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Prodromal AD

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https://www.readbyqxmd.com/read/28522082/brain-perfusion-during-rapid-eye-movement-sleep-successfully-identifies-amnestic-mild-cognitive-impairment
#1
Pauline Brayet, Dominique Petit, Andrée-Ann Baril, Nadia Gosselin, Jean-François Gagnon, Jean-Paul Soucy, Serge Gauthier, Marie-Jeanne Kergoat, Julie Carrier, Isabelle Rouleau, Jacques Montplaisir
INTRODUCTION: Prodromal markers of Alzheimer's disease (AD) have been derived from wakefulness. However, brain perfusion during rapid-eye movement (REM) sleep could be a sensitive marker of amnestic mild cognitive impairment (aMCI), as activation of REM sleep relies more on the cholinergic system. METHODS: Eight subjects with aMCI, and 16 controls, underwent two single-photon emission computed tomography (SPECT) scans with tracer injected during REM sleep then wakefulness...
June 2017: Sleep Medicine
https://www.readbyqxmd.com/read/28507319/longitudinal-changes-of-tau-pet-imaging-in-relation-to-hypometabolism-in-prodromal-and-alzheimer-s-disease-dementia
#2
K Chiotis, L Saint-Aubert, E Rodriguez-Vieitez, A Leuzy, O Almkvist, I Savitcheva, M Jonasson, M Lubberink, A Wall, G Antoni, A Nordberg
The development of tau-specific positron emission tomography (PET) tracers allows imaging in vivo the regional load of tau pathology in Alzheimer's disease (AD) and other tauopathies. Eighteen patients with baseline investigations enroled in a 17-month follow-up study, including 16 with AD (10 had mild cognitive impairment and a positive amyloid PET scan, that is, prodromal AD, and six had AD dementia) and two with corticobasal syndrome. All patients underwent PET scans with [(18)F]THK5317 (tau deposition) and [(18)F]FDG (glucose metabolism) at baseline and follow-up, neuropsychological assessment at baseline and follow-up and a scan with [(11)C]PIB (amyloid-β deposition) at baseline only...
May 16, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28499898/antidepressant-drugs-for-beta-amyloid-induced-depression-a-new-standpoint
#3
Schiavone Stefania, Tucci Paolo, Mhillaj Emanuela, Bove Maria, Trabace Luigia, Morgese Maria Grazia
Mounting evidence suggests that depression represents a risk factor and an early manifestation of Alzheimer's disease (AD). Neuropsychiatric symptoms may derive from neurobiological changes in specific brain areas and may be considered prodromal of dementia. We have previously reported the depressive-like profile in rats receiving a single intracerebroventricular injection of soluble amyloid beta protein (ßA). Here, we verified the effect of different classes of antidepressants on the ßA-induced depressive behavior and on cortical monoamine levels...
May 9, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/28484387/functional-connectivity-disruption-in-subjective-cognitive-decline-and-mild-cognitive-impairment-a-common-pattern-of-alterations
#4
David López-Sanz, Ricardo Bruña, Pilar Garcés, María Carmen Martín-Buro, Stefan Walter, María Luisa Delgado, Mercedes Montenegro, Ramón López Higes, Alberto Marcos, Fernando Maestú
Functional connectivity (FC) alterations represent a key feature in Alzheimer's Disease (AD) and provide a useful tool to characterize and predict the course of the disease. Those alterations have been also described in Mild Cognitive Impairment (MCI), a prodromal stage of AD. There is a growing interest in detecting AD pathology in the brain in the very early stages of the disorder. Subjective Cognitive Decline (SCD) could represent a preclinical asymptomatic stage of AD but very little is known about this population...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28482640/individual-correspondence-of-amyloid-%C3%AE-and-intrinsic-connectivity-in-the-posterior-default-mode-network-across-stages-of-alzheimer-s-disease
#5
Lorenzo Pasquini, Gloria Benson, Michel J Grothe, Lukas Utz, Nicholas E Myers, Igor Yakushev, Timo Grimmer, Martin Scherr, Christian Sorg
In Alzheimer's disease (AD), amyloid-β (Aβ) pathology and intrinsic functional connectivity (iFC) interact. Across stages of AD, we expected individual spatial correspondence of Aβ and iFC to reveal both Aβ accumulation and its detrimental effects on iFC. We used resting-state functional magnetic imaging and Aβ imaging in a cross-sectional sample of 90 subjects across stages of AD and healthy older adults. Global and local correspondence of Aβ and iFC were assessed within the posterior default mode network (pDMN) by within-subject voxel-wise correlations...
May 2, 2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28482212/the-frequency-and-influence-of-dementia-risk-factors-in-prodromal-alzheimer-s-disease
#6
Isabelle Bos, Stephanie J Vos, Lutz Frölich, Johannes Kornhuber, Jens Wiltfang, Wolfgang Maier, Oliver Peters, Eckhart Rüther, Sebastiaan Engelborghs, Ellis Niemantsverdriet, Ellen Elisa De Roeck, Magda Tsolaki, Yvonne Freund-Levi, Peter Johannsen, Rik Vandenberghe, Alberto Lleó, Daniel Alcolea, Giovanni B Frisoni, Samantha Galluzzi, Flavio Nobili, Silvia Morbelli, Alexander Drzezga, Mira Didic, Bart N van Berckel, Eric Salmon, Christine Bastin, Solene Dauby, Isabel Santana, Inês Baldeiras, Alexandre de Mendonça, Dina Silva, Anders Wallin, Arto Nordlund, Preciosa M Coloma, Angelika Wientzek, Myriam Alexander, Gerald P Novak, Mark Forrest Gordon, Åsa K Wallin, Harald Hampel, Hilkka Soininen, Sanna-Kaisa Herukka, Philip Scheltens, Frans R Verhey, Pieter Jelle Visser
We investigated whether dementia risk factors were associated with prodromal Alzheimer's disease (AD) according to the International Working Group-2 and National Institute of Aging-Alzheimer's Association criteria, and with cognitive decline. A total of 1394 subjects with mild cognitive impairment from 14 different studies were classified according to these research criteria, based on cognitive performance and biomarkers. We compared the frequency of 10 risk factors between the subgroups, and used Cox-regression to examine the effect of risk factors on cognitive decline...
April 8, 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28458232/cortisol-mediator-of-association-between-alzheimer-s-disease-and-diabetes-mellitus
#7
REVIEW
Elena Notarianni
Numerous epidemiologic studies have identified an independent association between Alzheimer's disease (AD) and diabetes mellitus (DM), which remains unexplained. This review contends that the association is mediated by mild hypercortisolemia that is manifested in AD by early stages, as empirical evidence indicates that hypercortisolemia is diabetogenic even at subclinical levels. Subclinical Cushing's syndrome is discussed as the paradigm. It is proposed that hypercortisolemia increases the risk of pre-diabetes and DM during early AD and the preceding decades...
April 23, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28453473/prodromal-dementia-with-lewy-bodies-and-prodromal-alzheimer-s-disease-a-comparison-of-the-cognitive-and-clinical-profiles
#8
Dilman Sadiq, Tim Whitfield, Lean Lee, Tim Stevens, Sergi Costafreda, Zuzana Walker
BACKGROUND: Dementia must be diagnosed accurately and early in the disease course to allow pathology-specific treatments to be effective. Dementia with Lewy bodies (DLB) is often misdiagnosed as Alzheimer's disease (AD), especially at the prodromal stage. OBJECTIVE: To compare the clinical and neuropsychological profiles of Mild Cognitive Impairment (MCI) patients who, at follow-up, progressed to AD (retrospectively AD-MCI) or DLB (retrospectively DLB-MCI) or remained MCI...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28435465/hypertension-cerebrovascular-impairment-and-cognitive-decline-in-aged-a%C3%AE-pp-ps1-mice
#9
Maximilian Wiesmann, Valerio Zerbi, Diane Jansen, Dieter Lütjohann, Andor Veltien, Arend Heerschap, Amanda J Kiliaan
Cardiovascular risk factors, especially hypertension, are also major risk factors for Alzheimer's disease (AD). To elucidate the underlying vascular origin of neurodegenerative processes in AD, we investigated the relation between systolic blood pressure (SBP) cerebral blood flow (CBF) and vasoreactivity with brain structure and function in a 16-18 months old double transgenic AβPPswe/PS1dE9 (AβPP/PS1) mouse model for AD. These aging AβPP/PS1 mice showed an increased SBP linked to a declined regional CBF...
2017: Theranostics
https://www.readbyqxmd.com/read/28428015/plasma-neurofilament-light-chain-levels-in-alzheimer-s-disease
#10
Wenjun Zhou, Jie Zhang, Fanlong Ye, Guangzheng Xu, Hang Su, Yindan Su, Xiangyang Zhang
Plasma neurofilament light (NFL) levels may be a marker of neuronal injury. We examined whether plasma NFL might be a potential biomarker for the prodromal and dementia stages of AD. Participants included 193 cognitively normal (CN), 198 amnestic mild cognitive impairment (aMCI) and 187 Alzheimer's disease (AD) individuals enrolled in the Alzheimer's Disease Neuroimaging Initiative (ADNI). Plasma NFL levels were examined by the Single Molecule array (Simoa) technique. Our results showed significantly increased plasma NFL levels in both AD (50...
April 18, 2017: Neuroscience Letters
https://www.readbyqxmd.com/read/28426384/a-2-year-old-boy-with-circulatory-failure-owing-to-streptococcal-toxic-shock-syndrome-case-report
#11
Werner Keenswijk, Johan Vande Walle
A 2-year-old boy presented with severe hypotension and acute kidney injury after a prodrome of non-bloody diarrhoea and fever in the preceding 3 days. He had a mild Ebstein cardiac anomaly but otherwise a normal past history and growth. On examination, he looked ill, his temperature was 37.5 °C, circulation was poor, and there were several purpuric lesions on the face, hands and scrotum. Haemoglobin was 7.8 g/dL (11-14), total white cell count 27 × 10(9)/L, platelets 62 × 10(9)/L, blood urea nitrogen 20...
April 20, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28414186/a-review-on-neuroimaging-based-classification-studies-and-associated-feature-extraction-methods-for-alzheimer-s-disease-and-its-prodromal-stages
#12
REVIEW
Saima Rathore, Mohamad Habes, Muhammad Aksam Iftikhar, Amanda Shacklett, Christos Davatzikos
Neuroimaging has made it possible to measure pathological brain changes associated with Alzheimer's disease (AD) in vivo. Over the past decade, these measures have been increasingly integrated into imaging signatures of AD by means of classification frameworks, offering promising tools for individualized diagnosis and prognosis. We reviewed neuroimaging-based studies for AD and mild cognitive impairment classification, selected after online database searches in Google Scholar and PubMed (January, 1985-June, 2016)...
April 13, 2017: NeuroImage
https://www.readbyqxmd.com/read/28410856/regional-18f-fluorodeoxyglucose-hypometabolism-is-associated-with-higher-apathy-scores-over-time-in-early-alzheimer-disease
#13
Jennifer R Gatchel, Nancy J Donovan, Joseph J Locascio, J Alex Becker, Dorene M Rentz, Reisa A Sperling, Keith A Johnson, Gad A Marshall
OBJECTIVES: Apathy is among the earliest and most pervasive neuropsychiatric symptoms in prodromal and mild Alzheimer disease (AD) dementia that correlates with functional impairment and disease progression. We investigated the association of apathy with regional 18F-fluorodeoxyglucose (FDG) metabolism in cognitively normal, mild cognitive impairment, and AD dementia subjects from the Alzheimer's Disease Neuroimaging Initiative database. DESIGN: Cross-sectional and longitudinal studies...
January 4, 2017: American Journal of Geriatric Psychiatry
https://www.readbyqxmd.com/read/28410658/the-role-of-neuroimaging-in-the-assessment-of-the-cognitively-impaired-elderly
#14
REVIEW
Sara Kollack-Walker, Collin Y Liu, Adam S Fleisher
This article reviews the current diagnostic tools that are available for structural, functional, and molecular imaging of the brain, summarizing some of the key findings that have been reported in individuals diagnosed with Alzheimer disease, mild cognitive impairment, prodromal AD, or other prevalent dementias. Given recent advances in the development of amyloid PET tracers, current guidelines for the use of amyloid PET imaging in patients with cognitive complaints are reviewed. In addition, data addressing the potential value of amyloid PET imaging in the clinical setting are highlighted...
May 2017: Neurologic Clinics
https://www.readbyqxmd.com/read/28408865/tau-pathology-distribution-in-alzheimer-s-disease-corresponds-differentially-to-cognition-relevant-functional-brain-networks
#15
Oskar Hansson, Michel J Grothe, Tor Olof Strandberg, Tomas Ohlsson, Douglas Hägerström, Jonas Jögi, Ruben Smith, Michael Schöll
Neuropathological studies have shown that the typical neurofibrillary pathology of hyperphosphorylated tau protein in Alzheimer's disease (AD) preferentially affects specific brain regions whereas others remain relatively spared. It has been suggested that the distinct regional distribution profile of tau pathology in AD may be a consequence of the intrinsic network structure of the human brain. The spatially distributed brain regions that are most affected by the spread of tau pathology may hence reflect an interconnected neuronal system...
2017: Frontiers in Neuroscience
https://www.readbyqxmd.com/read/28388490/hospital-treated-mental-and-behavioral-disorders-and-risk-of-alzheimer-s-disease-a-nationwide-nested-case-control-study
#16
V Tapiainen, S Hartikainen, H Taipale, J Tiihonen, A-M Tolppanen
BACKGROUND: Studies investigating psychiatric disorders as Alzheimer's disease (AD) risk factors have yielded heterogeneous findings. Differences in time windows between the exposure and outcome could be one explanation. We examined whether (1) mental and behavioral disorders in general or (2) specific mental and behavioral disorder categories increase the risk of AD and (3) how the width of the time window between the exposure and outcome affects the results. METHODS: A nationwide nested case-control study of all Finnish clinically verified AD cases, alive in 2005 and their age, sex and region of residence matched controls (n of case-control pairs 27,948)...
March 9, 2017: European Psychiatry: the Journal of the Association of European Psychiatrists
https://www.readbyqxmd.com/read/28373857/alzheimer-s-disease-biomarkers-in-the-genome-blood-and-cerebrospinal-fluid
#17
REVIEW
Rose Ann Huynh, Chandra Mohan
Alzheimer's disease (AD) is a progressive neurodegenerative disorder that slowly destroys memory and thinking skills, resulting in behavioral changes. It is estimated that nearly 36 million are affected globally with numbers reaching 115 million by 2050. AD can only be definitively diagnosed at autopsy since its manifestations of senile plaques and neurofibrillary tangles throughout the brain cannot yet be fully captured with current imaging technologies. Current AD therapeutics have also been suboptimal. Besides identifying markers that distinguish AD from controls, there has been a recent drive to identify better biomarkers that can predict the rates of cognitive decline and neocortical amyloid burden in those who exhibit preclinical, prodromal, or clinical AD...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28372331/biomarkers-and-functional-decline-in%C3%A2-prodromal-alzheimer-s-disease
#18
Catherine Robb, Chinedu Udeh-Momoh, Stefan Wagenpfeil, Jakob Schöpe, Panagiotis Alexopoulos, Robert Perneczky
BACKGROUND: Little is known of possible associations between Alzheimer's disease (AD) biomarkers and instrumental activities of daily living (IADL) change over time. OBJECTIVE: The present study seeks to identify relationships between baseline imaging and fluid biomarker profiles, and decline in IADL utilizing data collated from the Alzheimer's Disease Neuroimaging Initiative (ADNI) cohort. METHODS: Generalized estimating equations analysis, adjusted for cognitive deterioration, was applied to a cohort of 509 individuals from all stages of ADNI, including 156 healthy controls, 189 early mild cognitive impairment (MCI) patients and 164 MCI patients...
2017: Journal of Alzheimer's Disease: JAD
https://www.readbyqxmd.com/read/28365005/neocortical-and-hippocampal-trem2-protein-levels-during-the-progression-of-alzheimer-s-disease
#19
Sylvia E Perez, Muhammad Nadeem, Bin He, Jennifer C Miguel, Michael H Malek-Ahmadi, Kewei Chen, Elliott J Mufson
Heterozygous triggering receptor expressed on myeloid cells (TREM2) mutations are an Alzheimer's disease (AD) risk factor. Nonmutated TREM2 dysregulation occurs in AD brain. Whether TREM2 is altered in prodromal AD remains unknown. Western blotting was used to determine levels of TREM2 (∼25 kDa) and Iba1 in the frontal cortex and TREM2 in the hippocampus from people who died with an ante-mortem clinical diagnosis of non- and mild-cognitive impairment, mild/moderate AD, and severe AD (sAD). Immunohistochemistry defined the relationship between amyloid and Iba1 profiles...
June 2017: Neurobiology of Aging
https://www.readbyqxmd.com/read/28359566/increased-plasma-beta-secretase-1-may-predict-conversion-to-alzheimer-s-disease-dementia-in-individuals-with-mild-cognitive-impairment
#20
Yong Shen, Haibo Wang, Qiying Sun, Hailan Yao, Andrew P Keegan, Mike Mullan, Jeffrey Wilson, Simone Lista, Thomas Leyhe, Christoph Laske, Dan Rujescu, Allan Levey, Anders Wallin, Kaj Blennow, Rena Li, Harald Hampel
BACKGROUND: Increased beta-secretase 1 (BACE1) activity has consistently been detected in brain tissue and cerebrospinal fluid of subjects with mild cognitive impairment (MCI) and probable Alzheimer's disease (AD) compared with control subjects. The collection of cerebrospinal fluid by lumbar puncture is invasive. We sought to identify the presence of plasma BACE1 activity and determine potential alterations in subjects with MCI with clinical follow-up examinations for 3 years using patients with diagnosed probable AD dementia compared with healthy control subjects...
March 27, 2017: Biological Psychiatry
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