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insight in schizophrenic patients

A El Ammouri, H Kisra
BACKGROUND: Schizophrenia is a chronic, relapsing, mental disorder, and lack of adherence is a common and severe problem in such patients leadingto global and heavy consequences for patients (relapses, hospitalizations, impaired quality of life…), for the family and for society. Improved understanding of the underlying reasons will help to form intervention strategies relevant to the context. OBJECTIVES: We aimed to assess medication adherence among stable patients suffering from schizophrenia and to identify factors associated with non-adherence...
September 20, 2016: L'Encéphale
F Sauvanaud, O Kebir, M Vlasie, V Doste, I Amado, M-O Krebs
INTRODUCTION: In schizophrenic disorders, supportive psychosocial therapies have been used as adjuncts to pharmacotherapy to help alleviate residual symptoms and to improve social functioning and quality of life. Among these therapies, psychoeducational therapies showed a significant efficacy on improving drug adherence and on reducing relapses. However, according to the French Health Agency, fewer than 10% of psychiatric structures in France offer registered psychoeducation programs...
September 19, 2016: L'Encéphale
Ludovic Samalin, Ingrid de Chazeron, Olivier Blanc, Lore Brunel, Guillaume Fond, Pierre-Michel Llorca
OBJECTIVE: To investigate the interest in the attitudes toward antipsychotic medication in exploring medication non-adherence. METHODS: Schizophrenic patients (N=120) completed the Beliefs about Medicines Questionnaire and measures of medication adherence, and clinical outcomes. Comparison between four attitudinal groups and logistic regressions were performed. RESULTS: High level of adherence varied significantly between attitudinal groups (Accepting, 70%; Indifferent, 63%; Ambivalent, 50%; Sceptical, 14%; p<0...
September 13, 2016: Schizophrenia Research
D Leguay
This article attempts to identify and put into perspective the different approaches that could globally prevent the suffering induced by schizophrenia, from the detection of early psychosis to the impact on individual and family functioning and emotional health. Schizophrenia causes, at the community level, a number of difficult consequences and associated costs, which likely could be reduced if specific strategies, already known and documented internationally, were applied. Two areas not explored in this article: the role of medication and the issue of suicide prevention...
September 9, 2016: L'Encéphale
Yunzhe Liu, Dandan Zhang, Yanli Zhao, Shuping Tan, Yuejia Luo
Impaired attentional processing of negative facial expressions is prominent in schizophrenia and has been shown to be associated with patients' social dysfunctions. However, little is known about when and which specific attention deficits influence social functions. Given the dynamic feature of attention, it is necessary to investigate the attention deficits in negative emotional processing unfolding in time. The current study used event-related potentials (ERPs) to investigate the temporal dynamics of attention deficits in emotion perception and their potential relationship with emotional/social impairments in neuroleptic naive schizophrenic patients...
2016: Scientific Reports
Yanling Zhou, Yuping Ning, Robert Rosenheck, Bin Sun, Jie Zhang, Yufen Ou, Hongbo He
Caregiver burden may be especially high in China. However, there has been no empirical study comparing burden experienced by caregivers who live with their patient kin and caregivers live separately from their kin. This study compared caregiver burden in cohabiting and non-cohabiting families and examined characteristics that may account for observed differences ion experienced burden. Patients were evaluated on symptoms, insight, attitudes toward medication before discharge and their prime caregivers were evaluated on family burden shortly after admission...
November 30, 2016: Psychiatry Research
Yanling Zhou, Robert Rosenheck, Somaia Mohamed, Yufen Ou, Yuping Ning, Hongbo He
BACKGROUND: The difference of burden between caregivers of acute patients with schizophrenia and bipolar disorder has not been well studied in China, a culture where family responsibility has a very high value. Our aim is to compare family burden in these two categories diagnosis and to identify predictors of family burden in a large psychiatric hospital in China. METHODS: Two hundred forty-three schizophrenic patients and 200 bipolar patients were enrolled in a cross-sectional study...
2016: BMC Psychiatry
M Villani, V Kovess-Masféty
INTRODUCTION: The progressive shifts in the legal and social contexts, along with major changes in information seeking habits with the development of the Internet, have placed patients' information at the core of medical practice. This has to be applied to the psychiatric fields as well, and to questions about how schizophrenic patients are being told their diagnosis nowadays in France. METHODS: This paper is a national and international literature review about schizophrenia diagnosis disclosure practices, from 1972 to 2014, using French and English languages and various psychology and medical databases...
June 29, 2016: L'Encéphale
Stefan Herning
BACKGROUND: Schizophrenia, in phenomenological psychopathology, is often described as a self disturbance and sometimes as a disturbance of the self-world relation. This study seeks to elaborate on these concepts by examining the significance of the Other in relation to these disturbances. METHOD: Levinas' account of the 'home' will be employed to interpret the phenomenon of 'positive withdrawal'. RESULTS: Positive withdrawal can be conceptualized as a means to domesticate the Other, and schizophrenia can be described as an alteration or absence of the normal mode of being at home in the world...
2016: Psychopathology
Saínza García, Mónica Martínez-Cengotitabengoa, Saioa López-Zurbano, Iñaki Zorrilla, Purificación López, Eduard Vieta, Ana González-Pinto
Antipsychotics are the drugs prescribed to treat psychotic disorders; however, patients often fail to adhere to their treatment, and this has a severe negative effect on prognosis in these kinds of illnesses. Among the wide range of risk factors for treatment nonadherence, this systematic review covers those that are most important from the point of view of clinicians and patients and proposes guidelines for addressing them. Analyzing 38 studies conducted in a total of 51,796 patients, including patients with schizophrenia spectrum disorders and bipolar disorder, we found that younger age, substance abuse, poor insight, cognitive impairments, low level of education, minority ethnicity, poor therapeutic alliance, experience of barriers to care, high intensity of delusional symptoms and suspiciousness, and low socioeconomic status are the main risk factors for medication nonadherence in both types of disorder...
August 2016: Journal of Clinical Psychopharmacology
Hans Rasmussen, Vibe G Frokjaer, Rikke W Hilker, Jacob Madsen, Simon Anhøj, Bob Oranje, Lars H Pinborg, Birte Glenthøj, Gitte M Knudsen
Here we imaged serotonin 2A receptor (5-HT2AR) binding in a very rare population of monozygotic twins discordant for schizophrenia to provide insight into trait and state components in brain 5-HT2AR patterns. In four twin pairs not medicated with drugs that target 5-HT2AR, frontal 5-HT2AR binding was consistently lower (33%) in schizophrenic- relative to their healthy co-twins. Our results strongly imply low frontal 5-HT2AR availability as a state feature of schizophrenia. If replicated, ideally in a larger sample also including dizygotic twin pairs and drug-naïve patients, this finding critically advance our understanding of the complex pathophysiology of schizophrenia...
July 2016: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
Xingqin Zhou, Dong Liu, Rongjun Zhang, Ying Peng, Xiaofeng Qin, Shishi Mao
The aim of study was to investigate the effects of pyrroloquinoline quinone (PQQ) combined with d-serine on the modulation of glycine sites in the brain of rats using social recognition test. Rats were divided into seven groups (n=10) and given repeated intraperitoneal (ip) injections of saline, MK-801 (0.5mg/kg), clozapine (1mg/kg), haloperidol (0.1mg/kg), d-serine (0.8g/kg), PQQ (2.0μg/kg), or d-serine (0.4g/kg) combined with PQQ (1.0μg/kg) for seven days. A social recognition test, including assessment of time-dependent memory impairment, was performed...
July 15, 2016: Behavioural Brain Research
Steffen Schulz, Mathias Bolz, Karl-Jürgen Bär, Andreas Voss
The autonomic nervous system (ANS) dysfunction has been well described in schizophrenia (SZ), a severe mental disorder. Nevertheless, the coupling between the ANS and central brain activity has been not addressed until now in SZ. The interactions between the central nervous system (CNS) and ANS need to be considered as a feedback-feed-forward system that supports flexible and adaptive responses to specific demands. For the first time, to the best of our knowledge, this study investigates central-autonomic couplings (CAC) studying heart rate, blood pressure and electroencephalogram in paranoid schizophrenic patients, comparing them with age-gender-matched healthy subjects (CO)...
May 13, 2016: Philosophical Transactions. Series A, Mathematical, Physical, and Engineering Sciences
Rafael de Assis da Silva, Daniel C Mograbi, Jaqueline Bifano, Cristina M T Santana, Elie Cheniaux
Suicide is a relatively common outcome along the course of bipolar disorder. Studies have shown a positive correlation between ideation or attempts of suicide and higher insight in schizophrenic patients. Nevertheless there are still few studies that evaluate the relationship between suicide and insight in mood disorders. Evaluate the relationship between insight and suicidal ideation or behavior in bipolar depression. A group of 165 bipolar patients were followed up along 1 year. Each patient's mood was assessed in every consultation according to DSM-IV-TR criteria...
March 24, 2016: Psychiatric Quarterly
Q Wang, W Cheng, M Li, H Ren, X Hu, W Deng, X Ma, L Zhao, Y Wang, B Xiang, H-M Wu, P C Sham, J Feng, T Li
BACKGROUND: The genetic influences in human brain structure and function and impaired functional connectivities are the hallmarks of the schizophrenic brain. To explore how common genetic variants affect the connectivities in schizophrenia, we applied genome-wide association studies assaying the abnormal neural connectivities in schizophrenia as quantitative traits. METHOD: We recruited 161 first-onset and treatment-naive patients with schizophrenia and 150 healthy controls...
May 2016: Psychological Medicine
Dario Cannavò, Giuseppe Minutolo, Eliana Battaglia, Eugenio Aguglia
OBJECTIVE: To investigate the correlation between insight and recovery in schizophrenic patients according to criteria for both symptomatic and functional remission. METHODS: Seventy patients affected by paranoid schizophrenia were recruited and treated with olanzapine, risperidone, aripiprazole, haloperidol and ziprasidone; visits were scheduled at baseline, 12 and 36 months. We administered PANSS (Positive and Negative Syndrome Scale), GAF (Global Assessment of Functioning), SF-36 (Short Form 36 Health Survey), PGWBI (Psychological General Well-Being index) and SAI (Schedule for the Assessment of Insight)...
2016: International Journal of Psychiatry in Clinical Practice
Avinash Ramyead, Erich Studerus, Michael Kometer, Ulrike Heitz, Ute Gschwandtner, Peter Fuhr, Anita Riecher-Rössler
OBJECTIVES: In chronic schizophrenic psychoses, oscillatory abnormalities predominantly occur in prefrontal cortical regions and are associated with reduced communication across cortical areas. Nevertheless, it remains unclear whether similar alterations can be observed in patients with a first episode of psychosis (FEP), a state characterised by pathological features occurring in both late prodromal patients and initial phases of frank schizophrenic psychoses. METHODS: We assessed resting-state electroencephalographic data of 31 antipsychotic-naïve FEP patients and 29 healthy controls (HC)...
June 2016: World Journal of Biological Psychiatry
Błażej Misiak, Dorota Frydecka, Jan A Beszłej, Ahmed A Moustafa, Piotr Tybura, Jolanta Kucharska-Mazur, Agnieszka Samochowiec, Przemysław Bieńkowski, Jerzy Samochowiec
We aimed to investigate whether antipsychotics differentially impact insight and whether these effects appear because of improvement in psychopathological manifestation in 132 first-episode schizophrenia patients and 201 acutely relapsed schizophrenic patients, who were followed up for 12 weeks. Olanzapine and risperidone were administered to first-episode schizophrenia patients, whereas acutely relapsed schizophrenic patients were treated with olanzapine, perazine and ziprasidone. The Positive And Negative Syndrome Scale (PANSS) was used to assess psychopathology...
July 2016: International Clinical Psychopharmacology
José L Moreno, Patricia Miranda-Azpiazu, Aintzane García-Bea, Jason Younkin, Meng Cui, Alexey Kozlenkov, Ariel Ben-Ezra, Georgios Voloudakis, Amanda K Fakira, Lia Baki, Yongchao Ge, Anastasios Georgakopoulos, José A Morón, Graeme Milligan, Juan F López-Giménez, Nikolaos K Robakis, Diomedes E Logothetis, J Javier Meana, Javier González-Maeso
Heterotrimeric guanine nucleotide-binding protein (G protein)-coupled receptors (GPCRs) can form multiprotein complexes (heteromers), which can alter the pharmacology and functions of the constituent receptors. Previous findings demonstrated that the Gq/11-coupled serotonin 5-HT2A receptor and the Gi/o-coupled metabotropic glutamate 2 (mGlu2) receptor-GPCRs that are involved in signaling alterations associated with psychosis-assemble into a heteromeric complex in the mammalian brain. In single-cell experiments with various mutant versions of the mGlu2 receptor, we showed that stimulation of cells expressing mGlu2-5-HT2A heteromers with an mGlu2 agonist led to activation of Gq/11 proteins by the 5-HT2A receptors...
January 12, 2016: Science Signaling
Saeed Shoja Shafti, Sasan Akbari
OBJECTIVES: Negative symptoms are a significant barrier to successful functional outcome and recovery in individuals with schizophrenia, and their management is not easy. Prior tryouts with antidepressants and some cognitive enhancers were not really encouraging, and experiments with modafinil had mixed and indecisive results. The objective of the present study was to assess modafinil's efficacy on subjective and objective aspects of negative symptoms of schizophrenia. METHODS: This study was an 8-week randomized, placebo-controlled trial of modafinil, as an adjective to haloperidol, in treatment of 50 schizophrenic patients...
February 2016: Journal of Clinical Psychopharmacology
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