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https://www.readbyqxmd.com/read/29143329/matsubara-takahashi-cervix-holding-technique-for-massive-postpartum-hemorrhage-in-patients-with-placenta-previa-with-or-without-placenta-accreta-spectrum-disorders
#1
Hironori Takahashi, Akihide Ohkuchi, Rie Usui, Hirotada Suzuki, Yosuke Baba, Shigeki Matsubara
OBJECTIVE: To determine the efficacy and safety of the Matsubara-Takahashi cervix-holding technique (MT-holding) for achieving hemostasis for postpartum hemorrhage (PPH). METHODS: The present retrospective observational study included data from deliveries that occurred between January 1, 2004, and December 31, 2014, at the Department of Obstetrics and Gynecology, Jichi Medical University, Shimotsuke, Japan. Deliveries were included where patients experienced blood loss greater than 2500 mL and MT-holding was used...
November 16, 2017: International Journal of Gynaecology and Obstetrics
https://www.readbyqxmd.com/read/29142420/exploring-the-cytotoxic-potential-of-triterpenoids-enriched-fraction-of-bacopa-monnieri-by-implementing-in-vitro-in-vivo-and-in-silico-approaches
#2
Md Nasar Mallick, Washim Khan, Rabea Parveen, Sayeed Ahmad, Sadaf, Mohammad Zeeshan Najm, Istaq Ahmad, Syed Akhtar Husain
Background: Bacopa monnieri (BM) is a herbaceous plant traditionally used from time immemorial in Ayurvedic and folklore medicines. We hypothesized that the extract of the whole plant might contain numerous molecules with having antitumor activities that could be very effective in killing of human cancer cells. Objectives: This work investigated anticancer activity of bioactive fraction of BM. Materials and Methods: The hydroalcoholic extract of BM was fractionated with different solvent, namely, hexane, dichloromethane (DCM), acetone, methanol, and water...
October 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/29140879/metastatic-endocervical-adenocarcinoma-in-a-mature-cystic-teratoma-a-case-of-a-tumor-to-tumor-metastasis
#3
Filipa Santos, Catarina Oliveira, João P Caldeira, Ana Coelho, Ana Félix
Tumor-to-tumor metastasis is a rare phenomenon defined as a to metastasis in a histologically distinct tumor. We report an unusual case of a 51-yr-old woman who presented with a cervical, bleeding lesion diagnosed as a poorly differentiated adenocarcinoma, HPV18+. Imaging studies revealed an unresectable cervical carcinoma with an associated left ovarian multicystic teratoma. A suspicious solid nodule within the teratoma was also reported. Bilateral salpingo-oophorectomy was performed before the cervical tumor was treated...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29140878/clear-cell-renal-cell-carcinoma-metastatic-to-the-gynecologic-tract-a-clinicopathologic-analysis-of-17-cases
#4
Oluwole Fadare, Mohamed M Desouki, Katja Gwin, Krisztina Z Hanley, Elke A Jarboe, Sharon X Liang, Charles M Quick, Kojo R Rawish, Andres A Roma, Wenxin Zheng, Jonathan L Hecht, Vinita Parkash, Adeboye O Osunkoya
Clear cell renal cell carcinomas (CCRCC) rarely metastasizes to the gynecologic tract. In this study, we analyzed a multi-institutional data set to provide insights into the clinical, morphologic, and immunophenotypic features of this phenomenon. Seveteen metastatic CCRCC involving the gynecologic tract [ovary/fallopian tube (n=9), vulva (n=2), uterine corpus (n=3), cervix (n=2), uterine serosa (n=1)] were analyzed. Mean patient age was 62 yr (range: 45-79 yr). Most cases (15/17) presented as a recurrence 6 to 72 mo postnephrectomy, 1 case was concurrently diagnosed, and 1 case (a cervical metastasis) was diagnosed prenephrectomy...
November 14, 2017: International Journal of Gynecological Pathology
https://www.readbyqxmd.com/read/29138988/irreversible-electroporation-of-the-uterine-cervix-in-a-rabbit-model
#5
Wei Chai, Wenlong Zhang, Zhentong Wei, Ying Xu, Jian Shi, Xiaomei Luo, Jianying Zeng, Manhua Cui, Jiannan Li, Lizhi Niu
The aim of this study was to evaluate the effects of irreversible electroporation (IRE) on the uterine cervix in a rabbit model. IRE ablation was performed in the cervices of 48 New Zealand rabbits, with one ablation lesion in each animal. Gross pathology, transmission electron microscopy, hematoxylin and eosin (H&E), Masson's trichrome (MT) stain, and terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) assays were performed at pre-set time points (0 h, 12 h, 1 d, 2 d, 4 d, 7 d, 14 d, and 28 d post-IRE)...
November 14, 2017: Biomedical Microdevices
https://www.readbyqxmd.com/read/29138758/vaginoscopy-in-ewes-utilizing-a-laparoscopic-surgical-port-device
#6
Jeremiah Easley, Desiree Shasa, Eileen Hackett
Vaginoscopy allows for diagnostic evaluation and treatment of the vaginal vault. A laparoscopic surgical port device and rigid telescope were utilized for serial vaginoscopy in 8 healthy anesthetized ewes. Vaginoscopy examinations were performed in each ewe at days 1, 14, and 28. This technique was well-tolerated and facilitated carbon dioxide vaginal inflation, complete vaginal examination, identification of the cervix, and targeted biopsy collection. No complications were encountered during or following the vaginoscopy procedures...
2017: Journal of veterinary medicine
https://www.readbyqxmd.com/read/29138519/time-to-delivery-and-delivery-outcomes-comparing-three-methods-of-labor-induction-in-7551-nulliparous-women-a-population-based-cohort-study
#7
C Lindblad Wollmann, M Ahlberg, G Petersson, S Saltvedt, O Stephansson
OBJECTIVE: Determine time-to-delivery and mode-of-delivery in labor induction among women with unripe cervix. STUDY DESIGN: 7551 nulliparous women with singleton deliveries, ⩾37 weeks, Bishop Score ⩽6, induced with dinoprostone, misoprostol or transcervical single balloon catheter. Linear regression analysis was used to estimate mean time-to-delivery with β-estimates and 95% confidence intervals with adjustments. Multivariable logistic regression analysis was used to calculate odds of cesarean delivery, instrumental vaginal delivery, maternal and neonatal outcomes...
November 2017: Journal of Perinatology: Official Journal of the California Perinatal Association
https://www.readbyqxmd.com/read/29138009/human-papillomavirus-hpv-infection-in-females-with-normal-cervical-cytology-genotyping-and-phylogenetic-analysis-among-women-in-punjab-pakistan
#8
Hafsa Aziz, Huma Iqbal, Humera Mahmood, Shazia Fatima, Muhammad Faheem, Areej Abdul Sattar, Sobia Tabassum, Sanum Napper, Syeda Batool, Nuzhat Rasheed
OBJECTIVE: Cervical cancer is the fourth most common cancer in the world, seventh overall with account for an estimated 300,000 annual deaths. HPV is the second most common cause of cervical cancer worldwide. HPV screening is not a common practice in Pakistan. The present study aims to determine the prevalence of HPV and HPV types in females with normal cytology of cervix in Upper and Lower region of Punjab Pakistan and analyze the risk factors for HPV in this region. METHOD: In this study, we performed PCR analysis for 1011 female patients with normal cytology of cervix from various districts in Punjab Province, Pakistan and risk factors for acquisition of HPV were studied...
November 11, 2017: International Journal of Infectious Diseases: IJID
https://www.readbyqxmd.com/read/29137935/prostatic-adenocarcinoma-in-the-setting-of-persistent-m%C3%A3-llerian-duct-syndrome-a-case-report
#9
Zulfia McCroskey, Tracie M Koen, David J Lim, Mukul K Divatia, Steven S Shen, Alberto G Ayala, Jae Y Ro
Persistent Müllerian Duct Syndrome (PMDS) is a form of disordered sex development in which rudimentary Müllerian structures are identified in phenotypically and genotypically normal males. It is caused by defects in the anti-Müllerian hormone (AMH) system. Since patients with PMDS present with undescended testes, testosterone production by Leydig cells later in life is often decreased. The role of androgens in prostate cancerogenesis is well known. Cryptorchid testes and diminished testosterone levels in post pubertal life in patients with PMDS play a protective role against prostate cancer, and hence, prostate cancer is a rare event in patients with PMDS...
November 11, 2017: Human Pathology
https://www.readbyqxmd.com/read/29136026/operative-technique-at-caesarean-delivery-and-risk-of-complete-uterine-rupture-in-a-subsequent-trial-of-labour-at-term-a-registry-case-control-study
#10
Dorthe L A Thisted, Laust H Mortensen, Lone Hvidman, Lone Krebs
OBJECTIVE: To estimate the relation of single-layer closure at previous caesarean delivery, and other pre-labour and intra-partum risk factors for complete uterine rupture in trial of vaginal birth after a caesarean (TOLAC) at term. STUDY DESIGN: Population-based case-control study. We identified all women (n = 39 742) recorded in the Danish Medical Birth Registry (DMBR) during a 12-year period (1997-2008) with a singleton pregnancy at term and TOLAC. Among these, all women with a complete uterine rupture were identified (cases)...
2017: PloS One
https://www.readbyqxmd.com/read/29134627/the-evolution-of-genital-shape-variation-in-female-cetaceans
#11
Dara N Orbach, Brandon Hedrick, Bernd Würsig, Sarah L Mesnick, Patricia Lr Brennan
Male genital diversification is likely the result of sexual selection. Female genital diversification may also result from sexual selection, although it is less well studied and understood. Female genitalia are complex among whales, dolphins, and porpoises, especially compared to other vertebrates. The evolutionary factors affecting the diversity of vaginal complexity could include ontogeny, allometry, phylogeny, sexual selection, and natural selection. We quantified shape variation in female genitalia using 2-D geometric morphometric analysis, and validated the application of this method to study soft tissues...
November 14, 2017: Evolution; International Journal of Organic Evolution
https://www.readbyqxmd.com/read/29134441/correction-to-abstracts-29th-european-congress-of-pathology
#12
S Lopes Petronilho, D Montezuma, R Vieira, A L Cunha, R Henrique, C Bartosch
In Oral Free Paper Sessions, the first-author name was missing from the authorship group originally listed for Abstract OFP-04-012 (page S14), entitled "Differentiating primary pulmonary squamous cell carcinoma from squamous cell carcinoma of the cervix metastatic to the lung: Histological and immunohistochemistry study".
November 14, 2017: Virchows Archiv: An International Journal of Pathology
https://www.readbyqxmd.com/read/29133151/laparoscopic-management-of-a-rudimentary-uterine-horn
#13
Emilie Faller, Jean Jacques Baldauf, François Becmeur, Anne Lehn, Cherif Youssef Akladios, Lise Lecointre
STUDY OBJECTIVE: To demonstrate a technique of laparoscopic management of a rudimentary horn in a 12-year-old girl. DESIGN: A step-by-step explanation of the surgery using video (instructive video), approved the local institutional Review Board. SETTING: A university hospital, University Hospital of Strasbourg, France. PATIENT: A 12-year-old girl with a uterine rudimentary horn. INTERVENTION: We describe the case of a 12 years old girl who had no medical history...
November 10, 2017: Journal of Minimally Invasive Gynecology
https://www.readbyqxmd.com/read/29130109/deubiquitinase-usp9x-promotes-cell-migration-invasion-and-inhibits-apoptosis-of-human-pancreatic-cancer
#14
Li Liu, Dan Yao, Pengbo Zhang, Weichao Ding, Xiuzhong Zhang, Chong Zhang, Shuai Gong, Yi Zhang, Jike Wang, Ting Sun, Zeqiang Ren
Ubiquitin specific peptidase 9, X-linked (USP9X), a significant regulatory protease in protein ubiquitination, has been proven to act as a proto-oncogene in several types of cancers, such as cervix, colon, breast, brain and lung cancers. The prognosis of patients with pancreatic ductal adenocarcinoma (PDAC) is extremely poor due to its high invasive and metastatic abilities. Nevertheless, whether USP9X acts as a proto-oncogene or a tumor-suppressor gene in PDAC is controversial and the mechanism of metastasis remains unknown...
December 2017: Oncology Reports
https://www.readbyqxmd.com/read/29129514/a-green-multicomponent-synthesis-of-tocopherol-analogues-with-antiproliferative-activities
#15
Mariana Ingold, Rosina Dapueto, Sabina Victoria, Germán Galliusi, Carlos Batthyàny, Mariela Bollati-Fogolín, David Tejedor, Fernando García-Tellado, José M Padrón, Williams Porcal, Gloria V López
A one-pot efficient, practical and eco-friendly synthesis of tocopherol analogues has been developed using water or solvent free conditions via Passerini and Ugi multicomponent reactions. These reactions can be optimized using microwave irradiation or ultrasound as the energy source. Accordingly, a small library of 30 compounds was prepared for biological tests. The evaluation of the antiproliferative activity in the human solid tumor cell lines A549 (lung), HBL-100 (breast), HeLa (cervix), SW1573 (lung), T-47D (breast), and WiDr (colon) provided lead compounds with GI50 values between 1 and 5 μM...
November 3, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29121417/transabdominal-cerclage-tac-for-patients-with-ultra-short-uterine-cervix-after-uterine-cervix-surgery-and-its-impact-on-pregnancy
#16
Shinichi Ishioka, Miseon Kim, Yuko Mizugaki, Saori Kon, Kyoko Isoyama, Masahito Mizuuchi, Miyuki Morishita, Tsuyoshi Baba, Takao Sekiya, Tsuyoshi Saito
AIM: Patients with an ultra-short uterine cervix as a result of large conization, repeated conization or radical trachelectomy (RT), are at high risk of preterm premature rupture of the membrane, which leads to preterm birth. We have commenced performing transabdominal cerclage (TAC) of the uterine cervix for these patients. In this study, we examined the safety of TAC and its impact on pregnancy. METHODS: We have performed TAC in 11 patients before pregnancy: in six after large cervical operations, such as repeated conization; and in five for difficulties with cervical cerclage after RT...
November 9, 2017: Journal of Obstetrics and Gynaecology Research
https://www.readbyqxmd.com/read/29120029/safety-and-effectiveness-of-labour-induction-after-caesarean-section-using-balloon-catheter-or-oxytocin
#17
Anda-Petronela Radan, Sofia Amylidi-Mohr, Beatrix Mosimann, Cedric Simillion, Luigi Raio, Martin Mueller, Daniel Surbek
AIMS OF THE STUDY: Induction of labour after previous caesarean section (CS) is a challenge for obstetricians due to the increased risk of uterine rupture. Common methods for labour induction are balloon catheters and oxytocin as they are considered safe. However, the effectiveness remains unclear as currently available data are limited. Therefore, we aimed to determine safety and effectiveness of balloon catheter or oxytocin for labour induction after CS. METHODS: We included 179 consecutive women with a previous CS and labour induction in this retrospective study...
November 9, 2017: Swiss Medical Weekly
https://www.readbyqxmd.com/read/29118475/histological-follow-up-in-patients-with-atypical-glandular-cells-on-pap-smears
#18
Gokhan Boyraz, Derman Basaran, Mehmet Coskun Salman, Akbar Ibrahimov, Sevgen Onder, Orkun Akman, Nejat Ozgul, Kunter Yuce
Context: Atypical glandular cells (AGCs) result in the Papanicolaou (Pap) smear may be associated with significant genital and nongenital neoplastic processes. Aims: To evaluate the underlying histopathology in women who had AGCs on Pap smears. Settings and Design: Retrospective cross-sectional study. Patients and Methods: Clinicopathological data of patients who had AGC on Pap smears and underwent histological workup between January 2004 and December 2014 were retrieved from the computerized database of a tertiary care center...
October 2017: Journal of Cytology
https://www.readbyqxmd.com/read/29115509/microrna%C3%A2-211-suppresses-the-growth-and-metastasis-of-cervical-cancer-by-directly-targeting-zeb1
#19
Guangyuan Chen, Ping Huang, Jiabin Xie, Rihong Li
Of gynecological cancers, cervical cancer has the second highest incidence globally and is a major cause of cancer‑associated mortality in women. An increasing number of studies have reported that microRNAs (miRNAs) have important roles in cervical cancer carcinogenesis and progression through regulation of various critical protein‑coding genes. The aim of the present study was to investigate the expression and biological roles of miRNA‑211 (miR‑211) in cervical cancer and its underlying molecular mechanism...
November 7, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/29115079/disparities-by-age-sex-tumor-stage-diagnosis-path-and-area-level-socioeconomic-status-in-survival-time-for-major-cancers-results-from-the-busan-cancer-registry
#20
Minjung Kwak, Changhoon Kim
Our goal was to examine the effect of area-level deprivation on patient survival time for seven major cancers - stomach, colon, liver, lung, breast, cervix, and thyroid cancer. Data on 10,902 subjects who were diagnosed with major cancers from 2010 and 2011 in Busan were collected regarding the survival time along with several important prognostic factors and an area-level deprivation index was constructed from education, income, unemployment, and welfare assistance, to assess the comprehensive area-level socioeconomic status...
December 2017: Journal of Korean Medical Science
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