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https://www.readbyqxmd.com/read/28822889/metformin-targets-gastric-cancer-stem-cells
#1
Sarah Courtois, Raúl V Durán, Julie Giraud, Elodie Sifré, Julien Izotte, Francis Mégraud, Philippe Lehours, Christine Varon, Emilie Bessède
Gastric cancer is the third leading cause of cancer-related deaths worldwide and has still a poor prognosis. Therefore, new therapeutic strategies are needed: among them, targeting cancer stem cells (CSCs) could offer new opportunities. The aim of our study was to evaluate the anti-tumoural effect of metformin on gastric cancer in vitro and in vivo and especially, to determine whether this molecule could target the gastric CSCs. Metformin effects were evaluated on the proliferation and tumourigenic properties of the gastric CSCs from patient-derived primary tumour xenografts (PDXs) and cancer cell lines (MKN45, AGS and MKN74) in vitro in conventional 2 dimensional (2D) and in 3 dimensional (3D) culture systems, in which only CSCs are able to form tumourspheres and in mouse xenograft models in vivo...
August 17, 2017: European Journal of Cancer
https://www.readbyqxmd.com/read/28822338/in-vitro-bioaccessibility-and-health-risk-assessment-of-heavy-metals-in-atmospheric-particulate-matters-from-three-different-functional-areas-of-shanghai-china
#2
Huang Huang, Ying Jiang, Xiaoyun Xu, Xinde Cao
The bioaccessibility and human health risks of heavy metals in PM2.5 and PM10 samples from three functional areas of Shanghai, China including a commercial area (CA), a residential area (RA), and an industrial area (IA), were investigated. Gamble's solution and physiologically based extraction test were employed to simulate human respiratory and digestive system, respectively. Both PM2.5 and PM10 concentration in the three areas exceeded the guideline of WHO, and followed the order of IA>CA≈RA. Zinc and Pb were the most abundant metals with a concentration range of 0...
August 16, 2017: Science of the Total Environment
https://www.readbyqxmd.com/read/28821938/depth-of-response-predicts-the-clinical-outcome-of-advanced-her2-positive-gastric-cancer-to-trastuzumab-based-first-line-chemotherapy
#3
Shigenori Kadowaki, Toshiki Masuishi, Tetsuya Eto, Yukiya Narita, Hiroya Taniguchi, Takashi Ura, Masashi Ando, Masahiro Tajika, Yasumasa Niwa, Yasushi Yatabe, Kei Muro
PURPOSE: Accumulating evidence suggests that response-related parameters such as depth of response (DpR) might be associated with survival in colorectal cancer, which has not been shown in gastric cancer. This study aimed to evaluate whether DpR was associated with clinical outcomes in HER2-positive AGC patients treated with trastuzumab-based chemotherapy. METHODS: Fifty-seven HER2-positive AGC patients who were treated with trastuzumab in combination with fluoropyrimidines plus cisplatin therapy as first-line treatment were retrospectively enrolled...
August 18, 2017: Cancer Chemotherapy and Pharmacology
https://www.readbyqxmd.com/read/28819789/left-gastric-artery-lymph-nodes-should-be-included-in-d1-lymph-node-dissection-in-gastric-cancer
#4
Naruhiko Ikoma, Mariela Blum, Jeannelyn S Estrella, Xuemei Wang, Keith F Fournier, Paul F Mansfield, Jaffer A Ajani, Brian D Badgwell
BACKGROUND: The Japanese Classification of Gastric Carcinoma includes the left gastric artery (#7) lymph nodes (LNs) in the recommended extent of D1 LN dissection, but this recommendation has not been validated in western institutions. METHODS: We reviewed data from a prospectively maintained database of gastric cancer patients who underwent resection at our academic cancer center and had a separate pathologic assessment of #7 LN in 2005-2016. Risk factors for #7 LN metastases and overall survival were examined by uni- and multivariable analyses...
August 17, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28819779/curcuma-wenyujin-y-h-chen-et-c-ling-n-butyl-alcohol-extract-inhibits-ags-cell-helicobacter-pylori-caga-vaca-promoted-invasiveness-by-down-regulating-caudal-type-homeobox-transcription-factor-and-claudin-2-expression
#5
Hai-Feng Jin, Jin-Feng Dai, Li-Na Meng, Bin Lu
OBJECTIVE: To investigate the effects and possible mechanisms of action of Curcuma wenyujin Y. H. Chen et C. Ling n-Butyl alcohol extract (CWNAE) on repression of human gastric cancer (GC) AGS cell invasion induced by co-culturing with Helicobacter pylori (HP). METHODS: AGS cells were cultured with HP of positive or negative cytotoxin-associated gene A (CagA) and vacuolating cytotoxin gene A (VacA) expression (CagA+/- or VacA+/-) and divided into 5 group. Group A was cultured without HP as a control, Group B with HPCagA+VacA+, Group C with HPCagA-VacA-, Group D with HPCagA+VacA+ and CWNAE, and Group E with HPCagA-VacA- and CWNAE...
August 17, 2017: Chinese Journal of Integrative Medicine
https://www.readbyqxmd.com/read/28819425/selective-gastric-cancer-patients-with-peritoneal-seeding-benefit-from-gastrectomy-after-palliative-chemotherapy-a-propensity-score-matching-analysis
#6
Shu-Qiang Yuan, Run-Cong Nie, Shi Chen, Xiao-Jiang Chen, Yong-Ming Chen, Li-Pu Xu, Li-Fang Yang, Zhi-Wei Zhou, Jun-Sheng Peng, Ying-Bo Chen
Background: The present study aimed to explore whether gastric cancer patients with peritoneal seeding after receiving palliative chemotherapy could benefit from gastrectomy and to identify patients with peritoneal seeding who should be selected to receive gastrectomy. Methods: A total of 201 gastric cancer patients were diagnosed with peritoneal seeding and received palliative chemotherapy. Propensity score matching (PSM) was performed to balance the selection bias. Results: After PSM, compared with non-gastrectomy group, gastrectomy group had a longer median overall survival (OS) (23...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819421/simultaneous-quantification-of-serum-multi-phospholipids-as-potential-biomarkers-for-differentiating-different-pathophysiological-states-of-lung-stomach-intestine-and-pancreas
#7
Yumei Guo, Junling Ren, Xiaoou Li, Xiaofeng Liu, Ning Liu, Yanmin Wang, Zhili Li
Background: Aberrant lipid metabolism is closely associated with cancer. Materials & Methods: Serum levels of sphingomyelins (SM) (34:1), phosphatidylcholine (PC) (34:2), PC(34:1), PC(36:4), PC(36:3), and PC(36:2) in 1449 serum samples (including 599 normal controls, 69 patients with benign lung diseases (BLDs), 61 with benign colorectal diseases, 54 with benign gastric diseases, 67 with benign pancreatic diseases, and 246 with lung cancer (LC), 144 with colorectal cancer, 94 with gastric cancer, 115 with pancreatic cancer) were quantified simultaneously based on their respective calibration equations with correlation coefficient of >0...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819419/osteopontin-a-promising-biomarker-for-cancer-therapy
#8
REVIEW
Ran Wei, Janet Pik Ching Wong, Hang Fai Kwok
Osteopontin (OPN), a multifunctional protein, has emerged as a potentially valuable biomarker for diagnosing and treating cancers. Recent research focuses on its involvement in tumor biology including the cell proliferation, survival, angiogenesis, invasion, and metastasis. Understanding the molecular mechanisms and pharmacological effects of OPN in cancer development could lead to new targets for improving cancer diagnosis and treatment. This review explains how the structurally conserved domains of OPN are associated with OPN signaling mediators and CD44, and how the conserved OPN domains determine biological functions...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819392/long-term-trends-in-primary-sites-of-gastric-adenocarcinoma-in-japan-and-the-united-states
#9
Michitaka Honda, Sandra L Wong, Mark A Healy, Toshifusa Nakajima, Masayuki Watanabe, Shingo Fukuma, Shunichi Fukuhara, John Z Ayanian
Background: The incidence and characteristics of gastric cancer have been shown to vary widely across Western and Eastern countries. Our study had two aims: to evaluate long-term trends in gastric adenocarcinoma in Japan over a period of 70 years, and to anticipate the future of gastric cancer in Japan, through comparison with data from the United States. Methods: Japanese patient data for 19,306 incident cases of gastric adenocarcinoma from 1946 - 2014 were collected from the Gastric Cancer Database at the Cancer Institute Hospital, Tokyo, Japan (CIH-GCDB)...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819389/discovery-of-non-invasive-glycan-biomarkers-for-detection-and-surveillance-of-gastric-cancer
#10
Ruihuan Qin, Junjie Zhao, Wenjun Qin, Zejian Zhang, Ran Zhao, Jing Han, Yupeng Yang, Lixiao Li, Xuefei Wang, Shifang Ren, Yihong Sun, Jianxin Gu
Purpose: Gastric cancer (GC), one of the world's top five most common cancers, is the third leading cause of cancer related death. It is urgent to identify non-invasive biomarkers for GC. The objective of our study was to find out non-invasive biomarkers for early detection and surveillance of GC based on glycomic analysis. Method: Ethyl esterification derivatization combined with MALDI-TOF MS analysis was employed for the comprehensive serum glycomic analysis in order to investigate glycan markers that would indicate the onset and progression of gastric cancer...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819388/role-of-y-box-protein-1-in-cancer-as-potential-biomarker-and-novel-therapeutic-target
#11
REVIEW
Pramod Kumar Maurya, Alok Mishra, Birendra Singh Yadav, Swati Singh, Prashant Kumar, Amit Chaudhary, Shweta Srivastava, Suriya Narayan Murugesan, Ashutosh Mani
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and translation factor during expression of several proteins. It is a vital oncoprotein that regulates cancer cell progression and proliferation. YB-1 is over-expressed in various human cancers such as breast cancer, colon cancer, lung cancer, gastric cancer, oesophageal cancer and glioblastoma. Nuclear expression of YB-1 is found to be associated with multidrug resistance and cancer cell progression. YB-1 is reported to regulate many cellular signalling pathways in different types of cancer proliferation...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819380/phase-ii-trial-of-adjuvant-immunotherapy-with-autologous-tumor-derived-gp96-vaccination-in-patients-with-gastric-cancer
#12
Kecheng Zhang, Zheng Peng, Xiaohui Huang, Zhi Qiao, Xinxin Wang, Ning Wang, Hongqing Xi, Jianxin Cui, Yunhe Gao, Xijian Huang, Hua Gao, Bo Wei, Lin Chen
Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October 2012 to December 2015. Thirty-eight patients received gp96 vaccination plus chemotherapy and 35 received chemotherapy alone. The primary endpoints were disease-free survival (DFS) and toxicity...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819379/hypoxia-inducible-factor-1-alpha-correlates-with-tumor-associated-macrophages-infiltration-influences-survival-of-gastric-cancer-patients
#13
Wei-Jie Zhang, Cheng Chen, Zhi-Hua Zhou, Shan-Ting Gao, Teong Jin Tee, Liu-Qing Yang, Yuan-Yuan Xu, Tao-Hong Pang, Xin-Yun Xu, Qi Sun, Min Feng, Hao Wang, Chun-Lei Lu, Guo-Zhong Wu, Sheng Wu, Wen-Xian Guan, Gui-Fang Xu
Background: Hypoxia was a common feature for accelerating tumor metastasis by both inducting epithelial-mesenchymal transition (EMT) of tumor cells and polarization of tumor-associated macrophages (TAMs). The association and roles between hypoxia, EMT and TAMs in the biological behavior of gastric cancer (GC) for the time being recurrence is unclear. Material and methods: hypoixa by expression of hypoxia-inducible factor-1 alpha (HIF-1α), polarized functional status of infiltrated TAMs by immunohistochemical staining of CD68 and CD163, and the expression of E-cadherin as EMT property had been evaluated in 236 patients consecutive with histologically confirmed GC...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819369/in-vitro-cytotoxic-activities-of-the-oral-platinum-iv-prodrug-oxoplatin-and-hsp90-inhibitor-ganetespib-against-a-panel-of-gastric-cancer-cell-lines
#14
Lukas Klameth, Barbara Rath, Gerhard Hamilton
Gastric cancer exhibits a poor prognosis and is the third most common cause of cancer death worldwide. Chemotherapy of metastatic gastric cancer is based on combinations of platinum drugs and fluoropyrimidines, with added agents. Oxoplatin is a stable oral platinum(IV) prodrug which is converted to a highly active tetrachlorido(IV) complex under acidic conditions. In the present work, we studied the cytotoxic effects of oxoplatin against a panel of four gastric cancer cell lines in vitro. Furthermore, the role of HSP90 in chemoresistance of these lines was investigated using the specific inhibitor ganetespib...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28819095/non-coding-rnas-participate-in-the-regulatory-network-of-cldn4-via-cerna-mediated-mirna-evasion
#15
Yong-Xi Song, Jing-Xu Sun, Jun-Hua Zhao, Yu-Chong Yang, Jin-Xin Shi, Zhong-Hua Wu, Xiao-Wan Chen, Peng Gao, Zhi-Feng Miao, Zhen-Ning Wang
Thousands of genes have been well demonstrated to play important roles in cancer progression. As genes do not function in isolation, they can be grouped into "networks" based on their interactions. In this study, we discover a network regulating Claudin-4 in gastric cancer. We observe that Claudin-4 is up-regulated in gastric cancer and is associated with poor prognosis. Claudin-4 reinforce proliferation, invasion, and EMT in AGS, HGC-27, and SGC-7901 cells, which could be reversed by miR-596 and miR-3620-3p...
August 18, 2017: Nature Communications
https://www.readbyqxmd.com/read/28819089/follow-up-practices-of-surgeons-and-medical-oncologists-in-australia-and-new-zealand-following-resection-of-esophagogastric-cancers
#16
Tim Chew, Tim Bright, Timothy J Price, David I Watson, Peter G Devitt
PURPOSE: Follow-up practices for patients who have undergone surgical resection of esophagogastric malignancies are variable and poorly documented. To better understand practice, a questionnaire was used to survey surgeons and medical oncologists to determine whether any consensus exists. METHODS: An opt-in online questionnaire was sent to esophagogastric surgeons and medical oncologists via the membership lists for the Australian and New Zealand Gastric and Oesophageal Surgery Association (ANZGOSA), the Australian Gastro-Intestinal Trials Groups (AGITG), and the Medical Oncology Group of Australia (MOGA)...
August 15, 2017: Annals of Thoracic and Cardiovascular Surgery
https://www.readbyqxmd.com/read/28818671/incidence-and-risk-of-cardiotoxicity-in-cancer-patients-treated-with-targeted-therapies
#17
REVIEW
Matteo Santoni, Federico Guerra, Alessandro Conti, Alessandra Lucarelli, Silvia Rinaldi, Laura Belvederesi, Alessandro Capucci, Rossana Berardi
BACKGROUND: Cardiotoxicityis a serious side effect of molecularly targeted agents. The purpose of this study was to evaluate the incidence and Relative Risk (RR) of developing all-grade and high-grade cardiotoxicity in patients with solid tumors receiving targeted agents through a revised meta-analysis of available clinical trials. METHODS: The scientific literature regarding cardiotoxicity was extensively analyzed using MEDLINE, PubMed, Embase and Cochrane Central Register of Controlled Trials (CENTRAL)...
July 28, 2017: Cancer Treatment Reviews
https://www.readbyqxmd.com/read/28818202/risk-of-arterial-thromboembolism-in-patients%C3%A2-with%C3%A2-cancer
#18
Babak B Navi, Anne S Reiner, Hooman Kamel, Costantino Iadecola, Peter M Okin, Mitchell S V Elkind, Katherine S Panageas, Lisa M DeAngelis
BACKGROUND: The risk of arterial thromboembolism in patients with cancer is incompletely understood. OBJECTIVES: The authors aimed to better define this epidemiological relationship, including the effects of cancer stage. METHODS: Using the Surveillance Epidemiology and End Results-Medicare linked database, the authors identified patients with a new primary diagnosis of breast, lung, prostate, colorectal, bladder, pancreatic, or gastric cancer or non-Hodgkin lymphoma from 2002 to 2011...
August 22, 2017: Journal of the American College of Cardiology
https://www.readbyqxmd.com/read/28818111/estimates-of-cancer-incidence-and-mortality-in-china-2013
#19
Rongshou Zheng, Hongmei Zeng, Siwei Zhang, Wanqing Chen
INTRODUCTION: Population-based cancer registration data are collected by the National Central Cancer Registry in China every year. Cancer incident cases and cancer deaths in 2013 were analyzed. METHODS: Through the procedure of quality control, reported data from 255 registries were accepted to establish the national database for cancer estimates. Incidences and mortalities were calculated with stratification by area (urban/rural), sex (male/female), age group (0, 1-4, 5-9, 10-14 … 80-84, and 85-year-old and above), and cancer site...
August 17, 2017: Chinese Journal of Cancer
https://www.readbyqxmd.com/read/28818100/mir-140-5p-suppresses-the-proliferation-migration-and-invasion-of-gastric-cancer-by-regulating-yes1
#20
Zheng Fang, Shuai Yin, Ruochuan Sun, Shangxin Zhang, Min Fu, Youliang Wu, Tao Zhang, Junaid Khaliq, Yongxiang Li
BACKGROUND: The aberrant expression of microRNA-140-5p (miR-140-5p) has been described in gastric cancer (GC). However, the role of miR-140-5p in GC remains unclear. In this study, the prognostic relevance of miR-140-5p in GC was investigated and YES1 was identified as a novel target of miR-140-5p in regulating tumor progression. METHODS: miR-140-5p level was determined in 20 paired frozen specimens through quantitative real-time PCR, and analyzed in tissue microarrays through in situ hybridization...
August 17, 2017: Molecular Cancer
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