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kidney heart vasculitis acute

F Su, Q Qiu, D M Cai, L Q Liang, X Y Yang
OBJECTIVE: To evaluate the clinical features, treatment and prognosis of Eosinophilic Granulomatous Vasculitis. METHODS: We analyzed retrospectively the clinical and laboratory features, treatment and prognosis of 43 patients with Eosinophilic Granulomatous Vasculitis who admitted to the Department of Rheumatology of the First Affiliated University Hospital of Sun Yat-sen University between 2005 and 2014. RESULTS: Of the 43 patients, 31 patients (72...
July 19, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
(no author information available yet)
No abstract text is available yet for this article.
June 2016: Annals of Intensive Care
Verónica Yauri, Yagahira E Castro-Sesquen, Manuela Verastegui, Noelia Angulo, Fernando Recuenco, Ines Cabello, Edith Malaga, Caryn Bern, Cesar M Gavidia, Robert H Gilman
Pigs were infected with a Bolivian strain of Trypanosoma cruzi (genotype I) and evaluated up to 150 days postinoculation (dpi) to determine the use of pigs as an animal model of Chagas disease. Parasitemia was observed in the infected pigs during the acute phase (15-40 dpi). Anti-T. cruzi immunoglobulin M was detected during 15-75 dpi; high levels of anti-T. cruzi immunoglobulin G were detected in all infected pigs from 75 to 150 dpi. Parasitic DNA was observed by western blot (58%, 28/48) and polymerase chain reaction (27%, 13/48) in urine samples, and in the brain (75%, 3/4), spleen (50%, 2/4), and duodenum (25%, 1/4), but no parasitic DNA was found in the heart, colon, and kidney...
May 4, 2016: American Journal of Tropical Medicine and Hygiene
Catherine E Najem, Rajwardhan Yadav, Elise Carlson
Eosinophilic granulomatosis with polyangiitis (EGPA) is a rare eosinophil-rich disorder characterised by necrotising granulomatous inflammation affecting small to medium sized vessels. Extrapulmonary manifestations can be life-threatening when heart, central nervous system (CNS), gastrointestinal tract or kidneys are affected. We describe a case of a 56-year-old woman with a long-standing history of asthma, who presented with an acute sudden painless loss of vision after she had been recently diagnosed with EGPA and induced with pulse steroids and cyclophosphamide...
May 15, 2015: BMJ Case Reports
Olga Balafa, Georgios Liapis, Anila Duni, Sophia Xiromeriti, Rigas Kalaitzidis, Moses Elisaf
We present a case which emphasizes the importance of performing a kidney biopsy in each case of acute kidney injury (AKI) of unknown etiology. The unexpected histological diagnosis of granulomatous interstitial nephritis (GIN) is a rare cause of AKI. The main causes of GIN include drugs (NSAIDs, antibiotics), sarcoidosis, and infections (mycobacterial and fungal). In our case, a 68-year-old woman was admitted with AKI, absence of symptoms and unremarkable history, apart from coronary heart disease. Renal biopsy was performed, since history as well as clinical and laboratory data could not define a cause of AKI...
October 2015: Clinical Nephrology
Rahel S Spindler, Peter Schnuelle, Lukas Nickels, Jonas Jarczyk, Rüdiger Waldherr, Sonja Theisinger, Bastian Theisinger, Sarah Klotz, Charalambos Tsagogiorgas, Uwe Göttmann, Bernhard K Krämer, Benito A Yard, Simone Hoeger
BACKGROUND: This study investigated the potential use of N-octanoyl dopamine (NOD) in donor management to ameliorate the damage caused by brain death and ischemia-reperfusion injury in a rat model of kidney and heart transplantation. METHODS: Brain-dead Fisher rats were treated for 6 hours with either saline or saline plus NOD. Orthotopic kidney and heterotopic heart transplantation were performed in different Lewis recipient rats. The right donor kidneys were stored for biochemical analysis...
May 2015: Transplantation
Jolanta Załęska, Elżbieta Wiatr, Jacek Zych, Janusz Szopiński, Karina Oniszh, Jarosław Kober, Dorota Piotrowska-Kownacka, Kazimierz Roszkowski-Śliż
Patients with cardiovascular symptoms are mainly diagnosed in cardiological wards. However, sometimes the other reasons for acute coronary syndrome and heart failure are found. One of such reasons is hypereosinophilia which can be recognized if number of blood eosinophils exceeds 1500/mm3. High eosinophilia is connected with production of cytotoxic eosinophilic proteins which can cause eosinophilic vasculitis or eosinophilic myocarditis. One of the better known hypereosinophilic syndromes is EGPA described by the pathomorphologists Churg and Strauss...
2014: Pneumonologia i Alergologia Polska
Manish Suneja, Shalanki Baiswar, Scott A Vogelgesang
Hydralazine is a medication that has been used to manage hypertension and heart failure. In this case series, we report 4 patients who presented to a large, Midwestern academic medical center on chronic hydralazine therapy with acute kidney injury, nephritic urine sediment on urine microscopy, and the simultaneous presence of autoantibodies suggesting both drug-induced lupus and drug-induced vasculitis. All of them had evidence of pauci-immune glomerulonephritis on kidney biopsy. All the patients reported in our series are white women older than 60 years who were receiving hydralazine for more than 12 months at a dose of 150 mg or more...
March 2014: Journal of Clinical Rheumatology: Practical Reports on Rheumatic & Musculoskeletal Diseases
José Hernández-Rodríguez, Marco A Alba, Sergio Prieto-González, Maria C Cid
Polyarteritis nodosa (PAN) is a systemic necrotizing vasculitis preferentially targeting medium-sized arteries and not associated with glomerulonephritis or small vessel involvement. Anti-neutrophil cytoplasmic antibodies are typically negative. PAN may be triggered by viral infections, particularly hepatitis B virus, but remains idiopathic in most cases. Clinical manifestations of PAN are multisystemic. Peripheral nerve and skin are the most frequently affected tissues. Involvement of the gastrointestinal tract, kidneys, heart, and central nervous system is associated with higher mortality...
February 2014: Journal of Autoimmunity
Hillary R Mount
A 76-year-old woman with a history of stage IV chronic kidney disease and hypertension was admitted to the hospital for progressive weakness and acute on chronic kidney injury. She was found to have anaemia requiring transfusion. On the evening of admission, she had worsening respiratory status with subsequent diagnosis of a non-ST-elevation myocardial infarction, pulmonary oedema on chest x-ray presumed to be a result of heart failure, and a possible transfusion reaction. A kidney biopsy performed as part of her ongoing nephrology evaluation revealed granulomatosis with polyangiitis (formerly known as Wegener's granulomatosis)...
2013: BMJ Case Reports
Florence Roufosse
No abstract text is available yet for this article.
April 2013: La Presse Médicale
Alexandre Karras, Christian Jacquot, Eric Thervet
No abstract text is available yet for this article.
April 2013: La Presse Médicale
Yolanda Braun-Moscovici, Yonatan Butbul-Aviel, Ludmila Guralnik, Kochava Toledano, Doron Markovits, Alexander Rozin, Menahem A Nahir, Alexandra Balbir-Gurman
Rituximab (RTX) is a chimeric anti-CD20 antibody, approved for rheumatoid arthritis (RA) patients who failed anti-Tumor Necrosis Factor therapy. It has been used occasionally for life-threatening autoimmune diseases (AID). We report our center experience in the use of RTX in life-threatening complications or refractory AID. Clinical charts of patients treated with RTX at our center were reviewed, cases treated for life-threatening complications or refractory AID were analyzed. Acute damage to vital organs such as lung, heart, kidney, nervous system with severe functional impairment were defined as life-threatening complications; treatment failure with high-dose corticosteroids, cyclophosphamide, IVIG, plasmapheresis was defined as refractory autoimmune disease...
June 2013: Rheumatology International
Mohamad Zaidan, Eric Mariotte, Lionel Galicier, Bertrand Arnulf, Véronique Meignin, Jérôme Vérine, Alfred Mahr, Elie Azoulay
Vasculitis is characterized by the infiltration of vessel walls by inflammatory leukocytes with reactive damage and subsequent loss of vessel integrity. The clinical course of systemic vasculitis may be punctuated by acute life-threatening manifestations that require intensive care unit (ICU) admission. Furthermore, the diagnosis may be established in the ICU after admission for a severe inaugural symptom, mostly acute respiratory failure. Among the systemic vasculitides, cryoglobulinemic vasculitis (CV) has been rarely studied in an ICU setting...
2012: Annals of Intensive Care
Chien-Yi Hsu, Wei-Sheng Chen, Shih-Hsien Sung
Warfarin is widely prescribed for patients with atrial fibrillation. In addition to unexpected bleeding, allergic skin reaction is one of its uncommon adverse effects. We herein report an 89-year-old man who, after taking warfarin for 4 years, suffered extensive skin eruptions. The skin biopsy disclosed leukocytoclastic vasculitis. The causal relationship between skin lesions and warfarin was confirmed after re-challenge of warfarin. A literature review revealed only 13 such cases reported from 1980 to 2011...
2012: Internal Medicine
Amin R Soliman
INTRODUCTION: Data concerning the spectrum of acute kidney injury (AKI) in Egypt are scarce. The study aims to describe the spectrum of AKI in a tertiary hospital in Cairo. METHODS: We retrospectively collected the data of all cases of AKI who were treated at Dar El Shefa Hospital, Cairo, Egypt, from January 2006 to January 2007. RESULTS: There were 51 cases of AKI during the study period (29 males and 22 females). Their age ranged from 19 to 81 years with a mean of 48 years...
May 2011: Arab Journal of Nephrology and Transplantation
Belda Dursun, Baki Yagci, Mehmet Batmazoglu, Gokcen Demiray
Fibromuscular dysplasia (FMD) is an uncommon disorder, accounting for less than 10% of cases of renal artery stenosis, and typically presenting with hypertension in young women. This article reports the case of a previously healthy 37-year-old man presenting with acute-onset, severe, bilateral flank pain. Initially treated for ureteral colic and urinary tract infection, he was transferred to the nephrology clinic upon recognition of a rising serum creatinine. He was found to have FMD of bilateral renal arteries with a stenotic pattern on the right side and a dissecting aneurysm on the left side with resultant infarctions in both kidneys...
February 2012: Scandinavian Journal of Urology and Nephrology
Philip S Barie, Soumitra R Eachempati
Acute acalculous cholecystitis (ACC) can develop with or without gallstones after surgery and in critically ill or injured patients. Diabetes mellitus, malignant disease, abdominal vasculitis, congestive heart failure, cholesterol embolization, shock, and cardiac arrest also have been associated with AAC. The pathogenesis of AAC is complex and multifactorial. Ultrasound of the gallbladder is most accurate for the diagnosis of AAC in the critically ill patient. CT is probably of comparable accuracy, but carries both advantages and disadvantages...
June 2010: Gastroenterology Clinics of North America
Michael J Dillon, Despina Eleftheriou, Paul A Brogan
Medium-size-artery vasculitides do occur in childhood and manifest, in the main, as polyarteritis nodosa (PAN), cutaneous PAN and Kawasaki disease. Of these, PAN is the most serious, with high morbidity and not inconsequential mortality rates. New classification criteria for PAN have been validated that will have value in epidemiological studies and clinical trials. Renal involvement is common and recent therapeutic advances may result in improved treatment options. Cutaneous PAN is a milder disease characterised by periodic exacerbations and often associated with streptococcal infection...
September 2010: Pediatric Nephrology: Journal of the International Pediatric Nephrology Association
K T Wong, T Robertson, B B Ong, J W Chong, K C Yaiw, L F Wang, A J Ansford, A Tannenberg
AIM: To study the pathology of two cases of human Hendra virus infection, one with no clinical encephalitis and one with relapsing encephalitis. METHODS: Autopsy tissues were investigated by light microscopy, immunohistochemistry and in situ hybridization. RESULTS: In the patient with acute pulmonary syndrome but not clinical acute encephalitis, vasculitis was found in the brain, lung, heart and kidney. Occasionally, viral antigens were demonstrated in vascular walls but multinucleated endothelial syncytia were absent...
June 2009: Neuropathology and Applied Neurobiology
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