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Seize the day

Haiyan Dong, Longyu Han, Jie Wang, Jingjing Xie, Yu Gao, Fangwei Xie, Lee Jia
Circulating tumor cells (CTCs) are known as the root cause of cancer metastasis that accounts for 90% of cancer death. Owing to the rarity of blood CTCs and their microenvironmental complexity, the existing biotechnology could not precisely capture and apoptosize CTCs in vivo for cancer metastasis prevention. Here, we designed two double strand circular aptamers aimed to simultaneously target MUC1 and HER2 surface biomarkers on mesenchymal cancer cells. The circular aptamers are composed of a capture arm for binding and seizing CTCs and a circular body for resisting degradation by exonucleases...
May 7, 2018: Journal of Controlled Release: Official Journal of the Controlled Release Society
Susanna Vogliardi, Giulia Stocchero, Sergio Maietti, Marianna Tucci, Alessandro Nalesso, Rossella Snenghi, Donata Favretto
BACKGROUND/OBJECTIVE: We report on a case of severe intoxication after insufflation of U- 47700, a synthetic opioid that acts as a selective agonist of the μ-opioid receptor, and is several times more potent than morphine. A man in his 30s was found irresponsive in his apartment and was brought to the emergency department of a local hospital. A comatose state and severe respiratory depression were present. Hetero anamnesis revealed that the patient could have taken the substance named “U- 47700”, bought on the Internet...
May 9, 2018: Current Pharmaceutical Biotechnology
Raimondo Bruno, Methsiri Edirisinghe, Wayne Hall, Jochen F Mueller, Foon Yin Lai, Jake W O'Brien, Phong K Thai
This study aimed to examine associations between the annual average purity of seized illicit drugs and their corresponding load measured in wastewater. Daily loads (averaging 81 samples/year) and purity of seized methamphetamine (average 287 samples/year), cocaine (50/year) and MDMA (70/year) were collected from a catchment that serviced approximately 220,000 persons in Queensland, Australia during 2010-2015. Using regression models for mass load and purity data, we found a strong linear increase in the mass load of methamphetamine detected across study years (363-1126 mg/1000 people/day, R2  = 0...
April 20, 2018: Science of the Total Environment
J Carbó Perseguer, A Madejón Seiz, M Romero Portales, J Martínez Hernández, J S Mora Pardina, J García-Samaniego
INTRODUCTION: Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease that causes severe dysphagia and weight loss. Percutaneous endoscopic gastrostomy (PEG) is currently the technique of choice for the enteral nutrition of these patients. OBJECTIVES: To analyse mortality and complications in a series of patients diagnosed with ALS who underwent PEG, and to evaluate factors related to patient survival after the procedure. MATERIAL AND METHODS: We performed a prospective, observational study including all patients diagnosed with ALS and treated by our hospital's Gastroenterology Department in the period 1997-2013...
March 26, 2018: Neurología: Publicación Oficial de la Sociedad Española de Neurología
Nanette Y Schneider, Frédérique Datiche, Gérard Coureaud
The European rabbit (Oryctolagus cuniculus) is a widely used model in fundamental, medical and veterinary neurosciences. Besides investigations in adults, rabbit pups are relevant to study perinatal neurodevelopment and early behaviour. To date, the rabbit is also the only species in which a pheromone - the mammary pheromone (MP) - emitted by lactating females and active on neonatal adaptation has been described. The MP is crucial since it contributes directly to nipple localisation and oral seizing in neonates, i...
May 2018: Journal of Anatomy
Markus B Skrifvars, Johanna Hästbacka
No abstract text is available yet for this article.
February 2018: Resuscitation
Nathan Esplin, John W Stelzer, Sean All, Sundeep Kumar, Ejaz Ghaffar, Sayed Ali
Brain abscesses are infections of the brain parenchyma that can arise from either contiguous spread from local infection or by hematogenous spread from a distant site. Streptococcus anginosus of the Streptococcus anginosus group (SAG) is a commensal microbe of the mucosae of the oral cavity, gastrointestinal tract, and urogenital tract. We present a case of mono-microbial brain abscess caused by contiguous spread from relatively asymptomatic sinusitis that initially presented as a subdural hemorrhage on computed tomography...
October 4, 2017: Curēus
Richard Heuser
Same day discharge after PCI lags in the USA The radial approach to PCI reduces complications compared to the femoral approach USA physicians need to seize the opportunity to not only perform PCI safely, but with economic responsibility.
November 1, 2017: Catheterization and Cardiovascular Interventions
H Miao, J Hou
Objective: To explore clinical and laboratory factors that influencing treating procedure of cytomegalovirus retinitis (CMVR) after allogeneic bone marrow hematopoietic stem cell transplantation (HSCT). Methods: This is a retrospective case series study. A total of 9 CMVR patients (15 eyes) between January 2016 and March 2017 were included in this study. All patients received intravenous or oral ganciclovir, together with intravitreous injection of ganciclovir alone or combined with foscanet sodium. One day before the first injection, aqueous humor samples from the affected eyes were collected, and CMV-DNA and interleukin-8 (IL-8) level were examined...
October 11, 2017: [Zhonghua Yan Ke za Zhi] Chinese Journal of Ophthalmology
Gabriel Flores, Juan C Vicenty, Emil A Pastrana
INTRODUCTION: There are limited data with regards to the associated risk of post-operative seizures in patients with surgically treated chronic subdural hematomas (CSDHs). The use of anti-epileptic drugs (AEDs) is associated with significant side effects. METHODS: A retrospective chart review was performed on patients operated via burr hole for CSDH in our institution from 2004 to 2013. Post-operative seizures at 1-year follow-up were identified. Demographic data, medical history, and imaging characteristics were recorded...
November 2017: Acta Neurochirurgica
Gregory S Doran, Ralph Deans, Carlo De Filippis, Chris Kostakis, Julia A Howitt
Police officers responsible for the seizure and removal of illegally grown cannabis plants from indoor and outdoor growing operations face the prospect of THC exposure while performing their work duties. As a result, a study investigating the amount of THC on hands and uniforms of officers during raids on cannabis growing houses (CGHs) and forest cannabis plantations (FCPs) and in the air at these sites was conducted. Swabs of gloves/hands, chests, and heads/necks were collected and analysed for THC. Results of hand swabs indicated that officers removing plants from FCPs were exposed to THC concentrations up to 20 times those involved in raids at CGHs, which was mainly associated with the number and size of plants seized...
June 2017: Forensic Science International
M Loveday, H Cox
No abstract text is available yet for this article.
February 27, 2017: South African Medical Journal, Suid-Afrikaanse Tydskrif Vir Geneeskunde
Susan L Garber
Every day, in clinics and hospitals around the world, occupational therapists care for patients with serious problems requiring viable solutions. Each patient is unique, and his or her problem does not necessarily correspond to existing practice models. Practitioners must adapt standard approaches to provide effective outcomes, yet problems exist for which few or no beneficial approaches have been identified. Such clinical issues require solutions to be generated de novo from the practitioner's body of knowledge and past experience...
November 2016: American Journal of Occupational Therapy: Official Publication of the American Occupational Therapy Association
Sofia-Ioanna Tseferidi, Fay Griva, Fotios Anagnostopoulos
The present study examined associations of time perspective (TP) with indicators of well-being including satisfaction with life, anxiety and depression, after controlling for sociodemographic factors. Adult participants (N = 413) completed a web-based questionnaire that included a short version of the Zimbardo Time Perspective Inventory, the State-Trait Anxiety Inventory, and the Center for Epidemiologic Studies-Depression Scale. Life satisfaction was more strongly associated with the present hedonistic dimension, suggesting that the tendency to take risks and to fulfil one's desires may lead to experiencing pleasure in a 'seize the day' approach to life...
June 2017: Psychology, Health & Medicine
Pamela Cabarcos, Paloma Herbello-Hermelo, Iván Álvarez-Freire, Antonio Moreda-Piñeiro, María Jesús Tabernero, Ana María Bermejo, Pilar Bermejo-Barrera
A simple sample pre-treatment method based on solid phase microextraction (SPME) and gas chromatography-mass spectrometry (GC-MS) has been optimized and validated for the assessment of 15 residual solvents (2-propanol, 2-methylpentane, 3-methylpentane, acetone, ethyl acetate, benzene, hexane, methylcyclohexane, methylcyclopentane, m-xylene, propyl acetate, toluene, 1,2,4-trimethylbenzene, dichloromethane, and ethylbenzene) in seized illicit cocaine and heroin. DMSO and DMF as sample diluents were found to offer the best residual solvent transference to the head space for further adsorption onto the SPME fiber, and the developed method therefore showed high sensitivity and analytical recovery...
September 2016: Analytical and Bioanalytical Chemistry
Walid Albanna, Catharina Conzen, Miriam Weiss, Hans Clusmann, Matthias Fuest, Marguerite Mueller, Marc Alexander Brockmann, Walthard Vilser, Arno Schmidt-Trucksäss, Anke Hoellig, Marcel Seiz, Claudius Thomé, Konstantin Kotliar, Gerrit Alexander Schubert
BACKGROUND: Timely detection of impending delayed cerebral ischemia after subarachnoid hemorrhage (SAH) is essential to improve outcome, but poses a diagnostic challenge. Retinal vessels as an embryological part of the intracranial vasculature are easily accessible for analysis and may hold the key to a new and non-invasive monitoring technique. This investigation aims to determine the feasibility of standardized retinal vessel analysis (RVA) in the context of SAH. METHODS: In a prospective pilot study, we performed RVA in six patients awake and cooperative with SAH in the acute phase (day 2-14) and eight patients at the time of follow-up (mean 4...
2016: PloS One
Suzanne Martin Stricklin
BACKGROUND: Twenty-five percent of American adults experience a diagnosable psychiatric mental health (PMH) problem each year, and acute care medical-surgical nurses carry on average a five- to six-patient load per shift. Traditionally, U.S. PMH clinical experiences have occurred on inpatient units located within acute care hospitals or psychiatric hospital settings. However, many nursing programs are moving much of the PMH clinical experience to community-based settings. OBJECTIVES: This study aims to investigate how prelicensure undergraduate baccalaureate (BSN) student nurses and their faculty perceive students' ability to achieve learning outcomes in community-based PMH clinical settings...
July 2016: Journal of the American Psychiatric Nurses Association
Anne C Ritter, Candace M Kammerer, Maria M Brooks, Yvette P Conley, Amy K Wagner
OBJECTIVE: Posttraumatic seizures (PTS) commonly occur following severe traumatic brain injury (sTBI). Risk factors for PTS have been identified, but variability in who develops PTS remains. Excitotoxicity may influence epileptogenesis following sTBI. Glutamate transporters manage glutamate levels and excitatory neurotransmission, and they have been associated with both epilepsy and TBI. Therefore, we aimed to determine if genetic variation in neuronal glutamate transporter genes is associated with accelerated epileptogenesis and increased PTS risk after sTBI...
June 2016: Epilepsia
Veniero Gambaro, Gabriella Roda, Giacomo Luca Visconti, Sebastiano Arnoldi, Eleonora Casagni, Lucia Dell'Acqua, Fiorenza Farè, Eleonora Paladino, Chiara Rusconi, Stefania Arioli, Diego Mora
The taxonomic identification of the biological material contained in the hallucinogenic mushrooms culture media, was carried out using a DNA-based approach, thus highlighting the usefulness of this approach in the forensic identification of illegal samples also when they are present as basidiospores mixed in culture media and spore-bearing fruiting body are not present. This approach is very useful as it allows the unequivocal identification of potentially illicit material before the cultivation and it enables to stop the material to the Customs and to destroy it due to its dangerousness without cultivating the "grow-kits" and without instructing a criminal case...
June 5, 2016: Journal of Pharmaceutical and Biomedical Analysis
John W Williams, Gary Maslow
No abstract text is available yet for this article.
March 1, 2016: Annals of Internal Medicine
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