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https://www.readbyqxmd.com/read/28821609/insulin-like-growth-factor-1-signalling-is-essential-for-mitochondrial-biogenesis-and-mitophagy-in-cancer-cells
#1
Amy Lyons, Michael Coleman, Sarah Riis, Cedric Favre, Ciara H O'Flanagan, Alexander V Zhdanov, Dmitri B Papkovsky, Stephen D Hursting, Rosemary O'Connor
Mitochondrial activity and metabolic reprogramming influence the phenotype of cancer cells and resistance to targeted therapy. We previously established that an Insulin-like Growth Factor 1 (IGF-1)-inducible mitochondrial UTP carrier (PNC1/SLC25A33) promotes cell growth. This prompted us to investigate whether IGF signaling is essential for mitochondrial maintenance in cancer cells, and whether this contributes to therapy resistance. Here, we show that IGF-1 stimulates mitochondrial biogenesis in a range of cell lines...
August 18, 2017: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/28821525/point-of-care-washing-of-allogeneic-red-blood-cells-for-the-prevention-of-transfusion-related-respiratory-complications-war-prc-a-protocol-for-a-multicenter-randomised-clinical-trial-in-patients-undergoing-cardiac-surgery
#2
Matthew A Warner, Ian J Welsby, Phillip J Norris, Christopher C Silliman, Sarah Armour, Erica D Wittwer, Paula J Santrach, Laurie A Meade, Lavonne M Liedl, Chelsea M Nieuwenkamp, Brian Douthit, Camille M van Buskirk, Phillip J Schulte, Rickey E Carter, Daryl J Kor
INTRODUCTION: The transfusion-related respiratory complications, transfusion-related acute lung injury (TRALI) and transfusion-associated circulatory overload (TACO), are leading causes of transfusion-related morbidity and mortality. At present, there are no effective preventive strategies with red blood cell (RBC) transfusion. Although mechanisms remain incompletely defined, soluble biological response modifiers (BRMs) within the RBC storage solution may play an important role. Point-of-care (POC) washing of allogeneic RBCs may remove these BRMs, thereby mitigating their impact on post-transfusion respiratory complications...
August 18, 2017: BMJ Open
https://www.readbyqxmd.com/read/28810844/effect-of-tolvaptan-on-renal-handling-of-water-and-sodium-gfr-and-central-hemodynamics-in-autosomal-dominant-polycystic-kidney-disease-during-inhibition-of-the-nitric-oxide-system-a-randomized-placebo-controlled-double-blind-crossover-study
#3
Safa Al Therwani, My Emma Sofie Malmberg, Jeppe Bakkestroem Rosenbaek, Jesper Noergaard Bech, Erling Bjerregaard Pedersen
BACKGROUND: Tolvaptan slows progression of autosomal dominant polycystic kidney disease (ADPKD) by antagonizing the vasopressin-cAMP axis. Nitric oxide (NO) stimulates natriuresis and diuresis, but its role is unknown during tolvaptan treatment in ADPKD. METHODS: Eighteen patients with ADPKD received tolvaptan 60 mg or placebo in a randomized, placebo-controlled, double blind, crossover study. L-NMMA (L-NG-monomethyl-arginine) was given as a bolus followed by continuous infusion during 60 min...
August 15, 2017: BMC Nephrology
https://www.readbyqxmd.com/read/28758948/polycomb-repressor-complex-2-in-genomic-instability-and-cancer
#4
REVIEW
Zoe Veneti, Kalliopi K Gkouskou, Aristides G Eliopoulos
Polycomb repressor complexes PRC1 and PRC2 regulate chromatin compaction and gene expression, and are widely recognized for their fundamental contributions to developmental processes. Herein, we summarize the existing evidence and molecular mechanisms linking PRC-mediated epigenetic aberrations to genomic instability and malignancy, with a particular focus on the role of deregulated PRC2 in tumor suppressor gene expression, the DNA damage response, and the fidelity of DNA replication. We also discuss some of the recent advances in the development of pharmacological and dietary interventions affecting PRC2, which point to promising applications for the prevention and management of human malignancies...
July 30, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28756188/long-term-outcomes-of-proximal-row-carpectomy-a-series-of-62-cases
#5
B Chedal-Bornu, D Corcella, A Forli, F Moutet, M Bouyer
The aim of this study was to determine and analyze the functional and radiographic outcomes after proximal row carpectomy (PRC). We hypothesized that this surgery could restore wrist mobility and function in case of radiocarpal osteoarthritis or severe carpal trauma. Sixty-two patients who had undergone PRC were included in this study: 44 patients with wrist osteoarthritis (11 SNAC, 24 SLAC, 3 Kienböck's disease, 6 other) and 18 patients with severe carpal trauma. Each patient underwent clinical (pain, range of motion, grip strength, functional scores) and radiographic evaluations...
July 26, 2017: Hand Surgery and Rehabilitation
https://www.readbyqxmd.com/read/28752156/accounting-for-the-confound-of-meninges-in-segmenting-entorhinal-and-perirhinal-cortices-in-t1-weighted-mri
#6
Long Xie, Laura E M Wisse, Sandhitsu R Das, Hongzhi Wang, David A Wolk, Jose V Manjón, Paul A Yushkevich
Quantification of medial temporal lobe (MTL) cortices, including entorhinal cortex (ERC) and perirhinal cortex (PRC), from in vivo MRI is desirable for studying the human memory system as well as in early diagnosis and monitoring of Alzheimer's disease. However, ERC and PRC are commonly over-segmented in T1-weighted (T1w) MRI because of the adjacent meninges that have similar intensity to gray matter in T1 contrast. This introduces errors in the quantification and could potentially confound imaging studies of ERC/PRC...
October 2016: Medical Image Computing and Computer-assisted Intervention: MICCAI ..
https://www.readbyqxmd.com/read/28744318/optimization-of-classification-strategies-of-acetowhite-temporal-patterns-towards-improving-diagnostic-performance-of-colposcopy
#7
Karina Gutiérrez-Fragoso, Héctor Gabriel Acosta-Mesa, Nicandro Cruz-Ramírez, Rodolfo Hernández-Jiménez
Efforts have been being made to improve the diagnostic performance of colposcopy, trying to help better diagnose cervical cancer, particularly in developing countries. However, improvements in a number of areas are still necessary, such as the time it takes to process the full digital image of the cervix, the performance of the computing systems used to identify different kinds of tissues, and biopsy sampling. In this paper, we explore three different, well-known automatic classification methods (k-Nearest Neighbors, Naïve Bayes, and C4...
2017: Computational and Mathematical Methods in Medicine
https://www.readbyqxmd.com/read/28740537/the-anti-inflammatory-effects-of-invigorating-kidney-and-supplementing-qi-chinese-herbal-formulae-in-asthma-patients
#8
Lingwen Kong, Hongying Zhang, Yuxue Cao, Jingjing Le, Jinfeng Wu, Baojun Liu, Meixia Chen, Yijie Du, Jia Wang, Genfa Wang, Tao Yi, Xianmei Zhou, Gang Wang, Qing Miao, Suyun Li, Naiqing Zhao, Jingcheng Dong
BACKGROUND: The theories of Shen-reinforcement and Qi-supplementation are important in asthma treatment based on traditional Chinese medicine theories. Early studies suggested that Invigorating Kidney and Supplementing Qi herbal formulae, Bu Shen Fang Chuan (BSFC) and Bu Shen Yi Qi (BSYQ), conveyed promising results in asthma treatment. However, the efficacy and safety of the formulae need to be further investigated by a randomized double-blind clinical trial. METHODS: 328 eligible patients were randomly sent to BSFC, BSYQ, and placebo group...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28736407/implementing-physical-activity-recommendations-in-a-tri-ethnic-rural-community-through-a-community-university-partnership
#9
Sally M Davis, Theresa H Cruz, Julia Meredith Hess, Richard Kozoll, Janet Page-Reeves
BACKGROUND: A tri-ethnic rural community with limited resources and a university Prevention Research Center (PRC) developed a partnership to promote evidence-based physical activity. OBJECTIVE: The purpose of this study was to investigate how a community-university partnership can disseminate and implement ἀe Commu nity Guide's recommendations for increasing physical activity and create a model for other under-resourced communities experiencing high rates of chronic disease...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/28727659/patient-release-criteria-following-radioactive-iodine-131-treatment-in-the-light-of-international-practice-where-does-south-africa-fit-in
#10
Modisenyane S Mongane, William I D Rae
The release from hospital of patients treated with radioactive iodine-131 (I) remains a controversial issue as a result of the range of guidelines implemented by national regulatory bodies responsible for radiation protection in various countries worldwide. The aim of this study was to review and analyse the literature on patient release criteria (PRC) applied internationally in an attempt to achieve a justifiable approach to setting equivalent criteria in South Africa. In 2016, the South African Department of Health, Directorate: Radiation Control added conditions (numbers 50 and 90), to licences to use radioactive nuclides...
July 19, 2017: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/28715496/transition-of-phase-response-properties-and-singularity-in-the-circadian-limit-cycle-of-cultured-cells
#11
Satoshi Koinuma, Hiroshi Kori, Isao T Tokuda, Kazuhiro Yagita, Yasufumi Shigeyoshi
The circadian system has been regarded as a limit cycle oscillator constructed by the integrated interaction of clock genes and proteins. Here, we investigated a mammalian circadian oscillation geometrically before and after a perturbation. We detected the singular point and transition from a type 1 to type 0 phase response curve (PRC) and determined the embedding dimension to show how many variables are needed to describe the limit cycle oscillation and relaxation process after a perturbation. As a perturbation, forskolin (FK) was administered to Rat-1 cells expressing the Per2::luc gene...
2017: PloS One
https://www.readbyqxmd.com/read/28708376/self-healing-nanotextured-vascular-like-materials-mode-i-crack-propagation
#12
Min Wook Lee, Soumyadip Sett, Seongpil An, Sam S Yoon, Alexander L Yarin
Here, we investigate crack propagation initiated from an initial notch in a self-healing material. The crack propagation in the core-shell nanofiber mats formed by coelectrospinning and the composites reinforced by them is in focus. All samples are observed from the crack initiation until complete failure. Due to the short-time experiments done on purpose, the resin and cure released from the cores of the core-shell nanofibers could not achieve a complete curing and stop crack growth, especially given the fact that no heating was used...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28679862/mysm1-2a-dub-is-an-epigenetic-regulator-in-human-melanoma-and-contributes-to-tumor-cell-growth
#13
Christina Wilms, Carsten M Kroeger, Adelheid V Hainzl, Ishani Banik, Clara Bruno, Ioanna Krikki, Vida Farsam, Meinhard Wlaschek, Martina V Gatzka
Histone modifying enzymes, such as histone deacetylases (HDACs) and polycomb repressive complex (PRC) components, have been implicated in regulating tumor growth, epithelial-mesenchymal transition, tumor stem cell maintenance, or repression of tumor suppressor genes - and may be promising targets for combination therapies of melanoma and other cancers. According to recent findings, the histone H2A deubiquitinase 2A-DUB/Mysm1 interacts with the p53-axis in hematopoiesis and tissue differentiation in mice, in part by modulating DNA-damage responses in stem cell and progenitor compartments...
June 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28673769/age-related-deficits-in-the-mnemonic-similarity-task-for-objects-and-scenes
#14
Shauna M Stark, Craig E L Stark
Using the Mnemonic Similarity Task (MST), we have demonstrated an age-related impairment in lure discrimination, or the ability to recognize an item as distinct from one that was similar, but not identical to one viewed earlier. A growing body of evidence links these behavioral changes to age-related alterations in the hippocampus. In this study, we sought to evaluate a novel version of this task, utilizing scenes that might emphasize the role of the hippocampus in contextual and spatial processing. In addition, we investigated whether, by utilizing two stimulus classes (scenes and objects), we could also interrogate the roles of the PRC and PHC in aging...
July 1, 2017: Behavioural Brain Research
https://www.readbyqxmd.com/read/28671737/the-phase-response-and-state-space-of-slow-wave-contractions-in-the-small-intestine
#15
Sean P Parsons, Jan D Huizinga
The interstitial cells of Cajal (ICC) generate electrical oscillations in the gut. Synchronisation of the ICC population is required for generation of coherent electrical waves ("slow waves") that cause muscular contraction and thereby move gut content. The phase response curve (PRC) is an experimental measure of the dynamical rules governing a population of oscillators, that determine their synchrony, and gives an experimental window onto the state space of the oscillator, its dynamical landscape. We measured the PRC of slow wave contractions in the mouse small intestine by the novel combination of diameter mapping and single pulse electrical field stimulation...
July 3, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/28668267/measurement-of-phase-resetting-curves-using-optogenetic-barrage-stimuli
#16
Matthew H Higgs, Charles J Wilson
BACKGROUND: The phase resetting curve (PRC) is a primary measure of a rhythmically firing neuron's responses to synaptic input, quantifying the change in phase of the firing oscillation as a function of the input phase. PRCs provide information about whether neurons will synchronize due to synaptic coupling or shared input. However, PRC estimation has been limited to in vitro preparations where stable intracellular recordings can be obtained and background activity is minimal, and new methods are required for in vivo applications...
June 28, 2017: Journal of Neuroscience Methods
https://www.readbyqxmd.com/read/28652965/a-protocol-for-manual-segmentation-of-medial-temporal-lobe-subregions-in-7%C3%A2-tesla-mri
#17
D Berron, P Vieweg, A Hochkeppler, J B Pluta, S-L Ding, A Maass, A Luther, L Xie, S R Das, D A Wolk, T Wolbers, P A Yushkevich, E Düzel, L E M Wisse
Recent advances in MRI and increasing knowledge on the characterization and anatomical variability of medial temporal lobe (MTL) anatomy have paved the way for more specific subdivisions of the MTL in humans. In addition, recent studies suggest that early changes in many neurodegenerative and neuropsychiatric diseases are better detected in smaller subregions of the MTL rather than with whole structure analyses. Here, we developed a new protocol using 7 Tesla (T) MRI incorporating novel anatomical findings for the manual segmentation of entorhinal cortex (ErC), perirhinal cortex (PrC; divided into area 35 and 36), parahippocampal cortex (PhC), and hippocampus; which includes the subfields subiculum (Sub), CA1, CA2, as well as CA3 and dentate gyrus (DG) which are separated by the endfolial pathway covering most of the long axis of the hippocampus...
2017: NeuroImage: Clinical
https://www.readbyqxmd.com/read/28652613/flipping-between-polycomb-repressed-and-active-transcriptional-states-introduces-noise-in-gene-expression
#18
Gozde Kar, Jong Kyoung Kim, Aleksandra A Kolodziejczyk, Kedar Nath Natarajan, Elena Torlai Triglia, Borbala Mifsud, Sarah Elderkin, John C Marioni, Ana Pombo, Sarah A Teichmann
Polycomb repressive complexes (PRCs) are important histone modifiers, which silence gene expression; yet, there exists a subset of PRC-bound genes actively transcribed by RNA polymerase II (RNAPII). It is likely that the role of Polycomb repressive complex is to dampen expression of these PRC-active genes. However, it is unclear how this flipping between chromatin states alters the kinetics of transcription. Here, we integrate histone modifications and RNAPII states derived from bulk ChIP-seq data with single-cell RNA-sequencing data...
June 26, 2017: Nature Communications
https://www.readbyqxmd.com/read/28652430/the-contribution-of-mmp-7-promoter-polymorphisms-in-renal-cell-carcinoma
#19
Cheng-Hsi Liao, Wen-Shin Chang, Pei-Shin Hu, Hsi-Chin Wu, Shih-Wei Hsu, Yen-Fang Liu, Shih-Ping Liu, Huey-Shan Hung, DA-Tian Bau, Chia-Wen Tsai
BACKGROUND/AIM: Mounting evidence has suggested that polymorphisms in the promoters of matrix metalloproteinase (MMP) genes are associated with the risk of many types of cancer, but no study has ever explored these polymorphisms as biomarkers for renal cell cancer (RCC). Recently, it was suggested that serum MMP-7 levels have both diagnostic and prognostic potential for RCC. In this study, we focused on the contribution of two functional polymorphisms in the promoter region of MMP-7 (A-181G and C-153T) to RCC...
July 2017: In Vivo
https://www.readbyqxmd.com/read/28651891/neuroanatomical-alterations-and-synaptic-plasticity-impairment-in-the-perirhinal-cortex-of-the-ts65dn-mouse-model-of-down-syndrome
#20
Vincenzo Roncacé, Costanza Burattini, Fiorenza Stagni, Sandra Guidi, Andrea Giacomini, Marco Emili, Giorgio Aicardi, Renata Bartesaghi
Down syndrome (DS), a genetic condition due to triplication of Chromosome 21, is characterized by numerous neurodevelopmental alterations and intellectual disability. Individuals with DS and DS mouse models are impaired in several memory domains, including hippocampus-dependent declarative (spatial, in rodents) memory and visual recognition memory, a form of memory in which the perirhinal cortex (PRC) plays a fundamental role. The anatomo-functional substrates of hippocampus-dependent memory impairment have been largely elucidated in the Ts65Dn mouse model of DS...
June 23, 2017: Neurobiology of Disease
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