Yusuke Matoba, Dominique T Zarrella, Venkatesh Pooladanda, Maryam Azimi Mohammadabadi, Eugene Kim, Shaan Kumar, Mengyao Xu, Xingping Qin, Lauren J Ray, Kyle M Devins, Raj Kumar, Artem Kononenko, Eric Eisenhauer, Irva E Veillard, Wataru Yamagami, Sarah J Hill, Kristopher A Sarosiek, Oladapo O Yeku, David R Spriggs, Bo R Rueda
BACKGROUND: Uterine serous cancer (USC) comprises around 10% of all uterine cancers. However, USC accounts for approximately 40% of uterine cancer deaths, which is attributed to tumor aggressiveness and limited effective treatment. Galectin 3 (Gal3) has been implicated in promoting aggressive features in some malignancies. However, Gal3's role in promoting USC pathology is lacking. METHODS: We explored the relationship between LGALS3 levels and prognosis in USC patients using TCGA database, and examined the association between Gal3 levels in primary USC tumors and clinical-pathological features...
March 4, 2024: British Journal of Cancer