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Alexander C Falkentoft, Rasmus Rørth, Kasper Iversen, Dan E Høfsten, Henning Kelbæk, Lene Holmvang, Martin Frydland, Mikkel M Schoos, Steffen Helqvist, Anna Axelsson, Peter Clemmensen, Erik Jørgensen, Kari Saunamäki, Hans-Henrik Tilsted, Frants Pedersen, Christian Torp-Pedersen, Klaus F Kofoed, Jens P Goetze, Thomas Engstrøm, Lars Køber
BACKGROUND: Midregional proadrenomedullin (MR-proADM) has demonstrated prognostic potential after myocardial infarction (MI). Yet, the prognostic value of MR-proADM at admission has not been examined in patients with ST-segment-elevation MI (STEMI). METHODS AND RESULTS: The aim of this substudy, DANAMI-3 (The Danish Study of Optimal Acute Treatment of Patients with ST-segment-elevation myocardial infarction), was to examine the associations of admission concentrations of MR-proADM with short- and long-term mortality and hospital admission for heart failure in patients with ST-segment-elevation myocardial infarction...
May 18, 2018: Journal of the American Heart Association
Daimeng Zhang, Weisong Wan, Tongtong Kong, Ming Zhang, Jude Juventus Aweya, Yi Gong, Shengkang Li
The clip domain serine proteinases (clip-SPs) play vital roles in embryonic development and in various innate immune functions in invertebrates such as antimicrobial activity, cell adhesion, hemolymph clotting, pattern recognition and regulation of the prophenoloxidase system. However, little is known about the role of the clip domain serine proteinase in Scylla paramamosain (designated SpcSP) immunity. In the present study, we cloned a clip-SP from S. paramamosain hemocytes using rapid amplification of cDNA end (RACE) approach...
May 7, 2018: Fish & Shellfish Immunology
Diana A Santos, Pedro B Júdice, João P Magalhães, Inês R Correia, Analiza M Silva, Fátima Baptista, Luís B Sardinha
We aimed to describe ST and its patterns on a national level. A hip-worn accelerometer (ActiGraph GT1M) was used to collect data during waking hours from 4575 Portuguese' participants from 2007-2009 (2683 females) aged 10-102 years old. Data was presented by sex, in 5-years age intervals, and by adolescents (n=2833), adults (n=1122), and older adults (n=620). Lambda-mu-sigma (LMS) smoothed percentile curves were estimated. Girls, women, and older women spent 61, 57, and 64% of wear time in ST, respectively...
May 10, 2018: Journal of Sports Sciences
Jasmine A Luzum, Edward Peterson, Jia Li, Ruicong She, Hongsheng Gui, Bin Liu, John A Spertus, Yigal M Pinto, L Keoki Williams, Hani N Sabbah, David E Lanfear
BACKGROUND: It remains unclear whether beta-blockade is similarly effective in black patients with heart failure and reduced ejection fraction as in white patients, but self-reported race is a complex social construct with both biological and environmental components. The objective of this study was to compare the reduction in mortality associated with beta-blocker exposure in heart failure and reduced ejection fraction patients by both self-reported race and by proportion African genetic ancestry...
May 8, 2018: Journal of the American Heart Association
Matthew D L O'Connell, Megan M Marron, Robert M Boudreau, Mark Canney, Jason L Sanders, Rose Anne Kenny, Stephen B Kritchevsky, Tamara B Harris, Anne B Newman
Background: Baseline scores on a Healthy Aging Index (HAI), including 5 key physiological domains, strongly predict health outcomes. This study aimed to characterize 9-year changes in a HAI and explore their relationship to subsequent mortality. Methods: Data are from the Health, Aging and Body Composition study of well-functioning adults aged 70-79. A HAI, which ranges from 0-10, was constructed at year 1 and year 10 of the study including systolic blood pressure, forced expiratory volume, digit symbol substitution test, cystatin C and fasting glucose...
May 4, 2018: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
Markus Hartenbach, Stefan Weber, Magdalena Pilz, Sabrina Hartenbach, Mathias J Zacherl, Philipp M Paprottka, Reinhold Tiling, Peter Bartenstein, Marcus Hacker, Alexander R Haug, Nathalie L Albert
AIM: The aim of this study was to retrospectively analyze the prognostic value of combined Tc-macroaggregated albumin (MAA) SPECT/CT and [F]-fluoroethylcholine (FEC) PET/CT before radioembolization for survival of patients with intermediate-stage hepatocellular carcinoma. METHODS: Twenty-four patients with known hepatocellular carcinoma Barcelona Clinic Liver Cancer stage B were eligible for this analysis. All patients were scheduled for radioembolization and received a pretherapeutic [F]FEC PET/CT scan as well as Tc-MAA SPECT/CT for hepatopulmonary shunting...
April 13, 2018: Clinical Nuclear Medicine
Laszlo Ujj
We report the construction and characterization of a coherent Raman tabletop system utilizing a novel astigmatic optical focusing geometry, a broadband nanosecond optical parametric oscillator and volumetric Bragg filters assisting 3CBCRS measuring system for the first time. In order to illustrate the versatility of the measurements and reveal the molecular information obtainable, two well-characterized chemicals were selected. Polarization sensitive epi-detected 3CBCRS spectra of liquid CCl4 and calcite crystal were recorded and analyzed...
March 14, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
Gayatri Singh, Babita Kumari, Geetgovind Sinam, Kriti, Navin Kumar, Shekhar Mallick
Fluorine is an essential element required in trace amounts but gets toxic for human beings at levels more than 1.5 mg F- L-1 primarily through drinking contaminated water. It is the 13th most abundant element and constitutes about 0.06-0.09% in the earth crust. It is electronegative in aqueous medium forming fluoride ion (F- ). Fluoride contamination in the environment occurs mostly due to anthropogenic and geogenic sources. Fluoride is widely distributed in all components of environment, air (0.1-0.6 μg L-1 ) soils (150-400 mg Kg-1 ) rocks (100-2000 mg Kg-1 ), plant (0...
April 9, 2018: Environmental Pollution
Chin-Wei Sher, Chih-Hao Lin, Huang-Yu Lin, Chien-Chung Lin, Che-Hsuan Huang, Kuo-Ju Chen, Jie-Ru Li, Kuan-Yu Wang, Hsien-Hao Tu, Chien-Chung Fu, Hao-Chung Kuo
Correction for 'A high quality liquid-type quantum dot white light-emitting diode' by Chin-Wei Sher et al., Nanoscale, 2016, 8, 1117-1122.
March 29, 2018: Nanoscale
Caroline A Smith, Kate M Levett, Carmel T Collins, Mike Armour, Hannah G Dahlen, Machiko Suganuma
BACKGROUND: Many women would like to avoid pharmacological or invasive methods of pain management in labour and this may contribute to the popularity of complementary methods of pain management. This review examined currently available evidence on the use of relaxation therapies for pain management in labour. This is an update of a review first published in 2011. OBJECTIVES: To examine the effects of mind-body relaxation techniques for pain management in labour on maternal and neonatal well-being during and after labour...
March 28, 2018: Cochrane Database of Systematic Reviews
Guangxian Zhou, Danju Kang, Sen Ma, Xingtao Wang, Ye Gao, Yuxin Yang, Xiaolong Wang, Yulin Chen
BACKGROUND: Cashmere is a keratinized product derived from the secondary hair follicles (SHFs) of cashmere goat skins. The cashmere fiber stops growing following the transition from the actively proliferating anagen stage to the apoptosis-driven catagen stage. However, little is known regarding the molecular mechanisms responsible for the occurrence of apoptosis in SHFs, especially as pertains to the role of non-coding RNAs (ncRNAs) and their interactions with other molecules. Hair follicle (HF) degeneration is caused by localized apoptosis in the skin, while anti-apoptosis pathways may coexist in adjacent HFs...
March 27, 2018: BMC Genomics
T Sinegre, C Duron, T Lecompte, B Pereira, S Massoulier, G Lamblin, A Abergel, A Lebreton
Essentials The role of increased factor VIII in cirrhosis-induced hypercoagulability has never been demonstrated. Factor VIII and protein C effects were characterized by thrombin generation with thrombomodulin. Factor VIII elevation plays a significant role in cirrhosis-induced plasma hypercoagulability. Only protein C and factor VIII normalization led to thrombin generation similar to controls. SUMMARY: Background In cirrhosis, thrombin generation (TG) studied in the presence of thrombomodulin (TM) indicates plasma hypercoagulability...
March 26, 2018: Journal of Thrombosis and Haemostasis: JTH
Debbie L Croyden, Helen A Vidgen, Emma Esdaile, Emely Hernandez, Anthea Magarey, Carly J Moores, Lynne Daniels
BACKGROUND: PEACH™QLD translated the PEACH™ Program, designed to manage overweight/obesity in primary school-aged children, from efficacious RCT and small scale community trial to a larger state-wide program. This paper describes the lessons learnt when upscaling to universal health coverage. METHODS: The 6-month, family-focussed program was delivered in Queensland, Australia from 2013 to 2016. Its implementation was planned by researchers who developed the program and conducted the RCT, and experienced project managers and practitioners across the health continuum...
March 13, 2018: BMC Public Health
Dawen Gao, Yu Tao, Yuan Fu, Hong Liang
Microbial biofilms are multicellular communities of sessile microorganisms encased by the hydrated polymeric matrix. They have significant influences on both aquatic/terrestrial ecosystem and anthropogenic activities. Taking advantage of the governing features of selective stress (Tan and Ng in Water Res 42:1122-1132, 2008; Wei in Water Res 45:863-871, 2011; Dereli in Water Res 59C:11-22, 2014), the evenness of microbial communities in a membrane-centered mesocosm was successfully manipulated. By measuring the biofilm growing rates under different evenness levels of communities, an evenly distributed community favors the formation of biofilms was observed...
March 8, 2018: Microbial Ecology
Asger Granfeldt, Mads Wissenberg, Steen Møller Hansen, Freddy K Lippert, Christian Torp-Pedersen, Søren Helbo Skaarup, Lars W Andersen, Erika Frischknecht Christensen, Christian Fynbo Christiansen
INTRODUCTION: Chronic obstructive pulmonary disease (COPD) is associated with a non-shockable rhythm as presenting rhythm in out-of-hospital cardiac arrest (OHCA). Whether the severity of the underlying disease is related to presenting rhythm is unknown. We hypothesized that increased severity of COPD in OHCA patients is associated with an increased prevalence of non-shockable rhythm. METHODS: This study included OHCA patients ≥40 years from the Danish Cardiac Arrest Registry (2001-2014)...
May 2018: Resuscitation
Patrick O Richard, Ardalan E Ahmad, Shaheena Bashir, Alexandre Zlotta, Bimal Bhindi, Ricardo Leao, Madhur Nayan, Aza Mohammed, Neil E Fleshner, Girish S Kulkarni
INTRODUCTION: Non-muscle invasive bladder cancer (NMIBC) accounts for 75-85% of all bladder cancers (UBC). Many UBC patients are also afflicted by diabetes mellitus (DM). It has been postulated that several oral hypoglycemic agents could impact disease-specific survival (DSS), but the data are sparse among NMIBC patients. Our primary objective was to evaluate the impact of metformin on DSS and overall survival (OS) in NMIBC patients. METHODS: This is a retrospective, population-based study that used linked administrative databases to identify diabetic patients ≥66 years who were subsequently diagnosed with NMIBC in Ontario, between 1992 and 2012...
February 23, 2018: Canadian Urological Association Journal, Journal de L'Association des Urologues du Canada
Hyo-Joon Yang, Min-Jung Kwon, Yoosoo Chang, Seul-Ki Song, Kwang-Sung Ahn, Han-Na Kim, Yeojun Yun, Hyung-Lae Kim, Dong Il Park
GOALS AND BACKGROUND: This study aimed to compare differences in the fecal microbiota according to the risk of advanced colorectal neoplasia (ACN) based on a risk-score model in a large Korean cohort. STUDY: Stool samples were collected from 1122 health screening recipients: 404 enrolled in the average risk (AR) group, 514 in the moderate risk (MR) group, and 204 in the high risk (HR) group, in accordance with their risk of ACN. The fecal microbiota was characterized using pyrosequencing of the V3-V4 region of the 16S rRNA genes...
February 9, 2018: Journal of Clinical Gastroenterology
Sajad Jamalpour, Shamsul Mohd Zain, Maryam Mosavat, Zahurin Mohamed, Siti Zawiah Omar
BACKGROUND: Although the influence of a common variant in the glucokinase regulatory gene (GCKR rs780094) in type 2 diabetes mellitus has been well documented, less data however, is available of its role in gestational diabetes mellitus (GDM). We carried out a case control study to assess the association between GCKR rs780094 and GDM in the Asian, and also a meta-analysis to further assess the strength of the association. METHODS: Demographic, clinical and genotype data were determined for 1122 women (267 cases and 855 controls) recruited from the University of Malaya Medical Centre in the Klang Valley, Kuala Lumpur...
April 15, 2018: Gene
Roman G Kuperman, Ronald T Checkai, Michael Simini, Geoffrey I Sunahara, Jalal Hawari
Individual effects of nitrogen-based energetic materials (EMs) 2,4-dinitrotoluene (2,4-DNT), 2-amino-4,6-dinitrotoluene (2-ADNT), 4-amino-2,6-dinitrotoluene (4-ADNT), nitroglycerin (NG), and 2,4,6,8,10,12-hexanitrohexaazaisowurtzitane (CL-20) on litter decomposition, an essential biologically-mediated soil process, were assessed using Orchard grass (Dactylis glomerata) straw in Sassafras sandy loam (SSL) soil, which has physicochemical characteristics that support "very high" qualitative relative bioavailability for organic chemicals...
May 30, 2018: Ecotoxicology and Environmental Safety
Marion J Torres, Jean-Marc Sabate, Michel Bouchoucha, Camille Buscail, Serge Hercberg, Chantal Julia
Introduction: Diet plays an important role for patients with irritable bowel syndrome (IBS). The aim of this study was to compare the diets in terms of food consumption and nutrient intake between subjects with IBS and controls in a large French population. Methods: This study included 36,448 subjects from the Nutrinet-Santé cohort study, who completed a questionnaire pertaining to functional bowel disorders based on the Rome III criteria. Dietary data were obtained from at least three self-administered 24 h records via the internet...
2018: Therapeutic Advances in Gastroenterology
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