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Vitamin D AND statin

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https://www.readbyqxmd.com/read/29694950/is-sclerostin-level-associated-with-cardiovascular-diseases-in-hemodialysis-patients
#1
Gokce Kundakci Gelir, Sule Sengul, Gokhan Nergizoglu, Sehsuvar Ertürk, Neval Duman, Sim Kutlay
BACKGROUND/AIMS: The objective of this study is to evaluate the relation between sclerostin, arterial stiffness, and cardiovascular events (CVE) in hemodialysis patients (HD). METHODS: Sclerostin level and carotid-femoral pulse wave velocity (PWV) in 97 HD patients and sclerostin level in 40 controls were measured. RESULTS: Sclerostin level was significantly higher in patients than in controls. Sclerostin associated positively with age, male gender, cardiovascular disease, statin use, BMI, and PWV while negatively with alkaline phosphatase, parathormone (PTH), Kt/V, cinacalcet and vitamin D use in univariable correlation analyses...
April 25, 2018: Blood Purification
https://www.readbyqxmd.com/read/29684661/effects-of-vitamin-d-supplementation-on-adherence-to-and-persistence-with-long-term-statin-therapy-secondary-analysis-from-the-randomized-double-blind-placebo-controlled-vida-study
#2
Zhenqiang Wu, Carlos A Camargo, Kay-Tee Khaw, Debbie Waayer, Carlene M M Lawes, Les Toop, Robert Scragg
BACKGROUND AND AIMS: Long-term statin use increases survival. However, the adherence to and persistence with statin use are challenging and this influences the success of statin treatment. Our aim was to explore if monthly vitamin D supplementation (100,000-IU) improves the adherence to and persistence with long-term statin use in older adults. METHODS: We conducted a secondary analysis of a trial comparing data on dispensed statin prescriptions, between participants allocated to vitamin D supplementation or placebo, for those taking statin therapy...
April 7, 2018: Atherosclerosis
https://www.readbyqxmd.com/read/29684218/what-is-the-evidence-for-a-role-for-diet-and-nutrition-in-osteoarthritis
#3
Sally Thomas, Heather Browne, Ali Mobasheri, Margaret P Rayman
As current treatment options in OA are very limited, OA patients would benefit greatly from some ability to self-manage their condition. Since diet may potentially affect OA, we reviewed the literature on the relationship between nutrition and OA risk or progression, aiming to provide guidance for clinicians. For overweight/obese patients, weight reduction, ideally incorporating exercise, is paramount. The association between metabolic syndrome, type-2 diabetes and OA risk or progression may partly explain the apparent benefit of dietary-lipid modification resulting from increased consumption of long-chain omega-3 fatty-acids from oily fish/fish oil supplements...
May 1, 2018: Rheumatology
https://www.readbyqxmd.com/read/29643908/lack-of-association-of-statin-use-with-vitamin-d-levels-in-a-hospital-based-population-of-type-2-diabetes-mellitus-patients
#4
Khalida Iqbal, Najmul Islam, Iqbal Azam, Naseema Mehboobali, Mohammad Perwaiz Iqbal
Objective: To investigate the relationship of statins (drug given to reduce serum levels of LDL-cholesterol) on vitamin D levels of Pakistani type 2 diabetes mellitus (DM) patients in a hospital in Karachi. Methods: In a cross-sectional survey, 312 consecutive patients with type 2 DM (219 males and 93 females, age 22-70 years) were recruited with informed consent. A questionnaire was administered to find out whether they were statin users or non-users. Serum was analyzed for concentrations of 25(OH) vitamin D [25(OH)D] and other related biomarkers such as serum cholesterol, triglycerides, HDL-cholesterol, LDL-cholesterol, phosphate and calcium using kit methods...
January 2018: Pakistan Journal of Medical Sciences Quarterly
https://www.readbyqxmd.com/read/29578928/negative-correlation-of-high-density-of-lipoprotein-cholesterol-and-bone-mineral-density-in-postmenopausal-iranian-women-with-vitamin-d-deficiency
#5
Zhila Maghbooli, Leila Khorrami-Nezhad, Elham Adabi, Majid Ramezani, Effat Asadollahpour, Farideh Razi, Mohammadtaher Rezanezhad
OBJECTIVE: The aim of the study was to investigate the association between high-density lipoprotein (HDL) and bone status taking into account serum vitamin D levels in postmenopausal Iranian women. METHODS: During January 2015 and February 2016, a total of 488 postmenopausal Iranian women participated in this cross-sectional study, all of whom were not taking osteoporosis medication and were not suffering from any chronic disorder. Dual X-ray absorptiometry was used to assess bone mineral density (BMD) of the total hip, femoral neck, and lumbar vertebrae (L2-L4)...
March 19, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29557847/negative-correlation-of-high-density-of-lipoprotein-cholesterol-and-bone-mineral-density-in-postmenopausal-iranian-women-with-vitamin-d-deficiency
#6
Zhila Maghbooli, Leila Khorrami-Nezhad, Elham Adabi, Majid Ramezani, Effat Asadollahpour, Farideh Razi, Mohammadtaher Rezanezhad
OBJECTIVE: The aim of the study was to investigate the association between high-density lipoprotein (HDL) and bone status taking into account serum vitamin D levels in postmenopausal Iranian women. METHODS: During January 2015 and February 2016, a total of 488 postmenopausal Iranian women participated in this cross-sectional study, all of whom were not taking osteoporosis medication and were not suffering from any chronic disorder. Dual X-ray absorptiometry was used to assess bone mineral density (BMD) of the total hip, femoral neck, and lumbar vertebrae (L2-L4)...
March 19, 2018: Menopause: the Journal of the North American Menopause Society
https://www.readbyqxmd.com/read/29420305/effect-of-slco1b1-gene-polymorphisms-and-vitamin-d-on-statin-induced-myopathy
#7
Baraa Alghalyini, Said El Shamieh, Ali Salami, Sophie Visvikis Siest, Hana M Fakhoury, Rajaa Fakhoury
Background Statin therapy used to lower cholesterol levels results in a substantial reduction in cardiovascular complications. Previous observations in different ethnic populations showed that rs2306283A>G, p.Asn130Asp and rs4149056T>C, p.Val174Ala in solute carrier organic anion transporter 1B1 (SLCO1B1) gene encoding the organic transporter protein may be responsible for statin uptake, thus explaining the majority of statin-associated symptoms. In addition to the genetic component, vitamin D (vit D) deficiency is common in Saudi Arabia and worldwide and may cause muscle dysfunction and ache...
March 28, 2018: Drug Metabolism and Personalized Therapy
https://www.readbyqxmd.com/read/29388528/completed-audit-cycle-to-explore-the-use-of-the-stopp-start-toolkit-to-optimise-medication-in-psychiatric-in-patients-with-dementia
#8
Victor M Aziz, Natalie Hill, Sugandha Kumar
Aims and method To explore the use of the STOPP/START toolkit in older psychiatric in-patients with dementia. Clinical records and current drug charts were reviewed against STOPP/START criteria for all in-patients (n = 86) on six specialist dementia wards. RESULTS: Benzodiazepines, antipsychotics and opiates were most commonly prescribed inappropriately. The most common unprescribed medication groups were statins, calcium supplements and vitamin D supplements. There was an overall reduction of 7% in comorbidities and 8% in the number of prescriptions...
February 2018: BJPsych Bulletin
https://www.readbyqxmd.com/read/29344438/new-therapeutic-approaches-in-obesity-and-metabolic-syndrome-associated-with-polycystic-ovary-syndrome
#9
REVIEW
Fatima Saleem, Syed W Rizvi
Polycystic ovary syndrome (PCOS) is a pathophysiological disorder affecting reproductive and metabolic indices. PCOS is commonly associated with a high prevalence of insulin resistance and obesity; this association carries an increased risk of developing metabolic syndrome, type 2 diabetes mellitus (T2DM), and cardiovascular disease. Guidelines recommend lifestyle modification, metformin, hormonal contraceptives (HCs), and bariatric surgery as the main treatment options in obese patients with PCOS. Studies are being conducted to test the efficacy of existing treatment options as well as to discover new therapies...
November 13, 2017: Curēus
https://www.readbyqxmd.com/read/29331793/moderate-dose-simvastatin-therapy-potentiates-the-effect-of-vitamin-d-on-thyroid-autoimmunity-in-levothyroxine-treated-women-with-hashimoto-s-thyroiditis-and-vitamin-d-insufficiency
#10
Robert Krysiak, Witold Szkróbka, Bogusław Okopień
BACKGROUND: Vitamin D preparations reduce titers of thyroid antibodies in women with autoimmune thyroiditis. The same effect was induced by high-dose, but not moderate-dose-, statin therapy. No previous study has investigated the impact of concomitant treatment with a statin and vitamin D on thyroid autoimmunity. METHODS: The study included three matched groups of women with Hashimoto's thyroiditis and low vitamin D status. Groups B (n=19) and C (n=20) were treated with vitamin D (2000 IU daily)...
February 2018: Pharmacological Reports: PR
https://www.readbyqxmd.com/read/29311132/the-epidemiology-of-prostate-cancer
#11
Claire H Pernar, Ericka M Ebot, Kathryn M Wilson, Lorelei A Mucci
Prostate cancer is a major cause of disease and mortality among men, and each year 1.6 million men are diagnosed with and 366,000 men die of prostate cancer. In this review, we discuss the state of evidence for specific genetic, lifestyle, and dietary factors associated with prostate cancer risk. Given the biological heterogeneity of this cancer, we focus on risk factors for advanced or fatal prostate cancer. First, we provide descriptive epidemiology statistics and patterns for prostate cancer incidence and mortality around the world...
January 8, 2018: Cold Spring Harbor Perspectives in Medicine
https://www.readbyqxmd.com/read/29239815/provider-recommendations-for-patient-reported-muscle-symptoms-on-statin-therapy-insights-from-the-understanding-statin-use-in-america-and-gaps-in-patient-education-survey
#12
Terry A Jacobson, Abdullah Khan, Kevin C Maki, Eliot A Brinton, Jerome D Cohen
BACKGROUND: Statin-associated muscle symptoms are reported by 10% to 29% of patients in clinical practice and are a major determinant of statin nonadherence, discontinuation, and switching. Little is known about what advice patients receive from their providers when dealing with these symptoms. OBJECTIVE: The objective of the study was to assess patient's reports of provider advice when experiencing new or worsened muscle symptoms while taking a statin. METHODS: Data were analyzed from the Understanding Statin Use in America and Gaps in Education survey, a self-administered internet-based survey of 10,138 adults with a reported history of high cholesterol and statin use...
January 2018: Journal of Clinical Lipidology
https://www.readbyqxmd.com/read/29221946/-facing-a-dilemma-in-elderly-complex-and-vulnerable-patients-to-stop-or-not-to-stop-prevention
#13
Laura Llobet Vila, Josep Maria Manresa Domínguez, José Manuel Carmona Segado, Alícia Franzi Sisó, Rosa Vallès Balasch, Isabel Martínez Díaz
OBJECTIVES: 1-To know the preventive prescription (statin, antiplatelet drugs, bisphosphonates, calcium and vitamin D and Vit B12) of elderly patients previously identified as a CCD (with a complex chronic disease) and ACD (with advanced chronic disease and lifetime expectancy of less than 12 months) who died during 2015. 2-To assess the correct indication of Proton Pump Inhibitors (PPI) to determine potentially avoidable medication. DESIGN: Retrospective observational study...
December 5, 2017: Atencion Primaria
https://www.readbyqxmd.com/read/29164916/age-and-gender-differences-in-medical-adherence-after-myocardial-infarction-women-do-not-receive-optimal-treatment-the-netherlands-claims-database
#14
Daniëlle C Eindhoven, Alexander D Hilt, Thomas C Zwaan, Martin J Schalij, C Jan Willem Borleffs
Background Following myocardial infarction, medication is, besides lifestyle interventions, the cornerstone treatment to improve survival and minimize the occurrence of new cardiovascular events. Still, data on nationwide medication adherence are scarce. This study assesses medical adherence during one year following myocardial infarction, stratifying per type of infarct, age and gender. Design Retrospective cohort study. Methods In The Netherlands, all inhabitants are by law obliged to have health insurance and all claims data are centrally registered...
January 2018: European Journal of Preventive Cardiology
https://www.readbyqxmd.com/read/29123386/geroprotectors-as-a-therapeutic-strategy-for-copd-where-are-we-now
#15
REVIEW
Joanna Miłkowska-Dymanowska, Adam J Białas, Joanna Makowska, Aleksandra Wardzynska, Paweł Górski, Wojciech J Piotrowski
Although current therapies in chronic obstructive pulmonary disease (COPD) improve the quality of life, they do not satisfactorily reduce disease progression or mortality. There are still many gaps in knowledge about the cellular, molecular, and genetic mechanisms contributing to pathobiology of this disease. However, increasing evidence suggests that accelerated aging, chronic systemic inflammation, and oxidative stress play major roles in pathogenesis in COPD, thus opening new opportunities in therapy. Therefore, the aim of our review was to describe and discuss some of the most widely used therapeutics that affect the root cause of aging and oxidative stress (metformin, melatonin, sirolimus, statins, vitamin D, and testosterone) in context of COPD therapy...
2017: Clinical Interventions in Aging
https://www.readbyqxmd.com/read/29110598/sirt1-as-a-therapeutic-target-in-diabetic-complications
#16
Justyna Strycharz, Żaneta Rygielska, Ewa Świderska, Józef Drzewoski, Janusz Szemraj, Leszek Szmigiero, Agnieszka Śliwińska
Background SIRT1 is an epigenetic enzyme involved in histone and non-histone protein deacetylation. It acts primarily as a metabolic sensor, which responses to changing energy status by deacetylating crucial transcription factors and cofactors. In this way, SIRT1 regulates mitochondrial function and biogenesis, oxidative stress, inflammation, apoptosis and cellular senescence. Disturbance of all of these phenomena promotes the pathogenesis of diabetic complications. These disorders are inseparably connected with chronic hyperglycemia, which possesses a strong epigenetic determinant...
November 6, 2017: Current Medicinal Chemistry
https://www.readbyqxmd.com/read/29108191/-an-interpretation-of-the-aasld-practice-guideline-on-the-diagnosis-and-management-of-nonalcoholic-fatty-liver-disease-in-2017
#17
Y M Nan, N Fu, W C Li, L L Kong, X W Yuan, S Y Zhang, L D Liu, Y Lu, L Y Cui
The American Association for the Study of Liver Diseases (AASLD) updated and published the Practice Guidance for the Diagnosis and Management of Nonalcoholic Fatty Liver Disease (NAFLD) in July 2017, which provides recommendations for the accurate diagnosis, treatment, and effective prevention of NAFLD. Related metabolic diseases should be considered during the initial evaluation of patients suspected of NAFLD. Noninvasive diagnostic techniques including transient elastography, magnetic resonance elastography, and serum biochemical models should be used to evaluate the development and progression of liver fibrosis in patients with NAFLD...
September 20, 2017: Zhonghua Gan Zang Bing za Zhi, Zhonghua Ganzangbing Zazhi, Chinese Journal of Hepatology
https://www.readbyqxmd.com/read/29099100/association-of-vitamin-d-deficiency-with-coronary-artery-disease-in-mexican-population-genetics-of-atherosclerotic-disease-gea-study
#18
Fabiola López-Bautista, Carlos Posadas-Romero, Guillermo Cardoso-Saldaña, Juan Gabriel Juárez-Rojas, Aida Medina-Urrutia, Nonanzit Pérez-Hernández, José Manuel Rodríguez-Pérez, Gilberto Vargas-Alarcón, Rosalinda Posadas-Sánchez
Objective: To investigate the independent association between vitamin D deficiency (VDD) and coronary artery disease (CAD) in Mexican adult population. Method: Matched case-control study. Data cardiovascular on risk factors, medication use, physical activity, alcohol use, smoking and vitamin D consumption were obtained. Biochemical variables, anthropometric and blood pressure were measured. 25(OH)D was quantified by chemiluminescence. Results: We studied 250 patients with established CAD and 250 age-gender-body mass index (BMI) matched control subjects, with a mean age of 53 ± 6...
2017: Gaceta Médica de México
https://www.readbyqxmd.com/read/29067242/impact-of-vitamin-d-status-on-statin-induced-myopathy
#19
Krista D Riche, Justin Arnall, Kristin Rieser, Honey E East, Daniel M Riche
INTRODUCTION: There is a multitude of evidence supporting the benefit of statin use in cardiovascular disease; however, statin-induced myopathy is a major reason for statin discontinuation and non-adherence. Vitamin D deficiency has been independently associated with muscle weakness and severe myopathy, and may be a confounder for statin-induced myopathies. Since there is no consensus on a treatment course of action for statin-induced myopathy, investigation into potential confounders to elucidate the dynamics of statin-induced myopathy is warranted...
December 2016: Journal of Clinical & Translational Endocrinology
https://www.readbyqxmd.com/read/28980606/-modern-conception-of-the-pathogenesis-of-neurodegenerative-diseases-and-therapeutic-strategy
#20
I V Litvinenko, I V Krasakov, G N Bisaga, D I Skulyabin, I D Poltavsky
Here we discuss the pathogenesis of the inflammatory and degenerative nervous system disorders on the example of Parkinson's disease, Alzheimer's disease, multiple sclerosis. Common mechanisms of neurodegeneration in these diseases are reviewed. The role of neurodegeneration as the main process leading to the resistant disability of patients with multiple sclerosis is discussed. The authors consider a contribution of inflammatory process and chronic infection to the manifestation and progressing of a neurodegenerative disease and discuss the use of treatment not usually indicated including interferon, anti-inflammatory drugs, statin, vitamin D, monoclonal antibodies, correction of the intestinal microbiota in Parkinson's disease and Alzheimer's disease...
2017: Zhurnal Nevrologii i Psikhiatrii Imeni S.S. Korsakova
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