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https://www.readbyqxmd.com/read/28881680/identification-of-dysregulated-long-non-coding-rnas-micrornas-mrnas-in-tnm-i-stage-lung-adenocarcinoma
#1
Ziqiang Tian, Shiwang Wen, Yuefeng Zhang, Xinqiang Shi, Yonggang Zhu, Yanzhao Xu, Huilai Lv, Guiying Wang
Lung adenocarcinoma (LUAD) is the primary subtype in lung cancer, which is the leading cause of cancer-related death worldwide. This study aimed to investigate the aberrant expression profiling of long non-coding RNA (lncRNA) in TNM I stage (stage I) LUAD. The lncRNA/mRNA/miRNA expression profiling of stage I LUAD and adjacent non-tumor tissues from 4 patients were measured by RNA-sequencing. Total of 175 differentially expressed lncRNAs (DELs), 1321 differentially expressed mRNAs (DEMs) and 94 differentially expressed microRNAs (DEMIs) were identified in stage I LUAD...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28875345/modified-hyperbranched-polyglycerol-as-dispersant-for-size-control-and-stabilization-of-gold-nanoparticles-in-hydrocarbons
#2
Yanyu Shen, Guijin He, Yongsheng Guo, Hujun Xie, Wenjun Fang
Hyperbranched polyglycerol (HPG) is modified with dodecanethiol (DS) via the "thiol-ene" click reaction to obtain an amphiphilic product DSHPG. The molecular structures of DSHPG samples are characterized by NMR, FTIR, and GPC, and the thermal behaviors are characterized by DSC and TGA. Gold nanoparticles (Au NPs) are prepared with DSHPG as the stabilizer and surface-modification reagent. The size of Au NPs can be tuned by changing the molecular weight of HPG. It is observed that the HPG molecular weights of 1123, 3826, and 55,075 lead to the NP diameters of 4...
September 6, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28836882/erratum-lin-and-karduna-2017
#3
Casey Gentis
Come from the Glenohumeral Joint, "in J Appl Biomech. 33(1):32-38, https://doi.org/10.1123/jab.2016-0034 , Figure 3c was a duplicate of Figure 3b and was therefore incorrect. The online version of this article has been corrected; we apologize for this error.
August 24, 2017: Journal of Applied Biomechanics
https://www.readbyqxmd.com/read/28798540/growth-differentiation-factor-15-may-predict-mortality-of-peripheral-and-coronary-artery-diseases-and-correlate-with-their-risk-factors
#4
Lung-An Hsu, Semon Wu, Jyh-Ming Jimmy Juang, Fu-Tien Chiang, Ming-Sheng Teng, Jeng-Feng Lin, Hsuan-Li Huang, Yu-Lin Ko
Plasma GDF15 concentrations were measured in 612 Taiwanese individuals without overt systemic disease. Clinical parameters, GDF15 genetic variants, and 22 biomarker levels were analyzed. We further enrolled 86 patients with PAD and 481 patients with CAD, who received endovascular intervention and coronary angiography, respectively, to examine the role of GDF15 level in predicting all-cause mortality. Significant associations were found between GDF15 genotypes/haplotypes and GDF15 levels. The circulating GDF15 level was positively associated with age, smoking, hypertension, and diabetes mellitus as well as circulating levels of lipocalin 2 and various biomarkers of inflammation and oxidative stress...
2017: Mediators of Inflammation
https://www.readbyqxmd.com/read/28678848/mental-health-literacy-survey-of-non-mental-health-professionals-in-six-general-hospitals-in-hunan-province-of-china
#5
Qiuxia Wu, Xiaoyang Luo, Shubao Chen, Chang Qi, Jiang Long, Yifan Xiong, Yanhui Liao, Tieqiao Liu
BACKGROUND: Mental illness has brought great economic burden related to misdiagnosis by non-mental health professionals in general hospitals. The aim of this study was to explore non-mental health professionals' conceptions related to the identification of mental illness and perceived treatments, first aid and prognosis. METHODS: In 2014-2015, we presented 1123 non-mental health professionals from six general hospitals in Hunan Province with one of three vignettes describing a person with schizophrenia, depression, or generalized anxiety disorder...
2017: PloS One
https://www.readbyqxmd.com/read/28668885/interactive-analysis-of-tx-1123-with-cyclo-oxygenase-design-of-cox2-selective-tx-analogs
#6
Kazuto Ohkura, Yohei Tatematsu, Yuki Kawaguchi, Yoshihiro Uto, Hitoshi Hori
BACKGROUND: To date, two cyclo-oxygenase (COX) isoforms, COX1 and COX2, have been identified. In the present study, the COX-inhibitory activities of TX-1123 derivatives with the 2-hydroxyarylidene-4-cyclopentene-1,3-dione structure were examined, and the binding profiles of TX-1123 to COXs were analyzed using docking simulations. MATERIALS AND METHODS: X-Ray data on COX1 [protein data bank (PDB) ID=1PGG] and COX2 (PDB ID=3LN1) were used for molecular interactive simulations...
July 2017: Anticancer Research
https://www.readbyqxmd.com/read/28654912/identification-of-dysregulated-long-non-coding-rnas-micrornas-mrnas-in-tnm-i-stage-lung-adenocarcinoma
#7
Ziqiang Tian, Shiwang Wen, Yuefeng Zhang, Xinqiang Shi, Yonggang Zhu, Yanzhao Xu, Huilai Lv, Guiying Wang
Lung adenocarcinoma (LUAD) is the primary subtype in lung cancer, which is the leading cause of cancer-related death worldwide. This study aimed to investigate the aberrant expression profiling of long non-coding RNA (lncRNA) in TNM I stage (stage I) LUAD. The lncRNA/mRNA/miRNA expression profiling of stage I LUAD and adjacent non-tumor tissues from 4 patients were measured by RNA-sequencing. Total of 175 differentially expressed lncRNAs (DELs), 1321 differentially expressed mRNAs (DEMs) and 94 differentially expressed microRNAs (DEMIs) were identified in stage I LUAD...
June 16, 2017: Oncotarget
https://www.readbyqxmd.com/read/28653143/impact-of-time-since-last-childbirth-on-survival-of-women-with-premenopausal-and-postmenopausal-breast-cancers
#8
Nanthini Balakrishnan, Soo-Hwang Teo, Siamala Sinnadurai, Nanthini Thevi Bhoo Pathy, Mee-Hoong See, Nur Aishah Taib, Cheng-Har Yip, Nirmala Bhoo Pathy
BACKGROUND: Reproductive factors are associated with risk of breast cancer, but the association with breast cancer survival is less well known. Previous studies have reported conflicting results on the association between time since last childbirth and breast cancer survival. We determined the association between time since last childbirth (LCB) and survival of women with premenopausal and postmenopausal breast cancers in Malaysia. METHOD: A historical cohort of 986 premenopausal, and 1123 postmenopausal, parous breast cancer patients diagnosed from 2001 to 2012 in University Malaya Medical Centre were included in the analyses...
June 26, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28621562/association-between-alcohol-consumption-trajectories-and-clinical-profiles-among-women-and-men-living-with-hiv
#9
Natalie E Kelso-Chichetto, Michael Plankey, Alison G Abraham, Nicole Ennis, Xinguang Chen, Robert Bolan, Robert L Cook
BACKGROUND: Alcohol use is common among persons living with HIV (PLWH). It is unclear how alcohol consumption changes over time and if these changes are associated with clinical profiles. OBJECTIVE: We aimed to describe the association between longitudinal patterns of alcohol consumption and the clinical profiles of PLWH. METHODS: Data from the Women's Interagency HIV Study (n = 1123 women) and Multicenter AIDS Cohort Study (n = 597 men) from 2004 to 2013 were utilized...
June 16, 2017: American Journal of Drug and Alcohol Abuse
https://www.readbyqxmd.com/read/28601738/evaluation-of-a-women-group-led-health-communication-program-in-haryana-india
#10
Manmeet Kaur, Nidhi Jaswal, Anil Kumar Saddi
BACKGROUND: Sakshar Mahila Smooh (SMS) program was launched in rural areas of Haryana in India during 2008. A total of 6788 SMSs, each having 5-10 literate women, were equipped to enhance health communication. We carried out process evaluation of this program as an external agency. METHODOLOGY: After a review of program documents, a random sample survey of Auxiliary Nurse Midwives (ANMs), SMS members, and village women was conducted. Out of four divisions of the state, one was randomly chosen, which had five districts...
June 4, 2017: Evaluation and Program Planning
https://www.readbyqxmd.com/read/28566264/understanding-environmental-and-contextual-influences-of-physical-activity-during-first-year-university-the-feasibility-of-using-ecological-momentary-assessment-in-the-movingu-study
#11
Chloe Bedard, Sara King-Dowling, Madeline McDonald, Genevieve Dunton, John Cairney, Matthew Kwan
BACKGROUND: It is well established that drastic declines in physical activity (PA) occur during young adults' transition into university; however, our understanding of contextual and environmental factors as it relates to young adults' PA is limited. OBJECTIVE: The purpose of our study was to examine the feasibility of using wrist-worn accelerometers and the use of ecological momentary assessment (EMA) to assess the context and momentary correlates of PA on multiple occasions each day during first-year university...
May 31, 2017: JMIR Public Health and Surveillance
https://www.readbyqxmd.com/read/28556765/erratum-bardid-et-al-2016
#12
(no author information available yet)
In the article by Bardid F., Huyben F., Deconinck F.J.A., De Martelaer K., Seghers J., & Lenoir M., "Convergent and Divergent Validity Between the KTK and MOT 4-6 Motor Tests in Early Childhood, " in Adapted Pyhsical Activity Quarterly, 33(1), the wrong DOI was printed. The DOI for this article is http://dx.doi.org/10.1123/APAQ.2014-0228. The online version has been corrected.
April 2017: Adapted Physical Activity Quarterly: APAQ
https://www.readbyqxmd.com/read/28539661/the-pb2-mutation-with-lysine-at-627-enhances-the-pathogenicity-of-avian-influenza-h7n9-virus-which-belongs-to-a-non-zoonotic-lineage
#13
Weixuan Li, Horace Hok Yeung Lee, Run Feng Li, Huachen Maria Zhu, Guan Yi, Joseph Sriyal Malik Peiris, Zi Feng Yang, Chris Ka Pun Mok
A novel avian-origin influenza A (H7N9) virus emerged in China in 2013 and has caused zoonotic disease in over 1123 persons with an overall mortality around 30%. Amino acid changes at the residues 591, 627 and 701 of polymerase basic protein 2 (PB2) have been found frequently in the human H7N9 isolates but not in viruses isolated from avian species. We have recently identified a cluster of H7N9 viruses in ducks which circulated in China prior to the first recognition of zoonotic disease in 2013. These duck viruses have genetic background distinct from the zoonotic H7N9 lineage...
May 24, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28537384/cysteine-functionalized-metal-organic-framework-facile-synthesis-and-high-efficient-enrichment-of-n-linked-glycopeptides-in-cell-lysate
#14
Wen Ma, Linnan Xu, Xianjiang Li, Sensen Shen, Mei Wu, Yu Bai, Huwei Liu
Cysteine-functionalized metal-organic framework (MOF) was synthesized via a common and facile two-step method of in situ loading of Au nanoparticles on amino-derived MOF followed by l-cysteine (Cys) immobilization. Owing to the large specific surface area and ultrahigh hydrophilicity of this nanocomposite, excellent performance was observed in the enrichment of N-linked glycopeptides in both model glycoprotein and HeLa cell lysate. By using this nanocomposite, 16 and 31 glycopeptides were efficiently extracted from digest of horseradish peroxidase (HRP) and human serum immunoglobulin G (IgG), respectively...
June 1, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28535726/the-effects-of-arousal-reappraisal-on-stress-responses-performance-and-attention
#15
Nadine Sammy, Paul A Anstiss, Lee J Moore, Paul Freeman, Mark R Wilson, Samuel J Vine
BACKGROUND AND OBJECTIVES: This study examined the effects of arousal reappraisal on cardiovascular responses, demand and resource evaluations, self-confidence, performance and attention under pressurized conditions. A recent study by Moore et al. [2015. Reappraising threat: How to optimize performance under pressure. Journal of Sport and Exercise Psychology, 37(3), 339-343. doi: 10.1123/jsep.2014-0186 ] suggested that arousal reappraisal is beneficial to the promotion of challenge states and leads to improvements in single-trial performance...
May 23, 2017: Anxiety, Stress, and Coping
https://www.readbyqxmd.com/read/28535098/ball-contact-injuries-in-11-national-collegiate-athletic-association-sports-the-injury-surveillance-program-2009-2010-through-2014-2015
#16
Melissa A Fraser, Dustin R Grooms, Kevin M Guskiewicz, Zachary Y Kerr
CONTEXT:   Surveillance data regarding injuries caused by ball contact in collegiate athletes have not been well examined and are mostly limited to discussions of concussions and catastrophic injuries. OBJECTIVE:   To describe the epidemiology of ball-contact injuries in 11 National Collegiate Athletic Association (NCAA) sports during the 2009-2010 through 2014-2015 academic years. DESIGN:   Descriptive epidemiology study. SETTING:   Convenience sample of NCAA programs in 11 sports (men's football, women's field hockey, women's volleyball, men's baseball, women's softball, men's and women's basketball, men's and women's lacrosse, and men's and women's soccer) during the 2009-2010 through 2014-2015 academic years...
July 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28520588/evaluation-of-the-quality-of-semen-and-sexual-function-in-men-with-inflammatory-bowel-disease
#17
Paz Valer, Alicia Algaba, Daniel Santos, Manuel E Fuentes, Elva Nieto, Javier P Gisbert, Pilar López, Elvira Quintanilla, Francisco J García-Alonso, Iván Guerra, Álvaro Páez, Fernando Bermejo
BACKGROUND: Data on fertility rates and medication safety in men with inflammatory bowel disease (IBD) are limited. The aim of this study was to evaluate whether there is a seminal alteration in patients with IBD and, if so, to evaluate the mechanisms that may play a role according to what has been described in the literature. Its secondary aim was to evaluate the impact on male sexual function of IBD. METHODS: Multicenter, cross-sectional, case series study comparing men with IBD and control subjects...
July 2017: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/28497099/acetabular-fractures-in-the-senior-population-epidemiology-mortality-and-treatments
#18
Reza Firoozabadi, William W Cross, James C Krieg, Milton L Chip Routt
BACKGROUND: Management of acetabular fractures in the senior population can be one of the most challenging injuries to manage. Furthermore, treating surgeons have a paucity of information to guide the treatment in this patient population. THE PURPOSE OF THIS STUDY WAS TO DETERMINE: (1) demographic and epidemiologic data, (2) mortality rates for nonoperative compared to operative management at different time points, (3) common fracture configurations, and (4) fracture fixation strategies in senior patients treated with acetabular fractures...
March 2017: Archives of Bone and Joint Surgery
https://www.readbyqxmd.com/read/28485290/wp%C3%A5-yw-wybranych-czynnik%C3%A3-w-%C3%A5-rodowiskowych-na-maksymalny-przep%C3%A5-yw-nosowy-wdechowy-cz%C3%A4-%C3%A5-%C3%A4-projektu-ecap-epidemiologia-chor%C3%A3-b-alergicznych-w-polsce
#19
Edyta Krzych-Fałta, Konrad Furmańczyk, Barbara Piekarska, Adam Sybilski, Bolesław Samoliński
Celem niniejszej pracy była próba określenia wpływu wybranych czynników/parametrów na wynik maksymalnego przepływu nosowego wdechowego (PNIF, ang. peak nasal inspiratory flow) w badanej populacji polskiej projektu Epidemiologia Chorób Alergicznych w Polsce (ECAP). Materiał/metody: Badaną populację stanowiła grupa dzieci w wieku 6-7 lat (n=1123), młodzieży w wieku 13-14 lat (n=1136) oraz dorosłych (n=1876) zamieszkałych w siedmiu dużych polskich miastach. W badaniu posłużono się pomiarem maksymalnego przepływu nosowego wdechowego (PNIF)...
February 28, 2017: Otolaryngologia Polska
https://www.readbyqxmd.com/read/28444518/video-based-approach-to-engaging-parents-into-a-preventive-parenting-intervention-for-divorcing-families-results-of-a-randomized-controlled-trial
#20
Emily B Winslow, Sanford Braver, Robert Cialdini, Irwin Sandler, Jennifer Betkowski, Jenn-Yun Tein, Liza Hita, Mona Bapat, Lorey Wheeler, Monique Lopez
The public health impact of evidence-based, preventive parenting interventions has been severely constrained by low rates of participation when interventions are delivered under natural conditions. It is critical that prevention scientists develop effective and feasible parent engagement methods. This study tested video-based methods for engaging parents into an evidence-based program for divorcing parents. Three alternative versions of a video were created to test the incremental effectiveness of different theory-based engagement strategies based on social influence and health behavior models...
April 25, 2017: Prevention Science: the Official Journal of the Society for Prevention Research
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