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Pan Jiang, Qiurong Lv, Tianwen Lai, Feng Xu
Hypomagnesemia is commonly seen but frequently overlooked in critically ill patients in intensive care unit (ICU). However, the strength and consistency of the effect of hypomagnesemia on outcomes in critically ill patients remain controversial. In this report, we performed a systematic review and meta-analysis to evaluate the association of serum magnesium level with prognosis of critically ill patients upon admission to the ICU. A comprehensive search for clinical trials was performed, and ten studies comprising 1122 cases and 630 controls were finally selected for analysis...
October 6, 2016: Shock
A Cicchetti, T Rancati, M Ebert, C Fiorino, F Palorini, A Kennedy, D J Joseph, J W Denham, V Vavassori, G Fellin, B Avuzzi, C Stucchi, R Valdagni
AIM: To investigate late gastrointestinal toxicity in a large pooled population of prostate cancer patients treated with radical radiotherapy. Normal tissue complication probability models were developed for late stool frequency and late rectal pain. METHODS AND MATERIALS: Population included 1336 patients, 3-year minimum follow-up, treated with 66-80Gy. Toxicity was scored with LENT-SOMA-scale. Two toxicity endpoints were considered: grade ⩾2 rectal pain and mean grade (average score during follow-up) in stool frequency >1...
October 6, 2016: Physica Medica: PM
Fashen Chen, Xiaohe Liu, Zhian Zhang, Ning Zhang, Anqiang Pan, Shuquan Liang, Renzhi Ma
Urchin-like cobalt oxide (Co3O4) hollow spheres can be successfully prepared by thermal decomposition of cobalt carbonate hydroxide hydrate (Co(CO3)0.5(OH)·0.11H2O) obtained by template-assisted hydrothermal synthesis. The morphology, crystal structure evolution and thermal decomposition behaviors of the as-prepared products have been carefully investigated. A plausible formation mechanism of the urchin-like Co3O4 hollow spheres in the presence of hexadecyl trimethyl ammonium bromide (CTAB) as the surfactant template is proposed...
September 27, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
N R Aimée, A J van Wijk, M Maltz, M M Varjão, H D Mestrinho, J C Carvalho
OBJECTIVE: This study aimed to assess the extent to which dental caries and fluorosis, in addition to sociodemographic and oral health behavior determinants, impact the oral health-related quality of life (OHRQoL) of adolescents. METHODS: All adolescents attending from sixth to eighth grades in the Region of Itapoã, Federal District of Brazil (n = 1122), were screened, and 618 10-15-year-olds were selected. Parents answered a questionnaire about their family's socioeconomic status...
September 27, 2016: Clinical Oral Investigations
Maral DerSarkissian, Yongling Xiao, Mei Sheng Duh, Patrick Lefebvre, Andrine R Swensen, Christopher F Bell
BACKGROUND: Benign prostatic hyperplasia (BPH) is a common disease in men that is characterized by lower urinary tract symptoms. Pharmacologic treatment with alpha blockers (ABs) and 5-alpha reductase inhibitors (5ARIs) is recommended to alleviate symptoms, prevent disease progression that can lead to complications, and reduce health care costs. OBJECTIVE: To compare clinical, economic, and health care resource utilization outcomes among BPH patients treated with early continuous combination AB and 5ARI therapy (dutasteride vs...
October 2016: Journal of Managed Care & Specialty Pharmacy
Ye Sun, Yaqiang Duan, Liang Hao, Zipeng Xing, Ying Dai, Rui Li, Jinlong Zou
The low electrocatalytic activity for oxygen reduction reaction (ORR) and the high cost of cathode catalyst in microbial fuel cells (MFCs) are the important factors that limit the practical applications. The metal-free nitrogen (N)-doped partly graphitized carbon (NPGC) as cathode catalyst is prepared at different temperatures (700-1050 °C) by using waste cornstalks as the carbon source and melamine as the N source. Scanning electron microscopy, X-ray diffraction, specific surface areas, and transmission electron microscopy have been used, in parallel with electrochemical activity tests including rotating disk electrode (RDE) and power output, to clarify how the active constituents and structure of NPGC influence the MFCs performance...
October 5, 2016: ACS Applied Materials & Interfaces
Tomi E Mäki-Opas, Katja Borodulin, Heli Valkeinen, Sari Stenholm, Anton E Kunst, Thomas Abel, Tommi Härkänen, Leena Kopperoinen, Pekka Itkonen, Ritva Prättälä, Sakari Karvonen, Seppo Koskinen
No abstract text is available yet for this article.
May 2016: Medicine and Science in Sports and Exercise
Yajun Jiang, Dexing Yang, Yuan Yuan, Jian Xu, Dong Li, Jianlin Zhao
A novel method for simultaneous measurement of strain and high temperature using a Type II fiber Bragg grating (FBG) and a miniature fiber Fabry-Perot interferometer (MFFPI) is proposed. The MFFPI is produced by fusion splicing a short section of quartz capillary tube with two single-mode fibers, and then it is exposed by a focused femtosecond laser and a phase mask to inscribe a Type II FBG nearby. The reflection spectrum of this sensor is the superposition of the reflection spectrum of the FBG and the interference fringe of the MFFPI...
August 10, 2016: Applied Optics
Frank Stegemann, Oliver Janka
During phase analytical investigations in the rare-earth element rich side of the ternary system cerium-gold-aluminum, the new ternary rare-earth (RE) gold aluminides with a composition of RE16AuxAl13-x (RE = La-Nd, Sm, x≤ 3.37) have been synthesized first by reactive eutectics of RE/Au with Al. Single crystals of high quality can be obtained by this method. The title compounds can be selectively prepared by annealing arc-melted beads of appropriate composition below the peritectic point of the respective system...
September 21, 2016: Dalton Transactions: An International Journal of Inorganic Chemistry
A Imaz, J Niubó, A D Kashuba, E Ferrer, C Sykes, N Rozas, L Acerete, A Vila, D Podzamczer
OBJECTIVES: The aim of the study was to quantify elvitegravir (EVG) concentrations in the semen of HIV-1-infected men receiving antiretroviral therapy (ART) consisting of an elvitegravir/cobicistat/emtricitabine/tenofovir (EVG/COBI/FTC/TDF) single-tablet regimen. METHODS: A phase IV, cross-sectional study was carried out including HIV-1-infected male adults with suppressed plasma HIV-1 RNA who switched ART to EVG/COBI/FTC/TDF. Total EVG concentrations at the end of the dosing interval (C24 h ) and HIV-1 RNA were measured in paired seminal plasma (SP) and blood plasma (BP) samples 4 weeks after switching to EVG/COBI/FTC/TDF...
August 1, 2016: HIV Medicine
Manlio Cipriani, Maurizio Lunati, Maurizio Landolina, Alessandro Proclemer, Giuseppe Boriani, Renato P Ricci, Roberto Rordorf, Maria Vittoria Matassini, Luigi Padeletti, Saverio Iacopino, Giulio Molon, Giovanni B Perego, Maurizio Gasparini
AIM: Mitral regurgitation (MR) is a common finding in patients with heart failure with debatable effects on prognosis. Reduction in MR is one of the mechanisms by which cardiac resynchronization therapy (CRT) exerts its beneficial effects. We investigated the prognostic impact of baseline MR and MR persistence after CRT on outcomes of treated patients. METHODS AND RESULTS: We prospectively followed 1122 CRT patients (66.4 ± 10.3 years, 78% male) who were stratified according to baseline MR severity as having MR- (degree 0-1; n = 508, 45%) or MR+ (degrees 2-3-4; n = 614, 55%)...
August 2016: European Journal of Heart Failure
Dingxie Liu
The associations of estrogen receptor (ER) and progesterone receptor (PR) pathways with the prognosis of colorectal cancer (CRC) are still controversial. The aim of this study was to readdress these issues by introducing a gene signature-based approach to semiquantitate pathway activity. In this approach, the ER and PR pathway activities in CRC were computed based on the expression profiles of the signature genes of ER and PR pathways, respectively. The results showed that the ER pathway activity was progressively significantly decreased from normal colorectal mucosa, colorectal adenoma to CRC...
August 2016: FEBS Journal
Seon-Cheol Park, Min-Soo Lee, Sang Woo Hahn, Tian-Mei Si, Shigenobu Kanba, Mian-Yoon Chong, Chee Kok Yoon, Pichet Udomratn, Adarsh Tripathi, Norman Sartorius, Naotaka Shinfuku, Margarita M Maramis, Yong Chon Park
OBJECTIVE: Using data from the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) study, we aimed to present the rates and clinical correlates of suicidal thoughts/acts in patients recruited from a total of 40 centres in 10 Asian countries/areas: China, Hong Kong, India, Indonesia, Japan, Korea, Malaysia, Singapore, Taiwan, and Thailand. METHODS: Data from 1122 patients with depressive disorders in the REAP-AD study were used. The ICD-10 was employed to diagnose depressive episodes and recurrent depressive disorder...
June 16, 2016: Acta Neuropsychiatrica
Long-Xi He, Xiao-Qin Wu, Qi Xue, Xiu-Wen Qiu
Pine wilt disease (PWD) caused by the pine wood nematode (PWN), Bursaphelenchus xylophilus, is responsible for devastating epidemics in pine trees in Asia and Europe. Recent studies showed that bacteria carried by the PWN might be involved in PWD. However, the molecular mechanism of the interaction between bacteria and the PWN remained unclear. Now that the whole genome of B. xylophilus (Bursaphelenchus xylophilus) is published, transcriptome analysis is a unique method to study the role played by bacteria in PWN...
2016: International Journal of Molecular Sciences
Loretta A Williams, Chet Bohac, Sharon Hunter, David Cella
PURPOSE: In 1997, Vogelzang et al. reported that 61 % of patients with cancer indicated fatigue impacted daily life more than pain, and only 37 % of oncologists shared this perception. We provide an update to this study, which can help prioritize symptom assessment and management in the clinic. Study aims were to determine and compare perceptions of patients with cancer and health care providers (HCPs) of the impact of fatigue and pain. METHODS: A random sample of patients with cancer was recruited in the USA by Harris Poll Online and Schlesinger Associates...
October 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
Ankush, Amit Dias, Edwin Gomes, Ankush Dessai
INTRODUCTION: Diabetes is a major public health problem in our country and complications of diabetes are a major cause of morbidity and mortality. There is a need to quantify the complications in order to improve our strategies for prevention and management. AIM: To measure the prevalence of complications in type 2 diabetics following up at a tertiary care centre and to study its association with the socio-demographic and clinical parameters. MATERIALS AND METHODS: A retrospective record based study was conducted on 3261 type 2 diabetic patients on insulin therapy, recorded in the diabetic registry maintained at Goa Medical College from Aug 2009 to May 2012...
April 2016: Journal of Clinical and Diagnostic Research: JCDR
C C Kirwan, A C Clarke, S J Howell, J Castle
INTRODUCTION: Circulating tumour cells (CTCs) are a marker of poor prognosis and are associated with increased risk of venous thromboembolism in metastatic breast cancer. AIM: We aimed to correlate presence of CTCs and markers of hyper-coagulability (D-dimer, fibrinogen and thrombin-antithrombin [TAT]) with survival in metastatic breast cancer. MATERIALS AND METHODS: In a prospective study, enumeration of CTCs (CellSearch) and D-dimer, fibrinogen and TAT (ELISA) were measured at a single timepoint in 50 MBC (median age 59, range 36-82) patients undergoing active treatment...
April 2016: Thrombosis Research
Raúl Guillot, Raúl Cortés, Sandra Navarro, Morena Mischitelli, Víctor García-Herranz, Elisa Sánchez, Laura Cal, Juan Carlos Navarro, Jesús M Míguez, Sergey Afanasyev, Aleksei Krasnov, Roger D Cone, Josep Rotllant, Jose Miguel Cerdá-Reverter
Melanocortin signaling is regulated by the binding of naturally occurring antagonists, agouti-signaling protein (ASIP) and agouti-related protein (AGRP) that compete with melanocortin peptides by binding to melanocortin receptors to regulate energy balance and growth. Using a transgenic model overexpressing ASIP, we studied the involvement of melanocortin system in the feeding behaviour, growth and stress response of zebrafish. Our data demonstrate that ASIP overexpression results in enhanced growth but not obesity...
June 2016: Hormones and Behavior
Jurgen Peerlings, Esther G C Troost, Patricia J Nelemans, David C P Cobben, Johannes C J de Boer, Aswin L Hoffmann, Regina G H Beets-Tan
Purpose To summarize existing evidence of thoracic magnetic resonance (MR) imaging in determining the nodal status of non-small cell lung cancer (NSCLC) with the aim of elucidating its diagnostic value on a per-patient basis (eg, in treatment decision making) and a per-node basis (eg, in target volume delineation for radiation therapy), with results of cytologic and/or histologic examination as the reference standard. Materials and Methods A systematic literature search for original diagnostic studies was performed in PubMed, Web of Science, Embase, and MEDLINE...
October 2016: Radiology
Elena Ghanotakis, Theresa Hoke, Rose Wilcher, Samuel Field, Sarah Mercer, Emily A Bobrow, Mary Namubiru, Leila Katirayi, Immaculate Mandera
Men's limited understanding of family planning (FP) and harmful cultural gender norms pose obstacles to women's FP use. Thirty-two model men called 'Emanzis' were recruited from the community in Kabale, Uganda to lead men from their peer group through a 10-session curriculum designed to transform gender norms and motivate men to engage in FP and HIV services. Cross-sectional surveys were conducted before (n = 1251) and after (n = 1122) implementation. The Gender Equitable Men (GEM) Scale was used to assess the effect on gender attitudes...
April 24, 2016: Global Public Health
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