keyword
https://read.qxmd.com/read/37204841/the-prognostic-nutritional-index-in-hpv-negative-head-and-neck-squamous-cell-carcinoma-treated-with-upfront-surgery-a-multi-institutional-series
#21
JOURNAL ARTICLE
Michele Tomasoni, Cesare Piazza, Alberto Deganello, Paolo Bossi, Giancarlo Tirelli, Piero Nicolai, Maria Cristina Da Mosto, Gabriele Molteni, Vittorio Giacomarra, Pietro Canzi, Stefano Pelucchi, Jerry Polesel, Daniele Borsetto, Paolo Boscolo-Rizzo
OBJECTIVES: To evaluate the prognostic value of pre-treatment prognostic-nutritional index (PNI) in patients with HPV-negative head and neck squamous cell carcinoma (HNSCC). METHODS: A multi-institutional retrospective series of HPV-negative, Stages II-IVB, HNSCCs treated with upfront surgery was evaluated. Correlation of pre-operative blood markers and PNI with 5-year overall (OS) and relapse-free (RFS) survival was tested using linear and restricted cubic spline models, as appropriate...
June 2023: Acta Otorhinolaryngologica Italica
https://read.qxmd.com/read/37182790/microbiome-and-immuno-metabolic-dysregulation-in-patients-with-major-depressive-disorder-with-atypical-clinical-presentation
#22
REVIEW
Alexander Refisch, Zümrüt Duygu Sen, Tilman E Klassert, Anne Busch, Bianca Besteher, Lena Vera Danyeli, Dario Helbing, Ulrike Schulze-Späte, Andreas Stallmach, Michael Bauer, Gianni Panagiotou, Ilse D Jacobsen, Hortense Slevogt, Nils Opel, Martin Walter
Depression is highly prevalent (6% 1-year prevalence) and is the second leading cause of disability worldwide. Available treatment options for depression are far from optimal, with response rates only around 50%. This is most likely related to a heterogeneous clinical presentation of major depression disorder (MDD), suggesting different manifestations of underlying pathophysiological mechanisms. Poorer treatment outcomes to first-line antidepressants were reported in MDD patients endorsing an "atypical" symptom profile that is characterized by preserved reactivity in mood, increased appetite, hypersomnia, a heavy sensation in the limbs, and interpersonal rejection sensitivity...
September 1, 2023: Neuropharmacology
https://read.qxmd.com/read/37115481/neutrophil-dys-function-due-to-altered-immuno-metabolic-axis-in-type-2-diabetes-implications-in-combating-infections
#23
REVIEW
Pooja Yedehalli Thimmappa, Sampara Vasishta, Kailash Ganesh, Aswathy S Nair, Manjunath B Joshi
Metabolic and inflammatory pathways are highly interdependent, and both systems are dysregulated in Type 2 diabetes (T2D). T2D is associated with pre-activated inflammatory signaling networks, aberrant cytokine production and increased acute phase reactants which leads to a pro-inflammatory 'feed forward loop'. Nutrient 'excess' conditions in T2D with hyperglycemia, elevated lipids and branched-chain amino acids significantly alter the functions of immune cells including neutrophils. Neutrophils are metabolically active cells and utilizes energy from glycolysis, stored glycogen and β-oxidation while depending on the pentose phosphate pathway for NADPH for performing effector functions such as chemotaxis, phagocytosis and forming extracellular traps...
April 28, 2023: Human Cell
https://read.qxmd.com/read/37108739/circadian-disruption-and-mental-health-the-chronotherapeutic-potential-of-microbiome-based-and-dietary-strategies
#24
REVIEW
Pilar Codoñer-Franch, Marie Gombert, José Martínez-Raga, María Carmen Cenit
Mental illness is alarmingly on the rise, and circadian disruptions linked to a modern lifestyle may largely explain this trend. Impaired circadian rhythms are associated with mental disorders. The evening chronotype, which is linked to circadian misalignment, is a risk factor for severe psychiatric symptoms and psychiatric metabolic comorbidities. Resynchronization of circadian rhythms commonly improves psychiatric symptoms. Furthermore, evidence indicates that preventing circadian misalignment may help reduce the risk of psychiatric disorders and the impact of neuro-immuno-metabolic disturbances in psychiatry...
April 20, 2023: International Journal of Molecular Sciences
https://read.qxmd.com/read/36949598/atrial-arrhythmias-and-heart-failure-%C3%A2-a-modern-view-of-an-old-paradox
#25
JOURNAL ARTICLE
Beniamino Rosario Pagliaro, Gianluca Mincione, Antonio Taormina, Carlo Ceriotti, Luca Poggio, Francesco Cannata, Guido Del Monaco, Mauro Gitto, Vincenzo Battaglia, Gabriele Pinna, Paola Galimberti, Ferdinando Loiacono, Marta Pellegrino, Cristina Panico, Renato Bragato, Giulio Stefanini, Gianluigi Condorelli, Daniela Pini, Antonio Frontera
BACKGROUND: Heart failure (HF) and atrial arrhythmias (AAs) are two clinical conditions that characterize the daily clinical practice of cardiologists. In this perspective review, we analyze the shared etiopathogenetic pathways of atrial arrhythmias, which are the most common cause of atrial arrhythmias-induced cardiomyopathy (AACM) and HF. HYPOTHESIS: The aim is to explore the pathophysiology of these two conditions considering them as a "unicum", allowing the definition of a cardiovascular continuum where it is possible to predict the factors and to identify the patient phenotype most at risk to develop HF due to atrial arrhythmias...
March 22, 2023: Pacing and Clinical Electrophysiology: PACE
https://read.qxmd.com/read/36858655/role-of-mitochondria-in-regulating-immune-response-during-bacterial-infection
#26
JOURNAL ARTICLE
Shaziya Khan, Swarnali Basu, Desh Raj, Amit Lahiri
Mitochondria are dynamic organelles of eukaryotes involved in energy production and fatty acid oxidation. Besides maintaining ATP production, calcium signaling, cellular apoptosis, and fatty acid synthesis, mitochondria are also known as the central hub of the immune system as it regulates the innate immune pathway during infection. Mitochondria mediated immune functions mainly involve regulation of reactive oxygen species production, inflammasome activation, cytokine secretion, and apoptosis of infected cells...
2023: International Review of Cell and Molecular Biology
https://read.qxmd.com/read/36814444/cardiomyocyte-infection-by-trypanosoma-cruzi-promotes-innate-immune-response-and-glycolysis-activation
#27
JOURNAL ARTICLE
Gabriela Venturini, Juliana M Alvim, Kallyandra Padilha, Christopher N Toepfer, Joshua M Gorham, Lauren K Wasson, Diogo Biagi, Sergio Schenkman, Valdemir M Carvalho, Jessica S Salgueiro, Karina H M Cardozo, Jose E Krieger, Alexandre C Pereira, Jonathan G Seidman, Christine E Seidman
INTRODUCTION: Chagas cardiomyopathy, a disease caused by Trypanosoma cruzi ( T. cruzi ) infection, is a major contributor to heart failure in Latin America. There are significant gaps in our understanding of the mechanism for infection of human cardiomyocytes, the pathways activated during the acute phase of the disease, and the molecular changes that lead to the progression of cardiomyopathy. METHODS: To investigate the effects of T. cruzi on human cardiomyocytes during infection, we infected induced pluripotent stem cell-derived cardiomyocytes (iPSC-CM) with the parasite and analyzed cellular, molecular, and metabolic responses at 3 hours, 24 hours, and 48 hours post infection (hpi) using transcriptomics (RNAseq), proteomics (LC-MS), and metabolomics (GC-MS and Seahorse) analyses...
2023: Frontiers in Cellular and Infection Microbiology
https://read.qxmd.com/read/36715509/wy14643-increases-herpesvirus-replication-and-inhibits-ifn%C3%AE-production-independently-of-ppar%C3%AE-expression
#28
JOURNAL ARTICLE
Lili Tao, Phillip Dryden, Alexandria Lowe, Guoxun Wang, Amritha Achuthkumar, Tyron Chang, Tiffany A Reese
Peroxisome proliferator activated receptor (PPAR) agonists are commonly used to treat metabolic disorders in humans because they regulate fatty acid oxidation and cholesterol metabolism. In addition to their roles in controlling metabolism, PPAR agonists also regulate inflammation and are immunosuppressive in models of autoimmunity. We aimed to test whether activation of PPARα with clinically relevant ligands could impact gammaherpesvirus infection using murine gammaherpesvirus-68 (MHV68, MuHV-4). We found that PPAR agonists WY14643 and fenofibrate increased herpesvirus replication in vitro ...
January 30, 2023: Microbiology Spectrum
https://read.qxmd.com/read/36690247/immuno-metabolic-effect-of-pancreastatin-inhibitor-psti8-in-diet-induced-obese-mice-in-vitro-and-in-vivo-findings
#29
JOURNAL ARTICLE
Umesh K Goand, Saurabh Verma, Inklisan Patel, Saima Tasneem, Richa Garg, Jiaur R Gayen
AIMS: Pancreastatin (PST), an anti-insulin peptide derived from chromogranin A. Its levels increase in cases of obesity, which contributes to adipose tissue inflammation and insulin resistance. This study aims to investigate the immunometabolic effect of PST inhibitor (PSTi8) against PST by using in vitro and in vivo finding. MAIN METHODS: 3T3-L1 cells were differentiated with or without PSTi8, and Oil Red O staining was performed. J774A.1 cells were used for macrophage polarization study...
January 20, 2023: Life Sciences
https://read.qxmd.com/read/36681548/immuno-metabolic-control-of-the-balance-between-th17-polarized-and-regulatory-t-cells-during-hiv-infection
#30
REVIEW
Alexis Yero, Ralph-Sydney Mboumba Bouassa, Petronela Ancuta, Jerome Estaquier, Mohammad-Ali Jenabian
Th17-polarized CD4+ effector T-cells together with their immunosuppressive regulatory T-cell (Treg) counterparts, with transcriptional profiles governed by the lineage transcription factors RORγt/RORC2 and FOXP3, respectively, are important gatekeepers at mucosal interfaces. Alterations in the Th17/Treg ratios, due to the rapid depletion of Th17 cells and increased Treg frequencies, are a hallmark of both HIV and SIV infections and a marker of disease progression. The shift in Th17/Treg balance, in favor of increased Treg frequencies, contributes to gut mucosal permeability, immune dysfunction, and microbial translocation, subsequently leading to chronic immune activation/inflammation and disease progression...
January 18, 2023: Cytokine & Growth Factor Reviews
https://read.qxmd.com/read/36655056/efficacy-of-celecoxib-add-on-treatment-for-immuno-metabolic-depression-protocol-of-the-inflamed-double-blind-placebo-controlled-randomized-controlled-trial
#31
JOURNAL ARTICLE
J C Zwiep, P M Bet, D Rhebergen, M T Nurmohamed, C H Vinkers, B W J H Penninx, Y Milaneschi, F Lamers
INTRODUCTION: As the role of (neuro)inflammation in depression pathophysiology is emerging, augmentation of antidepressant treatments with anti-inflammatory drugs have shown beneficial results, but not consistently across all studies. Inconsistencies may be due to depression biological and clinical heterogeneity. Immuno-Metabolic Depression (IMD) has been put forward as a form of depression characterized by the clustering of low-grade inflammation, metabolic dysregulations and atypical, energy-related symptoms (overeating, weight gain, hypersomnia, fatigue and leaden paralysis)...
February 2023: Brain, behavior, & immunity health
https://read.qxmd.com/read/36626225/microrna-33-deficiency-in-macrophages-enhances-autophagy-improves-mitochondrial-homeostasis-and-protects-against-lung-fibrosis
#32
JOURNAL ARTICLE
Farida Ahangari, Nathan L Price, Shipra Malik, Maurizio Chioccioli, Thomas Bärnthaler, Taylor S Adams, Jooyoung Kim, Sai Pallavi Pradeep, Shuizi Ding, Carlos Cosme, Kadi-Ann S Rose, John E McDonough, Nachelle R Aurelien, Gabriel Ibarra, Norihito Omote, Jonas C Schupp, Giuseppe DeIuliis, Julian A Villalba Nunez, Lokesh Sharma, Changwan Ryu, Charles S Dela Cruz, Xinran Liu, Antje Prasse, Ivan Rosas, Raman Bahal, Carlos Fernandez-Hernando, Naftali Kaminski
Idiopathic pulmonary fibrosis (IPF) is a progressive and ultimately fatal disease. Recent findings have shown a marked metabolic reprogramming associated with changes in mitochondrial homeostasis and autophagy during pulmonary fibrosis. The microRNA-33 (miR-33) family of microRNAs (miRNAs) encoded within the introns of SREBP (sterol regulatory element binding protein) genes are master regulators of sterol and fatty acid (FA) metabolism. miR-33 controls macrophage immuno-metabolic response and enhances mitochondrial biogenesis, FA oxidation, and cholesterol efflux...
January 10, 2023: JCI Insight
https://read.qxmd.com/read/36613488/polyphenols-as-drivers-of-a-homeostatic-gut-microecology-and-immuno-metabolic-traits-of-akkermansia-muciniphila-from-mouse-to-man
#33
REVIEW
María Carolina Rodríguez-Daza, Willem M de Vos
Akkermansia muciniphila is a mucosal symbiont considered a gut microbial marker in healthy individuals, as its relative abundance is significantly reduced in subjects with gut inflammation and metabolic disturbances. Dietary polyphenols can distinctly stimulate the relative abundance of A. muciniphila , contributing to the attenuation of several diseases, including obesity, type 2 diabetes, inflammatory bowel diseases, and liver damage. However, mechanistic insight into how polyphenols stimulate A. muciniphila or its activity is limited...
December 20, 2022: International Journal of Molecular Sciences
https://read.qxmd.com/read/36509805/paraoxonase-2-contributes-to-promoting-lipid-metabolism-and-mitochondrial-function-via-autophagy-activation
#34
JOURNAL ARTICLE
Gu-Choul Shin, Hyeong Min Lee, Nayeon Kim, Sang-Ku Yoo, Hyung Soon Park, Leo Sungwong Choi, Kwang Pyo Kim, Ah-Ra Lee, Sang-Uk Seo, Kyun-Hwan Kim
Non-alcoholic fatty liver disease (NAFLD) is an increasingly prevalent immuno-metabolic disease that can progress to hepatic cirrhosis and cancer. NAFLD pathogenesis is extremely complex and is characterized by oxidative stress, impaired mitochondrial function and lipid metabolism, and cellular inflammation. Thus, in-depth research on its underlying mechanisms and subsequent investigation into a potential drug target that has overarching effects on these features will help in the discovery of effective treatments for NAFLD...
December 12, 2022: Scientific Reports
https://read.qxmd.com/read/36508576/glut-1-pkm2-loop-dysregulation-in-patients-with-non-st-segment-elevation-myocardial-infarction-promotes-metainflammation
#35
JOURNAL ARTICLE
Francesco Canonico, Daniela Pedicino, Anna Severino, Ramona Vinci, Davide Flego, Eugenia Pisano, Alessia d'Aiello, Pellegrino Ciampi, Myriana Ponzo, Alice Bonanni, Astrid De Ciutiis, Sara Russo, Marianna Di Sario, Giulia Angelini, Piotr Szczepaniak, Alfonso Baldi, Boguslaw Kapelak, Karol Wierzbicki, Rocco A Montone, Domenico D'Amario, Massimo Massetti, Tomasz J Guzik, Filippo Crea, Giovanna Liuzzo
AIM: The functional capacity of the immune cells is strongly dependent on their metabolic state and inflammatory responses are characterized by a greater use of glucose in immune cells. This study is aimed to establish the role of glucose metabolism and its players [glucose transporter-1 (GLUT-1) and pyruvate kinase isozyme M2 (PKM2)] in the dysregulation of adaptive immunity and inflammation observed in patients with non-ST-segment elevation myocardial infarction (NSTEMI). METHODS AND RESULTS: We enrolled 248 patients allocated to three groups: NSTEMI patients, chronic coronary syndromes (CCS) patients, healthy subjects (HS)...
December 13, 2022: Cardiovascular Research
https://read.qxmd.com/read/36451821/the-mitochondrial-gene-cmpk2-functions-as-a-rheostat-for-macrophage-homeostasis
#36
JOURNAL ARTICLE
Prabhakar Arumugam, Meghna Chauhan, Thejaswitha Rajeev, Rahul Chakraborty, Kanika Bisht, Mahima Madan, Deepthi Shankaran, Sivaprakash Ramalingam, Sheetal Gandotra, Vivek Rao
In addition to their role in cellular energy production, mitochondria are increasingly recognized as regulators of the innate immune response of phagocytes. Here, we demonstrate that altering expression levels of the mitochondria-associated enzyme, cytidine monophosphate kinase 2 (CMPK2), disrupts mitochondrial physiology and significantly deregulates the resting immune homeostasis of macrophages. Both CMPK2 silenced and constitutively overexpressing macrophage lines portray mitochondrial stress with marked depolarization of their membrane potential, enhanced reactive oxygen species (ROS), and disturbed architecture culminating in the enhanced expression of the pro-inflammatory genes IL1β, TNFα, and IL8...
2022: Frontiers in Immunology
https://read.qxmd.com/read/36420514/mitochondrial-connections-with-immune-system-in-zebrafish
#37
REVIEW
Mariana Abrantes do Amaral, Lais Cavalieri Paredes, Barbara Nunes Padovani, Juliana Moreira Mendonça-Gomes, Luan Fávero Montes, Niels Olsen Saraiva Câmara, Camila Morales Fénero
Mitochondria are organelles commonly associated with adenosine triphosphate (ATP) formation through the oxidative phosphorylation (OXPHOS) process. However, mitochondria are also responsible for functions such as calcium homeostasis, apoptosis, autophagy, and production of reactive oxygen species (ROS) that, in conjunction, can lead to different cell fate decisions. Mitochondrial morphology changes rely on nutrients' availability and the bioenergetics demands of the cells, in a process known as mitochondrial dynamics, which includes both fusion and fission...
December 2021: Fish Shellfish Immunol Rep
https://read.qxmd.com/read/36372132/sociodemographic-lifestyle-and-clinical-characteristics-of-energy-related-depression-symptoms-a-pooled-analysis-of-13-965-depressed-cases-in-8-dutch-cohorts
#38
JOURNAL ARTICLE
Sarah R Vreijling, Marije van Haeringen, Yuri Milaneschi, Floris Huider, Mariska Bot, Najaf Amin, Joline W Beulens, Marijke A Bremmer, Petra J Elders, Tessel E Galesloot, Lambertus A Kiemeney, Hanna M van Loo, H Susan J Picavet, Femke Rutters, Ashley van der Spek, Anne M van de Wiel, Cornelia van Duijn, Edith J M Feskens, Catharina A Hartman, Albertine J Oldehinkel, Jan H Smit, W M Monique Verschuren, Gonneke Willemsen, Eco J C de Geus, Dorret I Boomsma, Brenda W J H Penninx, Femke Lamers, Rick Jansen
BACKGROUND: In a substantial subgroup of depressed patients, atypical, energy-related depression symptoms (e.g. increased appetite/weight, hypersomnia, loss of energy) tend to cluster with immuno-metabolic dysregulations (e.g. increased BMI and inflammatory markers). This clustering is proposed to reflect a more homogeneous depression pathology. This study examines to what extent energy-related symptoms are associated and share demographic, lifestyle and clinical characteristics. METHODS: Data were available from 13,965 participants from eight Dutch cohorts with DSM-5 lifetime major depression assessed by the Lifetime Depression Assessment Self-report (LIDAS) questionnaire...
November 10, 2022: Journal of Affective Disorders
https://read.qxmd.com/read/36334180/the-exploitation-of-enzyme-based-cancer-immunotherapy
#39
REVIEW
Gourav Chandan, Adesh K Saini, Reena Kumari, Sasanka Chakrabarti, Amit Mittal, Anil Kumar Sharma, Reena V Saini
Cancer immunotherapy utilizes the immune system and its wide-ranging components to deliver anti-tumor responses. In immune escape mechanisms, tumor microenvironment-associated soluble factors and cell surface-bound molecules are mainly accountable for the dysfunctional activity of tumor-specific CD8+ T cells, natural killer (NK) cells, tumor associated macrophages (TAMs) and stromal cells. The myeloid-derived suppressor cells (MDSCs) and Foxp3+  regulatory T cells (Tregs), are also key tumor-promoting immune cells...
November 5, 2022: Human Cell
https://read.qxmd.com/read/36302964/hermansky-pudlak-syndrome-type-1-causes-impaired-anti-microbial-immunity-and-inflammation-due-to-dysregulated-immunometabolism
#40
JOURNAL ARTICLE
Athena Cavounidis, Sumeet Pandey, Melania Capitani, Matthias Friedrich, Amy Cross, Lisa Gartner, Dominik Aschenbrenner, Seunghee Kim-Schulze, Ying Ka Lam, Georgina Berridge, Dermot P B McGovern, Benedikt Kessler, Roman Fischer, Paul Klenerman, Joanna Hester, Fadi Issa, Esther A Torres, Fiona Powrie, Bernadette R Gochuico, William A Gahl, Louis Cohen, Holm H Uhlig
Hermansky-Pudlak syndrome (HPS) types 1 and 4 are caused by defective vesicle trafficking. The mechanism for Crohn's disease-like inflammation, lung fibrosis, and macrophage lipid accumulation in these patients remains enigmatic. The aim of this study is to understand the cellular basis of inflammation in HPS-1. We performed mass cytometry, proteomic and transcriptomic analyses to investigate peripheral blood cells and serum of HPS-1 patients. Using spatial transcriptomics, granuloma-associated signatures in the tissue of an HPS-1 patient with granulomatous colitis were dissected...
October 27, 2022: Mucosal Immunology
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