Yuan Gao, Yajuan Fan, Zai Yang, Qingyan Ma, Binbin Zhao, Xiaoyan He, Fengjie Gao, Li Qian, Wei Wang, Ce Chen, Yunchun Chen, Chengge Gao, Xiancang Ma, Feng Zhu
Evidence suggests that complex interactions between the immune system and brain have important etiological and therapeutic implications in schizophrenia. However, the detailed cellular and molecular basis of immune dysfunction in schizophrenia remains poorly characterized. To better understand the immune changes and molecular pathways, we systemically compared the cytokine responses of peripheral blood mononuclear cells (PBMCs) derived from patients with schizophrenia and controls against bacterial, fungal, and purified microbial ligands, and identified aberrant cytokine response patterns to various pathogens, as well as reduced cytokine production after stimulation with muramyl dipeptide (MDP) in schizophrenia...
February 2022: Molecular Psychiatry