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sinonasal squamous cell carcinoma

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https://www.readbyqxmd.com/read/28646364/sinonasal-malignancies-incidence-and-histological-distribution-in-jamaica-1973-2007
#1
Tracey N Gibson, Dawn P McNaughton, Barrie Hanchard
PURPOSE: To determine the histological distribution and trends in incidence of sinonasal malignancies in Jamaica. METHODS: Cases of all sinonasal malignancies diagnosed between 1973 and 2007 were extracted from the archives of the Jamaica Cancer Registry. Data recorded for each case included age at diagnosis, sex, year of diagnosis, topography, and histology. Data were used to calculate frequencies, age-specific incidence rates, and age-standardized incidence rates (ASRs)...
June 23, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28620639/prevalence-of-human-papilloma-virus-in-sinonasal-papilloma-in-southern-iranian-population
#2
Behnaz Valibeigi, Mohamad Javad Ashraf, Narges Kerdegari, Akbar Safai, Elham Abedi, Bijan Khademi, Negar Azarpira
STATEMENT OF THE PROBLEM: Sinonasal papilloma (SNP) is a rare benign lesion characterized by high recurrence rate and malignant transformation. PURPOSE: This study aimed to investigate the prevalence of human papilloma virus (HPV) infection in these lesions in South of Iran. MATERIALS AND METHOD: In this cross sectional retrospective study, a total of 41 patients, 38 SNP and 3 SNP/Squamous cell carcinoma cases, from 2007 to 2014 were studied...
June 2017: Journal of Dentistry
https://www.readbyqxmd.com/read/28616785/usefulness-of-nkx2-2-immunohistochemistry-for-distinguishing-ewing-sarcoma-from-other-sinonasal-small-round-blue-cell-tumors
#3
Austin McCuiston, Justin A Bishop
NKX2.2 is a new immunohistochemical marker that has been reported to be sensitive and specific for Ewing sarcoma (ES). It has not, however, been investigated specifically in the sinonasal small round blue cell tumor (SRBCT) differential diagnosis which includes many tumors specific to that site. It has also not been investigated in the newly recognized "adamantinoma-like" variant of ES. Immunohistochemistry for NKX2.2 was performed on 170 poorly differentiated sinonasal neoplasms: 73 squamous cell carcinomas (67 poorly differentiated, non-keratinizing, or basaloid types and 6 nasopharyngeal carcinomas), 46 olfactory neuroblastomas, 8 sinonasal undifferentiated carcinomas (SNUCs), 6 melanomas, 7 Ewing sarcomas, 6 SMARCB1-deficient carcinomas, 6 teratocarcinosarcomas, 5 alveolar rhabdomyosarcomas, 4 solid adenoid cystic carcinomas, 4 NK/T cell lymphomas, 3 NUT carcinomas, and 2 small cell carcinomas...
June 14, 2017: Head and Neck Pathology
https://www.readbyqxmd.com/read/28601297/outcomes-of-multimodal-management-for-sinonasal-squamous-cell-carcinoma
#4
Arnaud Paré, Pierre Blanchard, Silvia Rosellini, Anne Aupérin, Philippe Gorphe, Odile Casiraghi, Stéphane Temam, François Bidault, Philippe Page, Frédéric Kolb, François Janot, Antoine Moya Plana
BACKGROUND: Poor prognosis of sinonasal cancers (SNC) is usually due to the non-specific symptoms leading to late diagnosis with locally advanced disease. However, previous prognostic studies were often based on heterogeneous cohorts because of the scarcity of SNC. With squamous cell carcinoma being the main histological subgroup, the study aimed to perform a prognostic analysis on sinonasal squamous cell carcinoma (SNSCC) particularly, and to evaluate the oncological results of a multimodal therapy...
May 12, 2017: Journal of Cranio-maxillo-facial Surgery
https://www.readbyqxmd.com/read/28599459/advances-in-recurrence-and-malignant-transformation-of-sinonasal-inverted-papillomas
#5
Qingjia Sun, Lifeng An, Jun Zheng, Dongdong Zhu
Sinonasal inverted papilloma (SIP) is a benign tumor of the nasal cavity and sinus. SIP is characterized by aggressive malignant transformation and a high rate of recurrence. Inadequate removal of the tumor during surgery is one of the most significant contributors to SIP recurrence. A growing body of evidence suggests that molecular alteration in SIP, including human papilloma virus infections, single nucleotide polymorphisms of key genes, deregulation of signaling pathways and immunological changes, may lead to SIP occurrence and malignant transformation...
June 2017: Oncology Letters
https://www.readbyqxmd.com/read/28586604/orbital-involvement-in-sinonasal-diseases
#6
Zia-Us-Salam Qazi, Sarfraz Latif, Sadia Maqsood Awan
OBJECTIVE: Orbital involvement in sinonasal diseases can present as proptosis, ophthalmoplegia or even as blindness due to optic nerve damage. There are a number of sinonasal diseases which can involve eyes. The purpose of this study was to enlist diagnoses of all the patients with sinonasal disease, in which orbit was also involved unilaterally or bilaterally and to analyse the management strategy and final outcome in all the cases. METHODS: Hundred consecutive patients having orbital symptoms along with sinonasal complaints that presented in ENT department of Shaikh Zayed federal postgraduate medical institute were included in our prospective study...
October 2016: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/28452184/prognostic-survival-value-of-retropharyngeal-lymph-node-involvement-in-sinonasal-tumors-a-retrospective-descriptive-and-exploratory-study
#7
Katharina Gangl, Stefan Nemec, Gabriela Altorjai, Johannes Pammer, Matthaeus Ch Grasl, Boban M Erovic
BACKGROUND: Sinonasal carcinomas are rare. The purpose of this study was for us to present our assessment of the effects of retropharyngeal lymph node involvement at diagnosis on patient outcomes. METHODS: Retropharyngeal lymph node involvement in 36 patients with sinonasal carcinoma was determined by radiology at initial presentation. Clinical outcome, in particular, overall survival (OS) and locoregional control, was assessed by Kaplan-Meier analysis and log-rank testing...
April 28, 2017: Head & Neck
https://www.readbyqxmd.com/read/28369832/a-comprehensive-comparative-analysis-of-treatment-modalities-for-sinonasal-malignancies
#8
Tyler P Robin, Bernard L Jones, Oren M Gordon, Andy Phan, Diana Abbott, Jessica D McDermott, Julie A Goddard, David Raben, Ryan M Lanning, Sana D Karam
BACKGROUND: Sinonasal malignancies are a rare and heterogeneous group of tumors for which there is a paucity of robust data with which to guide management decisions. The authors used the National Cancer Data Base to better understand the presenting characteristics of these tumors and to compare outcomes by treatment modality. METHODS: The National Cancer Data Base was queried for sinonasal malignancies diagnosed between 2004 and 2012. Overall survival was assessed using multivariate analyses and propensity score matching...
April 3, 2017: Cancer
https://www.readbyqxmd.com/read/28328848/clinical-effects-of-p53-overexpression-in-squamous-cell-carcinoma-of-the-sinonasal-tract-a-systematic-meta-analysis-with-prisma-guidelines
#9
Xiaowei Wang, Wei Lv, Fang Qi, Zhiqiang Gao, Hua Yang, Weiqing Wang, Yali Gao
BACKGROUND: The level of p53 protein expression in sinonasal squamous cell carcinoma (SNSCC) has been estimated, but the results remain inconsistent and the point of consensus has not been reached. This study was first determined to evaluate the clinical effects of p53 expression in SCC of the sinonasal tract. METHODS: According to the preferred reporting items for systematic reviews and meta-analyses (PRISMA) statement criteria, the potential literature was searched from diverse databases...
March 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28291122/smarcb1-ini-1-deficient-sinonasal-carcinoma-a-series-of-39-cases-expanding-the-morphologic-and-clinicopathologic-spectrum-of-a-recently-described-entity
#10
Abbas Agaimy, Arndt Hartmann, Cristina R Antonescu, Simion I Chiosea, Samir K El-Mofty, Helene Geddert, Heinrich Iro, James S Lewis, Bruno Märkl, Stacey E Mills, Marc-Oliver Riener, Thomas Robertson, Ann Sandison, Sabine Semrau, Roderick H W Simpson, Edward Stelow, William H Westra, Justin A Bishop
To more fully characterize the clinical and pathologic spectrum of a recently described tumor entity of the sinonasal tract characterized by loss of nuclear expression of SMARCB1 (INI1), we analyzed 39 SMARCB1-deficient sinonasal carcinomas collected from multiple medical centers. The tumors affected 23 males and 16 females with an age range of 19 to 89 years (median, 52). All patients presented with locally advanced disease (T3, n=5; T4, n=27) involving the sinuses (mainly ethmoid) with variable involvement of the nasal cavity...
April 2017: American Journal of Surgical Pathology
https://www.readbyqxmd.com/read/28271500/outcomes-of-hpv-related-nasal-squamous-cell-carcinoma
#11
Naweed Chowdhury, Sameer Alvi, Kyle Kimura, Ossama Tawfik, Pradip Manna, David Beahm, Ann Robinson, Spencer Kerley, Larry Hoover
BACKGROUND: Human papilloma virus (HPV) infection has been shown to play an integral role in the development and prognosis of various head and neck cancers. Generational changes in sexual behavior may have led to an increased incidence of positivity in recent years. HPV positivity in both benign and malignant lesions of the sinonasal cavities has been shown in previous studies (estimates range from 20%-30% for malignancy). We intend to investigate if HPV positivity affected survival outcomes in our patient cohort...
March 8, 2017: Laryngoscope
https://www.readbyqxmd.com/read/28258684/-inverted-papilloma-of-the-nasal-cavity-a-case-report
#12
Jadwiga Muszalska, Tomasz Zatoński
Inverted papilloma is a rare, benign sinonasal tumor. Its etiology is the most likely related to HPV infection. Inverted papilloma originates from the ciliated respiratory epithelium, typically from the lateral nasal wall. The tumor is characterized by endophytic growth inwards the stroma with adjacent tissues destruction. The clinical symptoms are non-specific, such as: unilateral obstruction of the nasal duct, rhinorrhoea, epistaxis and anosmia. The treatment consists in a complete surgical excision of the tumor...
February 20, 2017: Polski Merkuriusz Lekarski: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/28255033/mri-based-texture-analysis-to-differentiate-sinonasal-squamous-cell-carcinoma-from-inverted-papilloma
#13
S Ramkumar, S Ranjbar, S Ning, D Lal, C M Zwart, C P Wood, S M Weindling, T Wu, J R Mitchell, J Li, J M Hoxworth
BACKGROUND AND PURPOSE: Because sinonasal inverted papilloma can harbor squamous cell carcinoma, differentiating these tumors is relevant. The objectives of this study were to determine whether MR imaging-based texture analysis can accurately classify cases of noncoexistent squamous cell carcinoma and inverted papilloma and to compare this classification performance with neuroradiologists' review. MATERIALS AND METHODS: Adult patients who had inverted papilloma or squamous cell carcinoma resected were eligible (coexistent inverted papilloma and squamous cell carcinoma were excluded)...
March 2, 2017: AJNR. American Journal of Neuroradiology
https://www.readbyqxmd.com/read/28207194/clinical-outcomes-of-sinonasal-squamous-cell-carcinomas-based-on-tumor-etiology
#14
Carol H Yan, Jason G Newman, David W Kennedy, James N Palmer, Nithin D Adappa
BACKGROUND: Squamous cell carcinoma (SCC) of the sinonasal cavity is a rare entity that arises as either de-novo tumors or from inverted papillomas (IPs). In this study we evaluate and compare oncologic outcomes of sinonasal SCCs based on their etiology and treatment strategy. METHODS: This investigation was a single-center, retrospective review comparing de-novo SCCs (n = 28) and those associated with IPs (n = 38) resected during the period from 2000 to 2015. Demographic and tumor data, surgical approach, recurrence, and clinical outcomes were analyzed...
May 2017: International Forum of Allergy & Rhinology
https://www.readbyqxmd.com/read/28060373/small-round-blue-cell-tumors-of-the-sinonasal-tract-a-differential-diagnosis-approach
#15
Lester Dr Thompson
One of the most challenging diagnostic categories within tumors of the sinonasal tract is the small round blue cell tumors. Biopsies are usually small and limited, resulting in considerable diagnostic difficulty for practicing surgical pathologists. These tumors share several overlapping histologic and immunophenotypic findings while also showing considerable variation within and between cases. Specific tumor site of origin, imaging findings, and clinical findings must be combined with the histology and pertinent ancillary studies if the correct diagnosis is to be reached...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28060369/virus-associated-neoplasms-of-the-nasopharynx-and-sinonasal-tract-diagnostic-problems
#16
John Kc Chan
A significant fraction of nasopharyngeal and sinonasal tumors are associated with Epstein-Barr virus (EBV) or human papillomavirus (HPV). Nasopharyngeal carcinoma (NPC) and extranodal NK/T-cell lymphoma harbor EBV in practically all cases, although a small proportion of cases of the former harbor HPV. Sinonasal inverted papillomas harbor HPV in about 25% of cases. Sinonasal squamous cell carcinomas harbor transcriptionally active HPV in about 20% of cases, and limited data suggest that this subset has a better prognosis than the HPV-negative subset...
January 2017: Modern Pathology: An Official Journal of the United States and Canadian Academy of Pathology, Inc
https://www.readbyqxmd.com/read/28050382/intestinal-type-adenocarcinoma-from-inverted-papilloma-a-rare-recurrence
#17
Garima Singh, Meeta Singh, Mansi Chandana, Sompal Singh, Namrata Nargotra
Inverted Papilloma (IP) is an uncommon and locally aggressive benign tumour of sinonasal region, which tends to recur after surgical resection. Most tumours are confined to the lateral nasal wall and sinuses, with maxillary sinus being most commonly affected and a male preponderance. It has a known association with in situ and invasive carcinomas with a <10% rate of malignant transformation. Most common association has been seen with squamous cell carcinoma and extremely rare association with adenocarcinoma and small cell carcinoma...
November 2016: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28035703/human-papillomavirus-related-carcinoma-with-adenoid-cystic-like-features-of-the-sinonasal-tract-clinical-and-morphological-characterization-of-six-new-cases
#18
Simon Andreasen, Justin A Bishop, Thomas van Overeem Hansen, William H Westra, Anders Bilde, Christian von Buchwald, Katalin Kiss
AIMS: Human papillomavirus (HPV) is known as causative for squamous cell carcinoma (SCC) of the oropharynx, but is also found not infrequently in carcinomas of the sinonasal tract. Recently, a subset of these carcinomas was recognized to harbour HPV33 and have a significant morphological overlap with adenoid cystic carcinoma (ACC), a rare and aggressive carcinoma originating in the minor salivary glands. Termed 'HPV-related carcinoma with ACC-like features', only nine cases have been reported...
December 30, 2016: Histopathology
https://www.readbyqxmd.com/read/28034680/implementation-of-intensity-modulated-radiotherapy-for-head-and-neck-cancers-in-routine-practice
#19
C Bednarek, T V F Nguyen, M Puyraveau, É Bonnet, N Lescut, C Azélie, J Miny, O Mauvais, T Maurina, F Tochet, J-F Bosset, J Thariat, X S Sun
PURPOSE: To report on patterns of relapse following implementation of intensity-modulated radiotherapy and subsequent changes in practice in a tertiary care centre. PATIENTS AND METHODS: Between 2008 and 2011, 188 consecutive patients (mean age 59 years old) received intensity-modulated radiotherapies with curative intent for squamous cell carcinomas of the oral cavity (17.5%), oropharynx (43%), hypopharynx (21%), larynx (14%), sinonasal cavities (6%), nasopharynx (1...
February 2017: Cancer Radiothérapie: Journal de la Société Française de Radiothérapie Oncologique
https://www.readbyqxmd.com/read/27993194/sinonasal-papillomas-in-a-private-referral-otorhinolaryngology-centre-review-of-22-years-experience
#20
Aderito de Sousa Fontes, Minaret Sandrea Jiménez, Nelson Urdaneta Lafée, Perfecto A Abreu Durán, Liwven E Quintana Páez, Andreina Carmina de Sousa de Abreu
OBJECTIVES: To evaluate the clinical presentation, treatment outcome and follow-up of all patients managed with sinonasal papillomas (SP), at a tertiary private otorhinolaryngology centre in Caracas (Venezuela). MATERIAL AND METHODS: We reviewed 94 patients with SP that were treated at our otolaryngology center, from July 1st 1993 to June 31st 2015. The demographic data, clinical features, radiological findings, anatomical origin, disease extension into the adjacent structures, surgical approaches performed, histopathology outcomes, recurrent risk, malignant transformation rate and coadjuvant therapies were assessed...
December 16, 2016: Acta Otorrinolaringológica Española
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