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https://www.readbyqxmd.com/read/28633287/genetic-diseases-and-aneuploidies-can-be-detected-with-a-single-blastocyst-biopsy-a-successful-clinical-approach
#1
Maria Giulia Minasi, Francesco Fiorentino, Alessandra Ruberti, Anil Biricik, Elisabetta Cursio, Ettore Cotroneo, Maria Teresa Varricchio, Matteo Surdo, Francesca Spinella, Ermanno Greco
STUDY QUESTION: Can simultaneous detection of aneuploidies and genetic diseases or chromosomal aberrations in blastocysts reduce the chance of transferring embryos with low implantation potential, guaranteeing good clinical outcomes? SUMMARY ANSWER: The screening for chromosomal aneuploidies revealed that 50.6% of blastocysts diagnosed free of genetic disease or balanced, were aneuploid, therefore avoiding the transfer of blastocysts potentially resulting in implantation failures, miscarriages, or in some cases, in health affected live births...
June 12, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28610175/seven-new-species-of-i-bibloplectus-i-reitter-coleoptera-staphylinidae-pselaphinae-from-eastern-united-states-with-notes-on-distributions-of-previously-described-species
#2
Brittany E Owens, Christopher E Carlton
Seven new species in the genus Bibloplectus Reitter, 1881 are described: Bibloplectus ellisi Owens and Carlton, new species; Bibloplectus levis Owens and Carlton, new species; Bibloplectus parki Owens and Carlton, new species; Bibloplectus quadratum Owens and Carlton, new species; Bibloplectus suteri Owens and Carlton, new species; Bibloplectus steevesi Owens and Carlton, new species; and Bibloplectus tishechkini Owens and Carlton, new species. New species are integrated into the previously published key, supported by illustrations of diagnostic characters, and a revised key and checklist to eastern North American species is presented...
March 13, 2017: Zootaxa
https://www.readbyqxmd.com/read/28599187/the-impact-of-antecedent-trauma-exposure-and-mental-health-symptoms-on-the-post-deployment-mental-health-of-afghanistan-deployed-australian-troops
#3
Amelia K Searle, Miranda Van Hooff, Ellie R Lawrence-Wood, Blair S Grace, Elizabeth J Saccone, Carol P Davy, Michelle Lorimer, Alexander C McFarlane
BACKGROUND: Both traumatic deployment experiences and antecedent traumas increase personnel's risk of developing PTSD and depression. However, only cross-sectional studies have assessed whether antecedent trauma moderates stress reactions to deployment experiences. This study prospectively examines whether antecedent trauma moderates the association between deployment trauma and post-deployment PTSD and depressive symptoms after accounting for antecedent mental health problems, in a large Australian Defence Force (ADF) sample...
May 30, 2017: Journal of Affective Disorders
https://www.readbyqxmd.com/read/28580671/student-voices-perspectives-on-peer-to-peer-sexual-health-education
#4
Carolyn Layzer, Lauren Rosapep, Sherry Barr
BACKGROUND: This process study is a companion to a randomized evaluation of a school-based, peer-led comprehensive sexual health education program, Teen Prevention Education Program (Teen PEP), in which 11th- and 12th-grade students are trained by school health educators to conduct informative workshops with ninth-grade peers in schools in North Carolina. The process study was designed to understand youth participants' perspectives on the program in order to gain insight into program effectiveness...
July 2017: Journal of School Health
https://www.readbyqxmd.com/read/28569401/macrophage-inhibitory-cytokine-1-growth-differentiation-factor-15-as-a-predictor-of-colonic-neoplasia
#5
M Danta, D A Barber, H P Zhang, M Lee-Ng, S W L Baumgart, V W W Tsai, Y Husaini, M Saxena, C P Marquis, W Errington, S Kerr, S N Breit, D A Brown
BACKGROUND: Serum macrophage inhibitory cytokine-1 (MIC-1/GDF15) concentration has been associated with colonic adenomas and carcinoma. AIMS: To determine whether circulating MIC-1/GDF15 serum concentrations are higher in the presence of adenomas and whether the level decreases after excision. METHODS: Patients were recruited prospectively from a single centre and stratified into five groups: no polyps (NP); hyperplastic polyps (HP); sessile serrated ademona (SSA); adenomas (AP); and colorectal carcinoma (CRC)...
June 1, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28537984/postoperative-high-sensitivity-troponin-and-its-association-with-30-day-and-12-month-all-cause-mortality-in-patients-undergoing-on-pump-cardiac-surgery
#6
Eckhard Mauermann, Daniel Bolliger, Jens Fassl, Martin Grapow, Esther E Seeberger, Manfred D Seeberger, Miodrag Filipovic, Giovanna A L Lurati Buse
BACKGROUND: Troponin T is a predictor of cardiac morbidity and mortality after cardiac surgery with most data examining fourth generational troponin T assays. We hypothesize that postoperative high-sensitivity troponin T (hsTnT) measured in increments of the upper limit of the norm independently predicts 30-day all-cause mortality. METHODS: We included consecutive patients undergoing on-pump cardiac surgery from February 2010 to March 2012 in a prospective cohort that measured hsTnT at 0600 of the first and second postoperative day...
May 19, 2017: Anesthesia and Analgesia
https://www.readbyqxmd.com/read/28522129/provision-of-prehospital-emergency-medical-services-in-punjab-pakistan-case-study-of-a-public-sector-provider
#7
Veena M Sriram, Rizwan Naseer, Adnan A Hyder
BACKGROUND: The availability and quality of emergency medical services in low- and middle-income countries, including Pakistan, are extremely limited. New models for prehospital emergency medical services provision have recently emerged across multiple sectors, and research on these models is urgently needed to inform current and future emergency medical services systems in low-resource settings. The objective of this case study was to provide a comprehensive description of the organizational structure and service delivery model of a public sector provider in the Punjab Province of Pakistan, Rescue 1122, with a focus on operations in Lahore...
May 15, 2017: Surgery
https://www.readbyqxmd.com/read/28486709/anhedonia-its-dynamic-relations-with-craving-negative-affect-and-treatment-during-a-quit-smoking-attempt
#8
Jessica W Cook, Stephanie T Lanza, Wanghuan Chu, Timothy B Baker, Megan E Piper
Introduction: Research shows that abstinence from tobacco leads to a withdrawal-related decrement in responsivity to nondrug rewards (ie, anhedonia). However, it remains unclear how anhedonia relates to other key withdrawal symptoms and withdrawal-related constructs over time. We analyzed ecological momentary assessment data to examine whether a decrement in response to rewards during a 10-day period following quitting shows a pattern of associations with other variables (ie, treatment, tobacco dependence, negative affect, and craving) that is consistent with anhedonia being a tobacco withdrawal symptom...
June 1, 2017: Nicotine & Tobacco Research: Official Journal of the Society for Research on Nicotine and Tobacco
https://www.readbyqxmd.com/read/28466138/a-translational-approach-from-an-animal-model-identifies-cd80-as-a-candidate-gene-for-the-study-of-bone-phenotypes-in-postmenopausal-women
#9
L Panach, E Serna, J J Tarín, A Cano, M Á García-Pérez
This study represented a translational study that first compared gene expression of B cells of BM from ovariectomized and control mice, and then analyzed some of the differentially expressed genes in women. Results showed novel genetic associations with bone phenotypes and points to the CD80 gene as relevant in postmenopausal bone loss. INTRODUCTION: Osteoporosis is a multifactorial disease with a strong genetic component. However, to date, research into osteoporosis has only been able to explain a small part of its heritability...
May 2, 2017: Osteoporosis International
https://www.readbyqxmd.com/read/28450552/one-year-costs-of-bilateral-or-single-internal-mammary-grafts-in-the-arterial-revascularisation-trial
#10
Alastair M Gray, Jacqueline Murphy, Douglas G Altman, Umberto Benedetto, Helen Campbell, Marcus Flather, Stephen Gerry, Belinda Lees, David P Taggart
OBJECTIVE: Coronary artery bypass grafting (CABG) using bilateral internal mammary arteries (BIMA) may improve survival over CABG using single internal mammary arteries (SIMA), but may be surgically more complex (and therefore costly) and associated with impaired sternal wound healing. We report, for the first time, a detailed comparison of healthcare resource use and costs over 12 months, as part of the Arterial Revascularisation (ART) Trial. METHODS: 3102 patients in 28 hospitals in seven countries were randomised to CABG surgery using BIMA (n=1548) or SIMA (n=1554)...
April 27, 2017: Heart: Official Journal of the British Cardiac Society
https://www.readbyqxmd.com/read/28404610/hand-exercises-for-patients-with-rheumatoid-arthritis-an-extended-follow-up-of-the-sarah-randomised-controlled-trial
#11
Esther Williamson, Christopher McConkey, Peter Heine, Sukhdeep Dosanjh, Mark Williams, Sarah E Lamb
OBJECTIVES: The Stretching And strengthening for Rheumatoid Arthritis of the Hand (SARAH) randomised controlled trial evaluated the effectiveness of a hand exercise programme and demonstrated it was clinically effective and cost-effective at 12 months. The aim of this extended follow-up was to evaluate the effects of the SARAH programme beyond 12 months. METHODS: Using postal questionnaires, we collected the Michigan Hand Questionnaire hand function (primary outcome), activities of daily living and work subscales, pain troublesomeness, self-efficacy and health-related quality of life...
April 12, 2017: BMJ Open
https://www.readbyqxmd.com/read/28372534/panel-7-otitis-media-treatment-and-complications
#12
Anne G M Schilder, Tal Marom, Mahmood F Bhutta, Margaretha L Casselbrant, Harvey Coates, Marie Gisselsson-Solén, Amanda J Hall, Paola Marchisio, Aino Ruohola, Roderick P Venekamp, Ellen M Mandel
Objective We aimed to summarize key articles published between 2011 and 2015 on the treatment of (recurrent) acute otitis media, otitis media with effusion, tympanostomy tube otorrhea, chronic suppurative otitis media and complications of otitis media, and their implications for clinical practice. Data Sources PubMed, Ovid Medline, the Cochrane Library, and Clinical Evidence (BMJ Publishing). Review Methods All types of articles related to otitis media treatment and complications between June 2011 and March 2015 were identified...
April 2017: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/28321529/the-cumulative-dose-of-gonadotropins-used-for-controlled-ovarian-stimulation-does-not-influence-the-odds-of-embryonic-aneuploidy-in-patients-with-normal-ovarian-response
#13
Lucky Sekhon, Kathryn Shaia, Anthony Santistevan, Karen Hunter Cohn, Joseph A Lee, Piraye Yurttas Beim, Alan B Copperman
OBJECTIVE: Controlled ovarian hyperstimulation (COH) promotes multifollicular growth, increasing the chance of obtaining euploid embryos that will successfully implant. Whether aneuploidy is increased from COH with exogenous gonadotropins interfering with natural selection of dominant follicles is a concern. This study evaluates the association between gonadotropin exposure and aneuploidy. METHODS: This is a retrospective cohort study of 828 patients that underwent 1122 IVF cycles involving controlled ovarian stimulation and trophectoderm biopsy for preimplantation genetic screening (PGS), from 2010 to 2015...
June 2017: Journal of Assisted Reproduction and Genetics
https://www.readbyqxmd.com/read/28301593/knowledge-attitudes-and-practices-of-south-african-healthcare-workers-regarding-the-prevention-and-treatment-of-influenza-among-hiv-infected-individuals
#14
Jazmin Duque, Sisanda Gaga, David Clark, Madeleine Muller, Bulenani Kuwane, Cheryl Cohen, Sibongile Walaza, Stefano Tempia, Puleng Ramatoboe, Tsakani Furumele, Marc-Alain Widdowson, Meredith L McMorrow, Adam L Cohen
BACKGROUND: The South African Department of Health (DOH) publishes annual guidelines identifying priority groups, including immunosuppressed individuals and healthcare workers (HCW), for influenza vaccination and treatment. How these guidelines have impacted HCW and their patients, particularly those infected with HIV, remains unknown. METHODS: We aimed to describe the knowledge, attitudes and practices regarding influenza and the vaccine among South African HCW...
2017: PloS One
https://www.readbyqxmd.com/read/28292744/association-between-trial-registration-and-positive-study-findings-cross-sectional-study-epidemiological-study-of-randomized-trials-esort
#15
Ayodele Odutayo, Connor A Emdin, Allan J Hsiao, Mubeen Shakir, Bethan Copsey, Susan Dutton, Virginia Chiocchia, Michael Schlussel, Peter Dutton, Corran Roberts, Douglas G Altman, Sally Hopewell
Objective To assess whether randomised controlled trials (RCTs) that were registered were less likely to report positive study findings compared with RCTs that were not registered and whether the association varied by funding source.Design Cross sectional study.Study sample All primary RCTs published in December 2012 and indexed in PubMed by November 2013. Trial registration was determined based on the report of a trial registration number in published RCTs or the identification of the trial in a search of trial registries...
March 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28276169/intergenerational-transfers-and-informal-care-for-disabled-elderly-persons-in-china-evidence-from-charls
#16
Xiaoting Liu, Bei Lu, Zhixin Feng
Aiming at 'ageing healthier and ageing better', a certain amount of high-quality informal care should be available for elderly persons with physical disability as formal care is barely accessible in China. The demographic transition and family structural changes have dramatically weakened traditional norms of filial piety and the structure of intergenerational transfers. This article employed nationwide representative data from the first wave (2011) of Chinese Health and Retirement Longitudinal Study (CHARLS) in order to identify the duration of informal care provision at home for frail elders (1122 in rural areas and 577 in urban areas, total 1699), measured in monthly hours, before estimating the associations between intergenerational transfers and the received time of informal care with Tobit Model analysis...
March 9, 2017: Health & Social Care in the Community
https://www.readbyqxmd.com/read/28264511/prevention-of-bacterial-contamination-of-a-silica-matrix-containing-entrapped-%C3%AE-galactosidase-through-the-action-of-covalently-bound-lysozymes
#17
Heng Li, Shuai Li, Pu Tian, Zhuofu Wu, Zhengqiang Li
β-galactosidase was successfully encapsulated within an amino-functionalised silica matrix using a "fish-in-net" approach and molecular imprinting technique followed by covalent binding of lysozyme via a glutaraldehyde-based method. Transmission electron microscopy (TEM), X-ray diffraction (XRD), scanning electron microscopy (SEM), and Fourier transform infrared (FTIR) spectroscopy were used to characterise the silica matrix hosting the two enzymes. Both encapsulated β-galactosidase and bound lysozyme exhibited high enzymatic activities and outstanding operational stability in model reactions...
February 28, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/28260140/complete-nucleotide-sequences-of-m-and-l-rnas-from-a-new-pepper-infecting-tospovirus-pepper-chlorotic-spot-virus
#18
Kuo-Shiou Huang, Chia-Hsing Tai, Ying-Huey Cheng, Shu-Hui Lin, Tsung-Chi Chen, Fuh-Jyh Jan
Pepper chlorotic spot virus (PCSV), newly found in Taiwan, was identified as a new tospovirus based on the molecular characterization of its S RNA. In this study, the complete M and L RNA sequences of PCSV were determined. The M RNA has 4795 nucleotides (nts), encoding the NSm protein of 311 aa (34.5 kDa) in the viral (v) strand and the glycoprotein precursor (Gn/Gc) of 1122 aa (127.6 kDa) in the viral complementary (vc) strand. The L RNA has 8859 nts, encoding the RNA-dependent RNA polymerase (RdRp) of 2873 aa (330...
July 2017: Archives of Virology
https://www.readbyqxmd.com/read/28196696/patients-hospitalized-abroad-as-importers-of-multiresistant-bacteria-a-cross-sectional-study
#19
T Khawaja, J Kirveskari, S Johansson, J Väisänen, A Djupsjöbacka, A Nevalainen, A Kantele
OBJECTIVES: The pandemic spread of multidrug-resistant (MDR) bacteria poses a threat to healthcare worldwide, with highest prevalence in indigent regions of the (sub)tropics. As hospitalization constitutes a major risk factor for colonization, infection control management in low-prevalence countries urgently needs background data on patients hospitalized abroad. METHODS: We collected data on 1122 patients who, after hospitalization abroad, were treated at the Helsinki University Hospital between 2010 and 2013...
February 11, 2017: Clinical Microbiology and Infection
https://www.readbyqxmd.com/read/28180233/abnormal-vaginal-bleeding-in-women-with-venous-thromboembolism-treated-with-apixaban-or-warfarin
#20
Marjolein P A Brekelmans, Luuk J J Scheres, Suzanne M Bleker, Barbara A Hutten, Anne Timmermans, Harry R Büller, Saskia Middeldorp
Abnormal vaginal bleeding can complicate direct oral anticoagulant (DOAC) treatment. We aimed to investigate the characteristics of abnormal vaginal bleeding in patients with venous thromboembolism (VTE) receiving apixaban or enoxaparin/warfarin. Data were derived from the AMPLIFY trial. We compared the incidence of abnormal vaginal bleeding between patients in both treatment arms and collected information on clinical presentation, diagnostic procedures, management and outcomes. In the AMPLIFY trial, 1122 women were treated with apixaban and 1106 received enoxaparin/warfarin...
April 3, 2017: Thrombosis and Haemostasis
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