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https://www.readbyqxmd.com/read/29341542/intrinsic-fluorescence-for-cervical-precancer-detection-using-polarized-light-based-in-house-fabricated-portable-device
#1
Bharat Lal Meena, Pankaj Singh, Amar Nath Sah, Kiran Pandey, Asha Agarwal, Chayanika Pantola, Asima Pradhan
An in-house fabricated portable device has been tested to detect cervical precancer through the intrinsic fluorescence from human cervix of the whole uterus in a clinical setting. A previously validated technique based on simultaneously acquired polarized fluorescence and polarized elastic scattering spectra from a turbid medium is used to extract the intrinsic fluorescence. Using a diode laser at 405 nm, intrinsic fluorescence of flavin adenine dinucleotide, which is the dominant fluorophore and other contributing fluorophores in the epithelium of cervical tissue, has been extracted...
January 2018: Journal of Biomedical Optics
https://www.readbyqxmd.com/read/29333882/vaginoplasty-what-s-new-from-1946-to-date-commentary-on-vaginoplasty-with-acellular-dermal-matrix-after-radical-resection-for-carcinoma-of-the-uterine-cervix
#2
Roberto Cuomo, Luca Grimaldi, Cesare Brandi, Andrea Sisti, Giuseppe Nisi
No abstract text is available yet for this article.
January 15, 2018: Journal of Investigative Surgery: the Official Journal of the Academy of Surgical Research
https://www.readbyqxmd.com/read/29332370/hallmarks-in-the-evolution-of-gynaecological-cancer-surgery-the-famous-pioneers-in-children
#3
Marianna Karamanou, Nikolaos Salakos, Ioannis Grammatikakis, George Androutsos
At the beginning of the 19th century, gynaecological cancer, mainly cancer of the uterus and cervix was a dreadful, incurable affection. However, the popularization of the three fundamentals in surgery, anesthesia, asepsis and haemostasis, ushered the golden age of operative gynaecology. During that period distinguished surgeons/gynaecologists such as Friedrich Benjamin Osiander (1759-1822), Elias von Siebold (1775-1828) and Joseph-Claude-Anthelme Récamier (1774-1852) contributed to the development of the operative techniques, providing a therapeutic solution in gynaecological cancer...
November 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/29331574/a-medicare-cost-analysis-of-mri-versus-ct-based-high-dose-rate-brachytherapy-of-the-cervix-can-mri-based-planning-be-less-costly
#4
Amishi Bajaj, Grant Harmon, John Weaver, Brendan Martin, Michael Mysz, Murat Surucu, John C Roeske, Andre A Konski, William Small, Matthew M Harkenrider
PURPOSE: While some institutions deliver multiple fractions per implant for MRI-based planning, it is common for only one fraction to be delivered per implant with CT-based cervical brachytherapy. The purpose of this study was to compare physician costs, hospital costs, and overall costs for cervical cancer patients treated with either CT-based or MRI-based high-dose-rate (HDR) cervical brachytherapy to determine if MRI-based brachytherapy as described can be financially feasible. METHODS AND MATERIALS: We identified 40 consecutive patients treated with curative intent cervical brachytherapy...
January 10, 2018: Brachytherapy
https://www.readbyqxmd.com/read/29327473/risk-assessment-for-metalworking-fluids-and-cancer-outcomes
#5
Robert M Park
BACKGROUND: Metalworking fluids (MWF) are complex mixtures with dermal and inhalation exposure. Published reports reveal excess cancer risk. METHODS: Using published findings exposure response was derived for each attributable cancer site. Aggregate excess lifetime risk was estimated by applying a lifetable calculation. RESULTS: Cancer sites contributing the most attributable cases were larynx, esophagus, brain, female breast, and uterine cervix...
January 12, 2018: American Journal of Industrial Medicine
https://www.readbyqxmd.com/read/29325528/knowledge-attitudes-and-practices-regarding-cervical-cancer-and-screening-among-women-visiting-primary-health-care-centres-in-bahrain
#6
Ghufran Jassim, Alaaeddin Obeid, Huda A Al Nasheet
BACKGROUND: Cervical cancer is one of the most common cancers among women, with 80% of the cases occurring in developing countries. Cervical cancer is largely preventable by effective screening programs. This has not been possible with opportunistic screening and its low use in the Kingdom of Bahrain. The objective of this study was to explore the knowledge, attitudes, and practices of women attending primary care health centres for cervical cancer screening. METHODS: This was a cross-sectional study of 300 women attending primary health care centres in Bahrain...
January 11, 2018: BMC Public Health
https://www.readbyqxmd.com/read/29324535/evaluating-the-role-of-f-18-fluorodeoxyglucose-positron-emission-tomography-computed-tomography-scanning-in-the-staging-of-patients-with-stage-iiib-cervical-carcinoma-and-the-impact-on-treatment-decisions
#7
Marguerite Morkel, Annare Ellmann, James Warwick, Hannah Simonds
OBJECTIVE: FIGO (International Federation of Gynaecology and Obstetrics) staging is currently the most widely used clinical staging system for cervical cancer; however, this staging system has many shortcomings. One of these shortcomings is that lymph nodal status, specifically the para-aortic lymph nodal status, does not get taken into account. It is known that metabolic changes occur before changes are seen on anatomical imaging, and it is therefore possible to detect metastases earlier with the help of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT)...
January 10, 2018: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/29322088/successful-management-of-persistent-lower-extremity-lymphedema-with-suction-assisted-lipectomy
#8
John P Micha, Dung H Nguyen, Bram H Goldstein
Introduction: Lower-extremity lymphedema is a significant complication attributed to gynecologic cancer surgery, potentially effectuating severe edema and discernible pain. Case report: We report on a patient who developed persistent, lower-extremity lymphedema following her treatment for cervix cancer. Despite repeated efforts to manage the lymphedema with conventional measures, the patient's condition had not markedly improved. Thereafter, she underwent a suction-assisted lipectomy that effectively resolved her symptoms...
February 2018: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29321155/plasminogen-replacement-therapy-for-the-treatment-of-children-and-adults-with-congenital-plasminogen-deficiency
#9
Amy D Shapiro, Charles Nakar, Joseph M Parker, Gary R Albert, John E Moran, Karen Thibaudeau, Neelam Thukral, Brandon M Hardesty, Pierre Laurin, Per Morten Sandset
Congenital plasminogen deficiency is caused by mutation(s) in PLG, the gene coding for production of the zymogen plasminogen, and is an ultra-rare disorder associated with abnormal accumulation or growth of fibrin-rich pseudomembranous lesions on mucous membranes, such as the conjunctiva, gingiva, and linings of the airways and genitourinary tract. Left untreated, these lesions may impair normal tissue and organ function, and impact quality of life. Plasminogen replacement therapy should provide an effective treatment of the clinical manifestations of congenital plasminogen deficiency...
January 10, 2018: Blood
https://www.readbyqxmd.com/read/29320751/uterine-rhabdomyosarcoma-in-adults
#10
Andre Pinto, Ryan M Kahn, Andrew E Rosenberg, Brian Slomovitz, Charles Matthew Quick, Michella K Whisman, Marilyn Huang
Rhabdomyosarcoma (RMS) is an aggressive mesenchymal tumor most commonly diagnosed in the pediatric population, and when occurring in adults, tends to develop in the deep soft tissue of the limbs. Primary uterine RMS comprises an even more restricted subset, with little known or reported when compared to most other gynecologic sarcomas. Our goal with this study was to retrospectively evaluate cases from two academic institutions and describe the main histopathologic findings of this rare gynecologic malignancy...
January 7, 2018: Human Pathology
https://www.readbyqxmd.com/read/29319498/safety-and-tolerance-of-cidofovir-as-a-2-gel-for-local-application-in-high-grade-cervical-intraepithelial-neoplasia-a-phase-1-investigation
#11
Michel Bossens, Maud Jost, Catherine Van Pachterbeke, Viviane De Maertelaer, Philippe Simon, Francis Frankenne, Philippe Hubert, Brigitte Evrard, Robert Snoeck
OBJECTIVES: The primary objective was to evaluate the safety and local tolerance of a topical 2% (w/w) cidofovir gel, applied directly to the cervices of women with high-grade cervical intraepithelial neoplasia (CIN 2+). The secondary objective was to evaluate the pharmacokinetics of cidofovir during the treatment. MATERIALS AND METHODS: Nine women with CIN 2+, were treated with a course of 3 g of cidofovir gel, applied locally once per week for 3 weeks in total (9 g)...
January 10, 2018: International Journal of Clinical Pharmacology and Therapeutics
https://www.readbyqxmd.com/read/29319395/initial-report-of-sentinel-lymph-node-identification-during-laparoscopic-radical-hysterectomy-using-a-new-gamma-probe-technology
#12
Shinichi Togami, Toshihiko Kawamura, Mika Fukuda, Shintaro Yanazume, Masaki Kamio, Hiroaki Kobayashi
BACKGROUND: The standard surgical procedure for early-stage cervical cancer is abdominal radical hysterectomy, including pelvic lymphadenectomy. Currently, minimally invasive surgical techniques for early cervical cancer are progressing; total laparoscopic radical hysterectomy (TLRH) is a possible alternative to abdominal surgery. In addition, sentinel node navigation surgery (SNNS), which can prevent lower limb edema, has been widely used for radical hysterectomy. MATERIALS AND METHODS: A radioisotope is injected into the uterine cervix 1 day preoperatively and surgeons carefully identify the correct sentinel lymph nodes (SLNs) to prevent picking up the cervical gamma rays during surgery...
January 10, 2018: Journal of Laparoendoscopic & Advanced Surgical Techniques. Part A
https://www.readbyqxmd.com/read/29313317/laparoscopic-excision-of-an-unusual-presentation-of-a-nabothian-cyst-case-report-and-review-of-the-literature
#13
Joseph Nassif, Hasan Nahoul, Ali Mourad, Ryan Yammine, Sally Khoury, Ali Khalil
Nabothian cysts are mucinous retention cysts formed through the accumulation of cervical mucus inside blocked cervical crypts leading to non-neoplastic mucinous cystic lesion in relation to the uterine cervix. The formation of Nabothian cysts is a common gynecological benign condition in women of reproductive age. While the presence of small-sized Nabothian cysts is usually clinically asymptomatic and requires no treatment or intervention, the diagnosis of larger Nabothian cysts can be mistaken with malignant tumors, including mucin producing carcinomas such as Adenoma malignum...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29310409/analysis-of-diagnosis-and-treatment-of-complicated-cervical-severe-adhesion-atresia-after-removal-of-endometrial-stromal-nodule-a-case-report
#14
Rui Zhang, Pei Gu, Qi Liu, Bin Li, Wenpei Bai
RATIONALE: Endometrial stromal nodule (ESN) is a rare benign endometrial stroma tumor.Experiences are helpful for avoiding and treating similar postoperative complications (cervical adhesions and atresia). PATIENT CONCERNS: When appearing in the cervical, this tumor can easily lead to complications after the surgical resection. The diagnosis and postsurgery complication of a young woman's ESN was reported here. DIAGNOSES: The postoperative pathological diagnosis was ESN...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29310145/immunohistochemical-wwox-expression-and-association-with-angiogenesis-p53-expression-cell-proliferation-and-clinicopathological-parameters-in-cervical-cancer
#15
Mariana Ataydes Leite Seabra, Eduardo Batista Cândido, Paula Vieira Teixeira Vidigal, Rivia Mara Lamaita, Angélica Nogueira Rodrigues, Agnaldo Lopes da Silva Filho
OBJECTIVE:  The current study evaluated the expression of WW domain-containing oxidoreductase (WWOX), its association with clinicopathological features and with p53, Ki-67 (cell proliferation) and CD31 (angiogenesis) expression in patients with invasive cervical squamous cell carcinoma (ICSCC). To the best of our knowledge, no other study has evaluated this association. METHODS:  Women with IB stage-ICSCC (n = 20) and women with uterine leiomyoma (n = 20) were prospectively evaluated...
January 8, 2018: Revista Brasileira de Ginecologia e Obstetrícia
https://www.readbyqxmd.com/read/29309102/variations-in-progression-and-regression-of-precancerous-lesions-of-the-uterine-cervix-on-cytology-testing-among-women-of-different-races
#16
Daniel Martingano, Audrey Renson, Alison Jane Martingano, Francis X Martingano
Background: Although not incorporated into current cervical cancer screening guidelines, racial differences are known to persist in both occurrence of and outcomes related to cervical cancer. Objective: To compare the differences in progression and regression of precancerous lesions of the uterine cervix on cervical cytologic analysis among women of different races who adhered to cervical cancer screening recommendations and follow-up. Methods: Retrospective cohort study comparing differences in precancerous lesion diagnoses for patients receiving adequate evaluation according to the American Society for Colposcopy and Cervical Pathology guidelines...
January 1, 2018: Journal of the American Osteopathic Association
https://www.readbyqxmd.com/read/29307984/early-stage-adenocarcinoma-of-cervix-with-ovarian-micrometastasis
#17
Pratibha Singh, Neha Mathur, Suyasha Vyas, Puneet Pareekh
Adenocarcinoma of cervix is a rare malignancy of cervix. It is an aggressive tumor with a high incidence of metastasis. Ovarian metastasis in early stage adenocarcinoma is rare. Metastasis is usually seen when there is some other coexisting finding. In premenopausal patient and low-risk category, ovarian metastasis is very rare. Early stage adenocarcinoma of cervix can rarely present with ovarian metastasis. Thus, radical surgery with oophorectomy is an aggressive but practical approach in these patients but may not warrant removal in all cases...
October 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29307981/assessment-of-quality-of-life-in-treated-patients-of-cancer-cervix
#18
Zakia Rahman, Uma Singh, Sabuhi Qureshi, Nisha, Kirti Srivastav, Anil Nishchal
Aim: The aim of the study was to assess the quality of life (QoL) in women suffering from cancer cervix before and after the treatment, to study various factors affecting the QoL in these women, and to evaluate the impact of treatment modalities on the QoL. Materials and Methods: Women with cervical cancer attending Department of Obstetrics and Gynecology and Department of Radiotherapy who met the eligibility criteria were interviewed with a structured questionnaire of QoL, the European Organization for Research and Treatment of Cancer QLQ30, and its Cervical Cancer Module (Cx24)...
October 2017: Journal of Mid-life Health
https://www.readbyqxmd.com/read/29307708/what-interventions-are-being-used-to-prevent-preterm-birth-and-when
#19
Yu Yang Feng, Alexander Jarde, Ye Rin Seo, Anne Powell, Nwachukwu Nwebube, Sarah D McDonald
OBJECTIVE: This study sought to determine the proportions of women at risk of preterm birth who received progesterone, elective and rescue cerclage, or pessary to prevent preterm birth, by using medical records. The authors also sought to determine whether these proportions differed among primary-, secondary-, and tertiary-level centres. METHODS: The authors conducted a retrospective cohort study and extracted data from consecutive medical charts of women with an estimated date of confinement over 3 months in primary-, secondary-, and tertiary-level centres in Southern Ontario...
January 4, 2018: Journal of Obstetrics and Gynaecology Canada: JOGC, Journal D'obstétrique et Gynécologie du Canada: JOGC
https://www.readbyqxmd.com/read/29306491/effect-of-air-bubbles-localization-and%C3%A2-migration-after-embryo-transfer%C3%A2-on%C3%A2-assisted-reproductive-technology-outcome
#20
Cem Fıçıcıoğlu, Pınar Özcan, Melis G Koçer, Mert Yeşiladalı, Oya Alagöz, Gülçin Özkara, Ahter T Tayyar, Çiğdem Altunok
OBJECTIVE: To evaluate the effect of embryo flash position and movement of the air bubbles at 1 and 60 minutes after ET on clinical pregnancy rates (PRs). DESIGN: Prospective clinical trial. SETTING: University fertility clinic. PATIENT(S): A total of 230 fresh ultrasound-guided ETs performed by a single physician (C.F.) at the IVF center of Yeditepe University Hospital between September 2016 and February 2017 were included...
January 3, 2018: Fertility and Sterility
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