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https://www.readbyqxmd.com/read/27909849/monitoring-contaminants-of-emerging-concern-from-tertiary-wastewater-treatment-plants-using-passive-sampling-modelled-with-performance-reference-compounds
#1
Tamanna Sultana, Craig Murray, M Ehsanul Hoque, Chris D Metcalfe
The Lake Simcoe watershed in Ontario, Canada is an important recreational area and a recharge zone for groundwater resources. Lake Simcoe is a relatively shallow lotic system that has been impacted by urban development, recreation, industry and agriculture. As part of a watershed management plan, six wastewater treatment plants (WWTPs) located in this catchment basin were selected to measure the inputs of contaminants of emerging concern (CECs) of wastewater origin. These WWTPs were recently upgraded to tertiary treatment for phosphorus removal...
December 2016: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/27890248/proximal-row-carpectomy-on-manual-workers-17%C3%A2-patients-followed-for-an-average-of-6%C3%A2-years
#2
S Delclaux, D Israel, C Aprédoaei, M Rongières, P Mansat
: Proximal row carpectomy (PRC) is indicated for the treatment of SNAC or SLAC wrist with preservation of the midcarpal joint. Our hypothesis was that PRC is not appropriate for treating advanced wrist osteoarthritis in patients who carry out heavy manual work. Twenty-three PRCs were performed on 21 patients, 5 women and 16 men with an average age of 54 years (33-77). All patients performed manual work; 11 of them performed heavy manual work. Etiologies were: SLAC wrist in 14 cases (2 stage III, 11 stage II, and 1 stage I) and SNAC wrist in 9 cases (6 stage IIIB and 3 stage IIB)...
December 2016: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/27859925/material-specificity-drives-medial-temporal-lobe-familiarity-but-not-hippocampal-recollection
#3
Alex Kafkas, Ellen M Migo, Robin G Morris, Michael D Kopelman, Daniela Montaldi, Andrew R Mayes
The specific role of the perirhinal (PRC), entorhinal (ERC) and parahippocampal cortices (PHC) in supporting familiarity-based recognition remains unknown. An fMRI study explored whether these medial temporal lobe (MTL) structures responded in the same way or differentially to familiarity as a function of stimulus type at recognition. A secondary aim was to explore whether the hippocampus responds in the same way to equally strong familiarity and recollection and whether this is influenced by the kind of stimulus involved...
November 16, 2016: Hippocampus
https://www.readbyqxmd.com/read/27830540/multifaceted-role-of-the-polycomb-group-gene-ezh2-in-hematological-malignancies
#4
REVIEW
Goro Sashida, Atsushi Iwama
Polycomb repressive complex (PRC) is a critical regulator of normal tissue homeostasis as well as tumorigenesis. EZH2, an enzymatic subunit of PRC2, is a histone H3K27 methyltransferase that functions in the regulation of gene silencing. EZH2 overexpression was first identified in prostate and breast cancers and is associated with poor clinical outcome. Subsequently, gain- and loss-of-function mutations of EZH2 have been identified in various tumors, including hematological malignancies, implicating EZH2 as either an oncogene or a tumor suppressor gene, depending on the cancer type...
November 9, 2016: International Journal of Hematology
https://www.readbyqxmd.com/read/27824037/structure-of-the-ribosome-post-recycling-complex-probed-by-chemical-cross-linking-and-mass-spectrometry
#5
Kristin Kiosze-Becker, Alessandro Ori, Milan Gerovac, André Heuer, Elina Nürenberg-Goloub, Umar Jan Rashid, Thomas Becker, Roland Beckmann, Martin Beck, Robert Tampé
Ribosome recycling orchestrated by the ATP binding cassette (ABC) protein ABCE1 can be considered as the final-or the first-step within the cyclic process of protein synthesis, connecting translation termination and mRNA surveillance with re-initiation. An ATP-dependent tweezer-like motion of the nucleotide-binding domains in ABCE1 transfers mechanical energy to the ribosome and tears the ribosome subunits apart. The post-recycling complex (PRC) then re-initiates mRNA translation. Here, we probed the so far unknown architecture of the 1-MDa PRC (40S/30S·ABCE1) by chemical cross-linking and mass spectrometry (XL-MS)...
November 8, 2016: Nature Communications
https://www.readbyqxmd.com/read/27818980/randomized-clinical-trial-between-proximal-row-carpectomy-and-the-four-corner-fusion-for-patients-with-stage-ii-snac
#6
Marcio Aurelio Aita, Edison Kenji Nakano, Henrique de Lazari Schaffhausser, Walter Yoshinori Fukushima, Edison Noboru Fujiki
OBJECTIVE: To compare the outcomes of patients with stage II SNAC submitted to surgical treatment by proximal row carpectomy (PRC) or four-corner fusion (FCF). METHOD: Twenty-seven patients aged 18-59 years (mean 37.52 years) were included. Thirteen patients underwent PRC in Group A, and 14 underwent FCF of the wrist in Group B. Evaluations were made before and after surgery with follow-up between 45 and 73 months. Range of motion (ROM); pain assessment with a visual analog scale (VAS); grip strength; disability of the arm, shoulder, and hand (DASH); and return to work were evaluated...
September 2016: Revista Brasileira de Ortopedia
https://www.readbyqxmd.com/read/27812323/intrinsic-cellular-properties-and-connectivity-density-determine-variable-clustering-patterns-in-randomly-connected-inhibitory-neural-networks
#7
Scott Rich, Victoria Booth, Michal Zochowski
The plethora of inhibitory interneurons in the hippocampus and cortex play a pivotal role in generating rhythmic activity by clustering and synchronizing cell firing. Results of our simulations demonstrate that both the intrinsic cellular properties of neurons and the degree of network connectivity affect the characteristics of clustered dynamics exhibited in randomly connected, heterogeneous inhibitory networks. We quantify intrinsic cellular properties by the neuron's current-frequency relation (IF curve) and Phase Response Curve (PRC), a measure of how perturbations given at various phases of a neurons firing cycle affect subsequent spike timing...
2016: Frontiers in Neural Circuits
https://www.readbyqxmd.com/read/27798662/assessing-potential-impact-of-bt-eggplants-on-non-target-arthropods-in-the-philippines
#8
Mario V Navasero, Randolph N Candano, Desiree M Hautea, Randy A Hautea, Frank A Shotkoski, Anthony M Shelton
Studies on potential adverse effects of genetically engineered crops are part of an environmental risk assessment that is required prior to the commercial release of these crops. Of particular concern are non-target organisms (NTOs) that provide important ecosystem services. Here, we report on studies conducted in the Philippines over three cropping seasons with Bt eggplants expressing Cry1Ac for control of the eggplant fruit and shoot borer (EFSB), Leucinodes orbonalis, to examine potential effects on field abundance, community composition, structure and biodiversity of NTO's, particularly non-target arthropod (NTA) communities...
2016: PloS One
https://www.readbyqxmd.com/read/27789709/concerted-action-of-pgc-1-related-coactivator-prc-and-c-myc-in-the-stress-response-to-mitochondrial-dysfunction
#9
Natalie Gleyzer, Richard C Scarpulla
PRC (PGC-1-related coactivator) has a dual function in growth-regulated mitochondrial biogenesis and as a sensor of metabolic stress. PRC induction by mitochondrial inhibitors, intracellular ROS, or topoisomerase I inhibition orchestrates an inflammatory program associated with the adaptation to cellular stress. Activation of this program is accompanied by the coordinate expression of c-MYC, which is linked kinetically to that of PRC in response to multiple stress inducers. Here, we show that the c-MYC inhibitor, 10058-F4, blocks the induction of c-MYC, PRC and representative PRC-dependent stress genes by the respiratory chain uncoupler, CCCP...
October 27, 2016: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/27785464/phase-dependent-modulation-of-oscillatory-phase-and-synchrony-by-long-lasting-depolarizing-inputs-in-central-neurons
#10
Satoshi Watanabe, Moritoshi Hirono
Oscillatory neural activities have been implicated in various types of information processing in the CNS. The procerebral (PC) lobe of the land mollusk Limax valentianus shows an ongoing oscillatory local field potential (LFP). Olfactory input increases both the frequency and spatial synchrony of the LFP oscillation by a nitric oxide (NO)-mediated mechanism, but how NO modulates the activity in a specific manner has been unclear. In the present study, we used electrical stimulation and NO uncaging to systematically analyze the response of the LFP oscillation and found phase-dependent effects on phase shifting and synchrony...
September 2016: ENeuro
https://www.readbyqxmd.com/read/27775628/chocolate-classification-by-an-electronic-nose-with-pressure-controlled-generated-stimulation
#11
Luis F Valdez, Juan Manuel Gutiérrez
In this work, we will analyze the response of a Metal Oxide Gas Sensor (MOGS) array to a flow controlled stimulus generated in a pressure controlled canister produced by a homemade olfactometer to build an E-nose. The built E-nose is capable of chocolate identification between the 26 analyzed chocolate bar samples and four features recognition (chocolate type, extra ingredient, sweetener and expiration date status). The data analysis tools used were Principal Components Analysis (PCA) and Artificial Neural Networks (ANNs)...
October 20, 2016: Sensors
https://www.readbyqxmd.com/read/27756854/the-time-course-of-effect-of-multilayer-release-methylphenidate-hydrochloride-capsules-a-randomized-double-blind-study-of-adults-with-adhd-in-a-simulated-adult-workplace-environment
#12
Sharon B Wigal, Tim Wigal, Ann Childress, Graeme A E Donnelly, Joseph L Reiz
OBJECTIVE: The aim of this study is to assess the onset and duration of efficacy of multilayer-release methylphenidate (PRC-063) over 16 hr compared with placebo in adults with ADHD using the simulated adult workplace environment. METHOD: After dose-optimization with PRC-063, participants entered a double-blind, placebo-controlled, crossover phase. Primary outcome measure was the Permanent Product Measure of Performance (PERMP) total score measured pre-dose and from 1 to 16 hr post-dose...
October 17, 2016: Journal of Attention Disorders
https://www.readbyqxmd.com/read/27754956/entrainment-maps-a-new-tool-for-understanding-properties-of-circadian-oscillator-models
#13
Casey O Diekman, Amitabha Bose
Circadian oscillators found across a variety of species are subject to periodic external light-dark forcing. Entrainment to light-dark cycles enables the circadian system to align biological functions with appropriate times of day or night. Phase response curves (PRCs) have been used for decades to gain valuable insights into entrainment; however, PRCs may not accurately describe entrainment to photoperiods with substantial amounts of both light and dark due to their reliance on a single limit cycle attractor...
October 17, 2016: Journal of Biological Rhythms
https://www.readbyqxmd.com/read/27721320/high-on-treatment-platelet-reactivity-risk-factors-and-5-year-outcomes-in-patients-with-acute-myocardial-infarction
#14
Martin Jakl, Robert Sevcik, Ilona Fatorova, Jan M Horacek, Radek Pudil
OBJECTIVE: The aim of the present study was to assess long-term prognostic value of high on-treatment platelet reactivity (HTPR) in patients after acute myocardial infarction (MI) and its association with possible risk factors. METHODS: This prospective, case-control study was an observation of 198 patients who had acute MI. Response to aspirin and clopidogrel was assessed using impedance aggregometry. Patients were divided into groups of adequate response, dual poor responsiveness (DPR), poor responsiveness to aspirin (PRA), and poor responsiveness to clopidogrel (PRC)...
October 5, 2016: Anatolian Journal of Cardiology
https://www.readbyqxmd.com/read/27702610/multi-template-analysis-of-human-perirhinal-cortex-in-brain-mri-explicitly-accounting-for-anatomical-variability
#15
Long Xie, John B Pluta, Sandhitsu R Das, Laura E M Wisse, Hongzhi Wang, Lauren Mancuso, Dasha Kliot, Brian B Avants, Song-Lin Ding, José V Manjón, David A Wolk, Paul A Yushkevich
RATIONAL: The human perirhinal cortex (PRC) plays critical roles in episodic and semantic memory and visual perception. The PRC consists of Brodmann areas 35 and 36 (BA35, BA36). In Alzheimer's disease (AD), BA35 is the first cortical site affected by neurofibrillary tangle pathology, which is closely linked to neural injury in AD. Large anatomical variability, manifested in the form of different cortical folding and branching patterns, makes it difficult to segment the PRC in MRI scans...
October 1, 2016: NeuroImage
https://www.readbyqxmd.com/read/27689162/prenatal-risk-calculation-prc-3-0-an-extended-doe-based-first-trimester-screening-algorithm-allowing-for-early-blood-sampling
#16
E Merz, C Thode, B Eiben, S Wellek
AIM: Both previous versions of the German PRC algorithm developed by our group for routine first-trimester screening relied on the assumption that maternal blood sampling and fetal ultrasonography are performed at the same visit of a pregnant women. In this paper we present an extension of our method allowing also for constellations where this synchronization is abandoned through preponing blood sampling to dates before 11 weeks of gestation. METHODS: In contrast to the directly measured concentrations of the serum parameters PAPP-A and free ß-hCG, the logarithmically transformed values could be shown to admit the construction of reference bands covering the whole range from 16 to 84 mm CRL [corresponding to 63 to 98 days of gestation]...
March 2016: Ultrasound International Open
https://www.readbyqxmd.com/read/27683887/neurons-as-oscillators
#17
Klaus M Stiefel, G Bard Ermentrout
Regularly spiking neurons can be described as oscillators. Here we review some of the insights gained from this conceptualization and their relevance for systems neuroscience. First, we explain how a regularly spiking neuron can be viewed as an oscillator, and how the phase-response-curve (PRC) describes the response the neuron's spike times to small perturbations. We then discuss the meaning of the PRC for a single neuron's spiking behavior and review the PRCs measured from a variety of neurons in a range of spiking regimes...
September 28, 2016: Journal of Neurophysiology
https://www.readbyqxmd.com/read/27664948/overexpression-of-long-noncoding-rna-neat1-promotes-cell-proliferation-invasion-and-migration-in-endometrial-endometrioid-adenocarcinoma
#18
Zhiguo Li, Dianjun Wei, Chao Yang, Honggang Sun, Tao Lu, Defeng Kuang
Long noncoding RNAs (lncRNAs) are emerging as important modulators in the biological processes and tumorigenesis. However, whether lncRNAs are involved in endometrial endometrioid adenocarcinoma (EEC) remains unclear. In the present study, we explored the expression pattern, clinical significance and biological function of nuclear enriched abundant transcript 1 (NEAT1) in EEC. The expression levels of NEAT1 were elevated in EEC tissues and cell lines, and higher expression levels of NEAT1 were positively correlated with FIGO stage and lymph node metastasis...
September 21, 2016: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/27651984/platelet-rich-concentrate-in-serum-free-medium-enhances-osteogenic-differentiation-of-bone-marrow-derived-human-mesenchymal-stromal-cells
#19
Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Malliga Raman Murali, Azlina A Abbas, Tunku Kamarul
Previous studies have shown that platelet concentrates used in conjunction with appropriate growth media enhance osteogenic differentiation of human mesenchymal stromal cells (hMSCs). However, their potential in inducing osteogenesis of hMSCs when cultured in serum free medium has not been explored. Furthermore, the resulting osteogenic molecular signatures of the hMSCs have not been compared to standard osteogenic medium. We studied the effect of infrequent supplementation (8-day interval) of 15% non-activated platelet-rich concentrate (PRC) in serum free medium on hMSCs proliferation and differentiation throughout a course of 24 days, and compared the effect with those cultured in a standard osteogenic medium (OM)...
2016: PeerJ
https://www.readbyqxmd.com/read/27629725/pik3ca-mutations-in-resected-small-cell-lung-cancer
#20
Na Han, Qiao-Yuan Cheng, Bo Chen, Ju-Fen Cai, Xiao-Jia Wang, Cai-Jin Lou, Jing Qin, Wei-Wu Ye, Lei Lei, Hong-Yang Lu
BACKGROUND: Despite advances in chemotherapy and radiotherapy in recent decades, the prognosis for small cell lung cancer (SCLC) patients is still poor. Targeted therapies in SCLC must be applied systemically to target not only the primary tumor but also metastases. The phosphatidylinositol 3-kinase (PI3K)/AKT pathways play a key regulatory function in the survival, proliferation, energy metabolism and cellular architecture advantages of malignant cells. The phosphatidylinositol 3-kinase catalytic α (PIK3CA) gene, which encodes the p110α catalytic subunit, plays a key role in the activation of AKT downstream signaling and mammary tumor progression...
May 2016: Advances in Clinical and Experimental Medicine: Official Organ Wroclaw Medical University
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