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Minimal cognitive impairment (MCI)

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https://www.readbyqxmd.com/read/29165763/neuropsychological-intervention-of-minimal-cognitive-impairment-including-language-deficits
#1
Y Zhao, H Li
OBJECTIVE: Mild Cognitive Impairment (MCI) is an early dementia or discrete memory loss. The cognitive deficit in MCI impedes people's daily activities, which influences multiple aspects of thinking and acting including attention, reading, writing, reasoning, language, and judgment. This review aims to assess the outcome of various neuropsychological interventions in treating MCI. MATERIALS AND METHODS: MCI causes memory problems and is characterized by the cognitive damage that is disproportionate about individual education background and age...
October 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/29071500/temporal-association-patterns-and-dynamics-of-amyloid-%C3%AE-and-tau-in-alzheimer-s-disease
#2
Alison K Ower, Christoforos Hadjichrysanthou, Luuk Gras, Jaap Goudsmit, Roy M Anderson, Frank de Wolf
The elusive relationship between underlying pathology and clinical disease hampers diagnosis of Alzheimer's disease (AD) and preventative intervention development. We seek to understand the relationship between two classical AD biomarkers, amyloid-β1-42 (Aβ1-42) and total-tau (t-tau), and define their trajectories across disease development, as defined by disease onset at diagnosis of mild cognitive impairment (MCI). Using longitudinal data from the Alzheimer's Disease Neuroimaging Initiative (ADNI), we performed a correlation analysis of biomarkers CSF Aβ1-42 and t-tau, and longitudinal quantile analysis...
October 25, 2017: European Journal of Epidemiology
https://www.readbyqxmd.com/read/28912299/the-test-your-memory-for-mild-cognitive-impairment-tym-mci
#3
Jeremy M Brown, Claire J Lansdall, Julie Wiggins, Kate E Dawson, Kristina Hunter, James B Rowe, Richard A Parker
BACKGROUND: To validate a short cognitive test: the Test Your Memory for Mild Cognitive Impairment (TYM-MCI) in the diagnosis of patients with amnestic mild cognitive impairment or mild Alzheimer's disease (aMCI/AD). METHODS: Two hundred and two patients with mild memory problems were recruited. All had 'passed' the Mini-Mental State Examination (MMSE). Patients completed the TYM-MCI, the Test Your Memory test (TYM), MMSE and revised Addenbrooke's Cognitive Examination (ACE-R), had a neurological examination, clinical diagnostics and multidisciplinary team review...
September 14, 2017: Journal of Neurology, Neurosurgery, and Psychiatry
https://www.readbyqxmd.com/read/28855146/categorizing-health-outcomes-and-efficacy-of-mhealth-apps-for-persons-with-cognitive-impairment-a-systematic-review
#4
REVIEW
Daniel R Bateman, Bhavana Srinivas, Thomas W Emmett, Titus K Schleyer, Richard J Holden, Hugh C Hendrie, Christopher M Callahan
BACKGROUND: Use of mobile health (mHealth) apps is growing at an exponential rate in the United States and around the world. Mild cognitive impairment (MCI), Alzheimer disease, and related dementias are a global health problem. Numerous mHealth interventions exist for this population, yet the effect of these interventions on health has not been systematically described. OBJECTIVE: The aim of this study is to catalog the types of health outcomes used to measure effectiveness of mHealth interventions and assess which mHealth interventions have been shown to improve the health of persons with MCI, Alzheimer disease, and dementia...
August 30, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28771679/longitudinal-cognitive-profiles-in-diabetes-results-from-the-national-alzheimer-s-coordinating-center-s-uniform-data
#5
Mary Sano, Carolyn W Zhu, Hillel Grossman, Corbett Schimming
BACKGROUND: Diabetes is a risk factor for the development of cognitive impairment and possibly for accelerated progression to Alzheimer disease (AD) and other dementias, though the trajectory of cognitive decline in general and in specfic cognitive domains by diabetes is unclear. METHODS: Using the National Alzheimer's Coordinating Center's Uniform Data Det (NACC-UDS) to identify cohorts of elders with normal cognition (N = 7,663) and mild cognitive impairment (MCI, N = 4,114), we compared overall cognitive composite and domain specific sub-scores and their progression over time between diabetic and non-diabetic subjects...
October 2017: Journal of the American Geriatrics Society
https://www.readbyqxmd.com/read/28754233/development-and-validation-of-an-alternative-version-of-the-parkinson-s-disease-cognitive-rating-scale-pd-crs
#6
Ramón Fernández-Bobadilla, Saül Martínez-Horta, Juan Marín-Lahoz, Andrea Horta-Barba, Javier Pagonabarraga, Jaime Kulisevsky
INTRODUCTION: The Parkinson's Disease-Cognitive Rating Scale (PD-CRS) is a valid and reliable instrument to screen for and diagnose mild cognitive impairment in PD (PD-MCI) and to monitor potential outcomes in clinical trials. Although this scale shows adequate sensitivity to change in non-demented PD patients, an alternative form (AF) with proven reliability could minimize practice effects associated with repeated testing. METHODS: We selected PD-CRS/AF items following the criteria proposed in the original PD-CRS...
July 19, 2017: Parkinsonism & related Disorders
https://www.readbyqxmd.com/read/28670650/structured-outlier-detection-in-neuroimaging-studies-with-minimal-convex-polytopes
#7
Erdem Varol, Aristeidis Sotiras, Christos Davatzikos
Computer assisted imaging aims to characterize disease processes by contrasting healthy and pathological populations. The sensitivity of these analyses is hindered by the variability in the neuroanatomy of the normal population. To alleviate this shortcoming, it is necessary to define a normative range of controls. Moreover, elucidating the structure in outliers may be important in understanding diverging individuals and characterizing prodromal disease states. To address these issues, we propose a novel geometric concept called minimal convex polytope (MCP)...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28587629/efficacy-of-the-ubiquitous-spaced-retrieval-based-memory-advancement-and-rehabilitation-training-usmart-program-among-patients-with-mild-cognitive-impairment-a-randomized-controlled-crossover-trial
#8
Ji Won Han, Kyung Lak Son, Hye Jin Byun, Ji Won Ko, Kayoung Kim, Jong Woo Hong, Tae Hyun Kim, Ki Woong Kim
BACKGROUND: Spaced retrieval training (SRT) is a nonpharmacological intervention for mild cognitive impairment (MCI) and dementia that trains the learning and retention of target information by recalling it over increasingly long intervals. We recently developed the Ubiquitous Spaced Retrieval-based Memory Advancement and Rehabilitation Training (USMART) program as a convenient, self-administered tablet-based SRT program. We also demonstrated the utility of USMART for improving memory in individuals with MCI through an open-label uncontrolled trial...
June 6, 2017: Alzheimer's Research & Therapy
https://www.readbyqxmd.com/read/28534428/clinimetric-validity-of-the-trail-making-test-czech-version-in-parkinson-s-disease-and-normative-data-for-older-adults
#9
Ondrej Bezdicek, Hana Stepankova, Bradley N Axelrod, Tomas Nikolai, Zdenek Sulc, Robert Jech, Evžen Růžička, Miloslav Kopecek
OBJECTIVE: The influence of demographic variables on the Trail Making Test (TMT) performance in older individuals and empirical findings on clinical validity in predementia states, such as Parkinson's disease mild cognitive impairment (PD-MCI), are limited. The principal aim of this study was to add normative data for the Czech population of older adults and explore the clinimetric properties between PD-MCI and PD patients with normal cognition (PD-NC). METHOD: The study included 125 PD patients classified as 77 PD-MCI and 48 PD-NC and 528 older individuals (60-74 years, further subdivided for normative tables into 60-64, 65-69 and 70-74 age groups) and very old individuals (aged 75-96, further subdivided into 75-79, 80-84, 85-96) cognitively intact Czech adults...
May 23, 2017: Clinical Neuropsychologist
https://www.readbyqxmd.com/read/28438167/dependency-criterion-based-brain-pathological-age-estimation-of-alzheimer-s-disease-patients-with-mr-scans
#10
Yongming Li, Yuchuan Liu, Pin Wang, Jie Wang, Sha Xu, Mingguo Qiu
OBJECTIVES: Traditional brain age estimation methods are based on the idea that uses the real age as the training label. However, these methods ignore that there is a deviation between the real age and the brain age due to the accelerated brain aging. METHODS: This paper considers this deviation and obtains it by maximizing the correlation between the estimated brain age and the class label rather than by minimizing the difference between the estimated brain age and the real age...
April 24, 2017: Biomedical Engineering Online
https://www.readbyqxmd.com/read/28397182/evaluation-and-clinical-correlation-of-practical-cut-offs-for-visual-rating-scales-of-atrophy-normal-aging-versus-mild-cognitive-impairment-and-alzheimer-s-disease
#11
Anne-Sophie Vanhoenacker, Bernard Sneyers, Frederik De Keyzer, Sam Heye, Philippe Demaerel
Age-related brain atrophy is a common finding, but neurodegenerative diseases such as Alzheimer's disease are associated with accelerated atrophy of the medial temporal lobe. In current practice for brain atrophy evaluation, several rating scales are being used such as the medial temporal atrophy (MTA), global cortical atrophy-frontal subscale (GCA-F) and posterior atrophy (PA) scales. Practical cut-offs to differentiate between normal and advanced brain atrophy are needed, because of their possible usefulness as a biomarker...
September 2017: Acta Neurologica Belgica
https://www.readbyqxmd.com/read/28346565/anticholinergic-burden-and-functional-status-in-older-people-with-cognitive-impairment-results-from-the-regal-project
#12
V Boccardi, M Baroni, L Paolacci, S Ercolani, A Longo, M Giordano, C Ruggiero, P Mecocci
OBJECTIVE: The use of drugs with intrinsic anticholinergic properties is widespread among old age persons. A growing body of evidences suggest that a high anticholinergic burden is associated with physical and cognitive impairment. However, the association between anticholinergic drug use and functional status is still poorly investigated, particularly among subjects with initial cognitive impairment. DESIGN: Cross-sectional study examining the association between drug-related anticholinergic burden and functional status in cognitively healthy (CH) (n=691), mild cognitive impairment (MCI) (n=541) or mild Alzheimer's diseases (AD) (n=1127) subjects...
2017: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/28304301/modeling-the-relationships-among-late-life-body-mass-index-cerebrovascular-disease-and-alzheimer-s-disease-neuropathology-in-an-autopsy-sample-of-1-421-subjects-from-the-national-alzheimer-s-coordinating-center-data-set
#13
Michael L Alosco, Jonathan Duskin, Lilah M Besser, Brett Martin, Christine E Chaisson, John Gunstad, Neil W Kowall, Ann C McKee, Robert A Stern, Yorghos Tripodis
The relationship between late-life body mass index (BMI) and Alzheimer's disease (AD) is poorly understood due to the lack of research in samples with autopsy-confirmed AD neuropathology (ADNP). The role of cerebrovascular disease (CVD) in the interplay between late-life BMI and ADNP is unclear. We conducted a retrospective longitudinal investigation and used joint modeling of linear mixed effects to investigate causal relationships among repeated antemortem BMI measurements, CVD (quantified neuropathologically), and ADNP in an autopsy sample of subjects across the AD clinical continuum...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28179587/profile-of-6-microrna-in-blood-plasma-distinguish-early-stage-alzheimer-s-disease-patients-from-non-demented-subjects
#14
Siranjeevi Nagaraj, Katarzyna Laskowska-Kaszub, Konrad J Dębski, Joanna Wojsiat, Michał Dąbrowski, Tomasz Gabryelewicz, Jacek Kuźnicki, Urszula Wojda
Alzheimer's disease (AD) is the most common age-related dementia. Among its major challenges is identifying molecular signatures characteristic for the early AD stage in patients with Mild Cognitive Impairment (MCI-AD), which could serve for deciphering the AD pathomechanism and also as non-invasive, easy-to-access biomarkers. Using qRT-PCR we compared the microRNA (miRNA) profiles in blood plasma of 15 MCI-AD patients, whose diagnoses were confirmed by cerebrospinal fluid (CSF) biomarkers, with 20 AD patients and 15 non-demented, age-matched individuals (CTR)...
March 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/27670209/validation-of-montreal-cognitive-assessment-moca-alternate-french-versions
#15
Ziad Samir Nasreddine, Bhavini Bhovan Patel
UNLABELLED: Objective background: The Montreal Cognitive Assessment (MoCA) is a questionnaire that has been developed to help physicians around the world diagnose a patient's cognitive ability. Available in multiple languages and for use in multiple countries worldwide, the goal of this study was to validate the alternate versions 2 and 3 of the French MoCA test to assist physicians in the detection of mild cognitive impairment (MCI), while decreasing the learning effect upon frequent testing...
September 2016: Canadian Journal of Neurological Sciences. le Journal Canadien des Sciences Neurologiques
https://www.readbyqxmd.com/read/27649031/estimating-the-brain-pathological-age-of-alzheimer-s-disease-patients-from-mr-image-data-based-on-the-separability-distance-criterion
#16
Yongming Li, Fan Li, Pin Wang, Xueru Zhu, Shujun Liu, Mingguo Qiu, Jingna Zhang, Xiaoping Zeng
Traditional age estimation methods are based on the same idea that uses the real age as the training label. However, these methods ignore that there is a deviation between the real age and the brain age due to accelerated brain aging. This paper considers this deviation and searches for it by maximizing the separability distance value rather than by minimizing the difference between the estimated brain age and the real age. Firstly, set the search range of the deviation as the deviation candidates according to prior knowledge...
October 7, 2016: Physics in Medicine and Biology
https://www.readbyqxmd.com/read/27499305/characterizing-magnitude-and-selectivity-of-attrition-in-a-study-of-mild-cognitive-impairment
#17
D Facal, O Juncos-Rabadán, J Guardia-Olmos, A X Pereiro, C Lojo-Seoane
OBJECTIVES: Attrition is one of the greatest difficulties in longitudinal studies on cognitive ageing because of the associated risk of underestimating declines. The aims of this paper were to characterize the magnitude and selectivity of attrition in a study of mild cognitive impairment. DESIGN: Forty two patients with multiple-domain amnestic MCI, 71 with single-domain amnestic MCI, 35 with non-amnestic MCI and 318 healthy controls were recruited from primary care centers and assessed at baseline...
2016: Journal of Nutrition, Health & Aging
https://www.readbyqxmd.com/read/27489003/extracting-patterns-of-morphometry-distinguishing-hiv-associated-neurodegeneration-from-mild-cognitive-impairment-via-group-cardinality-constrained-classification
#18
Yong Zhang, Dongjin Kwon, Pardis Esmaeili-Firidouni, Adolf Pfefferbaum, Edith V Sullivan, Harold Javitz, Victor Valcour, Kilian M Pohl
HIV-Associated Neurocognitive Disorder (HAND) is the most common constellation of cognitive dysfunctions in chronic HIV infected patients age 60 or older in the U.S. Only few published methods assist in distinguishing HAND from other forms of age-associated cognitive decline, such as Mild Cognitive Impairment (MCI). In this report, a data-driven, nonparameteric model to identify morphometric patterns separating HAND from MCI due to non-HIV conditions in this older age group was proposed. This model enhanced the potential for group separation by combining a smaller, longitudinal data set containing HAND samples with a larger, public data set including MCI cases...
December 2016: Human Brain Mapping
https://www.readbyqxmd.com/read/27408938/plasma-phospholipids-and-prevalence-of-mild-cognitive-impairment-and-or-dementia-in-the-aric-neurocognitive-study-aric-ncs
#19
Danni Li, Jeffrey R Misialek, Eric Boerwinkle, Rebecca F Gottesman, A Richey Sharrett, Thomas H Mosley, Josef Coresh, Lisa M Wruck, David S Knopman, Alvaro Alonso
INTRODUCTION: Phospholipids are altered in brains of patients with dementia and some studies suggest their plasma levels may be useful in the detection of mild cognitive impairment (MCI) and dementia. METHODS: We measured 188 plasma metabolites in participants who underwent a detailed neuropsychological assessment and classified as normal (n = 153), MCI (n = 145), or dementia (n = 143) by expert adjudication. RESULTS: Among 10 phospholipids recently implicated as altered in dementia, higher concentration of PC aa C36:6 was significantly associated with decreased prevalence of dementia (odds ratio = 0...
2016: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring
https://www.readbyqxmd.com/read/27144494/robustness-of-reliable-change-indices-to-variability-in-parkinson-s-disease-with-mild-cognitive-impairment
#20
RANDOMIZED CONTROLLED TRIAL
T H Turner, J B Renfroe, J Elm, A Duppstadt-Delambo, V K Hinson
Ability to identify change is crucial for measuring response to interventions and tracking disease progression. Beyond psychometrics, investigations of Parkinson's disease with mild cognitive impairment (PD-MCI) must consider fluctuating medication, motor, and mental status. One solution is to employ 90% reliable change indices (RCIs) from test manuals to account for account measurement error and practice effects. The current study examined robustness of 90% RCIs for 19 commonly used executive function tests in 14 PD-MCI subjects assigned to the placebo arm of a 10-week randomized controlled trial of atomoxetine in PD-MCI...
November 2016: Applied Neuropsychology. Adult
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