keyword
MENU ▼
Read by QxMD icon Read
search

intradiscal

keyword
https://www.readbyqxmd.com/read/29758454/biomechanical-investigation-on-the-influence-of-the-regional-material-degeneration-of-an-intervertebral-disc-in-a-lower-lumbar-spinal-unit-a-finite-element-study
#1
Masni-Azian, Masao Tanaka
Intervertebral disc degeneration involves changes in its material properties that affect the mechanical functions of the spinal system. However, the alteration of the biomechanics of a spinal segment through specific material degradation in a specific region is poorly understood. In this study, the influence of the constitutive material degeneration of disc tissues on the mechanics of a lower lumbar spinal unit was examined using a three-dimensional nonlinear finite element model of the L4-L5 functional spinal unit...
May 6, 2018: Computers in Biology and Medicine
https://www.readbyqxmd.com/read/29729693/intradiscal-ozone-therapy-for-lumbar-disc-herniation
#2
Sibel Ozcan, Arzu Muz, Aysun Yildiz Altun, Selami Ates Onal
The rationale behind intradiscal O2-O3 therapy is the pain elicited by the mechanical compression of the nerve root, which is associated with periganglionic and periradicular inflammation. This study aimed to determine the effect of intradiscal ozone injection on pain score and satisfaction of patients with low back pain (LBP) secondary to disc herniation. Patients with LBP diagnosed with disc herniation were enrolled in this clinical trial. After prepping and draping the area, intradiscal injection of ozone/oxygen mixture (10 ml, 25μg/ml) was performed under fluoroscopy guide (c-arm)...
April 30, 2018: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/29668635/effect-of-intradiscal-pulsed-radiofrequency-on-refractory-chronic-discogenic-neck-pain-a-case-report
#3
So Young Kwak, Min Cheol Chang
RATIONALE: Despite medication, exercise, and medical intervention, many patients complain of persistent discogenic neck pain. To manage discogenic neck pain, we performed intradiscal pulsed radiofrequency (PRF) stimulation in a patient with chronic discogenic neck pain refractory to oral medication and epidural steroid injection. PATIENT CONCERNS: A 26-year-old man presented with a numeric rating scale (NRS) score of 7 for chronic neck pain. His pain was worse when the neck was held in one position for a prolonged period...
April 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29605701/the-role-of-posterior-screw-fixation-in-single-level-transforaminal-lumbar-interbody-fusion-during-whole-body-vibration-a-finite-element-study
#4
Wei Fan, Li-Xin Guo
OBJECTIVE: Very few studies have evaluated the need for supplementary instrumentation after lumbar interbody fusion under the condition of whole body vibration (WBV) that is typically present in vehicles. This study aimed to determine the effect of posterior pedicle screw fixation on dynamic response of the whole lumbar spine to vertical WBV after transforaminal lumbar interbody fusion (TLIF). METHODS: A previously validated non-linear, osteoligamentous finite element (FE) model of the intact L1-sacrum human lumbar spine was modified to simulate single-level (L4-L5) TLIF without and with bilateral pedicle screw fixation (BPSF)...
March 29, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29584512/acute-prevertebral-abscess-secondary-to-intradiscal-oxygen-ozone-chemonucleolysis-for-treatment-of-a-cervical-disc-herniation
#5
Chun-Sheng Yang, Lin-Jie Zhang, Zhi-Hua Sun, Li Yang, Fu-Dong Shi
Objective We herein present a case involving a prevertebral abscess complicated by a spinal epidural abscess (SEA) secondary to intradiscal oxygen-ozone chemonucleolysis for treatment of a cervical disc herniation. Methods A 67-year-old woman with a history of intradiscal oxygen-ozone chemonucleolysis developed numbness and weakness in her right upper and bilateral lower extremities followed by urinary retention. Her symptoms did not respond to intravenous antibiotics alone. Magnetic resonance imaging of the cervical region revealed an extensive SEA anterior to the spinal cord, spinal cord myelopathy due to anterior compression by the lesion, and a prevertebral abscess extending from C2 to T1...
January 1, 2018: Journal of International Medical Research
https://www.readbyqxmd.com/read/29555765/ligand-channel-in-pharmacologically-stabilized-rhodopsin
#6
Daniel Mattle, Bernd Kuhn, Johannes Aebi, Marc Bedoucha, Demet Kekilli, Nathalie Grozinger, Andre Alker, Markus G Rudolph, Georg Schmid, Gebhard F X Schertler, Michael Hennig, Jörg Standfuss, Roger J P Dawson
In the degenerative eye disease retinitis pigmentosa (RP), protein misfolding leads to fatal consequences for cell metabolism and rod and cone cell survival. To stop disease progression, a therapeutic approach focuses on stabilizing inherited protein mutants of the G protein-coupled receptor (GPCR) rhodopsin using pharmacological chaperones (PC) that improve receptor folding and trafficking. In this study, we discovered stabilizing nonretinal small molecules by virtual and thermofluor screening and determined the crystal structure of pharmacologically stabilized opsin at 2...
April 3, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29511680/the-effect-of-muscle-direction-on-the-predictions-of-finite-element-model-of-human-lumbar-spine
#7
Rui Zhu, Wen-Xin Niu, Zhi-Peng Wang, Xiao-Long Pei, Bin He, Zhi-Li Zeng, Li-Ming Cheng
The normal physiological loads from muscles experienced by the spine are largely unknown due to a lack of data. The aim of this study is to investigate the effects of varying muscle directions on the outcomes predicted from finite element models of human lumbar spine. A nonlinear finite element model of L3-L5 was employed. The force of the erector spinae muscle, the force of the rectus abdominis muscle, follower loads, and upper body weight were applied. The model was fixed in a neural standing position and the direction of the force of the erector spinae muscle and rectus abdominis muscle was varied in three directions...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29482611/biomechanical-evaluation-of-cervical-disc-replacement-with-a-novel-prosthesis-based-on-the-physiological-curvature-of-endplate
#8
Jigang Lou, Yuanchao Li, Beiyu Wang, Yang Meng, Quan Gong, Hao Liu
BACKGROUND: Most of the current available cervical disc prostheses present a flat surface instead of an arcuate surface which is most similar to the morphology of cervical endplate. Therefore, we designed a novel prosthesis (Pretic-I, Trauson) based on the physiological curvature of the cervical endplate. Biomechanical evaluation of cervical disc replacement (CDR) with this novel prosthesis was performed and compared with the Prestige LP prosthesis. METHODS: Three motion segments of 18 cadaveric cervical specimens (C2-C7) were evaluated with a 75 N follower load...
February 27, 2018: Journal of Orthopaedic Surgery and Research
https://www.readbyqxmd.com/read/29477002/effect-of-lumbar-lordosis-on-the-adjacent-segment-in-transforaminal-lumbar-interbody-fusion-a-finite-element-analysis
#9
Xin Zhao, Lin Du, Youzhuan Xie, Jie Zhao
OBJECTIVE: We used a finite element (FE) analysis to investigate the biomechanical changes caused by transforaminal lumbar interbody fusion (TLIF) at the L4-L5 level by lumbar lordosis (LL) degree. METHODS: A lumbar FE model (L1-S5) was constructed based on computed tomography scans of a 30-year-old healthy male volunteer (pelvic incidence,= 50°; LL, 52°). We investigated the influence of LL on the biomechanical behavior of the lumbar spine after TLIF in L4-L5 fusion models with 57°, 52°, 47°, and 40° LL...
February 21, 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29462729/the-influence-of-artificial-cervical-disc-prosthesis-height-on-the-cervical-biomechanics-a-finite-element-study
#10
Wei Yuan, Haiping Zhang, Xiaoshu Zhou, Weidong Wu, Yue Zhu
OBJECTIVE: Artificial cervical disc replacement is expected to maintain normal cervical biomechanics. At present, the effect of the Prestige LP prosthesis height on cervical biomechanics has not been thoroughly studied. This finite element study of the cervical biomechanics aims to predict how the parameters, like range of motion (ROM), adjacent intradiscal pressure, facet joint force, and bone-implant interface stress, are affected by different heights of Prestige LP prostheses. METHODS: The finite element model of intact cervical spine (C3-C7) was obtained from our previous study, and the model was altered to implant Prestige LP prostheses at the C5-C6 level...
May 2018: World Neurosurgery
https://www.readbyqxmd.com/read/29456918/cervical-disc-arthroplasty-a-comprehensive-review-of-single-level-multilevel-and-hybrid-procedures
#11
REVIEW
Joseph L Laratta, Jamal N Shillingford, Comron Saifi, K Daniel Riew
Study Design: Systematic review. Objectives: Degenerative disc disease and spondylosis resulting in radiculopathy and retrodiscal myelopathy are among the most frequently encountered cervical spinal disorders. Traditionally, anterior cervical discectomy and fusion (ACDF) has successfully achieved neural decompression and restored intradiscal height in these conditions. Unfortunately, nonunion and iatrogenic adjacent segment pathology associated with fusion procedures in the cervical spine has led to an interest in motion-preserving procedures...
February 2018: Global Spine Journal
https://www.readbyqxmd.com/read/29397111/biomechanical-response-of-intact-degenerated-and-repaired-intervertebral-discs-under-impact-loading-ex-vivo-and-in-silico-investigation
#12
Mohammad Nikkhoo, Jaw-Lin Wang, Mohamad Parnianpour, Marwan El-Rich, Kinda Khalaf
Understanding the effect of impact loading on the mechanical response of the intervertebral disc (IVD) is valuable for investigating injury mechanisms and devising effective therapeutic modalities. This study used 24 porcine thoracic motion segments to characterize the mechanical response of intact (N = 8), degenerated (Trypsin-denatured, N = 8), and repaired (Genepin-treated, N = 8) IVDs subject to impact loading. A meta-model analysis of poroelastic finite element simulations was used in combination with ex-vivo creep and impact tests to extract the material properties...
March 21, 2018: Journal of Biomechanics
https://www.readbyqxmd.com/read/29392289/finite-element-study-to-evaluate-the-biomechanical-performance-of-the-spine-after-augmenting-percutaneous-pedicle-screw-fixation-with-kyphoplasty-in-the-treatment-of-burst-fractures
#13
Shady S Elmasry, Shihab S Asfour, Francesco Travascio
Percutaneous pedicle screw fixation (PPSF) is a well-known minimally invasive surgery (MIS) employed in the treatment of thoracolumbar burst fractures (TBF). However, hardware failure and loss of angular correction are common limitations caused by the poor support of the anterior column of the spine. Balloon kyphoplasty (KP) is another MIS that was successfully used in the treatment of compression fractures by augmenting the injured vertebral body with cement. To overcome the limitations of stand-alone PPSF, it was suggested to augment PPSF with KP as a surgical treatment of TBF...
June 1, 2018: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/29375000/intradiscal-expandable-balloon-distraction-during-transforaminal-decompression-for-lumbar-foraminal-and-lateral-recess-stenosis
#14
Kai-Uwe Lewandrowski, Mathias Ostergren, Paulo Sergio Teixera de Carvalho
Advanced videoendoscopic equipment (such as motorized drills, chisels, and rongeurs) facilitates the use of modern decompression tools through the inner working channel of the spinal endoscope using the transforaminal approach. Postoperative dysesthetic leg pain, however, is common because of irritation of the dorsal root ganglion. This article presents a novel surgical technique employing an expandable balloon placed into the hollow intervertebral space in patients without any functional disc tissue to distract the stenotic motion segment...
April 2018: Surgical Innovation
https://www.readbyqxmd.com/read/29367664/prolactin-inhibits-the-progression-of-intervertebral-disc-degeneration-through-inactivation-of-the-nf-%C3%AE%C2%BAb-pathway-in-rats
#15
Xiexing Wu, Yu Liu, Xiaobin Guo, Wei Zhou, Liangliang Wang, Jiawei Shi, Yunxia Tao, Mo Zhu, Dechun Geng, Huilin Yang, Haiqing Mao
Intervertebral disc degeneration (IVDD) is one of the key predisposing factors for low back pain. Although the exact mechanism remains unclear, inflammatory response and nucleus pulposus (NP) apoptosis are known to play important roles in this process. Prolactin protects against inflammation-associated chondrocyte apoptosis in arthritis. Based on prior studies, we hypothesized that prolactin might have therapeutic effects on IVDD by inhibiting the apoptosis of degenerative human disc NP cells. An experimental model of IVDD was established in 3-month-old Sprague-Dawley rats by submitting them to percutaneous disc puncture with a 20-gauge needle on levels 7-8 and 8-9 of the coccygeal vertebrae...
January 24, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29357343/long-term-clinical-effects-of-discogel-for-cervical-disc-herniation
#16
Havva Sayhan, Serbülent Gökhan Beyaz, Ali Metin Ülgen, Mehmet Fatih Yuce, Yakup Tomak
BACKGROUND: Radiopaque gelified ethanol (RGE; DiscoGel, Gelscom SAS, France) is used as a chemonucleolysis substance in treating intradiscal herniation, showing good results without complications. It has also been used in cervical disc herniations (CDHs), demonstrating the potential efficacy of this substance. OBJECTIVE: The aim of the study is to investigate the long-term effectiveness and safety of DiscoGel in patients with CDH and chronic neck pain. STUDY DESIGN: This is a cross-sectional, single-center study...
January 2018: Pain Physician
https://www.readbyqxmd.com/read/29357333/implication-of-two-different-doses-of-intradiscal-ozone-oxygen-injection-upon-the-pain-alleviation-in-patients-with-low-back-pain-a-randomized-single-blind-study
#17
Abdelraheem Elawamy, Emad Zarief Kamel, Manal Hassanien, Ola M Wahba, Shereen Ezzat Amin
BACKGROUND: Low back pain (LBP) is mostly induced by disc herniation (DH) or degeneration and has a burden upon social activity and economical aspects of life. An abundance of medical and surgical interventions have evolved to resolve this problem, but one of the newly introduced techniques, which is the minimally invasive, low cost ozone-oxygen mixture (O₃-O₂) intradiscal injection, offers a rapid onset amelioration of symptoms with a sustained duration of pain relief. OBJECTIVE: We aim to evaluate the quality of pain alleviation using 2 different doses of intradiscal injections of O₃-O₂ mixture...
January 2018: Pain Physician
https://www.readbyqxmd.com/read/29343508/circular-rna-vma21-protects-against-intervertebral-disc-degeneration-through-targeting-mir-200c-and-x-linked-inhibitor-of-apoptosis-protein
#18
Xiaofei Cheng, Liang Zhang, Kai Zhang, Guoying Zhang, Ying Hu, Xiaojiang Sun, Changqing Zhao, Hua Li, Yan Michael Li, Jie Zhao
OBJECTIVES: Circular RNAs (circRNAs) have been proven to function as competing endogenous RNAs to interact with microRNAs (miRNAs) and influence the expression of miRNA target mRNAs. In this study, we investigated whether circRNAs could act as competing endogenous RNAs to regulate the pathological process of intervertebral disc degeneration (IVDD). METHODS: The role and mechanism of a circRNA, circVMA21, in IVDD were explored in nucleus pulposus (NP) cells and degenerative NP tissues from patients and rat models...
January 17, 2018: Annals of the Rheumatic Diseases
https://www.readbyqxmd.com/read/29320615/an-intervertebral-disc-whole-organ-culture-system-to-investigate-proinflammatory-and-degenerative-disc-disease-condition
#19
Gernot Lang, Yishan Liu, Janna Geries, Zhiyu Zhou, David Kubosch, Norbert Südkamp, R Geoff Richards, Mauro Alini, Sibylle Grad, Zhen Li
The aim of this study was to compare the effect of different disease initiators of degenerative disc disease (DDD) within an intervertebral disc (IVD) organ culture system and to understand the interplay between inflammation and degeneration in the early stage of DDD. Bovine caudal IVDs were cultured within a bioreactor for up to 11 days. Control group was cultured under physiological loading (0.02-0.2 MPa; 0.2 Hz; 2 hr/day) and high glucose (4.5 g/L) medium. Detrimental loading (0.32-0.5 MPa, 5 Hz; 2 hr/day) and low glucose (2 g/L) medium were applied to mimic the condition of abnormal mechanical stress and limited nutrition supply...
January 10, 2018: Journal of Tissue Engineering and Regenerative Medicine
https://www.readbyqxmd.com/read/29310946/validation-of-lumbar-spine-loading-from-a-musculoskeletal-model-including-the-lower-limbs-and-lumbar-spine
#20
Jason A Actis, Jasmin D Honegger, Deanna H Gates, Anthony J Petrella, Luis A Nolasco, Anne K Silverman
Low back mechanics are important to quantify to study injury, pain and disability. As in vivo forces are difficult to measure directly, modeling approaches are commonly used to estimate these forces. Validation of model estimates is critical to gain confidence in modeling results across populations of interest, such as people with lower-limb amputation. Motion capture, ground reaction force and electromyographic data were collected from ten participants without an amputation (five male/five female) and five participants with a unilateral transtibial amputation (four male/one female) during trunk-pelvis range of motion trials in flexion/extension, lateral bending and axial rotation...
February 8, 2018: Journal of Biomechanics
keyword
keyword
92965
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"