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JOURNAL ARTICLE
Samira Musa Sasi, Nagia Musa Alghoul, Nuri Awayn, Ahmed Elghoul
Background: Dimethoate (DM) is one of the most organophosphorus pesticides used all over the world to control insect pests, the extensive use of this insecticide causes a health hazard to animals and humans. Aim: This study was conducted to evaluate the positive effect of green tea extract on sperm quality and testicular cytoarchitecture in male mice treated with DM and on its reproductive performance. Methods: Mice were divided into three groups, each group contained nine mice, the first group (control) was given distilled water only, the second group received DM at a dose (0...
March 2022: Open Veterinary Journal
#22
JOURNAL ARTICLE
Heng Yang, Junsik Sung, Zahra Alghoul, Didier Merlin
Oral administration of colon-targeting nanoformulations holds many advantages over the systemic delivery of free drugs, or traditional nontargeting formulations in the treatment of ulcerative colitis (UC). Currently, the most conventional method for constructing colon-targeting drug delivery systems (DDS) is by integrating the biocompatible materials poly(lactic-co-glycolic acid) (PLGA) and polylactic acid (PLA) into a copolymer. This PLGA/PLA-polyethylene glycol-folic acid (PEG-FA) copolymeric nanoformulation effectively delivers the drugs for uptake by various human colon cancer cells ( e...
April 5, 2022: Bio-protocol
#23
REVIEW
Lana Yh Lai, Faaizah Arshad, Carlos Areia, Thamir M Alshammari, Heba Alghoul, Paula Casajust, Xintong Li, Dalia Dawoud, Fredrik Nyberg, Nicole Pratt, George Hripcsak, Marc A Suchard, Dani Prieto-Alhambra, Patrick Ryan, Martijn J Schuemie
Post-marketing vaccine safety surveillance aims to detect adverse events following immunization in a population. Whether certain methods of surveillance are more precise and unbiased in generating safety signals is unclear. Here, we synthesized information from existing literature to provide an overview of the strengths, weaknesses, and clinical applications of epidemiologic and analytical methods used in vaccine monitoring, focusing on cohort, case-control and self-controlled designs. These designs are proposed to be evaluated in the EUMAEUS (Evaluating Use of Methods for Adverse Event Under Surveillance-for vaccines) study because of their widespread use and potential utility...
2022: Frontiers in Pharmacology
#24
JOURNAL ARTICLE
Kristin Kostka, Talita Duarte-Salles, Albert Prats-Uribe, Anthony G Sena, Andrea Pistillo, Sara Khalid, Lana Y H Lai, Asieh Golozar, Thamir M Alshammari, Dalia M Dawoud, Fredrik Nyberg, Adam B Wilcox, Alan Andryc, Andrew Williams, Anna Ostropolets, Carlos Areia, Chi Young Jung, Christopher A Harle, Christian G Reich, Clair Blacketer, Daniel R Morales, David A Dorr, Edward Burn, Elena Roel, Eng Hooi Tan, Evan Minty, Frank DeFalco, Gabriel de Maeztu, Gigi Lipori, Hiba Alghoul, Hong Zhu, Jason A Thomas, Jiang Bian, Jimyung Park, Jordi Martínez Roldán, Jose D Posada, Juan M Banda, Juan P Horcajada, Julianna Kohler, Karishma Shah, Karthik Natarajan, Kristine E Lynch, Li Liu, Lisa M Schilling, Martina Recalde, Matthew Spotnitz, Mengchun Gong, Michael E Matheny, Neus Valveny, Nicole G Weiskopf, Nigam Shah, Osaid Alser, Paula Casajust, Rae Woong Park, Robert Schuff, Sarah Seager, Scott L DuVall, Seng Chan You, Seokyoung Song, Sergio Fernández-Bertolín, Stephen Fortin, Tanja Magoc, Thomas Falconer, Vignesh Subbian, Vojtech Huser, Waheed-Ul-Rahman Ahmed, William Carter, Yin Guan, Yankuic Galvan, Xing He, Peter R Rijnbeek, George Hripcsak, Patrick B Ryan, Marc A Suchard, Daniel Prieto-Alhambra
Purpose: Routinely collected real world data (RWD) have great utility in aiding the novel coronavirus disease (COVID-19) pandemic response. Here we present the international Observational Health Data Sciences and Informatics (OHDSI) Characterizing Health Associated Risks and Your Baseline Disease In SARS-COV-2 (CHARYBDIS) framework for standardisation and analysis of COVID-19 RWD. Patients and Methods: We conducted a descriptive retrospective database study using a federated network of data partners in the United States, Europe (the Netherlands, Spain, the UK, Germany, France and Italy) and Asia (South Korea and China)...
2022: Clinical Epidemiology
#25
JOURNAL ARTICLE
Daniel R Morales, Anna Ostropolets, Lana Lai, Anthony Sena, Scott Duvall, Marc Suchard, Katia Verhamme, Peter Rjinbeek, Joe Posada, Waheed Ahmed, Thamer Alshammary, Heba Alghoul, Osaid Alser, Carlos Areia, Clair Blacketer, Edward Burn, Paula Casajust, Seng Chan You, Dalia Dawoud, Asieh Golozar, Menchung Gong, Jitendra Jonnagaddala, Kristine Lynch, Michael Matheny, Evan Minty, Fredrik Nyberg, Albert Uribe, Martina Recalde, Christian Reich, Martijn Scheumie, Karishma Shah, Nigam Shah, Lisa Schilling, David Vizcaya, Lin Zhang, George Hripcsak, Patrick Ryan, Daniel Prieto-Alhambra, Talita Durate-Salles, Kristin Kostka
Objective: Large international comparisons describing the clinical characteristics of patients with COVID-19 are limited. The aim of the study was to perform a large-scale descriptive characterization of COVID-19 patients with asthma. Methods: We included nine databases contributing data from January to June 2020 from the US, South Korea (KR), Spain, UK and the Netherlands. We defined two cohorts of COVID-19 patients ('diagnosed' and 'hospitalized') based on COVID-19 disease codes. We followed patients from COVID-19 index date to 30 days or death...
January 2023: Journal of Asthma
#26
JOURNAL ARTICLE
Carlen Reyes, Andrea Pistillo, Sergio Fernández-Bertolín, Martina Recalde, Elena Roel, Diana Puente, Anthony G Sena, Clair Blacketer, Lana Lai, Thamir M Alshammari, Waheed-Ui-Rahman Ahmed, Osaid Alser, Heba Alghoul, Carlos Areia, Dalia Dawoud, Albert Prats-Uribe, Neus Valveny, Gabriel de Maeztu, Luisa Sorlí Redó, Jordi Martinez Roldan, Inmaculada Lopez Montesinos, Lisa M Schilling, Asieh Golozar, Christian Reich, Jose D Posada, Nigam Shah, Seng Chan You, Kristine E Lynch, Scott L DuVall, Michael E Matheny, Fredrik Nyberg, Anna Ostropolets, George Hripcsak, Peter R Rijnbeek, Marc A Suchard, Patrick Ryan, Kristin Kostka, Talita Duarte-Salles
OBJECTIVE: To characterise patients with and without prevalent hypertension and COVID-19 and to assess adverse outcomes in both inpatients and outpatients. DESIGN AND SETTING: This is a retrospective cohort study using 15 healthcare databases (primary and secondary electronic healthcare records, insurance and national claims data) from the USA, Europe and South Korea, standardised to the Observational Medical Outcomes Partnership common data model. Data were gathered from 1 March to 31 October 2020...
December 22, 2021: BMJ Open
#27
JOURNAL ARTICLE
Chunhua Yang, Dingpei Long, Junsik Sung, Zahra Alghoul, Didier Merlin
The past decade has seen increasing interest in microbiota-targeting therapeutic strategies that aim to modulate the gut microbiota's composition and/or function to treat chronic diseases, such as inflammatory bowel disease (IBD), metabolic symptoms, and obesity. While targeting the gut microbiota is an innovative means for treating IBD, it typically requires an extended treatment time, hampering its potential application. Herein, using an established natural-lipid nanoparticle (nLNP) platform, we demonstrate that nLNPs encapsulated with the drug candidate 6-shogaol (6S/nLNP) distinctly altered microbiota composition within one day of treatment, significantly accelerating a process that usually requires five days using free 6-shogaol (6S)...
August 28, 2021: Pharmaceutics
#28
JOURNAL ARTICLE
Aaron M Kearney, Yufan Yan, Jonathan T Bricker, Jennifer L Pincus, Mohammed S Alghoul
BACKGROUND: Capsular contracture is a well-recognized complication following prosthetic breast reconstruction. It has been the authors' observation that some patients undergoing breast reconstruction experience contracture specifically of the acellular dermal matrix placed at the time of their tissue expander insertion. The goal of the authors' study was to identify clinical and histologic findings associated with the development of acellular dermal matrix-associated contracture. METHODS: The authors performed a retrospective cohort study of all patients undergoing bilateral implant-based breast reconstruction performed by the senior author (M...
November 1, 2021: Plastic and Reconstructive Surgery
#29
JOURNAL ARTICLE
Emile Alghoul, Jihane Basbous, Angelos Constantinou
Inducible biomolecular condensates play fundamental roles in cellular responses to intracellular and environmental cues. Knowledge about their composition is crucial to understand the functions that arise specifically from the assembly of condensates. This protocol combines an optogenetic and an efficient proximity labeling approach to analyze protein modifications driven by protein condensation in cultured cells. Low endogenous biotin level ensures sharp signals. For complete details on the use and execution of this protocol, please refer to Frattini et al...
September 17, 2021: STAR protocols
#30
JOURNAL ARTICLE
Osaid Alser, Heba Alghoul, Zahra Alkhateeb, Ayah Hamdan, Loai Albarqouni, Kiran Saini
BACKGROUND: The COVID-19 pandemic threatens to overwhelm the capacity of a vulnerable healthcare system in the occupied Palestinian territory (oPt). We aimed to evaluate the availability of personal protective equipment (PPE) and the level of preparedness among HCWs in the oPt. METHODS: A cross-sectional study was conducted using a validated online questionnaire distributed through convenient sampling between March 30, 2020 and April 12, 2020. Outcomes were availability of PPE, healthcare workers (HCWs) preparedness in oPt for COVID-19 pandemic, and regional and hospital differences in oPt in terms of availability of PPE and HCWs preparedness...
August 3, 2021: BMC Health Services Research
#31
JOURNAL ARTICLE
Elena Roel, Andrea Pistillo, Martina Recalde, Anthony G Sena, Sergio Fernandez-Bertolin, Maria Aragon, Diana Puente, Waheed-Ul-Rahman Ahmed, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, Clair Blacketer, William Carter, Paula Casajust, Aedín C Culhane, Dalia Dawoud, Frank DeFalco, Scott L DuVall, Thomas Falconer, Asieh Golozar, Mengchun Gong, Laura Hester, George Hripcsak, Eng Hooi Tan, Hokyun Jeon, Jitendra Jonnagaddala, Lana Yh Lai, Kristine E Lynch, Michael E Matheny, Daniel R Morales, Karthik Natarajan, Fredrik Nyberg, Anna Ostropolets, Jose D Posada, Albert Prats-Uribe, Christian G Reich, Donna R Rivera, Lisa M Schilling, Isabelle Soerjomataram, Karishma Shah, Nigam H Shah, Yang Shen, Matthew Spotnitz, Vignesh Subbian, Marc A Suchard, Annalisa Trama, Lin Zhang, Ying Zhang, Patrick B Ryan, Daniel Prieto-Alhambra, Kristin Kostka, Talita Duarte-Salles
BACKGROUND: We described the demographics, cancer subtypes, comorbidities, and outcomes of patients with a history of cancer and COVID-19. Secondly, we compared patients hospitalized with COVID-19 to patients diagnosed with COVID-19 and patients hospitalized with influenza. METHODS: We conducted a cohort study using eight routinely-collected healthcare databases from Spain and the US, standardized to the Observational Medical Outcome Partnership common data model...
July 16, 2021: Cancer Epidemiology, Biomarkers & Prevention
#32
JOURNAL ARTICLE
Martina Recalde, Elena Roel, Andrea Pistillo, Anthony G Sena, Albert Prats-Uribe, Waheed-Ul-Rahman Ahmed, Heba Alghoul, Thamir M Alshammari, Osaid Alser, Carlos Areia, Edward Burn, Paula Casajust, Dalia Dawoud, Scott L DuVall, Thomas Falconer, Sergio Fernández-Bertolín, Asieh Golozar, Mengchun Gong, Lana Yin Hui Lai, Jennifer C E Lane, Kristine E Lynch, Michael E Matheny, Paras P Mehta, Daniel R Morales, Karthik Natarjan, Fredrik Nyberg, Jose D Posada, Christian G Reich, Peter R Rijnbeek, Lisa M Schilling, Karishma Shah, Nigam H Shah, Vignesh Subbian, Lin Zhang, Hong Zhu, Patrick Ryan, Daniel Prieto-Alhambra, Kristin Kostka, Talita Duarte-Salles
BACKGROUND: A detailed characterization of patients with COVID-19 living with obesity has not yet been undertaken. We aimed to describe and compare the demographics, medical conditions, and outcomes of COVID-19 patients living with obesity (PLWO) to those of patients living without obesity. METHODS: We conducted a cohort study based on outpatient/inpatient care and claims data from January to June 2020 from Spain, the UK, and the US. We used six databases standardized to the OMOP common data model...
July 15, 2021: International Journal of Obesity
#33
COMPARATIVE STUDY
Ashraf Fadel Moh'd, Mohammad Abdallah Khasawneh, Hayel Talal Al-Odwan, Yaser Ahmad Alghoul, Zeid Mohammad Makahleh, Salah E Altarabsheh
BACKGROUND: In the early postoperative period after cardiac surgery the heart may be temporarily dysfunctional and prone to arrhythmias due to the phenomenon of myocardial stunning, vasoplegic syndrome, systemic inflammatory response syndrome (SIRS), electrolyte disturbances, operative trauma and myocardial edema. Most cases of cardiac arrest after cardiac surgery are reversible. OBJECTIVE: To analyse the factors that may influence the outcome of cardiac arrest after adult and pediatric cardiac surgery...
April 2021: Medical Archives
#34
JOURNAL ARTICLE
Mohammed Alghoul
No abstract text is available yet for this article.
June 27, 2021: Aesthetic Surgery Journal
#35
JOURNAL ARTICLE
Fatima Alghoul, Schaeffer Laure, Gilbert Eriani, Franck Martin
During embryogenesis, Hox mRNA translation is tightly regulated by a sophisticated molecular mechanism that combines two RNA regulons located in their 5'UTR. First, an internal ribosome entry site (IRES) enables cap-independent translation. The second regulon is a translation inhibitory element or TIE, which ensures concomitant cap-dependent translation inhibition. In this study, we deciphered the molecular mechanisms of mouse Hoxa3 and Hoxa11 TIEs. Both TIEs possess an upstream open reading frame (uORF) that is critical to inhibit cap-dependent translation...
June 2, 2021: ELife
#36
JOURNAL ARTICLE
Talita Duarte-Salles, David Vizcaya, Andrea Pistillo, Paula Casajust, Anthony G Sena, Lana Yin Hui Lai, Albert Prats-Uribe, Waheed-Ul-Rahman Ahmed, Thamir M Alshammari, Heba Alghoul, Osaid Alser, Edward Burn, Seng Chan You, Carlos Areia, Clair Blacketer, Scott DuVall, Thomas Falconer, Sergio Fernandez-Bertolin, Stephen Fortin, Asieh Golozar, Mengchun Gong, Eng Hooi Tan, Vojtech Huser, Pablo Iveli, Daniel R Morales, Fredrik Nyberg, Jose D Posada, Martina Recalde, Elena Roel, Lisa M Schilling, Nigam H Shah, Karishma Shah, Marc A Suchard, Lin Zhang, Ying Zhang, Andrew E Williams, Christian G Reich, George Hripcsak, Peter Rijnbeek, Patrick Ryan, Kristin Kostka, Daniel Prieto-Alhambra
No abstract text is available yet for this article.
May 28, 2021: Pediatrics
#37
JOURNAL ARTICLE
Albert Prats-Uribe, Anthony G Sena, Lana Yin Hui Lai, Waheed-Ul-Rahman Ahmed, Heba Alghoul, Osaid Alser, Thamir M Alshammari, Carlos Areia, William Carter, Paula Casajust, Dalia Dawoud, Asieh Golozar, Jitendra Jonnagaddala, Paras P Mehta, Mengchun Gong, Daniel R Morales, Fredrik Nyberg, Jose D Posada, Martina Recalde, Elena Roel, Karishma Shah, Nigam H Shah, Lisa M Schilling, Vignesh Subbian, David Vizcaya, Lin Zhang, Ying Zhang, Hong Zhu, Li Liu, Jaehyeong Cho, Kristine E Lynch, Michael E Matheny, Seng Chan You, Peter R Rijnbeek, George Hripcsak, Jennifer Ce Lane, Edward Burn, Christian Reich, Marc A Suchard, Talita Duarte-Salles, Kristin Kostka, Patrick B Ryan, Daniel Prieto-Alhambra
OBJECTIVE: To investigate the use of repurposed and adjuvant drugs in patients admitted to hospital with covid-19 across three continents. DESIGN: Multinational network cohort study. SETTING: Hospital electronic health records from the United States, Spain, and China, and nationwide claims data from South Korea. PARTICIPANTS: 303 264 patients admitted to hospital with covid-19 from January 2020 to December 2020. MAIN OUTCOME MEASURES: Prescriptions or dispensations of any drug on or 30 days after the date of hospital admission for covid-19...
May 11, 2021: BMJ: British Medical Journal
#38
JOURNAL ARTICLE
Mohammed S Alghoul
No abstract text is available yet for this article.
September 1, 2020: Plastic and Reconstructive Surgery
#39
JOURNAL ARTICLE
Fatima Alghoul, Gilbert Eriani, Franck Martin
RNA folds into secondary structures that can serve in understanding various RNA functions (Weeks KM. Curr Opin Struct Biol 20(3):295-304, 2010). Chemical probing is a method that enables the characterization of RNA secondary structures using chemical reagents that specifically modify RNA nucleotides that are located in single-stranded areas. In our protocol, we used Dimethyl Sulfate (DMS) and Cyclohexyl-3-(2-Morpholinoethyl) Carbodiimide metho-p-Toluene sulfonate (CMCT) that are both base-specific modifying reagents (Behm-Ansmant I, et al...
2021: Methods in Molecular Biology
#40
JOURNAL ARTICLE
Mohammed S Alghoul, Jonathan T Bricker
Postoperative cicatricial lower lid retraction is a challenging surgical problem that often disfigures the shape of the eye and has functional consequences. Depending on the severity, more than one surgical procedure may be needed to achieve the desired lower lid shape and position given the recurrent nature of scarring. Concepts of scar release, establishing lower lid vertical height, soft tissue replacement, and midcheek support are discussed in this video.
January 2021: Aesthetic surgery journal. Open forum
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