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https://www.readbyqxmd.com/read/28334007/a-functional-variant-in-neph3-gene-confers-high-risk-of-renal-failure-in-primary-hematuric-glomerulopathies-evidence-for-predisposition-to-microalbuminuria-in-the-general-population
#1
Konstantinos Voskarides, Charalambos Stefanou, Myrtani Pieri, Panayiota Demosthenous, Kyriakos Felekkis, Maria Arsali, Yiannis Athanasiou, Dimitris Xydakis, Kostas Stylianou, Eugenios Daphnis, Giorgos Goulielmos, Petros Loizou, Judith Savige, Martin Höhne, Linus A Völker, Thomas Benzing, Patrick H Maxwell, Daniel P Gale, Mathias Gorski, Carsten Böger, Barbara Kollerits, Florian Kronenberg, Bernhard Paulweber, Michalis Zavros, Alkis Pierides, Constantinos Deltas
BACKGROUND: Recent data emphasize that thin basement membrane nephropathy (TBMN) should not be viewed as a form of benign familial hematuria since chronic renal failure (CRF) and even end-stage renal disease (ESRD), is a possible development for a subset of patients on long-term follow-up, through the onset of focal and segmental glomerulosclerosis (FSGS). We hypothesize that genetic modifiers may explain this variability of symptoms. METHODS: We looked in silico for potentially deleterious functional SNPs, using very strict criteria, in all the genes significantly expressed in the slit diaphragm (SD)...
2017: PloS One
https://www.readbyqxmd.com/read/28323826/apoe-related-risk-of-mild-cognitive-impairment-and-dementia-for-prevention-trials-an-analysis-of-four-cohorts
#2
Jing Qian, Frank J Wolters, Alexa Beiser, Mary Haan, M Arfan Ikram, Jason Karlawish, Jessica B Langbaum, John M Neuhaus, Eric M Reiman, J Scott Roberts, Sudha Seshadri, Pierre N Tariot, Beth McCarty Woods, Rebecca A Betensky, Deborah Blacker
BACKGROUND: With the onset of prevention trials for individuals at high risk for Alzheimer disease, there is increasing need for accurate risk prediction to inform study design and enrollment, but available risk estimates are limited. We developed risk estimates for the incidence of mild cognitive impairment (MCI) or dementia among cognitively unimpaired individuals by APOE-e4 dose for the genetic disclosure process of the Alzheimer's Prevention Initiative Generation Study, a prevention trial in cognitively unimpaired APOE-e4/e4 homozygote individuals...
March 2017: PLoS Medicine
https://www.readbyqxmd.com/read/28302271/risk-stratification-model-for-30-day-heart-failure-readmission-in-a-multiethnic-south-east-asian-community
#3
Kui Toh Gerard Leong, Lai Yin Wong, Khin Chaw Yu Aung, Michael Macdonald, Yan Cao, Sheldon Lee, Wai Leng Chow, Sanjay Doddamani, Arthur Mark Richards
There are limited accurate 30-day heart failure (HF) readmission risk scores using readily available clinical patient information on a well-defined HF cohort. We analyzed 1,475 admissions discharged from our hospital with a primary diagnosis of HF between 2010 and 2012. HF diagnostic criteria included satisfying clinical Framingham criteria, elevated serum N-terminal pro-natriuretic peptide, and evidence of cardiac dysfunction on transthoracic echocardiography. The patients were randomly divided into 2 groups; 60% were used as the derivation cohort and 40% as the validation cohort...
February 10, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/28293452/prevalence-of-metabolic-syndrome-and-degree-of-cardiovascular-disease-risk-in-patients-with-psoriatic-arthritis
#4
Sıdıka Gülkan Özkan, Hatice Yazısız, Ahmet Behlül, Yüksel Aslı Gökbelen, Fatih Borlu, Veli Yazısız
OBJECTIVE: The aim of this study was to identify the prevalence of metabolic syndrome (MetS) and degree of cardiovascular disease (CVD) risk in patients with psoriatic arthritis (PsA). MATERIAL AND METHODS: We performed a cross-sectional study on 102 adult patients with PsA and a control group of 102 patients with rheumatoid arthritis (RA). MetS was diagnosed according to the National Cholesterol Education Program Adult Treatment Panel III (NCEP-ATP III) and International Diabetes Federation (IDF) criteria...
March 2017: European Journal of Rheumatology
https://www.readbyqxmd.com/read/28275071/relations-of-metabolically-healthy-and-unhealthy-obesity-to-digital-vascular-function-in-three-community-based-cohorts-a-meta-analysis
#5
REVIEW
Luisa C C Brant, Na Wang, Francisco M Ojeda, Michael LaValley, Sandhi M Barreto, Emelia J Benjamin, Gary F Mitchell, Ramachandran S Vasan, Joseph N Palmisano, Thomas Münzel, Stefan Blankenberg, Philipp S Wild, Tanja Zeller, Antonio L P Ribeiro, Renate B Schnabel, Naomi M Hamburg
BACKGROUND: Microvascular dysfunction is a marker of early vascular disease that predicts cardiovascular events. Whether metabolically healthy obese individuals have impaired microvascular function remains unclear. The aim of this study was to evaluate the relation of obesity phenotypes stratified by metabolic status to microvascular function. METHODS AND RESULTS: We meta-analyzed aggregate data from 3 large cohorts (Brazilian Longitudinal Study of Adult Health, the Framingham Heart Study, and the Gutenberg Heart Study; n=16 830 participants, age range 19-90, 51...
March 8, 2017: Journal of the American Heart Association
https://www.readbyqxmd.com/read/28257604/the-metabolic-syndrome-its-components-and-knee-osteoarthritis-oa-the-framingham-oa-study
#6
Jingbo Niu, Margaret Clancy, Piran Aliabadi, Vasan Ramachandran, David T Felson
OBJECTIVES: Studies have suggested that Metabolic Syndrome (MetS) is associated with osteoarthritis (OA). However, analyses have often not adjusted for BMI and have not explored whether levels of individual MetS components are related to OA. METHODS: Framingham Study subjects were assessed for OA in 1992-95 and again in 2002-05. Near the baseline visit, subjects had components of the MetS assessed. We defined incident radiographic OA (ROA) as present when a knee without ROA developed Kellgren and Lawrence grade ≥2 at follow-up and defined incident symptomatic OA (SxOA) as present when a knee developed the new combination of ROA and knee pain...
March 3, 2017: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/28214752/metabolic-syndrome-and-cardiovascular-risk-among-institutionalized-patients-with-schizophrenia-receiving-long-term-tertiary-care
#7
Lee Seng Esmond Seow, Siow Ann Chong, Peizhi Wang, Saleha Shafie, Hui Lin Ong, Mythily Subramaniam
BACKGROUND: Metabolic syndrome (MetS) and cardiovascular risk are highly prevalent among individuals with schizophrenia. This study aimed to determine the cardiometabolic profile and the associated risk factors in a group of institutionalized patients with schizophrenia or schizoaffective disorder receiving prolonged hospital care in the only tertiary psychiatric institution in Singapore. METHODS: Patients residing in long stay wards who were hospitalized for a minimum period of 1year were recruited...
February 2, 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28150104/assessment-of-six-cardiovascular-risk-calculators-in-mexican-mestizo-patients-with-rheumatoid-arthritis-according-to-the-eular-2015-2016-recommendations-for-cardiovascular-risk-management
#8
Dionicio A Galarza-Delgado, Jose R Azpiri-Lopez, Iris J Colunga-Pedraza, Jesus A Cardenas-de la Garza, Raymundo Vera-Pineda, Griselda Serna-Peña, Rosa I Arvizu-Rivera, Adrian Martinez-Moreno, Martin Wah-Suarez, Mario A Garza Elizondo
Variability of the 10-year cardiovascular (CV) risk predicted by the Framingham Risk Score (FRS) using lipids, FRS using body mass index (BMI), Reynolds Risk Score (RRS), QRISK2, Extended Risk Score-Rheumatoid Arthritis (ERS-RA), and algorithm developed by the American College of Cardiology and the American Heart Association in 2013 (ACC/AHA 2013) according to the European League Against Rheumatism (EULAR) 2015/2016 update of its evidence-based recommendations for cardiovascular risk management in patients with rheumatoid arthritis (RA) has not been evaluated in Mexican mestizo patients...
February 1, 2017: Clinical Rheumatology
https://www.readbyqxmd.com/read/28125958/long-term-mortality-in-older-patients-discharged-after-acute-decompensated-heart-failure-a-prospective-cohort-study
#9
Pierre-André Natella, Philippe Le Corvoisier, Elena Paillaud, Bertrand Renaud, Isabelle Mahé, Jean-François Bergmann, Hervé Perchet, Dominique Mottier, Olivier Montagne, Sylvie Bastuji-Garin
BACKGROUND: Data are available on short- and intermediate-term mortality rates after discharge for acutely decompensated heart failure (ADHF). However, few studies specifically addressed ADHF outcomes in patients aged 75 years or over, who contribute more than half of all ADHF admissions. Our objectives here were to estimate the long-term mortality of patients aged 75 years or over who were discharged after admission for ADHF and to identify factors, especially geriatric findings, independently associated with 2-year mortality...
January 26, 2017: BMC Geriatrics
https://www.readbyqxmd.com/read/28087832/comparison-of-cardiovascular-risk-algorithms-in-patients-with-vs-without-rheumatoid-arthritis-and-the-role-of-c-reactive-protein-in-predicting-cardiovascular-outcomes-in-rheumatoid-arthritis
#10
Evo Alemao, Hélène Cawston, François Bourhis, Maiwenn Al, Maureen Rutten-van Molken, Katherine P Liao, Daniel H Solomon
OBJECTIVES: The aims were to compare the performance of cardiovascular risk calculators, Framingham Risk Score (FRS) and QRISK2, in RA and matched non-RA patients and to evaluate whether their performance could be enhanced by the addition of CRP. METHODS: We conducted a retrospective analysis, using a clinical practice data set linked to Hospital Episode Statistics (HES) data from the UK. Patients presenting with at least one RA diagnosis code and no prior cardiovascular events were matched to non-RA patients using disease risk scores...
January 12, 2017: Rheumatology
https://www.readbyqxmd.com/read/28062468/comparison-of-self-perceived-cardiovascular-disease-risk-among-smokers-with-framingham-and-procam-scores-a-cross-sectional-analysis-of-baseline-data-from-a-randomised-controlled-trial
#11
Benoît Desgraz, Tinh-Hai Collet, Nicolas Rodondi, Jacques Cornuz, Carole Clair
OBJECTIVES: Previous studies suggest that smokers have a misperception of their 10-year cardiovascular risk. We aimed to compare 10-year cardiovascular risk self-perception and calculated risk among smokers willing to quit and assess the determinants of a possible misperception. DESIGN: Cross-sectional secondary analysis of baseline data from a randomised controlled trial of smoking cessation. PARTICIPANTS: 514 participants, mean age 51.1 years, 46% women, 98% Caucasian...
January 6, 2017: BMJ Open
https://www.readbyqxmd.com/read/27977851/implementation-of-treatment-guidelines-for-specialist-mental-health-care
#12
REVIEW
Irene Bighelli, Giovanni Ostuzzi, Francesca Girlanda, Andrea Cipriani, Thomas Becker, Markus Koesters, Corrado Barbui
BACKGROUND: A huge gap exists between the production of evidence and its uptake in clinical practice settings. To fill this gap, treatment guidelines, based on explicit assessments of the evidence base, are commonly used in several fields of psychiatry, including schizophrenia and related psychotic disorders. However, it remains unclear whether treatment guidelines have any material impact on provider performance and patient outcomes, and how implementation should be conducted to maximise benefit...
December 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27955664/the-burden-of-hypertension-diabetes-mellitus-and-cardiovascular-risk-factors-among-adult-malawians-in-hiv-care-consequences-for-integrated-services
#13
Oscar H Divala, Alemayehu Amberbir, Zahra Ismail, Teferi Beyene, Daniela Garone, Colin Pfaff, Victor Singano, Harriet Akello, Martias Joshua, Moffat J Nyirenda, Alfred Matengeni, Josh Berman, Jane Mallewa, Gift S Chinomba, Noel Kayange, Theresa J Allain, Adrienne K Chan, Sumeet K Sodhi, Joep J van Oosterhout
BACKGROUND: Hypertension and diabetes prevalence is high in Africans. Data from HIV infected populations are limited, especially from Malawi. Integrating care for chronic non-communicable co-morbidities in well-established HIV services may provide benefit for patients by preventing multiple hospital visits but will increase the burden of care for busy HIV clinics. METHODS: Cross-sectional study of adults (≥18 years) at an urban and a rural HIV clinic in Zomba district, Malawi, during 2014...
December 12, 2016: BMC Public Health
https://www.readbyqxmd.com/read/27882006/framingham-risk-score-in-impaired-glucose-tolerant-population-a-sub-analysis-of-diabetes-prevention-and-awareness-program-of-pakistan
#14
Asher Fawwad, Hassan Moin, Iftikhar Ahmed Siddiqui, Muhammad Zafar Iqbal Hydrie, Abdul Basit
OBJECTIVE: To assess the 10-year risk of coronary artery disease (CAD) in subjects with impaired glucose tolerance (IGT) using Framingham risk score. METHODS: Data for this study was collected from Diabetes Prevention and Awareness Program. Primary prevention team visited different primary health care centers, factories, service organizations and offices within Karachi, Pakistan. IGT was diagnosed according to World Health Organization criteria after taking informed consent...
September 2016: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/27857821/carotid-artery-atherosclerosis-in-patients-with-active-rheumatoid-arthritis-predictors-of-plaque-occurrence-and-progression-over-24-weeks
#15
Janet E Pope, Tatiana Nevskaya, Lillian Barra, Grace Parraga
INTRODUCTION: This study evaluated the prevalence and progression of subclinical carotid artery atherosclerosis in active rheumatoid arthritis (RA). METHODS: Carotid arteries of RA patients were scanned using 3D ultrasound at baseline and 24 weeks for total plaque area, vessel wall volume, and intima-media thickness (IMT), as well as arterial stiffness measured using pulse wave velocity. Variables related to inflammation, lipids and cardiovascular (CV) risk were assessed for associations with plaque progression...
2016: Open Rheumatology Journal
https://www.readbyqxmd.com/read/27813300/echocardiographic-screening-for-non-ischaemic-stage-b-heart-failure-in-the-community
#16
Hong Yang, Kazuaki Negishi, Ying Wang, Mark Nolan, Makoto Saito, Thomas H Marwick
AIMS: Incident heart failure (HF) continues to pose a common and serious problem. We sought to examine the value of echocardiographic predictors of new HF in a community-based elderly population at risk for HF, independent of and incremental to clinical evaluation. METHODS AND RESULTS: Asymptomatic patients ≥65 years old, with ≥1 HF risk factor (hypertension, type 2 diabetes, or obesity) were recruited from the community; patients with valve disease, reduced ejection fraction (EF), and atrial fibrillation (AF) were excluded...
November 2016: European Journal of Heart Failure
https://www.readbyqxmd.com/read/27776389/arterial-stiffness-in-patients-taking-second-generation-antipsychotics
#17
Ebru Fındıklı, Mustafa Gökçe, Vedat Nacitarhan, Mehmet Akif Camkurt, Hüseyin Avni Fındıklı, Selçuk Kardaş, Merve Coşgun Şahin, Mehmet Fatih Karaaslan
Objective: That treatment with second-generation antipsychotics (SGAs) causes metabolic side effects and atherosclerosis in patients with schizophrenia and bipolar disorder (BD) is well-known. Increased arterial stiffness is an important marker of arteriosclerosis and has been identified as an independent risk factor for cardiovascular diseases. We measured pulse wave velocity (PWV) as a marker of arteriosclerosis in patients with schizophrenia and BD who use SGAs. Methods: Patients and controls were collected from our psychiatry outpatient clinics or family medicine...
November 30, 2016: Clinical Psychopharmacology and Neuroscience: the Official Scientific Journal of the Korean College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/27757680/evaluation-of-a-new-approach-to-compute-intervertebral-disc-height-measurements-from-lateral-radiographic-views-of-the-spine
#18
Brett T Allaire, M Clara DePaolis Kaluza, Alexander G Bruno, Elizabeth J Samelson, Douglas P Kiel, Dennis E Anderson, Mary L Bouxsein
PURPOSE: Current standard methods to quantify disc height, namely distortion compensated Roentgen analysis (DCRA), have been mostly utilized in the lumbar and cervical spine and have strict exclusion criteria. Specifically, discs adjacent to a vertebral fracture are excluded from measurement, thus limiting the use of DCRA in studies that include older populations with a high prevalence of vertebral fractures. Thus, we developed and tested a modified DCRA algorithm that does not depend on vertebral shape...
January 2017: European Spine Journal
https://www.readbyqxmd.com/read/27754006/js-ish-esh-2-update-on-the-detection-and-follow-up-of-early-hypertensive-heart-disease
#19
Enrico Agabiti Rosei
Current Hypertension Guidelines emphasize the importance of assessing the presence of preclinical organ damage. In fact, an extensive evaluation of organ damage may increase the number of patients classified at high CV risk and therefore strongly influence the clinical management of patients. Hypertensive heart disease remains to date the form of organ damage for which there is the greatest amount of evidence of a strong independent prognostic significance. In the presence of a chronic pressure overload, a parallel addition of sarcomers takes place with an increase in myocyte width, which in turn increases left ventricular wall thickness; myocyte hypertrophy is also associated with apoptosis, collagen deposition and ventricular fibrosis with an impairment of coronary hemodynamics as well, thus profoundly influencing functional properties of the left (and right) ventricle...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27703569/heart-failure-predictors-in-a-group-of-patients-with-myocardial-infarction
#20
Sokol Myftiu, Petrit Bara, Ilir Sharka, Artan Shkoza, Xhina Belshi, Edlira Rruci, Gentian Vyshka
AIM: The present study considers of the prevalence of heart failure (HF) in patients suffering from acute myocardial infarction (AMI) in the University Hospital Centre of Tirana (UHCT) "Mother Theresa"; the demographic and clinical characteristics of the sample during hospitalization; and the main predictors of heart failure occurrence inside the group of patients suffering an AMI. MATERIAL AND METHODS: During a period of study from 2013-2015 we studied demographic and clinical data from 587 consecutive patients presenting with AMI; Framingham criteria were adopted for classifying patients with HF upon admission...
September 15, 2016: Open Access Macedonian Journal of Medical Sciences
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