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https://www.readbyqxmd.com/read/27898642/manipulation-of-muscle-creatine-and-glycogen-changes-dxa-estimates-of-body-composition
#1
Julia L Bone, Megan L Ross, Kristyen A Tomcik, Nikki A Jeacocke, Will G Hopkins, Louise M Burke
: Standardising a dual x-ray absorptiometry (DXA) protocol is thought to provide a reliable measurement of body composition. PURPOSE: We investigated the effects of manipulating muscle glycogen and creatine content independently and additively on DXA estimates of lean mass. METHOD: Eighteen well-trained male cyclists undertook a parallel group application of creatine loading (n=9) (20 g/d for 5 d loading; 3 g/d maintenance) or placebo (n=9) with crossover application of glycogen loading (12 v 6 g/kg BM/d for 48 h) as part of a larger study involving a glycogen-depleting exercise protocol...
November 28, 2016: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/27813551/rehmannia-glutinosa-oligosaccharide-induces-differentiation-of-bone-marrow-mesenchymal-stem-cells-into-cardiomyocyte-like-cells
#2
X H Wang, H W Du, X H Guo, S W Wang, R B Zhou, Y Li, Z B Li, Y S Zhao, Q L Zhu
The aim of this study was to observe the effect of Rehmannia glutinosa oligosaccharide (RGO) on differentiation of bone marrow mesenchymal stem cells (MSCs) into cardiomyocyte-like cells . Rat MSCs were isolated, treated, and grouped as follows: RGO treatment group, 5-azacytidine (5-aza) treatment group, RGO + 5-aza treatment group, and control group. Following a four-week induction period, cardiac troponin I (cTnI) levels in MSCs were quantified by chemiluminescence, and the levels of myocardial enzymes creatine kinase (CK) and creatine kinase isoenzyme-MB (CK-MB) were measured using a dry chemistry analyzer...
October 17, 2016: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/27747899/safety-and-efficacy-of-outpatient-parenteral-antibiotic-therapy-in-an-academic-infectious-disease-clinic
#3
G Suleyman, R Kenney, M J Zervos, A Weinmann
WHAT IS KNOWN AND OBJECTIVE: Outpatient parenteral therapy (OPAT) has become a safe and effective modality for patients requiring intravenous or prolonged antimicrobial therapy since the 1970s. It is being increasingly utilized in various settings; however, studies evaluating the safety and efficacy of clinic-based OPAT are limited. Since 2012, patients being considered for OPAT have required an infectious disease (ID) consultation at our institution. Candidates receiving once-daily antimicrobials who were ineligible for home infusion or nursing home placement as determined by their insurance companies and those who preferred the clinic over nursing home or home infusion were referred to the ID clinic...
October 16, 2016: Journal of Clinical Pharmacy and Therapeutics
https://www.readbyqxmd.com/read/27722178/acute-lymphoblastic-leukemia-in-a-young-adult-presenting-as-hepatitis-and-acute-kidney-injury
#4
Marc Heincelman, Nithin Karakala, Don C Rockey
Acute lymphoblastic leukemia (ALL) in adults is a relatively rare malignancy. The typical presentation includes signs and symptoms associated with bone marrow failure, including fevers, infections, fatigue, and excessive bruising. In this article, we report an unusual systemic presentation of ALL in a previously healthy 18-year-old man. He initially presented with several-day history of nausea and vomiting, 10-pound weight loss, and right upper quadrant abdominal pain with evidence of acute hepatocellular liver injury (elevations in aspartate aminotransferase/alanine aminotransferase) and elevation in serum creatinine...
July 2016: Journal of Investigative Medicine High Impact Case Reports
https://www.readbyqxmd.com/read/27661794/rivaroxaban-significantly-inhibits-the-stimulatory-effects-of-bone-modulating-hormones-in-vitro-study-of-primary-female-osteoblasts
#5
Dalia Somjen, Zachary T Sharfman, Sara Katzburg, Orli Sharon, Eran Maman, Moshe Salai, Naftali Stern, Oleg Dolkart
BACKGROUND: Anticoagulant therapy is a mainstay of treatment subsequent to major orthopedic surgeries. Evidence linking anticoagulant therapy, osteoporosis, and delayed fracture healing is not conclusive. We have previously reported that rivaroxaban significantly inhibited cell growth and energy metabolism in a human osteoblastic cell line. This study analyzed the response of primary female osteoblast cells to rivaroxaban in combination with various bone-modulating hormones. METHODS: Bone samples were taken from both premenopausal (pre-Ob) and postmenopausal (post-Ob) women...
August 11, 2016: Connective Tissue Research
https://www.readbyqxmd.com/read/27562566/serum-creatine-kinase-isoenzymes-in-children-with-osteogenesis-imperfecta
#6
P D'Eufemia, R Finocchiaro, A Zambrano, V Lodato, L Celli, S Finocchiaro, P Persiani, A Turchetti, M Celli
: This study evaluates serum creatine kinase isoenzyme activity in children with osteogenesis imperfecta to determine its usefulness as a biochemical marker during treatment with bisphosphonate. The changes of creatine kinase (CK) isoenzyme activity during and after discontinuation therapy were observed. These results could be useful in addressing over-treatment risk prevention. INTRODUCTION: The brain isoenzyme of creatine kinase (CKbb) is highly expressed in mature osteoclasts during osteoclastogenesis, thus plays an important role in bone resorption...
August 25, 2016: Osteoporosis International
https://www.readbyqxmd.com/read/27453229/oculopharyngeal-weakness-hypophrenia-deafness-and-impaired-vision-a-novel-autosomal-dominant-myopathy-with-rimmed-vacuoles
#7
Ting Chen, Xiang-Hui Lu, Hui-Fang Wang, Rui Ban, Hua-Xu Liu, Qiang Shi, Qian Wang, Xi Yin, Chuan-Qiang Pu
BACKGROUND: Myopathies with rimmed vacuoles are a heterogeneous group of muscle disorders with progressive muscle weakness and varied clinical manifestations but similar features in muscle biopsies. Here, we describe a novel autosomal dominant myopathy with rimmed vacuoles in a large family with 11 patients of three generations affected. METHODS: A clinical study including family history, obstetric, pediatric, and development history was recorded. Clinical examinations including physical examination, electromyography (EMG), serum creatine kinase (CK), bone X-rays, and brain magnetic resonance imaging (MRI) were performed in this family...
August 5, 2016: Chinese Medical Journal
https://www.readbyqxmd.com/read/27442680/rhabdomyolysis-associated-with-single-dose-intravenous-esomeprazole-administration-a-case-report
#8
Dae-Hong Jeon, Yire Kim, Min Jeong Kim, Hyun Seop Cho, Eun Jin Bae, Se-Ho Chang, Dong Jun Park
BACKGROUND: Proton pump inhibitors are usually safe, although serious adverse effects can occur. We report the first case of rhabdomyolysis associated with single-dose intravenous esomeprozole administration. METHODS: A 45-year-old Korean male visited our emergency room because of persistent lower chest discomfort that started 10 hours before. He had been diagnosed with diabetes and coronary heart disease, but discontinued oral hypoglycemic agents 1 month earlier...
July 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27373502/prophylactic-pamidronate-partially-protects-from-glucocorticoid-induced-bone-loss-in-the-mdx-mouse-model-of-duchenne-muscular-dystrophy
#9
Sung-Hee Yoon, Jinghan Chen, Marc D Grynpas, Jane Mitchell
Glucocorticoids are extensively used to treat patients with Duchenne muscular dystrophy because of their ability to delay muscle damage, prolong ambulation and extend life. However, use of glucocorticoids significantly increases bone loss, fragility and fractures. To determine if antiresorptive bisphosphonates could prevent the effects of glucocorticoids on bone quality, we used dystrophic mdx mice treated with the glucocorticoid prednisone during 8weeks of rapid bone growth from 5 to 13weeks of age and treated some mice with the bisphosphonate pamidronate during the first two weeks of prednisone administration...
September 2016: Bone
https://www.readbyqxmd.com/read/27267921/musculoskeletal-pain-in-patients-with-chronic-kidney-disease
#10
Francisco Caravaca, Boris Gonzales, Miguel Ángel Bayo, Enrique Luna
INTRODUCTION: Chronic musculoskeletal pain (CMP) is a very common symptom in patients with chronic kidney disease (CKD), and is associated with a significant deterioration in quality of life. AIMS: To determine the prevalence and clinical characteristics associated with CMP in patients with advanced CKD not on dialysis, and to analyse their relation with other uraemic symptoms and their prognosis significance. MATERIAL AND METHODS: Cross-sectional study to analyse the uraemic symptoms of an unselected cohort of patients with CKD stage 4-5 pre-dialysis...
July 2016: Nefrología: Publicación Oficial de la Sociedad Española Nefrologia
https://www.readbyqxmd.com/read/27239423/impact-of-creatine-supplementation-in-combination-with-resistance-training-on-lean-mass-in-the-elderly
#11
Camila Lemos Pinto, Patrícia Borges Botelho, Juliana Alves Carneiro, João Felipe Mota
BACKGROUND: Human ageing is a process characterized by loss of muscle mass, strength, and bone mass. We aimed to examine the efficacy of low-dose creatine supplementation associated with resistance training on lean mass, strength, and bone mass in the elderly. METHODS: This was a 12-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups: placebo plus resistance training (PL + RT) and creatine supplementation plus resistance training (CR + RT) ...
September 2016: Journal of Cachexia, Sarcopenia and Muscle
https://www.readbyqxmd.com/read/27173751/spinal-cord-infusion-of-stem-cells-in-amyotrophic-lateral-sclerosis-magnetic-resonance-spectroscopy-shows-metabolite-improvement-in-the-precentral-gyrus
#12
José M García Santos, Alberto Inuggi, Joaquín Gómez Espuch, Carlos Vázquez, Francisca Iniesta, Miguel Blanquer, José María Moraleda, Salvador Martínez
BACKGROUND AIMS: We aimed to investigate whether magnetic resonance spectroscopy (MRS) metabolite ratios change in the precentral gyrus of patients with amyotrophic lateral sclerosis (ALS) after spinal cord surgical injection of bone marrow mononuclear cells, as well as their relationship with disability and survival. METHODS: Stem cells were surgically injected in the spinal cord of 11 spinal-onset amyotrophic lateral sclerosis patients (group 1); 21 matched patients were the control group (group 2), comprising ALS patients with an intrathecal saline infusion...
June 2016: Cytotherapy
https://www.readbyqxmd.com/read/27109613/glucocorticoid-steroid-and-alendronate-treatment-alleviates-dystrophic-phenotype-with-enhanced-functional-glycosylation-of-%C3%AE-dystroglycan-in-mouse-model-of-limb-girdle-muscular-dystrophy-with-fkrpp448l-mutation
#13
Bo Wu, Sapana N Shah, Peijuan Lu, Stephanie M Richardson, Lauren E Bollinger, Anthony Blaeser, Kyle L Madden, Yubo Sun, Taylor M Luckie, Michael D Cox, Susan Sparks, Amy D Harper, Qi Long Lu
Fukutin-related protein-muscular dystrophy is characterized by defects in glycosylation of α-dystroglycan with variable clinical phenotypes, most commonly as limb-girdle muscular dystrophy 2I. There is no effective therapy available. Glucocorticoid steroids have become the standard treatment for Duchenne and other muscular dystrophies with serious adverse effects, including excessive weight gain, immune suppression, and bone loss. Bisphosphonates have been used to treat Duchenne muscular dystrophy for prevention of osteoporosis...
June 2016: American Journal of Pathology
https://www.readbyqxmd.com/read/27108136/creatine-supplementation-in-the-aging-population-effects-on-skeletal-muscle-bone-and-brain
#14
REVIEW
Bruno Gualano, Eric S Rawson, Darren G Candow, Philip D Chilibeck
This narrative review aims to summarize the recent findings on the adjuvant application of creatine supplementation in the management of age-related deficits in skeletal muscle, bone and brain metabolism in older individuals. Most studies suggest that creatine supplementation can improve lean mass and muscle function in older populations. Importantly, creatine in conjunction with resistance training can result in greater adaptations in skeletal muscle than training alone. The beneficial effect of creatine upon lean mass and muscle function appears to be applicable to older individuals regardless of sex, fitness or health status, although studies with very old (>90 years old) and severely frail individuals remain scarce...
August 2016: Amino Acids
https://www.readbyqxmd.com/read/26946771/acute-myocardial-infarction-during-induction-chemotherapy-for-acute-mll-t-4-11-leukemia-with-lineage-switch-and-extreme-leukocytosis
#15
Natasa Colović, Andrija Bogdanović, Marijana Virijević, Ana Vidović, Dragica Tomin
INTRODUCTION: In patients with acute leukemias hemorrhage is the most frequent problem. Vein thrombotic events may appear rarely but arterial thromboses are exceptionally rare. We present a patient with acute leukemia and bilateral deep leg vein thrombosis who developed an acute myocardial infarction (AMI) during induction chemotherapy. The etiology and treatment of AMI in patients with acute leukemia, which is a rare occurrence, is discussed. CASE OUTLINE: In April of 2012 a 37-year-old male presented with bilateral deep leg vein thrombosis and malaise...
November 2015: Srpski Arhiv za Celokupno Lekarstvo
https://www.readbyqxmd.com/read/26910814/creatine-enhances-transdifferentiation-of-bone-marrow-stromal-cell-derived-neural-stem-cell-into-gabaergic-neuron-like-cells-characterized-with-differential-gene-expression
#16
Shahram Darabi, Taki Tiraihi, AliReza Delshad, Majid Sadeghizadeh, Taher Taheri, Hayder K Hassoun
Creatine was reported to induce bone marrow stromal cells (BMSC) into GABAergic neuron-like cells (GNLC). In a previous study, creatine was used as a single inducer for BMSC into GNLC with low yield. In this study, BMSC-derived neurospheres (NS) have been used in generating GABAergic phenotype. The BMSC were isolated from adult rats and used in generating neurospheres and used for producing neural stem cells (NSC). A combination of all-trans-retinoic acid (RA), the ciliary neurotrophic factor (CNTF), and creatine was used in order to improve the yield of GNLC...
February 24, 2016: Molecular Neurobiology
https://www.readbyqxmd.com/read/26904710/treatment-of-hypophosphatasia-by-muscle-directed-expression-of-bone-targeted-alkaline-phosphatase-via-self-complementary-aav8-vector
#17
Aki Nakamura-Takahashi, Koichi Miyake, Atsushi Watanabe, Yukihiko Hirai, Osamu Iijima, Noriko Miyake, Kumi Adachi, Yuko Nitahara-Kasahara, Hideaki Kinoshita, Taku Noguchi, Shinichi Abe, Sonoko Narisawa, Jose Luis Millán, Takashi Shimada, Takashi Okada
Hypophosphatasia (HPP) is an inherited disease caused by genetic mutations in the gene encoding tissue-nonspecific alkaline phosphatase (TNALP). This results in defects in bone and tooth mineralization. We recently demonstrated that TNALP-deficient (Akp2 (-/-) ) mice, which mimic the phenotype of the severe infantile form of HPP, can be treated by intravenous injection of a recombinant adeno-associated virus (rAAV) expressing bone-targeted TNALP with deca-aspartates at the C-terminus (TNALP-D10) driven by the tissue-nonspecific CAG promoter...
2016: Molecular Therapy. Methods & Clinical Development
https://www.readbyqxmd.com/read/26830838/methicillin-resistant-staphylococcal-periprosthetic-joint-infections-can-be-effectively-controlled-by-systemic-and-local-daptomycin
#18
Feng-Chih Kuo, Shih-Hsiang Yen, Kuo-Ti Peng, Jun-Wen Wang, Mel S Lee
BACKGROUND: Methicillin-resistant Staphylococcus remains a serious problem in the treatment of periprosthetic joint infection (PJI). Higher failure rates were reported when vancomycin was used in 2-stage exchange arthroplasty. Therefore a better therapeutic drug is needed to treat PJI caused by methicillin-resistant organisms. The purpose of the study was to evaluate the safety and efficacy of daptomycin when administered in bone cement combined with systemic use for methicillin-resistant Staphylococci PJI...
February 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/26739525/l-carnitine-but-not-coenzyme-q10-enhances-the-anti-osteoporotic-effect-of-atorvastatin-in-ovariectomized-rats
#19
COMPARATIVE STUDY
Hussam A S Murad
OBJECTIVE: Statins' therapy in osteoporosis can aggravate muscle damage. This study was designed to assess which agent, L-carnitine or coenzyme Q10, could enhance the anti-osteoporotic effect of atorvastatin while antagonizing myopathy in ovariectomized rats. METHODS: Forty-eight female Sprague Dawley rats were used; forty rats were ovariectomized while eight were sham-operated. Eight weeks post-ovariectomy, rats were divided into ovariectomized-untreated group and four ovariectomized-treated groups (n=8) which received by gavage (mg/(kg∙d), for 8 weeks) 17β-estradiol (0...
January 2016: Journal of Zhejiang University. Science. B
https://www.readbyqxmd.com/read/26623286/agarose-cell-block-technique-as-a-complementary-method-in-the-diagnosis-of-fungal-osteomyelitis-in-a-dog
#20
D S Zanoni, F Grandi, D Q Cagnini, S M G Bosco, N S Rocha
A 7-year-old Labrador Retriever female dog presenting left forelimb lameness for one day was admitted to the Veterinary Hospital (UNESP-Botucatu) for clinical evaluation. Several tests, including blood and image analysis, microbiological culture and cytology of lytic areas of affected bone were made in order to establish a diagnosis. Serum biochemical profile revealed increased levels of liver enzymes, plasma globulin, creatine kinase (CK) and calcium. Hemogram revealed anemia and leukocytosis; left humerus image analysis revealed an osteolytic lesion and cytology revealed a suppurative periostitis...
2012: Open veterinary journal
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