Paweł Nakielski, Daniel Rybak, Katarzyna Jezierska-Woźniak, Chiara Rinoldi, Emilia Sinderewicz, Joanna Staszkiewicz-Chodor, Mohammad Ali Haghighat Bayan, Wioleta Czelejewska, Olga Urbanek, Alicja Kosik-Kozioł, Monika Barczewska, Mateusz Skomorowski, Piotr Holak, Seweryn Lipiński, Wojciech Maksymowicz, Filippo Pierini
Current treatments of degenerated intervertebral discs often provide only temporary relief or address specific causes, necessitating the exploration of alternative therapies. Cell-based regenerative approaches showed promise in many clinical trials, but limitations such as cell death during injection and a harsh disk environment hinder their effectiveness. Injectable microscaffolds offer a solution by providing a supportive microenvironment for cell delivery and enhancing bioactivity. This study evaluated the safety and feasibility of electrospun nanofibrous microscaffolds modified with chitosan (CH) and chondroitin sulfate (CS) for treating degenerated NP tissue in a large animal model...
November 29, 2023: ACS Applied Materials & Interfaces