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https://www.readbyqxmd.com/read/28719931/management-of-a-rare-cause-of-significant-acute-upper-gastrointestinal-bleeding-gastric-lipoma-resected-by-hybrid-endoscopic-submucosal-dissection
#1
Nikolaos Koukias, Alberto Murino, Andrea Telese, Laura Gaeta, Niall Power, Michael Rathbone, Edward J Despott
No abstract text is available yet for this article.
July 18, 2017: Endoscopy
https://www.readbyqxmd.com/read/28718261/modern-management-of-duodenal-variceal-bleeding
#2
Amer Rehman Farooqi, Lawrence Sunderraj
Duodenal variceal bleeding is an uncommon cause of gastrointestinal bleeding. Treatment strategies are reliant on case reports and case series with new developments in interventional treatment modalities including endoscopic therapy, radiological intervention, and surgery. Endoscopic treatment includes injection sclerotherapy using various agents, banding of varices and clipping of varices. Interventional radiological procedures include Transjugular Intrahepatic porto-systemic shunt (TIPSS), and Balloon- Occluded Retrograde Transvenous Obliteration (BRTO)...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28718250/qing-qi-rickshaw-a-boon-or-bane-for-public-transportation-a-study-of-road-traffic-injury-patterns-involving-qing-qi-rickshaws-in-karachi-pakistan
#3
Muhammad Muzzammil, Muhammad Saeed Minhas, Jahanzeb Effendi, Syed Jahanzeb, Ayesha Mughal, Abdul Qadir
BACKGROUND: The three-wheeler Qing-qi and Compressed Natural Gas (CNG) auto-rickshaws were introduced in Karachi to meet the transportation demand of the growing population. These vehicles have directly or indirectly been implicated in a number of road traffic violations as well as road accidents. This study aims to describe the crash characteristics and injury patterns for Qing-qi rickshaw occupants and other road users hit by Qing-qi rickshaw in Karachi, Pakistan. METHODS: An Observational/ Descriptive study was conducted at Accident & Emergency and Orthopaedic Surgery Department, Jinnah Post Graduate Medical Centre, Karachi Pakistan from July 2014 to June 2015...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28718228/early-initiation-of-beta-blockers-following-primary-endoscopic-therapy-for-bleeding-oesophageal-varices-in-cirrhotics
#4
Adnan Salim, Kashif Malik, Muhammad Omer Farooq, Umair Butt, Arshad Kamal Butt, Altaf Alam
BACKGROUND AND AIMS: Beta-blockers provide secondary prophylaxis following endoscopic therapy for variceal bleeding. Guidelines recommend starting beta-blockers 6 days after endoscopy to prevent masking hemodynamic signs of re-bleeding. We aimed to see safety of earlier initiation of betablockers. METHODS: Cirrhotic patients with upper GI bleed were given intravenous vasoactive agents until undergoing endoscopy. Patients with only oesophageal varices as source of bleed were recruited...
April 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28717373/diagnostic-value-of-alarm-symptoms-for-upper-gi-malignancy-in-patients-referred-to-gi-clinic-a-7-years-cross-sectional-study
#5
Mohammad Hasan Emami, Masoud Ataie-Khorasgani, Nasim Jafari-Pozve
BACKGROUND: Early upper gastrointestinal (UGI) cancer detection had led to organ-preserving endoscopic therapy. Endoscopy is a suitable method of early diagnosis of UGI malignancies. In Iran, exclusion of malignancy is the most important indication for endoscopy. This study is designed to see whether using alarm symptoms can predict the risk of cancer in patients. MATERIALS AND METHODS: A total of 3414 patients referred to a tertiary gastrointestinal (GI) clinic in Isfahan, Iran, from 2009 to 2016 with dyspepsia, gastroesophageal reflux disease (GERD), and alarm symptoms, such as weight loss, dysphagia, GI bleeding, vomiting, positive familial history for cancer, and anorexia...
2017: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/28714426/suicide-following-acute-admissions-for-physical-illnesses-across-england-and-wales
#6
S E Roberts, A John, U Kandalama, J G Williams, R A Lyons, K Lloyd
BACKGROUND: The study aim was to establish and quantify suicide risk following acute admissions for all major physical illnesses, for confirmatory purposes, from two independent information sources from different countries. METHODS: Record linkage of inpatient and death certificate data for 11 004 389 acute admissions for physical illnesses in England and 713 496 in Wales. The main outcome measure was standardised mortality ratios (SMRs) for suicide at 1 year following discharge from hospital...
July 17, 2017: Psychological Medicine
https://www.readbyqxmd.com/read/28714029/involvement-of-gut-microbiota-in-the-association-between-gastrointestinal-motility-and-5%C3%A2-ht-expression-m2-macrophage-abundance-in-the-gastrointestinal-tract
#7
Mo Yang, Hirokazu Fukui, Hirotsugu Eda, Yoshitaka Kitayama, Ken Hara, Mio Kodani, Toshihiko Tomita, Tadayuki Oshima, Jiro Watari, Hiroto Miwa
Serotonin (5‑hydroxytryptamine; 5‑HT) may be a key player in gastrointestinal (GI) motility and the GI immune system. In the present study, the effect of gut microbiota on the association between GI motility, and 5‑HT expression and macrophage abundance in the GI tract was examined. Germ‑free (GF) mice (6 weeks old) were orally administered a fecal bacterial suspension prepared from specific pathogen‑free mice and their GI tissues were evaluated 4 weeks later. The expression of 5‑HT and mannose receptor (MR) was examined by immunohistochemistry, and GI transit time (GITT) was measured by administration of carmine red solution...
July 12, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28710883/an-atypical-type-i-gastric-neuroendocrine-tumor
#8
Andrada-Viorela Gheorghe, Mihai Rimbas, Octav Ginghina, Andrada Spanu, Theodor Alexandru Voiosu
BACKGROUND: Gastric neuroendocrine tumors(GI-NETs) are rare lesions, usually discovered incidentally during endoscopy. Based on their pathology, there are 4 types of GI-NETs. Type I are multiple small polypoid lesions with central ulceration located in the gastric body or the fundus, associated with atrophic gastritis usually noninvasive and very rarely metastatic. We report on a rare case of a gastric NET arising from the muscularis propria layer of the pyloric ring. CASE REPORT: We present the case of a 65-year old woman with a history of alcoholic cirrhosis, investigated for melena...
July 14, 2017: Romanian Journal of Internal Medicine, Revue Roumaine de Médecine Interne
https://www.readbyqxmd.com/read/28710747/phase-i-study-of-chimeric-antigen-receptor-modified-t-cells-in-treating-her2-positive-advanced-biliary-tract-cancers-and-pancreatic-cancers
#9
Kaichao Feng, Yang Liu, Yelei Guo, Jingdan Qiu, Zhiqiang Wu, Hanren Dai, Qingming Yang, Yao Wang, Weidong Han
This phase I clinical trial (NCT01935843) is to evaluate the safety, feasibility, and activity of chimeric antigen receptor-engineered T cell (CART) immunotherapy targeting human epidermal growth factor receptor 2 (HER2) in patients with advanced biliary tract cancers (BTCs) and pancreatic cancers (PCs). Eligible patients with HER2-positive (>50%) BTCs and PCs were enrolled in the trial. Well cultured CART-HER2 cells were infused following the conditioning treatment composed of nab-paclitaxel (100-200 mg/m(2)) and cyclophosphamide (15-35 mg/kg)...
July 14, 2017: Protein & Cell
https://www.readbyqxmd.com/read/28710233/venobiliary-fistula-with-haemobilia-a-rare-complication-of-percutaneous-liver-biopsy
#10
Rotimi Ayoola, Parth Jamindar, Renee Williams
We describe a case of a 36-year-old man with a history of chronic hepatitis C who presented with abdominal pain 3 days after undergoing a percutaneous ultrasound-guided liver biopsy. Initial investigations revealed a venobiliary fistula with haemobilia and obstructive jaundice with direct bilirubin peaking at 9.2 mg/dL. He underwent an endoscopic retrograde cholangiopancreatography with sphincterotomy and stent placement, bilirubin decreased to 3.7 mg/dL, and the patient was discharged. The patient returned with recurrent abdominal pain and upper gastrointestinal bleeding with haemoglobin of 8...
July 14, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28709051/collision-tumor-of-choriocarcinoma-and-small-cell-carcinoma-of-the-stomach-a-case-report
#11
Shuichi Fukuda, Yoshinori Fujiwara, Tomoko Wakasa, Keisuke Inoue, Kotaro Kitani, Hajime Ishikawa, Masanori Tsujie, Masao Yukawa, Yoshio Ohta, Masatoshi Inoue
INTRODUCTION: Both gastric choriocarcinoma and small cell carcinoma are extremely rare, both accounting for approximately 0.1% of all gastric cancers. Therefore, simultaneous occurrence of gastric choriocarcinoma and small cell carcinoma is even rarer. PRESENTATION OF CASE: An 84-year-old Japanese man was referred to our hospital with the chief complaint of dysphagia. Laboratory data showed iron deficiency anemia. Contrast-enhanced computed tomography of the abdomen revealed thickened wall of the stomach at the fundus and several enlarged abdominal lymph nodes...
July 8, 2017: International Journal of Surgery Case Reports
https://www.readbyqxmd.com/read/28708568/reference-values-of-fecal-calgranulin-c-s100a12-in-school-aged-children-and-adolescents
#12
Anke Heida, Anneke C Muller Kobold, Lucie Wagenmakers, Koos van de Belt, Patrick F van Rheenen
BACKGROUND: Calgranulin C (S100A12) is an emerging marker of inflammation. It is exclusively released by activated neutrophils which makes this marker potentially more specific for inflammatory bowel disease (IBD) compared to established stool markers including calprotectin and lactoferrin. We aimed to establish a reference value for S100A12 in healthy children and investigated whether S100A12 levels can discriminate children with IBD from healthy controls. METHODS: In a prospective community-based reference interval study we collected 122 stool samples from healthy children aged 5-19 years...
July 14, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28708248/oral-and-upper-gastrointestinal-crohn-s-disease
#13
REVIEW
Robyn Laube, Ken Liu, Mark Schifter, Jessica L Yang, Michael K Suen, Rupert W Leong
Crohn's disease is a heterogeneous, inflammatory condition that can affect any location of the gastrointestinal tract. Proximal gastrointestinal involvement occurs in 0.5-16% of patients, and it is usually diagnosed after recognition of intestinal disease. Symptoms are often mild and non-specific, however upper gastrointestinal disease predicts a more severe Crohn's phenotype with a greater frequency of complications such as obstruction and perforation. Gastroscopy and biopsy is the most sensitive diagnostic investigation...
July 14, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/28707337/systematic-review-with-meta-analysis-the-efficacy-of-faecal-microbiota-transplantation-for-the-treatment-of-recurrent-and-refractory-clostridium-difficile-infection
#14
REVIEW
M N Quraishi, M Widlak, N Bhala, D Moore, M Price, N Sharma, T H Iqbal
BACKGROUND: Clostridium difficile infection (CDI) is the commonest nosocomial cause of diarrhoea. Faecal microbiota transplantation (FMT) is an approved treatment for recurrent or refractory CDI but there is uncertainty about its use. AIM: To evaluate the efficacy of FMT in treating recurrent and refractory CDI and investigate outcomes from modes of delivery and preparation. METHODS: A systematic review and meta-analysis was performed. MEDLINE, EMBASE, CINAHL, Cochrane Library, trial registers and conference proceedings were searched...
July 14, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28706745/acute-esophageal-necrosis-in-an-alcoholic-after-successful-resuscitation-from-cardiac-arrest
#15
Amish Shah, Viveksandeep Thoguluva Chandreskar, Ravi Doobay, Arundeep Kahlon, Ioana Amzuta
INTRODUCTION: We present a patient who presented to the ICU after successful resuscitation from cardiac arrest who was subsequently diagnosed with AEN. CASE PRESENTATION: A 66-year-old female presented after cardiac arrest in which return of spontaneous circulation was achieved within 7 minutes after the initiation of CPR. She was intubated on the scene and found to have coffee ground emesis in her bathroom when found unresponsive. Due to the hemodynamically significant GI bleed, patient was started on IV proton pump inhibitor, octreotide, and levophed...
2017: Case Reports in Gastrointestinal Medicine
https://www.readbyqxmd.com/read/28706428/appropriateness-of-the-study-of-iron-deficiency-anemia-prior-to-referral-for-small-bowel-evaluation-at-a-tertiary-center
#16
Jaime Pereira Rodrigues, Rolando Pinho, Joana Silva, Ana Ponte, Mafalda Sousa, João Carlos Silva, João Carvalho
AIM: To evaluate the adequacy of the study of iron deficiency anemia (IDA) in real life practice prior to referral to a gastroenterology department for small bowel evaluation. METHODS: All consecutive patients referred to a gastroenterology department for small bowel investigation due to iron deficiency anemia, between January 2013 and December 2015 were included. Both patients referred from general practitioners or directly from different hospital departments were selected...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28706425/procalcitionin-as-a-diagnostic-marker-to-distinguish-upper-and-lower-gastrointestinal-perforation
#17
Yang Gao, Kai-Jiang Yu, Kai Kang, Hai-Tao Liu, Xing Zhang, Rui Huang, Jing-Dong Qu, Si-Cong Wang, Rui-Jin Liu, Yan-Song Liu, Hong-Liang Wang
AIM: To assess the accuracy of serum procalcitionin (PCT) as a diagnostic marker in verifying upper and lower gastrointestinal perforation (GIP). METHODS: This retrospective study included 46 patients from the surgical intensive care unit (ICU) of the Second Affiliated Hospital of Harbin Medical University who were confirmed to have GIP between June 2013 and December 2016. Demographic and clinical patient data were recorded on admission to ICU. Patients were divided into upper (n = 19) and lower (n = 27) GIP groups according to the perforation site (above or below Treitz ligament)...
June 28, 2017: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28705805/validation-and-characterization-of-a-novel-method-for-selective-vagal-deafferentation-of-the-gut
#18
Charlene Diepenbroek, Danielle Quinn, Ricky Stephens, Benjamin Zollinger, Seth Anderson, Annabelle Pan, Guillaume de Lartigue
There is a lack of tools that selectively target vagal afferent neurons (VAN) innervating the gut. We use saporin (SAP), a potent neurotoxin, conjugated to the GI hormone cholecystokinin (CCK-SAP) injected into the nodose ganglia (NG) of male Wistar rats to specifically ablate GI-VAN. We report that CCK-SAP ablates a sub-population of VAN in culture. In vivo, CCK-SAP injection into the NG reduces VAN innervating the mucosal and muscular layers of the stomach and small intestine, but not the colon, while leaving vagal efferent neurons intact...
July 13, 2017: American Journal of Physiology. Gastrointestinal and Liver Physiology
https://www.readbyqxmd.com/read/28704230/effect-of-esophageal-cancer-surgeon-volume-on-management-and-mortality-from-emergency-upper-gastrointestinal-conditions-population-based-cohort-study
#19
Sheraz R Markar, Hugh Mackenzie, Alan Askari, Omar Faiz, George B Hanna
OBJECTIVE: To study the influence of esophageal cancer surgeon volume upon mortality from upper gastrointestinal emergencies. BACKGROUND: Volume-outcome relationships led to the centralization of esophageal cancer surgery. METHODS: Hospital Episode Statistics data were used to identify patients admitted to hospitals within England (1997-2012). The influence of esophageal high-volume (HV) cancer surgeon status (≥5 resections per year) upon 30-day and 90-day mortality from esophageal perforation (EP), paraesophageal hernia causing obstruction or gangrene (PEH) and perforated peptic ulcer (PPU) was analyzed, independent of HV esophageal cancer center status and patient and disease-specific confounding factors...
July 12, 2017: Annals of Surgery
https://www.readbyqxmd.com/read/28704090/cortrak-tube-placement-part-1-confirming-by-quadrant-may-be-unsafe
#20
Stephen J Taylor, Rowan Clemente, Kaylee Allan, Sophie Brazier
Gastric confirmation by pH is only achievable in approximately 50% of placements and X-rays are expensive and may be misinterpreted. Bedside electromagnetic (EM) guidance offers real-time confirmation. The authors determined the accuracy of guidance in predicting gastric body position from the EM trace using official Cortrak guidance (the EM trace reaches the bottom left quadrant of the anterior screen) compared with local guidance (detailed anterior-depth description of the GI flexures). X-ray, pH or an EM trace beyond the gastric body were used to independently confirm gastric position...
July 13, 2017: British Journal of Nursing: BJN
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