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https://www.readbyqxmd.com/read/29768672/catheter-ablation-for-atrial-fibrillation-on-uninterrupted-direct-oral-anticoagulants-a-safe-approach
#1
V Sawhney, M Shaukat, E Volkova, N Jones, R Providencia, S Honarbakhsh, G Dhillon, A Chow, M Lowe, P Lambiase, M Dhinoja, S Sporton, M J Earley, R J Schilling, R J Hunter
BACKGROUND: Current consensus guidelines suggest DOACs are interrupted peri-procedurally for catheter ablation (CA) of AF. However, this may predispose patients to thromboembolic complications. This study investigates the safety of CA for AF on uninterrupted DOACs compared to uninterrupted warfarin. METHODS: Single centre, retrospective study of consecutive patients undergoing CA for AF. All patients were heparinised prior to trans-septal puncture with a target activated clotting time (ACT) of 300-350 seconds...
May 16, 2018: Pacing and Clinical Electrophysiology: PACE
https://www.readbyqxmd.com/read/29761300/natural-selection-and-drift-as-individual-level-causes-of-evolution
#2
Pierrick Bourrat
In this paper I critically evaluate Reisman and Forber's (Philos Sci 72(5):1113-1123, 2005) arguments that drift and natural selection are population-level causes of evolution based on what they call the manipulation condition. Although I agree that this condition is an important step for identifying causes for evolutionary change, it is insufficient. Following Woodward, I argue that the invariance of a relationship is another crucial parameter to take into consideration for causal explanations. Starting from Reisman and Forber's example on drift and after having briefly presented the criterion of invariance, I show that once both the manipulation condition and the criterion of invariance are taken into account, drift, in this example, should better be understood as an individual-level rather than a population-level cause...
May 14, 2018: Acta Biotheoretica
https://www.readbyqxmd.com/read/29739989/haplotypic-polymorphisms-and-mutation-rate-estimates-of-22-y-chromosome-strs-in-the-northern-chinese-han-father-son-pairs
#3
Yaran Yang, Weini Wang, Feng Cheng, Man Chen, Tong Chen, Jing Zhao, Chong Chen, Yan Shi, Chen Li, Chuguang Chen, Yacheng Liu, Jiangwei Yan
Y chromosome Short tandem repeats (Y-STRs) analysis has been widely used in forensic identification, kinship testing, and population evolution. An accurate understanding of haplotype and mutation rate will benefit these applications. In this work, we analyzed 1123 male samples from Northern Chinese Han population which including 578 DNA-confirmed father-son pairs at 22 Y-STRs loci. A total of 537 haplotypes were observed and the overall haplotype diversity was calculated as 1.0000 ± 0.0001. Except that only two haplotypes were observed twice, all the rest of the 535 were unique...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29739745/left-ventricular-mechanical-unloading-by-total-support-of-impella-in-myocardial-infarction-reduces-infarct-size-preserves-left-ventricular-function-and-prevents-subsequent-heart-failure-in-dogs
#4
Keita Saku, Takamori Kakino, Takahiro Arimura, Genya Sunagawa, Takuya Nishikawa, Takafumi Sakamoto, Takuya Kishi, Hiroyuki Tsutsui, Kenji Sunagawa
BACKGROUND: Acute myocardial infarction remains a leading cause of chronic heart failure. Excessive myocardial oxygen demand relative to supply is the fundamental mechanism of myocardial infarction. We thus hypothesized that left ventricular (LV) mechanical unloading by the total support of transvascular LV assist device Impella could minimize oxygen demand, thereby reducing infarct size and preventing subsequent heart failure. METHODS AND RESULTS: In 20 dogs, we ligated the left anterior descending coronary artery for 180 minutes and then reperfused...
May 2018: Circulation. Heart Failure
https://www.readbyqxmd.com/read/29739647/estimation-of-the-blood-pressure-response-with-exercise-stress-testing
#5
Benjamin T Fitzgerald, Emma L Ballard, Gregory M Scalia
BACKGROUND: The blood pressure response to exercise has been described as a significant increase in systolic BP (sBP) with a smaller change in diastolic BP (dBP). This has been documented in small numbers, in healthy young men or in ethnic populations. This study examines these changes in low to intermediate risk of myocardial ischaemia in men and women over a wide age range. METHODS: Consecutive patients having stress echocardiography were analysed. Ischaemic tests were excluded...
April 20, 2018: Heart, Lung & Circulation
https://www.readbyqxmd.com/read/29732007/dwi-histology-a-possible-means-of-determining-degree-of-liver-fibrosis
#6
Niklas Verloh, Kirsten Utpatel, Michael Haimerl, Florian Zeman, Claudia Fellner, Marc Dahlke, Philipp Renner, Timo Seyfried, Martina Müller, Christian Stroszczynski, Matthias Evert, Philipp Wiggermann
Objectives: The aim of this study was to determine the diagnostic value of diffusion-weighted MRI of the liver at 3T to classify liver fibrosis/cirrhosis. Methods: 62 patients who underwent both histopathological examination and diffusion-weighted imaging of the liver via 3T MRI within a period of 3 months were included in the study. The Ishak score (1-6) was used to determine the degree of fibrosis: No liver fibrosis (NLF; Ishak 0, n = 16), mild liver fibrosis (MLF; Ishak 1-2, n = 23), advanced liver fibrosis (ALF; Ishak 3-5, n = 12), and liver cirrhosis (LC; Ishak 6, n = 11)...
April 13, 2018: Oncotarget
https://www.readbyqxmd.com/read/29716867/quantitative-determination-of-mogroside-v-in-rat-plasma-by-lc-ms-ms-and-its-application-to-a-pharmacokinetic-study
#7
Huiyu Yan, Lina Tao, Xiaoyu Qu, Liting Zhou, Sixi Zhang
Mogroside V is the most abundant (approximately 0.50%) cucurbitane-type triterpene glycoside in Siraitia grosvenorii and exhibits significant antitussive, expectorant, anti-carcinogenic, and anti-inflammatory effects. A sensitive, robust and selective liquid chromatography tandem with mass spectrometry (LC-MS/MS) was developed and validated for the determination and pharmacokinetic investigation of mogroside V in rat plasma. Samples were prepared through an one-step deproteinization procedure with 250 µL of methanol to a 75-µL plasma sample...
May 2018: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29716539/use-of-dietary-supplements-by-pregnant-women-in-colombia
#8
Robinson Ramírez-Vélez, Jorge Enrique Correa-Bautista, Héctor Reynaldo Triana-Reina, Emilio González-Jiménez, Jacqueline Schmidt-RioValle, Katherine González-Ruíz
BACKGROUND: During pregnancy, the need for certain nutrients increases. This study assessed the prevalence and socio-demographic factors associated with dietary supplement use in a representative sample of pregnant women in Colombia. METHOD: Data for this study were obtained from a cross-sectional, nationally representative survey (ENSIN, 2010). A total of 1856 pregnant women, 13-49 years of age, were recruited. The use of prenatal dietary supplements (Vitamins A, C or E) was treated as a binary outcome (used at some time or never sued during pregnancy when prescribed by a doctor) in multinomial analyses...
May 2, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29703920/prevalent-metabolic-derangement-and-severe-thrombocytopenia-in-abo-incompatible-liver-recipients-with-pre-transplant-plasma-exchange
#9
Hye-Mee Kwon, In-Gu Jun, JungBok Lee, Young-Jin Moon, Kyeo-Woon Jung, Hye-Won Jeong, Yong-Seok Park, Jun-Gol Song, Gyu-Sam Hwang
Desensitisation with therapeutic plasma exchange (TPE) is essential for ABO-incompatible (ABO-I) liver transplants (LTs). However, excessive citrate load and coagulation disturbances after TPE have been poorly studied, in particular in cirrhotic patients with hypocapnic alkalosis, metabolic compensation and electrolyte imbalances. We retrospectively evaluated 1123 consecutive LT recipients (923 ABO-compatible [ABO-C], 200 ABO-I) from November 2008 to May 2015. TPE was generally performed a day before LT and blood sampling was performed before anaesthesia induction...
April 27, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29700680/can-tissue-biomarkers-reliably-predict-the-biological-behavior-of-craniopharyngiomas-a-comprehensive-overview
#10
REVIEW
Ruth Prieto, José M Pascual
BACKGROUND: The growing interest in the molecular and genetic alterations of craniopharyngiomas (CPs) is embodied in recent studies revealing insights into the CP tumorigenesis and identifying novel molecular pathways amenable of targeted therapies. The actual impact of this new information, however, remains inconclusive. METHODS: We present a comprehensive review of the accumulated knowledge on molecular biology of CPs and a critical analysis on the strengths and weaknesses of the studies focused on CP molecular/genetic alterations published to date...
April 26, 2018: Pituitary
https://www.readbyqxmd.com/read/29695512/individual-participant-data-analysis-of-two-trials-on-aldosterone-blockade-in-myocardial-infarction
#11
Farzin Beygui, Eric Van Belle, Patrick Ecollan, Jacques Machecourt, Christian W Hamm, Estaeban Lopez De Sa, Marcus Flather, Freek W A Verheugt, Eric Vicaut, Faiez Zannad, Bertram Pitt, Gilles Montalescot
BACKGROUND: Two recent randomised trials studied the benefit of mineralocorticoid receptor antagonists (MRAs) in ST-segment elevation myocardial infarction (STEMI) irrespective or in absence of heart failure. The studies were both undersized to assess hard clinical endpoints. A pooled analysis was preplanned by the steering committees. METHODS: We conducted a prespecified meta-analysis of patient-level data of patients with STEMI recruited in two multicentre superiority trials, randomised within 72 hours after symptom onset...
April 25, 2018: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/29680936/hiv-risk-and-protective-factors-in-the-context-of-alcohol-and-substance-use-during-pride
#12
Paul A Shuper, Duncan J MacLachlan, Narges Joharchi, Tim H Guimond, John Maxwell, Barry D Adam
This investigation sought to identify HIV-risk and -protective factors among men-who-have-sex-with-men (MSM) who engaged in anal sex following alcohol or substance use during an international Pride Festival. MSM attending World Pride were surveyed regarding (1) alcohol, substance use, and sex during the past 24 h; and (2) HIV-risk and -protective factors. Valid data were provided by 1123 MSM. Anal sex was reported by 195 MSM, among whom the majority (n = 105) consumed alcohol or substances prior to sex...
April 21, 2018: AIDS and Behavior
https://www.readbyqxmd.com/read/29620033/the-4-4-thermocyclization-of-9-anthraldehyde-synthesis-crystal-structure-experimental-and-theoretical-uv-spectra-natural-bonding-orbital-analysis-and-prediction-of-third-order-nonlinear-optical-properties
#13
Seyed Amir Zarei, Keivan Akhtari, Mohammad Piltan, Shaaban M Kamel, Joel T Mague
The dimer of 9-anthraldehyde, namely heptacyclo[8.6.6.62,9 .03,8 .011,16 .017,22 .023,28 ]octacosa-3,5,7,11,13,15,17(22),18,20,23(28),24,26-dodecaene-1,9-carbaldehyde, C30 H20 O2 , has been synthesized by refluxing an ethanol solution in the presence of M(ClO4 )2 and 1,3-diaminopropan-2-ol (M = Co2+ or Cu2+ ). Its structure has been determined by single-crystal X-ray diffraction, showing it to be a new polymorph, referred to as polymorph II, in the monoclinic space group P21 /n. It is compared with the previously reported triclinic modification [Ehrenberg (1968)...
April 1, 2018: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/29617375/gender-transformative-bandebereho-couples-intervention-to-promote-male-engagement-in-reproductive-and-maternal-health-and-violence-prevention-in-rwanda-findings-from-a-randomized-controlled-trial
#14
Kate Doyle, Ruti G Levtov, Gary Barker, Gautam G Bastian, Jeffrey B Bingenheimer, Shamsi Kazimbaya, Anicet Nzabonimpa, Julie Pulerwitz, Felix Sayinzoga, Vandana Sharma, Dominick Shattuck
BACKGROUND: Rigorous evidence of the effectiveness of male engagement interventions, particularly on how these interventions impact relationship power dynamics and women's decision-making, remains limited. This study assessed the impact of the Bandebereho gender-transformative couples' intervention on impact on multiple behavioral and health-related outcomes influenced by gender norms and power relations. METHODS: We conducted a multi-site randomised controlled trial in four Rwandan districts with expectant/current fathers and their partners, who were randomised to the intervention (n = 575 couples) or control group (n = 624 couples)...
2018: PloS One
https://www.readbyqxmd.com/read/29600910/retrospective-single-surgeon-study-of-1123-consecutive-cases-of-anterior-cervical-discectomy-and-fusion-a-comparison-of-clinical-outcome-parameters-complication-rates-and-costs-between-outpatient-and-inpatient-surgery-groups-with-a-literature-review
#15
Jack Mullins, Mirza Pojskić, Frederick A Boop, Kenan I Arnautović
OBJECTIVE Outpatient anterior cervical discectomy and fusion (ACDF) is becoming more common and has been reported to offer advantages over inpatient procedures, including reducing nosocomial infections and costs, as well as improving patient satisfaction. The goal of this retrospective study was to evaluate and compare outcome parameters, complication rates, and costs between inpatient and outpatient ACDF cases performed by 1 surgeon at a single institution. METHODS In a retrospective study, the records of all patients who had undergone first-time ACDF performed by a single surgeon in the period from June 1, 2003, to January 31, 2016, were reviewed...
March 30, 2018: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/29570599/increased-leg-bone-mineral-density-and-content-during-the-initial-years-of-college-sport
#16
John J Scerpella, Bjoern Buehring, Scott J Hetzel, Bryan C Heiderscheit
Scerpella, JJ, Buehring, B, Hetzel, SJ, and Heiderscheit, BC. Increased leg bone mineral density and content during the initial years of college sport. J Strength Cond Res 32(4): 1123-1130, 2018-Bone mineral density (BMD) and bone mineral content (BMC) data are useful parameters for evaluating how training practices promote bone health. We used dual-energy X-ray absorptiometry (DXA) to longitudinally assess sport-specific growth in leg and total body BMD/BMC over the initial 2 years of collegiate training. Eighty-five Division 1 collegiate basketball, hockey, and soccer athletes (50 males and 35 females; age 19...
April 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29555117/assessing-fugitive-emissions-of-ch-4-from-high-pressure-gas-pipelines-in-the-uk
#17
Ian M Boothroyd, Sam Almond, Fred Worrall, Rosemary K Davies, Richard J Davies
Natural gas pipelines are an important source of fugitive methane emissions in lifecycle greenhouse gas assessments but limited monitoring has taken place of UK pipelines to quantify fugitive emissions. This study investigated methane emissions from the UK high-pressure pipeline system (National Transmission System - NTS) for natural gas pipelines. Mobile surveys of CH4 emissions were conducted across four areas in the UK, with routes bisecting high-pressure pipelines (with a maximum operating pressure of 85bar) and separate control routes away from the pipelines...
August 1, 2018: Science of the Total Environment
https://www.readbyqxmd.com/read/29529908/withdrawal-plews-and-laursen-2017
#18
(no author information available yet)
We, the Editors and Publishers of the International Journal of Sports Physiology and Performance, have withdrawn the following article in whole: Plews, DJ, Laursen, PB. Training intensity distribution over a four-year cycle in Olympic champion rowers: different roads lead to Rio [version of record published online ahead of print September 27, 2017]. Int J Sports Physiol Perform. doi: 10.1123/ijspp.2017-0343 . The Editorial Office was contacted with the request to withdraw this article informing the Editor-in-Chief that the data in this article were not permissible to use due to undisclosed contractual obligations...
March 1, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29517405/erratum-berryman-et-al-2018
#19
(no author information available yet)
In the article by Berryman N, Mujika I, Arvisais D, Roubeix M, Binet C, Bosquet L. Strength training for middle- and long-distance performance: a meta-analysis. Int J Sports Physiol Perform. 2018;13(1):57-63. doi: 10.1123/ijspp.2017-0032 , there were errors in an author's name and with 2 author affiliations: (1) Iñigo Mujika was incorrectly spelled as Inigo Mujika, (2) Mujika's second affiliation (School of Kinesiology, Universidad Finis Terrae, Santiago, Chile) was absent, and (c) University of Poitiers was incorrectly spelled as University or Poitiers...
March 1, 2018: International Journal of Sports Physiology and Performance
https://www.readbyqxmd.com/read/29494739/treatment-trends-and-outcomes-for-patients-with-lymph-node-positive-cancer-of-the-penis
#20
Shreyas S Joshi, Elizabeth Handorf, David Strauss, Andres F Correa, Alexander Kutikov, David Y T Chen, Rosalia Viterbo, Richard E Greenberg, Robert G Uzzo, Marc C Smaldone, Daniel M Geynisman
Importance: Penile cancer is an uncommon disease with minimal level I evidence to guide therapy. The National Comprehensive Cancer Network (NCCN) guidelines advocate a lymph node dissection (LND) or radiotherapy with consideration of perioperative chemotherapy for all patients with lymph node-positive (LN+) penile cancer without metastasis. Objectives: To determine temporal trends in use of chemotherapy for patients with LN+ penile cancer without metastasis and to evaluate outcomes between those who did or did not receive LND, chemotherapy, and radiotherapy...
March 1, 2018: JAMA Oncology
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