S Banai, Y Wolf, G Golomb, A Pearle, J Waltenberger, I Fishbein, A Schneider, A Gazit, L Perez, R Huber, G Lazarovichi, L Rabinovich, A Levitzki, S D Gertz
BACKGROUND: Signaling through protein tyrosine kinases (PTKs) is a major contributor to the transmission of mitogenic stimuli to the interior of the cell and nucleus. The present study was designed to determine the effect of the tyrphostin AG1295, a selective blocker of PDGF-receptor PTK, on the growth of porcine and human smooth muscle cells (SMCs) in culture, on the outgrowth kinetics of SMCs from porcine and human arterial explants, and on neointimal formation after balloon injury in pigs...
May 19, 1998: Circulation