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https://www.readbyqxmd.com/read/29323547/accuracy-of-ct-attenuation-measurement-for-differentiating-treated-osteoblastic-metastases-from-enostoses
#1
Stacey M Elangovan, Ronnie Sebro
OBJECTIVE: The objective of our study was to assess whether the maximum and mean CT attenuations are accurate for differentiating between enostoses and treated sclerotic metastases. MATERIALS AND METHODS: We retrospectively reviewed CT studies of 165 patients (167 lesions) that included 49 patients with 49 benign lesions, 69 patients with 71 sclerotic treated lesions, and 47 patients with 47 untreated lesions, and calculated the mean and maximum CT attenuations of each lesion...
January 11, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29296958/characterizing-the-o-glycosylation-landscape-of-human-plasma-platelets-and-endothelial-cells
#2
Sarah L King, Hiren J Joshi, Katrine T Schjoldager, Adnan Halim, Thomas D Madsen, Morten H Dziegiel, Anders Woetmann, Sergey Y Vakhrushev, Hans H Wandall
The hemostatic system comprises platelet aggregation, coagulation, and fibrinolysis, and is critical to the maintenance of vascular integrity. Multiple studies indicate that glycans play important roles in the hemostatic system; however, most investigations have focused on N-glycans because of the complexity of O-glycan analysis. Here we performed the first systematic analysis of native-O-glycosylation using lectin affinity chromatography coupled to liquid chromatography mass spectrometry (LC-MS)/MS to determine the precise location of O-glycans in human plasma, platelets, and endothelial cells, which coordinately regulate hemostasis...
February 28, 2017: Blood Advances
https://www.readbyqxmd.com/read/29219653/characteristics-and-outcome-of-intractable-vasculitis-syndrome-in-children-nation-wide-survey-in-japan
#3
Naoko Nakano, Masaaki Mori, Hiroaki Umebayashi, Naomi Iwata, Norimoto Kobayashi, Kenji Masunaga, Tomoyuki Imagawa, Takuji Murata, Noriko Kinjo, Kazushige Nagai, Mari Miyoshi, Syuji Takei, Shumpei Yokota, Eiichi Ishii
OBJECTIVE: Primary systemic vasculitis (PSV) is a rare disorder in children and difficult to distinguish from other diseases. However, appropriate diagnosis and prompt treatment will affect on the morbidity and mortality of intractable PSV. In this study, we conducted a nationwide survey in Japan, to clarify epidemiology and clinical outcome of PSV. METHODS: We had sent survey questionnaires to most of the Japanese institutions that employed pediatricians, requesting the number of patients with refractory PSV who were diagnosed and treated between 2007 and 2011...
December 8, 2017: Modern Rheumatology
https://www.readbyqxmd.com/read/29189668/the-role-of-airway-inflammation-and-bronchial-hyperresponsiveness-in-athlete-s-asthma
#4
Julie Stang, Liv Ingunn Bjoner Sikkeland, Ellen Tufvesson, Are Martin Holm, Trine Stensrud, Kai-Håkon Carlsen
PURPOSE: Asthma is frequently reported in endurance athletes. The aim of the present study was to assess the long-term airway inflammatory response to endurance exercise in high-level athletes with and without asthma. METHODS: In a cross-sectional design, 20 asthmatic athletes (10 swimmers, 10 cross-country skiers), 19 athletes without asthma (10 swimmers, 9 cross-country skiers) and 24 healthy non-athletes completed methacholine bronchial challenge, lung function tests and sputum induction on two separate days...
November 7, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/29188320/characterization-of-a-new-ezakiella-isolated-from-the-human-vagina-genome-sequence-and-description-of-ezakiella-massiliensis-sp-nov
#5
Khoudia Diop, Claudia Andrieu, Caroline Michelle, Nicholas Armstrong, Fadi Bittar, Florence Bretelle, Pierre-Edouard Fournier, Didier Raoult, Florence Fenollar
The study of the vaginal microbiota using the "culturomics concept" allowed us to isolate, from the vaginal swab of an asymptomatic 20-year-old woman who had sexual relations with another woman with bacterial vaginosis, an unknown Gram-positive anaerobic coccus-shaped bacterium that was designated strain Marseille-P2951T and characterized using taxono-genomics. Strain Marseille-P2951T is non-motile and non-spore forming and exhibits catalase and oxidase activities. Its 16S rRNA gene-based identification showed 98...
November 29, 2017: Current Microbiology
https://www.readbyqxmd.com/read/29177432/diagnostic-nuclear-medicine-for-paediatric-patients-in-australia-assessing-the-individual-s-dose-burden
#6
Marissa L Bartlett, Anna Forsythe, Zoe Brady, John D Mathews
We report data for all Australians aged 0-19 y who underwent publicly funded nuclear medicine studies between 1985 and 2005, inclusive. Radiation doses were estimated for individual patients for 95 different types of studies. There were 374 848 occasions of service for 277 511 patients with a collective effective dose of 1123 Sievert (Sv). Most services were either bone scans (45%) or renal scans (29%), with renal scans predominating at younger ages and bone scans at older ages. This pattern persisted despite a 4-fold increase in the annual number of procedures...
November 21, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29157342/molecular-biological-effects-of-weightlessness-and-hypergravity-on-intervertebral-disc-degeneration
#7
Di Wu, Chao Zheng, Ji Wu, Rongrong Huang, Xuanyu Chen, Tong Zhang, Lili Zhang
INTRODUCTION: The rate of intervertebral disc degeneration (IVDD) is influenced by environmental factors. Extracellular matrix (ECM) destruction and apoptosis of intervertebral disc cells are major characteristics of IVDD. ECM degradation is closely linked to up-regulation of matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs (TIMP). This study aimed to elucidate the molecular biological changes during IVDD under conditions of weightlessness and hypergravity. METHODS: A total of 120 rabbits were divided randomly into four groups: control group, weightlessness group, hypergravity group, and mixed (hypergravity + weightlessness) group...
December 1, 2017: Aerospace Medicine and Human Performance
https://www.readbyqxmd.com/read/29141060/efficacy-of-low-fluence-nd-yag-1064-nm-laser-for-the-treatment-of-post-inflammatory-hyperpigmentation-in-the-axillary-area
#8
Sahar Ghannam, Fatemah K Al Otabi, Konstantin Frank, Sebastian Cotofana
<p>OBJECTIVE: Post-inflammatory hyperpigmentation results in aesthetically unpleasant discoloration of the skin in the affected area. The efficacy of low-fluence Q-switched 1064-nm Nd:YAG laser has so far not been evaluated for the treatment of the axilla. This observational study was designed to evaluate whether the application of the laser treatment can satisfactorily reduce axillary hyperpigmentation. MATERIAL AND METHODS: 17 females (mean age, 34.27 ± 9.24; range, 19-48) were treated in a single center between 2014 and 2016 for post-inflammatory hyperpigmentation of the axillary area...
November 1, 2017: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29115287/consumer-product-chemical-weight-fractions-from-ingredient-lists
#9
Kristin K Isaacs, Katherine A Phillips, Derya Biryol, Kathie L Dionisio, Paul S Price
Assessing human exposures to chemicals in consumer products requires composition information. However, comprehensive composition data for products in commerce are not generally available. Many consumer products have reported ingredient lists that are constructed using specific guidelines. A probabilistic model was developed to estimate quantitative weight fraction (WF) values that are consistent with the rank of an ingredient in the list, the number of reported ingredients, and labeling rules. The model provides the mean, median, and 95% upper and lower confidence limit WFs for ingredients of any rank in lists of any length...
November 8, 2017: Journal of Exposure Science & Environmental Epidemiology
https://www.readbyqxmd.com/read/29113653/trends-in-adherence-to-nccn-guidelines-for-breast-conserving-therapy-in-women-with-stage-i-and-ii-breast-cancer-analysis-of-the-1998-2008-national-cancer-data-base
#10
Jilma L Patrick, Michelle E Hasse, Joe Feinglass, Seema A Khan
OBJECTIVE: To examine temporal trends in guideline adherence for breast cancer local therapy, by race/ethnicity, socioeconomic and insurance status. BACKGROUND: Treatment guidelines recommend breast conserving therapy (BCT) for women with small cancers, but have been unevenly applied. A better understanding of time-trends in guideline adherence may point to interventions for correction. METHODS: Patients with tumors ≤2 cm (n = 1,081,075) were identified from 1123 NCDB hospitals, dividing the interval 1998-2011 into 5 segments...
December 2017: Surgical Oncology
https://www.readbyqxmd.com/read/29112279/nutrients-intake-and-serum-calcium-and-phosphorus-levels-an%C3%A2-evidence-based-study
#11
Zahra Jafari Giv, Amir Avan, Farshid Hamidi, Maryam Tayefi, Sayyed Saeid Khayyatzadeh, Ali Javandoost, Mohsen Nematy, Gordon A Ferns, Majid Ghayour Mobarhan
INTRODUCTION: Dietary calcium and phosphorus appear to be important determinants of dyslipidemia and hypertension. We have investigated (1) the prevalence of hypocalcemia and hypophosphatemia in an Iranian population, and (2) the association between nutrient's intake and serum levels of calcium and phosphorus. METHODS: A total of 908 individuals were enrolled using a stratified-cluster sampling method from the Mashhad stroke and heart atherosclerosis disorder (MASHHAD) study...
November 7, 2017: Journal of Clinical Laboratory Analysis
https://www.readbyqxmd.com/read/29103861/public-and-private-hospital-care-disparities-of-ischemic-stroke-in-mexico-results-from-the-primer-registro-mexicano-de-isquemia-cerebral-premier-study
#12
José Luis Ruiz-Sandoval, María Eugenia Briseño-Godínez, Erwin Chiquete-Anaya, Antonio Arauz-Góngora, Rogelio Troyo-Sanromán, Juan Didier Parada-Garza, Alma Ramos-Moreno, Fernando Barinagarrementería, Luis Manuel Murillo-Bonilla, Carlos Cantú-Brito
BACKGROUND AND AIMS: Mortality and bad outcome by stroke are higher in developing countries than in industrialized countries. Health-care system efficiency could explain these disparities. Our objective was to identify the impact on short- and middle-term outcomes of patients with acute ischemic stroke (AIS) among public and private Mexican medical care. METHODS: We analyzed data from patients with AIS included in the Primer Registro Mexicano de Isquemia Cerebral (PREMIER) study...
November 2, 2017: Journal of Stroke and Cerebrovascular Diseases: the Official Journal of National Stroke Association
https://www.readbyqxmd.com/read/29099700/-study-of-the-ptpn22-gene-in-children-with-type-1-diabetes-mellitus-in-the-azerbaijani-population
#13
G Ahmadov
The PTPN22 gene was studied in 160 children with type 1 diabetes mellitus under the age of 18 years and in 271 healthy children. Of the 160 patients, 50.6% (n=81) were boys, 49.4% (n=79) were girls. The average age of diabetic children was 9.1 years. The survey was conducted on the basis of the Children's Clinical Hospital No. 6 in Baku city. For all patients, a special questionnaire was filled out. Only children of Azerbaijani nationality were included in the study. As a comparison group, 271 students of the Medical College No...
October 2017: Georgian Medical News
https://www.readbyqxmd.com/read/29069077/functional-convergence-of-histone-methyltransferases-ehmt1-and-kmt2c-involved-in-intellectual-disability-and-autism-spectrum-disorder
#14
Tom S Koemans, Tjitske Kleefstra, Melissa C Chubak, Max H Stone, Margot R F Reijnders, Sonja de Munnik, Marjolein H Willemsen, Michaela Fenckova, Connie T R M Stumpel, Levinus A Bok, Margarita Sifuentes Saenz, Kyna A Byerly, Linda B Baughn, Alexander P A Stegmann, Rolph Pfundt, Huiqing Zhou, Hans van Bokhoven, Annette Schenck, Jamie M Kramer
Kleefstra syndrome, caused by haploinsufficiency of euchromatin histone methyltransferase 1 (EHMT1), is characterized by intellectual disability (ID), autism spectrum disorder (ASD), characteristic facial dysmorphisms, and other variable clinical features. In addition to EHMT1 mutations, de novo variants were reported in four additional genes (MBD5, SMARCB1, NR1I3, and KMT2C), in single individuals with clinical characteristics overlapping Kleefstra syndrome. Here, we present a novel cohort of five patients with de novo loss of function mutations affecting the histone methyltransferase KMT2C...
October 2017: PLoS Genetics
https://www.readbyqxmd.com/read/29065373/the-mutual-restraint-effect-between-the-expansion-of-alternanthera-philoxeroides-mart-griseb-and-cadmium-mobility-in-aquatic-environment
#15
Jian Li, Zhiwei Du, Chris B Zou, Zhicong Dai, Daolin Du, Chongling Yan
Alternanthera philoxeroides (Mart.) Griseb is one of the most malignant weeds in its invision habitats. While in the cadmium-contaminated aquatic environment, does A. philoxeroides possess good tolerance and adaptability? To demonstrate the effects of cadmium on A. philoxeroides in the polluted water bodies, a hydroponic stress experiment was conducted over a gradient of Cd concentrations (0, 2.5 and 5mg/l) in triplicate. The seedlings were cultured in a greenhouse and harvested on days 0, 10, 20, 30 and 40, respectively...
October 21, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/28988139/rifm-fragrance-ingredient-safety-assessment-%C3%AE-methylphenethyl-alcohol-cas-registry-number-1123-85-9
#16
A M Api, D Belsito, D Botelho, D Browne, M Bruze, G A Burton, J Buschmann, M L Dagli, M Date, W Dekant, C Deodhar, M Francis, A D Fryer, K Joshi, S La Cava, A Lapczynski, D C Liebler, D O'Brien, R Parakhia, A Patel, T M Penning, G Ritacco, J Romine, D Salvito, T W Schultz, I G Sipes, Y Thakkar, E H Theophilus, A K Tiethof, Y Tokura, S Tsang, J Wahler
No abstract text is available yet for this article.
October 5, 2017: Food and Chemical Toxicology
https://www.readbyqxmd.com/read/28956542/prevalence-genotype-distribution-and-temporal-dynamics-of-human-papillomavirus-infection-in-a-population-in-southern-italy
#17
Raffaele Del Prete, Luigi Ronga, Grazia Addati, Raffaella Magrone, Domenico Di Carlo, Giuseppe Miragliotta
Human papillomavirus (HPV) is considered the most important risk factor for the development of ano-genital region cancer in both women and men. Whereas low-risk genotypes are responsible for cutaneous and genital lesions, high-risk genotypes are associated with ano-genital cancer. The aim of this study was to retrospectively analyse the prevalence, genotype distribution and temporal dynamics of HPV infection in 2312 specimens from 2312 subjects (2149 women and 163 men) who attended the laboratory of molecular biology, UOC Microbiology and Virology, Azienda Ospedaliera-Universitaria, Policlinico of Bari, Italy...
September 1, 2017: Le Infezioni in Medicina
https://www.readbyqxmd.com/read/28881680/identification-of-dysregulated-long-non-coding-rnas-micrornas-mrnas-in-tnm-i-stage-lung-adenocarcinoma
#18
Ziqiang Tian, Shiwang Wen, Yuefeng Zhang, Xinqiang Shi, Yonggang Zhu, Yanzhao Xu, Huilai Lv, Guiying Wang
Lung adenocarcinoma (LUAD) is the primary subtype in lung cancer, which is the leading cause of cancer-related death worldwide. This study aimed to investigate the aberrant expression profiling of long non-coding RNA (lncRNA) in TNM I stage (stage I) LUAD. The lncRNA/mRNA/miRNA expression profiling of stage I LUAD and adjacent non-tumor tissues from 4 patients were measured by RNA-sequencing. Total of 175 differentially expressed lncRNAs (DELs), 1321 differentially expressed mRNAs (DEMs) and 94 differentially expressed microRNAs (DEMIs) were identified in stage I LUAD...
August 1, 2017: Oncotarget
https://www.readbyqxmd.com/read/28875345/modified-hyperbranched-polyglycerol-as-dispersant-for-size-control-and-stabilization-of-gold-nanoparticles-in-hydrocarbons
#19
Yanyu Shen, Guijin He, Yongsheng Guo, Hujun Xie, Wenjun Fang
Hyperbranched polyglycerol (HPG) is modified with dodecanethiol (DS) via the "thiol-ene" click reaction to obtain an amphiphilic product DSHPG. The molecular structures of DSHPG samples are characterized by NMR, FTIR, and GPC, and the thermal behaviors are characterized by DSC and TGA. Gold nanoparticles (Au NPs) are prepared with DSHPG as the stabilizer and surface-modification reagent. The size of Au NPs can be tuned by changing the molecular weight of HPG. It is observed that the HPG molecular weights of 1123, 3826, and 55,075 lead to the NP diameters of 4...
September 6, 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28836882/erratum-lin-and-karduna-2017
#20
Casey Gentis
Come from the Glenohumeral Joint, "in J Appl Biomech. 33(1):32-38, https://doi.org/10.1123/jab.2016-0034 , Figure 3c was a duplicate of Figure 3b and was therefore incorrect. The online version of this article has been corrected; we apologize for this error.
August 24, 2017: Journal of Applied Biomechanics
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