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https://www.readbyqxmd.com/read/29025841/neighbourhood-characteristics-and-mental-disorders-in-three-chinese-cities-multilevel-models-from-the-world-mental-health-surveys
#1
Alexandre Dias Porto Chiavegatto Filho, Laura Sampson, Silvia S Martins, Shui Yu, Yueqin Huang, Yanling He, Sing Lee, Chiyi Hu, Alan Zaslavsky, Ronald C Kessler, Sandro Galea
OBJECTIVES: The rapid growth of urban areas in China in the past few decades has introduced profound changes in family structure and income distribution that could plausibly affect mental health. Although multilevel studies of the influence of area-level socioeconomic factors on mental health have become more common in other parts of the world, a study of this sort has not been carried out in Chinese cities. Our objectives were to examine the associations of two key neighbourhood-level variables-median income and percentage of married individuals living in the neighbourhood-with mental disorders net of individual-level income and marital status in three Chinese cities...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28988385/adapting-current-model-with-field-data-of-related-performance-reference-compounds-in-passive-samplers-to-accurately-monitor-hydrophobic-organic-compounds-in-aqueous-media
#2
Pokem Temoka, Gerd Pfister, Bernhard Henkelmann, Karl-Werner Schramm
Performance reference compounds (PRCs) are neutral organic compounds, introduced in a passive sampler prior deployment for the assessment of in situ sampling rate. In this study, evaluation of in situ sampling rates of 16 (13)C-PAH-PRCs with moderate and high hydrophobicity was established to provide an overall correction factor for variations in virtual organism (VO) uptake rates of the analytes of interest. In situ sampling rate was compared to an empirical model during sampling campaign in 2011 with VO in 12 different sites along the Three Gorges Reservoir (TGR) in China...
October 7, 2017: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/28984200/incorporating-genomic-transcriptomic-and-clinical-data-a-prognostic-and-stem-cell-like-myc-and-prc-imbalance-in-high-risk-neuroblastoma
#3
Xinan Holly Yang, Fangming Tang, Jisu Shin, John M Cunningham
BACKGROUND: Previous studies suggested that cancer cells possess traits reminiscent of the biological mechanisms ascribed to normal embryonic stem cells (ESCs) regulated by MYC and Polycomb repressive complex 2 (PRC2). Several poorly differentiated adult tumors showed preferentially high expression levels in targets of MYC, coincident with low expression levels in targets of PRC2. This paper will reveal this ESC-like cancer signature in high-risk neuroblastoma (HR-NB), the most common extracranial solid tumor in children...
October 3, 2017: BMC Systems Biology
https://www.readbyqxmd.com/read/28983509/multicellularity-enriches-the-entrainment-of-arabidopsis-circadian-clock
#4
Kosaku Masuda, Ryota Kitaoka, Kazuya Ukai, Isao T Tokuda, Hirokazu Fukuda
The phase response curve (PRC) of the circadian clock provides one of the most significant indices for anticipating entrainment of outer cycles, despite the difficulty of making precise PRC determinations in experiments. We characterized the PRC of the Arabidopsisthaliana circadian clock on the basis of its phase-locking property to variable periodic pulse perturbations. Experiments revealed that the PRC changed remarkably from continuous to discontinuous fashion, depending on the oscillation amplitude. Our hypothesis of amplitude-dependent adaptability to outer cycles was successfully clarified by elucidation of this transition of PRC as a change in the collective response of the circadian oscillator network...
October 2017: Science Advances
https://www.readbyqxmd.com/read/28978033/mysm1-2a-dub-is-an-epigenetic-regulator-in-human-melanoma-and-contributes-to-tumor-cell-growth
#5
Christina Wilms, Carsten M Kroeger, Adelheid V Hainzl, Ishani Banik, Clara Bruno, Ioanna Krikki, Vida Farsam, Meinhard Wlaschek, Martina V Gatzka
Histone modifying enzymes, such as histone deacetylases (HDACs) and polycomb repressive complex (PRC) components, have been implicated in regulating tumor growth, epithelial-mesenchymal transition, tumor stem cell maintenance, or repression of tumor suppressor genes - and may be promising targets for combination therapies of melanoma and other cancers. According to recent findings, the histone H2A deubiquitinase 2A-DUB/Mysm1 interacts with the p53-axis in hematopoiesis and tissue differentiation in mice, in part by modulating DNA-damage responses in stem cell and progenitor compartments...
September 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28971283/non-phytate-phosphorus-requirement-for-broilers-from-8-to-21%C3%A2-days-of-age-under-heat-stress-conditions
#6
Evandro Ferreira Cardoso, Juarez Lopes Donzele, Rita Flávia Miranda de Oliveira Donzele, Bruna Leite Sufiate, Amanda Dione Silva, Tarciso Tizziani
Two trials were conducted to determine the non-phytate phosphorus (nPP) requirement for broiler under heat stress. In both trials, birds were distributed in a completely randomized 4 × 2 factorial design with four nPP concentrations: 0.25, 0.35, 0.45, and 0.55%, and two Ca supply techniques: Ca fixed at 0.899% (CaF) or varying along with nPP aiming a 2:1 Ca to nPP ratio (CaV). Both trials had eight pens/treatment, with nine and five birds/pen for exp. 1 and exp. 2, respectively. nPP concentration had no effect on feed intake (FI), body weight gain (BWG), feed conversion ratio (FCR), nor fat deposition ratio (FDR)...
October 3, 2017: Tropical Animal Health and Production
https://www.readbyqxmd.com/read/28970702/generic-direct-acting-antivirals-in-treatment-of-chronic-hepatitis-c-infection-in-patients-of-thalassemia-major
#7
Aabha Nagral, Smita Sawant, Nishtha Nagral, Pathik Parikh, Priya Malde, Rashid Merchant
BACKGROUND: There is no published data of treating hepatitis C in thalassemia major patients with any sofosbuvir based direct acting antivirals (DAAs). This study was performed to determine the efficacy and safety of these regimes using generic drugs in the thalassemia major population. METHODS: In this observational study, 902 patients of thalassemia major from five transfusion centres in Mumbai were screened for HCV antibody. Of the 120 positive patients, HCV RNA was detected in 50%...
September 2017: Journal of Clinical and Experimental Hepatology
https://www.readbyqxmd.com/read/28966591/age-related-changes-in-perirhinal-cortex-sensitivity-to-configuration-and-part-familiarity-and-connectivity-to-visual-cortex
#8
Laura Cacciamani, Erica Wager, Mary A Peterson, Paige E Scalf
The perirhinal cortex (PRC) is a medial temporal lobe (MTL) structure known to be involved in assessing whether an object is familiar (i.e., meaningful) or novel. Recent evidence shows that the PRC is sensitive to the familiarity of both whole object configurations and their parts, and suggests the PRC may modulate part familiarity responses in V2. Here, using functional magnetic resonance imaging (fMRI), we investigated age-related decline in the PRC's sensitivity to part/configuration familiarity and assessed its functional connectivity to visual cortex in young and older adults...
2017: Frontiers in Aging Neuroscience
https://www.readbyqxmd.com/read/28966320/association-of-dyslipidemia-and-sex-with-coronary-artery-calcium-assessed-by-coronary-computed-tomography-angiography
#9
Masahiko Asami, Kyohei Yamaji, Jiro Aoki, Shuzou Tanimoto, Mika Watanabe, Yu Horiuchi, Koichi Furui, Nahoko Kato, Kazuhiro Hara, Kengo Tanabe
Previous studies reporting that statin increases coronary artery calcium (CAC) were conducted exclusively on patients with statin as a prevention, regardless of the presence or absence of dyslipidemia. The impact of sex on CAC has not been fully evaluated. We aimed to determine the association of dyslipidemia and sex with CAC using 320-row multi-detector computed tomography (MDCT).Of the 356 consecutive patients who underwent coronary MDCT, 251 patients were enrolled, after excluding those with prior stenting and/or coronary bypass grafting or images showing motion artifacts...
September 30, 2017: International Heart Journal
https://www.readbyqxmd.com/read/28950779/hb-h-disease-caused-by-multiple-mutations-in-the-polyadenylation-signal-site-and-sea-%C3%AE-%C3%AE
#10
Qiang Zhang, Xin Fan, Mingli Xu, Yijia Zhang, Huiling Xu, Xiaojun Wen, Wanjun Zhou
Thalassemia is the most common monogenic disease, with the highest incidence in Guangxi Zhuang Autonomous Region, People's Republic of China (PRC). The blood test result was not consistent with α-globin gene testing in one of the patients during daily screening. It was confirmed that there were multiple mutations at the α2-globin gene polyadenylation (polyA) signal site: HBA2: c.*64(T>C), HBA2: c.*68(A>C), HBA2: c.*71(G>A), HBA2: c.*74(C>A), HBA2: c.*82(G>A), HBA2: c.*92(A>G) and HBA2: c...
May 2017: Hemoglobin
https://www.readbyqxmd.com/read/28917011/prevalence-predictors-and-prognostic-implications-of-pr-interval-prolongation-in-patients-with-heart-failure
#11
Theodora Nikolaidou, Pierpaolo Pellicori, Jufen Zhang, Syed Kazmi, Kevin M Goode, John G Cleland, Andrew L Clark
AIMS: To determine the prevalence, incidence, predictors, and prognostic implications of PR interval prolongation in patients referred with suspected heart failure. METHODS AND RESULTS: Consecutive patients referred with suspected heart failure were prospectively enrolled. After excluding patients with implantable cardiac devices and atrial fibrillation, 1420 patients with heart failure and reduced ejection fraction (HeFREF) [age: median 71 (interquartile range IQR 63-78) years; men: 71%; NT-ProBNP: 1319 (583-3378) ng/L], 1094 with heart failure and normal ejection fraction (HeFNEF) [age: 76 (70-82) years; men: 47%; NT-ProBNP: 547 (321-1171) ng/L], and 1150 without heart failure [age: 68 (60-75) years; men: 51%; NT-ProBNP: 86 (46-140) ng/L] were included...
September 15, 2017: Clinical Research in Cardiology: Official Journal of the German Cardiac Society
https://www.readbyqxmd.com/read/28915557/loss-of-p16-ink4a-stimulates-aberrant-mitochondrial-biogenesis-through-a-cdk4-rb-independent-pathway
#12
Ethika Tyagi, Bin Liu, Chelsea Li, Tong Liu, Jared Rutter, Douglas Grossman
The tumor suppressor p16INK4A (p16) inhibits cell cycle progression through the CDK4/Rb pathway. We have previously shown that p16 regulates cellular oxidative stress, independent of its role in cell cycle control. We investigated whether loss of p16 had a direct impact on the mitochondria. We found that p16-null primary mouse fibroblasts (PMFs) displayed increased mitochondrial mass and expression of mitochondrial respiratory subunit proteins compared to wild-type (WT) PMFs. These findings in p16-null PMFs were associated with increased expression of the mitochondrial biogenesis transcription factors PRC and TFAM...
August 22, 2017: Oncotarget
https://www.readbyqxmd.com/read/28911338/organisational-culture-and-trust-as-influences-over-the-implementation-of-equity-oriented-policy-in-two-south-african-case-study-hospitals
#13
Ermin Erasmus, Lucy Gilson, Veloshnee Govender, Moremi Nkosi
BACKGROUND: This paper uses the concepts of organisational culture and organisational trust to explore the implementation of equity-oriented policies - the Uniform Patient Fee Schedule (UPFS) and Patients' Rights Charter (PRC) - in two South African district hospitals. It contributes to the small literatures on organisational culture and trust in low- and middle-income country health systems, and broader work on health systems' people-centeredness and "software". METHODS: The research entailed semi-structured interviews (Hospital A n = 115, Hospital B n = 80) with provincial, regional, district and hospital managers, as well as clinical and non-clinical hospital staff, hospital board members, and patients; observations of policy implementation, organisational functioning, staff interactions and patient-provider interactions; and structured surveys operationalising the Competing Values Framework for measuring organisational culture (Hospital A n = 155, Hospital B n = 77) and Organisational Trust Inventory (Hospital A n = 185, Hospital B n = 92) for assessing staff-manager trust...
September 15, 2017: International Journal for Equity in Health
https://www.readbyqxmd.com/read/28904822/a-parental-perspective-concerning-barriers-to-care-for-neural-tube-defects-in-china
#14
Andrew Campion, Clement Lee, Nan Bao, Jorge Lazareff
BACKGROUND: The People's Republic of China (PRC) has the highest incidence of neural tube defects (NTDs) in the world. NTDs remain a significant contributor to the global burden of disease amendable to surgical care; however, no studies to date have evaluated the patients' perspective regarding perceived barriers to care. METHODS: The study was conducted at the Shanghai Children's Medical Center (SCMC) between 6/11/2014 and 7/17/2014. Surveys were administered to families presenting to the clinic of the SCMC director for Pediatric Neurosurgery...
2017: Surgical Neurology International
https://www.readbyqxmd.com/read/28901764/equilibrium-passive-sampling-of-pop-in-lipid-rich-and-lean-fish-tissue-quality-control-using-performance-reference-compounds
#15
Tatsiana P Rusina, Pernilla Carlsson, Branislav Vrana, Foppe Smedes
Passive sampling is widely used to measure levels of contaminants in various environmental matrices, including fish tissue. Equilibrium passive sampling (EPS) of persistent organic pollutants (POP) in fish tissue has been hitherto limited to application in lipid-rich tissue. We tested several exposure methods to extend EPS applicability to lean tissue. Thin-film polydimethylsiloxane (PDMS) passive samplers were exposed statically to intact fillet and fish homogenate and dynamically by rolling with cut fillet cubes...
September 13, 2017: Environmental Science & Technology
https://www.readbyqxmd.com/read/28894283/jinqijiangtang-tablets-for-pre-diabetes-a-randomized-double-blind-and-placebo-controlled-clinical-trial
#16
Hui Wang, Liping Guo, Hongcai Shang, Ming Ren, Xuemei Wang, Dehui Wang, Jianzong Chen, Shuanglei Li, Liming Chen, Yue Wang, Zhi Liu, Jingbo Zhai, Yuzhen Song, Hongbo Cao, Junhua Zhang, Chunxiang Liu, Xiao Sun, Da Huo, Wei Mu, Li Zhang, Wenke Zheng, Xiaoyan Yan, Chen Yao
This study observed the efficacy and safety of JinqiJiangtang tablets (JQJT tablets, a traditional Chinese patent medicine) for pre-diabetes. Four hundred patients with pre-diabetes at five centres were treated for 12months and followed for an additional 12months to investigate the preventative effects of JQJT tablets (Registration ID: ChiCTR-PRC-09000401). The incidence rate of diabetes mellitus was the primary endpoint. The risk of converting from pre-diabetes to diabetes was 0.58-fold less in the JQJT tablets group than in the placebo group [HR (95% CI): 0...
September 11, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28890330/a-comparative-analysis-of-resource-utilization-between-proximal-row-carpectomy-and-partial-wrist-fusion-a-population-study
#17
Paymon Rahgozar, Lin Zhong, Kevin C Chung
PURPOSE: We conducted a population-level analysis comparing proximal row carpectomy (PRC) and partial wrist arthrodesis (PWA) for treatment of chronic wrist arthritis to (1) characterize national practice patterns, (2) determine the rate of conversion to total wrist arthrodesis (TWA), and (3) calculate the associated direct cost of care. METHODS: Using the Truven MarketScan databases from 2009 to 2015, we identified patients 18 years or older with a diagnosis of wrist osteoarthritis who had a PRC or PWA and were followed for 18 months...
August 31, 2017: Journal of Hand Surgery
https://www.readbyqxmd.com/read/28871236/non-visual-photopigments-effects-of-constant-light-emitting-diode-light-exposure-on-the-inner-retina-of-wistar-rats
#18
María M Benedetto, Mario E Guido, María A Contin
The retina is part of the central nervous system specially adapted to capture light photons and transmit this information to the brain through photosensitive retinal cells involved in visual and non-visual activities. However, excessive light exposure may accelerate genetic retinal diseases or induce photoreceptor cell (PRC) death, finally leading to retinal degeneration (RD). Light pollution (LP) caused by the characteristic use of artificial light in modern day life may accelerate degenerative diseases or promote RD and circadian desynchrony...
2017: Frontiers in Neurology
https://www.readbyqxmd.com/read/28868964/poly-%C3%AF%C2%B5-caprolactone-chitosan-nanoparticles-provide-strong-adjuvant-effect-for-hepatitis-b-antigen
#19
Sandra Jesus, Edna Soares, Gerrit Borchard, Olga Borges
AIM: This work aims to investigate the adjuvant effect of poly-ϵ-caprolactone/chitosan nanoparticles (NPs) for hepatitis B surface antigen (HBsAg) and the plasmid DNA encoding HBsAg (pRC/CMV-HBs). METHODS: Both antigens were adsorbed onto preformed NPs. Vaccination studies were performed in C57BL/6 mice. Transfection efficiency was investigated in A549 cell line. RESULTS: HBsAg-adsorbed NPs generated strong anti-HBsAg IgG titers, mainly of IgG1 isotype, and induced antigen-specific IFN-γ and IL-17 secretion by spleen cells...
September 4, 2017: Nanomedicine
https://www.readbyqxmd.com/read/28866009/long-term-functional-outcomes-in-military-service-members-and-veterans-after-traumatic-brain-injury-polytrauma-inpatient-rehabilitation
#20
Max Gray, Joyce Chung, Fatima Aguila, T Gavin Williams, Jeffrey K Teraoka, Odette A Harris
OBJECTIVE: To determine the impact of the established Polytrauma/TBI infrastructure on immediate post-treatment functional gains, the long-term sustainability of any gains and participation-related community reintegration outcomes in a baseline cohort of patients eight years post-admission. DESIGN: Retrospective review and prospective repeated measures of an inception cohort. SETTING: Veterans Affairs Palo Alto, Polytrauma Rehabilitation Center (PRC) PARTICIPANTS: 44 patients consecutively admitted to the PRC inpatient rehabilitation unit during its first full Fiscal Year, 2006...
August 30, 2017: Archives of Physical Medicine and Rehabilitation
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