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https://www.readbyqxmd.com/read/29463128/distal-scaphoid-excision-in-treatment-of-symptomatic-scaphoid-nonunion-systematic-review-and-meta-analysis
#1
Cory K Mayfield, Daniel J Gould, Marie Dusch, Amir Mostofi
BACKGROUND: Current treatment options for persistent scaphoid nonunion are limited to salvage procedures such as proximal row carpectomy (PRC) or 4-corner fusion (4CF). Several small studies have demonstrated that distal scaphoid excision may provide a simpler alternative with faster recovery. The purpose of this study was to determine the efficacy of distal scaphoid excision as a treatment option for symptomatic scaphoid nonunion. METHODS: The MEDLINE and PubMed databases were searched for the use of distal scaphoid excision in scaphoid nonunions...
February 1, 2018: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/29455241/cox-2-derived-pge-2-triggers-hyperplastic-renin-expression-and-hyperreninemia-in-aldosterone-synthase-deficient-mice
#2
Christian Karger, Katharina Machura, André Schneider, Christian Hugo, Vladimir T Todorov, Armin Kurtz
Pharmacological inhibition or genetic loss of function defects of the renin angiotensin aldosterone system (RAAS) causes compensatory renin cell hyperplasia and hyperreninemia. The triggers for the compensatory stimulation of renin synthesis and secretion in this situation may be multimodal. Since cyclooxygenase-2 (COX-2) expression in the macula densa is frequently increased in states of a defective RAAS, we have investigated a potential role of COX-2 and its derived prostaglandins for renin expression and secretion in aldosterone synthase-deficient mice (AS-/- ) as a model for a genetic defect of the RAAS...
February 17, 2018: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29454154/age-related-functional-changes-in-domain-specific-medial-temporal-lobe-pathways
#3
David Berron, Katja Neumann, Anne Maass, Hartmut Schütze, Klaus Fliessbach, Verena Kiven, Frank Jessen, Magdalena Sauvage, Dharshan Kumaran, Emrah Düzel
There is now converging evidence from studies in animals and humans that the medial temporal lobes (MTLs) harbor anatomically distinct processing pathways for object and scene information. Recent functional magnetic resonance imaging studies in humans suggest that this domain-specific organization may be associated with a functional preference of the anterior-lateral part of the entorhinal cortex (alErC) for objects and the posterior-medial entorhinal cortex (pmErC) for scenes. As MTL subregions are differentially affected by aging and neurodegenerative diseases, the question was raised whether aging may affect the 2 pathways differentially...
January 31, 2018: Neurobiology of Aging
https://www.readbyqxmd.com/read/29448722/characterization-of-pulse-reverses-electroforming-on-hard-gold-coating
#4
Young-Min Byoun, Young-Tai Noh, Young-Geun Kim, Seung-Hwan Ma, Gwan-Hoon Kim
Effect of pulse reverse current (PRC) method on brass coatings electroplated from gold solution was investigated by various plating parameters such as plating duration, the anodic duty cycle, the anodic current density and the cathodic current density. The reversed current results in a significant change in the morphology of electrodeposits, improvement of the overall current efficiency and reduction of deposit porosity. With longer pulses, hemispherical surface features are generated, while larger grains result from shorter pulse widths...
March 1, 2018: Journal of Nanoscience and Nanotechnology
https://www.readbyqxmd.com/read/29447013/identification-of-three-types-of-%C3%AE-thalassemia-deletion-%C3%AE-21-9-%C3%AE-2-4-and-thai-and-their-frequencies-in-one-family-in-the-population-of-southern-guangxi-zhuang-autonomous-region-people-s-republic-of-china
#5
Wanrong Pang, Ju Long, Xunjin Weng, Qiongying Fan, Lei Sun, Zhijian Pan, Zuqian Fan
Different types of deletional α-thalassemia (α-thal) have been reported by researchers in China. This study describes one family carrying -α 21.9 (NG_000006.1: g.14373_36299delinsGGGAAGGGTGGGTGGGAATAACAGCTTTT), -α 2.4 (NG_000006.1: g.36860_39251del) and - - THAI (Thailand) (NG_000006.1: g.10664_44164del) alleles in Guangxi Zhuang Autonomous Region, People's Republic of China (PRC), and reports the frequencies of these types in the population of this region. The proband was a 4-year-old girl, who screened positive for thalassemia, although the thalassemia genotype results were normal when screened using the routine kits...
February 15, 2018: Hemoglobin
https://www.readbyqxmd.com/read/29440697/ectopic-expression-of-s28a-mutated-histone-h3-modulates-longevity-stress-resistance-and-cardiac-function-in-drosophila
#6
J P Joos, A R Saadatmand, C Schnabel, I Viktorinová, T Brand, M Kramer, S Nattel, D Dobrev, P Tomancak, J Backs, P Kleinbongard, G Heusch, K Lorenz, E Koch, S Weber, A El-Armouche
Histone H3 serine 28 (H3S28) phosphorylation and de-repression of polycomb repressive complex (PRC)-mediated gene regulation is linked to stress conditions in mitotic and post-mitotic cells. To better understand the role of H3S28 phosphorylation in vivo, we studied a Drosophila strain with ectopic expression of constitutively-activated H3S28A, which prevents PRC2 binding at H3S28, thus mimicking H3S28 phosphorylation. H3S28A mutants showed prolonged life span and improved resistance against starvation and paraquat-induced oxidative stress...
February 13, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29437062/mid-term-outcomes-of-routine-proximal-row-carpectomy-compared-with-proximal-row-carpectomy-with-dorsal-capsular-interposition-arthroplasty-for-the-treatment-of-late-stage-arthropathy-of-the-wrist
#7
COMPARATIVE STUDY
M P Gaspar, P P Pham, C D Pankiw, S M Jacoby, E K Shin, A L Osterman, P M Kane
AIMS: The aims of this study were to compare the mid-term outcomes of patients with late-stage arthritis of the wrist treated with proximal row carpectomy (PRC) and dorsal capsular interposition (DCI) arthroplasty with a matched cohort treated with routine PRC alone. PATIENTS AND METHODS: A total of 25 arthritic wrists (24 patients) with pre-existing degenerative changes of the proximal capitate and/or the lunate fossa of the radius were treated with PRC + DCI over a ten-year period...
February 2018: Bone & Joint Journal
https://www.readbyqxmd.com/read/29425697/descriptive-findings-of-the-va-polytrauma-rehabilitation-centers-tbi-model-systems-national-database
#8
Susan Ropacki, Risa Nakase-Richardson, Leah Farrell-Carnahan, Greg J Lamberty, Xinyu Tang
OBJECTIVE: Present initial descriptive findings from the Veterans Affairs (VA) Polytrauma Rehabilitation Centers (PRC) Traumatic Brain Injury (TBI) Model Systems (MS) National Database. DESIGN: Prospective cohort study. SETTING: VA PRC TBIMS National Database. PARTICIPANTS: 712 service members and veterans with TBI who consented to participate between January 2010 and June 2015. INTERVENTIONS: Not applicable...
February 6, 2018: Archives of Physical Medicine and Rehabilitation
https://www.readbyqxmd.com/read/29415665/prognostic-implications-of-polycomb-proteins-ezh2-suz12-and-eed1-and-histone-modification-by-h3k27me3-in-sarcoma
#9
Yong Jin Cho, Soo Hee Kim, Eun Kyung Kim, Jung Woo Han, Kyoo-Ho Shin, Hyuk Hu, Kyung Sik Kim, Young Deuk Choi, Sunghoon Kim, Young Han Lee, Jin-Suck Suh, Joong Bae Ahn, Hyun Cheol Chung, Sung Hoon Noh, Sun Young Rha, Sung-Taek Jung, Hyo Song Kim
BACKGROUND: Polycomb repressive complex 2 (PRC2; formed by EZH2, SUZ12, and EED protein subunits) and PRC1 (BMI1 protein) induce gene silencing through histone modification by H3K27me3. In the present study, we characterized the PRC expression pattern and its clinical implication in sarcoma. METHODS: Using immunohistochemistry, we analyzed PRC expression in 105 sarcoma patients with 5 subtypes: synovial sarcoma (n = 18), rhabdomyosarcoma (n = 28), Ewing sarcoma (n = 15), osteosarcoma (n = 30), and others (n = 14)...
February 7, 2018: BMC Cancer
https://www.readbyqxmd.com/read/29413422/prc1-linking-cytokinesis-chromosomal-instability-and-cancer-evolution
#10
REVIEW
Jing Li, Marlene Dallmayer, Thomas Kirchner, Julian Musa, Thomas G P Grünewald
Cytokinesis is the final event of the cell cycle dividing one cell into two daughter cells. The protein regulator of cytokinesis (PRC)1 is essential for cytokinesis and normal cell cleavage. Deregulation of PRC1 causes cytokinesis defects that promote chromosomal instability (CIN) and thus tumor heterogeneity and cancer evolution. Consistently, abnormal PRC1 expression correlates with poor patient outcome in various malignancies, which may be caused by PRC1-mediated CIN and aneuploidy. Here, we review the physiological functions of PRC1 in cell cycle regulation and its contribution to tumorigenesis and intratumoral heterogeneity...
January 2018: Trends in Cancer
https://www.readbyqxmd.com/read/29398991/comparative-evaluation-of-surgical-procedures-with-clinical-equipoise-the-unique-perspective-of-our-hand-therapy-colleagues
#11
Joseph J Schreiber, Susan Clark, Jeffrey Yao
Background: There are several accepted surgical treatment options available for carpal tunnel syndrome, thumb carpometacarpal joint (CMC), osteoarthritis (OA), and wrist degenerative joint disease. Questions/Purposes: We sought to obtain the views and preferences from a cohort of certified hand therapists (CHT) and hypothesized that this source may identify differences in procedures that are otherwise widely believed to have clinical equipoise. Methods: Five hundred twelve CHTs were surveyed regarding their experience, volume, and referral base along with their subjective assessments and preferences regarding open versus endoscopic carpal tunnel release (CTR), various surgical procedures for CMC OA, and proximal row carpectomy (PRC) versus 4-corner fusion (4-CF)...
February 2018: HSS Journal: the Musculoskeletal Journal of Hospital for Special Surgery
https://www.readbyqxmd.com/read/29394958/real-time-pcr-diagnosis-of-schistosoma-japonicum-in-low-transmission-areas-of-china
#12
Pei He, Catherine A Gordon, Gail M Williams, Yuesheng Li, Yuanyuan Wang, Junjian Hu, Darren J Gray, Allen G Ross, Donald Harn, Donald P McManus
BACKGROUND: Schistosomiasis in the People's Republic of China (PRC) can be traced back to antiquity. In the past 60 years, the Chinese government has made great efforts to control this persistent disease with elimination slated by 2020 through the implementation of a comprehensive control strategy. This strategy aims to reduce the role of bovines and humans as sources of infection as a pre-requisite for elimination through transmission interruption. The goal of elimination will be achievable only by the implementation of a sustainable surveillance and control system, with sensitive diagnosis a key feature so that the true disease burden is not underestimated...
January 31, 2018: Infectious Diseases of Poverty
https://www.readbyqxmd.com/read/29394266/impact-of-transgenic-soybean-expressing-cry1ac-and-cry1f-proteins-on-the-non-target-arthropod-community-associated-with-soybean-in-brazil
#13
Luiz H Marques, Antonio C Santos, Boris A Castro, Nicholas P Storer, Jonathan M Babcock, Miles D Lepping, Verissimo Sa, Valéria F Moscardini, Dwain M Rule, Odair A Fernandes
Field-scale studies that examine the potential for adverse effects of Bt crop technology on non-target arthropods may supplement data from laboratory studies to support an environmental risk assessment. A three year field study was conducted in Brazil to evaluate potential for adverse effects of cultivating soybean event DAS-81419-2 that produces the Cry1Ac and Cry1F proteins. To do so, we examined the diversity and abundance of non-target arthropods (NTAs) in Bt soybean in comparison with its non-Bt near isoline, with and without conventional insecticide applications, in three Brazilian soybean producing regions...
2018: PloS One
https://www.readbyqxmd.com/read/29384871/salvage-radiochemotherapy-for-lymph-node-recurrence-after-radical-surgery-of-esophageal-cancer
#14
Yi-Qin Zhou, Nai-Xin Ding, Li-Jun Wang, Wei Liu, Ming Jiang, Jin-Cheng Lu
To evaluate the efficacy of salvage radiochemotherapy (SRC) in patients with recurrent lymph node after radical surgery in esophageal cancer.This study enrolled 58 patients with esophageal squamous cell carcinoma who underwent SRC for lymph node recurrence after radical surgery from August 2011 to November 2015 at our hospital. Survival rates were calculated by the Kaplan-Meier method with the log-rank test. Multivariate analysis was conducted using the Cox model.The overall 1-, 3-, and 5-year survival rates after radical surgery were 94...
February 2018: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29383276/long-term-outcome-and-secondary-operations-after-proximal-row-carpectomy-or-four-corner-arthrodesis
#15
John Barton Williams, Hadley Weiner, Andrew R Tyser
Background  Proximal row carpectomy (PRC) and four-corner arthrodesis (FCA) are common surgical procedures used to treat degenerative wrist conditions; however, complications and failures can occur. Purpose  This study aimed to investigate and compare the long-term rate of secondary surgeries including conversion to total wrist arthrodesis in patients who underwent PRC or FCA. Materials and Methods  A retrospective chart review of all patients who underwent PRC or FCA in the past 20 years at a tertiary referral institution and associated Veterans Affairs (VA) hospital was performed...
February 2018: Journal of Wrist Surgery
https://www.readbyqxmd.com/read/29379165/muc1-c-activates-polycomb-repressive-complexes-and-downregulates-tumor-suppressor-genes-in-human-cancer-cells
#16
REVIEW
Hasan Rajabi, Masayuki Hiraki, Donald Kufe
The PRC2 and PRC1 complexes are aberrantly expressed in human cancers and have been linked to decreases in patient survival. MUC1-C is an oncoprotein that is also overexpressed in diverse human cancers and is associated with a poor prognosis. Recent studies have supported a previously unreported function for MUC1-C in activating PRC2 and PRC1 in cancer cells. In the regulation of PRC2, MUC1-C (i) drives transcription of the EZH2 gene, (ii) binds directly to EZH2, and (iii) enhances occupancy of EZH2 on target gene promoters with an increase in H3K27 trimethylation...
January 30, 2018: Oncogene
https://www.readbyqxmd.com/read/29358333/ehrlichia-chaffeensis-trp120-effector-targets-and-recruits-host-polycomb-group-proteins-for-degradation-to-promote-intracellular-infection
#17
Shubhajit Mitra, Paige S Dunphy, Seema Das, Bing Zhu, Tian Luo, Jere W McBride
Ehrlichia chaffeensis has a group of well-characterized type I secreted tandem repeat protein (TRP) effectors that have moonlighting capabilities. TRPs modulate various cellular processes, reprogram host gene transcription as nucleomodulins, function as ubiquitin ligases, and directly activate conserved host cell signaling pathways to promote E. chaffeensis infection. One TRP interacting host target is polycomb group ring finger protein 5 (PCGF5), a member of the polycomb group (PcG) protein family, and a component of the polycomb repressive complex 1 (PRC1)...
January 22, 2018: Infection and Immunity
https://www.readbyqxmd.com/read/29354452/arthroscopic-proximal-row-carpectomy-using-the-volar-central-portal
#18
Montserrat Ocampos Hernandez, Fernando Corella Montoya, Miguel Del Cerro Gutierrez, Ricardo Larrainzar Garijo
Proximal row carpectomy (PRC) is a well-accepted procedure for the treatment of degenerative lesions of the wrist and advance Kienböck disease. This procedure has been classically described as an open procedure but recently has been reported as an arthroscopic one. Arthroscopic PRC has several advantages such as minimal damage to the dorsal and volar ligaments as well as there being no need to detach the capsule, which can facilitate earlier mobilization and can decrease postoperative stiffness. In addition, there is a reduced risk of the interosseous posterior nerve being injured, and the proprioception system continues to function...
August 2017: Arthroscopy Techniques
https://www.readbyqxmd.com/read/29352372/improving-pet-quantification-of-small-animal-68ga-dota-labeled-pet-ct-studies-by-using-a-ct-based-positron-range-correction
#19
Jacobo Cal-Gonzalez, Juan José Vaquero, Joaquín L Herraiz, Mailyn Pérez-Liva, María Luisa Soto-Montenegro, Santiago Peña-Zalbidea, Manuel Desco, José Manuel Udías
PURPOSE: Image quality of positron emission tomography (PET) tracers that emits high-energy positrons, such as Ga-68, Rb-82, or I-124, is significantly affected by positron range (PR) effects. PR effects are especially important in small animal PET studies, since they can limit spatial resolution and quantitative accuracy of the images. Since generators accessibility has made Ga-68 tracers wide available, the aim of this study is to show how the quantitative results of [68Ga]DOTA-labeled PET/X-ray computed tomography (CT) imaging of neuroendocrine tumors in mice can be improved using positron range correction (PRC)...
January 19, 2018: Molecular Imaging and Biology: MIB: the Official Publication of the Academy of Molecular Imaging
https://www.readbyqxmd.com/read/29347589/synchronization-scenarios-in-the-winfree-model-of-coupled-oscillators
#20
Rafael Gallego, Ernest Montbrió, Diego Pazó
Fifty years ago Arthur Winfree proposed a deeply influential mean-field model for the collective synchronization of large populations of phase oscillators. Here we provide a detailed analysis of the model for some special, analytically tractable cases. Adopting the thermodynamic limit, we derive an ordinary differential equation that exactly describes the temporal evolution of the macroscopic variables in the Ott-Antonsen invariant manifold. The low-dimensional model is then thoroughly investigated for a variety of pulse types and sinusoidal phase response curves (PRCs)...
October 2017: Physical Review. E
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