comparison-of-long-term-knowledge-retention-in-lecture-based-versus-flipped-team-based-learning-course-delivery
#4
Catherine Taglieri, David Schnee, Lana Dvorkin Camiel, Kathy Zaiken, Amee Mistry, Stefanie Nigro, Gary Tataronis, Dhiren Patel, Susan Jacobson, Jennifer Goldman
OBJECTIVES: To determine whether team based learning (TBL) is superior to traditional lecture -based learning in confidence and knowledge retention one year later. DESIGN: A survey was administered 17 months after a completion of a required over-the-counter /self-care (OTC) course to two different cohorts of students. The survey assessed confidence and knowledge related to OTC topics. The lecture group had a traditional lecture based classroom experience; the intervention group experienced a TBL format throughout the entire course...
May 2017: Currents in Pharmacy Teaching & Learning
https://www.readbyqxmd.com/read/29232161/characterization-of-novel-missense-variants-of-serpina1-gene-causing-alpha-1-antitrypsin-deficiency
#5
Nerea Matamala, Beatriz Lara, Gema Gomez-Mariano, Selene Martínez, Diana Retana, Taiomara Fernandez, Ramona Angeles Silvestre, Irene Belmonte, Francisco Rodriguez-Frias, Marçal Vilar, Raquel Sáez, Igor Iturbe, Silvia Castillo, María Molina-Molina, Anna Texido, Gema Tirado-Conde, Jose Luis Lopez-Campos, Manuel Posada, Ignacio Blanco, Sabina Janciauskiene, Beatriz Martinez-Delgado
SERPINA1 gene is highly polymorphic, with more than one hundred variants described in databases. The SERPINA1 encodes alpha-1 antitrypsin (AAT) protein, and the severe deficiency of AAT is a major contributor to pulmonary emphysema and liver diseases. We report seven new variants in Spanish patients with AAT deficiency. All variants involved amino acid substitutions in different exons: PiSDonosti (S+Ser14Phe), PiTijarafe (Ile50Asn), PiSevilla (Ala58Asp), PiCadiz (Glu151Lys), PiTarragona (Phe227Cys), PiPuerto Real (Thr249Ala) and PiValencia (Lys328Glu)...
December 12, 2017: American Journal of Respiratory Cell and Molecular Biology
https://www.readbyqxmd.com/read/29231484/-the-ancient-clinical-application-of-umbilical-therapy-for-retention-of-urine
#6
Minglin Wang, Yuxia Ma
By collecting relevant ancient literature, with retention of urine, umbilical therapy and Shenque (CV 8) as key words, various umbilical therapies for retention of urine from the Song dynasty to Qing dynasty were retrieved and summarized. The results indicated rich knowledge of umbilical therapy was recorded in ancient literature (the Song dynasty to the Qing dynasty), including 9 kinds of therapies e.g. sticking umbilical method, ironing umbilical method, pasting umbilical method, smearing umbilical method, filling umbilical method, sealing umbilical method, covering umbilical method, dripping umbilical method and bundling umbilical method...
February 12, 2017: Zhongguo Zhen Jiu, Chinese Acupuncture & Moxibustion
https://www.readbyqxmd.com/read/29228864/multimedia-education-reduces-anxiety-in-lung-transplant-patients
#7
Sandra L Gerity, Susan G Silva, John M Reynolds, Benson Hoffman, Marilyn H Oermann
CONTEXT: A significant contribution to the success of lung transplantation is the recipient's ability to self-manage a multidrug regimen and follow complex instructions. Effective education has always been an integral component of the process of preparing patients to care for themselves post lung transplant. Impaired cognition, anxiety, and psychological distress, however, can decrease the retention of posttransplant care information provided during education sessions. OBJECTIVE: This quality improvement project evaluated whether a multimedia education method compared to standard education method improves posttransplant care knowledge, anxiety, and satisfaction with the education experience in lung transplant patients and their caregivers...
January 1, 2017: Progress in Transplantation
https://www.readbyqxmd.com/read/29214730/conceptual-and-operational-definitions-for-the-nursing-diagnosis-urinary-retention
#8
Juliana Neves da Costa, Micnéias Lacerda Botelho, Erika Christianne Marocco Duran, Elenice Valentim Carmona, Ana Railka de Souza Oliveira-Kumakura, Maria Helena Baena de Moraes Lopes
PURPOSE: To develop conceptual and operational definitions for defining characteristics and related factors for nursing diagnosis of urinary retention, as contained in Taxonomy II of NANDA-I. DATA SOURCES: Integrative literature review and elaboration of terms related to urinary retention. DATA SYNTHESIS: It includes operational and conceptual definitions of the nursing diagnosis urinary retention. CONCLUSIONS: It is necessary to review the definition of this nursing diagnosis and most of its defining characteristics and related factors...
December 7, 2017: International Journal of Nursing Knowledge
https://www.readbyqxmd.com/read/29212800/extracellular-retention-of-pdgf-b-directs-vascular-remodeling-in-mouse-hypoxia-induced-pulmonary-hypertension
#9
Philip Tannenberg, Ya-Ting Chang, Lars Muhl, Bàrbara Laviña, Hanna Gladh, Guillem Genové, Christer Betsholtz, Erika Folestad, Karin Tran-Lundmark
Pulmonary hypertension (PH) is a lethal condition and current vasodilator therapy has limited effect. Anti-proliferative strategies targeting platelet-derived growth factor (PDGF) receptors, such as imatinib, have generated promising results in animal studies. Imatinib is however a non-specific tyrosine kinase inhibitor and has in clinical studies caused unacceptable adverse events. Further studies are needed on the role of PDGF signaling in PH. Here, mice expressing a variant of PDGF-B with no retention motif (Pdgfbret/ret), resulting in defective binding to extracellular matrix, were studied...
December 6, 2017: American Journal of Physiology. Lung Cellular and Molecular Physiology
https://www.readbyqxmd.com/read/29212555/study-partners-should-be-required-in-preclinical-alzheimer-s-disease-trials
#10
REVIEW
Joshua D Grill, Jason Karlawish
BACKGROUND: In an effort to intervene earlier in Alzheimer's disease (AD), clinical trials are testing promising candidate therapies in preclinical disease. Preclinical AD trial participants are cognitively normal, functionally independent, and autonomous decision-makers. Yet, like AD dementia trials, preclinical trials require dual enrollment of a participant and a knowledgeable informant, or study partner. MAIN TEXT: The requirement of dyadic enrollment is a barrier to recruitment and may present unique ethical challenges...
December 6, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/29212000/is-aggregate-dependent-yeast-aging-fortuitous-a-model-of-damage-segregation-and-aggregate-dynamics
#11
Martín Andrade-Restrepo
During cytokinesis in Saccharomyces cerevisiae, damaged proteins are distributed unequally between the daughter and mother cells. The retention of these proteins is correlated with yeast aging. Even though evidence suggests that aggregates are retained due to an underlying molecular mechanism, the debate on whether an active mechanism is necessary for this asymmetry remains unsolved. In particular, passive diffusion and a bud-specific dilution remain as possible explanations. Here, a computational and mathematical model is provided to test whether passive mechanisms alone are sufficient to account for the aggregate distribution patterns and the aggregate kinetics observed in living cells...
December 5, 2017: Biophysical Journal
https://www.readbyqxmd.com/read/29210686/a-modelling-study-of-the-event-based-retention-performance-of-green-roof-under-the-hot-humid-tropical-climate-in-kuching
#12
C T Chai, F J Putuhena, O S Selaman
The influences of climate on the retention capability of green roof have been widely discussed in existing literature. However, knowledge on how the retention capability of green roof is affected by the tropical climate is limited. This paper highlights the retention performance of the green roof situated in Kuching under hot-humid tropical climatic conditions. Using the green roof water balance modelling approach, this study simulated the hourly runoff generated from a virtual green roof from November 2012 to October 2013 based on past meteorological data...
December 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29208190/preventing-blood-borne-virus-infection-in-people-who-inject-drugs-in-the-uk-systematic-review-stakeholder-interviews-psychosocial-intervention-development-and-feasibility-randomised-controlled-trial
#13
Gail Gilchrist, Davina Swan, April Shaw, Ada Keding, Sarah Towers, Noel Craine, Alison Munro, Elizabeth Hughes, Steve Parrott, Noreen Mdege, John Strang, Avril Taylor, Judith Watson
BACKGROUND: Opioid substitution therapy and needle exchanges have reduced blood-borne viruses (BBVs) among people who inject drugs (PWID). Some PWID continue to share injecting equipment. OBJECTIVES: To develop an evidence-based psychosocial intervention to reduce BBV risk behaviours and increase transmission knowledge among PWID, and conduct a feasibility trial among PWID comparing the intervention with a control. DESIGN: A pragmatic, two-armed randomised controlled, open feasibility trial...
November 2017: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29203509/protocol-for-a-feasibility-study-and-randomised-pilot-trial-of-a-low-intensity-psychological-intervention-for-depression-in-adults-with-autism-the-autism-depression-trial-adept
#14
Ailsa Russell, Kate Cooper, Stephen Barton, Ian Ensum, Daisy Gaunt, Jeremy Horwood, Barry Ingham, David Kessler, Chris Metcalfe, Jeremy Parr, Dheeraj Rai, Nicola Wiles
INTRODUCTION: High rates of co-occurring depression are reported in autism spectrum disorder (ASD), a neurodevelopmental condition characterised by social communication impairments and repetitive behaviours. Cognitive-behavioural interventions adapted for ASD have been effective for anxiety problems. There have been evaluation studies of group cognitive-behavioural therapy for co-occurring depression, but no randomised trials investigating low-intensity psychological interventions as recommended in clinical guidelines for mild-moderate depression...
December 3, 2017: BMJ Open
https://www.readbyqxmd.com/read/29202786/perfected-enhanced-recovery-perfect-er-care-versus-standard-acute-care-for-patients-admitted-to-acute-settings-with-hip-fracture-identified-as-experiencing-confusion-study-protocol-for-a-feasibility-cluster-randomized-controlled-trial
#15
Simon P Hammond, Jane L Cross, Lee Shepstone, Tamara Backhouse, Catherine Henderson, Fiona Poland, Erika Sims, Alasdair MacLullich, Bridget Penhale, Robert Howard, Nigel Lambert, Anna Varley, Toby O Smith, Opinder Sahota, Simon Donell, Martyn Patel, Clive Ballard, John Young, Martin Knapp, Stephen Jackson, Justin Waring, Nick Leavey, Gregory Howard, Chris Fox
BACKGROUND: Health and social care provision for an ageing population is a global priority. Provision for those with dementia and hip fracture has specific and growing importance. Older people who break their hip are recognised as exceptionally vulnerable to experiencing confusion (including but not exclusively, dementia and/or delirium and/or cognitive impairment(s)) before, during or after acute admissions. Older people experiencing hip fracture and confusion risk serious complications, linked to delayed recovery and higher mortality post-operatively...
December 4, 2017: Trials
https://www.readbyqxmd.com/read/29197303/identification-and-structural-elucidation-of-a-new-sildenafil-analogue-dithiopropylcarbodenafil-from-a-premixed-powder-intended-as-a-dietary-supplement
#16
Jisuk Yun, Kye Jung Shin, Jangduck Choi, Kisung Kwon, Cheon-Ho Jo
A new sildenafil analogue was detected during the monitoring of a premixed powder intended as a dietary supplement. The ultraviolet (UV) spectrum of the unknown compound was similar to that of dithiodesmethylcarbodenafil and dithiodesethylcarbodenafil, although their corresponding HPLC peaks were observed at different retention times. The chemical structure of the unknown compound was characterized by liquid chromatography-quadrupole-time-of-flight mass spectrometry (LC-Q-TOF/MS), followed by nuclear magnetic resonance (NMR) and infrared (IR) spectroscopy...
November 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29187976/genome-comparisons-indicate-recent-transfer-of-wri-like-wolbachia-between-sister-species-drosophila-suzukii-and-d-%C3%A2-subpulchrella
#17
William R Conner, Mark L Blaxter, Gianfranco Anfora, Lino Ometto, Omar Rota-Stabelli, Michael Turelli
Wolbachia endosymbionts may be acquired by horizontal transfer, by introgression through hybridization between closely related species, or by cladogenic retention during speciation. All three modes of acquisition have been demonstrated, but their relative frequency is largely unknown. Drosophila suzukii and its sister species D. subpulchrella harbor Wolbachia, denoted wSuz and wSpc, very closely related to wRi, identified in California populations of D. simulans. However, these variants differ in their induced phenotypes: wRi causes significant cytoplasmic incompatibility (CI) in D...
November 2017: Ecology and Evolution
https://www.readbyqxmd.com/read/29184901/evaluating-and-improving-recruitment-and-retention-in-an-mhealth-clinical-trial-an-example-of-iterating-methods-during-a-trial
#18
Angela Fidler Pfammatter, Alexa Mitsos, Shirlene Wang, Susan Hammett Hood, Bonnie Spring
Background: Recruitment and retention strategy investigations in mHealth clinical trials are rare. Technology presents an opportunity to intensely and remotely evaluate recruitment, use of mobile apps, and retention, leading to new insights for continuous improvement of mHealth trials. The objective of this paper is to present a case study in which a trial evaluated and changed strategies during a clinical trial to improve recruitment, adherence to study protocols, and retention in the mHealth trial...
2017: MHealth
https://www.readbyqxmd.com/read/29183359/acute-on-chronic-bilateral-subdural-hematoma-presenting-with-acute-complete-flaccid-paraplegia-and-urinary-retention-mimicking-an-acute-spinal-cord-injury-a-case-report
#19
H M M T B Herath, Anne Thushara Matthias, Aruna Kulatunga
BACKGROUND: A subdural hematoma refers to a collection of blood between the dura and the arachnoid membranes and is classified into acute, sub acute and chronic. Subdural hematoma has been referred to as the "great neurologic imitator" as it can mimic many neurological conditions. CASE PRESENTATION: Forty-three year old Sri Lankan female presented 2 weeks following traumatic head injury with bilateral flaccid complete paraplegia and urinary retention. Her non-contrast computer tomography of the brain revealed bilateral acute, chronic subdural hematomas...
November 28, 2017: BMC Research Notes
https://www.readbyqxmd.com/read/29182451/protein-recommendations-for-weight-loss-in-elite-athletes-a-focus-on-body-composition-and-performance
#20
Amy Hector, Stuart M Phillips
There exists a large body of scientific evidence to support protein intakes in excess of the recommended dietary allowance (RDA) (0.8g protein/kg/d) to promote the retention of skeletal muscle and loss of adipose tissue during dietary energy restriction. Diet-induced weight loss with as low as possible ratio of skeletal muscle to fat mass loss is a situation we refer to as high quality weight loss. We propose that high quality weight loss is often of importance to elite athletes in order to maintain their muscle (engine) and shed unwanted fat mass, potentially improving athletic performance...
November 28, 2017: International Journal of Sport Nutrition and Exercise Metabolism
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