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https://www.readbyqxmd.com/read/29458055/brain-activation-associated-to-olfactory-conditioned-same-sex-partner-preference-in-male-rats
#1
Genaro A Coria-Avila, Tamara Cibrian-Llanderal, Victor X Díaz-Estrada, Luis I García, Rebeca Toledo-Cárdenas, James G Pfaus, Jorge Manzo
Sexual preferences can be strongly modified by Pavlovian learning. For instance, olfactory conditioned same-sex partner preference can occur when a sexually naïve male cohabits with an scented male during repeated periods under the effects of enhanced D2-type activity. Preference is observed days later via social and sexual behaviors. Herein we explored brain activity related to learned same-sex preference (Fos-Immunoreactivity, IR) following exposure to a conditioned odor paired with same-sex preference. During conditioning trials males received either saline or the D2-type receptor agonist quinpirole (QNP) and cohabitated during 24 h with a stimulus male that bore almond scent on the back as conditioned stimulus...
February 16, 2018: Hormones and Behavior
https://www.readbyqxmd.com/read/29457647/learning-of-hierarchical-serial-patterns-emerges-in-infancy
#2
David J Lewkowicz, Mark A Schmuckler, Diane M J Mangalindan
Recursive, hierarchically organized serial patterns provide the underlying structure in many cognitive and motor domains including speech, language, music, social interaction, and motor action. We investigated whether learning of hierarchical patterns emerges in infancy by habituating 204 infants to different hierarchical serial patterns and then testing for discrimination and generalization of such patterns. Results indicated that 8- to 10-month-old and 12- to 14-month-old infants exhibited sensitivity to the difference between hierarchical and non-hierarchical structure but that 4- to 6-month-old infants did not...
February 19, 2018: Developmental Psychobiology
https://www.readbyqxmd.com/read/29457601/influences-of-combined-traffic-noise-on-the-ability-of-learning-and-memory-in-mice
#3
Guo-Qing Di, Zhao-Qi Qin
Objective: The present study aimed to evaluate the influences of combined traffic noise (CTN) on the ability of learning and memory in mice. Materials and Methods: The Institute of Cancer Research (ICR) mice were exposed to CTN from highways and high-speed railways for 42 days, whose day-night equivalent continuous A-weighted sound pressure level (Ldn ) was 70 dB(A). On the basis of behavioral reactions in Morris water maze (MWM) and the concentrations of amino acid neurotransmitters in the hippocampus, the impacts of CTN on learning and memory in mice were examined...
January 2018: Noise & Health
https://www.readbyqxmd.com/read/29457585/training-nurses-in-a-competency-framework-to-support-adults-with-epilepsy-and-intellectual-disability-the-epaid-cluster-rct
#4
Howard Ring, James Howlett, Mark Pennington, Christopher Smith, Marcus Redley, Caroline Murphy, Roxanne Hook, Adam Platt, Nakita Gilbert, Elizabeth Jones, Joanna Kelly, Angela Pullen, Adrian Mander, Cam Donaldson, Simon Rowe, James Wason, Fiona Irvine
BACKGROUND: People with an intellectual (learning) disability (ID) and epilepsy have an increased seizure frequency, higher frequencies of multiple antiepileptic drug (AED) use and side effects, higher treatment costs, higher mortality rates and more behavioural problems than the rest of the population with epilepsy. The introduction of nurse-led care may lead to improvements in outcome for those with an ID and epilepsy; however, this has not been tested in a definitive clinical trial...
February 2018: Health Technology Assessment: HTA
https://www.readbyqxmd.com/read/29456645/influence-of-exposure-to-nicotine-during-pregnancy-on-the-learning-and-memory-for-adult-offspring
#5
Xing-Dui Ma, Bei-Ping Li, Yuan Han, Yun-Ping Tian, Liang Wu, Hang Wang
We aimed to investigate the indirect influence of exposure to nicotine during pregnancy on the learning and memory of adult offspring mice. Thirty pregnant C57 mice were randomly divided into either the control group (CON) or the nicotine group (NIC), with 15 mice each. The CON group was given access to drug-free water, and the NIC group was given 60 g/ml nicotine in drinking water. Sixteen adult mice were randomly selected from the 8 litters for Morris water maze test. The level of products of related factors in the hippocampus of mice in the NIC and the CON groups were compared using the1 H-MRS method...
March 2018: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29455926/unravelling-salutogenic-mechanisms-in-the-workplace-the-role-of-learning
#6
Roald Pijpker, Lenneke Vaandrager, Evert Jan Bakker, Maria Koelen
OBJECTIVE: To explore the moderating and mediating role(s) of learning within the relationship between sense of coherence (SOC) and generalized resistance resources. METHOD: Cross-sectional study (N=481), using a self-administered questionnaire, of employees working in the healthcare sector in the Netherlands in 2017. Four residential healthcare settings and one healthcare-related Facebook group were involved. Multiple linear regression models were used to test for moderating and mediating effects of learning...
February 15, 2018: Gaceta Sanitaria
https://www.readbyqxmd.com/read/29455676/evaluation-of-an-ophthalmoscopy-simulator-to-teach-funduscopy-skills-to-pediatric-residents
#7
Elizabeth Kouzmitcheva, Stephanie A Grover, Tara Berenbaum, Asim Ali, Adelle Atkinson, E Ann Yeh
BACKGROUND: Medical school and residency training in ophthalmoscopic evaluation is limited, reducing diagnostic accuracy. We sought to evaluate the efficacy of self-study using an ophthalmoscopy simulator to improve the technical motor skills involved in direct funduscopy in postgraduate pediatric residents. METHODS: In this randomized-controlled study, 17 pediatric residents (postgraduate years 1-3) were randomized to control (n=8) or intervention (n=9) groups...
February 19, 2018: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/29454491/risk-assessment-for-ballast-water-management-learning-from-the-adriatic-sea-case-study
#8
Matej David, Stephan Gollasch
The ballast water management convention incorporates principles of risk assessment. A new ballast water management risk assessment model was developed to support the implementation of most efficient management measures, which we also present as a flowchart decision support system model. The risk assessment model was tested using data from port baseline surveys where available, and real shipping and ballast water discharges data. The here presented ballast water management risk assessment and possible management options are applicable elsewhere to support and improve complex decision making in the implementation of management requirements according to the ballast water management convention...
February 14, 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29454085/effects-of-orientation-and-differential-reinforcement-ii-transitivity-and-transfer-across-five-member-sets
#9
Micah Amd, Marlon A de Oliveira, Denise A Passarelli, Livia C Balog, Julio C de Rose
A recent report by Amd and colleagues (2017) demonstrated that orienting towards successively presented stimulus-stimulus pairs yielded significantly more transitive relations then when those same pairs were differentially reinforced following training for three, 3-member stimulus sets. We build on that work in four important ways. First, transitivity yields produced by Pavlovian and instrumental procedures were compared following training for three 5-member sets (A1-B1-C1-D1-E1, A2-B2-C2-D2-E2, A3-B3-C3-D3-E3), where the 'A' stimuli were emotional faces and all remaining stimuli were nonsense words...
February 14, 2018: Behavioural Processes
https://www.readbyqxmd.com/read/29454038/dendritic-cells-as-cancer-therapeutics
#10
REVIEW
Christian E Bryant, Sarah Sutherland, Benjamin Kong, Michael S Papadimitrious, Derek N J Hart
The ability of immune therapies to control cancer has recently generated intense interest. This therapeutic outcome is reliant on T cell recognition of tumour cells. The natural function of dendritic cells (DC) is to generate adaptive responses, by presenting antigen to T cells, hence they are a logical target to generate specific anti-tumour immunity. Our understanding of the biology of DC is expanding, and they are now known to be a family of related subsets with variable features and function. Most clinical experience to date with DC vaccination has been using monocyte-derived DC vaccines...
February 14, 2018: Seminars in Cell & Developmental Biology
https://www.readbyqxmd.com/read/29453206/elevation-of-hippocampal-neurogenesis-induces-a-temporally-graded-pattern-of-forgetting-of-contextual-fear-memories
#11
Aijing Gao, Frances Xia, Axel Guskjolen, Adam I Ramsaran, Adam Santoro, Sheena A Josselyn, Paul W Frankland
Throughout life neurons are continuously generated in the subgranular zone of the hippocampus. The subsequent integration of newly-generated neurons alters patterns of dentate gyrus input and output connectivity, potentially rendering memories already stored in those circuits harder to access. Consistent with this prediction, we previously showed that increasing hippocampal neurogenesis after training induces forgetting of hippocampus-dependent memories, including contextual fear memory. However, the brain regions supporting contextual fear memories change with time, and this time-dependent memory reorganization might regulate the sensitivity of contextual fear memories to fluctuations in hippocampal neurogenesis...
February 16, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/29452923/statistical-and-machine-learning-approaches-to-predicting-protein-ligand-interactions
#12
REVIEW
Lucy J Colwell
Data driven computational approaches to predicting protein-ligand binding are currently achieving unprecedented levels of accuracy on held-out test datasets. Up until now, however, this has not led to corresponding breakthroughs in our ability to design novel ligands for protein targets of interest. This review summarizes the current state of the art in this field, emphasizing the recent development of deep neural networks for predicting protein-ligand binding. We explain the major technical challenges that have caused difficulty with predicting novel ligands, including the problems of sampling noise and the challenge of using benchmark datasets that are sufficiently unbiased that they allow the model to extrapolate to new regimes...
February 13, 2018: Current Opinion in Structural Biology
https://www.readbyqxmd.com/read/29452811/effects-on-adult-cognitive-function-after-neonatal-exposure-to-clinically-relevant-doses-of-ionising-radiation-and-ketamine-in-mice
#13
S Buratovic, B Stenerlöw, S Sundell-Bergman, A Fredriksson, H Viberg, T Gordh, P Eriksson
BACKGROUND: Radiological methods for screening, diagnostics and therapy are frequently used in healthcare. In infants and children, anaesthesia/sedation is often used in these situations to relieve the patients' perception of stress or pain. Both ionising radiation (IR) and ketamine have been shown to induce developmental neurotoxic effects and this study aimed to identify the combined effects of these in a murine model. METHODS: Male mice were exposed to a single dose of ketamine (7...
March 2018: British Journal of Anaesthesia
https://www.readbyqxmd.com/read/29452755/machine-learning-algorithms-based-on-signals-from-a-single-wearable-inertial-sensor-can-detect-surface-and-age-related-differences-in-walking
#14
B Hu, P C Dixon, J V Jacobs, J T Dennerlein, J M Schiffman
The aim of this study was to investigate if a machine learning algorithm utilizing triaxial accelerometer, gyroscope, and magnetometer data from an inertial motion unit (IMU) could detect surface- and age-related differences in walking. Seventeen older (71.5 ± 4.2 years) and eighteen young (27.0 ± 4.7 years) healthy adults walked over flat and uneven brick surfaces wearing an inertial measurement unit (IMU) over the L5 vertebra. IMU data were binned into smaller data segments using 4-s sliding windows with 1-s step lengths...
January 12, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29452047/lessons-learned-from-ebola-vaccine-r-d-during-a-public-health-emergency
#15
Marie-Paule Kieny
In spite of a complete lack of Research and Development (R&D) preparedness, the 2013-2016 West-Africa Ebola experience demonstrated that it is possible to compress R&D timelines to less than a single year, from a more usual decade or longer. This is mostly to be credited to an unprecedented collaborative effort building on the availability of a small number of candidate diagnostic tests, drugs and vaccines that could be moved rapidly into the clinical phase evaluation. The World Health Organization (WHO) led international consultations and activities - including the organization of a successful Ebola vaccine efficacy trial in Guinea - as a contribution to the unprecedented global efforts to control the Ebola epidemic...
February 16, 2018: Human Vaccines & Immunotherapeutics
https://www.readbyqxmd.com/read/29451446/improving-patient-safety-during-introduction-of-novel-medical-devices-through-cumulative-summation-analysis
#16
Vejay N Vakharia, Roman Rodionov, Andrew W McEvoy, Anna Miserocchi, Rachel Sparks, Aidan G O'Keeffe, Sebastien Ourselin, John S Duncan
OBJECTIVE The aim of this study was to implement cumulative summation (CUSUM) analysis as an early-warning detection and quality assurance system for preclinical testing of the iSYS1 novel robotic trajectory guidance system. METHODS Anatomically accurate 3D-printed skull phantoms were created for 3 patients who underwent implantation of 21 stereoelectroencephalography electrodes by surgeons using the current standard of care (frameless technique). Implantation schema were recreated using the iSYS1 system, and paired accuracy measures were compared with the previous frameless implantations...
February 16, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29451082/the-short-term-placebo-response-in-children-with-attention-deficit-hyperactivity-disorder-adhd
#17
Ayala Cohen, Moran Plonsky-Toder, Emanuel Tirosh
To assess short-term placebo response in 6- to 13-year-old children with ADHD, children who were administered a double-blind placebo-methylphenidate trial, 1 week each, were included in the analysis. Conners' parents and Teacher Rating scales, the Aggregate Neurobehavioral Student Health and Educational Review inventory, and the Matching Familiar Figure Test were employed. A reduction of 30% or more in one or more of the teachers report subscales was observed in 18.8% of the participants. Attention test performance resulted in 58% of children exhibiting reduction in error rates and 36...
January 1, 2018: Journal of Child Neurology
https://www.readbyqxmd.com/read/29450789/control-by-association-transfer-of-implicitly-primed-attentional-states-across-linked-stimuli
#18
Christina Bejjani, Ziwei Zhang, Tobias Egner
Although cognitive control has traditionally been viewed in opposition to associative learning, recent studies show that people can learn to link particular stimuli with specific cognitive control states (e.g., high attentional selectivity). Here, we tested whether such learned stimulus-control associations can transfer across paired-associates. In the Stimulus-Stimulus (S-S) Association phase, specific face or house images repeatedly preceded the presentation of particular scene stimuli, creating paired face/house-scene associates in memory...
February 15, 2018: Psychonomic Bulletin & Review
https://www.readbyqxmd.com/read/29450642/risk-factors-of-non-specific-spinal-pain-in-childhood
#19
Julia Szita, Sara Boja, Agnes Szilagyi, Annamaria Somhegyi, Peter Pal Varga, Aron Lazary
PURPOSE: Non-specific spinal pain can occur at all ages and current evidence suggests that pediatric non-specific spinal pain is predictive for adult spinal conditions. A 5-year long, prospective cohort study was conducted to identify the lifestyle and environmental factors leading to non-specific spinal pain in childhood. MATERIALS AND METHODS: Data were collected from school children aged 7-16 years, who were randomly selected from three different geographic regions in Hungary...
February 15, 2018: European Spine Journal
https://www.readbyqxmd.com/read/29449819/knowledge-is-power-for-medical-assistants-crystallized-and-fluid-intelligence-as-predictors-of-vocational-knowledge
#20
Anne Moehring, Ulrich Schroeders, Oliver Wilhelm
Medical education research has focused almost entirely on the education of future physicians. In comparison, findings on other health-related occupations, such as medical assistants, are scarce. With the current study, we wanted to examine the knowledge-is-power hypothesis in a real life educational setting and add to the sparse literature on medical assistants. Acquisition of vocational knowledge in vocational education and training (VET) was examined for medical assistant students ( n = 448). Differences in domain-specific vocational knowledge were predicted by crystallized and fluid intelligence in the course of VET...
2018: Frontiers in Psychology
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