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https://www.readbyqxmd.com/read/29676649/asbestos-induces-epigenetic-repression-of-ras-association-domain-containing-protein-1-p16-kinase-4a-inhibitor-and-p14-alternative-reading-frame-in-normal-human-mesothelial-cells
#1
Sichuan Xi, Eden C Payabyab, David M Straughan, Emily S Reardon, Mary Zhang, Julie A Hong, R Taylor Ripley, Chuong D Hoang, David S Schrump
RATIONALE: Whereas asbestos burden has been linked to cytogenetic alterations in malignant pleural mesotheliomas, epigenetic aberrations induced by these fibers have not been fully delineated. OBJECTIVES: The objective of this study was to establish an in vitro model to characterize early epigenetic events potentially contributing to malignant pleural mesothelioma. METHODS: Normal human mesothelial cells (LP9 and LP3) were cultured with or without crocidolite asbestos fibers (1 or 2 μg/cm2 ) for up to 10 days...
April 2018: Annals of the American Thoracic Society
https://www.readbyqxmd.com/read/29670199/evolutionary-convergence-and-divergence-in-archaeal-chromosomal-proteins-and-chromo-like-domains-from-bacteria-and-eukaryotes
#2
Gurmeet Kaur, Lakshminarayan M Iyer, Srikrishna Subramanian, L Aravind
SH3-fold-β-barrel domains of the chromo-like superfamily recognize epigenetic marks in eukaryotic proteins. Their provenance has been placed either in archaea, based on apparent structural similarity to chromatin-compacting Sul7d and Cren7 proteins, or in bacteria based on the presence of sequence homologs. Using sequence and structural evidence we establish that the archaeal Cren7/Sul7 proteins emerged from a zinc ribbon (ZnR) ancestor. Further, we show that the ancestral eukaryotic chromo-like domains evolved from bacterial versions, likely acquired from early endosymbioses, which already possessed an aromatic cage for recognition of modified amino-groups...
April 18, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29662614/transcriptional-orchestration-of-mitochondrial-homeostasis-in-a-cellular-model-of-pgc-1-related-coactivator-dependent-thyroid-tumor
#3
Solenne Dumont, Soazig Le Pennec, Audrey Donnart, Raluca Teusan, Marja Steenman, Catherine Chevalier, Rémi Houlgatte, Frédérique Savagner
The PGC-1 (Peroxisome proliferator-activated receptor Gamma Coactivator-1) family of coactivators (PGC-1α, PGC-1β, and PRC) plays a central role in the transcriptional control of mitochondrial biogenesis and oxidative phosphorylation (OXPHOS) processes. These coactivators integrate mitochondrial energy production into cell metabolism using complementary pathways. The XTC.UC1 cell line is a mitochondria-rich model of thyroid tumors whose biogenesis is almost exclusively dependent on PRC. Here we aim to propose an integrative view of the cellular pathways regulated by PRC through integration of cDNA and miRNA microarray data and chromatin immunoprecipitation results obtained from XTC...
March 23, 2018: Oncotarget
https://www.readbyqxmd.com/read/29618419/proximal-row-carpectomy-using-decellularized-dermal-allograft
#4
REVIEW
Remy V Rabinovich, Steven J Lee
Wrist arthritis is a common problem. When managed early, motion-sparing procedures can be performed with successful outcomes. Proximal row carpectomy (PRC) has demonstrated good functional results and high patient satisfaction with up to 20-year follow-up. The majority of patients with longer follow-up have, however, exhibited radiographic signs of progressive degeneration of the radiocapitate space. Although radiographic changes have not been shown to correlate with wrist pain and function, it remains a concern and questions the durability of the radiocapitate articulation with continued patient follow-up, especially those who underwent the original procedure at a younger age...
April 2018: Journal of Hand Surgery
https://www.readbyqxmd.com/read/29606688/building-capacity-in-the-sikh-asian-indian-community-to-lead-participatory-oral-health-projects
#5
Rucha Kavathe, Nadia Islam, Jennifer Zanowiak, Laura Wyatt, Hardayal Singh, Mary E Northridge
BACKGROUND: Lack of access to oral health care is a significant burden for disadvantaged populations, yet rarely draws the attention of policymakers or community leaders. OBJECTIVES: To understand how UNITED SIKHS identified oral health care as a priority need through its involvement in community-based participatory research (CBPR) initiatives and local data collection, thereby building its capacity to lead participatory oral health projects. METHODS: The foundation for the partnership between UNITED SIKHS and the New York University (NYU) Prevention Research Center (PRC) was the joint implementation of a CBPR project to prevent diabetes in the Sikh Asian Indian community...
2018: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29589871/temporal-dynamics-of-circadian-phase-shifting-response-to-consecutive-night-shifts-in-healthcare-workers-role-of-light-dark-exposure
#6
Julia E Stone, Tracey L Sletten, Michelle Magee, Saranea Ganesan, Megan D Mulhall, Allison Collins, Mark Howard, Steven W Lockley, Shantha M W Rajaratnam
Night shift workers show highly variable rates of circadian adaptation. This study examined the relationship between light exposure patterns and magnitude of circadian phase resetting in response to night shift work. In 21 participants (nursing and medical staff in an Intensive Care Unit [ICU]) circadian phase was measured using 6-sulphatoxymelatonin (aMT6s) at baseline (day/evening shifts of days off) and after 3 to 4 consecutive night shifts. Daily light exposure was examined relative to individual circadian phase to quantify light intensity in the phase delay and phase advance portions of the light phase response curve (PRC)...
March 28, 2018: Journal of Physiology
https://www.readbyqxmd.com/read/29582438/a-pilot-serosurvey-of-babesia-microti-in-chinese-blood-donors
#7
E M Bloch, Y Yang, M He, L Tonnetti, Y Liu, J Wang, Y Guo, H Li, D A Leiby, H Shan
BACKGROUND AND OBJECTIVES: Babesia spp. are tick-borne, intraerythrocytic protozoan parasites, several of which are transfusion-transmissible. Transfusion-transmitted babesiosis poses serious risk to a diverse patient population, including neonates, patients aged >50 years, the asplenic and the immunocompromised that are over-represented among transfusion recipients. Despite reports of B. microti and B. venatorum in People's Republic of China (PRC), no surveillance of blood donors for Babesia has previously been undertaken...
March 26, 2018: Vox Sanguinis
https://www.readbyqxmd.com/read/29577817/carbon-fexoy-magnetic-composites-obtained-from-pet-and-red-mud-residues-paracetamol-and-dye-oxidation
#8
Leonardo S Sousa, Poliane Chagas, Luiz Carlos Alves de Oliveira, Cinthia Soares de Castro
Composite materials from PET and red mud (RM) wastes were used as catalysts for environmental application such as the wastewater treatment. The PET-RM catalysts were obtained by mechanical mixture of the residues followed by thermal treatment under N2 atmosphere (300o C/1h). An additional activation of the composites with CO2 was investigated (at 800-900°C) to reduce the red mud basicity. The CO2 activation affected the composites surface area and reduced their carbon content. XRD revealed that the hematite (α-Fe2 O3 ) and maghemite/magnetite are the main iron oxides present in the composites...
March 26, 2018: Environmental Technology
https://www.readbyqxmd.com/read/29555181/shared-functions-of-perirhinal-and-parahippocampal-cortices-implications-for-cognitive-aging
#9
REVIEW
Sara N Burke, Leslie S Gaynor, Carol A Barnes, Russell M Bauer, Jennifer L Bizon, Erik D Roberson, Lee Ryan
A predominant view of perirhinal cortex (PRC) and postrhinal/parahippocampal cortex (POR/PHC) function contends that these structures are tuned to represent objects and spatial information, respectively. However, known anatomical connectivity, together with recent electrophysiological, neuroimaging, and lesion data, indicate that both brain areas participate in spatial and nonspatial processing. Instead of content-based organization, the PRC and PHC/POR may participate in two computationally distinct cortical-hippocampal networks: one network that is tuned to process coarse information quickly, forming gist-like representations of scenes/environments, and a second network tuned to process information about the specific sensory details that are necessary for discrimination across sensory modalities...
March 16, 2018: Trends in Neurosciences
https://www.readbyqxmd.com/read/29530011/clinical-and-misdiagnosed-analysis-of-primary-pulmonary-lymphoma-a-retrospective-study
#10
D Yao, L Zhang, P L Wu, X L Gu, Y F Chen, L X Wang, X Y Huang
BACKGROUND: The primary pulmonary lymphoma (PPL), with a low incidence, was highly misdiagnosed in clinic. The present study analyzes the clinical features, laboratory and imaging data, pathologic characteristics, and summarizes misdiagnosis reasons of PPL cases, aims to provide a better understanding and increase the accuracy of early diagnosis and minimize the misdiagnosis of PPL. METHODS: The clinical data of 19 cases were collected from the first affiliated hospital of Wenzhou medical university (PRC) from April 2010 to May 2016...
March 12, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29503013/platelet-rich-concentrate-enhances-mesenchymal-stem-cells-capacity-to-repair-focal-cartilage-injury-in-rabbits
#11
Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Faizal Manan, Tunku Kamarul
BACKGROUND: It has been previously suggested that the use of regenerative promoters, which include bone marrow-derived mesenchymal stem cells (MSCs) or natural growth factors supplement such as platelet-rich concentrate (PRC) could promote cartilage regeneration. However, the notion that the concurrent use of both promoters may provide a synergistic effect that improves the repair outcome of focal cartilage injury has not been previously demonstrated. This study was thus conducted to determine whether the concomitant use of PRC could further enhance the reparative potential of MSCs encapsulated in alginate transplanted into focal cartilage injury in rabbits...
February 21, 2018: Injury
https://www.readbyqxmd.com/read/29500023/bayesian-averaging-over-decision-tree-models-an-application-for-estimating-uncertainty-in-trauma-severity-scoring
#12
V Schetinin, L Jakaite, W Krzanowski
INTRODUCTION: For making reliable decisions, practitioners need to estimate uncertainties that exist in data and decision models. In this paper we analyse uncertainties of predicting survival probability for patients in trauma care. The existing prediction methodology employs logistic regression modelling of Trauma and Injury Severity Score (TRISS), which is based on theoretical assumptions. These assumptions limit the capability of TRISS methodology to provide accurate and reliable predictions...
April 2018: International Journal of Medical Informatics
https://www.readbyqxmd.com/read/29497183/religiosity-among-patients-with-schizophrenia-an-exploratory-study
#13
Davuluri Triveni, Sandeep Grover, Subho Chakrabarti
Aim: This study aimed to compare the religiosity and religious coping of patients with schizophrenia with a healthy control group and to assess the correlation between the level of religiosity and religious coping with residual psychopathology, level of functioning, and quality of life (QOL). Methodology: Patients of schizophrenia were assessed on religiousness measure scale, duke religion index (DUREL), brief religious coping scale (RCOPE), positive and negative symptom scale, and World Health Organization QOL-BREF version...
October 2017: Indian Journal of Psychiatry
https://www.readbyqxmd.com/read/29494903/performance-of-passive-sampling-with-low-density-polyethylene-membranes-for-the-estimation-of-freely-dissolved-ddx-concentrations-in-lake-environments
#14
Raffaella Borrelli, A Patricia Tcaciuc, Iason Verginelli, Renato Baciocchi, Licia Guzzella, Pietro Cesti, Luciano Zaninetta, Philip M Gschwend
Laboratory and field studies were used to evaluate the performance of low-density polyethylene (PE) passive samplers for assessing the freely dissolved concentrations of DDT and its degradates (DDD and DDE, together referred to as DDx) in an Italian lake environment. We tested commercially available 25 μm thick PE sheets as well as specially synthesized, 10 μm thick PE films which equilibrated with their surroundings more quickly. We measured PE-water partitioning coefficients (Kpew ) of the 10 μm thick PE films, finding good correspondence with previously reported values for thicker PE...
February 13, 2018: Chemosphere
https://www.readbyqxmd.com/read/29463128/distal-scaphoid-excision-in-treatment-of-symptomatic-scaphoid-nonunion-systematic-review-and-meta-analysis
#15
Cory K Mayfield, Daniel J Gould, Marie Dusch, Amir Mostofi
BACKGROUND: Current treatment options for persistent scaphoid nonunion are limited to salvage procedures such as proximal row carpectomy (PRC) or 4-corner fusion (4CF). Several small studies have demonstrated that distal scaphoid excision may provide a simpler alternative with faster recovery. The purpose of this study was to determine the efficacy of distal scaphoid excision as a treatment option for symptomatic scaphoid nonunion. METHODS: The MEDLINE and PubMed databases were searched for the use of distal scaphoid excision in scaphoid nonunions...
February 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29455241/cox-2-derived-pge-2-triggers-hyperplastic-renin-expression-and-hyperreninemia-in-aldosterone-synthase-deficient-mice
#16
Christian Karger, Katharina Machura, André Schneider, Christian Hugo, Vladimir T Todorov, Armin Kurtz
Pharmacological inhibition or genetic loss of function defects of the renin angiotensin aldosterone system (RAAS) causes compensatory renin cell hyperplasia and hyperreninemia. The triggers for the compensatory stimulation of renin synthesis and secretion in this situation may be multimodal. Since cyclooxygenase-2 (COX-2) expression in the macula densa is frequently increased in states of a defective RAAS, we have investigated a potential role of COX-2 and its derived prostaglandins for renin expression and secretion in aldosterone synthase-deficient mice (AS-/- ) as a model for a genetic defect of the RAAS...
February 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29454154/age-related-functional-changes-in-domain-specific-medial-temporal-lobe-pathways
#17
David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düzel
There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29448722/characterization-of-pulse-reverses-electroforming-on-hard-gold-coating
#18
Young-Min Byoun, Young-Tai Noh, Young-Geun Kim, Seung-Hwan Ma, Gwan-Hoon Kim
Effect of pulse reverse current (PRC) method on brass coatings electroplated from gold solution was investigated by various plating parameters such as plating duration, the anodic duty cycle, the anodic current density and the cathodic current density. The reversed current results in a significant change in the morphology of electrodeposits, improvement of the overall current efficiency and reduction of deposit porosity. With longer pulses, hemispherical surface features are generated, while larger grains result from shorter pulse widths...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447013/identification-of-three-types-of-%C3%AE-thalassemia-deletion-%C3%AE-21-9-%C3%AE-2-4-and-thai-and-their-frequencies-in-one-family-in-the-population-of-southern-guangxi-zhuang-autonomous-region-people-s-republic-of-china
#19
Wanrong Pang, Ju Long, Xunjin Weng, Qiongying Fan, Lei Sun, Zhijian Pan, Zuqian Fan
Different types of deletional α-thalassemia (α-thal) have been reported by researchers in China. This study describes one family carrying -α 21.9 (NG_000006.1: g.14373_36299delinsGGGAAGGGTGGGTGGGAATAACAGCTTTT), -α 2.4 (NG_000006.1: g.36860_39251del) and - - THAI (Thailand) (NG_000006.1: g.10664_44164del) alleles in Guangxi Zhuang Autonomous Region, People's Republic of China (PRC), and reports the frequencies of these types in the population of this region. The proband was a 4-year-old girl, who screened positive for thalassemia, although the thalassemia genotype results were normal when screened using the routine kits...
February 15, 2018: Hemoglobin
https://www.readbyqxmd.com/read/29440697/ectopic-expression-of-s28a-mutated-histone-h3-modulates-longevity-stress-resistance-and-cardiac-function-in-drosophila
#20
J P Joos, A R Saadatmand, C Schnabel, I Viktorinová, T Brand, M Kramer, S Nattel, D Dobrev, P Tomancak, J Backs, P Kleinbongard, G Heusch, K Lorenz, E Koch, S Weber, A El-Armouche
Histone H3 serine 28 (H3S28) phosphorylation and de-repression of polycomb repressive complex (PRC)-mediated gene regulation is linked to stress conditions in mitotic and post-mitotic cells. To better understand the role of H3S28 phosphorylation in vivo, we studied a Drosophila strain with ectopic expression of constitutively-activated H3S28A, which prevents PRC2 binding at H3S28, thus mimicking H3S28 phosphorylation. H3S28A mutants showed prolonged life span and improved resistance against starvation and paraquat-induced oxidative stress...
February 13, 2018: Scientific Reports
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