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insight in schizophrenic patients

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https://www.readbyqxmd.com/read/29701937/mediation-analyses-of-insight-quality-of-life-depression-and-suicidality-results-from-the-face-sz-cohort
#1
Paul Roux, David Misdrahi, Delphine Capdevielle, Bruno Aouizerate, Fabrice Berna, Lore Brunel, Isabelle Chereau, Jean-Michel Dorey, Caroline Dubertret, Julien Dubreucq, Catherine Faget-Agius, Sandrine Fonteneau, Franck Gabayet, Pierre Michel Llorca, Jasmina Mallet, Romain Rey, Raphaëlle Richieri, Aurélie Schandrin, Franck Schürhoff, Arnaud Tessier, Pierre Vidailhet, Christine Passerieux, Mathieu Urbach
OBJECTIVE: The relationship between greater insight and increased risk of suicide in patients with schizophrenia is debated. The purpose of this study was to assess whether quality of life (QoL) and depression mediated the association between insight and suicidality. METHODS: Between March 2010 and December 2015, 527 community-dwelling adults with stable schizophrenia according to DSM-IV criteria were included in a multicenter cross-sectional study, the FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) Study...
April 17, 2018: Journal of Clinical Psychiatry
https://www.readbyqxmd.com/read/29492362/clozapine-improvement-of-negative-symptoms-of-schizophrenia
#2
Afaque H Khan, Samina Zaidi
We report five cases of treatment-resistant schizophrenia that presented with prominent negative and positive symptoms. They fulfill the criteria of diagnosis of schizophrenia according to the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5). They showed lack of response despite receiving multiple trials of first and second generation psychotropic agents. We decided to give these patients a trial of clozapine to improve their negative and positive symptoms as well as their quality of life...
December 20, 2017: Curēus
https://www.readbyqxmd.com/read/29488894/-poor-insight-and-psychosis
#3
O Giotakos
A variety of phenomena might be considered as reflecting impaired insight in psychosis, like failure to recognize signs, symptoms or disease, failure to derive appropriate cognitive representations, despite recognition of the disease, and misattribution of the source or cause of the disease. The unawareness of tardive dyskinesia symptoms in schizophrenic patients points that self-awareness deficits in schizophrenia may be domain specific. Poor insight is an independent phenomenological and a prevalent feature in psychotic disorders in general, and in schizophrenia in particular, but we don't know yet if delusions in schizophrenia are the result of an entirely normal attempt to account for abnormal perceptual experiences or a product of abnormal experience but of normal reasoning...
October 2017: Psychiatrikē, Psychiatriki
https://www.readbyqxmd.com/read/29467926/distinct-pattern-of-cerebral-blood-flow-alterations-specific-to-schizophrenics-experiencing-auditory-verbal-hallucinations-with-and-without-insight-a-pilot-study
#4
Rixing Jing, Jiangjie Huang, Deguo Jiang, Xiaodong Lin, Xiaolei Ma, Hongjun Tian, Jie Li, Chuanjun Zhuo
Schizophrenia is associated with widespread and complex cerebral blood flow (CBF) disturbance. Auditory verbal hallucinations (AVH) and insight are the core symptoms of schizophrenia. However, to the best of our knowledge, very few studies have assessed the CBF characteristics of the AVH suffered by schizophrenic patients with and without insight. Based on our previous findings, Using a 3D pseudo-continuous ASL (pcASL) technique, we investigated the differences in AVH-related CBF alterations in schizophrenia patients with and without insight...
January 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29317600/altered-avalanche-dynamics-in-a-developmental-nmdar-hypofunction-model-of-cognitive-impairment
#5
Saurav Seshadri, Andreas Klaus, Daniel E Winkowski, Patrick O Kanold, Dietmar Plenz
Disturbed activity patterns in cortical networks contribute to the pathophysiology of schizophrenia (SZ). Several lines of evidence implicate NMDA receptor hypofunction in SZ, and blocking NMDA receptor signaling during early neurodevelopment produces cognitive deficits in rodent models that resemble those seen in schizophrenic patients. However, the altered network dynamics underlying these cognitive impairments largely remain to be characterized, especially at the cellular level. Here, we use in vivo two-photon calcium imaging to describe pathological dynamics, occurring in parallel with cognitive dysfunction, in a developmental NMDA receptor hypofunction model...
January 10, 2018: Translational Psychiatry
https://www.readbyqxmd.com/read/29310360/achieving-stable-remission-with-maintenance-electroconvulsive-therapy-in-a-patient-with-treatment-resistant-schizophrenia-a-case-report
#6
Sebastian Moeller, Neele Kalkwarf, Caroline Lücke, Diana Ortiz, Sonja Jahn, Christiane Först, Niclas Braun, Alexandra Philipsen, Helge H O Müller
RATIONALE: Up to one third of all schizophrenic patients are classified as having treatment-resistant schizophrenia (TRS). This subgroup faces remarkable medical and psychosocial damages, and pharmacotherapy is often limited due to nonresponse and/or side effects. Maintenance electroconvulsive therapy (M-ECT) might be effective in TRS. PATIENT CONCERNS: We present a case of a 26-year-old male patient with a TRS. DIAGNOSES: He received a treatment series of ECT sessions and a course of 24 M-ECTs...
December 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29195803/-validation-of-the-french-version-of-the-self-evaluation-of-negative-symptoms-sns
#7
C Hervochon, V Bourgeois, M Rotharmel, J-B Duboc, B Le Goff, P Quesada, D Campion, S Dollfus, O Guillin
INTRODUCTION: Schizophrenia is a disorder affecting 1% of the population and is associated with severe functional impairment. Negative symptoms are responsible for the majority of this impairment, and many patients with schizophrenia have negative symptoms. However, their evaluation is still a challenge. Thus, standardized assessments are needed to facilitate identification of these symptoms. Many tools have been developed, but most are based on observer ratings. Self-evaluation can provide an additional outcome measure and allow patients to be more engaged in their treatment...
November 28, 2017: L'Encéphale
https://www.readbyqxmd.com/read/29073600/new-insight-into-affectivity-in-schizophrenia-from-the-phenomenology-of-marc-richir
#8
Tudi Gozé, Till Grohmann, Jean Naudin, Michel Cermolacce
BACKGROUND: According to Karl Jaspers, psychopathology requires a comprehensive method, understood as a systematic exploration of the first-person perspective of the patient's experience. At the same time, however, schizophrenia for Jaspers is characterized by its radical incomprehensibility. In addition, Rümke's so-called "praecox feeling" paradoxically combines the incomprehensibility of schizophrenic experience and the evidence of its pathological manifestation in the encounter...
2017: Psychopathology
https://www.readbyqxmd.com/read/29038553/a-comparison-of-passive-and-active-estimates-of-sleep-in-a-cohort-with-schizophrenia
#9
Patrick Staples, John Torous, Ian Barnett, Kenzie Carlson, Luis Sandoval, Matcheri Keshavan, Jukka-Pekka Onnela
Sleep abnormalities are considered an important feature of schizophrenia, yet convenient and reliable sleep monitoring remains a challenge. Smartphones offer a novel solution to capture both self-reported and objective measures of sleep in schizophrenia. In this three-month observational study, 17 subjects with a diagnosis of schizophrenia currently in treatment downloaded Beiwe, a platform for digital phenotyping, on their personal Apple or Android smartphones. Subjects were given tri-weekly ecological momentary assessments (EMAs) on their own smartphones, and passive data including accelerometer, GPS, screen use, and anonymized call and text message logs was continuously collected...
October 16, 2017: NPJ Schizophrenia
https://www.readbyqxmd.com/read/29036672/convergence-and-divergence-of-brain-network-dysfunction-in-deficit-and-non-deficit-schizophrenia
#10
Miao Yu, Zhengjia Dai, Xiaowei Tang, Xiang Wang, Xiaobin Zhang, Weiwei Sha, Shuqiao Yao, Ni Shu, Xindi Wang, Jiaying Yang, Xiangyang Zhang, Xiangrong Zhang, Yong He, Zhijun Zhang
Deficit schizophrenia (DS), characterized by primary and enduring negative symptoms, has been considered as a pathophysiologically distinct schizophrenic subgroup. Neuroimaging characteristics of DS, especially functional brain network architecture, remain largely unknown. Resting-state functional magnetic resonance imaging and graph theory approaches were employed to investigate the topological organization of whole-brain functional networks of 114 male participants including 33 DS, 41 non-deficit schizophrenia (NDS) and 40 healthy controls (HCs)...
October 21, 2017: Schizophrenia Bulletin
https://www.readbyqxmd.com/read/28936154/potential-role-of-amino-acids-in-pathogenesis-of-schizophrenia
#11
REVIEW
Shamaila Saleem, Faiza Shaukat, Anjuman Gul, Mahwish Arooj, Arif Malik
Schizophrenia is a syndrome of inconclusive etiopathogenesis with a prevalence of about 1% in general population. Underlying factors include genetic predisposition and defected neurodevelopment in early stages of life. The role of amino acids has been indicated in some reports. However, very few workers have detailed the effect of each amino acid in the pathophysiology of schizophrenia. Thus, in the present review, we aimed to provide an insight into the potential role of amino acids levels during schizophrenia...
July 2017: International Journal of Health Sciences
https://www.readbyqxmd.com/read/28870686/-risk-factors-related-to-homicide-in-moroccan-patients-with-schizophrenia
#12
A Kachouchi, M Sebbani, S Salim, I Adali, F Manoudi, M Amine, F Asri
BACKGROUND: Persons with schizophrenia are thought to be at increased risk of committing violent crime - 4 to 6 times the level of general population individuals without this disorder. The relationship between schizophrenia and homicide is complex and cannot be reduced to a simple causal link. OBJECTIVES: The objectives of this study were to describe the characteristics of homicide in Moroccan patients suffering from schizophrenia and to determine the correlated sociodemographic, clinical and toxic variables...
September 1, 2017: L'Encéphale
https://www.readbyqxmd.com/read/28701821/an-exploratory-study-of-intensive-neurofeedback-training-for-schizophrenia
#13
Wenya Nan, Feng Wan, Lanshin Chang, Sio Hang Pun, Mang I Vai, Agostinho Rosa
Schizophrenia is a chronic and devastating brain disorder with ongoing cognitive, behavioral, and emotional deteriorated functions. Neurofeedback training, which enables the individuals to regulate their brain activity using a real-time feedback loop, is increasingly investigated as a potential alternative intervention for schizophrenia. This study aimed to explore the effect of short but intensive neurofeedback training for schizophrenic patients with difficulty for long-time training. A middle-aged woman with chronic schizophrenia completed the intensive training of alpha/beta2 (20-30 Hz) in four consecutive days with a total training duration of 13...
2017: Behavioural Neurology
https://www.readbyqxmd.com/read/28181189/deficit-but-not-nondeficit-schizophrenia-is-characterized-by-mucosa-associated-activation-of-the-tryptophan-catabolite-trycat-pathway-with-highly-specific-increases-in-iga-responses-directed-to-picolinic-xanthurenic-and-quinolinic-acid
#14
Buranee Kanchanatawan, Sunee Sirivichayakul, Kiat Ruxrungtham, André F Carvalho, Michel Geffard, Heidi Ormstad, George Anderson, Michael Maes
Evidence suggests that activation of the tryptophan catabolite (TRYCAT) pathway is involved in the pathophysiology of schizophrenia. However, no previous study examined whether TRYCAT pathway activation is associated with deficit schizophrenia. We measured IgA responses to TRYCATs, namely quinolinic acid, picolinic acid, kynurenic acid, xanthurenic acid, and anthranilic acid and 3-OH-kynurenine, in 40 healthy controls and in schizophrenic patients with (n = 40) and without (n = 40) deficit, defined according to the Schedule for the Deficit Syndrome (SDS)...
February 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/28160655/factors-associated-with-complete-discontinuation-of-medication-among-patients-with-schizophrenia-in-the-year-after-hospital-discharge
#15
Yanling Zhou, Robert Rosenheck, Somaia Mohamed, Yuping Ning, Hongbo He
Medication discontinuation is a major risk factor for relapse in schizophrenic patients. The present study investigated the rate and clinical correlates of complete medication discontinuation in the year after hospital discharge. Data collected from 236 schizophrenia patients who were prescribed anti-psychotics documented socio-demographic characteristics, symptom severity, insight, and attitudes towards medication in the week before their discharge and the experience of caregiver burden for their primary caregiver as recorded at the time of hospitalization...
April 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28064092/effects-of-self-and-familiarity-on-change-detection-in-patients-with-schizophrenia
#16
Anna Kochs, Stephan Köhler, Holger Merz, Philipp Sterzer
In schizophrenia, processing of self-related stimuli has been shown to be altered. It is unclear whether altered self-processing in schizophrenia is confined to cognitive functions such as self-recognition, or whether it pertains to automatic lower-level perceptual processes. Visual face processing was tested in patients with schizophrenia (n=36) and healthy controls (n=33). Using a change detection paradigm (self, famous, unknown faces), we tested whether self-related stimuli gain access to awareness preferentially...
February 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27663045/-predictors-of-medication-non-adherence-among-a-moroccan-sample-of-patients-with-schizophrenia-a-cross-sectional-study
#17
A El Ammouri, H Kisra
BACKGROUND: Schizophrenia is a chronic, relapsing, mental disorder, and lack of adherence is a common and severe problem in such patients leadingto global and heavy consequences for patients (relapses, hospitalizations, impaired quality of life…), for the family and for society. Improved understanding of the underlying reasons will help to form intervention strategies relevant to the context. OBJECTIVES: We aimed to assess medication adherence among stable patients suffering from schizophrenia and to identify factors associated with non-adherence...
December 2017: L'Encéphale
https://www.readbyqxmd.com/read/27658989/-therapeutic-benefit-of-a-registered-psychoeducation-program-on-treatment-adherence-objective-and-subjective-quality-of-life-french-pilot-study-for-schizophrenia
#18
F Sauvanaud, O Kebir, M Vlasie, V Doste, I Amado, M-O Krebs
INTRODUCTION: In schizophrenic disorders, supportive psychosocial therapies have been used as adjuncts to pharmacotherapy to help alleviate residual symptoms and to improve social functioning and quality of life. Among these therapies, psychoeducational therapies showed a significant efficacy on improving drug adherence and on reducing relapses. However, according to the French Health Agency, fewer than 10% of psychiatric structures in France offer registered psychoeducation programs...
May 2017: L'Encéphale
https://www.readbyqxmd.com/read/27637362/attitudes-toward-antipsychotic-medications-as-a-useful-feature-in-exploring-medication-non-adherence-in-schizophrenia
#19
MULTICENTER STUDY
Ludovic Samalin, Ingrid de Chazeron, Olivier Blanc, Lore Brunel, Guillaume Fond, Pierre-Michel Llorca
OBJECTIVE: To investigate the interest in the attitudes toward antipsychotic medication in exploring medication non-adherence. METHODS: Schizophrenic patients (N=120) completed the Beliefs about Medicines Questionnaire and measures of medication adherence, and clinical outcomes. Comparison between four attitudinal groups and logistic regressions were performed. RESULTS: High level of adherence varied significantly between attitudinal groups (Accepting, 70%; Indifferent, 63%; Ambivalent, 50%; Sceptical, 14%; p<0...
December 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27623121/-advocacy-for-the-establishment-of-a-comprehensive-strategy-to-reduce-the-burden-of-schizophrenic-disorders
#20
REVIEW
D Leguay
This article attempts to identify and put into perspective the different approaches that could globally prevent the suffering induced by schizophrenia, from the detection of early psychosis to the impact on individual and family functioning and emotional health. Schizophrenia causes, at the community level, a number of difficult consequences and associated costs, which likely could be reduced if specific strategies, already known and documented internationally, were applied. Two areas not explored in this article: the role of medication and the issue of suicide prevention...
October 2016: L'Encéphale
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