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TM rupture

Ross S Gunderson, Aurelia R Honerkamp-Smith
Membranes made from certain ternary mixtures of lipids can display coexisting liquid phases. In giant unilamellar vesicles, these phases appear as liquid domains which diffuse and coalesce after the vesicle is cooled below its miscibility transition temperature (Tm ). Converting vesicles to supported lipid bilayers alters the mobility of the lipids and domains in the bilayer. At the same time, the miscibility transition temperature (Tm ) of the lipid mixture is altered. Here we compare Tm in vesicles and in supported bilayers formed by rupturing the same vesicles onto glass...
May 9, 2018: Biochimica et Biophysica Acta
Chunmei Li, Nanpu Cheng, Zhiqian Chen, Zhongjing Xie, Liangliang Hui
Al₃TM(TM = Ti, Zr, Hf, Sc) particles acting as effective grain refiners for Al alloys have been receiving extensive attention these days. In order to judge their nucleation behaviors, first-principles calculations are used to investigate their intermetallic and interfacial properties. Based on energy analysis, Al₃Zr and Al₃Sc are more suitable for use as grain refiners than the other two intermetallic compounds. Interfacial properties show that Al/Al₃TM(TM = Ti, Zr, Hf, Sc) interfaces in I-ter interfacial mode exhibit better interface wetting effects due to larger Griffith rupture work and a smaller interface energy...
April 20, 2018: Materials
Irene Isabel López-Torres, Pablo Sanz-Ruíz, Coral Sánchez-Pérez, Ricardo Andrade-Albarracín, Javier Vaquero
INTRODUCTION: Acetabular revision surgery poses a challenge due to the increased frequency of severe defects and poor quality of the remaining bone. We compare the clinical and radiological outcomes, complications, and survival of two systems commonly used in complex acetabular revisions (AAOS types II, III, and IV): trabecular metal system (TM) and Burch-Schneider antiprotrusion cages (BS). METHODS: Eighty-four patients underwent acetabular revision surgery with TM or BS in our centre between 2008 and 2014...
February 26, 2018: International Orthopaedics
Alex M Witek, Nina Z Moore, M Adeeb Sebai, Mark D Bain
BACKGROUND: Although tubular retractor systems have gained popularity for other indications, there have been few reports of their use for arteriovenous malformation (AVM) surgery. A patient was diagnosed with a ruptured 1.2-cm subcortical AVM after presenting with intracerebral hemorrhage in the right frontal lobe and anterior basal ganglia. The characteristics of this AVM made it amenable to resection using a tubular retractor. OBJECTIVE: To demonstrate the feasibility and safety of AVM resection using a tubular retractor system...
August 16, 2017: Operative Neurosurgery (Hagerstown, Md.)
Junfeng Liang, Zachery A Yokell, Don U Nakmaili, Rong Z Gan, Hongbing Lu
The rupture of tympanic membrane (TM) has long been viewed as an indicator of blast injury, especially for hearing loss. However, little is known about damage to the TM caused by blast with pressure lower than the rupture threshold. In this paper, we present our study on the effect of blast overpressure on the static mechanical properties of TM. Chinchilla was used as the animal model and exposed to multiple blasts with pressures lower than the rupture threshold of the TM. Using a micro-fringe projection method, we observed the alteration of the static mechanical properties of post-blast chinchilla's TMs as compared to those of control TMs...
August 18, 2017: Hearing Research
Muhammad Shuja Khan, Noura Sayed Dosoky, Darayas Patel, Jeffrey Weimer, John Dalton Williams
Supported lipid bilayers (SLBs) are widely used in biophysical research to probe the functionality of biological membranes and to provide diagnoses in high throughput drug screening. Formation of SLBs at below phase transition temperature (Tm) has applications in nano-medicine research where low temperature profiles are required. Herein, we report the successful production of SLBs at above-as well as below-the Tm of the lipids in an anisotropically etched, silicon-based micro-cavity. The Si-based cavity walls exhibit controlled temperature which assist in the quick and stable formation of lipid bilayer membranes...
July 5, 2017: Biosensors
Warren G Engles, Xuelin Wang, Rong Z Gan
Blast overpressure causes dynamic damage to middle ear components, and tympanic membrane (TM) rupture is the most frequent middle ear injury. However, it is unclear how the blast waves change mechanical properties of the TM and affect sound transmission through the ear. This paper reports the current study on dynamic properties of the TM after exposure to blast waves by using acoustic loading and laser Doppler vibrometry (LDV). The TM specimens were prepared from human temporal bones following exposures to blast overpressure...
October 2017: Annals of Biomedical Engineering
Juni Banerjee, Chi-Ting Leung, Ang Li, Kim Peterson-Yantorno, Huan Ouyang, W Daniel Stamer, Mortimer M Civan
Purpose: Trabecular meshwork (TM) cell volume is a determinant of aqueous humor outflow resistance, and thereby IOP. Regulation of TM cell volume depends on chloride ion (Cl-) release through swelling-activated channels (ICl,Swell), whose pore is formed by LRRC8 proteins. Chloride ion release through swelling-activated channels has been reported to be regulated by calcium-activated anoctamins, but this finding is controversial. Particularly uncertain has been the effect of anoctamin Ano6, reported as a Ca2+-activated Cl- (CaCC) or cation channel in other cells...
January 1, 2017: Investigative Ophthalmology & Visual Science
Jian Liu, Yisen Zhang, Yang Wang, Shiqing Mu, Xinjian Yang
BACKGROUND: Ruptured intracranial fusiform aneurysms involving small-diameter parent arteries are difficult to treat. Parent artery occlusion is a relatively simple and reliable treatment. However, occasionally, the parent arteries have to be retained. The arrival of the low-profile stent (LVIS Jr.) has made reconstructive endovascular treatment for fusiform aneurysms involving small-diameter parent arteries possible. CASE DESCRIPTION: This report describes an innovative method for stent-assisted coiling (stenting after coiling technique using only 1 microcatheter) and describes our initial experience and feasibility of this technique...
March 2017: World Neurosurgery
Kazuaki Mineta, Naoto Suzue, Tetsuya Matsuura, Koichi Sairyo
Here, we report the efficacy of the suture bridge technique for treating insertional Achilles tendinosis in an obese and athletic patient. A 48-year-old man presented to our department with a 6-month history of left posterior heel pain. The patient was an athlete (triathlon) and appeared obese (height: 197 cm, body weight: 120 kg, body mass index: 30.9). A diagnosis of insertional Achilles tendinosis was made. Because 6 months of conservative treatments had failed, we performed open resection of the calcaneal exostosis and Haglund's deformity along with debridement of the degenerative tissue of the tendon...
2016: Journal of Medical Investigation: JMI
(no author information available yet)
Svoboda SJ, Owens BD, Harvey TM, Tarwater PM, Brechue WF, Cameron KL. The association between serum biomarkers of collagen turnover and subsequent anterior cruciate ligament rupture. Am J Sports Med 2016;44(7):1687-1693. (Original DOI: 10.1177/0363546516640515)In the above article, the affiliation for Travis M. Harvey was incorrectly listed. The correct affiliation is United States Special Operations Command, MacDill Air Force Base, Florida, USA.
September 2016: American Journal of Sports Medicine
Rong Z Gan, Don Nakmali, Xiao D Ji, Kegan Leckness, Zachary Yokell
Mechanical damage to middle ear components in blast exposure directly causes hearing loss, and the rupture of the tympanic membrane (TM) is the most frequent injury of the ear. However, it is unclear how the severity of injury graded by different patterns of TM rupture is related to the overpressure waveforms induced by blast waves. In the present study, the relationship between the TM rupture threshold and the impulse or overpressure waveform has been investigated in chinchillas. Two groups of animals were exposed to blast overpressure simulated in our lab under two conditions: open field and shielded with a stainless steel cup covering the animal head...
October 2016: Hearing Research
A Merini, A Viste, R Desmarchelier, M-H Fessy
INTRODUCTION: Implant neck fracture involving a non-modular femoral stem is rare in primary total hip arthroplasty (THA). Occasional cases have been reported following laser etching of the Corail(tm) stem, but risk factors have not been precisely determined. We therefore performed a retrospective study on a series of Corail(tm) stems with laser neck etching, in order to: (1) determine the exact implant neck fracture rate at 10 years, and (2) identify associated risk factors. HYPOTHESIS: Laser etching increases the rate of implant neck fracture...
February 2016: Orthopaedics & Traumatology, Surgery & Research: OTSR
Cho Ee Ng, Andrew Pieri, Tarannum Fasih
BACKGROUND: Acellular dermal matrices (ADM) such as Strattice(TM) are increasingly used in UK during implant-based reconstruction. However, there are mixed opinions regarding the compatibility of radiotherapy treatment in pre- and post-reconstructed breasts. The aims of this study are to audit the rates of radiation induced complications in patients who underwent breast reconstruction using Strattice(TM) and establish whether there is an association between timing of radiotherapy and complication rates...
2015: European Journal of Plastic Surgery
Meijuan Ma, Liqiang Song, Hao Yan, Min Liu, Le Zhang, Ying Ma, Jian Yuan, Jianhua Hu, Zhaole Ji, Rongqing Zhang, Congye Li, Haichang Wang, Ling Tao, Yingmei Zhang, Yan Li
After decades of indolent progression, atherosclerosis may cause unheralded events, such as myocardial infarction, acute coronary syndrome and stroke due to sudden rupture of atherosclerotic plaques, and pharmacologically modulating plaque stability would reduce the risk of cardiovascular diseases. Endoplasmic reticulum stress (ERS) is responsible for the vulnerability of plaques. However, the underlying mechanism has not been fully elucidated. In this work, ApoE(-/-) mice underwent perivascular carotid collar placement surgeries or sham operations were given higher (3...
January 15, 2016: Biochemical Pharmacology
Olaposi I Omotuyi, Jun Nagai, Hiroshi Ueda
Lysophosphatidic acid (LPA) receptor 1 (LPA1) is a member of the G protein-coupled receptors mediating the biological response to LPA species. Lack of detailed mechanism underlying LPA/LPA1 interaction has hampered the development of specific antagonists. Here, novel N-terminal Lys39 has been identified as a key residue during LPA-type agonist binding and LPA1 activation. Analysis of the molecular dynamics (MD) trajectories showed that LPA-type agonist but not VPC-32183 (antagonist) evolved structures with classical GPCR activation signatures such as reduced cytoplasmic transmembrane (TM) 3/TM6 dynamic network, ruptured ionic lock, and formation of a continuous and highly ordered internal water pathway was also observed...
August 13, 2015: Scientific Reports
Donghai Wang, Ying Wang, Wandong Su, Yunyan Wang, Gang Li, Xingang Li
To describe our initial experience and early outcomes with distal placement of the Neuron 6F guiding catheter through coiled ICA for aneurysmal EVT. We examined the utility of the Neuronf 70 6F guiding catheter for the embolization procedure in such cases, fourteen cases of aneurysm with coiling of the parent ICA are presented via traditional guiding catheters. With the support of 8F ENVOY guiding catheter as a shuttle sheath, the Neuron(TM) 70 6F guiding catheter was successfully placed through coiled extracranial ICA, so the mirocatheter could be delivered to a more strategic position for embolization of the aneurysm...
2015: International Journal of Clinical and Experimental Medicine
Siobhan A O'Leary, Donagh A Healey, Eamon G Kavanagh, Michael T Walsh, Tim M McGloughlin, Barry J Doyle
Rupture of the abdominal aortic aneurysm (AAA) occurs when the local wall stress exceeds the local wall strength. Knowledge of AAA wall mechanics plays a fundamental role in the development and advancement of AAA rupture risk assessment tools. Therefore, the aim of this study is to evaluate the biaxial mechanical properties of AAA tissue. Multiple biaxial test protocols were performed on AAA samples harvested from 28 patients undergoing open surgical repair. Both the Tangential Modulus (TM) and stretch ratio (λ) were recorded and compared in both the circumferential (ϴ) and longitudinal (L) directions at physiologically relevant stress levels, the influence of patient specific factors such as sex, age AAA diameter and status were examined...
December 2014: Annals of Biomedical Engineering
Yujia Jing, Hana Trefna, Mikael Persson, Bengt Kasemo, Sofia Svedhem
DPPC liposomes ranging from 90 nm to 160 nm in diameter were prepared and used for studies of the formation of supported lipid membranes on silica (SiO2) at temperatures below and above the gel to liquid-crystalline phase transition temperature (Tm = 41 °C), and by applying temperature gradients through Tm. The main method was the quartz crystal microbalance with dissipation (QCM-D) technique. It was found that liposomes smaller than 100 nm spontaneously rupture on the silica surface when deposited at a temperature above Tm and at a critical surface coverage, following a well-established pathway...
January 7, 2014: Soft Matter
Elvira Og van Vliet, Ewoud Schuit, Karst Y Heida, Brent C Opmeer, Marjolein Kok, Wilfried Gyselaers, Martina M Porath, Mallory Woiski, Caroline J Bax, Kitty Wm Bloemenkamp, Hubertina Cj Scheepers, Yves Jaquemyn, Erik van Beek, Hans Jj Duvekot, Maureen Tm Franssen, Bas N Bijvank, Joke H Kok, Arie Franx, Ben Willem J Mol, Martijn A Oudijk
BACKGROUND: Preterm birth is the most common cause of neonatal morbidity and mortality. Postponing delivery for 48 hours with tocolytics to allow for maternal steroid administration and antenatal transportation to a centre with neonatal intensive care unit facilities is the standard treatment for women with threatening preterm delivery in most centres. However, there is controversy as to which tocolytic agent is the drug of first choice. Previous trials have focused on tocolytic efficacy and side effects, and are probably underpowered to detect clinically meaningfull differences in neonatal outcome...
March 3, 2014: BMC Pregnancy and Childbirth
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