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https://www.readbyqxmd.com/read/29441009/autophagy-and-alzheimer-s-disease-from-molecular-mechanisms-to-therapeutic-implications
#1
REVIEW
Md Sahab Uddin, Anna Stachowiak, Abdullah Al Mamun, Nikolay T Tzvetkov, Shinya Takeda, Atanas G Atanasov, Leandro B Bergantin, Mohamed M Abdel-Daim, Adrian M Stankiewicz
Alzheimer's disease (AD) is the most common cause of progressive dementia in the elderly. It is characterized by a progressive and irreversible loss of cognitive abilities and formation of senile plaques, composed mainly of amyloid β (Aβ), and neurofibrillary tangles (NFTs), composed of tau protein, in the hippocampus and cortex of afflicted humans. In brains of AD patients the metabolism of Aβ is dysregulated, which leads to the accumulation and aggregation of Aβ. Metabolism of Aβ and tau proteins is crucially influenced by autophagy...
2018: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/29404826/neurological-complications-of-acute-and-chronic-sinusitis
#2
REVIEW
Andrea Ziegler, Monica Patadia, James Stankiewicz
PURPOSE OF REVIEW: Acute and chronic sinusitis can give rise to a wide array of intracranial and orbital complications. These complications include brain abscess, subdural empyema, epidural abscess, meningitis, venous sinus thrombosis, frontal bone osteomyelitis, and orbital cellulitis and abscess. Despite numerous medical advances, these complications carry a risk of mortality and significant morbidity. RECENT FINDINGS: Recent studies have shown improvement in both the mortality and the morbidity associated with the neurologic complications of acute and chronic sinusitis...
February 5, 2018: Current Neurology and Neuroscience Reports
https://www.readbyqxmd.com/read/29304497/predictors-of-hematological-abnormalities-in-multiple-sclerosis-patients-treated-with-fingolimod-and-dimethyl-fumarate-and-impact-of-treatment-switch-on-lymphocyte-and-leukocyte-count
#3
M Baharnoori, C T Gonzalez, A Chua, C Diaz-Cruz, B C Healy, J Stankiewicz, H L Weiner, T Chitnis
BACKGROUND: There is limited data regarding the predictors of hematological abnormalities in multiple sclerosis (MS) patients treated with dimethyl fumarate (DMF) or fingolimod (FNG), and the impact of treatment switch on lymphocyte and leukocyte count METHODS: We identified 405 patients on DMF and 300 patients on FNG (treatment duration: at least 12 month) within a large prospective study of MS patients conducted at the Partners MS Center, Brigham and Women's Hospital (CLIMB study) between Jan 2011 to Feb 2016...
December 14, 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/29297184/an-algorithm-for-preoperative-differential-diagnostics-of-parotid-tumors-on-the-basis-of-their-dynamic-and-diffusion-weighted-mr-images-a-retrospective-analysis-of-158-cases
#4
Bogusław Mikaszewski, Karolina Markiet, Aneta Smugała, Dominik Stodulski, Edyta Szurowska, Czesław Stankiewicz
BACKGROUND: To verify the usefulness of a new algorithm for preoperative differential diagnostics of parotid tumors on the basis of their dynamic and diffusion-weighted MR images. METHODS: The retrospective analysis included 158 consecutive surgical patients with parotid tumors. Aside from ultrasound-guided fine needle biopsy, the protocol of preoperative evaluation included dynamic and diffusion-weighted MRI. According to the new diagnostic algorithm, the result of fine needle biopsy was considered only in the case of lesions with time to peak enhancement (Tpeak) > 60 s and washout rate (WR) ≤ 30% on dynamic MRI and apparent diffusion coefficient (ADC) ≤ 1...
January 3, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29297183/the-sonographic-morphology-of-musculus-palmaris-longus-in-humans
#5
Krzysztof P Dąbrowski, Hanna Stankiewicz-Jóźwicka, Arkadiusz Kowalczyk, Michał Markuszewski, Bogdan Ciszek
BACKGROUND: The aim of this work was to describe morphology and morphometry of musculus palmaris longus and compare the outcome of Shaeffer's test with ultrasound imaging. MATERIALS AND METHODS: 40 forearms of 20 healthy volunteers (11 females, 9 males) were tested by Shaeffer's test and ultrasound imaging. Anthropological measurements of the forearm and ultrasound guided measurements of musculus palmaris longus were taken. The outcome was tested for statistical significance by Fisher's test...
January 3, 2018: Folia Morphologica (Warsz)
https://www.readbyqxmd.com/read/29296863/management-of-thrombotic-thrombocytopenic-purpura-without-plasma-exchange-the-jehovah-s-witness-experience
#6
James N George, Steven A Sandler, Joanna Stankiewicz
TTP in Jehovah's Witness patients has been managed successfully without PEX.This experience, plus new TTP treatments, may make it possible for patients who are not Jehovah's Witnesses to avoid PEX in the future.
November 14, 2017: Blood Advances
https://www.readbyqxmd.com/read/29295521/molecular-targets-for-components-of-essential-oils-in-the-insect-nervous-system-a-review
#7
REVIEW
Milena Jankowska, Justyna Rogalska, Joanna Wyszkowska, Maria Stankiewicz
Essential oils (EOs) are lipophilic secondary metabolites obtained from plants; terpenoids represent the main components of them. A lot of studies showed neurotoxic actions of EOs. In insects, they cause paralysis followed by death. This feature let us consider components of EOs as potential bioinsecticides. The inhibition of acetylcholinesterase (AChE) is the one of the most investigated mechanisms of action in EOs. However, EOs are rather weak inhibitors of AChE. Another proposed mechanism of EO action is a positive allosteric modulation of GABA receptors (GABArs)...
December 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29284237/effect-of-3-year-education-in-the-main-fire-service-school-on-the-fitness-level-of-students
#8
Andrzej Tomczak, Jerzy Bertrandt, Anna Kłos, Wiesława Szymańska, Wanda Stankiewicz
INTRODUCTION AND OBJECTIVE: The aim of the study was to determine changes in the fitness level among students of the Main Fire Service School during 3-year's education. MATERIAL AND METHODS: A total of 75 male and 5 female students took part in the study. Fitness level measurements were carried out before beginning the studies (Measurement 0) and after the 1st, 2nd and 3rd years at the school (Measurement 1, 2, 3). The following tests were performed to estimate level of physical fitness for men: pull-ups on a bar, a 50 m sprint and 1,000 m run, and for women: sit-ups, medical ball (2 kg) throw from above the head and a 4 x10 m shuttle run...
December 23, 2017: Annals of Agricultural and Environmental Medicine: AAEM
https://www.readbyqxmd.com/read/29274753/multiple-sclerosis-re-examined-essential-and-emerging-clinical-concepts
#9
REVIEW
Jonathan Zurawski, James Stankiewicz
Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system characterized by exacerbations of neurological dysfunction due to inflammatory demyelination. Neurologic symptoms typically present in young adulthood and vary based on the site of inflammation, though weakness, sensory impairment, brainstem dysfunction and vision loss are common. MS occurs more frequently in women and its development is complex-genetics, hormones, geography, vitamin D, and viral exposure all play roles. Early MS is characterized by relapsing-remitting course and inflammation of the white matter though as patients age, the disease often transitions to a pathologically distinct secondary progressive phase with gradual disability accrual affecting gait, coordination and bladder function...
December 21, 2017: American Journal of Medicine
https://www.readbyqxmd.com/read/29198536/infants-with-atypical-presentations-of-alveolar-capillary-dysplasia-with-misalignment-of-the-pulmonary-veins-who-underwent-bilateral-lung-transplantation
#10
Christopher T Towe, Frances V White, R Mark Grady, Stuart C Sweet, Pirooz Eghtesady, Daniel J Wegner, Partha Sen, Przemyslaw Szafranski, Pawel Stankiewicz, Aaron Hamvas, F Sessions Cole, Jennifer A Wambach
OBJECTIVE: To describe disease course, histopathology, and outcomes for infants with atypical presentations of alveolar capillary dysplasia with misalignment of the pulmonary veins (ACDMPV) who underwent bilateral lung transplantation. STUDY DESIGN: We reviewed clinical history, diagnostic studies, explant histology, genetic sequence results, and post-transplant course for 6 infants with atypical ACDMPV who underwent bilateral lung transplantation at St. Louis Children's Hospital...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29191981/impact-of-training-state-on-fasting-induced-regulation-of-adipose-tissue-metabolism-in-humans
#11
Lærke Bertholdt, Anders Gudiksen, Tomasz Stankiewicz, Ida Villesen, Jonas Tybirk, Gerrit van Hall, Jens Bangsbo, Peter Plomgaard, Henriette Pilegaard
Recruitment of fatty acids from adipose tissue is essential during fasting. However, the molecular mechanisms behind fasting-induced metabolic regulation in human adipose tissue and the potential impact of training state in this are unknown. Therefore, the aim of the present study was to investigate 1) fasting-induced regulation of lipolysis and glyceroneogenesis in human adipose tissue as well as 2) the impact of training state on basal oxidative capacity and fasting-induced metabolic regulation in human adipose tissue...
November 30, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29180230/glucocorticoids-genes-and-brain-function
#12
REVIEW
Grzegorz R Juszczak, Adrian M Stankiewicz
The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined with biochemical and physiological data to create an integrated view of the effects induced by GCs. The most frequently reported genes were Errfi1 and Ddit4. Their up-regulation was associated with the altered transcription of genes regulating growth factor and mTORC1 signaling (Gab1, Tsc22d3, Dusp1, Ndrg2, Ppp5c and Sesn1) and progression of the cell cycle (Ccnd1, Cdkn1a and Cables1)...
November 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29170599/complexity-and-challenges-in-noncontact-high-temperature-measurements-in-microwave-assisted-catalytic-reactors
#13
Lalit S Gangurde, Guido S J Sturm, Tushar J Devadiga, Andrzej I Stankiewicz, Georgios D Stefanidis
The complexity and challenges in noncontact temperature measurements inside microwave-heated catalytic reactors are presented in this paper. A custom-designed microwave cavity has been used to focus the microwave field on the catalyst and enable monitoring of the temperature field in 2D. A methodology to study the temperature distribution in the catalytic bed by using a thermal camera in combination with a thermocouple for a heterogeneous catalytic reaction (methane dry reforming) under microwave heating has been demonstrated...
November 15, 2017: Industrial & Engineering Chemistry Research
https://www.readbyqxmd.com/read/29125681/2015-16-i-move-i-move-multicentre-case-control-study-in-europe-moderate-vaccine-effectiveness-estimates-against-influenza-a-h1n1-pdm09-and-low-estimates-against-lineage-mismatched-influenza-b-among-children
#14
Esther Kissling, Marta Valenciano, Francisco Pozo, Ana-Maria Vilcu, Annicka Reuss, Caterina Rizzo, Amparo Larrauri, Judit Krisztina Horváth, Mia Brytting, Lisa Domegan, Monika Korczyńska, Adam Meijer, Ausenda Machado, Alina Ivanciuc, Vesna Višekruna Vučina, Sylvie van der Werf, Brunhilde Schweiger, Antonino Bella, Alin Gherasim, Annamária Ferenczi, Katherina Zakikhany, Joan O Donnell, Iwona Paradowska-Stankiewicz, Frederika Dijkstra, Raquel Guiomar, Mihaela Lazar, Sanja Kurečić Filipović, Kari Johansen, Alain Moren
BACKGROUND: During the 2015/16 influenza season in Europe, the co-circulating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine. METHODS: We used the test negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza...
November 10, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29075976/specific-plasma-amino-acid-disturbances-associated-with-metabolic-syndrome
#15
Marta Siomkajło, Jacek Rybka, Magdalena Mierzchała-Pasierb, Andrzej Gamian, Joanna Stankiewicz-Olczyk, Marek Bolanowski, Jacek Daroszewski
PURPOSE: The primary objective of the present study was to examine the association between branched chain and aromatic amino acid profiles (BCAA and AAA respectively) and the metabolic syndrome (MS), and to evaluate the clinical utility of these associations in the diagnostic process. METHODS: Two hundred and sixty three healthy men with MS [MS(+): n = 165] and without MS [MS(-): n = 98] were enrolled in the observational study. Anthropometrical, biochemical, and amino acid measurements were performed...
October 26, 2017: Endocrine
https://www.readbyqxmd.com/read/29072584/impaired-sleep-circadian-rhythms-and-neurogenesis-in-diet-induced-premature-aging
#16
Alexander J Stankiewicz, Erin M McGowan, Lili Yu, Irina V Zhdanova
Chronic high caloric intake (HCI) is a risk factor for multiple major human disorders, from diabetes to neurodegeneration. Mounting evidence suggests a significant contribution of circadian misalignment and sleep alterations to this phenomenon. An inverse temporal relationship between sleep, activity, food intake, and clock mechanisms in nocturnal and diurnal animals suggests that a search for effective therapeutic approaches can benefit from the use of diurnal animal models. Here, we show that, similar to normal aging, HCI leads to the reduction in daily amplitude of expression for core clock genes, a decline in sleep duration, an increase in scoliosis, and anxiety-like behavior...
October 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29059667/-life-saving-cricothyroidotomy-in-throat-and-laryngeal-injuries-case-study
#17
Maja Chrzanowska-Wąsik, Leszek Sobiech, Vadim Matsibora, Tomasz Stankiewicz, Mariusz Goniewicz, Kamil Bednarz, Patryk Rzońca
The percentage of laryngeal injuries managed by hospital emergency departments is low. Currently, with the Emergency Medical Services working more efficiently, diagnostic imaging tools being more available and more precise surgical procedures after the injury, the mortality and disability rate among trauma victims is systematically decreasing. The given paper presents a case of a multiple organ trauma, including trauma to the larynx and throat, experienced during agricultural works. Life-saving surgical cricothyroidotomy using a tracheal tube was performed after preliminary diagnosis of the patient...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29016504/accuracy-of-four-imaging-techniques-for-diagnosis-of-posterior-pelvic-floor-disorders
#18
Isabelle M A van Gruting, Aleksandra Stankiewicz, Kirsten Kluivers, Riccardo De Bin, Helena Blake, Abdul H Sultan, Ranee Thakar
OBJECTIVE: To establish the diagnostic test accuracy of evacuation proctography, magnetic resonance imaging (MRI), transperineal ultrasonography, and endovaginal ultrasonography for detecting posterior pelvic floor disorders (rectocele, enterocele, intussusception, and anismus) in women with obstructed defecation syndrome and secondarily to identify the most patient-friendly imaging technique. METHODS: In this prospective cohort study, 131 women with symptoms of obstructed defecation syndrome underwent evacuation proctogram, MRI, and transperineal and endovaginal ultrasonography...
November 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28985207/erratum-thermoneutral-housing-exacerbates-nonalcoholic-fatty-liver-disease-in-mice-and-allows-for-sex-independent-disease-modeling
#19
Daniel A Giles, Maria E Moreno-Fernandez, Traci E Stankiewicz, Simon Graspeuntner, Monica Cappelletti, David Wu, Rajib Mukherjee, Calvin C Chan, Matthew J Lawson, Jared Klarquist, Annika Sünderhauf, Samir Softic, C Ronald Kahn, Kerstin Stemmer, Yoichiro Iwakura, Bruce J Aronow, Rebekah Karns, Kris A Steinbrecher, Christopher L Karp, Rachel Sheridan, Shiva K Shanmukhappa, Damien Reynaud, David B Haslam, Christian Sina, Jan Rupp, Simon P Hogan, Senad Divanovic
This corrects the article DOI: 10.1038/nm.4346.
October 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28942966/haploinsufficiency-of-the-chromatin-remodeler-bptf-causes-syndromic-developmental-and-speech-delay-postnatal-microcephaly-and-dysmorphic-features
#20
Paweł Stankiewicz, Tahir N Khan, Przemyslaw Szafranski, Leah Slattery, Haley Streff, Francesco Vetrini, Jonathan A Bernstein, Chester W Brown, Jill A Rosenfeld, Surya Rednam, Sarah Scollon, Katie L Bergstrom, Donald W Parsons, Sharon E Plon, Marta W Vieira, Caio R D C Quaio, Wagner A R Baratela, Johanna C Acosta Guio, Ruth Armstrong, Sarju G Mehta, Patrick Rump, Rolph Pfundt, Raymond Lewandowski, Erica M Fernandes, Deepali N Shinde, Sha Tang, Juliane Hoyer, Christiane Zweier, André Reis, Carlos A Bacino, Rui Xiao, Amy M Breman, Janice L Smith, Nicholas Katsanis, Bret Bostwick, Bernt Popp, Erica E Davis, Yaping Yang
Bromodomain PHD finger transcription factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISWI chromatin-remodeling complex. However, the clinical consequences of disruption of this complex remain largely uncharacterized. BPTF is required for anterior-posterior axis formation of the mouse embryo and was shown to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 expression in zebrafish. Here, we report eight loss-of-function and two missense variants (eight de novo and two of unknown origin) in BPTF on 17q24...
October 5, 2017: American Journal of Human Genetics
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