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https://www.readbyqxmd.com/read/29343508/circular-rna-vma21-protects-against-intervertebral-disc-degeneration-through-targeting-mir-200c-and-x-linked-inhibitor-of-apoptosis-protein
#1
Xiaofei Cheng, Liang Zhang, Kai Zhang, Guoying Zhang, Ying Hu, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zhao
OBJECTIVES: Circular RNAs (circRNAs) have been proven to function as competing endogenous RNAs to interact with microRNAs (miRNAs) and influence the expression of miRNA target mRNAs. In this study, we investigated whether circRNAs could act as competing endogenous RNAs to regulate the pathological process of intervertebral disc degeneration (IVDD). METHODS: The role and mechanism of a circRNA, circVMA21, in IVDD were explored in nucleus pulposus (NP) cells and degenerative NP tissues from patients and rat models...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29320615/an-intervertebral-disc-whole-organ-culture-system-to-investigate-proinflammatory-and-degenerative-disc-disease-condition
#2
Gernot Lang, Yishan Liu, Janna Geries, Zhiyu Zhou, David Kubosch, Norbert Südkamp, R Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li
OBJECTIVE: The aim of this study was to compare the effect of different disease initiators of degenerative disc disease (DDD) within an intervertebral disc (IVD) organ culture system, and to understand the interplay between inflammation and degeneration in the early stage of DDD. DESIGN: Bovine caudal IVDs were cultured within a bioreactor for up to 11 days. Control group was cultured under physiological loading (0.02-0.2 MPa; 0.2 Hz; 2h/day) and high glucose (4...
January 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29310946/validation-of-lumbar-spine-loading-from-a-musculoskeletal-model-including-the-lower-limbs-and-lumbar-spine
#3
Jason A Actis, Jasmin D Honegger, Deanna H Gates, Anthony J Petrella, Luis A Nolasco, Anne K Silverman
Low back mechanics are important to quantify to study injury, pain and disability. As in vivo forces are difficult to measure directly, modeling approaches are commonly used to estimate these forces. Validation of model estimates is critical to gain confidence in modeling results across populations of interest, such as people with lower-limb amputation. Motion capture, ground reaction force and electromyographic data were collected from ten participants without an amputation (five male/five female) and five participants with a unilateral transtibial amputation (four male/one female) during trunk-pelvis range of motion trials in flexion/extension, lateral bending and axial rotation...
December 13, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29191100/preliminary-results-of-anterior-lumbar-interbody-fusion-anterior-column-realignment-for-the-treatment-of-sagittal-malalignment
#4
Pooria Hosseini, Gregory M Mundis, Robert K Eastlack, Ramin Bagheri, Enrique Vargas, Stacie Tran, Behrooz A Akbarnia
OBJECTIVE Sagittal malalignment decreases patients' quality of life and may require surgical correction to achieve realignment goals. High-risk posterior-based osteotomy techniques are the current standard treatment for addressing sagittal malalignment. More recently, anterior lumbar interbody fusion, anterior column realignment (ALIF ACR) has been introduced as an alternative for correction of sagittal deformity. The objective of this paper was to report clinical and radiographic results for patients treated using the ALIF-ACR technique...
December 2017: Neurosurgical Focus
https://www.readbyqxmd.com/read/29186157/finite-element-simulation-and-clinical-follow-up-of-lumbar-spine-biomechanics-with-dynamic-fixations
#5
Yolanda Más, Luis Gracia, Elena Ibarz, Sergio Gabarre, Diego Peña, Antonio Herrera
Arthrodesis is a recommended treatment in advanced stages of degenerative disc disease. Despite dynamic fixations were designed to prevent abnormal motions with better physiological load transmission, improving lumbar pain and reducing stress on adjacent segments, contradictory results have been obtained. This study was designed to compare differences in the biomechanical behaviour between the healthy lumbar spine and the spine with DYNESYS and DIAM fixation, respectively, at L4-L5 level. Behaviour under flexion, extension, lateral bending and axial rotation are compared using healthy lumbar spine as reference...
2017: PloS One
https://www.readbyqxmd.com/read/29180112/mri-evaluation-of-the-effects-of-extension-exercises-on-the-disc-fluid-content-and-location-of-the-centroid-of-the-fluid-distribution
#6
Vahid Abdollah, Eric C Parent, Michele C Battié
BACKGROUND: McKenzie prone press-up exercises have been hypothesised to reduce intradiscal pressure, allowing fluid to be reabsorbed into the disc, which could improve the internal stability and local chemical milieu of the disc, potentially reducing symptoms. OBJECTIVE: To investigate the immediate effects of prone press-up exercises on lumbar disc fluid content and movement. DESIGN: Quantification of MRI changes before and after a single exercise session...
November 21, 2017: Musculoskeletal Science & Practice
https://www.readbyqxmd.com/read/29160423/comparison-of-short-segment-monoaxial-and-polyaxial-pedicle-screw-fixation-combined-with-intermediate-screws-in-traumatic-thoracolumbar-fractures-a-finite-element-study-and-clinical-radiographic-review
#7
Hongwei Wang, Yiwen Zhao, Zhongjun Mo, Jianda Han, Yu Chen, Hailong Yu, Qi Wang, Jun Liu, Changqing Li, Yue Zhou, Liangbi Xiang
OBJECTIVES: No studies have compared monoaxial and polyaxial pedicle screws with regard to the von Mises stress of the instrumentation, intradiscal pressures of the adjacent segment and adjacent segment degeneration. METHODS: Short-segment monoaxial/polyaxial pedicle screw fixation techniques were compared using finite element methods, and the redistributed T11-L1 segment range of motion, largest maximal von Mises stress of the instrumentation, and intradiscal pressures of the adjacent segment under displacement loading were evaluated...
October 2017: Clinics
https://www.readbyqxmd.com/read/29153706/load-sharing-in-the-lumbosacral-spine-in-neutral-standing-flexed-postures-a-combined-finite-element-and-inverse-static-study
#8
Tao Liu, Kinda Khalaf, Sadegh Naserkhaki, Marwan El-Rich
Understanding load-sharing in the spine during in-vivo conditions is critical for better spinal implant design and testing. Previous studies of load-sharing that considered actual spinal geometry applied compressive follower load, with or without moment, to simulate muscle forces. Other studies used musculoskeletal models, which include muscle forces, but model the discs by simple beams or spherical joints and ignore the articular facet joints. This study investigated load-sharing in neutral standing and flexed postures using a detailed Finite Element (FE) model of the ligamentous lumbosacral spine, where muscle forces, gravity loads and intra-abdominal pressure, as predicted by a musculoskeletal model of the upper body, are input into the FE model...
November 6, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29141662/safety-and-tolerability-of-intradiscal-implantation-of-combined-autologous-adipose-derived-mesenchymal-stem-cells-and-hyaluronic-acid-in-patients-with-chronic-discogenic-low-back-pain-1-year-follow-up-of-a-phase-i-study
#9
Hemant Kumar, Doo-Hoe Ha, Eun-Jong Lee, Jun Hee Park, Jeong Hyun Shim, Tae-Keun Ahn, Kyoung-Tae Kim, Alexander E Ropper, Seil Sohn, Chung-Hun Kim, Devang Kashyap Thakor, Soo-Hong Lee, In-Bo Han
BACKGROUND: Adipose tissue-derived mesenchymal stem cells (AT-MSCs) offer potential as a therapeutic option for chronic discogenic low back pain (LBP) because of their immunomodulatory functions and capacity for cartilage differentiation. The goal of this study was to assess the safety and tolerability of a single intradiscal implantation of combined AT-MSCs and hyaluronic acid (HA) derivative in patients with chronic discogenic LBP. METHODS: We performed a single-arm phase I clinical trial with a 12-month follow-up and enrolled 10 eligible chronic LBP patients...
November 15, 2017: Stem Cell Research & Therapy
https://www.readbyqxmd.com/read/29128087/-platelet-rich-plasma-prp-and-disc-lesions-a-review-of-the-literature
#10
REVIEW
L Charneux, C Demoulin, M Vanderthomment, M Tomasella, M-A Ferrara, S Grosdent, S Bethlen, R Fontaine, P Gillet, T Racaru, J-F Kaux
The spine has been the subject of extensive clinical research since it is the source of many painful complaints. However, there is little scientific evidence concerning the therapeutic proposals. During the course of life, the intervertebral disc degenerates, which over time diminishes its damping capacity and facilitates the expulsion of the nucleus pulposus through the annulus fibrosus. The degeneration of the intervertebral disc (DDI) is the origin of some back pain and various specific treatments have been developed...
November 8, 2017: Neuro-Chirurgie
https://www.readbyqxmd.com/read/29106896/the-rib-cage-reduces-intervertebral-disc-pressures-in-cadaveric-thoracic-spines-by-sharing-loading-under-applied-dynamic-moments
#11
Dennis E Anderson, Erin M Mannen, Rebecca Tromp, Benjamin M Wong, Hadley L Sis, Eileen S Cadel, Elizabeth A Friis, Mary L Bouxsein
The effects of the rib cage on thoracic spine loading are not well studied, but the rib cage may provide stability or share loads with the spine. Intervertebral disc pressure provides insight into spinal loading, but such measurements are lacking in the thoracic spine. Thus, our objective was to examine thoracic intradiscal pressures under applied pure moments, and to determine the effect of the rib cage on these pressures. Human cadaveric thoracic spine specimens were positioned upright in a testing machine, and Dynamic pure moments (0 to ±5 N·m) with a compressive follower load of 400 N were applied in axial rotation, flexion - extension, and lateral bending...
October 12, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/29092070/radiopaque-gelified-ethanol-application-in-lumbar-intervertebral-soft-disc-herniations-croatian-multicentric-study
#12
Karlo Houra, Darko Perovic, Ivan Rados, Drazen Kvesic
Objective: Minimally invasive percutaneous spinal procedures are popular in trying to reduce spinal pain. The aim of this paper is to evaluate the safety of intervertebral disc chemonucleolysis and to report the effectiveness of a percutaneous, minimally invasive treatment for contained herniated intervertebral discs in the lumbar spine using the recently marketed radiopaque gelified ethanol. Methods: Pain relief before and after the procedure was self-evaluated by each patient using a verbal numeric scale (VNS) ranging from 0 to 10...
October 28, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/29080003/percutaneous-posterolateral-approach-for-the-simulation-of-a-far-lateral-disc-herniation-in-an-ovine-model
#13
Stefan Schwan, Christopher Ludtka, Ingo Wiesner, Andre Baerthel, Andrea Friedmann, Felix Göhre
PURPOSE: This work describes a minimally invasive damage model for ovine lumbar discs via partial nucleotomy using a posterolateral approach. METHODS: Two cadavers were dissected to analyze the percutaneous corridor. Subsequently, 28 ovine had their annulus fibrosus punctured via awl penetration under fluoroscopic control and nucleus pulposus tissue removed via rongeur. Efficacy was assessed by animal morbidity, ease of access to T12-S1 disc spaces, and production of a mechanical injury as verified by discography, radiography, and histology...
October 27, 2017: European Spine Journal
https://www.readbyqxmd.com/read/29065672/the-effects-of-physiological-biomechanical-loading-on-intradiscal-pressure-and-annulus-stress-in-lumbar-spine-a-finite-element-analysis
#14
Siti Nurfaezah Zahari, Mohd Juzaila Abd Latif, Nor Raihanah Abdull Rahim, Mohammed Rafiq Abdul Kadir, Tunku Kamarul
The present study was conducted to examine the effects of body weight on intradiscal pressure (IDP) and annulus stress of intervertebral discs at lumbar spine. Three-dimensional finite element model of osseoligamentous lumbar spine was developed subjected to follower load of 500 N, 800 N, and 1200 N which represent the loads for individuals who are normal and overweight with the pure moments at 7.5 Nm in flexion and extension motions. It was observed that the maximum IDP was 1.26 MPa at L1-L2 vertebral segment...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065645/effect-of-graded-facetectomy-on-lumbar-biomechanics
#15
Zhi-Li Zeng, Rui Zhu, Yang-Chun Wu, Wei Zuo, Yan Yu, Jian-Jie Wang, Li-Ming Cheng
Facetectomy is an important intervention for spinal stenosis but may lead to spinal instability. Biomechanical knowledge for facetectomy can be beneficial when deciding whether fusion is necessary. Therefore, the aim of this study was to investigate the biomechanical effect of different grades of facetectomy. A three-dimensional nonlinear finite element model of L3-L5 was constructed. The mobility of the model and the intradiscal pressure (IDP) of L4-L5 for standing were inside the data from the literature...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29065628/the-effect-of-lumbar-disc-herniation-on-spine-loading-characteristics-during-trunk-flexion-and-two-types-of-picking-up-activities
#16
Shengzheng Kuai, Weiqiang Liu, Run Ji, Wenyu Zhou
The main purpose of this study was to investigate the compensatory response of the muscle activities of seventeen major muscle groups in the spinal region, intradiscal forces of the five lumbar motion segment units (MSUs), and facet forces acting on the ten lumbar facet joints in patients with lumbar disc herniation (LDH). Twenty-six healthy adults and seven LDH patients performed trunk flexion, ipsilateral picking up, and contralateral picking up in sequence. Eight optical markers were placed on the landmarks of the pelvis and spinal process...
2017: Journal of Healthcare Engineering
https://www.readbyqxmd.com/read/29038672/safety-analysis-of-autologous-stem-cell-therapy-in-a-variety-of-degenerative-diseases-and-injuries-using-the-stromal-vascular-fraction
#17
Kristin Comella, Michelle Parlo, Rosemary Daly, Vincent Depasquale, Eric Edgerton, Patrick Mallory, Roy Schmidt, Walter P Drake
BACKGROUND: Stem cells from adipose tissue offer a novel therapy for patients with damaged tissue. Stromal vascular fraction (SVF) injected into patients may reduce inflammation, promote healing, and repair damaged/scarred tissue. SVF can be isolated from fat (adipose) tissue in an outpatient procedure. The SVF population includes mesenchymal stem cells (MSCs), pericytes, endothelial/progenitor cells, fibroblasts and growth factors where the adipocyte (fat cell) population has been removed...
November 2017: Journal of Clinical Medicine Research
https://www.readbyqxmd.com/read/29019902/in-vitro-biomechanical-comparison-after-fixed-and-mobile-core-artificial-cervical-disc-replacement-versus-fusion
#18
COMPARATIVE STUDY
Jigang Lou, Yuanchao Li, Beiyu Wang, Yang Meng, Tingkui Wu, Hao Liu
In vitro biomechanical analysis after cervical disc replacement (CDR) with a novel artificial disc prosthesis (mobile core) was conducted and compared with the intact model, simulated fusion, and CDR with a fixed-core prosthesis. The purpose of this experimental study was to analyze the biomechanical changes after CDR with a novel prosthesis and the differences between fixed- and mobile-core prostheses.Six human cadaveric C2-C7 specimens were biomechanically tested sequentially in 4 different spinal models: intact specimens, simulated fusion, CDR with a fixed-core prosthesis (Discover, DePuy), and CDR with a mobile-core prosthesis (Pretic-I, Trauson)...
October 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28958435/increased-spinal-height-using-propped-slouched-sitting-postures-innovative-ways-to-rehydrate-intervertebral-discs
#19
John L Pape, Jean-Michel Brismée, Phillip S Sizer, Omer C Matthijs, Kevin L Browne, Birendra M Dewan, Stéphane Sobczak
BACKGROUND: Upright and slouched sitting are frequently adopted postures associated with increased intradiscal pressure, spinal height loss and intervertebral disc pathology. OBJECTIVES: To examine the effects of two sustained propped slouched sitting (PSS) postures on spinal height after a period of trunk loading. METHODS: Thirty-four participants without a history of low back pain (LBP) were recruited (age 24.4 ± 1.6 years). Subjects sat in (1) PSS without lumbar support and (2) PSS with lumbar support for 10 min, after a period of trunk loading...
January 2018: Applied Ergonomics
https://www.readbyqxmd.com/read/28952779/clinical-outcome-and-subsequent-sequelae-of-cement-extravasation-after-percutaneous-kyphoplasty-and-vertebroplasty-a-comparative-review
#20
Hassan Semaan, Tawfik Obri, Mohamad Bazerbashi, Daniel Paull, Xiaochen Liu, Marah Sarrouj, Hossein Elgafy
Background Injection of cement during vertebroplasty and kyphoplasty can leak into surrounding structures and could be symptomatic. Purpose To identify the sites and incidence of cement extravasation after kyphoplasty and vertebroplasty, and to evaluate their impacts on clinical outcomes. Material and Methods A retrospective review of 316 patients treated with kyphoplasty and vertebroplasty; 411 cases were included (223 kyphoplasty and 188 vertebroplasty). Cement extravasation was evaluated postoperatively by computed tomography (CT) scan of the spine...
January 1, 2017: Acta Radiologica
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