Sarah-Naomi James, Emily N Manning, Mathew Storey, Jennifer M Nicholas, William Coath, Sarah E Keuss, David M Cash, Christopher A Lane, Thomas Parker, Ashvini Keshavan, Sarah M Buchanan, Aaron Wagen, Mathew Harris, Ian Malone, Kirsty Lu, Louisa P Needham, Rebecca Street, David Thomas, John Dickson, Heidi Murray-Smith, Andrew Wong, Tamar Freiberger, Sebastian J Crutch, Nick C Fox, Marcus Richards, Frederik Barkhof, Carole H Sudre, Josephine Barnes, Jonathan M Schott
We investigate associations between normal-appearing white matter microstructural integrity in cognitively normal ∼70-year-olds and concurrently measured brain health and cognition, demographics, genetics and life course cardiovascular health. Participants born in the same week in March 1946 (British 1946 birth cohort) underwent PET-MRI around age 70. Mean standardized normal-appearing white matter integrity metrics (fractional anisotropy, mean diffusivity, neurite density index and orientation dispersion index) were derived from diffusion MRI...
2023: Brain communications