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https://www.readbyqxmd.com/read/28917233/high-prevalence-of-vitamin-b-12-insufficiency-in-patients-with-crohn-s-disease
#1
Misora Ao, Hidemi Tsuji, Kenichiro Shide, Yuki Kosaka, Akari Noda, Nobuya Inagaki, Hiroshi Nakase, Kiyoshi Tanaka
BACKGROUND AND OBJECTIVES: In Crohn's disease (CD), belonging to inflammatory bowel disease, the small intestine is involved in most cases. Most frequently affected is the distal ileum, where vitamin B-12 is specifically absorbed. Therefore, malabsorption of vitamin B-12 is quite likely to occur in patients with CD. In this study, we have studied the vitamin B-12 status in CD patients. METHODS AND STUDY DESIGN: Forty eight patients with CD were evaluated for their food intake, and circulating concentrations of vitamin B-12, folic acid, and homocysteine (Hcy) as a sensitive marker for the insufficiency of these vitamins and a risk factor of atherosclerosis...
2017: Asia Pacific Journal of Clinical Nutrition
https://www.readbyqxmd.com/read/28906345/folic-acid-exerts-antidepressant-effects-by-upregulating-brain-derived-neurotrophic-factor-and-glutamate-receptor-1-expression-in-brain
#2
Liangcai Gao, Xinnan Liu, Li Yu, Junlin Wu, Mingchu Xu, Yusi Liu
Folic acid is a vitamin with a variety of pharmacological effects. The present study aims to explore the beneficial effects of folic acid on chronic unpredictable mild stress (CUMS)-induced depression-like behaviors and its possible mechanisms. The behavioral tests including open-field test, tail suspension test, and forced swimming test were used to evaluate the antidepressant effects of folic acid. Then the changes of brain 5-hydroxytryptamine (5-HT) concentration, brain-derived neurotrophic factor (BDNF), glutamate receptor 1 (GluR1) expression levels, and synaptic organization were assessed to explore the antidepressant mechanisms of folic acid...
September 12, 2017: Neuroreport
https://www.readbyqxmd.com/read/28904497/the-effect-of-metformin-treatment-on-the-serum-levels-of-homocysteine-folic-acid-and-vitamin-b12-in-patients-with-polycystic-ovary-syndrome
#3
Sedigheh Esmaeilzadeh, Maryam Gholinezhad-Chari, Reza Ghadimi
BACKGROUND AND OBJECTIVE: Hyperhomocysteinemia is a well-known risk factor for cardiovascular disease. Although metformin therapy can increase homocysteine (Hcy) levels, it frequently is used as an oral medicine in women with polycystic ovary syndrome (PCOS), who might be at risk of catching diabetes mellitus. The aim of this study was to investigate the effect of metformin on the levels of serum Hcy, vitamin B12 (vit B12), and folic acid in patients with PCOS. MATERIALS AND METHODS: An interventional study was designed with 18 patients with PCOS at the Fatemehzahra infertility Hospital in Babol, Iran...
April 2017: Journal of Human Reproductive Sciences
https://www.readbyqxmd.com/read/28903160/safety-of-systemic-agents-for-the-treatment-of-pediatric-psoriasis
#4
Inge M G J Bronckers, Marieke M B Seyger, Dennis P West, Irene Lara-Corrales, Megha Tollefson, Wynnis L Tom, Marcia Hogeling, Leah Belazarian, Claus Zachariae, Emmanuel Mahé, Elaine Siegfried, Sandra Philipp, Zsuzsanna Szalai, Ruth Ann Vleugels, Kristen Holland, Ruth Murphy, Eulalia Baselga, Kelly Cordoro, Jo Lambert, Alex Alexopoulos, Ulrich Mrowietz, Wietske Kievit, Amy S Paller
Importance: Use of systemic therapies for moderate to severe psoriasis in children is increasing, but comparative data on their use and toxicities are limited. Objective: To assess patterns of use and relative risks of systemic agents for moderate to severe psoriasis in children. Design, Setting, and Participants: A retrospective review was conducted at 20 centers in North America and Europe, and included all consecutive children with moderate to severe psoriasis who used systemic medications or phototherapy for at least 3 months from December 1, 1990, to September 16, 2014...
September 13, 2017: JAMA Dermatology
https://www.readbyqxmd.com/read/28902145/replacing-american-breakfast-foods-with-ready-to-eat-rte-cereals-increases-consumption-of-key-food-groups-and-nutrients-among-us-children-and-adults-results-of-an-nhanes-modeling-study
#5
Colin D Rehm, Adam Drewnowski
Replacing the typical American breakfast with ready-to-eat cereals (RTECs) may improve diet quality. Our goal was to assess the impact of RTECs on diet quality measures for different age groups, using substitution modeling. Dietary intakes came from the 2007-2010 National Health and Examination Surveys (NHANES; n = 18,112). All breakfast foods, excluding beverages, were replaced on a per calorie basis, with frequency-weighted and age/race specific RTECs. Model 1 replaced foods with RTECs alone; Model 2 replaced foods with RTECs and milk...
September 13, 2017: Nutrients
https://www.readbyqxmd.com/read/28895788/association-between-serum-unmetabolized-folic-acid-concentrations-and-folic-acid-from-fortified-foods
#6
Cecília Zanin Palchetti, Clóvis Paniz, Eduardo de Carli, Dirce M Marchioni, Célia Colli, Josiane Steluti, Christine M Pfeiffer, Zia Fazili, Elvira Maria Guerra-Shinohara
OBJECTIVE: To investigate the association between serum unmetabolized folic acid (UMFA) concentrations and folic acid from fortified foods and nutrients known as dietary methyl-group donors (folate, methionine, choline, betaine and vitamins B2, B6 and B12) in participants exposed to mandatory fortification of wheat and maize flours with folic acid. METHODS: Cross-sectional study carried out with 144 healthy Brazilian participants, both sexes, supplement nonusers...
September 12, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28887720/early-folic-acid-supplement-initiation-and-risk-of-adverse-early-childhood-respiratory-health-a-population-based-study
#7
Vivian H Alfonso, Gretchen Bandoli, Ondine von Ehrenstein, Beate Ritz
Objectives Folate plays a vital role in biologic functions yet women often do not meet the recommended dietary intake in pregnancy. It has been suggested that high folic acid intake during pregnancy may increase the risk of respiratory diseases in offspring. However, findings from observational studies in human populations are inconclusive. Methods In this population-based study, we collected self-reported folic acid and prenatal vitamin supplement use during pregnancy 3-6 months postpartum from mothers in Los Angeles whose children were born in 2003...
September 8, 2017: Maternal and Child Health Journal
https://www.readbyqxmd.com/read/28885600/a-cross-sectional-study-of-dietary-and-genetic-predictors-of-blood-folate-levels-in-healthy-young-adults
#8
Daniel Cummings, Kevin F Dowling, Noah J Silverstein, Alexandra S Tanner, Hamdi Eryilmaz, Jordan W Smoller, Joshua L Roffman
Since 1998, the U.S. has mandated folic acid (FA) fortification of certain grain products to reduce the risk of neural tube defects. Folate intake and red blood cell (RBC) folate concentrations increased substantially post-intervention, although recent studies raise concerns about the level of ongoing benefit. This study investigated blood folate level determinants in healthy young adults, including intake of naturally occurring food folate, synthetic FA, and the interaction of naturally occurring food folate with a common missense variant in the FOLH1 gene thought to affect absorption...
September 8, 2017: Nutrients
https://www.readbyqxmd.com/read/28885096/infant-hydrocephalus-in-sub-saharan-africa-the-reality-on-the-tanzanian-side-of-the-lake
#9
Maria M Santos, Derick K Rubagumya, Imani Dominic, Amos Brighton, Soledad Colombe, Philip O'Donnell, Micaella R Zubkov, Roger Härtl
OBJECTIVE Infant hydrocephalus is estimated to affect more than 100,000 new infants each year in sub-Saharan Africa (SSA). Bugando Medical Centre (BMC), a government-funded and patient cost-shared referral center, serves over 13 million people in the Lake and Western regions of Tanzania. The goals of this study were to characterize the infant population affected by hydrocephalus who presented to BMC and were treated with a ventriculoperitoneal shunt (VPS) to determine the rate of early complications associated with this surgical procedure and to assess its potential risk factors...
September 8, 2017: Journal of Neurosurgery. Pediatrics
https://www.readbyqxmd.com/read/28885005/mof-mediated-destruction-of-cancer-using-the-cell-s-own-hydrogen-peroxide
#10
Hadi Ranji-Burachaloo, Fatemeh Karimi, Ke Xie, Qiang Fu, Paul Andrew Gurr, David Edwin Dunstan, Greg G Qiao
A novel reduced iron metal-organic framework nanoparticle with cytotoxicity specific to cancer cells is presented. This nanoparticle was prepared via a hydrothermal method, then reduced using hydroquinone and finally conjugated with folic acid (namely, rMOF-FA). The synthesized nanoparticle shows the controlled release of iron in an acidic ex-vivo environment. Iron present on the rMOF-FA, and released into solution can react with high levels of hydrogen peroxide found specifically in cancer cells to increase the hydroxyl radical concentration...
September 8, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28883079/folate-dietary-insufficiency-and-folic-acid-supplementation-similarly-impair-metabolism-and-compromise-hematopoiesis
#11
Curtis J Henry, Travis Nemkov, Matias Casas-Selves, Ganna Bilousova, Vadym Zaberezhnyy, Kelly C Higa, Natalie J Serkova, Krik C Hansen, Angelo D' Alessandro, James DeGregori
While dietary folate deficiency is associated with increased risk for birth defects and other diseases, evidence suggests that supplementation with folic acid can contribute to predisposition to some diseases, including immune dysfunction and cancer. Here we show that diets supplemented with folic acid both below and above the recommended levels led to significantly altered metabolism in multiple tissues in mice. Surprisingly, both low and excessive dietary folate induced similar metabolic changes, which were particularly evident for nucleotide biosynthetic pathways in B-progenitor cells...
September 7, 2017: Haematologica
https://www.readbyqxmd.com/read/28881206/polyglycerolated-nanocarriers-with-increased-ligand-multivalency-for-enhanced-invivo-therapeutic-efficacy-of-paclitaxel
#12
Trang Huyen Le Kim, Jeong Heon Yu, Hwiseok Jun, Moon Young Yang, Mi-Jin Yang, Jae-Woo Cho, Jin Woong Kim, Jee Seon Kim, Yoon Sung Nam
Despite the excellent biocompatibility and antifouling effect of poly(ethylene glycol) (PEG), the high steric hindrance, limited chemical functionality, and low ligand multivalency of PEGylated nanocarriers often lead to inefficient cell targeting and intracellular trafficking. Hence, a new structure of hydrophilic corona allowing a higher ligand density without loss of excellent biocompatibility is highly desirable. Here we introduce tumor-targeted polyglycerolated (PGylated) nanocarriers that dramatically enhance the in vivo therapeutic efficacy of incorporated paclitaxel simply by increasing the surface density of hydrophobic tumor-targeting ligands...
August 29, 2017: Biomaterials
https://www.readbyqxmd.com/read/28870524/folic-acid-supplement-use-and-the-risk-of-gestational-hypertension-and-preeclampsia
#13
Maria P G De Ocampo, Maria Rosario G Araneta, Caroline A Macera, John E Alcaraz, Thomas R Moore, Christina D Chambers
BACKGROUND: Hypertensive disorders of pregnancy are among the leading causes of maternal morbidity and mortality. Studies suggest that the use of folic acid may lower the risk of hypertensive disorders in pregnant women. AIM: The aim of this study was to assess the effects of timing and duration of folic acid-containing supplement use on the risk for gestational hypertension and preeclampsia. METHODS: Exposures and outcomes data were obtained through interviews and review of participant's medical records from the MotherToBaby cohort studies across the United States and Canada...
September 1, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/28868093/on-the-cellular-and-molecular-mechanisms-of-drug-induced-gingival-overgrowth
#14
Albert Ramírez-Rámiz, Lluís Brunet-LLobet, Eduard Lahor-Soler, Jaume Miranda-Rius
INTRODUCTION: Gingival overgrowth has been linked to multiple factors such as adverse drug effects, inflammation, neoplastic processes, and hereditary gingival fibromatosis. Drug-induced gingival overgrowth is a well-established adverse event. In early stages, this gingival enlargement is usually located in the area of the interdental papilla. Histologically, there is an increase in the different components of the extracellular matrix. OBJECTIVE: The aim of this manuscript is to describe and analyze the different cellular and molecular agents involved in the pathogenesis of Drug-induced gingival overgrowth...
2017: Open Dentistry Journal
https://www.readbyqxmd.com/read/28867793/diet-gut-microbiome-and-epigenetics-emerging-links-with-inflammatory-bowel-diseases-and-prospects-for-management-and-prevention
#15
REVIEW
Krasimira Aleksandrova, Beatriz Romero-Mosquera, Vicent Hernandez
Inflammatory bowel diseases (IBD) represent a growing public health concern due to increasing incidence worldwide. The current notion on the pathogenesis of IBD is that genetically susceptible individuals develop intolerance to dysregulated gut microflora (dysbiosis) and chronic inflammation develops as a result of environmental triggers. Among the environmental factors associated with IBD, diet plays an important role in modulating the gut microbiome, influencing epigenetic changes, and, therefore, could be applied as a therapeutic tool to improve the disease course...
August 30, 2017: Nutrients
https://www.readbyqxmd.com/read/28861004/the-temporal-relationship-between-arterial-stiffening-and-blood-pressure-is-modified-by-methotrexate-treatment-in-patients-with-rheumatoid-arthritis
#16
Richard J Woodman, Leena R Baghdadi, Michael E Shanahan, Arduino A Mangoni
Background: The temporal relationship between arterial stiffness and blood pressure (BP) may vary depending on age and other clinical and demographic factors. Since both BP and arterial stiffness are also affected by inflammatory processes, we examined the temporal arterial stiffness-BP relationship in patients with rheumatoid arthritis (RA) treated with either methotrexate (MTX), an anti-rheumatic agent shown to reduce cardiovascular risk in meta-analyses, or other disease-modifying anti-rheumatic drugs (DMARDs)...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28854002/efficacy-of-folic-acid-therapy-in-patients-with-hyperhomocysteinemia
#17
Huizi Tian, Dandan Tian, Chengda Zhang, Wenhua Wang, Lianke Wang, Mengying Ge, Quanliang Hou, Weidong Zhang
BACKGROUND: Increased plasma homocysteine (Hcy) levels are a risk factor for stroke and can be reduced with folic acid therapy. Therefore, it is extremely important for patients with hyperhomocysteinemia (HHcy) to obtain the normal level of Hcy after folate intervention. Thus far, few studies have reported the effective rate defined as percentage of patients who achieved normal plasma Hcy levels after folic acid therapy. OBJECTIVES: The present study aimed to investigate the effective rate of folic acid for the treatment of HHcy and the impact of plasma baseline Hcy levels and the compliance of oral folic acid on the efficacy...
August 30, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28844212/a-cross-sectional-study-of-complementary-and-alternative-medicine-use-in-patients-with-coagulation-disorders-in-southern-iran
#18
Mohammadreza Bordbar, Mehdi Pasalar, Rezvan Aresehiri, Sezaneh Haghpanah, Soheila Zareifar, Fatemeh Amirmoezi
OBJECTIVE: Complementary and alternative medicine (CAM) use has an increasing trend around the world. Despite the wild application of CAM in patients with coagulation disorders, its efficacy is still questioned by many studies. The aim of this study was to determine the frequency and types of CAM usage, and the factors affecting CAM use among patients with bleeding disorders. METHODS: This cross-sectional study investigated the usage of CAM with a standard validated questionnaire in coagulopathic patients who were referred to Dastgheib Hospital, an educational therapeutic center affiliated to the Shiraz University of Medical Sciences in Shiraz, Southern Iran...
September 2017: Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28835136/chitosan-graft-mpeg-based-5-fluorouracil-loaded-polymeric-nanoparticles-for-tumor-targeted-drug-delivery
#19
M Gover Antoniraj, Mahesh Ayyavu, Linda Jeeva Kumari Henry, Goutham Nageshwar Rao, Subramanian Natesan, D Sathish Sundar, Ruckmani Kandasamy
Biodegradable materials like chitosan (CH) and methoxy polyethylene glycol (mPEG) are widely being used as drug delivery carriers for various therapeutic applications. In the present study, copolymer (CH-g-mPEG) of chitosan and carboxylic acid terminated mPEG was synthesized by carbodiimide mediated acid amine reaction. The resultant hydrophilic copolymer was characterized by FTIR and (1)H NMR studies, revealing its relevant functional bands and proton peaks respectively. Blank polymeric nanoparticles (B-PNPs) and 5-Fluorouracil loaded polymeric nanoparticles (5-FU-PNPs) were formulated by ionic gelation method...
August 24, 2017: Drug Development and Industrial Pharmacy
https://www.readbyqxmd.com/read/28818268/-metformin-resistant-folic-acid-producing-probiotics-or-folic-acid-against-metformin-s-adverse-effects-like-diarrhea
#20
Abdullah Olgun
Metformin, first line medication in the treatment of type2 diabetes by millions of patients worldwide, causes gastrointestinal adverse effects (i.e. diarrhea) in approximately 30% of patients, frequently leading to discontinuation. Interestingly, metformin was reported to increase life span in a microscopic worm, Caenorhabditis elegans, by decreasing folate and methionine production of bacteria that this worm uses as a food source. Metformin can be expected to have a similar effect on some microorganisms of human gut microbiota...
September 2017: Medical Hypotheses
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