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https://www.readbyqxmd.com/read/28321200/the-importance-of-metamemory-functioning-to-the-pathogenesis-of-psychosis
#1
REVIEW
Sarah Eisenacher, Mathias Zink
Many studies up to date have implied that biases in the metacognition of memory, so called metamemory, contribute to the development and maintenance of positive symptoms in schizophrenia. However, no study exists which has longitudinally followed patients experiencing positive symptoms. The present article therefore reviews cross-sectional studies on retrospective metamemory abilities in participants within different stages of a schizophrenia spectrum disorder, with heterogeneous symptom severities, creating a pseudo-longitudinal overview...
2017: Frontiers in Psychology
https://www.readbyqxmd.com/read/28289277/csf-gaba-is-reduced-in-first-episode-psychosis-and-associates-to-symptom-severity
#2
F Orhan, H Fatouros-Bergman, M Goiny, A Malmqvist, F Piehl, S Cervenka, K Collste, P Victorsson, C M Sellgren, L Flyckt, S Erhardt, G Engberg
Schizophrenia is characterized by a multiplicity of symptoms arising from almost all domains of mental function. γ-Aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the brain and is increasingly recognized to have a significant role in the pathophysiology of the disorder. In the present study, cerebrospinal fluid (CSF) concentrations of GABA were analyzed in 41 first-episode psychosis (FEP) patients and 21 age- and sex-matched healthy volunteers by high-performance liquid chromatography...
March 14, 2017: Molecular Psychiatry
https://www.readbyqxmd.com/read/28261117/psychotropic-medication-and-substance-use-during-pregnancy-by-women-with-severe-mental-illness
#3
Kate J Brameld, Assen Jablensky, Jenny Griffith, John Dean, Vera A Morgan
BACKGROUND: Sociodemographic factors, alcohol and drug intake, and maternal health are known to be associated with adverse outcomes in pregnancy for women with severe mental illness in addition to their use of psychotropic medication. In this study, we describe the demographic characteristics of women hospitalized for severe mental illness along with their use of medication and other drugs during the pregnancy period. METHODS: A clinical case note review of women with psychosis who were hospitalized at the State Psychiatric Hospital in Western Australia during 1966-1996, gave birth between 1980 and 1992, and received psychiatric treatment during the pregnancy period...
2017: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/28243443/health-education-and-activity-lessening-the-inequalities-in-mental-health-hea-lti-mental-health
#4
Georgia Richmond, Conor Kenny, Jabed Ahmed, Lucy Stephenson, Jamie Lindsay, Patrick Earls, Donncha Mullin, Howard Ryland
Patients suffering from mental health illness have considerably more physical health disease burden than the rest of the population and are more likely to die 10 to 20 years younger compared with their peers. Diabetes, cardiovascular and respiratory disease have been recognised as contributing factors to premature death. Furthermore patients with severe mental illness undertake lower levels of physical activity. The aim of the project was therefore to address the inequalities in physical health that affect patients with mental health illness through designing and implementing a sustainable, transferable, patient-centred education and activity intervention...
2017: BMJ Quality Improvement Reports
https://www.readbyqxmd.com/read/28223807/the-relationship-between-childhood-trauma-and-adult-psychosis-in-a-uk-early-intervention-service-results-of-a-retrospective-case-note-study
#5
Francesca D Reeder, Nusrat Husain, Abdul Rhouma, Peter M Haddad, Tariq Munshi, Farooq Naeem, Davit Khachatryan, Imran B Chaudhry
AIM: There is evidence that childhood trauma is a risk factor for the development of psychosis and it is recommended that childhood trauma is inquired about in all patients presenting with psychosis. This study aimed to determine the prevalence of childhood trauma in patients in the UK Early Intervention Service based on a case note review. METHODS: This is a retrospective case note study of 296 patients in an UK Early Intervention Service. Trauma history obtained on service entry was reviewed and trauma experienced categorized...
2017: Neuropsychiatric Disease and Treatment
https://www.readbyqxmd.com/read/28155207/prodrome-or-risk-syndrome-what-s-in-a-name
#6
Pierre Alexis Geoffroy, Jan Scott
BACKGROUND: In the last decade, an increasing number of publications have examined the precursors of bipolar disorders (BD) and attempted to clarify the early origins and illness trajectory. This is a complex task as the evolution of BD often shows greater heterogeneity than psychosis, and the first onset episode of BD may be dominated by depressive or manic features or both. To date, most of the published reviews have not clarified whether they are focused on prodromes, risk syndromes or addressing both phenomena...
December 2017: International Journal of Bipolar Disorders
https://www.readbyqxmd.com/read/28124439/rates-of-criminal-victimization-in-an-early-intervention-for-psychosis-service-a-cross-sectional-survey
#7
Rowena Jones, Luke Banbury
BACKGROUND: There is a growing body of research looking into the high rates of victimization amongst people with severe mental illness. Studies to date have tended to look at victimization rates in people with chronic mental illness over a wide age range. However, national crime surveys indicate that younger people are more likely to be the victim of crime than older people. There is also evidence that people from ethnic minorities are more likely to experience and less likely to report criminal victimization...
January 26, 2017: Early Intervention in Psychiatry
https://www.readbyqxmd.com/read/28116752/psychological-interventions-for-post-traumatic-stress-disorder-ptsd-in-people-with-severe-mental-illness
#8
REVIEW
Jacqueline Sin, Debbie Spain, Marie Furuta, Trevor Murrells, Ian Norman
BACKGROUND: Increasing evidence indicates that individuals who develop severe mental illness (SMI) are also vulnerable to developing post-traumatic stress disorder (PTSD), due to increased risk of exposure to traumatic events and social adversity. The effectiveness of trauma-focused psychological interventions (TFPIs) for PTSD in the general population is well-established. TFPIs involve identifying and changing unhelpful beliefs about traumatic experiences, processing of traumatic memories, and developing new ways of responding to cues associated with trauma...
January 24, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28063397/clinical-and-treatment-related-determinants-of-subjective-quality-of-life-in-patients-with-first-episode-psychosis
#9
Vivian Wing Yan Kwong, Wing Chung Chang, Gloria Hoi Kei Chan, Olivia Tsz Ting Jim, Emily Sin Kei Lau, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Eric Yu Hai Chen
Subjective quality of life (SQoL) has been increasingly studied in first-episode psychosis (FEP). Prior research primarily examined the impact of psychiatric symptoms on SQoL. Relationship between treatment-related factors and SQoL is under-studied. In this study, 159 Chinese patients who had completed 2-year treatment from early intervention service in Hong Kong were recruited. Assessments on premorbid adjustment, clinical profiles including social anxiety measure, functioning, antipsychotic-induced extrapyramidal side-effects and attitude toward medication treatment were conducted...
March 2017: Psychiatry Research
https://www.readbyqxmd.com/read/28040575/stigma-toward-psychosis-and-its-formulation-process-prejudice-and-discrimination-against-early-stages-of-schizophrenia
#10
Yoko Baba, Takahiro Nemoto, Naohisa Tsujino, Taiju Yamaguchi, Naoyuki Katagiri, Masafumi Mizuno
BACKGROUND: Stigma toward psychosis can prevent social attendance and help-seeking behavior. Early detection and intervention has been shown to improve patient outcome in schizophrenia. The aim of this study was to reveal the characteristics and formulation process of stigma toward each clinical stage of schizophrenia, taking people's backgrounds into consideration. METHODS: The participants consisted of three groups: general public, patients with mental illness, and psychiatric professionals...
November 17, 2016: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28038921/community-treatment-order-identifying-the-need-for-more-evidence-based-justification-of-its-use-in-first-episode-psychosis-patients
#11
Stéphane Morandi, Philippe Golay, Martin Lambert, Benno G Schimmelmann, Patrick D McGorry, Sue M Cotton, Philippe Conus
OBJECTIVES: Community Treatment Order (CTO) is a legal regime that obliges patients suffering mental disorder to adhere to treatment in the community and allows for a swift admission to hospital if necessary. Study aims were to: (i) determine CTO frequency in a large representative sample of first episode psychosis (FEP) patients; (ii) compare the characteristics of patients with or without CTO before entry, during treatment and at discharge from an early psychosis program. METHODS: Information on 660 patients treated at the Early Psychosis Prevention and Intervention Centre (EPPIC) between 1998 and 2000 was collected from medical files...
December 27, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27991417/the-economic-burden-of-chronic-psychotic-disorders-in-ontario
#12
Claire de Oliveira, Joyce Cheng, Juergen Rehm, Paul Kurdyak
BACKGROUND: Chronic psychotic disorders are severe and disabling mental disorders associated with poor psychiatric and medical outcomes. These disorders are considered one of the most costly mental disorders due young age at onset and the need for intensive health care over the life course. AIMS OF THE STUDY: The purpose of this study was to estimate the direct health care costs of chronic psychotic disorders in Ontario in 2012 from the perspective of the third-party payer (i...
December 1, 2016: Journal of Mental Health Policy and Economics
https://www.readbyqxmd.com/read/27979719/admission-to-acute-mental-health-services-after-contact-with-crisis-resolution-and-home-treatment-teams-an-investigation-in-two-large-mental-health-care-providers
#13
Nomi Werbeloff, Chin-Kuo Chang, Matthew Broadbent, Joseph F Hayes, Robert Stewart, David P J Osborn
BACKGROUND: Crisis resolution and home treatment teams (CRTs) offer an alternative to hospital admission for patients undergoing mental health crises in the UK. Few studies have been done to examine predictors of relapse and readmission after contact with CRTs. METHODS: We used the Clinical Record Interactive Search to identify all patients receiving care from CRTs in two National Health Service (NHS) mental health trusts in London: Camden and Islington NHS Foundation Trust and South London and Maudsley NHS Foundation Trust...
January 2017: Lancet Psychiatry
https://www.readbyqxmd.com/read/27976370/droperidol-for-psychosis-induced-aggression-or-agitation
#14
REVIEW
Mariam A Khokhar, John Rathbone
BACKGROUND: People experiencing acute psychotic illnesses, especially those associated with agitated or violent behaviour, may require urgent pharmacological tranquillisation or sedation. Droperidol, a butyrophenone antipsychotic, has been used for this purpose in several countries. OBJECTIVES: To estimate the effects of droperidol, including its cost-effectiveness, when compared to placebo, other 'standard' or 'non-standard' treatments, or other forms of management of psychotic illness, in controlling acutely disturbed behaviour and reducing psychotic symptoms in people with schizophrenia-like illnesses...
December 15, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27951481/relatives-expressed-emotion-distress-and-attributions-in-clinical-high-risk-and-recent-onset-of-psychosis
#15
Tecelli Domínguez-Martínez, Cristina Medina-Pradas, Thomas R Kwapil, Neus Barrantes-Vidal
It has been well-demonstrated that Expressed Emotion (EE) in caregivers of schizophrenia patients is related to their illness attributions, but little is known about relatives' cognitive and emotional appraisals at early stages of psychosis. This study examined differences on the relationships of EE with distress and illness attributions in 78 relatives of At-Risk Mental States (ARMS) and First-Episode of Psychosis (FEP) patients, and which of those variables better predicted EE. Criticism and Emotional Over-Involvement (EOI) were associated with distress and with several illness attributions in both groups...
January 2017: Psychiatry Research
https://www.readbyqxmd.com/read/27913162/intranasal-delivery-of-antipsychotic-drugs
#16
REVIEW
Yogesh K Katare, Justin E Piazza, Jayant Bhandari, Ritesh P Daya, Kosalan Akilan, Madeline J Simpson, Todd Hoare, Ram K Mishra
Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article, we review the mechanisms and methods used for brain targeting via the intranasal (IN) route as well as the potential advantages of improving this type of delivery. We extensively review experimental studies relevant to intranasal delivery of therapeutic agents for the treatment of psychosis and mental illnesses...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27889383/a-systematic-review-examining-factors-predicting-favourable-outcome-in-cognitive-behavioural-interventions-for-psychosis
#17
REVIEW
J O'Keeffe, R Conway, B McGuire
Psychosis is a debilitating mental health condition affecting approximately 4 persons per 1000. Cognitive behavioural therapy for psychosis (CBTp) has been shown to be an effective treatment for psychosis and is recommended by several national guidelines. CBTp does not work equally well with everyone, however, with some 50% of clients receiving little benefit. This review sets out to systematically assess the literature and methodological quality of a number of studies, which examine factors predicting successful outcome in CBTp...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27881965/fundamental-role-of-methylenetetrahydrofolate-reductase-677-c%C3%A2-%C3%A2-%C3%A2-t-genotype-and-flavin-compounds-in-biochemical-phenotypes-for-schizophrenia-and-schizoaffective-psychosis
#18
Stephanie Fryar-Williams
The Mental Health Biomarker Project (2010-2016) explored variables for psychosis in schizophrenia and schizoaffective disorder. Blood samples from 67, highly characterized symptomatic cases and 67 gender and age matched control participants were analyzed for methyl tetrahydrofolate reductase (MTHFR) 677C → T gene variants and for vitamin B6, B12 and D, folate, unbound copper, zinc cofactors for enzymes in the methylation cycle, and related catecholamine pathways. Urine samples were analyzed for indole-catecholamines, their metabolites, and oxidative-stress marker, hydroxylpyrolline-2-one (HPL)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27878322/assessing-needs-for-psychiatric-treatment-in-prisoners-1-prevalence-of-disorder
#19
Paul Bebbington, Sharon Jakobowitz, Nigel McKenzie, Helen Killaspy, Rachel Iveson, Gary Duffield, Mark Kerr
BACKGROUND: High levels of psychiatric morbidity in prisoners have important implications for services. Assessing Needs for Psychiatric Treatment in Prisoners is an evaluation of representative samples of prisoners in a male and a female prison in London. This paper reports on the prevalence of mental disorders. In a companion paper, we describe how this translates into mental health treatment needs and the extent to which they have been met. METHODS: Prisoners were randomly sampled in a sequential procedure based on the Local Inmate Data System...
February 2017: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27876684/do-we-still-have-a-digital-divide-in-mental-health-a-five-year-survey-follow-up
#20
Dan Robotham, Safarina Satkunanathan, Lisa Doughty, Til Wykes
BACKGROUND: Nearly everyone in society uses the Internet in one form or another. The Internet is heralded as an efficient way of providing mental health treatments and services. However, some people are still excluded from using Internet-enabled technology through lack of resources, skills, and confidence. OBJECTIVE: Five years ago, we showed that people with severe mental illness were at risk of digital exclusion, especially middle-aged patients with psychosis and/or people from black or minority ethnic groups with psychosis...
November 22, 2016: Journal of Medical Internet Research
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