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Nephrosclerosis

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https://www.readbyqxmd.com/read/27827846/age-related-renal-microvascular-changes-evaluation-by-three-dimensional-digital-imaging-of-the-human-renal-microcirculation-using-virtual-microscopy
#1
Noriko Uesugi, Yoshihito Shimazu, Kazunori Kikuchi, Michio Nagata
The renal microvasculature is targeted during aging, sometimes producing chronic kidney disease (CKD). Overdiagnosis of CKD in older persons is concerning. To prevent it, a new concept of "healthy aging" is arising from a healthy renal donor study. We investigated the renal microcirculatory changes of three older persons and compared them with that of one patient with nephrosclerosis using a three-dimensional (3D) reconstruction technique that we previously developed. This method uses a virtual slide system and paraffin-embedded serial sections of surgical material that was double-immunostained by anti-CD34 and anti-α smooth muscle actin (SMA) antibodies for detecting endothelial cells and medial smooth muscle cells, respectively...
November 2, 2016: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/27784849/hyperuricemia-as-a-predictive-marker-for-progression-of-nephrosclerosis-clinical-assessment-of-prognostic-factors-in-biopsy-proven-arterial-arteriolar-nephrosclerosis
#2
Kumiko Momoki, Hiroshi Kataoka, Takahito Moriyama, Toshio Mochizuki, Kosaku Nitta
AIM: The influence of serum urate on kidney disease is attracting attention, but the effects of uric acid (UA) on nephrosclerosis have not been elucidated. METHODS: We reviewed data from 45 patients diagnosed with arterial/arteriolar nephrosclerosis. The renal outcomes of the arterial/arteriolar nephrosclerosis patients were assessed by performing logistic and Cox regression analyses. A Kaplan-Meier analysis was used to evaluate the impact of hyperuricemia (HU) on kidney survival...
October 26, 2016: Journal of Atherosclerosis and Thrombosis
https://www.readbyqxmd.com/read/27753815/ssa-05-2-hypertension-and-kidney-complication-in-africa
#3
Solomon Kadiri
Hypertension prevalence rates in most urbanized areas of Africa range from 20-30%, with a recent systematic review reporting 16.2% for sub-Saharan Africa. These rates are lower than those in the West but the age standardized rates are higher than in other regions of the world. The attendant morbidity and mortality are disproportionately high. For example, failure of nocturnal dipping and microalbuminuria, predictive of vascular disease, occur relatively early in the course of hypertension and predispose to early vascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27678298/study-of-the-kidney-tumor-parenchymal-interface-after-neoadjuvant-treatment-with-axitinib-for-locally-advanced-clear-cell-renal-cell-carcinoma-matched-analysis-from-a-phase-ii-trial
#4
Fumi Kawakami, Priya Rao, Pheroze Tamboli, Christopher G Wood, Jose A Karam
PURPOSE: The aim of this study was to evaluate histological changes in the tumor-parenchymal interface in clear cell renal cell carcinoma after neoadjuvant axitinib treatment. MATERIALS AND METHODS: We obtained clinical and pathology materials from 23 patients with clear cell renal cell carcinoma treated with neoadjuvant axitinib in a phase II clinical trial and from 23 matched patients with clear cell renal cell carcinoma who underwent upfront surgery. Histology of the tumor pseudocapsule and the peritumor kidney parenchymal change was evaluated and compared between the 2 cohorts...
September 25, 2016: Journal of Urology
https://www.readbyqxmd.com/read/27643378/ssa-05-2-hypertension-and-kidney-complication-in-africa
#5
Solomon Kadiri
Hypertension prevalence rates in most urbanized areas of Africa range from 20-30%, with a recent systematic review reporting 16.2% for sub-Saharan Africa. These rates are lower than those in the West but the age standardized rates are higher than in other regions of the world. The attendant morbidity and mortality are disproportionately high. For example, failure of nocturnal dipping and microalbuminuria, predictive of vascular disease, occur relatively early in the course of hypertension and predispose to early vascular disease...
September 2016: Journal of Hypertension
https://www.readbyqxmd.com/read/27598487/-survival-of-older-patients-starting-hemodialysis-in-chile
#6
Álvaro Ríos, Patricia Herrera, Álvaro Morales, Enrique Reynolds, María Belén Fernández, Fernando González
UNLABELLED: The proportion of older people with end stage renal disease is increasing. Their prognosis is characterized by a high mortality and poor quality of life. AIM: To analyze the survival of patients starting chronic hemodialysis (CHD) according to their age. MATERIAL AND METHODS: Patients admitted to CHD in the East Metropolitan Health Service of Santiago in a 2-year period were analyzed. Four age groups were created, separating patients older than 70 years in a special group...
June 2016: Revista Médica de Chile
https://www.readbyqxmd.com/read/27594733/urinary-lysosomal-enzyme-activities-and-albuminuria-in-ghanaian-patients-with-type-2-diabetes-mellitus
#7
Henry Asare-Anane, Felix Twum, Emmanuel Kwaku Ofori, Erving L Torgbor, Seth D Amanquah, Charlotte Osafo
Renal tubular lysosomal enzyme activities like alanine aminopeptidase (AAP) and N-acetyl-β-D-glucosaminidase (NAG) have been shown to increase in patients developing diabetic nephropathy and nephrosclerosis. This study aimed to determine the activities of N-acetyl-β-D-glucosaminidase and alanine aminopeptidase and albumin concentration in urine samples of patients with type 2 diabetes. One hundred and thirty (65 type 2 diabetic and 65 nondiabetic) subjects participated in this study. Blood samples were drawn for measurements of fasting blood glucose, albumin (Alb), lipids, and creatinine (Cr)...
2016: Disease Markers
https://www.readbyqxmd.com/read/27569942/safety-of-monitoring-viral-and-liver-function-markers-in-patients-with-prior-resolved-hepatitis-b-infection-after-kidney-transplantation
#8
H Maekawa, M Yazawa, K Koitabashi, N Imai, H Kawarazaki, R Nakazawa, H Sasaki, T Chikaraishi, Y Shibagaki
BACKGROUND: Hepatitis B virus (HBV) infection is a risk factor of mortality in kidney transplant recipients. However, information on the risk of HBV reactivation in kidney recipients with prior resolved HBV infection is limited. This study aimed to evaluate the safety of simply monitoring viral and liver markers in living donor kidney transplantation (LDKT) recipients with prior resolved HBV infection. METHODS: We retrospectively examined the clinical records of LDKT recipients...
July 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27458566/skin-disorders-in-peritoneal-dialysis-patients-an-underdiagnosed-subject
#9
Meltem Gursu, Sami Uzun, Derya Topcuoğlu, Leyli Kadriye Koc, Lamiye Yucel, Abdullah Sumnu, Egemen Cebeci, Oktay Ozkan, Ahmet Behlul, Leyla Koc, Savas Ozturk, Rumeyza Kazancioglu
AIM: To examine all skin changes in peritoneal dialysis (PD) patients followed up in our unit. METHODS: Patients on PD program for at least three months without any known chronic skin disease were included in the study. Patients with already diagnosed skin disease, those who have systemic diseases that may cause skin lesions, patients with malignancies and those who did not give informed consent were excluded from the study. All patients were examined by the same predetermined dermatologist with all findings recorded...
July 6, 2016: World Journal of Nephrology
https://www.readbyqxmd.com/read/27305749/-the-spectrum-of-renal-disease-in-kidney-biopsies-of-diabetic-patients-a-single-center-experience
#10
Yael Einbinder, Debbie J Goodman, Isabelle Haggiag, Tania Zahavi, Sydney Benchetrit
BACKGROUND: Kidney biopsies are not routinely performed for diabetic patients with chronic kidney disease. However in some cases, a biopsy is carried out to exclude other treatable Prolonged duration of diabetes, insulin therapies and presence of diabetic retinopathy were associated with a greater likelihood of DN. The high prevalence of NDRD in our population emphasizes the judicious use of kidney biopsy in diabetic patients. e renal diseases. The prevalence and the nature of non diabetic renal disease (NDRD) among diabetic patients in Israel have not yet been evaluated...
March 2016: Harefuah
https://www.readbyqxmd.com/read/27296267/-secondary-monoclonal-gammopathy-after-bone-marrow-autotransplantation-as-a-cause-of-worse-renal-function-in-light-chain-immunoglobulin-deposition-disease
#11
I G Rekhtina, L P Mendeleeva, E S Stolyarevich, I V Gal'tseva, P E Povilaitite, L S Biryukova
The paper describes a clinical case of a female woman with nephropathy due to light chain deposition disease caused by secretion of κ Bence-Jones protein. Complete immunochemical remission was achieved after induction therapy using a bortezomib + cyclophosphamide + dexamethasone regimen. Renal function remained unchanged (glomerular filtration rate 16 ml/min), there was a reduction in proteinuria from 5.8 to 2.6 g/day. High-dose melphalan (200 mg/m2) chemotherapy with peripheral blood stem cell autotransplantation was performed as consolidation of remission...
2016: Terapevticheskiĭ Arkhiv
https://www.readbyqxmd.com/read/27283488/why-when-and-how-should-immunosuppressive-therapy-considered-in-patients-with-immunoglobulin-a-nephropathy
#12
REVIEW
F M Rasche, F Keller, W G Rasche, S Schiekofer, A Boldt, U Sack, J Fahnert
IgA nephropathy (IgAN) is the most common primary glomerulonephritis worldwide. Lifelong mesangial deposition of IgA1 complexes subsist inflammation and nephron loss, but the complex pathogenesis in detail remains unclear. In regard to the heterogeneous course, classical immunosuppressive and specific therapeutic regimens adapted to the loss of renal function will here be discussed in addition to the essential common renal supportive therapy. Renal supportive therapy alleviates secondary, surrogate effects or sequelae on renal function and proteinuria of high intraglomerular pressure and subsequent nephrosclerosis by inhibition of the renin angiotensin system (RAASB)...
November 2016: Clinical and Experimental Immunology
https://www.readbyqxmd.com/read/27234721/abdominal-aortic-calcification-in-living-kidney-donors
#13
Y E Yoon, W K Han, H H Lee, M-Y Chang, K H Huh, D C Jung, Y S Kim, Y T Oh
OBJECTIVE: This study assesses the association between abdominal aortic calcification (AAC) and renal function of living kidney donors and evaluate AAC as a surrogate marker for nephrosclerosis. METHODS: Between January 2010 and March 2013, 287 donors who underwent living donor nephrectomy were enrolled. We analyzed computed tomography angiographies and quantified AAC scores by calculating the Agatston score for the abdominal aorta. The donors were stratified into the non-AAC group (AAC score = 0; n = 238) and the AAC group (AAC score >0; n = 49)...
April 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27234718/postoperative-compensatory-changes-and-blood-flow-parameter-of-the-preserved-kidney-in-elderly-living-related-donors-evaluated-by-doppler-ultrasonography
#14
O Konno, Y Nakamura, T Yokoyama, Y Kihara, H Iwamoto, S Kawachi
INTRODUCTION: Elderly kidney donors have recently become more common in living related kidney transplantation in Japan. Therefore, it is important to evaluate whether kidney function in elderly donors after nephrectomy is preserved over long periods of time. Doppler ultrasonography measurement is practical for donors after nephrectomy because it involves simple and noninvasive examinations. Doppler ultrasonography can detect compensatory hypertrophy and blood flow parameters, namely resistive index (RI) and pulsatility index (PI), of the preserved kidney in living donors...
April 2016: Transplantation Proceedings
https://www.readbyqxmd.com/read/27190365/curcumin-ameliorates-nephrosclerosis-via-suppression-of-histone-acetylation-independent-of-hypertension
#15
Kumiko Muta, Yoko Obata, Satoru Oka, Shinichi Abe, Kana Minami, Mineaki Kitamura, Daisuke Endo, Takehiko Koji, Tomoya Nishino
BACKGROUND: Although histone acetylation, an epigenetic modification, has been reported to be related to the progression of various diseases, its involvement in nephrosclerosis is unclear. METHODS: Dahl salt-sensitive rats were used as a model of nephrosclerosis in this study. The rats were divided into three groups: (i) normal-salt diet group, (ii) high-salt diet group (HS), and (iii) HS administered daily with curcumin, a histone acetyltransferase inhibitor (HS+C)...
October 2016: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/27169257/-epidemiology-and-clinical-significance-of-nephrosclerosis
#16
Masaaki Nakayama, Kenichi Tanaka, Koichi Asahi
No abstract text is available yet for this article.
2016: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/27169256/-benign-nephrosclerosis-and-malignant-nephrosclerosis
#17
Kentaro Kohagura, Yusuke Ohya
No abstract text is available yet for this article.
2016: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/27169255/-clinical-and-pathological-features-of-nephrosclerosis
#18
Kengo Furuichi, Takashi Wada
No abstract text is available yet for this article.
2016: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/27169254/-epidemiology-and-clinical-significance-of-nephrosclerosis
#19
Hiroshi Sato, Hitoshi Sugiyama, Hiroshi Morinaga, Hitoshi Yokoyama
No abstract text is available yet for this article.
2016: Nihon Jinzo Gakkai Shi
https://www.readbyqxmd.com/read/27160653/risk-of-renal-cell-carcinoma-among-kidney-transplant-recipients-in-the-united-states
#20
S Karami, E L Yanik, L E Moore, R M Pfeiffer, G Copeland, L Gonsalves, B Y Hernandez, C F Lynch, K Pawlish, E A Engels
Renal cell carcinoma (RCC) is a common malignancy following kidney transplantation. We describe RCC risk and examine RCC risk factors among US kidney recipients (1987-2010). The Transplant Cancer Match Study links the US transplant registry with 15 cancer registries. Standardized incidence ratios (SIRs) were used to compare RCC risk (overall and for clear cell [ccRCC] and papillary subtypes) to the general population. Associations with risk factors were assessed using Cox models. We identified 683 RCCs among 116 208 kidney recipients...
May 10, 2016: American Journal of Transplantation
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