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https://www.readbyqxmd.com/read/27923185/profiling-perpetrators-of-interpersonal-violence-against-children-in-sport-based-on-a-victim-survey
#1
Tine Vertommen, Jarl Kampen, Nicolette Schipper-van Veldhoven, Kristien Wouters, Kasia Uzieblo, Filip Van Den Eede
The current article reports on perpetrator characteristics gathered in the first large-scale prevalence study on interpersonal violence against children in sport in the Netherlands and Belgium. Using retrospective web survey design, 4043 adults answered questions on their experiences in youth sport. The study looks at the number of perpetrators as well as individual descriptive characteristics (sex, age, and role in the sport organization) of perpetrators of psychological, physical and sexual violence as reported retrospectively by victim-respondents...
December 3, 2016: Child Abuse & Neglect
https://www.readbyqxmd.com/read/27900176/systematic-review-of-physical-activity-and-exercise-interventions-to-improve-health-fitness-and-well-being-of-children-and-young-people-who-use-wheelchairs
#2
Thomas D O'Brien, Jane Noyes, Llinos Haf Spencer, Hans-Peter Kubis, Richard P Hastings, Rhiannon Whitaker
AIM: To perform a systematic review establishing the current evidence base for physical activity and exercise interventions that promote health, fitness and well-being, rather than specific functional improvements, for children who use wheelchairs. DESIGN: A systematic review using a mixed methods design. DATA SOURCES: A wide range of databases, including Web of Science, PubMed, BMJ Best Practice, NHS EED, CINAHL, AMED, NICAN, PsychINFO, were searched for quantitative, qualitative and health economics evidence...
2016: BMJ Open Sport & Exercise Medicine
https://www.readbyqxmd.com/read/27868325/novel-eed-mutation-in-patient-with-weaver-syndrome
#3
Erin Cooney, Weimin Bi, Alan E Schlesinger, Sherry Vinson, Lorraine Potocki
Weaver syndrome is a rare condition characterized by overgrowth, macrocephaly, accelerated osseous maturation, variable intellectual disability, and characteristic facial features. Pathogenic variants in EZH2, a histone methyltransferase, have previously been identified as a cause of Weaver syndrome. However, the underlying molecular cause in many patients remains unknown. We report a patient with a clinical diagnosis of Weaver syndrome whose exome was initially non-diagnostic. Reports in the medical literature of EED associated overgrowth prompted re-analysis of the patient's original exome data...
November 21, 2016: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/27848898/proteomic-analysis-of-endothelin-1-targets-in-the-regulation-of-cardiomyocyte-proliferation
#4
Alexandra N Shin, Chiranjib Dasgupta, Lubo Zhang, Guangyu Zhang, Kala Seal
Hypoxia is a fetal stressor that leads to the production of endothelin-1 (ET-1). Previous work has shown that ET-1 treatment leads to the premature terminal differentiation of fetal cardiomyocytes. However, the precise mechanism is unknown. We tested the hypothesis that the fetal cardiomyocyte proteome will be greatly altered due to ET-1-treatment, which reveals a potential molecular mechanism of ET-1-induced terminal differentiation. Over a thousand proteins were detected in the fetal cardiomyocytes and among them 75 proteins were significantly altered due to ET-1 treatment...
November 16, 2016: Current Topics in Medicinal Chemistry
https://www.readbyqxmd.com/read/27846361/early-elective-delivery-and-vaginal-birth-after-cesarean-in-rural-us-maternity-hospitals
#5
Demetra Heinrich, Rachel I Vogel, Katy B Kozhimannil
INTRODUCTION: The purpose of this study was to describe policies on early elective delivery (EED) and vaginal birth after cesarean (VBAC) in rural US maternity hospitals and to measure whether hospital policies differ by staffing, facilities, or birth volume. METHODS: Data came from a telephone survey, conducted among all rural maternity hospitals in nine US states from November 2013 to March 2014, to report on EED and VBAC at the hospital level. The associations between EED and VBAC and hospital characteristics were analyzed using χ2 and Fisher's exact tests...
October 2016: Rural and Remote Health
https://www.readbyqxmd.com/read/27845897/the-jazf1-suz12-fusion-protein-disrupts-prc2-complexes-and-impairs-chromatin-repression-during-human-endometrial-stromal-tumorogenesis
#6
Xianyong Ma, Jinglan Wang, Jianhui Wang, Charles X Ma, Xiaobin Gao, Vytas Patriub, Jeffrey L Sklar
The Polycomb repressive complex 2 (PRC2), which contains three core proteins EZH2, EED and SUZ12, controls chromatin compaction and transcription repression through trimethylation of lysine 27 on histone 3. The (7;17)(p15;q21) chromosomal translocation present in most cases of endometrial stromal sarcomas (ESSs) results in the in-frame fusion of the JAZF1 and SUZ12 genes. We have investigated whether and how the fusion protein JAZF1-SUZ12 functionally alters PRC2. We found that the fusion protein exists at high levels in ESS containing the t(7;17)...
November 10, 2016: Oncotarget
https://www.readbyqxmd.com/read/27816303/ventricular-function-and-ventriculo-arterial-coupling-after-palliation-of-hypoplastic-left-heart-syndrome-a-comparative-study-with-fontan-patients-with-lv-morphology
#7
J Logoteta, C Ruppel, J H Hansen, G Fischer, K Becker, H-H Kramer, A Uebing
BACKGROUND: Conceptually the right ventricle (RV) is less suitable to support the Fontan circulation than the left (LV). After palliation of hypoplastic left heart syndrome (HLHS) involving aortic reconstruction during the Norwood procedure the RV is exposed to abnormal afterload. We studied ventricular function and ventriculo-arterial coupling in HLHS patients (RV) and Fontan patients with single LV morphology that did (LV+N) and did not (LV-N) undergo Norwood-type aortic reconstruction...
October 29, 2016: International Journal of Cardiology
https://www.readbyqxmd.com/read/27810313/the-economic-promise-of-developing-and-implementing-dengue-vaccines-evidence-from-a-systematic-review
#8
REVIEW
Iara C Endo, Patricia K Ziegelmann, Anita Patel
BACKGROUND: Dengue fever is one of the most rapidly advancing viral vector-borne diseases worldwide and vaccine candidates are in the final stages of clinical trials, representing a decisive opportunity to control the disease. To decide whether and where to support the introduction of new vaccines it is crucial to assess costs imposed by the disease and cost-effectiveness of vaccine programmes. OBJECTIVE: To identify economic evidence about dengue fever immunization, by systematic review, to assist future policy decisions and investment...
December 7, 2016: Vaccine
https://www.readbyqxmd.com/read/27807040/a-combined-intervention-of-zinc-multiple-micronutrients-and-albendazole-does-not-ameliorate-environmental-enteric-dysfunction-or-stunting-in-rural-malawian-children-in-a-double-blind-randomized-controlled-trial
#9
Alfred Z Wang, Robert J Shulman, Audrey H Crocker, Chrissie Thakwalakwa, Kenneth M Maleta, Sridevi Devaraj, Mark J Manary, Indi Trehan
BACKGROUND: Environmental enteric dysfunction (EED) and linear growth stunting affect many rural agrarian children in the developing world and contribute to the persistently high rates of stunting that are observed worldwide. Effective interventions to consistently ameliorate EED are lacking. OBJECTIVE: We tested whether a bundle of safe and affordable interventions would decrease EED and stunting over 12-24 wk in a cohort of rural Malawian children 12-35 mo old...
November 2, 2016: Journal of Nutrition
https://www.readbyqxmd.com/read/27798797/many-miles-to-go-a-systematic-review-of-the-state-of-cost-utility-analyses-in-brazil
#10
REVIEW
Alessandro G Campolina, Luciana M Rozman, Tassia C Decimoni, Roseli Leandro, Hillegonda M D Novaes, Patrícia Coelho De Soárez
BACKGROUND: Little is known about the quality and quantity of cost-utility analyses (CUAs) in Brazil. OBJECTIVE: The objective of this study was to provide a systematic review of published CUAs of healthcare technologies in Brazil. METHODS: We performed a systematic review of economic evaluations studies published in MEDLINE, EMBASE, LILACS (Latin American and Caribbean Health Sciences Literature), SciELO (Scientific Electronic Library Online), NHS EED (National Health Service Economic Evaluation Database), HTA (Health Technology Assessment) Database, Web of Science, Scopus, Bireme (Biblioteca Regional de Medicina), BVS ECOS (Health Economics database of the Brazilian Virtual Library of Health), and SISREBRATS (Sistema de Informação da Rede Brasileira de Avaliação de Tecnologias em Saúde [Brazilian Network for the Evaluation of Health Technologies]) from 1980 to 2013...
October 31, 2016: Applied Health Economics and Health Policy
https://www.readbyqxmd.com/read/27785772/a-systematic-review-of-cardiovascular-outcomes-based-cost-effectiveness-analyses-of-lipid-lowering-therapies
#11
REVIEW
Ching-Yun Wei, Ruben G W Quek, Guillermo Villa, Shravanthi R Gandra, Carol A Forbes, Steve Ryder, Nigel Armstrong, Sohan Deshpande, Steven Duffy, Jos Kleijnen, Peter Lindgren
BACKGROUND: Previous reviews have evaluated economic analyses of lipid-lowering therapies using lipid levels as surrogate markers for cardiovascular disease. However, drug approval and health technology assessment agencies have stressed that surrogates should only be used in the absence of clinical endpoints. OBJECTIVE: The aim of this systematic review was to identify and summarise the methodologies, weaknesses and strengths of economic models based on atherosclerotic cardiovascular disease event rates...
October 27, 2016: PharmacoEconomics
https://www.readbyqxmd.com/read/27783956/highly-efficient-genome-editing-of-murine-and-human-hematopoietic-progenitor-cells-by-crispr-cas9
#12
Michael C Gundry, Lorenzo Brunetti, Angelique Lin, Allison E Mayle, Ayumi Kitano, Dimitrios Wagner, Joanne I Hsu, Kevin A Hoegenauer, Cliona M Rooney, Margaret A Goodell, Daisuke Nakada
Our understanding of the mechanisms that regulate hematopoietic stem/progenitor cells (HSPCs) has been advanced by the ability to genetically manipulate mice; however, germline modification is time consuming and expensive. Here, we describe fast, efficient, and cost-effective methods to directly modify the genomes of mouse and human HSPCs using the CRISPR/Cas9 system. Using plasmid and virus-free delivery of guide RNAs alone into Cas9-expressing HSPCs or Cas9-guide RNA ribonucleoprotein (RNP) complexes into wild-type cells, we have achieved extremely efficient gene disruption in primary HSPCs from mouse (>60%) and human (∼75%)...
October 25, 2016: Cell Reports
https://www.readbyqxmd.com/read/27779289/-cost-effectiveness-of-psychotherapy-for-personality-disorders-a-systematic-review-on-economic-evaluation-studies
#13
P Wetzelaer, J Lokkerbol, A Arntz, A van Asselt, S Evers
So far, there has not been a complete overview of the cost-effectiveness of psychotherapy for patients with a personality disorder.<br/> AIM: To provide an overview of scientific literature on the cost-effectiveness of psychotherapy for patients with a personality disorder.<br/> METHOD: We reviewed the literature systematically, searching the NHS EED, PubMed and PsycINFO databases. We concentrated solely on full economic evaluations of treatments in which all patients had a personality disorder...
2016: Tijdschrift Voor Psychiatrie
https://www.readbyqxmd.com/read/27766855/does-biotransformation-of-aryl-phosphate-flame-retardants-in-blood-cast-a-new-perspective-on-their-debated-biomarkers
#14
Nele Van den Eede, Ana Ballesteros-Gómez, Hugo Neels, Adrian Covaci
Aryl phosphate flame retardants (aryl-PFRs), such as triphenyl phosphate (TPHP) and 2-ethylhexyl diphenyl phosphate (EHDPHP), are emerging contaminants that can exhibit toxic properties, including severe aquatic toxicity and endocrine disruptive effects. Monitoring exposure to aryl-PFRs through specific biomarkers is necessary to assess the health risk associated with chronic exposure. Hydrolytic serum enzymes could play an important role in the formation of the hydrolysis product diphenyl phosphate (DPHP), the seemingly most abundant in vivo biomarker of TPHP in urine...
November 4, 2016: Environmental Science & Technology
https://www.readbyqxmd.com/read/27717745/environmental-estrogen-like-endocrine-disrupting-chemicals-and-breast-cancer
#15
Marisa Morgan, Alok Deoraj, Quentin Felty, Deodutta Roy
BACKGROUND: Estrogen-mimicking endocrine disruptors (EEDs) such as polychlorinated biphenyls (PCBs), bisphenol A (BPA), and phthalates have been found ubiquitously throughout our environment. Although exposure to EEDs has the ability to interfere with endocrine control of reproductive function and development in both humans and wildlife, inconsistent reports have made it difficult to draw conclusions concerning the hypothesized increased risk of breast cancer associated with EEDs. OBJECTIVES: The purpose of this study was to examine the cross-sectional relationship between exposure to PCBs, BPA or phthalates; and risk of breast cancer in U...
October 4, 2016: Molecular and Cellular Endocrinology
https://www.readbyqxmd.com/read/27716267/economic-evaluation-of-treatments-for-patients-with-localized-prostate-cancer-in-europe-a-systematic-review
#16
Virginia Becerra, Mónica Ávila, Jorge Jimenez, Laura Cortes-Sanabria, Yolanda Pardo, Olatz Garin, Angels Pont, Jordi Alonso, Francesc Cots, Montse Ferrer
BACKGROUND: Our objective was to assess the efficiency of treatments in patients with localized prostate cancer, by synthesizing available evidence from European economic evaluations through systematic review. METHODS: Articles published 2000-2015 were searched in MEDLINE, EMBASE and NHS EED (Prospero protocol CRD42015022063). Two authors independently selected studies for inclusion and extracted the data. A third reviewer resolved discrepancies. We included European economic evaluations or cost comparison studies, of any modality of surgery or radiotherapy treatments, regardless the comparator/s...
October 3, 2016: BMC Health Services Research
https://www.readbyqxmd.com/read/27702555/what-adherence-measures-should-be-used-in-trials-of-home-based-rehabilitation-interventions-a-systematic-review-of-the-validity-reliability-and-acceptability-of-measures
#17
REVIEW
Rachael Frost, Sara Levati, Doreen McClurg, Marian Brady, Brian Williams
OBJECTIVE: To systematically review methods for measuring adherence used in home-based rehabilitation trials, and evaluate their validity, reliability and acceptability. DATA SOURCES: Phase 1: We searched CENTRAL, EED and HTA (Jan 2000-April 2013) to identify adherence measures used in randomised controlled trials of allied health professional home-based rehabilitation interventions. Phase 2: We searched Medline, Embase, CINAHL, AMED, PsycINFO, CENTRAL, ProQuest and Web of Science (inception-April 2015) for measurement property assessments (MPAs) for each measure...
October 1, 2016: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/27680425/evaluating-the-costs-and-benefits-of-pneumococcal-vaccination-in-adults
#18
Barbara Rita Porchia, Paolo Bonanni, Angela Bechini, Gugliemo Bonaccorsi, Sara Boccalini
Pneumococcal infection is a public health concern that disproportionately affects the young, the elderly, and the immunocompromised. There is an open debate on the implementation of polysaccharide and/or conjugate vaccines for pneumococcal diseases in adults and the elderly in many countries. The aim of this paper is to systematically review the economic profile of pneumococcal vaccines in adults in terms of costs and benefits. Areas covered: The search for economic studies on pneumococcal vaccination was carried out in Pubmed, Embase, Scopus, and the HTA and NHS EED databases and through a manual search in journals dealing with economic evaluations...
October 12, 2016: Expert Review of Vaccines
https://www.readbyqxmd.com/read/27634302/dynamic-protein-interactions-of-the-polycomb-repressive-complex-2-during-differentiation-of-pluripotent-cells
#19
Giorgio Oliviero, Gerard L Brien, Ariane Waston, Gundula Streubel, Emilia Jerman, Darrell Andrews, Benjamin Doyle, Nayla Munawar, Kieran Wynne, John Crean, Adrian P Bracken, Gerard Cagney
Polycomb proteins assemble to form complexes with important roles in epigenetic regulation. The Polycomb Repressive Complex 2 (PRC2) modulates the di- and tri-methylation of lysine 27 on histone H3, each of which are associated with gene repression. Although three subunits, EZH1/2, SUZ12, and EED, form the catalytic core of PRC2, a wider group of proteins associate with low stoichiometry. This raises the question of whether dynamic variation of the PRC2 interactome results in alternative forms of the complex during differentiation...
November 2016: Molecular & Cellular Proteomics: MCP
https://www.readbyqxmd.com/read/27632432/stable-isotope-techniques-for-the-assessment-of-host-and-microbiota-response-during-gastrointestinal-dysfunction
#20
Ross N Butler, Margaret Kosek, Nancy F Krebs, Cornelia U Loechl, Alexander Loy, Victor O Owino, Michael B Zimmermann, Douglas J Morrison
The International Atomic Energy Agency convened a technical meeting on environmental enteric dysfunction (EED) in Vienna (28-30 October 2015; https://nucleus.iaea.org/HHW/Nutrition/EED_Technical_Meeting/index.html) to bring together international experts in the fields of EED, nutrition and stable isotope technologies. Advances in stable isotope labelling techniques open up new possibilities to improve our understanding of gastrointestinal dysfunction and the role of the microbiota in host health. In the context of EED, little is known about the role gut dysfunction may play in macro- and micronutrient bioavailability and requirements and what the consequences may be for nutritional status and linear growth...
September 14, 2016: Journal of Pediatric Gastroenterology and Nutrition
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