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https://www.readbyqxmd.com/read/29932233/il-1%C3%AE-promotes-the-nuclear-translocaiton-of-s100a4-protein-in-gastric-cancer-cells-mgc803-and-the-cell-s-stem-like-properties-through-pi3k-pathway
#1
Aiwen Yu, Yu Wang, Yue Bian, Lisha Chen, Junfu Guo, Wei Shen, Danqi Chen, Shanshan Liu, Xiuju Sun
It has been shown that nuclear expression of S100A4 is significantly correlated with increased metastasis and reduced survival in patients with gastric cancer and many other cancers. However, the factors which could influence the nuclear contents of S100A4 in cancer cells are not clear. It has also been reported that Interleukin-1β (IL-1β) promotes the nuclear translocation of S100A4 in chondrocytes. Previous studies have shown that IL-1β promotes the stemness of colon cancer cells, and S100A4 is also involved in maintaining cancer-initiating cells in head and neck cancers...
June 22, 2018: Journal of Cellular Biochemistry
https://www.readbyqxmd.com/read/29931597/phase-ii-study-of-s-1-plus-oxaliplatin-130-mg-m-2-in-japanese-patients-with-advanced-gastric-cancer
#2
Yosuke Kito, Nozomu Machida, Sadayuki Kawai, Satoshi Hamauchi, Takahiro Tsushima, Akiko Todaka, Tomoya Yokota, Kentaro Yamazaki, Akira Fukutomi, Yusuke Onozawa, Kunihiro Tsuji, Hisashi Doyama, Yutaka Haraguchi, Koji Nakashima, Kenji Kunieda, Keisei Taku, Keita Mori, Hirofumi Yasui
PURPOSE: Although oxaliplatin 130 mg/m2 every 3 weeks was approved for advanced gastric cancer in Japan, data regarding S-1 plus oxaliplatin 130 mg/m2 (SOX130) are limited in Japanese patients with advanced gastric cancer. We investigated the feasibility and safety of SOX130 in Japanese patients with advanced gastric cancer. METHODS: Patients with unresectable or recurrent gastric adenocarcinoma, no previous chemotherapy, and Eastern Cooperative Oncology Group Performance Status of 0-1 were treated with SOX130...
June 21, 2018: International Journal of Clinical Oncology
https://www.readbyqxmd.com/read/29931452/comparison-of-short-term-and-long-term-efficacy-of-laparoscopic-and-open-gastrectomy-in-high-risk-patients-with-gastric-cancer-a-propensity-score-matching-analysis
#3
Bin-Bin Xu, Jun Lu, Zhi-Fang Zheng, Chang-Ming Huang, Chao-Hui Zheng, Jian-Wei Xie, Jia-Bin Wang, Jian-Xian Lin, Qi-Yue Chen, Long-Long Cao, Mi Lin, Ru-Hong Tu, Ze-Ning Huang, Ping Li, Ju-Li Lin
BACKGROUND: To determine whether laparoscopic surgery can be used in high-risk patients with gastric cancer. METHODS: The clinicopathological data of 3743 patients with primary gastric adenocarcinoma, collected from January 2007 to December 2014, were retrospectively analyzed. Patients who had ≥ 1 of the following conditions were defined as high-risk patients: (1) age ≥ 80 years; (2) BMI ≥ 30 kg/m2 ; (3) ASA (American Society of Anesthesiologists) grade ≥ 3; or (4) clinical T stage 4 (cT4)...
June 21, 2018: Surgical Endoscopy
https://www.readbyqxmd.com/read/29930985/interleukin-17a-promotes-parietal-cell-atrophy-by-inducing-apoptosis
#4
Kevin A Bockerstett, Luciana H Osaki, Christine P Petersen, Catherine W Cai, Chun Fung Wong, Thanh-Long M Nguyen, Eric L Ford, Daniel F Hoft, Jason C Mills, James R Goldenring, Richard J DiPaolo
Background & Aims: Atrophic gastritis caused by chronic inflammation in the gastric mucosa leads to the loss of gastric glandular cells, including acid-secreting parietal cells. Parietal cell atrophy in a setting of chronic inflammation induces spasmolytic polypeptide expressing metaplasia, a critical step in gastric carcinogenesis. However, the mechanisms by which inflammation causes parietal cell atrophy and spasmolytic polypeptide expressing metaplasia are not well defined. We investigated the role of interleukin-17A (IL-17A) in causing parietal cell atrophy...
2018: Cellular and Molecular Gastroenterology and Hepatology
https://www.readbyqxmd.com/read/29930941/favoring-d-2-lymphadenectomy-in-gastric-cancer
#5
Ioannis Karavokyros, Adamantios Michalinos
The role of extended lymphadenectomy in the surgical treatment of gastric cancer has been debated for many years. So far six prospective randomized trials and a number of meta-analyses comparing D1 - to D2 -lymphadenectomy in open surgery have been published with contradicting results. The possible oncologic benefit of radical lymphadenectomy has been blurred by a number of reasons. In most of the trials the strategies under comparison were made similar after protocol violations. Imperfect design of the trials could not exclude the influence of cofounding factors...
2018: Frontiers in Surgery
https://www.readbyqxmd.com/read/29929997/hereditary-lobular-breast-cancer-with-an-emphasis-on-e-cadherin-genetic-defect
#6
Giovanni Corso, Joana Figueiredo, Carlo La Vecchia, Paolo Veronesi, Gabriella Pravettoni, Debora Macis, Rachid Karam, Roberto Lo Gullo, Elena Provenzano, Antonio Toesca, Ketti Mazzocco, Fátima Carneiro, Raquel Seruca, Soraia Melo, Fernando Schmitt, Franco Roviello, Alessandra Margherita De Scalzi, Mattia Intra, Irene Feroce, Elisa De Camilli, Maria Grazia Villardita, Chiara Trentin, Francesca De Lorenzi, Bernardo Bonanni, Viviana Galimberti
Recent studies have reported germline CDH1 mutations in cases of lobular breast cancer (LBC) not associated with the classical hereditary diffuse gastric cancer syndrome. A multidisciplinary workgroup discussed genetic susceptibility, pathophysiology and clinical management of hereditary LBC (HLBC). The team has established the clinical criteria for CDH1 screening and results' interpretation, and created consensus guidelines regarding genetic counselling, breast surveillance and imaging techniques, clinicopathological findings, psychological and decisional support, as well as prophylactic surgery and plastic reconstruction...
June 21, 2018: Journal of Medical Genetics
https://www.readbyqxmd.com/read/29929572/copyright-%C3%A2-2018-cognizant-communication-corporation
#7
Jing Tang, Xu Yong Li, Jing Bo Liang, De Wu, Li Peng, Xiaobing Li
Apatinib is an oral TKI with anti-angiogenesis properties, and it is currently approved for the treatment of advanced gastric cancer in China. This agent has also been tested in other human solid tumors, including non-small cell lung cancer (NSCLC). Since the combination of chemotherapy and an anti-angiogenesis agent has been shown to be feasible strategy in NSCLC, it is conceivable that a similar approach combining apatinib with chemotherapy may yield clinical activity. With this in mind, we investigated the efficiency of apatinib in combination with pemetrexed or docetaxel in advanced NSCLC...
June 21, 2018: Oncology Research
https://www.readbyqxmd.com/read/29929476/droplet-digital-pcr-based-circulating-microrna-detection-serve-as-a-promising-diagnostic-method-for-gastric-cancer
#8
Gaoping Zhao, Tao Jiang, Yanzhuo Liu, Guoli Huai, Chunbin Lan, Guiquan Li, Guiqing Jia, Kang Wang, Maozhu Yang
BACKGROUND: Novel non-invasive biomarkers for gastric cancer (GC) are needed, because the present diagnostic methods for GC are either invasive or insensitive and non-specific in clinic. The presence of stable circulating microRNAs (miRNAs) in plasma suggested a promising role as GC biomarkers. METHODS: Based on the quantitative droplet digital PCR (ddPCR), four miRNAs (miR-21, miR-93, miR-106a and miR-106b) related to the presence of GC were identified in plasma from a training cohort of 147 participants and a validation cohort of 28 participants...
June 22, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29929193/induction-of-pro-inflammatory-response-via-activated-macrophage-mediated-nf-%C3%AE%C2%BAb-and-stat3-pathways-in-gastric-cancer-cells
#9
Yujuan Zhou, Longzheng Xia, Qiang Liu, Heran Wang, Jingguan Lin, Linda Oyang, Xiaoyan Chen, Xia Luo, Shiming Tan, Yutong Tian, Min Su, Ying Wang, Pan Chen, Yang Wu, Hui Wang, Qianjin Liao
BACKGROUND/AIMS: Chronic inflammation plays an important role in the initiation and progression of gastric cancer (GC). However, the role and relationship of activated macrophages with gastric mucous epithelium cells in initiating and maintaining the inflammatory process during gastric carcinogenesis remains unclear. METHODS: The tumour associated macrophages (TAMs) density of gastric cancer was characterized by immunohistochemistry, and the relationship between macrophages and gastric epithelium cells was analysed using an in vitro culture system that imitates the inflammatory microenvironment...
June 19, 2018: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29928972/metabolic-profiling-and-correlation-analysis-for-the-determination-of-killer-compounds-of-proliferating-and-clonogenic-hrt-18-colon-cancer-cells-from-lafoensia-pacari
#10
Cristiane Loiva Reichert, Denise Brentan da Silva, Carlos Alexandre Carollo, Almeriane Maria Weffort-Santos, Cid Aimbiré de Moraes Santos
ETHNOPHARMACOLOGICAL RELEVANCE: Lafoensia pacari A. St.-Hil., belonging to the family Lythraceae and popularly known as 'dedaleira' and 'mangava-brava,' is a native tree of the Brazilian Cerrado, and its barks have been traditionally used as a tonic to treat inflammatory conditions, particularly related to gastric ulcers, wounds or fevers and various types of cancer. AIM OF THE STUDY: We have previously demonstrated the apoptogenic effects of the methanolic extract of L...
June 18, 2018: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29928885/a-natural-compound-aristoyagonine-is-identified-as-a-potent-bromodomain-inhibitor-by-mid-throughput-screening
#11
Young Hun Kim, Minsung Kim, Miyoun Yoo, Ji Eun Kim, Heung Kyoung Lee, Jung-Nyoung Heo, Chong Ock Lee, Minjin Yoo, Kwan-Young Jung, Chang-Soo Yun, Sung Woong Moon, Hye Kyung Chang, Chul-Woong Chung, Suhkneung Pyo, Sang Un Choi, Chi Hoon Park
Bromodomain-containing protein 4 (Brd4) is known to play a key role in tumorigenesis. It binds acetylated histones to regulate the expression of numerous genes. Because of the importance of brd4 in tumorigenesis, much research has been undertaken to develop brd4 inhibitors with therapeutic potential. As a result, various scaffolds for bromodomain inhibitors have been identified. To discover new scaffolds, we performed mid-throughput screening using two different enzyme assays, alpha-screen and ELISA. We found a novel bromodomain inhibitor with a unique scaffold, aristoyagonine...
June 18, 2018: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/29928701/adjuvant-chemoradiation-for-gastric-carcinoma-state-of-the-art-and-perspectives
#12
REVIEW
A Schernberg, E Rivin Del Campo, B Rousseau, O Matzinger, M Loi, P Maingon, F Huguet
An estimated 990,000 new cases of gastric cancer are diagnosed worldwide each year. Surgical excision, the only chance for prolonged survival, is feasible in about 20% of cases. Even after surgery, the median survival is limited to 12 to 20 months due to the frequency of locoregional and/or metastatic recurrences. This led to clinical trials associating surgery with neoadjuvant or adjuvant treatments to improve tumor control and patient survival. The most studied modalities are perioperative chemotherapy and adjuvant chemoradiotherapy...
March 2018: Clinical and Translational Radiation Oncology
https://www.readbyqxmd.com/read/29928606/radiomic-analysis-using-contrast-enhanced-ct-predict-treatment-response-to-pulsed-low-dose-rate-radiotherapy-in-gastric-carcinoma-with-abdominal-cavity-metastasis
#13
Zhen Hou, Yang Yang, Shuangshuang Li, Jing Yan, Wei Ren, Juan Liu, Kangxin Wang, Baorui Liu, Suiren Wan
Background: To determine the feasibility of radiomic analysis for predicting the therapeutic response of gastric carcinoma (GC) with abdominal cavity metastasis (GCACM) to pulsed low dose rate radiotherapy (PLDRT) using contrast-enhanced computed tomography (CECT) images. Methods: Pretreatment CECT images of 43 GCACM patients were analyzed. Patients with complete response (CR) and partial response (PR) were considered responders, while stable disease (SD) and progressive disease (PD) as non-responders...
May 2018: Quantitative Imaging in Medicine and Surgery
https://www.readbyqxmd.com/read/29928446/small-interfering-rna-mediated-knockdown-of-fatty-acid-synthase-attenuates-the-proliferation-and-metastasis-of-human-gastric-cancer-cells-via-the-mtor-gli1-signaling-pathway
#14
Liang Sun, Yizhou Yao, Guofeng Pan, Shenghua Zhan, Weiqiang Shi, Ting Lu, Jinfeng Yuan, Kangjun Tian, Linhua Jiang, Shiduo Song, Xinguo Zhu, Songbing He
Fatty acid synthase (FASN), the main enzyme involved in de novo lipogenesis, is overexpressed in several types of tumor tissues. In addition, it is associated with tumor cell proliferation, metastasis, epithelial-mesenchymal transition (EMT) and a poor prognosis. However, the precise functions and internal mechanisms of FASN with regard to the proliferation, metastasis and EMT in gastric cancer (GC) cells remain elusive. The present study investigated FASN protein expression in 18 randomly selected pairs of GC tumors and matched normal tissues by western blot analysis...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928430/mir-449c-inhibits-migration-and-invasion-of-gastric-cancer-cells-by-targeting-pfkfb3
#15
Xin Chen, Anping Wang, Xinxia Yue
microRNAs (miRNAs) are important regulators in the development and progression of human gastric cancer (GC). However, the expression and biological function of miR-449c in GC remains unknown. In the present study, miR-449c was demonstrated to be downregulated in GC tissues and cell lines compared with normal. Decreased miR-449c levels were associated with poor prognosis in GC patients. Overexpression of miR-449c inhibited migration and invasion in SGC-7901 cells, while inhibition of miR-449c enhanced migration and invasion in MGC-803 cells...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928414/hypoxia-exposure-upregulates-malat-1-and-regulates-the-transcriptional-activity-of-ptb-associated-splicing-factor-in-a549-lung-adenocarcinoma-cells
#16
Ling Hu, Jing Tang, Xiaohuan Huang, Tao Zhang, Xiaoling Feng
Hypoxia has been reported to be a critical microenvironmental factor that induces cancer metastasis and proliferation in gastric, liver and hepatic cancers; however, the underlying mechanisms of this are largely unknown. Long noncoding RNAs (lncRNAs) have emerged as crucial factors of several aspects of tumor malignancy, including tumorigenesis, metastasis and chemoresistance. However, the potential association of lncRNAs with hypoxia-induced cancer malignancy remains to be determined. In the present study, the differential expression of lncRNAs following the induction of hypoxia in A549 lung adenocarcinoma cells was analyzed reverse transcription-quantitative polymerase chain reaction...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928409/accumulation-of-t-helper-22-cells-interleukin-22-and-myeloid-derived-suppressor-cells-promotes-gastric-cancer-progression-in-elderly-patients
#17
Xuehua Chen, Yanfu Wang, Jiali Wang, Jinhui Wen, Xuzhao Jia, Xiaojun Wang, Hua Zhang
Chronic inflammation and immunosuppression lead to aging and tumorigenesis. T-helper 22 (Th22) cells, interleukin 22 (IL-22) and myeloid-derived suppressor cells (MDSCs) serve an important role in inflammatory-immune diseases and cancer. However, the status of Th22 cells, IL-22 and MDSCs in aging and elderly gastric cancer progression is unknown. In the present study, 39 elderly patients with gastric cancer (EGC), 32 elderly healthy controls (HE) and 31 young healthy controls (HY) were enrolled, and the peripheral Th22, Th17 and Th1 cells, and MDSCs, were examined using flow cytometry...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928407/the-composition-and-variation-of-the-bcr-cdr3s-in-gastric-cancer
#18
Song Liu, Ying Zhu, Lie-Wen Lin, Shun-Kai Ding, Xiao-Cong Lin, Ke-Li Zhong, Kai Pan, Yong Dai
Gastric cancer (GC) is the fourth most common type of cancer and the second most common cause of cancer-associated mortality worldwide. B cell-associated autoantibodies against tumor-associated antigens are attractive biomarkers for the development of noninvasive serological tests for the early detection of cancer. This is due to their specificity and stability in the sera. In the present study multiplex polymerase chain reaction and Illumina high-throughput sequencing (HTS) was used to study the composition and variation of the B cell receptor (BCR) complimentary-determining region 3 (CDR3) in GC...
July 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928369/gene-microarray-analysis-of-the-circular-rnas-expression-profile-in-human-gastric-cancer
#19
Yonghua Shen, Juanjuan Zhang, Ziyi Fu, Bin Zhang, Min Chen, Xiufeng Ling, Xiaoping Zou
Human gastric cancer is a common malignant neoplasm of the digestive system and represents a threat to human health worldwide. The mechanisms underlying gastric cancer germination and development are not yet fully understood. Circular RNAs (circRNAs) serve crucial roles in various physiological and pathological processes, particularly cancer. However, few studies have focused on the mechanisms involving circRNAs in gastric cancer. Therefore the present study set out to identify the differentially expressed circRNAs in gastric cancer...
June 2018: Oncology Letters
https://www.readbyqxmd.com/read/29928357/annexin-a7-expression-is-downregulated-in-late-stage-gastric-cancer-and-is-negatively-correlated-with-the-differentiation-grade-and-apoptosis-rate
#20
Weihua Ye, Yong Li, Liqiao Fan, Qun Zhao, Hufang Yuan, Bibo Tan, Zhidong Zhang
Annexin A7 is a member of the Annexin A family, which participates in various biological processes. Accumulating evidence has demonstrated that Annexin A7 serves an important role in tumorigenesis and is dysregulated in multiple types of cancer. However, the role of Annexin A7 in the tumorigenesis of gastric cancer remains to be determined. The present study revealed that Annexin A7 expression is downregulated in late-stage gastric cancer and is negatively correlated with the differentiation grade and apoptosis...
June 2018: Oncology Letters
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