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Functional gastrointestinal disorders

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https://www.readbyqxmd.com/read/29333891/therapeutic-potential-of-zataria-multiflora-boiss-in-treatment-of-irritable-bowel-syndrome-ibs
#1
Mohaddese Mahboubi
Irritable Bowel syndrome (IBS), the most common chronic functional gastrointestinal disorder, is categorized as IBS-C and IBS-D, which are equivalent to Ghoolenj Rihi and Maghs Rihi in Iranian traditional medicine. One of the main applications of Zataria multiflora Boiss in traditional medicine is its efficacy in the gastrointestinal tract with symptoms such as IBS. The aim of this study was to evaluate the efficacy of Zataria multiflora essential oil in management of IBS. We used all the accessible references (electronic and published books, theses, and reports) to write this article...
January 15, 2018: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/29333061/critical-appraisal-of-rome-iv-criteria-hypersensitive-esophagus-does-belong-to-gastroesophageal-reflux-disease-spectrum
#2
REVIEW
Leonardo Frazzoni, Marzio Frazzoni, Nicola de Bortoli, Salvatore Tolone, Irene Martinucci, Lorenzo Fuccio, Vincenzo Savarino, Edoardo Savarino
The Rome IV Committee introduced a major change in the classification of functional gastrointestinal disorders, proposing a more restrictive definition of gastroesophageal reflux disease (GERD). It was suggested that hypersensitive esophagus (HE) may sit more firmly within the functional realm. It was suggested that GERD diagnosis should be based upon abnormal acid exposure time (AET) only, implying no advantage of impedance-pH over pH monitoring. Symptom association probability (SAP), symptom index (SI) and heartburn relief with proton pump inhibitor (PPI) therapy were regarded as unreliable, whereas a lack of response to PPI was considered as evidence of functional heartburn...
January 2018: Annals of Gastroenterology: Quarterly Publication of the Hellenic Society of Gastroenterology
https://www.readbyqxmd.com/read/29332637/pilot-rct-of-an-integrative-group-therapy-for-patients-with-refractory-irritable-bowel-syndrome-isrctn02977330
#3
S Berens, E Stroe-Kunold, F Kraus, J Tesarz, A Gauss, B Niesler, W Herzog, R Schaefert
OBJECTIVE: Different forms of psychotherapeutic treatments have been proven effective in irritable bowel syndrome (IBS), but disorder-oriented and integrative concepts are still rare. Therefore, we implemented and evaluated an integrative group therapeutic concept within an interdisciplinary tertiary care clinic for functional gastrointestinal disorders (FGIDs). AIMS: present our integrative group concept, assess feasibility issues, and evaluate efficacy. METHODS: A pilot-RCT with a randomized controlled wait-listed group design was conducted...
February 2018: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/29327358/opioid-medication-use-in-patients-with-gastrointestinal-diagnoses-vs-unexplained-gastrointestinal-symptoms-in-the-us-veterans-health-administration
#4
G S Sayuk, N Kanuri, C P Gyawali, B M Gott, B D Nix, R A Rosenheck
BACKGROUND: While opioid prescriptions have increased alarmingly in the United States (US), their use for unexplained chronic gastrointestinal (GI) pain (eg, irritable bowel syndrome) carries an especially high risk for adverse effects and questionable benefit. AIM: To compare opioid use among US veterans with structural GI diagnoses (SGID) and those with unexplained GI symptoms or functional GI diagnoses (FGID), a group for whom opioids have no accepted role. METHODS: Veterans Health Administration (VHA) administrative data from fiscal year 2012 were used to identify veterans with diagnostic codes recorded for SGID and FGID...
January 12, 2018: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/29318638/voltage-gated-sodium-channels-nav-igating-the-field-to-determine-their-contribution-to-visceral-nociception
#5
Andelain Erickson, Annemie Deiteren, Andrea M Harrington, Sonia Garcia-Caraballo, Joel Castro, Ashlee Caldwell, Luke Grundy, Stuart M Brierley
Chronic visceral pain, altered motility and bladder dysfunction are common, yet poorly managed symptoms of functional and inflammatory disorders of the gastrointestinal and urinary tracts. Recently, numerous human channelopathies of the voltage-gated sodium (NaV ) channel family have been identified, which induce either painful neuropathies, an insensitivity to pain, or alterations in smooth muscle function. The identification of these disorders, in addition to the recent utilisation of genetically modified NaV mice and specific NaV channel modulators, has shed new light on how NaV channels contribute to the function of neuronal and non-neuronal tissues within the gastrointestinal tract and bladder...
January 9, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29316591/minimally-invasive-myotomy-percutaneous-laparoscopic-surgical-approach-for-achalasia
#6
Lavinia Alessandra Barbieri, Davide Bona, Alberto Aiolfi, Giancarlo Micheletto, Marta Cavalli, Francesca Lombardo, Piero Giovanni Bruni, Giampiero Campanelli
The laparoscopic approach of the upper gastrointestinal tract is considered the gold standard for the treatment of functional benign esophageal disorders since 1990. In recent years, many efforts have been made to minimize the abdominal wall's trauma to reduce postoperative pain and to obtain a prompt return to daily activities, as well as improve cosmetic results of surgery. The progressive development of novel surgical devices has allowed for the introduction of new minimally-invasive surgical techniques...
December 22, 2017: Surgical Technology International
https://www.readbyqxmd.com/read/29316246/sleep-quality-and-functional-gastrointestinal-disorders-a-psychological-issue
#7
Michel Bouchoucha, Florence Mary, Cyriaque Bon, Bakhtiar Bejou, Gheorghe Airinei, Robert Benamouzig
BACKGROUND / AIMS: Sleep disorders are often associated with functional gastro-intestinal disorders (FGIDs). This study aims to evaluate the association of sleep disorders with specific FGIDs and to assess the related importance of psychological disorders. METHODS: We included 1009 consecutive FGID patients (71% female), aged 48.2 ± 16.7 years (M±SD), BMI 26.9 ± 11.2 kg/m2 . These patients filled in a Rome III questionnaire and underwent a psychological evaluation on anxiety and depression...
January 8, 2018: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/29314441/alterations-in-the-gut-barrier-and-involvement-of-toll-like-receptor-4-in-murine-postoperative-ileus
#8
S-S Lin, R-Q Zhang, L Shen, X-J Xu, K Li, A-V Bazhin, J Fichna, Y-Y Li
BACKGROUND: The changes in the gut barrier (GB) and associated mechanisms in postoperative ileus (POI) are still unclear. Toll-like receptor 4 (TLR4) is involved in inflammation, which may cause GB dysfunction and POI. Here, the roles of the GB in POI in relation to TLR4-dependent signaling pathways were explored. METHODS: POI was induced by small bowel manipulation in wild-type (WT) and TLR4-knockout (TLR4-/-) mice. Twenty-four hours after manipulation, indices of gastrointestinal (GI) transit, GB structure and function, inflammation, and related signaling pathways were analyzed...
January 4, 2018: Neurogastroenterology and Motility: the Official Journal of the European Gastrointestinal Motility Society
https://www.readbyqxmd.com/read/29305648/multicenter-observational-study-on-functional-bowel-disorders-diagnosed-using-rome-iii-diagnostic-criteria-in-japan
#9
Masayoshi Ono, Mototsugu Kato, Shuichi Miyamoto, Momoko Tsuda, Takeshi Mizushima, Shouko Ono, Manabu Nakagawa, Katsuhiro Mabe, Soichi Nakagawa, Shuichi Muto, Yuichi Shimizu, Mineo Kudo, Shinichi Katsuki, Takashi Meguro, Naoya Sakamoto
BACKGROUND: The Rome III diagnostic criteria had been used to diagnose functional gastrointestinal disorders (FGIDs) world wide, and functional bowel disorders (FBDs) including irritable bowel syndrome (IBS) have recently attracted the attention of Japanese physicians. However, there have been few reports on the prevalence of FBDs diagnosed by the Rome III diagnostic criteria. AIMS: The aim of this study was to determine the prevalence of FBDs diagnosed according to the diagnostic criteria of Rome III in Japan...
January 5, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29305172/gastrointestinal-factors-regulating-lipid-droplet-formation-in-the-intestine
#10
REVIEW
N Auclair, L Melbouci, D St-Pierre, E Levy
Cytoplasmic lipid droplets (CLD) are considered as neutral lipid reservoirs, which protect cells from lipotoxicity. It became clear that these fascinating dynamic organelles play a role not only in energy storage and metabolism, but also in cellular lipid and protein handling, inter-organelle communication, and signaling among diverse functions. Their dysregulation is associated with multiple disorders, including obesity, liver steatosis and cardiovascular diseases. The central aim of this review is to highlight the link between intra-enterocyte CLD dynamics and the formation of chylomicrons, the main intestinal dietary lipid vehicle, after overviewing the morphology, molecular composition, biogenesis and functions of CLD...
January 2, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29300762/drug-repurposing-in-vitro-anti-glycation-properties-of-18-common-drugs
#11
Saima Rasheed, Sara S Sánchez, Sammer Yousuf, Stella M Honoré, M Iqbal Choudhary
Drug repositioning or repurposing, i.e. identifying new indications for existing drugs, has gained increasing attention in the recent years. This approach enables the scientists to discover "new targets" for known drugs in a cost and time efficient manner. Glycation, the non-enzymatic reaction of sugars with proteins or nucleic acids to form early glycation (Amadori or fructosamine) products, is a key molecular basis of diabetic complications. Inhibiting the process of non-enzymatic protein glycation is one of the key strategies to prevent glycation-mediated diabetic complications...
2018: PloS One
https://www.readbyqxmd.com/read/29287016/seasonal-association-of-pediatric-functional-abdominal-pain-disorders-and-anxiety
#12
Katharine L Pollard, Christina Campbell, Megan Squires, Olafur Palsson, Miranda A L van Tilburg
OBJECTIVES: Abdominal pain related pediatric functional gastrointestinal disorders (AP-FGID) are defined by abdominal discomfort or pain that may provide obstacles to everyday activities, such as school attendance. It has been reported that AP-FGID symptoms may be reduced in summer, but it is unclear what drives this seasonal variation. This pilot study aimed to explore whether the seasonal variation in AP-FGID symptoms could be explained by various psychological and behavioral factors...
December 28, 2017: Journal of Pediatric Gastroenterology and Nutrition
https://www.readbyqxmd.com/read/29285159/amelioration-of-the-dss-induced-colitis-in-mice-by-pretreatment-with-4-4-diaponeurosporene-producing-bacillus-subtilis
#13
Yuchao Jing, Haofei Liu, Wenwen Xu, Qian Yang
Inflammatory bowel disease (IBD) is a chronically relapsing inflammatory disorder of the gastrointestinal tract. Current IBD treatments have poor tolerability and insufficient therapeutic efficacy, thus, alternative therapeutic approaches are required. Recently, a number of dietary supplements have emerged as promising interventions. In the present study oral administration of a carotenoid (4,4'-diaponeurosporene)-producing Bacillus subtilis markedly ameliorated dextran sulfate sodium salt-induced mouse colitis, as demonstrated by a reduction in weight loss and the severity of bleeding, which indicated that 4,4'-diaponeurosporene may have beneficial effects on treatments for colitis...
December 2017: Experimental and Therapeutic Medicine
https://www.readbyqxmd.com/read/29281686/personal-relative-deprivation-associated-with-functional-disorders-via-stress-an-examination-of-fibromyalgia-and-gastrointestinal-symptoms
#14
Shadi Beshai, Sanju Mishra, Sandeep Mishra, R Nicholas Carleton
BACKGROUND: Personal relative deprivation is a negative social comparison process typified by self-comparison, negative appraisal, and resultant negative emotionality. Personal relative deprivation has been associated with poorer physical and mental health in several domains. It has been hypothesized that the deprivation-health link operates through a stress pathway. Stress has been specifically implicated in the onset and maintenance of functional disorders, including fibromyalgia and functional gastrointestinal disorders...
2017: PloS One
https://www.readbyqxmd.com/read/29280689/irritable-bowel-syndrome-and-quality-of-life-in-a-community-dwelling-population-in-japan
#15
Norio Sugawara, Ken Sato, Ippei Takahashi, Ryu Satake, Shinsaku Fukuda, Shigeyuki Nakaji, Norio Yasui-Furukori
Objective Irritable bowel syndrome (IBS) is one of the most common gastrointestinal disorders and is characterized by recurrent abdominal pain or abnormal defecation. This investigation evaluated the relationship between IBS and self-reported quality of life in a community-dwelling population in Japan. Methods For this cross-sectional survey, we enrolled 1002 volunteers who participated in the Iwaki Health Promotion Project in 2013. IBS symptoms were evaluated using the criteria from the Japanese version of the Rome III Questionnaire...
January 1, 2017: International Journal of Psychiatry in Medicine
https://www.readbyqxmd.com/read/29280668/-the-dynamic-gastrointestinal-simulator-simgi%C3%A2-a-useful-tool-for-clinical-nutrition
#16
Alba Tamargo García, Irene Gil Sánchez, Beatriz Miralles, Diana Martín, Mónica Rodríguez García-Risco, Tiziana Fornari, Begoña Bartolomé, Mª Victoria Moreno-Arribas, Carolina Cueva
The human gastrointestinal tract harbours the most complex and abundant community of the human body, the colon being where the highest microbial concentration is found (1012 cell/g). The intestinal microbiota exerts metabolic, trophic and protective functions which are important in the maintenance of the host health. Over recent decades, numerous studies have attempted to provide scientific evidence about the environmental factors that can impact on human health through the modulation of the intestinal microbiota composition...
November 17, 2017: Nutrición Hospitalaria: Organo Oficial de la Sociedad Española de Nutrición Parenteral y Enteral
https://www.readbyqxmd.com/read/29279597/severe-asymptomatic-hypophosphataemia-in-a-child-with-t-acute-lymphoblastic-leukaemia
#17
N H Zakaria, P Sthaneshwar, H Shanmugam
Hypophosphataemia is a metabolic disorder that is commonly encountered in critically ill patients. Phosphate has many roles in physiological functions, thus the depletion of serum phosphate could lead to impairment in multiple organ systems, which include the respiratory, cardiovascular, neurological and muscular systems and haematological and metabolic functions. Hypophosphataemia is defined as plasma phosphate level below 0.80 mmol per litre (mmol/L) and can be further divided into subgroups of mild (plasma phosphate of 0...
December 2017: Malaysian Journal of Pathology
https://www.readbyqxmd.com/read/29278684/isolation-of-human-lymphocytes-with-high-yield-and-viability-from-the-gastrointestinal-and-female-reproductive-tract-of-a-humanized-drag-mouse
#18
Atef Allam, Kristina K Peachman, Rodrigo Aguilera-Olvera, Sofia Casares, Mangala Rao
The mucosal tissues of the gut and female reproductive tract (FRT) are susceptible to pathogen infections including bacteria, viruses, and parasites, and are also the targets for immune disorders such as Crohn's disease, inflammatory bowel disease (IBD), and many types of cancers. However, the role of the mucosal immune cells to control these diseases is largely unknown. The limited availability of human mucosal biopsy tissue and the low number of cells that can be isolated from these tissues hampers the characterization of the phenotype and function of human mucosal immune cell subsets...
December 23, 2017: Journal of Immunological Methods
https://www.readbyqxmd.com/read/29274869/neuromodulators-for-functional-gi-disorders-disorders-of-gut-brain-interaction-a-rome-foundation-working-team-report
#19
REVIEW
Douglas A Drossman, Jan Tack, Alexander C Ford, Eva Szigethy, Hans Törnblom, Lukas Van Oudenhove
BACKGROUND AND AIMS: Central neuromodulators (antidepressants, antipsychotics and other CNS targeted medications) are increasingly used for treatment of functional GI disorders (FGIDs), now recognized as disorders of gut-brain interaction. However, the available evidence and guidance for the use of central neuromodulators in these conditions is scanty and incomplete. In this Rome Foundation Working Team report, a multidisciplinary team summarized available research evidence and clinical experience to provide guidance and treatment recommendations...
December 21, 2017: Gastroenterology
https://www.readbyqxmd.com/read/29274173/investigation-of-autophagy-and-differentiation-of-myenteric-interstitial-cells-of-cajal-in-the-pathogenesis-of-gastric-motility-disorders-in-rats-with-functional-dyspepsia
#20
Li-Min Zhang, Li-Jun Zeng, Jing Deng, Yu-Qin Zhang, Yu-Jiao Wang, Tian-Yi Xie, Jiang-Hong Ling
BACKGROUND: Interstitial cells of Cajal (ICC), especially myenteric interstitial cells of Cajal (ICC-MY), are key to gastrointestinal motility. However, their role in the pathogenesis of functional dyspepsia (FD) is unclear. Therefore, autophagy and differentiation of ICC-MY were investigated to elucidate the pathogenesis of gastric motility disorder in FD. METHODS: FD model was induced by chronic stress via tail clamping in rats, which was assessed by the vital signs of rats, gastric emptying rate result and histology...
December 23, 2017: Biotechnology and Applied Biochemistry
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