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Pedro Nazareth Aguiar, Gustavo Trautman Stock, Gilberto de Lima Lopes, Michelle Samora de Almeida, Hakaru Tadokoro, Bárbara de Souza Gutierres, Douglas Antônio Rodrigues
Objective: To assess aspects related to cancer in indigenous population. Methods: This is a retrospective study developed in a public university hospital. We included patients with 18 or more years of age, diagnosed with solid tumors, and followed between 2005 and 2015. Clinical features were assessed by descriptive statistics, and survival was evaluated by Kaplan-Meier curves and multivariate Cox regression. Results: Fifty patients were included...
July 2016: Einstein
Wan-Ru Chao, Chi-Kuan Chen, Lih-Min Han, Chih-Ping Han
No abstract text is available yet for this article.
October 2016: Taiwanese Journal of Obstetrics & Gynecology
Roberto Anaya-Prado, Manuel Fernando Barba-Anaya, Jorge Manuel Sánchez-González, Michelle Marie Anaya-Fernández, Ana Bertha Zavalza-Gómez, Francisco Gil-Villarreal, Alejandro Bravo-Cuellar, Andrea Del Carmen Grijalva-Solis
Studies have shown that triggering receptor expressed on myeloid cells-1 (TREM-1) is the mediator and activator of neutrophils and monocytes after stimulation with lipopolysaccharide (LPS), heat-inactivated Gram (-) bacteria, Gram (+) bacteria or fungi. Different studies have measured the expression of TREM-1 in patients with bacterial infections and critical states. The purpose of this study was to evaluate the expression of TREM-1 in circulating maternal leukocytes in premature rupture of the membranes (PRM)...
October 18, 2016: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Anabela Rocha, Ana Maria Domínguez, Fabrice Lécuru, Nicolas Bourdel
OBJECTIVE: Sentinel lymph node (SLN) mapping for endometrial (EC) and cervical cancers (CC) is a current technique that could provide benefits over traditional lymphadenectomy. Near-infrared (NIR) fluorescence imaging is a promising technique to perform this procedure. We conducted a systematic review of the evidence regarding the technique and the effectiveness of indocyanine green (ICG) during SLN biopsy, using robotic and laparoscopic assisted surgery and laparotomy. MATERIALS AND METHODS: We conducted a computer literature search for published English language studies in humans using PubMed since January 2010 up to May 2015...
September 30, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Florence van Hunsel, Sonja van de Koppel, Eugène van Puijenbroek
Two 54-year-old women developed abdominal cramps and vaginal hemorrhage as a result of endometrial hyperplasia during treatment with a hop-containing phytotherapeutic product (MenoCool(®)) for post-menopausal complaints. The women used the hop-containing phytotherapeutic product (418 mg of hop per tablet) twice daily (1 and 0.5 tablets by both patient A and B). Patient A developed abdominal cramps and vaginal hemorrhage after 2 months of use. After gynecological examination, she was diagnosed with endometrial hyperplasia...
December 2015: Drug Saf Case Rep
Harneet Gujral, Annmarie Vilkins, Nisse Clark, Alison B Vogell, Kelly N Wright
STUDY OBJECTIVE: To compare the operative time of contained hand tissue extraction to power morcellation and to quantify the learning curve required to develop this skill. DESIGN: Retrospective cohort study DESIGN: Classification: II-3 SETTING: Lahey Hospital and Medical Center, a suburban academic tertiary care center serving a broad base of patients. PATIENTS: Eighty-eight women undergoing laparoscopic hysterectomy requiring morcellation or tissue extraction from 2012 through 2015...
October 13, 2016: Journal of Minimally Invasive Gynecology
Eric Leblanc, Fabrice Narducci, Lucie Bresson, Delphine Hudry
OBJECTIVE: To explore the feasibility of an oncologically acceptable management for an intermediate-risk endometrial cancer (EC) in an elderly, using the combination of transvaginal single-port laparoscopy and sentinel node policy. METHODS: For this 85-years old patient, BMI 32kg/m(2), with IB grade 2 endometrioid EC, a single vaginal approach was attempted [1] to perform a total hysterectomy, bilateral salpinago-oophorectomy and pelvic node assessment guided by SND [2]...
October 13, 2016: Gynecologic Oncology
Joannie Lortet-Tieulent, Isabelle Soerjomataram, Chun Chieh Lin, Jan Willem W Coebergh, Ahmedin Jemal
INTRODUCTION: In the U.S., people of different races/ethnicities have differences in cancer incidence, mortality, survival, stage at diagnosis, and receipt of treatment, resulting in variances in cancer burden. The burden of cancer in 2011 was assessed by race/ethnicity for 24 cancers using disability-adjusted life years (DALYs). METHODS: In 2014-2015, DALYs and their two components were estimated (years of life lost [YLLs] and years lived with disability) by race/ethnicity using population-based cancer registry data collected in 2013, vital statistics, and literature reviews...
November 2016: American Journal of Preventive Medicine
N D Fleming, P T Ramirez, P T Soliman, K M Schmeler, G B Chisholm, A M Nick, S N Westin, M Frumovitz
OBJECTIVES: To longitudinally assess quality of life (QOL) in women undergoing radical trachelectomy for early-stage cervical cancer. METHODS: We prospectively enrolled patients with stage IA1-IB1 cervical cancer prior to undergoing radical trachelectomy to complete validated QOL instruments. These instruments included the General Health-Related QOL (SF-12), Functional Assessment of Cancer Therapy-Cervix (FACT-Cx), MD Anderson Symptom Inventory (MDASI), Female Sexual Functioning Index (FSFI), and Satisfaction with Decision scale (SWD)...
October 11, 2016: Gynecologic Oncology
Jing Rui Tang, Nor Ashidi Mat Isa, Ewe Seng Ch'ng
Pap test involves searching of morphological changes in cervical squamous epithelial cells by pathologists or cytotechnologists to identify potential cancerous cells in the cervix. Nuclear membrane irregularity is one of the morphological changes of malignancy. This paper proposes two novel techniques for the evaluation of nuclear membrane irregularity. The first technique, namely, penalty-driven smoothing analysis, introduces different penalty values for nuclear membrane contour with different degrees of irregularity...
2016: PloS One
Donghong Li, Lihong Chen, Huifang Wang, Hongli Yang, Yuping Dai, Cuige Yu, Yun Dong
AIM: A newly developed cervical cancer screening method - folate receptor-mediated epithelium staining utilizes methylene blue internalized by folate receptor-mediated endocytosis to stain cervical intra-epithelial neoplasia. We test the clinical feasibility of this method in this study. METHODS: A total of 14 344 women who were at least 21 years old and had been sexually active, participated in the study. In gynecological clinics, participants underwent cervical cancer screening with folate receptor-mediated epithelium staining followed by cytology sampling...
October 14, 2016: Asia-Pacific Journal of Clinical Oncology
A Mas, L Stone, P M O'Connor, Q Yang, D T Kleven, C Simon, C L Walker, A Al-Hendy
Despite the high prevalence and major negative impact of uterine fibroids (UFs) on women's health, their pathogenesis remains largely unknown. While tumor initiating cells (TICs) have been previously isolated from UFs, the cell of origin for these tumors in normal myometrium has not been identified. We isolated cells with Stro1/CD44 surface markers from normal myometrium expressing stem cell markers Oct-4/c-kit/nanog that exhibited the properties of myometrial stem/progenitor-like cells (MSCs). Using a murine model for UFs, we showed that the cervix was a hypoxic "niche" and primary site (96%) for fibroid development in these animals...
October 14, 2016: Stem Cells
Ali N Russell, Xiaojing Zheng, Catherine M O'Connell, Harold C Wiesenfeld, Sharon L Hillier, Brandie D Taylor, Michelle Picard, Jessica Flechtner, Wujuan Zhong, Lauren C Frazer, Toni Darville
BACKGROUND:  Natural infection induces partial immunity to Chlamydia trachomatis Identification of chlamydial antigens that induce interferon-γ secretion by T cells of immune women could advance vaccine development. METHODS:  Interferon-γ production by CD4 and CD8 peripheral blood T cells from 58 high-risk women was measured after co-culture with antigen presenting cells preincubated with recombinant Escherichia coli expressing a panel of 275 chlamydial antigens...
October 12, 2016: Journal of Infectious Diseases
Tilde B Østborg, Pål R Romundstad, Torbjørn M Eggebø
INTRODUCTION: The aim of the study was to compare the duration of active phase of labor in women with spontaneous or induced start of labor. MATERIAL AND METHODS: An observational cohort study was performed at Stavanger University Hospital in Norway between January 2010 and December 2013 and 19 524 women delivered during the study period. Data for the study were collected from an electronic birth journal. Women with previous cesarean section, multiple pregnancy, breech or transverse lie, preterm labor or prelabor cesarean section were excluded...
October 12, 2016: Acta Obstetricia et Gynecologica Scandinavica
Álvaro Marín-Hernández, José S Rodríguez-Zavala, Isis Del Mazo-Monsalvo, Sara Rodríguez-Enríquez, Rafael Moreno-Sánchez, Emma Saavedra
Glycolysis provides precursors for the synthesis of macromolecules and may contribute to the ATP supply required for the constant and accelerated cellular duplication in cancer cells. In consequence, inhibition of glycolysis has been reiteratively considered as an anti-cancer therapeutic option. In previous studies, kinetic modeling of glycolysis in cancer cells allowed the identification of the main steps that control the glycolytic flux: glucose transporter, hexokinase (HK), hexose phosphate isomerase (HPI), and glycogen degradation in human cervix HeLa cancer cells and rat AS-30D ascites hepatocarcinoma...
2016: Frontiers in Physiology
Taneeru Sravya, Guttikonda Venkateswara Rao, Manchikatla Praveen Kumar, K Sudheerkanth
Adenosquamous carcinoma (ASC) of the head and neck (H and N) is an aggressive variant of squamous cell carcinoma (SCC). They are described as SCC subtype with high infiltrative capacity and also presents with dual histomorphology, having both squamous and glandular cell components. ASC of the H and N region is considered as a controversial tumor, as it is similar to salivary gland mucoepidermoid carcinoma. It has been described in a variety of body sites, including uterine cervix, lung and pancreas. ASC rarely develops in the upper aerodigestive tract, particularly in the oral cavity...
September 2016: Journal of Oral and Maxillofacial Pathology: JOMFP
Anneliese Velez-Perez, Xiaohong I Wang, Min Li, Songlin Zhang
Invasive squamous cell carcinoma (SCC) of the cervix involves the progression of premalignant cervical intraepithelial neoplasia (CIN) and is associated with persistent human papilloma virus (HPV) infection. Most CINs will regress, and the challenge is to identify the lesions likely to progress to invasive cancer. We evaluated Sirtuin1 (SIRT1) expression in non-neoplastic cervix, CINs and SCC as a potential biomarker to predict disease progression. A total of 101 cases were selected including 29 CIN 1, 32 CIN 2, 16 CIN 3, 2 microinvasive SCC and 22 invasive SCC...
October 6, 2016: Human Pathology
Jason A Jarzembowski
Dr. Louis "Pepper" Dehner is an internationally renowned surgical pathologist, especially in the subspecialty of pediatric pathology. Although his clinical and academic expertise are broad, with over 400 published articles, some of his most intriguing contributions have been in the area of pediatric renal and genitourinary pathology. This review focuses on the entities in these following organ systems where he has focused his efforts: malignant rhabdoid tumor, renal medullary carcinoma, Ewing sarcoma/peripheral neuroectodermal tumor, and the DICER1-related lesions cystic nephroma, embryonal rhabdomyosarcoma of the uterine cervix, and Sertoli-Leydig cell tumor...
August 31, 2016: Seminars in Diagnostic Pathology
Satoshi Koyama, Yosuke Nakamura, Yuko Yokoyama, Tsuyoshi Morisaki, Takahiro Fukuhara, Kazunori Fujiwara, Hiroya Kitano, Hiromi Takeuchi
Basaloid squamous cell carcinoma (BSCC) is a histologically distinctive variant of squamous cell carcinoma comprising basal cell carcinoma and squamous cell carcinoma. BSCC is aggressive and shows a poor prognosis because of frequent lymph node invasion and distant metastases. BSCC preferentially occurs in the cervix, thymus, and esophagus and is uncommonly found in the head and neck region. BSCC in the nasal cavity or paranasal sinus is particularly rare. Inverted papilloma is an uncommon, benign tumor with a propensity to be associated with malignancy; however, BSCC arising in an inverted papilloma has never been reported...
October 6, 2016: Auris, Nasus, Larynx
Giovanni Grandi, Lucrezia Pignatti, Francesca Ferrari, Giulia Dante, Isabella Neri, Fabio Facchinetti
INTRODUCTION: Inflammation might be an important underlying cause of preterm birth. Our aim is to explore whether vaginal administration α-lipoic acid reduces cervical inflammation and shortening after primary tocolysis. Matherials and Methods: Singleton pregnancies between 24-30 weeks remaining undelivered after hospitalization for preterm labor were randomly allocated to placebo (20 women, 15 analyzed) or vaginal ALA 400 mg daily (20 women, 17 analyzed) for 30 days. A cervical swab to quantify pro-inflammatory (IL1, IL2, IL6, IL8, TNFα) and anti-inflammatory (IL4, IL10) cytokines as well as transvaginal ultrasound cervical length measurement (CL) were performed before and after treatment...
October 9, 2016: Journal of Maternal-fetal & Neonatal Medicine
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