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https://www.readbyqxmd.com/read/27913162/intranasal-delivery-of-antipsychotic-drugs
#1
REVIEW
Yogesh K Katare, Justin E Piazza, Jayant Bhandari, Ritesh P Daya, Kosalan Akilan, Madeline J Simpson, Todd Hoare, Ram K Mishra
Antipsychotic drugs are used to treat psychotic disorders that afflict millions globally and cause tremendous emotional, economic and healthcare burdens. However, the potential of intranasal delivery to improve brain-specific targeting remains unrealized. In this article, we review the mechanisms and methods used for brain targeting via the intranasal (IN) route as well as the potential advantages of improving this type of delivery. We extensively review experimental studies relevant to intranasal delivery of therapeutic agents for the treatment of psychosis and mental illnesses...
November 29, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27889383/a-systematic-review-examining-factors-predicting-favourable-outcome-in-cognitive-behavioural-interventions-for-psychosis
#2
REVIEW
J O'Keeffe, R Conway, B McGuire
Psychosis is a debilitating mental health condition affecting approximately 4 persons per 1000. Cognitive behavioural therapy for psychosis (CBTp) has been shown to be an effective treatment for psychosis and is recommended by several national guidelines. CBTp does not work equally well with everyone, however, with some 50% of clients receiving little benefit. This review sets out to systematically assess the literature and methodological quality of a number of studies, which examine factors predicting successful outcome in CBTp...
November 23, 2016: Schizophrenia Research
https://www.readbyqxmd.com/read/27881965/fundamental-role-of-methylenetetrahydrofolate-reductase-677-c%C3%A2-%C3%A2-%C3%A2-t-genotype-and-flavin-compounds-in-biochemical-phenotypes-for-schizophrenia-and-schizoaffective-psychosis
#3
Stephanie Fryar-Williams
The Mental Health Biomarker Project (2010-2016) explored variables for psychosis in schizophrenia and schizoaffective disorder. Blood samples from 67, highly characterized symptomatic cases and 67 gender and age matched control participants were analyzed for methyl tetrahydrofolate reductase (MTHFR) 677C → T gene variants and for vitamin B6, B12 and D, folate, unbound copper, zinc cofactors for enzymes in the methylation cycle, and related catecholamine pathways. Urine samples were analyzed for indole-catecholamines, their metabolites, and oxidative-stress marker, hydroxylpyrolline-2-one (HPL)...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27878322/assessing-needs-for-psychiatric-treatment-in-prisoners-1-prevalence-of-disorder
#4
Paul Bebbington, Sharon Jakobowitz, Nigel McKenzie, Helen Killaspy, Rachel Iveson, Gary Duffield, Mark Kerr
BACKGROUND: High levels of psychiatric morbidity in prisoners have important implications for services. Assessing Needs for Psychiatric Treatment in Prisoners is an evaluation of representative samples of prisoners in a male and a female prison in London. This paper reports on the prevalence of mental disorders. In a companion paper, we describe how this translates into mental health treatment needs and the extent to which they have been met. METHODS: Prisoners were randomly sampled in a sequential procedure based on the Local Inmate Data System...
November 22, 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27876684/do-we-still-have-a-digital-divide-in-mental-health-a-five-year-survey-follow-up
#5
Dan Robotham, Safarina Satkunanathan, Lisa Doughty, Til Wykes
BACKGROUND: Nearly everyone in society uses the Internet in one form or another. The Internet is heralded as an efficient way of providing mental health treatments and services. However, some people are still excluded from using Internet-enabled technology through lack of resources, skills, and confidence. OBJECTIVE: Five years ago, we showed that people with severe mental illness were at risk of digital exclusion, especially middle-aged patients with psychosis and/or people from black or minority ethnic groups with psychosis...
November 22, 2016: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/27809822/primary-psychosis-and-borna-disease-virus-infection-in-lithuania-a-case-control-study
#6
Violeta Zaliunaite, Vesta Steibliene, Liv Bode, Aurelija Podlipskyte, Robertas Bunevicius, Hanns Ludwig
BACKGROUND: The hypothesis that microbial infections may be linked to mental disorders has long been addressed for Borna disease virus (BDV), but clinical and epidemiological evidence remained inconsistent due to non-conformities in detection methods. BDV circulating immune complexes (CIC) were shown to exceed the prevalence of serum antibodies alone and to comparably screen for infection in Europe (DE, CZ, IT), the Middle East (IR) and Asia (CN), still seeking general acceptance. METHODS: We used CIC and antigen (Ag) tests to investigate BDV infection in Lithuania through a case-control study design comparing in-patients suffering of primary psychosis with blood donors...
November 3, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27783129/the-association-between-continuity-of-care-and-readmission-to-hospital-in-patients-with-severe-psychosis
#7
Stephen Robert Puntis, Jorun Rugkåsa, Tom Burns
PURPOSE: Providing good continuity of care to patients is considered a vital component of community mental health services, but there is limited evidence that it is associated with good outcomes. We measured service use and a multidimensional concept of continuity of care in 323 patients who were to be discharged from hospital following compulsory treatment for psychosis to investigate the association between continuity and rehospitalisation. METHODS: We conducted a 36-month prospective cohort study of the patients recruited to the Oxford Community Treatment Order Trial (OCTET)...
December 2016: Social Psychiatry and Psychiatric Epidemiology
https://www.readbyqxmd.com/read/27719778/assessment-and-care-of-childbearing-women-with-severe-and-persistent-mental-illness
#8
Amy McKeever, SueEllen Alderman, Stephanie Luff, Brian DeJesus
Severe and persistent mental illness (SPMI) refers to complex mood disorders that include major depressive disorder with or without psychosis; severe anxiety disorders resistant to treatment; affective psychotic disorders including bipolar affective disorder, schizophrenia, and schizoaffective disorder; and other nonaffective subtypes of schizophrenia. SPMIs affect 1 in 17 people and are among the leading causes of disability and impaired health-related quality of life in the United States. Caring for childbearing women with preexisting SPMI can be challenging for maternal-child health clinicians...
October 2016: Nursing for Women's Health
https://www.readbyqxmd.com/read/27703759/auditory-verbal-hallucinations-in-first-episode-psychosis-a-phenomenological-investigation
#9
Rachel Upthegrove, Jonathan Ives, Matthew R Broome, Kimberly Caldwell, Stephen J Wood, Femi Oyebode
BACKGROUND: In dimensional understanding of psychosis, auditory verbal hallucinations (AVH) are unitary phenomena present on a continuum from non-clinical voice hearing to severe mental illness. There is mixed evidence for this approach and a relative absence of research into subjective experience of AVH in early psychosis. AIMS: To conduct primary research into the nature of subjective experience of AVH in first-episode psychosis. METHOD: A phenomenological study using diary and photo-elicitation qualitative techniques investigating the subjective experience of AVH in 25 young people with first-episode psychosis...
January 2016: BJPsych Open
https://www.readbyqxmd.com/read/27691375/utilization-and-cost-of-health-care-services-during-the-first-episode-of-psychosis
#10
Emily Liffick, Nicole F Mehdiyoun, Jenifer L Vohs, Michael M Francis, Alan Breier
OBJECTIVE: Because of the chronicity, severity, and marked psychosocial impairment that may characterize the illness, schizophrenia is an incredibly costly disease. Recent data indicate that intervention earlier in the course of schizophrenia produces cost savings. This study compared health service utilization and associated costs for patients receiving treatment for first-episode psychosis (FEP) delivered within the early-intervention (EI) model at the Prevention and Recovery Center for Early Psychosis (PARC) and for a matched sample of FEP patients receiving treatment as usual at a geographically similar mental health clinic...
October 3, 2016: Psychiatric Services: a Journal of the American Psychiatric Association
https://www.readbyqxmd.com/read/27683283/duration-of-untreated-psychosis-in-an-egyptian-sample-sociodemographic-and-clinical-variables
#11
Tarek Okasha, Nivert Zaki, Marwa Abd El Meguid, Marwa El-Missiry, Walaa Sabry, Mostafa Kamel Ismaeil, Samar M Fouad
BACKGROUND: Duration of untreated psychosis (DUP) has been considered as a poor prognostic factor for psychotic disorder. Several studies have been investigating different predictors of DUP in Western countries, while in Egypt only a few studies have examined various predictors of DUP. AIMS: To study DUP in Egyptian patients with psychotic disorders and to investigate how certain illnesses, patient, socio-cultural risk factors and help-seeking behaviour are correlated with prolonged DUP...
September 28, 2016: International Journal of Social Psychiatry
https://www.readbyqxmd.com/read/27636364/-treatment-at-home-in-lengerich-westfalia-a-model-of-community-based-mental-health-care
#12
E Sakellaridou, C Chrysanthou, A Nienaber
We examined the effectiveness of a new homebased integrated care intervention model for patients with multiple-episode psychosis in a rural area in Germany, which combines elements of 2 other well-defined interventions: Assertive Community Treatment and Home Treatment. The pilot evaluation was conducted in 2 steps, using a quantitative and a qualitative design. In a 24-month follow-up period, patients showed significant improvement in symptoms, illness severity, global functioning and quality of life, as well as larger reduction in the number of days of inpatient treatment needed...
September 16, 2016: Das Gesundheitswesen
https://www.readbyqxmd.com/read/27623121/-advocacy-for-the-establishment-of-a-comprehensive-strategy-to-reduce-the-burden-of-schizophrenic-disorders
#13
D Leguay
This article attempts to identify and put into perspective the different approaches that could globally prevent the suffering induced by schizophrenia, from the detection of early psychosis to the impact on individual and family functioning and emotional health. Schizophrenia causes, at the community level, a number of difficult consequences and associated costs, which likely could be reduced if specific strategies, already known and documented internationally, were applied. Two areas not explored in this article: the role of medication and the issue of suicide prevention...
September 9, 2016: L'Encéphale
https://www.readbyqxmd.com/read/27616996/utility-of-washington-early-recognition-center-self-report-screening-questionnaires-in-the-assessment-of-patients-with-schizophrenia-and-bipolar-disorder
#14
Christina J Hsieh, Douglass Godwin, Daniel Mamah
Early identification and treatment are associated with improved outcomes in bipolar disorder (BPD) and schizophrenia (SCZ). Screening for the presence of these disorders usually involves time-intensive interviews that may not be practical in settings where mental health providers are limited. Thus, individuals at earlier stages of illness are often not identified. The Washington Early Recognition Center Affectivity and Psychosis (WERCAP) screen is a self-report questionnaire originally developed to identify clinical risk for developing bipolar or psychotic disorders...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27599617/polysubstance-induced-relapse-of-schizoaffective-disorder-refractory-to-high-dose-antipsychotic-medications-a-case-report
#15
Murray G Tucker, Sebastian Kekulawala, Michelle Kent, Sam Mostafa, Richard Harvey
BACKGROUND: The high prevalence of comorbid illicit drug use in persons with chronic psychotic illness represents a strong determinant of psychotic relapse and rehospitalization. Epidemiological studies indicate changing patterns of illicit drug use in Australia, which are concerning because of increased use of crystal methamphetamine, also known as "ice." An important complication of habitual use of crystal methamphetamine is the development of a dose-dependent acute psychotic reaction...
2016: Journal of Medical Case Reports
https://www.readbyqxmd.com/read/27598954/-ethical-aspects-of-medical-thought-on-the-madness-in-the-enlightenment
#16
REVIEW
Mariano Martini, Ilaria Gorini, Marta Licata, Francesco De Stefano, Michele Schiavone, Rosagemma Ciliberti
The seventeenth century is a period of transition from religious views that are not authentic but dogmatic about demonic influences to the application of scientific and methodological criteria in science. During Enlightenment there was an approach heavily influenced by ethical issues. In this context, there is a rational recognition of the value of man free from the teleological type references. Mental illnesses are treated using scientific criteria. During the seventeenth century clinical interest is also extended to psychosis and not only to neurosis...
August 2016: Acta Medico-historica Adriatica: AMHA
https://www.readbyqxmd.com/read/27576933/acute-mental-disorders-and-short-and-long-term-morbidity-in-patients-with-third-degree-flame-burn-a-population-based-outcome-study-of-96-451-patients-from-the-nationwide-inpatient-sample-nis-database-2001-2011
#17
Krishnaraj Mahendraraj, Diane M Durgan, Ronald S Chamberlain
BACKGROUND: Although burn patients with preexisting mood disorders have been shown to have diminished clinical recovery, acute mental disorders (AMD) are often unrecognized despite a link with post-traumatic stress disorder and social maladjustment later on. This study assessed the clinical profile of a large cohort of burn patients who developed AMD compared to those with chronic mental illness (CMI) and those without mental health problems to assess the impact of AMI on burn outcomes...
August 28, 2016: Burns: Journal of the International Society for Burn Injuries
https://www.readbyqxmd.com/read/27570512/suicide-during-perinatal-period-epidemiology-risk-factors-and-clinical-correlates
#18
REVIEW
Laura Orsolini, Alessandro Valchera, Roberta Vecchiotti, Carmine Tomasetti, Felice Iasevoli, Michele Fornaro, Domenico De Berardis, Giampaolo Perna, Maurizio Pompili, Cesario Bellantuono
Perinatal period may pose a great challenge for the clinical management and treatment of psychiatric disorders in women. In fact, several mental illnesses can arise during pregnancy and/or following childbirth. Suicide has been considered a relatively rare event during the perinatal period. However, in some mental disorders (i.e., postpartum depression, bipolar disorder, postpartum psychosis, etc.) have been reported a higher risk of suicidal ideation, suicide attempt, or suicide. Therefore, a complete screening of mothers' mental health should also take into account thoughts of suicide and thoughts about harming infants as well...
2016: Frontiers in Psychiatry
https://www.readbyqxmd.com/read/27554461/-why-and-how-to-treat-psychosis-earlier
#19
Vincent Laprevote, Ulrike Heitz, Paolo Di Patrizio, Erich Studerus, Fabienne Ligier, Thomas Schwitzer, Raymund Schwan, Anita Riecher-Rössler
Chronic psychosis, as for instance schizophrenia, usually begins in young adulthood and may cause severe disability. It causes a mean loss of life expectancy of 22 years. Actual models of psychosis do not trace the beginning of psychosis to the first franc psychotic episode only, but to earlier symptoms. In a classical health system only considering the first psychotic episode, the mean duration of untreated illness (DUI) can last several years. Yet this DUI has a direct impact on the prognosis of the disease...
August 20, 2016: La Presse Médicale
https://www.readbyqxmd.com/read/27491966/explanatory-model-of-psychosis-impact-on-perception-of-self-stigma-by-patients-in-three-sub-saharan-african-cities
#20
Victor Makanjuola, Yomi Esan, Bibilola Oladeji, Lola Kola, John Appiah-Poku, Benjamin Harris, Caleb Othieno, Leshawndra Price, Soraya Seedat, Oye Gureje
BACKGROUND: Most cultures in sub-Saharan Africa subscribe to the belief that the root cause of psychosis is supernatural. Individuals in the community who hold a religiomagical explanatory model of causation have been shown to exhibit more stigmatizing attitudes towards people with psychosis. Self-stigma among individuals with psychosis is less frequently studied. METHOD: We used a mixed-method approach, consisting of key informant's interviews to elicit information on explanatory models of causation of psychosis and questionnaire assessment of internalized stigma with an adapted version of the Scale for Internalized Stigma of Mental Illness...
December 2016: Social Psychiatry and Psychiatric Epidemiology
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