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https://www.readbyqxmd.com/read/27904562/hyperhomocysteinemia-low-vitamin-b12-and-low-folic-acid-are-risk-factors-of-cerebral-vascular-thrombosis-in-northwest-iran
#1
Ali Akbar Taheraghdam, Nooriyeh Dalirakbari, Mohammad Khalili, Madjid Soltani, Saeid Sadeghieh Ahari
BACKGROUND: Cerebral vascular thrombosis (CVT) is the thrombosis of intracranial and sinuses. The aim of this is to estimate of risk of low folic acid, low vitamin B12, and hyperhomocysteinemia (hyper-Hcys) for CVT. MATERIALS AND METHODS: A total of 24 patients with CVT and 36 healthy controls participated in a cross-sectional case-control study. The deficient levels of folic acid and vitamin B12 defined as <10(th) percentile of folic acid and vitamin B12 level and hyper-Hcys was defined as >90(th) percentile of homocysteine of control group...
2016: Journal of Research in Medical Sciences: the Official Journal of Isfahan University of Medical Sciences
https://www.readbyqxmd.com/read/27883261/prevention-of-neural-tube-defects-in-lrp-mutant-mouse-embryos-by-folic-acid-supplementation
#2
Julia A Sabatino, Bethany A Stokes, Irene E Zohn
BACKGROUND: Neural tube defects (NTDs) are among the most common structural birth defects in humans and are caused by the complex interaction of genetic and environmental factors. Periconceptional supplementation with folic acid can prevent NTDs in both mouse models and human populations. A better understanding of how genes and environmental factors interact is critical toward development of rational strategies to prevent NTDs. Low density lipoprotein-related protein 2 (Lrp2) is involved in endocytosis of the folic acid receptor among numerous other nutrients and ligands...
November 24, 2016: Birth Defects Research. Part A, Clinical and Molecular Teratology
https://www.readbyqxmd.com/read/27876876/fabrication-of-functional-hollow-microspheres-constructed-from-mof-shells-promising-drug-delivery-systems-with-high-loading-capacity-and-targeted-transport
#3
Xuechuan Gao, Xiao Hai, Huricha Baigude, Weihua Guan, Zhiliang Liu
An advanced multifunctional, hollow metal-organic framework (MOF) drug delivery system with a high drug loading level and targeted delivery was designed and fabricated for the first time and applied to inhibit tumour cell growth. This hollow MOF targeting drug delivery system was prepared via a simple post-synthetic surface modification procedure, starting from hollow ZIF-8 successfully obtained for the first time via a mild phase transformation under solvothermal conditions. As a result, the hollow ZIF-8 exhibits a higher loading capacity for the model anticancer drug 5-fluorouracil (5-FU)...
November 23, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27872568/weekly-iron-folic-acid-supplementation-plays-differential-role-in-maintaining-iron-markers-level-in-non-anaemic-and-anaemic-primigravida-a-randomized-controlled-study
#4
Hari Shankar, Neeta Kumar, Rajat Sandhir, Suneeta Mittal, Santosh Kurra, Lakhbir Dhaliwal, Gurjit Kaur, Nomita Chandhiok, B S Dhillon, D N Rao
: Anaemia during pregnancy is most commonly observed and highly prevalent in South-East Asia. Various effective programmes have been laid down for its management, mainly daily supplementation of iron folic acid (IFA) tablets. Following the same, standard obstetrical practice has included the IFA supplementation without requiring the determination of iron deficiency. In this study, a total of 120 primigravida (N = 60; non-anaemic (Hb > 11 g/dl) and N = 60 anaemic (Hb = 8-11 g/dl)) were selected among those attending the Antenatal Clinic in Department of Obstetrics and Gynaecology, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, India...
November 2016: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/27867887/cross-sectional-study-of-nutritional-markers-in-pregnancy
#5
Subhadra Sharma, Jai Bhagwan Sharma, Manisha Yadav, B R Usha, Sunesh Kumar, A K Mukhopadhyay
OBJECTIVES: To note the value of serum Vitamin B12, folic acid, and ferritin in normal and high-risk pregnancies (HRPs) in patients attending antenatal clinic at All India Institute of Medical Sciences (AIIMS). MATERIALS AND METHODS: This is a cross-sectional study where a total of 282 patients attending Gynaecology Outpatient Department at AIIMS, New Delhi, India were recruited. Among the 282 subjects, 251 were pregnant, and 31 were controls. The serum was tested for serum Vitamin B12, serum folic acid, and serum ferritin levels using Beckman Coulter Access 2 immunoassay...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27858927/is-folic-acid-supplementation-useful-for-chronic-kidney-disease
#6
Gonzalo A Bravo-Soto, Trinidad Madrid
Patients with chronic kidney disease have higher cardiovascular risk than general population, a fact that has been linked to high homocysteine levels. Folic acid supplementation can reduce homocysteine levels, which would reduce cardiovascular events. However, there is controversy about the clinical effects of this measure. Searching in Epistemonikos database, which is maintained by screening 30 databases, we identified six systematic reviews comprising 13 trials addressing the question of this article. We combined the evidence using meta-analysis and generated a summary of findings following the GRADE approach...
November 7, 2016: Medwave
https://www.readbyqxmd.com/read/27825815/anemia-and-hematinic-deficiencies-in-anti-gastric-parietal-cell-antibody-positive-or-all-autoantibodies-negative-recurrent-aphthous-stomatitis-patients
#7
Hung-Pin Lin, Yu-Hsueh Wu, Yi-Ping Wang, Yang-Che Wu, Julia Yu-Fong Chang, Andy Sun
BACKGROUND/PURPOSE: Approximately 13% of recurrent aphthous stomatitis (RAS) patients have serum anti-gastric parietal cell antibody (GPCA) positivity. This study assessed whether serum GPCA or RAS itself was a significant factor causing hematinic deficiencies and anemia statuses in GPCA-positive RAS (GPCA+/RAS) and all autoantibodies-negative RAS (Abs-/RAS) patients. METHODS: The mean corpuscular volume (MCV) and mean blood hemoglobin (Hb), iron, vitamin B12, and folic acid levels were measured and compared between any two of three groups of 31 GPCA+/RAS patients, 240 Abs-/RAS patients, and 342 healthy control subjects...
November 5, 2016: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/27799239/effectiveness-of-complementary-food-supplements-and-dietary-counselling-on-anaemia-and-stunting-in-children-aged-6-23-months-in-poor-areas-of-qinghai-province-china-a-controlled-interventional-study
#8
Yanfeng Zhang, Qiong Wu, Wei Wang, Michelle Helena van Velthoven, Suying Chang, Huijun Han, Min Xing, Li Chen, Robert W Scherpbier
OBJECTIVE: To assess the effectiveness of dietary counselling and complementary food supplements on anaemia and stunting prevalence in children aged 6-23 months. DESIGN: A controlled intervention study with measurements of height and haemoglobin levels, and cross-sectional surveys in August 2012 (baseline), 2013 (mid-term) and 2014 (end-line). SETTING: One intervention county and one control county in rural Qinghai Province, China. INTERVENTION: Complementary food supplements (containing protein, fat, carbohydrate, vitamin A, B1, B2, B12, D3, folic acid, iron, zinc and calcium) and complementary feeding counselling were given in the intervention county...
October 31, 2016: BMJ Open
https://www.readbyqxmd.com/read/27790466/maternal-health-situation-in-bihar-and-madhya-pradesh-a-comparative-analysis-of-state-fact-sheets-of-national-family-health-survey-nfhs-3-and-4
#9
REVIEW
Ranjit Kumar Dehury, Janmejaya Samal
INTRODUCTION: Maternal health constitutes the health of women during pregnancy, childbirth and the postpartum period. Bihar and Madhya Pradesh (MP) constitute the Empowered Action Group (EAG) states under National Rural Health Mission (NRHM) and are consistently having poor maternal health indicators. AIM: The main objective of this study was to assess the maternal health situation of Bihar and MP based on National Family Health Survey (NFHS-3) and 4 fact sheets...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/27781559/folic-acid-decorated-polyamidoamine-dendrimer-mediates-selective-uptake-and-high-expression-of-genes-in-head-and-neck-cancer-cells
#10
Leyuan Xu, Shannon Kittrell, W Andrew Yeudall, Hu Yang
AIM: Folic acid (FA)-decorated polyamidoamine dendrimer G4 (G4-FA) was synthesized and studied for targeted delivery of genes to head and neck cancer cells expressing high levels of folate receptors (FRs). METHODS: Cellular uptake, targeting specificity, cytocompatibility and transfection efficiency were evaluated. RESULTS: G4-FA competes with free FA for the same binding site. G4-FA facilitates the cellular uptake of DNA plasmids in a FR-dependent manner and selectively delivers plasmids to FR-high cells, leading to enhanced gene expression...
November 2016: Nanomedicine
https://www.readbyqxmd.com/read/27780269/comparative-assessment-of-vitamin-b12-folic-acid-and-homocysteine-levels-in-relation-to-p53-expression-in-megaloblastic-anemia
#11
Manish K Yadav, Nandini M Manoli, SubbaRao V Madhunapantula
BACKGROUND: Megaloblastic anemia (MBA), also known as macrocytic anemia, is a type of anemia characterized by decreased number of RBCs as well as the presence of unusually large, abnormal and poorly developed erythrocytes (megaloblasts), which fail to enter blood circulation due to their larger size. Lack of vitamin-B12 (VB12) and / or folate (Vitamin-B9, VB9) with elevated homocysteine is the key factor responsible for megaloblastic anemia. Prior studies have demonstrated the induction of apoptosis in these abnormal under-developed erythrocytes...
2016: PloS One
https://www.readbyqxmd.com/read/27765800/sex-specific-associations-between-one-carbon-metabolism-indices-and-posttranslational-histone-modifications-in-arsenic-exposed-bangladeshi-adults
#12
Caitlin G Howe, Xinhua Liu, Megan N Hall, Vesna Ilievski, Marie A Caudill, Olga Malysheva, Angela M Lomax-Luu, Faruque Parvez, Abu B Siddique, Hasan Shahriar, Mohammad N Uddin, Tariqul Islam, Joseph H Graziano, Max Costa, Mary V Gamble
BACKGROUND: Posttranslational histone modifications (PTHMs) are altered by arsenic, an environmental carcinogen. PTHMs are also influenced by nutritional methyl donors involved in one-carbon metabolism (OCM), which may protect against epigenetic dysregulation. METHODS: We measured global levels of three PTHMs, which are dysregulated in cancers (H3K36me2, H3K36me3, H3K79me2), in peripheral blood mononuclear cells (PBMCs) from 324 participants enrolled in the Folic Acid and Creatine Trial, a randomized trial in arsenic-exposed Bangladeshi adults...
October 20, 2016: Cancer Epidemiology, Biomarkers & Prevention
https://www.readbyqxmd.com/read/27739310/-glycine-n-methyltransferase-and-malignant-diseases-of-the-prostate
#13
Z Heger, T Eckschlager, M Stiborová, V Adam
BACKGROUND: Prostate cancer (PC) constitutes a heterogeneous group of diseases with high prevalence rates that are still increasing, particularly in western countries. Since 1980, prostate specific antigen (PSA) and other diagnostic approaches have been used for PC screening; however, some of these approaches are often deemed painful and cause invasive damage of tissue. Therefore, molecular approaches to PC diagnosis are attracting increasing attention, potentially providing patients with less stressful situations and providing better diagnoses and even prognostic information...
2016: Klinická Onkologie: Casopis Ceské a Slovenské Onkologické Spolecnosti
https://www.readbyqxmd.com/read/27730072/study-of-vitamin-b12-deficiency-and-peripheral-neuropathy-in-metformin-treated-early-type-2-diabetes-mellitus
#14
Rudra Prasad Roy, Kaushik Ghosh, Manas Ghosh, Amitava Acharyya, Ambarish Bhattacharya, Mrinal Pal, Sisir Chakraborty, Nilanjan Sengupta
BACKGROUND: Long-term therapy with metformin was shown to decrease the Vitamin B12 level and manifested as peripheral neuropathy. AIM: The aim of this study is to define the prevalence of Vitamin B12 deficiency in early Type 2 diabetic patients (duration ≤5 years or drug treatment ≤3 years) and the relationship among metformin exposure and levels of cobalamin (Cbl), folic acid, and homocysteine (Hcy) with severity of peripheral neuropathy. METHODOLOGY: This is a cross-sectional study involving randomly selected ninety patients (male 56, female 34) between age groups of 35 and 70 years, comparing those who had received >6 months of metformin (Group A) (n = 35) with those without metformin (Group B) (n = 35) and patients taking metformin with other oral hypoglycemic agent (Group C) (n = 20)...
September 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27729579/folic-acid-therapy-reduces-the-first-stroke-risk-associated-with-hypercholesterolemia-among-hypertensive-patients
#15
Xianhui Qin, Jianping Li, J David Spence, Yan Zhang, Youbao Li, Xiaobin Wang, Binyan Wang, Ningling Sun, Fang Chen, Jingxuan Guo, Delu Yin, Liming Sun, Genfu Tang, Mingli He, Jia Fu, Yefeng Cai, Xiuli Shi, Ping Ye, Hong Chen, Shuiping Zhao, Mao Chen, Chuanyu Gao, Xiangqing Kong, Fan Fan Hou, Yining Huang, Yong Huo
BACKGROUND AND PURPOSE: We sought to determine whether folic acid supplementation can independently reduce the risk of first stroke associated with elevated total cholesterol levels in a subanalysis using data from the CSPPT (China Stroke Primary Prevention Trial), a double-blind, randomized controlled trial. METHODS: A total of 20 702 hypertensive adults without a history of major cardiovascular disease were randomly assigned to a double-blind daily treatment of an enalapril 10-mg and a folic acid 0...
November 2016: Stroke; a Journal of Cerebral Circulation
https://www.readbyqxmd.com/read/27723981/self-delivery-nanoparticles-of-amphiphilic-methotrexate-gemcitabine-prodrug-for-synergistic-combination-chemotherapy-via-effect-of-deoxyribonucleotide-pools
#16
Yao Wang, Ping Huang, Minxi Hu, Wei Huang, Xinyuan Zhu, Deyue Yan
The distinct and complementary biochemical mechanisms of folic acid analog methotrexate (MTX) and cytidine analog gemcitabine (GEM) make their synergistic combination effectively. Unfortunately, such a combination faces severe pharmacokinetic problems and several transportation barriers. To overcome these problems, a new strategy of amphiphilic small molecule prodrug (ASMP) is developed to improve their synergistic combination effect. The ASMP was prepared by the amidation of the hydrophilic GEM with the hydrophobic MTX at a fixed ratio...
October 10, 2016: Bioconjugate Chemistry
https://www.readbyqxmd.com/read/27721039/-gold-nanoparticles-composite-folic-acid-conjugated-graphene-oxide-nanohybrids-for-targeted-chemo-thermal-cancer-ablation-in-vitro-screening-and-in-vivo-studies
#17
Gaurav Chauhan, Vianni Chopra, Amit Tyagi, Goutam Rath, Rakesh K Sharma, Amit K Goyal
Nano-graphene oxide (GO) nanometal composite (specifically nanogold and nanosilver) have shown to be a promising material for anticancer therapeutics. Owing to their high drug loading capacity, photothermal and synergizing effects, it is very important to exploit them for targeted chemo-thermal cancer therapeutics. In this work, gold nanoparticles (AuNPs) were selected as the composite metal, folic acid (FA) was taken as GO surface functionalization moiety for active tumor targeting of model anticancer drug Doxorubicin (Dox)...
October 6, 2016: European Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/27719680/potential-for-task-sharing-to-lady-health-workers-for-identification-and-emergency-management-of-pre-eclampsia-at-community-level-in-pakistan
#18
Rehana A Salam, Rahat Najam Qureshi, Sana Sheikh, Asif Raza Khowaja, Diane Sawchuck, Marianne Vidler, Peter von Dadelszen, Shujaat Zaidi, Zulfiqar Bhutta
BACKGROUND: An estimated 276 Pakistani women die for every 100,000 live births; with eclampsia accounting for about 10 % of these deaths. Community health workers contribute to the existing health system in Pakistan under the banner of the Lady Health Worker (LHW) Programme and are responsible to provide a comprehensive package of antenatal services. However, there is a need to increase focus on early identification and prompt diagnosis of pre-eclampsia in community settings, since women with mild pre-eclampsia often present without symptoms...
September 30, 2016: Reproductive Health
https://www.readbyqxmd.com/read/27698720/homocysteine-injures-vascular-endothelial-cells-by-inhibiting-mitochondrial-activity
#19
Fengyong Yang, Xiujing Qi, Zheng Gao, Xingju Yang, Xingfeng Zheng, Chonghao Duan, Jian Zheng
The aim of the present study was to investigate the role of homocysteine (Hcy) in the pathogenesis of pulmonary embolism (PE) and the associated molecular mechanisms in human umbilical vein endothelial cells (HUVECs). Hcy contents were detected with high-performance liquid chromatography. Apoptosis was detected by flow cytometry using Annexin-V staining. Cytochrome c oxidase (COX) activity was assessed with an enzyme activity assay, and the expression levels of COX 17 were determined by western blot analysis...
October 2016: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/27694568/effects-of-prenatal-micronutrient-and-early-food-supplementation-on-metabolic-status-of-the-offspring-at-4-5-years-of-age-the-minimat-randomized-trial-in-rural-bangladesh
#20
Eva-Charlotte Ekström, Emma Lindström, Rubhana Raqib, Shams El Arifeen, Samar Basu, Kerstin Brismar, Katarina Selling, Lars-Åke Persson
BACKGROUND: Fetal nutritional insults may alter the later metabolic phenotype. We hypothesized that early timing of prenatal food supplementation and multiple micronutrient supplementation (MMS) would favourably influence childhood metabolic phenotype. METHODS: Pregnant women recruited 1 January to 31 December 2002 in Matlab, Bangladesh, were randomized into supplementation with capsules of either 30 mg of iron and 400 μg of folic acid, 60 mg of iron and 400 μg of folic acid, or MMS containing a daily allowance of 15 micronutrients, and randomized to food supplementation (608 kcal) either with early invitation (9 weeks' gestation) or usual invitation (at 20 weeks)...
September 30, 2016: International Journal of Epidemiology
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