keyword
MENU ▼
Read by QxMD icon Read
search

ca gastric

keyword
https://www.readbyqxmd.com/read/29054094/runx3-inhibits-the-proliferation-and-metastasis-of-gastric-cancer-through-regulating-mir-182-hoxa9
#1
Junyan Yu, Xiangyang Tian, Jianlan Chang, Ping Liu, Rong Zhang
OBJECTIVE: This study intended to explore the molecular mechanism of RUNX3 in inhibiting the process of migration and proliferation of gastric cancer (GC) cells. METHODS: The overexpressed plasmids of RUNX3 and the interfering siRNA of RUNX3 were transfected into GC cells. Then, qRT-PCR and western blot were performed to identify the expression level of RUNX3 and miR-182 in tumors and adjacent tissues respectively. ChIP and luciferase assay were performed to detect the relationship between RUNX3 and miR-182 as well as miR-182 and HOXA9...
October 17, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29053678/assay-for-phosphorylation-and-microtubule-binding-along-with-localization-of-tau-protein-in-colorectal-cancer-cells
#2
Md Nazmul Huda, Erdenedolgor Erdene-Ochir, Cheol-Ho Pan
The microtubule-associated protein tau is a neuronal protein that localizes mostly in axons. Generally tau is essential for normal neuronal functioning because it is involved in microtubule assembly and stabilization. Besides neurons, tau is expressed in human breast, prostate, gastric, colorectal, and pancreatic cancers where it shows nearly similar structure and exerts similar functions as the neuronal tau. The amount of tau and its phosphorylation can change its function as a stabilizer of microtubules, and lead to the development of paired helical filaments in different neurodegenerative disorders, such as Alzheimer's disease...
October 10, 2017: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29053193/body-mass-index-at-adolescence-and-risk-of-noncardia-gastric-cancer-in-a-cohort-of-1-79-million-men-and-women
#3
Zohar Levi, Jeremy D Kark, Gilad Twig, Lior Katz, Adi Leiba, Estela Derazne, Dorit Tzur, Irena Liphshitz, Lital Keinan-Boker, Arnon Afek
BACKGROUND: This study assessed adolescent predictors of noncardia gastric cancer (NCGC) with a focus on the body mass index (BMI) in late adolescence. METHODS: This study analyzed a cohort of 1,087,358 Israeli Jewish males and 707,212 Israeli Jewish females who underwent a compulsory physical examination between the ages of 16 and 19 years from 1967 to 2002. By linkage to the national cancer registry, participants were followed for NCGC through December 31, 2012...
October 20, 2017: Cancer
https://www.readbyqxmd.com/read/29053187/xist-promotes-gastric-cancer-gc-progression-through-tgf-%C3%AE-1-via-targeting-mir-185
#4
Quan Zhang, Baiyu Chen, Ping Liu, Jing Yang
LncRNAs and microRNAs can play significant roles in various cancers, including gastric cancer (GC). In our study, we investigated the role of lncRNA XIST in GC. We observed that XIST was increased in MGC803 and BGC823 cells compared to human normal gastric epithelial GES-1 cells. It was also shown that miR-185 was decreased in GC cell lines. Silencing XIST can inhibit the growth of GC cells and bioinformatics analysis was performed to confirm the correlation between XIST and miR-185. Interestingly, a negative correlation was indicated between XIST and miR-185 in GC cells...
October 20, 2017: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29052852/editorial-risk-stratification-for-endoscopic-surveillance-of-metachronous-gastric-cancer-after-endoscopic-resection
#5
EDITORIAL
K M Fock, T L Ang
No abstract text is available yet for this article.
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29052851/editorial-risk-stratification-for-endoscopic-surveillance-of-metachronous-gastric-cancer-after-endoscopic-resection-authors-reply
#6
EDITORIAL
Y Kwon, S Jeon
No abstract text is available yet for this article.
November 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29052277/src-promotes-egf-induced-epithelial-to-mesenchymal-transition-and-migration-in-gastric-cancer-cells-by-upregulating-zeb1-and-zeb2-through-akt
#7
Lei Zhao, Xin Li, Na Song, Aodi Li, Kezuo Hou, Xiujuan Qu, Xiaofang Che, Yunpeng Liu
Epithelial-to-mesenchymal transition (EMT) plays important roles in the migration, invasion and metastasis of cancer cells. However, the role of Src in epidermal growth factor (EGF)-induced EMT and migration in gastric cancer cells remains to be clarified. In the current study, the effect of Src on EGF-stimulated EMT and migration was explored in gastric cancer cells. EGF induced EMT in gastric cancer cells and increased their migratory ability, which was accompanied by the phosphorylation of Src. PP2, the Src inhibitor, markedly suppressed EGF-mediated EMT and migration in gastric cancer cells...
October 20, 2017: Cell Biology International
https://www.readbyqxmd.com/read/29052260/increased-survival-rates-in-gastric-cancer-with-a-narrowing-gender-gap-and-widening-socioeconomic-status-gap-a-period-analysis-from-1984-to-2013
#8
Fengze Sun, Huanhuan Sun, Xiangqiong Mo, Jianjun Tang, Yifeng Liao, Shuncong Wang, Yonghui Su, Haiqing Ma
BACKGROUND: Gastric cancer (GC) has the fifth highest incidence rate of all cancers and has a poor prognosis. However, no recent large-scale and long-term studies have evaluated the incidence and survival rates of individuals with GC. METHODS: In order to explore the change of GC incidence and survival rates by age, gender, race, socioeconomic status (SES), incidence data and survival status of patients with GC between 1984 and 2013 were abstracted from the Surveillance, Epidemiology and End Results (SEER) database...
October 19, 2017: Journal of Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29052140/prion-protein-family-contributes-to-tumorigenesis-via-multiple-pathways
#9
Xiaowen Yang, Zhijun Cheng, Lihua Zhang, Guiru Wu, Run Shi, Zhenxing Gao, Chaoyang Li
A wealth of evidence suggests that proteins from prion protein (PrP) family contribute to tumorigenesis in many types of cancers, including pancreatic ductal adenocarcinoma (PDAC), breast cancer, glioblastoma, colorectal cancer, gastric cancer, melanoma, etc. It is well documented that PrP is a biomarker for PDAC, breast cancer, and gastric cancer. However, the underlying mechanisms remain unclear. The major reasons for cancer cell-caused patient death are metastasis and multiple drug resistance, both of which connect to physiological functions of PrP expressing in cancer cells...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29052085/comparison-of-young-patients-with-gastric-cancer-in-the-united-states-and-china
#10
Vivian E Strong, Ashley Russo, Sam S Yoon, Murray F Brennan, Daniel G Coit, Chao-Hui Zheng, Ping Li, Chang-Ming Huang
BACKGROUND: This study aimed to compare the clinicopathologic characteristics and stage-specific prognosis of young patients with gastric cancer (GC) after curative resection (R0) in the United States and China. METHODS: Data were collected on young patients (age ≤40 years) undergoing R0 resection at one U.S. (n = 79) and one Chinese (n = 257) institution. Patient, surgical, and pathologic variables and stage-specific survival rates were compared. Factors associated with 5-year disease-specific survival (DSS) were determined via multivariate analysis...
October 19, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/29052072/long-term-outcomes-of-endoscopic-submucosal-dissection-in-comparison-to-surgery-in-undifferentiated-type-intramucosal-gastric-cancer-using-propensity-score-analysis
#11
Jun Chul Park, Yong Kang Lee, Soon Young Kim, Yunho Roh, Kyu Yeon Hahn, Sung Kwan Shin, Sang Kil Lee, Yong Chan Lee, Hyoung-Il Kim, Jae-Ho Cheong, Woo Jin Hyung, Sung Hoon Noh
BACKGROUND: The treatment of intramucosal early gastric cancer with undifferentiated-type histologies (UD-EGCs) using endoscopic submucosal dissection (ESD) is controversial. This study aimed to compare the clinical and oncologic long-term outcomes of ESD and surgery for UD-EGCs. METHODS: A prospectively collected database of patients who underwent ESD or surgery between January 2006 and December 2012 was established. Patients who diagnosed with UD-EGC and satisfied the expanded indications of ESD were included...
October 19, 2017: Surgical Endoscopy
https://www.readbyqxmd.com/read/29052053/validation-of-the-american-joint-committee-on-cancer-ajcc-8th-edition-stage-system-for-gastric-cancer-patients-a-population-based-analysis
#12
Xingkang He, Wenrui Wu, Zhenghua Lin, Yue Ding, Jianmin Si, Lei-Min Sun
BACKGROUND: Our aim was to validate the American Joint Committee on Cancer (AJCC) 8th edition stage system for gastric cancer in the Western world and to compare several modifications between the 7th and 8th edition systems. METHODS: Eligible patients having undergone surgical resection of gastric cancer during 2004-2011 from the Surveillance, Epidemiology, and End Results (SEER) database were included in the current study. Survival differences were assessed by Kaplan-Meier curve and log-rank tests...
October 20, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29052052/long-term-outcomes-of-endoscopic-submucosal-dissection-versus-surgery-in-early-gastric-cancer-meeting-expanded-indication-including-undifferentiated-type-tumors-a-criteria-based-analysis
#13
Sunpyo Lee, Kee Don Choi, Minkyu Han, Hee Kyong Na, Ji Yong Ahn, Kee Wook Jung, Jeong Hoon Lee, Do Hoon Kim, Ho June Song, Gin Hyug Lee, Jeong-Hwan Yook, Byung Sik Kim, Hwoon-Yong Jung
BACKGROUND: Endoscopic submucosal dissection (ESD) for early gastric cancer (EGC) meeting the expanded indication is considered investigational. We aimed to compare long-term outcomes of ESD and surgery for EGC in the expanded indication based on each criterion. METHODS: This study included 1823 consecutive EGC patients meeting expanded indication conditions and treated at a tertiary referral center: 916 and 907 patients underwent surgery or ESD, respectively. The expanded indication included four discrete criteria: (I) intramucosal differentiated tumor, without ulcers, size >2 cm; (II) intramucosal differentiated tumor, with ulcers, size ≤3 cm; (III) intramucosal undifferentiated tumor, without ulcers, size ≤2 cm; and (IV) submucosal invasion <500 μm (sm1), differentiated tumor, size ≤3 cm...
October 19, 2017: Gastric Cancer
https://www.readbyqxmd.com/read/29051402/t-tube-biliary-drainage-during-reconstruction-after-pancreaticoduodenectomy-a-single-center-experience
#14
Pasquale Cianci, Gloria Giaracuni, Nicola Tartaglia, Alberto Fersini, Antonio Ambrosi, Vincenzo Neri
AIM: The purpose of this study is to communicate our experience about the results and effectiveness in the use of the Ttube biliary drainage during pancreaticoduodenectomy. MATERIAL OF STUDY: In accordance whit Whipple we perform the gastric antrum resection during pancreaticoduodenectomy. We have treated 42 patients with pancreaticoduodenectomy, 25 males and 17 females with a mean age of 62 years (range: 53-79 years), and in each of them we have placed a biliary T-tube...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29051398/relationship-between-postoperative-complications-and-survival-after-gastrectomy-for-cancer
#15
Paolo Del Rio, Emiliano Bernuzzi, Elisa Bertocchi, Lorenzo Viani, Federico Cozzani, Chiara Montana
BACKGROUND: Surgical resection remains the main curative treatment for gastric cancer but is still affected by high postoperative morbidity and mortality rates, especially in Western countries. MATERIALS AND METHODS: We've analyzed patients treated for gastric cancer at our Operative Unit of ent, extent of lymphadenectomy and survival. General Surgery and Organ Transplantation of the University Hospital of Parma from January 2006 till December 2010, relating the occurrence of eventual complications to sex, age at diagnosis, definitive histological examination, type and duration of surgical treatment...
2017: Annali Italiani di Chirurgia
https://www.readbyqxmd.com/read/29050982/pharmacological-inhibition-of-dusp6-suppresses-gastric-cancer-growth-and-metastasis-and-overcomes-cisplatin-resistance
#16
Qi-Nian Wu, Yi-Fu Liao, Yun-Xin Lu, Yun Wang, Jia-Huan Lu, Zhao-Lei Zeng, Qi-Tao Huang, Hui Sheng, Jing-Ping Yun, Dan Xie, Huai-Qiang Ju, Rui-Hua Xu
Gastric cancer (GC) is the second cause of cancer-related death. Cisplatin (CDDP) is widely used as the standard GC treatment, but relapse and metastasis are common because of intrinsic or acquired drug resistance. The mitogen-activated protein kinase phosphatases (MAPK)-extracellular signal regulated kinases (ERK) pathway contributes to GC progression and drug resistance, but targeting the MAPK-ERK pathway is challenging in GC therapy. Here, we demonstrated that dual-specificity phosphatases 6 (DUSP6) was overexpressed in GC and predicted poor overall survival and progression-free survival...
October 16, 2017: Cancer Letters
https://www.readbyqxmd.com/read/29050933/foxk1-plays-an-oncogenic-role-in-the-development-of-esophageal-cancer
#17
Di Chen, Kai Wang, Xiaowei Li, Mingzuo Jiang, Lu Ni, Bing Xu, Yi Chu, Weijie Wang, Hua Wang, Huijie Kang, Kaichun Wu, Jie Liang, Gui Ren
Forkhead box k1 (FOXK1) is a member of the FOX class of transcription factors and it is dysregulated in many solid tumors including hepatocellular carcinoma, gastric cancer, colorectal cancer and prostate cancer. However, the expression status of FOXK1 and its clinical significance in esophageal cancer (EC) is still uncertain. Our study aimed at investigating the significance of FOXK1 expression in human EC and its biological function in the development of EC. We found that FOXK1 was overexpressed in EC tissues compared with corresponding non-tumor tissues using immunohistochemistry...
October 16, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29050357/oncomir-17-5p-alarm-signal-in-cancer
#18
REVIEW
Madhusudhan Reddy Bobbili, Robert M Mader, Johannes Grillari, Hanna Dellago
Soon after microRNAs entered the stage as novel regulators of gene expression, they were found to regulate -and to be regulated by- the development, progression and aggressiveness of virtually all human types of cancer. Therefore, miRNAs in general harbor a huge potential as diagnostic and prognostic markers as well as potential therapeutic targets in cancer. The miR-17-92 cluster was found to be overexpressed in many human cancers and to promote unrestrained cell growth, and has therefore been termed onco-miR-1...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050356/negative-lymph-node-count-is-a-significant-prognostic-factor-in-patient-with-stage-iv-gastric-cancer-after-palliative-gastrectomy
#19
Changhua Zhuo, Mingang Ying, Ruirong Lin, Xianyi Wu, Shen Guan, Chunkang Yang
Negative lymph node (NLN) count has been validated as a protective predictor in various cancers after radical resection. However, the prognostic value of NLN count in the setting of stage IV gastric cancer patients who have received palliative resection has not been investigated. Surveillance, Epidemiology, and End Results Program (SEER)-registered gastric cancer patients were used for analysis in this study. Kaplan-Meier survival curves and multivariate Cox proportional hazards model were used to assess the risk factors for patients' survivals...
September 19, 2017: Oncotarget
https://www.readbyqxmd.com/read/29050350/surgical-resection-for-hepatic-metastasis-from-gastric-cancer-a-multi-institution-study
#20
Ailin Song, Xiaofeng Zhang, Feng Yu, Debang Li, Wenyu Shao, Yanming Zhou
BACKGROUND: The beneficial effect of surgical resection for hepatic metastasis from gastric cancer (HMGC) remains elusive. This study was conducted to analyze surgical outcomes of HMGC and determine the prognostic factors associated with survival. RESULTS: The in-hospital mortality rate was zero, and the overall morbidity rate was 56%. The overall 1-, 3-, and 5-year survival rate after surgery was 87.5%, 47.6%, and 21.7%, respectively, with a median survival time of 34...
September 19, 2017: Oncotarget
keyword
keyword
92913
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"