keyword
MENU ▼
Read by QxMD icon Read
search

Transitional bladder cancer

keyword
https://www.readbyqxmd.com/read/28337271/effects-of-long-term-low-and-high-dose-sodium-arsenite-exposure-in-human-transitional-cells
#1
Jianming He, Feng Wang, Fen Luo, Xuedan Chen, Xi Liang, Wenbin Jiang, Zhizhong Huang, Jiafan Lei, Fabo Shan, Xueqing Xu
Epidemiological studies have revealed the association between increased risk of bladder cancer and chronic arsenic exposure. Here, we explored biological effects of arsenic in T24. Microarray analysis was applied to analyze mRNA in T24 following 0, 2 or 5 μM sodium arsenite (As) exposure for 72 hours. Long term (up to 140 days) low-dose (200 nM) and high-dose (1,000 nM) As decreased E-cadherin protein level through different mechanisms because the mRNA levels of E-cadherin increased following low-dose As exposure but decreased following high-dose As exposure...
2017: American Journal of Translational Research
https://www.readbyqxmd.com/read/28331343/silencing-trim59-inhibits-invasion-migration-and-epithelial-to-mesenchymal-transition-via-tgf-%C3%AE-smad2-3-signaling-pathway-in-bladder-cancer-cells
#2
Wei Chen, Kai Zhao, Chenkui Miao, Aiming Xu, Jianzhong Zhang, Jundong Zhu, Shifeng Su, Zengjun Wang
The evolutionarily conserved genes that encode the tripartite motif (TRIM) protein family are involved in various biological processes, including cellular immunity, inflammatory reaction, antiviral activity, and tumor progression. One member of this protein family, Trim59, has been reported as a novel biomarker for the occurrence and progression of multiple human carcinomas, such as lung cancer, gastric cancer, cervical cancer, and osteosarcoma. However, little is known about the relationship between Trim59 and bladder carcinogenesis...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28288548/upregulated-glutathione-transferase-omega-1-correlates-with-progression-of-urinary-bladder-carcinoma
#3
Tatjana Djukic, Tatjana Simic, Marija Pljesa-Ercegovac, Marija Matic, Sonja Suvakov, Vesna Coric, Dejan Dragicevic, Ana Savic-Radojevic
OBJECTIVES: Newly discovered glutathione transferase omega 1 (GSTO1-1) plays an important role in the glutathionylation cycle, a significant mechanism of protein function regulation. GSTO1-1 expression pattern has not been studied in transitional cell carcinoma (TCC), as yet. METHODS: A total of 56 TCC tumor and corresponding non-tumor specimens were investigated. Glutathione content and thioltransferase activity were measured spectrophotometrically. Protein-glutathione mixed disulfides were measured fluorimetrically...
March 13, 2017: Redox Report: Communications in Free Radical Research
https://www.readbyqxmd.com/read/28287737/large-scale-srm-screen-of-urothelial-bladder-cancer-candidate-biomarkers-in-urine
#4
Elodie Duriez, Christophe D Masselon, Cédric Mesmin, Magali Court, Kevin Demeure, Yves Allory, Nuria Malats, Mariette Matondo, François Radvanyi, Jérôme Garin, Bruno Domon
Urothelial bladder cancer is a condition associated with high recurrence and substantial morbidity and mortality. Non-invasive urinary tests that would detect bladder cancer and tumor recurrence are required to significantly improve patient care. Over the last decade, numerous bladder cancer candidate biomarkers have been identified in the context of extensive proteomics or transcriptomics studies. To translate these findings in clinically useful biomarkers, the systematic evaluation of these candidates remains the bottleneck...
March 13, 2017: Journal of Proteome Research
https://www.readbyqxmd.com/read/28285503/development-of-urinary-bladder-pre-neoplasia-by-schistosoma-haematobium-eggs-and-chemical-carcinogen-in-mice
#5
Bayissa Chala, Min-Ho Choi, Kyung Chul Moon, Hyung Suk Kim, Cheol Kwak, Sung-Tae Hong
Schistosoma haematobium is a biocarcinogen of human urinary bladder (UB). The present study investigated developing UB cancer mouse model by injecting S. haematobium eggs into the bladder wall and introduction of chemical carcinogens. Histopathological findings showed mild hyperplasia to epithelial vacuolar change, and high grade dysplasia. Squamous metaplasia was observed in the S. haematobium eggs+NDMA group at week 12 but not in other groups. Immunohistochemistry revealed significantly high expression of Ki-67 in urothelial epithelial cells of the S...
February 2017: Korean Journal of Parasitology
https://www.readbyqxmd.com/read/28279796/tetrahydroporphyrin-tetratosylat-thpts-a-near-infrared-photosensitizer-for-targeted-and-efficient-photodynamic-therapy-pdt-of-human-bladder-carcinoma-an-in-vitro-study
#6
Mandy Berndt-Paetz, Annett Weimann, Nadine Sieger, Stanislaw Schastak, Yasser M Riyad, Jan Griebel, Vinodh K A Arthanareeswaran, Jens-Uwe Stolzenburg, Jochen Neuhaus
BACKGROUND: Efficacy of PDT in muscle-invasive bladder cancer is hampered by low tissue penetration of most photosensitizers by short excitation wavelength. THPTS is excitable at near-infrared (760nm) allowing tissue penetration up to 15mm. We examined the cellular effects of THPTS-PDT in human bladder cancer cells. MATERIAL AND METHODS: We used four human transitional carcinoma cell lines, epithelial bladder progenitors (HBLAK) and bladder smooth muscle cells (HBSMC)...
March 6, 2017: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/28275521/transurethral-resection-versus-open-bladder-cuff-excision-in-patients-undergoing-nephroureterectomy-for-upper-urinary-tract-carcinoma-operative-and-oncological-results
#7
Charalampos Fragkoulis, Athanasios Pappas, Georgios I Papadopoulos, Georgios Stathouros, Aristodimos Fragkoulis, Konstantinos Ntoumas
OBJECTIVES: To evaluate the impact of distal ureter management on oncological results after open nephroureterectomy (ONU) comparing transurethral resection of the intramural ureter to conventional open excision, as controversy still exists about the method of choice for managing the distal ureter and bladder cuff during ONU. PATIENTS AND METHODS: We retrospectively collected data from 378 patients who underwent ONU for upper urinary tract transitional cell carcinoma (UUT-TCC) from 1988 to 2009...
March 2017: Arab Journal of Urology
https://www.readbyqxmd.com/read/28272691/the-effect-of-curcumin-on-bladder-tumor-in-rat-model
#8
Z-J Pan, N Deng, Z-H Zou, G-X Chen
OBJECTIVE: Bladder cancer is the most commonly malignant tumor in the urogenital tract, only next to prostate cancer with a higher incidence in China. Curcumin is the major component of curcuma longa and has multiple biological effects including anti-tumor. This study aimed to investigate the effect of curcumin on bladder cancer. MATERIALS AND METHODS: SPF-grade Wistar rats were used for establishing bladder cancer model through injection of N-methyl-N-nitrosourea (MNU)...
February 2017: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28259934/curcumin-reverses-benzidine-induced-epithelial-mesenchymal-transition-via-suppression-of-erk5-ap-1-in-sv-40-immortalized-human-urothelial-cells
#9
Zhiqi Liu, Jie Liu, Li Zhao, Hao Geng, Jiaxing Ma, Zhiqiang Zhang, Dexin Yu, Caiyun Zhong
Overexposure to benzidine has been manifested as an important cause of bladder cancer. However, the molecular mechanism of benzidine-induced malignancy is still insufficiently interpreted. Epithelial-mesenchymal transition (EMT) is a crucial pathophysiological process in embryonic development as well as initiation and development of epithelium-originated malignant tumors. The role of extracellular regulated protein kinase 5 (ERK5) in benzidine-meditated bladder cancer development has not been explored. In the present study, we explored the role of ERK5/AP-1 pathway in benzidine-induced EMT in human normal urothelial cells and the intervention effect of curcumin on bezidine-induced EMT...
February 21, 2017: International Journal of Oncology
https://www.readbyqxmd.com/read/28258492/sox10-is-over-expressed-in-bladder-cancer-and-contributes-to-the-malignant-bladder-cancer-cell-behaviors
#10
H Yin, C Qin, Y Zhao, Y Du, Z Sheng, Q Wang, Q Song, L Chen, C Liu, T Xu
PURPOSE: To detect the expression level and significance of SOX10 in human bladder cancer. METHODS: Immunohistochemical analyses were performed to assess SOX10 protein level using a bladder cancer tissue microarray (including 59 spots of cancer tissues and 46 spots of paired normal tissues) and 31 specimens and to define the relationship between SOX10 and clinicopathological bladder cancer characteristics in patients. SOX10 protein and mRNA levels in bladder cancer cell lines (T24, 5637, BIU87, EJ) and transitional cell papilloma cell line (RT4) were tested by western blotting and quantitative real-time PCR (q-PCR), respectively...
March 3, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28256480/multiple-primary-cancers-simultaneously-occurring-prostate-cancer-and-other-primary-tumors-our-experience-and-literature-search
#11
A A Popoola, O O Abiola, T Buhari, A F Ushie, H B Olanipekun, A K Arogundade
INTRODUCTION: Prostate cancer is a leading cause of death in men all over the world, and it is becoming an increasing public health burden in sub-Saharan Africa. In our practice, we identified that prostate cancer co-existed with other primary cancers even in noncontiguous regions of the body and this co-existence impacted on our management of these patients. MATERIALS AND METHODS: We retrospectively studied a 2-year period (June 2012-July 2014), the records of patients in our hospital with prostate cancer, who in addition, had other primary cancers; and studied the management and outcomes of these patients...
March 2017: Nigerian Journal of Clinical Practice
https://www.readbyqxmd.com/read/28242163/adjuvant-radiotherapy-use-by-us-radiation-oncologists-after-radical-cystectomy-for-muscle-invasive-bladder-cancer
#12
A A Solanki, B Martin, M Korpics, C Small, M M Harkenrider, T Mitin
AIMS: Historic trials suggested significant toxicity with adjuvant radiotherapy (ART) after radical cystectomy for muscle-invasive bladder cancer (MIBC). However, recent trials have found improved locoregional control and the 2016 National Comprehensive Cancer Network (NCCN) guidelines recommend ART consideration for select patients at high risk of local recurrence. ART practice patterns among US radiation oncologists are unknown and we carried out a survey to explore current trends. MATERIALS AND METHODS: We conducted a survey of US radiation oncologists regarding the management of patients with cT2-3N0M0 transitional cell MIBC...
February 24, 2017: Clinical Oncology: a Journal of the Royal College of Radiologists
https://www.readbyqxmd.com/read/28240746/epithelial-mesenchymal-transition-promotes-sox2-and-nanog-expression-in-bladder-cancer
#13
Toshiro Migita, Ayano Ueda, Tomokazu Ohishi, Megumi Hatano, Hiroyuki Seimiya, Shin-Ichiro Horiguchi, Fumitaka Koga, Futoshi Shibasaki
Bladder cancer is the most common malignant tumor of the urothelium and is classified into non-muscle-invasive bladder cancer (NMIBC) and muscle-invasive bladder cancer (MIBC). Stemness markers such as SOX2 and NANOG are frequently overexpressed in various aggressive cancers, including MIBC; epithelial-mesenchymal transition (EMT) has been proposed as a potential trigger of stemness in cancers. To determine whether cancer stemness is acquired via EMT in bladder cancer, we studied the effect of EMT on the expression of SOX2 and NANOG in bladder cancer cell lines...
February 27, 2017: Laboratory Investigation; a Journal of Technical Methods and Pathology
https://www.readbyqxmd.com/read/28223825/usp21-promotes-cell-proliferation-and-metastasis-through-suppressing-ezh2-ubiquitination-in-bladder-carcinoma
#14
Yong Chen, Bo Zhou, Daihui Chen
Bladder cancer (BC) is the second most common malignant tumor of the urinary tract in the world. In this study, we found that ubiquitin-specific protease (USP21) was upregulated in BC and the ectopic expression of USP21 was closely associated with tumor size and metastasis. Moreover, patients with higher levels of USP21 had poorer survival rate. Multiple function analysis such as CCK-8, colony formation, wound healing, and transwell analysis indicated that USP21 regulated cell proliferation and metastasis in bladder carcinoma cell lines...
2017: OncoTargets and Therapy
https://www.readbyqxmd.com/read/28219587/management-of-bladder-cancer-after-renal-transplantation
#15
C Demirdag, S Citgez, Z Talat, B Onal
OBJECTIVES: In renal transplant recipients, the risk of developing bladder cancer and rate of diagnosis of advanced staged bladder cancer are generally higher than the general population. Also, it is more challenging to treat renal transplant recipients than the regular patient population. We aimed to evaluate the efficacy and safety of radical cystectomy (RC) and urinary diversion with ileal conduit in renal transplant recipients. METHODS: We identified 2 patients with prior history of renal transplantation who underwent RC and ileal conduit urinary diversion for bladder cancer...
March 2017: Transplantation Proceedings
https://www.readbyqxmd.com/read/28218662/microrna-expression-profile-identifies-high-grade-non-muscle-invasive-bladder-tumors-at-elevated-risk-to-progress-to-an-invasive-phenotype
#16
Sara M Lenherr, Sheaumei Tsai, Brasil Silva Neto, Travis B Sullivan, Cara B Cimmino, Tanya Logvinenko, Jason Gee, Wei Huang, John A Libertino, Ian C Summerhayes, Kimberly M Rieger-Christ
The objective of this study was to identify a panel of microRNAs (miRNAs) differentially expressed in high-grade non-muscle invasive (NMI; TaG3-T1G3) urothelial carcinoma that progress to muscle-invasive disease compared to those that remain non-muscle invasive, whether recurrence happens or not. Eighty-nine high-grade NMI urothelial carcinoma lesions were identified and total RNA was extracted from paraffin-embedded tissue. Patients were categorized as either having a non-muscle invasive lesion with no evidence of progression over a 3-year period or as having a similar lesion showing progression to muscle invasion over the same period...
February 17, 2017: Genes
https://www.readbyqxmd.com/read/28182001/rasal2-a-ras-gtpase-activating-protein-inhibits-stemness-and-epithelial-mesenchymal-transition-via-mapk-sox2-pathway-in-bladder-cancer
#17
Ke Hui, Yang Gao, Jun Huang, Shan Xu, Bin Wang, Jin Zeng, Jinhai Fan, Xinyang Wang, Yangyang Yue, Shiqi Wu, Jer-Tsong Hsieh, Dalin He, Kaijie Wu
Muscle-invasive or metastatic bladder cancer (BCa) is associated with a very poor prognosis, and the underlying mechanism remains poorly understood. In this study, we demonstrate RASAL2, a RAS GTPase-activating protein (RAS GAP), acts as a tumor suppressor in BCa. First, RASAL2 was downregulated in BCa specimens and inversely correlated with pathological grades and clinical stages. Furthermore, we observed that RASAL2 could inhibit BCa stemness and epithelial-mesenchymal transition (EMT) based on our gain-of-function and loss-of-function experiments...
February 9, 2017: Cell Death & Disease
https://www.readbyqxmd.com/read/28166762/clasp2-is-involved-in-the-emt-and-early-progression-after-transurethral-resection-of-the-bladder-tumor
#18
Bisong Zhu, Lin Qi, Sulai Liu, Wentao Liu, Zhenyu Ou, Minfeng Chen, Longfei Liu, Xiongbing Zu, Jun Wang, Yuan Li
BACKGROUND: Cytoplasmic linker-associated protein 2 (CLASP2) belongs to a family of microtubule plus-end tracking proteins that localizes to the distal ends of microtubules and regulate microtubule dynamics. We speculated that it might be involved in the epithelial-mesenchymal transition (EMT) and progression of bladder cancer (BC). METHODS: Western blotting and RT-PCR were used to detect the changes at protein and mRNA levels in BC cell lines. Cell proliferation, clonogenic formation, wound healing and chamber invasion assay were used to investigate the abilities of cellular proliferation, migration and invasion...
February 6, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28138411/granulomatous-prostatitis-after-intravesical-immunotherapy-mimicking-prostate-cancer
#19
Waldemar Białek, Sławomir Rudzki, Paweł Iberszer, Lech Wronecki
Intravesical immunotherapy with attenuated strains of Mycobacterium bovis is a widely used therapeutic option in patients with non-muscle-invasive transitional cell carcinoma of the bladder. A rare complication of intravesical therapy with the Bacillus Calmette-Guérin vaccine is granulomatous prostatitis, which due to increasing levels of prostate-specific antigen and abnormalities found in transrectal examination of the prostate may suggest concomitant prostate cancer. A case of extensive granulomatous prostatitis in a 61-year-old patient which occurred after the first course of a well-tolerated Bacillus Calmette-Guérin therapy is presented...
December 2016: Journal of Ultrasonography
https://www.readbyqxmd.com/read/28128913/overexpression-of-uhrf1-gene-correlates-with-the-major-clinicopathological-parameters-in-urinary-bladder-cancer
#20
Skender Saidi, Zivko Popov, Vesna Janevska, Sasho Panov
INTRODUCTION: Recently, expression of the UHRF1 gene was found to be up-regulated in numerous neoplasms, including the urinary bladder transitional cell carcinoma (TCC). OBJECTIVE: The aim of our study was to determine if the expression levels of UHRF1 gene correlates with the major pathological characteristics of the tumor and patients' clinical outcome. MATERIALS AND METHODS: In our study, we have analyzed the tissue samples derived from group of 70 patients with histologically confirmed TCC of the urinary bladder, while normal urinary bladder mucosa obtained from 40 patients with nonmalignant diseases was used as a negative control group...
March 2017: International Braz J Urol: Official Journal of the Brazilian Society of Urology
keyword
keyword
92895
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"