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https://www.readbyqxmd.com/read/29747834/platelet-count-affects-efficacy-of-folic-acid-in-preventing-first-stroke
#1
Xiangyi Kong, Xiao Huang, Min Zhao, Benjamin Xu, Richard Xu, Yun Song, Yaren Yu, Wenbin Yang, Jingping Zhang, Lishun Liu, Yan Zhang, Genfu Tang, Binyan Wang, Fan Fan Hou, Ping Li, Xiaoshu Cheng, Shuiping Zhao, Xiaobin Wang, Xianhui Qin, Jianping Li, Yong Huo
BACKGROUND: The role of platelets and important effect modifiers on the risk of first stroke is unknown. OBJECTIVES: This study examined whether low platelet count (PLT) and elevated total homocysteine (tHcy) levels jointly increase the risk of first stroke, and, if so, whether folic acid treatment is particularly effective in stroke prevention in such a setting. METHODS: A total of 10,789 Chinese hypertensive adults (mean age 59.5 years; 38% male, with no history of stroke and myocardial infarction) were analyzed from the China Stroke Primary Prevention Trial, where participants were randomly assigned to daily treatments of 10 mg enalapril and 0...
May 15, 2018: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/29732722/network-correlation-analysis-revealed-potential-new-mechanisms-for-neural-tube-defects-beyond-folic-acid
#2
Xiaoya Gao, Richard H Finnell, Hongyan Wang, Yufang Zheng
BACKGROUND: Neural tube defects (NTDs) are clinically significant congenital malformations which are known to be folic acid (FA) responsive, such that supplementation significantly reduces the prevalence of NTDs. Nonetheless, some individuals fail to respond to FA supplementation; hence NTDs remain a significant public health concern. The mechanisms that underlie the beneficial effects of FA supplementation remain poorly understood. Mouse models have been used extensively to study the mechanisms driving neural tube closure (NTC)...
May 6, 2018: Birth Defects Research
https://www.readbyqxmd.com/read/29716764/significantly-higher-frequencies-of-hemoglobin-iron-vitamin-b12-and-folic-acid-deficiencies-and-of-hyperhomocysteinemia-in-patients-with-behcet-s-disease
#3
Ying-Shiung Kuo, Julia Yu-Fong Chang, Yi-Ping Wang, Yang-Che Wu, Yu-Hsueh Wu, Andy Sun
BACKGROUND/PURPOSE: Behcet's disease (BD) patients may have one or more hematinic deficiencies. This study evaluated whether there were significantly higher frequencies of hemoglobin, iron, vitamin B12, and folic acid deficiencies and of hyperhomocysteinemia in BD patients. METHODS: The blood hemoglobin, iron, vitamin B12, folic acid, and homocysteine concentrations in 63 BD patients were measured and compared with the corresponding levels in 126 age- and sex-matched healthy control subjects...
April 28, 2018: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/29709887/association-between-serum-folate-levels-and-caffeinated-beverage-consumption-in-pregnant-women-in-chiba-the-japan-environment-and-children-s-study
#4
Masae Otake, Kenichi Sakurai, Masahiro Watanabe, Chisato Mori
BACKGROUND: Several studies have reported the adverse effects of caffeine intake during pregnancy on fetal health. However, the effects of caffeine intake from green and oolong teas has not been investigated, despite the considerable consumption of these teas in Japan and the potential inhibitory effects of catechins-chemicals present at relatively high levels in green and oolong teas-on folic acid absorption. The potential associations of serum folate levels with caffeinated beverage consumption and catechin levels remain largely unstudied...
April 28, 2018: Journal of Epidemiology
https://www.readbyqxmd.com/read/29696360/randomized-phase-2-study-of-gemcitabine-and-cisplatin-with-or-without-vitamin-supplementation-in-patients-with-advanced-esophagogastric-cancer
#5
A A van Zweeden, C J van Groeningen, R J Honeywell, E Giovannetti, R Ruijter, C H Smorenburg, G Giaccone, H M W Verheul, G J Peters, Hans J van der Vliet
PURPOSE: Preclinical research and prior clinical observations demonstrated reduced toxicity and suggested enhanced efficacy of cisplatin due to folic acid and vitamin B12 suppletion. In this randomized phase 2 trial, we evaluated the addition of folic acid and vitamin B12 to first-line palliative cisplatin and gemcitabine in patients with advanced esophagogastric cancer (AEGC). METHODS: Patients with AEGC were randomized to gemcitabine 1250 mg/m2 (i.v. days 1, 8) and cisplatin 80 mg/m2 (i...
April 25, 2018: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/29687201/folate-promotes-s-adenosyl-methionine-reactions-and-the-microbial-methylation-cycle-and-boosts-ruminants-production-and-reproduction
#6
REVIEW
Imtiaz Hussain Raja Abbasi, Farzana Abbasi, Lamei Wang, Mohamed E Abd El Hack, Ayman A Swelum, Ren Hao, Junhu Yao, Yangchun Cao
Folate has gained significant attention due to its vital role in biological methylation and epigenetic machinery. Folate, or vitamin (B9 ), is only produced through a de novo mechanism by plants and micro-organisms in the rumen of mature animals. Although limited research has been conducted on folate in ruminants, it has been noted that ruminal synthesis could not maintain folate levels in high yielding dairy animals. Folate has an essential role in one-carbon metabolism and is a strong antiproliferative agent...
April 23, 2018: AMB Express
https://www.readbyqxmd.com/read/29683544/high-folate-levels-are-not-associated-with-increased-malaria-risk-but-with-reduced-anemia-rates-in-the-context-of-high-dosed-folate-supplements-and-intermittent-preventive-treatment-against-malaria-in-pregnancy-with-sulphadoxine-pirymethamine-in-benin
#7
Violeta Moya-Alvarez, Smaila Ouédraogo, Manfred Accrombessi, Michel Cot
OBJECTIVES: To investigate if high-dosed folate supplements might diminish the efficacy of malaria intermittent preventive treatment in pregnancy (IPTp) with sulfadoxine-pyrimethamine (SP) in a cohort of pregnant women in Benin, where malaria is holoendemic. METHODS: We followed 318 women during the entire pregnancy and analyzed hematological and P.falciparum indicators in the context of an intermittent preventive treatment trial in Benin. During the follow-up women received two-dose IPTp (1500/75 mg of SP per dose) at the maternity clinic, and 600 mg of albendazole, 200 mg ferrous sulfate and 5 mg folic acid per day for home treatment...
April 23, 2018: Tropical Medicine & International Health: TM & IH
https://www.readbyqxmd.com/read/29678549/title-reversal-of-drug-resistance-by-planetary-ball-milled-pbm-nanoparticle-loaded-with-resveratrol-and-docetaxel-in-prostate-cancer
#8
Santosh Kumar Singh, James W Lillard, Rajesh Singh
The folate receptor (FR) is a valued target that is highly expressed in various cancers, which will expedite the development of ligand-receptor binding based cancer therapeutics. In the present investigation, through tissue microarray analysis, we report higher levels of folate receptor expression in prostate cancer (PCa) tissue derived from patients, which were minimal in normal tissue. For folate-receptor based targeted therapy of PCa, we generated novel planetary ball milled (PBM) nanoparticles (NPs) encapsulated with resveratrol (RES), and in combination with docetaxel (DTX) and conjugated with folic acid (FA) on the surface...
April 17, 2018: Cancer Letters
https://www.readbyqxmd.com/read/29672150/folate-nutrition-status-in-mothers-of-the-boston-birth-cohort-sample-of-a-us-urban-low-income-population
#9
Tina L Cheng, Kamila B Mistry, Guoying Wang, Barry Zuckerman, Xiaobin Wang
OBJECTIVES: To examine maternal folic acid supplementation and plasma folate concentrations in the Boston Birth Cohort, a predominantly urban, low-income, minority population in Boston, Massachusetts. METHODS: This report includes 7612 mothers with singleton live births (3829 Black, 2023 Hispanic, 865 White, and 895 others) enrolled in the Boston Birth Cohort at the Boston Medical Center, during 1999 to 2014. Folic acid supplementation during preconception and each trimester was obtained via interview questionnaire...
April 19, 2018: American Journal of Public Health
https://www.readbyqxmd.com/read/29661647/which-ischemic-stroke-subtype-is-associated-with-hyperhomocysteinemia
#10
Levent Gungor, Murat Polat, Mehlika Berra Ozberk, Bahattin Avci, Ummet Abur
BACKGROUND: Stroke is still a major global health problem in both developed and developing countries. Defining stroke subtype and underlying etiologies is a major step to choose the best method for prophylaxis. Homocysteine is an endothelial toxin and elevated levels have been associated with stroke risk. In this study, we hypothesized that serum total homocysteine level may be related with specific atherothrombotic ischemic stroke subtypes and aimed to find if high serum homocysteine levels are correlated with any specific ischemic stroke subtype...
April 13, 2018: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29650002/identifying-bottlenecks-in-the-iron-and-folic-acid-supply-chain-in-bihar-india-a-mixed-methods-study
#11
Amanda S Wendt, Rob Stephenson, Melissa F Young, Pankaj Verma, Sridhar Srikantiah, Amy Webb-Girard, Carol J Hogue, Usha Ramakrishnan, Reynaldo Martorell
BACKGROUND: Maternal anaemia prevalence in Bihar, India remains high despite government mandated iron supplementation targeting pregnant women. Inadequate supply has been identified as a potential barrier to iron and folic acid (IFA) receipt. Our study objective was to examine the government health system's IFA supply and distribution system and identify bottlenecks contributing to insufficient IFA supply. METHODS: Primary data collection was conducted in November 2011 and July 2012 across 8 districts in Bihar, India...
April 12, 2018: BMC Health Services Research
https://www.readbyqxmd.com/read/29644877/protective-effects-of-folic-acid-on-dna-damage-and-dna-methylation-levels-induced-by-n-methyl-n-nitro-n-nitrosoguanidine-in-kazakh-esophageal-epithelial-cells
#12
Y Chen, H Feng, D Chen, K Abuduwaili, X Li, H Zhang
The protective effects of folic acid on DNA damage and DNA methylation induced by N-methyl- N'-nitro- N-nitrosoguanidine (MNNG) in Kazakh esophageal epithelial cells were investigated using a 3 × 3 factorial design trial. The cells were cultured in vitro and exposed to media containing different concentrations of folic acid and MNNG, after which growth indices were detected. DNA damage levels were measured using comet assays, and genome-wide DNA methylation levels (MLs) were measured using high-performance liquid chromatography...
January 1, 2018: Human & Experimental Toxicology
https://www.readbyqxmd.com/read/29571225/folic-acid-delays-development-of-atherosclerosis-in-low-density-lipoprotein-receptor-deficient-mice
#13
Sunlei Pan, Huahua Liu, Feidan Gao, Hangqi Luo, Hui Lin, Liping Meng, Chengjian Jiang, Yan Guo, Jufang Chi, Hangyuan Guo
Many studies support the cardioprotective effects of folic acid (FA). We aimed to evaluate the utility of FA supplementation in preventing the development of atherosclerotic in low-density lipoprotein receptor-deficient (LDLR-/-) mice and to elucidate the molecular processes underlying this effect. LDLR-/- mice were randomly distributed into four groups: control group, HF group, HF + FA group and the HF + RAPA group. vascular smooth muscle cells (VSMCs) were divided into the following four groups: control group, PDGF group, PDGF + FA group and PDGF + FA + RAPA group...
March 23, 2018: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/29558000/hemolytic-uremic-syndrome-with-dual-caution-in-an-infant-cobalamin-c-defect-and-complement-dysregulation-successfully-treated-with-eculizumab
#14
Ulkem Kocoglu Barlas, Hasan Serdar Kıhtır, Nilufer Goknar, Melike Ersoy, Nihal Akcay, Esra Sevketoglu
BACKGROUND: Hemolytic uremic syndrome (HUS) is a clinical syndrome characterized by hemolytic anemia, thrombocytopenia, and acute kidney injury. Atypical hemolytic uremic syndrome (aHUS) is a devastating disease with significant mortality and high risk of progression to end-stage kidney disease. It is mostly caused by dysregulation of the alternative complement pathway. Cobalamin C (Cbl C) defect is a genetic disorder of cobalamin metabolism and is a rare cause of HUS. CASE-DIAGNOSIS/TREATMENT: We present a 6-month-old male infant who was admitted to the pediatric intensive care unit (PICU) due to restlessness, severe hypertension, anemia, respiratory distress, and acute kidney injury...
March 20, 2018: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
https://www.readbyqxmd.com/read/29546732/folate-supplementation-in-people-with-sickle-cell-disease
#15
REVIEW
Ruchita Dixit, Sowmya Nettem, Simerjit S Madan, Htoo Htoo Kyaw Soe, Adinegara Bl Abas, Leah D Vance, Patrick J Stover
BACKGROUND: Sickle cell disease (SCD) is a group of disorders that affects haemoglobin, which causes distorted sickle- or crescent-shaped red blood cells. It is characterized by anaemia, increased susceptibility to infections and episodes of pain. The disease is acquired by inheriting abnormal genes from both parents, the combination giving rise to different forms of the disease. Due to increased erythropoiesis in people with SCD, it is hypothesized that they are at an increased risk for folate deficiency...
March 16, 2018: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29546377/the-long-term-impact-of-folic-acid-in-pregnancy-on-offspring-dna-methylation-follow-up-of-the-aberdeen-folic-acid-supplementation-trial-afast
#16
Rebecca C Richmond, Gemma C Sharp, Georgia Herbert, Charlotte Atkinson, Caroline Taylor, Sohinee Bhattacharya, Doris Campbell, Marion Hall, Nabila Kazmi, Tom Gaunt, Wendy McArdle, Susan Ring, George Davey Smith, Andy Ness, Caroline L Relton
Background: It has been proposed that maternal folic-acid supplement use may alter the DNA-methylation patterns of the offspring during the in-utero period, which could influence development and later-life health outcomes. Evidence from human studies suggests a role for prenatal folate levels in influencing DNA methylation in early life, but this has not been extended to consider persistent effects into adulthood. Methods: To better elucidate the long-term impact of maternal folic acid in pregnancy on DNA methylation in offspring, we carried out an epigenome-wide association study (EWAS) nested within the Aberdeen Folic Acid Supplementation Trial (AFAST-a trial of two different doses: 0...
March 12, 2018: International Journal of Epidemiology
https://www.readbyqxmd.com/read/29509296/vitamin-b-complex-mitigates-cardiac-dysfunction-in-high-methionine-diet-induced-hyperhomocysteinemia
#17
Jovana Jeremic, Tamara Nikolic Turnic, Vladimir Zivkovic, Nevena Jeremic, Isidora Milosavljevic, Ivan Srejovic, Radmila Obrenovic, Snezana Jancic, Milena Rakocevic, Stevan Matic, Dragan Djuric, Vladimir Jakovljevic
This research is designed to test the hypothesis that elevated homocysteine (Hcy) levels in vivo, caused by a deficit in vitamin B complex, promote changes in cardiac function and redox status that lead to heart failure. In order to conduct the study, we used adult male Wistar albino rats (n = 30; 4 weeks old; 100 ± 15 g body weight). Hyperhomocysteinaemia (HHcy) in these animals was achieved by dietary manipulation. For 4 weeks, the animals were fed with a standard rodent chow (control, CF), a diet enriched in methionine with no deficiency in B vitamins (i...
March 6, 2018: Clinical and Experimental Pharmacology & Physiology
https://www.readbyqxmd.com/read/29493902/integrating-nutrition-into-health-systems-at-community-level-impact-evaluation-of-the-community-based-maternal-and-neonatal-health-and-nutrition-projects-in-ethiopia-kenya-and-senegal
#18
Jacqueline K Kung'u, Richard Pendame, Mame Bineta Ndiaye, Mulusew Gerbaba, Sophie Ochola, Adama Faye, Sulochana Basnet, Edward A Frongillo, Sara Wuehler, Luz Maria De-Regil
Maternal undernutrition and mortality remain high in several African countries. Key nutrition and health interventions improve maternal and birth outcomes. Evidence is scarce on how to strengthen health systems to ensure pregnant women and newborns are reached with these interventions. We conducted three quasi-experimental nonrandomized Community Based Maternal and Neonatal Health and Nutrition projects in regions of Ethiopia, Senegal, and Kenya to demonstrate how proven nutrition interventions could be integrated into health programs to improve knowledge and practices during pregnancy, birth, and postpartum...
February 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29493899/ethiopian-women-s-perspectives-on-antenatal-care-and-iron-folic-acid-supplementation-insights-for-translating-global-antenatal-calcium-guidelines-into-practice
#19
Zewdie Birhanu, Gina M Chapleau, Stephanie E Ortolano, Girma Mamo, Stephanie L Martin, Katherine L Dickin
After decades of global response to iron-deficiency anemia, lessons learned from antenatal iron-folic acid (IFA) supplementation can inform new micronutrient supplementation efforts. The World Health Organization recommends calcium supplementation for the prevention of preeclampsia; however, little is documented on how to design programs to integrate calcium into the standard of care. Twenty interviews with pregnant women and 22 interviews with health providers and volunteers in two districts in Ethiopia were conducted to examine how barriers and facilitators to antenatal care, IFA supplementation, and initial reactions to calcium supplements and regimen might influence adherence and inform future programs...
February 2018: Maternal & Child Nutrition
https://www.readbyqxmd.com/read/29481956/synthesis-and-in-vitro-study-of-modified-chitosan-polycaprolactam-nanocomplex-as-delivery-system
#20
Melina Rezvani, Javad Mohammadnejad, Asghar Narmani, Kazem Bidaki
In this work, chitosan/polycaprolactam (PCL-CS) nano-complex was synthesized and their micelles were formed as self-assembled amphiphilic nano-compartments. These micelles were utilize for drug delivery after loading quercetin (QU) as chemotherapeutic agent and delivery potency of this nano-complex was investigated. This nano-complex was also functionalized with folic acid (FA) in order to targeting delivery of nano-carrier to cancer cell lines. This foure dimensional nano-complex was successfully characterized based on UV-vis, FT-IR, DLS, and TGA analytical devices to confirm the synthesis...
July 1, 2018: International Journal of Biological Macromolecules
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