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https://www.readbyqxmd.com/read/29198536/infants-with-atypical-presentations-of-alveolar-capillary-dysplasia-with-misalignment-of-the-pulmonary-veins-who-underwent-bilateral-lung-transplantation
#1
Christopher T Towe, Frances V White, R Mark Grady, Stuart C Sweet, Pirooz Eghtesady, Daniel J Wegner, Partha Sen, Przemyslaw Szafranski, Pawel Stankiewicz, Aaron Hamvas, F Sessions Cole, Jennifer A Wambach
OBJECTIVE: To describe disease course, histopathology, and outcomes for infants with atypical presentations of alveolar capillary dysplasia with misalignment of the pulmonary veins (ACDMPV) who underwent bilateral lung transplantation. STUDY DESIGN: We reviewed clinical history, diagnostic studies, explant histology, genetic sequence results, and post-transplant course for 6 infants with atypical ACDMPV who underwent bilateral lung transplantation at St. Louis Children's Hospital...
November 30, 2017: Journal of Pediatrics
https://www.readbyqxmd.com/read/29191981/impact-of-training-state-on-fasting-induced-regulation-of-adipose-tissue-metabolism-in-humans
#2
Lærke Bertholdt, Anders Gudiksen, Tomasz Stankiewicz, Ida Villesen, Jonas Tybirk, Gerrit van Hall, Jens Bangsbo, Peter Plomgaard, Henriette Pilegaard
Recruitment of fatty acids from adipose tissue is essential during fasting. However, the molecular mechanisms behind fasting-induced metabolic regulation in human adipose tissue and the potential impact of training state in this are unknown. Therefore, the aim of the present study was to investigate 1) fasting-induced regulation of lipolysis and glyceroneogenesis in human adipose tissue as well as 2) the impact of training state on basal oxidative capacity and fasting-induced metabolic regulation in human adipose tissue...
November 30, 2017: Journal of Applied Physiology
https://www.readbyqxmd.com/read/29180230/glucocorticoids-genes-and-brain-function
#3
REVIEW
Grzegorz R Juszczak, Adrian M Stankiewicz
The identification of key genes in transcriptomic data constitutes a huge challenge. Our review of microarray reports revealed 88 genes whose transcription is consistently regulated by glucocorticoids (GCs), such as cortisol, corticosterone and dexamethasone, in the brain. Replicable transcriptomic data were combined with biochemical and physiological data to create an integrated view of the effects induced by GCs. The most frequently reported genes were Errfi1 and Ddit4. Their up-regulation was associated with the altered transcription of genes regulating growth factor and mTORC1 signaling (Gab1, Tsc22d3, Dusp1, Ndrg2, Ppp5c and Sesn1) and progression of the cell cycle (Ccnd1, Cdkn1a and Cables1)...
November 24, 2017: Progress in Neuro-psychopharmacology & Biological Psychiatry
https://www.readbyqxmd.com/read/29170599/complexity-and-challenges-in-noncontact-high-temperature-measurements-in-microwave-assisted-catalytic-reactors
#4
Lalit S Gangurde, Guido S J Sturm, Tushar J Devadiga, Andrzej I Stankiewicz, Georgios D Stefanidis
The complexity and challenges in noncontact temperature measurements inside microwave-heated catalytic reactors are presented in this paper. A custom-designed microwave cavity has been used to focus the microwave field on the catalyst and enable monitoring of the temperature field in 2D. A methodology to study the temperature distribution in the catalytic bed by using a thermal camera in combination with a thermocouple for a heterogeneous catalytic reaction (methane dry reforming) under microwave heating has been demonstrated...
November 15, 2017: Industrial & Engineering Chemistry Research
https://www.readbyqxmd.com/read/29125681/2015-16-i-move-i-move-multicentre-case-control-study-in-europe-moderate-vaccine-effectiveness-estimates-against-influenza-a-h1n1-pdm09-and-low-estimates-against-lineage-mismatched-influenza-b-among-children
#5
Esther Kissling, Marta Valenciano, Francisco Pozo, Ana-Maria Vilcu, Annicka Reuss, Caterina Rizzo, Amparo Larrauri, Judit Krisztina Horváth, Mia Brytting, Lisa Domegan, Monika Korczyńska, Adam Meijer, Ausenda Machado, Alina Ivanciuc, Vesna Višekruna Vučina, Sylvie van der Werf, Brunhilde Schweiger, Antonino Bella, Alin Gherasim, Annamária Ferenczi, Katherina Zakikhany, Joan O Donnell, Iwona Paradowska-Stankiewicz, Frederika Dijkstra, Raquel Guiomar, Mihaela Lazar, Sanja Kurečić Filipović, Kari Johansen, Alain Moren
BACKGROUND: During the 2015/16 influenza season in Europe, the co-circulating influenza viruses were A(H1N1)pdm09 and B/Victoria, which was antigenically distinct from the B/Yamagata component in the trivalent influenza vaccine. METHODS: We used the test negative design in a multicentre case-control study in twelve European countries to measure 2015/16 influenza vaccine effectiveness (VE) against medically-attended influenza-like illness (ILI) laboratory-confirmed as influenza...
November 10, 2017: Influenza and Other Respiratory Viruses
https://www.readbyqxmd.com/read/29075976/specific-plasma-amino-acid-disturbances-associated-with-metabolic-syndrome
#6
Marta Siomkajło, Jacek Rybka, Magdalena Mierzchała-Pasierb, Andrzej Gamian, Joanna Stankiewicz-Olczyk, Marek Bolanowski, Jacek Daroszewski
PURPOSE: The primary objective of the present study was to examine the association between branched chain and aromatic amino acid profiles (BCAA and AAA respectively) and the metabolic syndrome (MS), and to evaluate the clinical utility of these associations in the diagnostic process. METHODS: Two hundred and sixty three healthy men with MS [MS(+): n = 165] and without MS [MS(-): n = 98] were enrolled in the observational study. Anthropometrical, biochemical, and amino acid measurements were performed...
October 26, 2017: Endocrine
https://www.readbyqxmd.com/read/29072584/impaired-sleep-circadian-rhythms-and-neurogenesis-in-diet-induced-premature-aging
#7
Alexander J Stankiewicz, Erin M McGowan, Lili Yu, Irina V Zhdanova
Chronic high caloric intake (HCI) is a risk factor for multiple major human disorders, from diabetes to neurodegeneration. Mounting evidence suggests a significant contribution of circadian misalignment and sleep alterations to this phenomenon. An inverse temporal relationship between sleep, activity, food intake, and clock mechanisms in nocturnal and diurnal animals suggests that a search for effective therapeutic approaches can benefit from the use of diurnal animal models. Here, we show that, similar to normal aging, HCI leads to the reduction in daily amplitude of expression for core clock genes, a decline in sleep duration, an increase in scoliosis, and anxiety-like behavior...
October 26, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29059667/-life-saving-cricothyroidotomy-in-throat-and-laryngeal-injuries-case-study
#8
Maja Chrzanowska-Wąsik, Leszek Sobiech, Vadim Matsibora, Tomasz Stankiewicz, Mariusz Goniewicz, Kamil Bednarz, Patryk Rzońca
The percentage of laryngeal injuries managed by hospital emergency departments is low. Currently, with the Emergency Medical Services working more efficiently, diagnostic imaging tools being more available and more precise surgical procedures after the injury, the mortality and disability rate among trauma victims is systematically decreasing. The given paper presents a case of a multiple organ trauma, including trauma to the larynx and throat, experienced during agricultural works. Life-saving surgical cricothyroidotomy using a tracheal tube was performed after preliminary diagnosis of the patient...
2017: Wiadomości Lekarskie: Organ Polskiego Towarzystwa Lekarskiego
https://www.readbyqxmd.com/read/29016504/accuracy-of-four-imaging-techniques-for-diagnosis-of-posterior-pelvic-floor-disorders
#9
Isabelle M A van Gruting, Aleksandra Stankiewicz, Kirsten Kluivers, Riccardo De Bin, Helena Blake, Abdul H Sultan, Ranee Thakar
OBJECTIVE: To establish the diagnostic test accuracy of evacuation proctography, magnetic resonance imaging (MRI), transperineal ultrasonography, and endovaginal ultrasonography for detecting posterior pelvic floor disorders (rectocele, enterocele, intussusception, and anismus) in women with obstructed defecation syndrome and secondarily to identify the most patient-friendly imaging technique. METHODS: In this prospective cohort study, 131 women with symptoms of obstructed defecation syndrome underwent evacuation proctogram, MRI, and transperineal and endovaginal ultrasonography...
November 2017: Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28985207/erratum-thermoneutral-housing-exacerbates-nonalcoholic-fatty-liver-disease-in-mice-and-allows-for-sex-independent-disease-modeling
#10
Daniel A Giles, Maria E Moreno-Fernandez, Traci E Stankiewicz, Simon Graspeuntner, Monica Cappelletti, David Wu, Rajib Mukherjee, Calvin C Chan, Matthew J Lawson, Jared Klarquist, Annika Sünderhauf, Samir Softic, C Ronald Kahn, Kerstin Stemmer, Yoichiro Iwakura, Bruce J Aronow, Rebekah Karns, Kris A Steinbrecher, Christopher L Karp, Rachel Sheridan, Shiva K Shanmukhappa, Damien Reynaud, David B Haslam, Christian Sina, Jan Rupp, Simon P Hogan, Senad Divanovic
This corrects the article DOI: 10.1038/nm.4346.
October 6, 2017: Nature Medicine
https://www.readbyqxmd.com/read/28942966/haploinsufficiency-of-the-chromatin-remodeler-bptf-causes-syndromic-developmental-and-speech-delay-postnatal-microcephaly-and-dysmorphic-features
#11
Paweł Stankiewicz, Tahir N Khan, Przemyslaw Szafranski, Leah Slattery, Haley Streff, Francesco Vetrini, Jonathan A Bernstein, Chester W Brown, Jill A Rosenfeld, Surya Rednam, Sarah Scollon, Katie L Bergstrom, Donald W Parsons, Sharon E Plon, Marta W Vieira, Caio R D C Quaio, Wagner A R Baratela, Johanna C Acosta Guio, Ruth Armstrong, Sarju G Mehta, Patrick Rump, Rolph Pfundt, Raymond Lewandowski, Erica M Fernandes, Deepali N Shinde, Sha Tang, Juliane Hoyer, Christiane Zweier, André Reis, Carlos A Bacino, Rui Xiao, Amy M Breman, Janice L Smith, Nicholas Katsanis, Bret Bostwick, Bernt Popp, Erica E Davis, Yaping Yang
Bromodomain PHD finger transcription factor (BPTF) is the largest subunit of nucleosome remodeling factor (NURF), a member of the ISWI chromatin-remodeling complex. However, the clinical consequences of disruption of this complex remain largely uncharacterized. BPTF is required for anterior-posterior axis formation of the mouse embryo and was shown to promote posterior neuroectodermal fate by enhancing Smad2-activated wnt8 expression in zebrafish. Here, we report eight loss-of-function and two missense variants (eight de novo and two of unknown origin) in BPTF on 17q24...
October 5, 2017: American Journal of Human Genetics
https://www.readbyqxmd.com/read/28941358/rates-of-vaccination-against-streptococcus-pneumoniae-in-cochlear-implant-patients
#12
Anna Piotrowska, Iwona Paradowska-Stankiewicz, Henryk Skarżyński
BACKGROUND Streptococcus pneumoniae can cause life-threatening illness, with invasive pneumococcal diseases (IPD) like meningitis, sepsis, bacteremic pneumonia, and bacteremia being major causes of morbidity and mortality. Studies have shown that patients who have had a cochlear implant, particularly children, have an increased risk of bacterial (pneumococcal) meningitis. Vaccination in patients with cochlear implants is important and recommended universally. The World Health Organization recommends the use of pneumococcal conjugate vaccines in all countries and considers their use to be a priority in all national immunization programs...
September 23, 2017: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/28934986/identification-of-novel-candidate-disease-genes-from-de-novo-exonic-copy-number-variants
#13
Tomasz Gambin, Bo Yuan, Weimin Bi, Pengfei Liu, Jill A Rosenfeld, Zeynep Coban-Akdemir, Amber N Pursley, Sandesh C S Nagamani, Ronit Marom, Sailaja Golla, Lauren Dengle, Heather G Petrie, Reuben Matalon, Lisa Emrick, Monica B Proud, Diane Treadwell-Deering, Hsiao-Tuan Chao, Hannele Koillinen, Chester Brown, Nora Urraca, Roya Mostafavi, Saunder Bernes, Elizabeth R Roeder, Kimberly M Nugent, Patricia I Bader, Gary Bellus, Michael Cummings, Hope Northrup, Myla Ashfaq, Rachel Westman, Robert Wildin, Anita E Beck, LaDonna Immken, Lindsay Elton, Shaun Varghese, Edward Buchanan, Laurence Faivre, Mathilde Lefebvre, Christian P Schaaf, Magdalena Walkiewicz, Yaping Yang, Sung-Hae L Kang, Seema R Lalani, Carlos A Bacino, Arthur L Beaudet, Amy M Breman, Janice L Smith, Sau Wai Cheung, James R Lupski, Ankita Patel, Chad A Shaw, Paweł Stankiewicz
BACKGROUND: Exon-targeted microarrays can detect small (<1000 bp) intragenic copy number variants (CNVs), including those that affect only a single exon. This genome-wide high-sensitivity approach increases the molecular diagnosis for conditions with known disease-associated genes, enables better genotype-phenotype correlations, and facilitates variant allele detection allowing novel disease gene discovery. METHODS: We retrospectively analyzed data from 63,127 patients referred for clinical chromosomal microarray analysis (CMA) at Baylor Genetics laboratories, including 46,755 individuals tested using exon-targeted arrays, from 2007 to 2017...
September 21, 2017: Genome Medicine
https://www.readbyqxmd.com/read/28879363/bio-based-materials-general-discussion
#14
George Huber, Dimitris Argyropoulos, Avtar Matharu, Harry Bitter, Christian Stevens, Servann Herou, Karen Wilson, James Clark, Deepak Pant, Carlos I Cabrera-Rodríguez, Joseph Samec, Bruce E Dale, Thomas Farmer, Mark Mascal, Anne Horan, Andrzej Stankiewicz, Florence Gschwend, Xindong Mu, Long Zhou, Xiaoming Huang, Changwei Hu, Terence Cooper, Laura Sparlinek, Vitaliy Budarin, Eero Kontturi, Andrew Hunt, Amalio Garrido, Keith Waldron, Fang Zhang, Anna Zhenova, David Constable, Simo Sarkanen, Magdalena Titirici, Gadi Rothenberg, Jakob Albert, Duncan Macquarrie
No abstract text is available yet for this article.
September 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28879356/feedstocks-and-analysis-general-discussion
#15
Leigh Aldous, Dimitris Argyropoulos, Vitaliy Budarin, Carlos I Cabrera-Rodríguez, James Clark, Marta Coma, David Constable, Jiajun Fan, Florence Gschwend, Daniel Hayes, Changwei Hu, George Huber, Trevor Hughes, Andrew Hunt, Alexei Lapkin, Gary Lye, Mark Mascal, Avtar Matharu, Xindong Mu, Deepak Pant, Emmanouil Papaioannou, Roberto Rinaldi, Gadi Rothenberg, Joseph Samec, Simo Sarkanen, Andrzej Stankiewicz, Christian Stevens, Magdalena Titirici, Keith Waldron, Kirsty Wilson, Anna Zhenova, Long Zhou, Vânia Zuin
No abstract text is available yet for this article.
September 21, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28872560/use-of-hypochlorous-acid-as-a-preoperative-antiseptic-before-placement-of-dermal-fillers-an-alternative-to-the-standard-options
#16
Iona Chapman, Jeffrey T S Hsu, Kelly Stankiewicz, Ashish C Bhatia
No abstract text is available yet for this article.
August 11, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/28801776/effects-of-training-status-on-pdh-regulation-in-human-skeletal-muscle-during-exercise
#17
Anders Gudiksen, Lærke Bertholdt, Tomasz Stankiewicz, Jonas Tybirk, Peter Plomgaard, Jens Bangsbo, Henriette Pilegaard
Pyruvate dehydrogenase (PDH) is the gateway enzyme for carbohydrate-derived pyruvate feeding into the TCA cycle. PDH may play a central role in regulating substrate shifts during exercise, but the influence of training state on PDH regulation during exercise is not fully elucidated. The purpose of this study was to investigate the impact of training state on post-translational regulation of PDHa activity during submaximal and exhaustive exercise. Eight untrained and nine endurance exercise-trained healthy male subjects performed incremental exercise on a cycle ergometer: 40 min at 50% incremental peak power output (IPPO), 10 min at 65% (IPPO), followed by 80% (IPPO) until exhaustion...
December 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/28797322/2015-16-seasonal-vaccine-effectiveness-against-hospitalisation-with-influenza-a-h1n1-pdm09-and-b-among-elderly-people-in-europe-results-from-the-i-move-project
#18
Marc Rondy, Amparo Larrauri, Itziar Casado, Valeria Alfonsi, Daniela Pitigoi, Odile Launay, Ritva K Syrjänen, Giedre Gefenaite, Ausenda Machado, Vesna Višekruna Vučina, Judith Krisztina Horváth, Iwona Paradowska-Stankiewicz, Sierk D Marbus, Alin Gherasim, Jorge Alberto Díaz-González, Caterina Rizzo, Alina E Ivanciuc, Florence Galtier, Niina Ikonen, Aukse Mickiene, Veronica Gomez, Sanja Kurečić Filipović, Annamária Ferenczi, Monika R Korcinska, Rianne van Gageldonk-Lafeber, Marta Valenciano
We conducted a multicentre test-negative case-control study in 27 hospitals of 11 European countries to measure 2015/16 influenza vaccine effectiveness (IVE) against hospitalised influenza A(H1N1)pdm09 and B among people aged ≥ 65 years. Patients swabbed within 7 days after onset of symptoms compatible with severe acute respiratory infection were included. Information on demographics, vaccination and underlying conditions was collected. Using logistic regression, we measured IVE adjusted for potential confounders...
July 27, 2017: Euro Surveillance: Bulletin Européen sur les Maladies Transmissibles, European Communicable Disease Bulletin
https://www.readbyqxmd.com/read/28780236/tenecteplase-versus-alteplase-for-management-of-acute-ischaemic-stroke-nor-test-a-phase-3-randomised-open-label-blinded-endpoint-trial
#19
RANDOMIZED CONTROLLED TRIAL
Nicola Logallo, Vojtech Novotny, Jörg Assmus, Christopher E Kvistad, Lars Alteheld, Ole Morten Rønning, Bente Thommessen, Karl-Friedrich Amthor, Hege Ihle-Hansen, Martin Kurz, Håkon Tobro, Kamaljit Kaur, Magdalena Stankiewicz, Maria Carlsson, Åse Morsund, Titto Idicula, Anne Hege Aamodt, Christian Lund, Halvor Næss, Ulrike Waje-Andreassen, Lars Thomassen
BACKGROUND: Tenecteplase is a newer thrombolytic agent with some pharmacological advantages over alteplase. Previous phase 2 trials of tenecteplase in acute ischaemic stroke have shown promising results. We aimed to investigate the safety and efficacy of tenecteplase versus alteplase in patients with acute stroke who were eligible for intravenous thrombolysis. METHODS: This phase 3, randomised, open-label, blinded endpoint, superiority trial was done in 13 stroke units in Norway...
October 2017: Lancet Neurology
https://www.readbyqxmd.com/read/28762179/vaginal-laxity-what-does-this-symptom-mean
#20
Hans Peter Dietz, Martyna Stankiewicz, Ixora Kamisan Atan, Caroline Wanderley Ferreira, Maciej Socha
INTRODUCTION AND HYPOTHESIS: Vaginal laxity is a poorly understood symptom of pelvic floor dysfunction. The purpose of this study was to investigate associations between the symptom of vaginal laxity and its bother on the one hand, and demographic data, other symptoms, and findings on examination on the other hand. METHODS: This was a retrospective observational study at a tertiary urogynecological unit. A total of 337 patients were seen for a standardized interview, clinical examination (ICS POP-Q) and 4D translabial ultrasonography...
July 31, 2017: International Urogynecology Journal
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