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Eline Huizing, Cornelis G Vos, Robin G Hulsebos, Peter J van den Akker, Gert Jan de Borst, Çağdaş Ünlü
Objectives  Guidelines recommend routine patching to prevent restenosis following carotid endarterectomy, mainly based on studies performed many years ago with different perioperative care and medical treatment compared with current standards. Aim of the present study was to compare primary closure (PRC) versus patch closure (PAC) in a contemporary cohort of patients. Methods  Consecutive patients treated by carotid endarterectomy for symptomatic stenosis between January 2006 and April 2016 were retrospectively analyzed...
April 2018: Surgery Journal
Tom Maudrich, Rouven Kenville, Jöran Lepsien, Arno Villringer, Patrick Ragert
Mirror Activity (MA) describes involuntarily occurring muscular activity in contralateral homologous limbs during unilateral movements. This phenomenon has not only been reported in patients with neurological disorders (i.e. Mirror Movements) but has also been observed in healthy adults referred to as physiological Mirror Activity (pMA). However, despite recent hypotheses, the underlying neural mechanisms and structural correlates of pMA still remain insufficiently described. We investigated the structural correlates of pMA during isometric contractions of hand muscles with increasing force demands on a whole-brain level by means of voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS)...
June 15, 2018: Scientific Reports
Xiaojun Deng, Youpeng Xu
This study developed the potential regulation capacity (PRC) and actual regulation capacity (ARC) to characterize the flood regulation function of river systems in the delta plains. Spatial autocorrelation and the grey relational analysis were then employed to investigate the spatial-temporal change of the flood regulation function in the urbanization process, of which the results revealed its spatial coupling and quantitative relation with the urbanization process and river systems changes in the Taihu Plain...
May 1, 2018: Science of the Total Environment
Elizabeth E Krans, Stephanie Bobby, Michael England, Robert H Gedekoh, Judy C Chang, Bawn Maguire, Patty Genday, Dennis H English
OBJECTIVE: To evaluate the impact of women-centered substance abuse treatment programming on outcomes among pregnant women with opioid use disorder (OUD). METHODS: We compared two retrospective cohorts of pregnant women with OUD on buprenorphine maintenance therapy who delivered an infant at the University of Pittsburgh from 2014 to 2016. Cohort 1 was composed of pregnant women who received women-centered OUD treatment services through the Pregnancy Recovery Program (PRC) and Cohort 2 was composed of pregnant women who received buprenorphine at OUD programs without women-centered services (non-PRC)...
May 24, 2018: Addictive Behaviors
C Turni, R Singh, P J Blackall
OBJECTIVE: Determine if there is a link between virulence-associated genes of Haemophilus parasuis and the genotype and serovar of isolates. METHODS: Isolates of H. parasuis from 38 farms across six Australian states, representing all serovars present in Australia, were assessed for the presence of virulence-associated genes (vtaA, hhdBA, fhuA, lsgB and capD). Enterobacterial Repetitive Intergenic Consensus PCR (ERIC-PCR) and multilocus sequence typing (MLST), together with existing knowledge of the serovar of the isolates and the health status of the source pig, were used to examine 75 Australian isolates of H...
June 2018: Australian Veterinary Journal
Ding Y, Xia B-H, Teng Y-S, Zhuo G-C, Leng J-H
Variations in mitochondrial genome have been found to be associated with hearing loss. Of these, the mitochondrial 12S rRNA and tRNASer(UCN) are the hot-spots for pathogenic variants associated with deafness. To understand the putative role of mitochondrial DNA (mtDNA) variants in hearing loss, we recently screened the variants in mitochondrial genomes in patients with deafness from the Hangzhou area of Zhejiang Province, People's Republic of China (PRC). In this study, we describe a maternally-inherited Han Chinese family with high penetrance of hearing loss, notably, the penetrance of hearing loss in this family were 80...
December 2017: Balkan Journal of Medical Genetics: BJMG
Pallavi Lamba, Lauren E Foley, Patrick Emery
Light is one of the chief environmental cues that reset circadian clocks. In Drosophila , CRYPTOCHROME (CRY) mediates acute photic resetting of circadian clocks by promoting the degradation of TIMELESS (TIM) in a cell-autonomous manner. Thus, even circadian oscillators in peripheral organs can independently perceive light in Drosophila However, there is substantial evidence for non-autonomous mechanisms of circadian photoreception in the brain. We have previously shown that the Morning (M) and Evening (E) oscillators are critical light-sensing neurons that cooperate to shift the phase of circadian behavior in response to light input...
June 6, 2018: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
Hui-Wen Wu, Shulin Deng, Haiying Xu, Hui-Zhu Mao, Jun Liu, Qi-Wen Niu, Huan Wang, Nam-Hai Chua
Dispersed H3K27 trimethylation (H3K27me3) of the AGAMOUS (AG) genomic locus is mediated by CURLY LEAF (CLF), a component of the Polycomb Repressive Complex (PRC) 2. Previous reports have shown that the AG second intron, which confers AG tissue-specific expression, harbors sequences targeted by several positive and negative regulators. Using RACE reverse transcription polymerase chain reaction, we found that the AG intron 2 encodes several noncoding RNAs. RNAi experiment showed that incRNA4 is needed for CLF repressive activity...
June 4, 2018: New Phytologist
Wasim I M Sultan, José Crispim
BACKGROUND: While health needs and expenditure in the Occupied Palestinian Territories (OPT) are growing, the international donations are declining and the economic situation is worsening. The purpose of this paper is twofold, to evaluate the productive efficiency of public hospitals in West Bank and to study contextual factors contributing to efficiency differences. METHODS: This study examined technical efficiency among 11 public hospitals in West Bank from 2010 through 2015 targeting a total of 66 observations...
May 29, 2018: BMC Health Services Research
Leslie S Gaynor, Sarah A Johnson, Jack Morgan Mizell, Keila T Campos, Andrew P Maurer, Russell M Bauer, Sara N Burke
The perirhinal cortex (PRC) supports associative memory and perception, and PRC dysfunction impairs animals' abilities to associate stimulus features across sensory modalities. PRC damage also leads to deficits in discriminating between stimuli that share features. Although PRC-dependent stimulus discrimination has been shown to be impaired with advanced age, data regarding the abilities of older adults and other animals to form PRC-dependent associations have been equivocal. Moreover, the extent to which similar neural computations within the PRC support associative memory versus discrimination abilities have not been directly examined...
June 2018: Behavioral Neuroscience
Ömer Faruk Boran, Fatih Mehmet Yazar, Maruf Boran, Aykut Urfalıoğlu, Zeyneb Bakacak, Mürşide Yıldız, Fethi Gül, Selma Güler
BACKGROUND The aim of this study was to find a simple and easily accessible scoring system that could predict the development of sepsis in the preseptic period. MATERIAL AND METHODS The study included 161 patients with a basal sequential organ failure assessment (SOFA) value of 2 or more. The sepsis group (n=83) comprised patients with infection reported in culture results; the control group (n=78) comprised patients not showing evidence of infection in blood, urine, and phlegm cultures; samples were taken on three consecutive days...
May 27, 2018: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
Kairon Ribeiro Dias, Carolina Barbosa de Andrade, Taíssa Tomaz Wait, Raiane Chamon, Michelle Mickael Ammari, Vera Mendes Soviero, Leandro Lobo, Aline de Almeida Neves, Lucianne Cople Maia, Andréa Fonseca-Gonçalves
OBJECTIVES: This randomized controlled clinical trial evaluated the efficacy of sealing carious dentin in controlling the progression of lesions in primary molars for 2-year follow-up. MATERIALS AND METHODS: Children (6.79 ± 1.81 years, n = 28) presenting primary molars with occlusal caries in the outer half of dentine were randomized and allocated into 2 groups: test (sealing caries with a flowable resin - SC) and control (partial removal of caries followed by restoration - PRC)...
May 22, 2018: Journal of Dentistry
Xiaoyu Shu, Mei Mei, Linqiang Ma, Zhihong Wang, Shumin Yang, Jinbo Hu, Ying Song, Wenwen He, Ting Luo, Qingfeng Cheng, Yue Wang, Qianna Zhen, Qifu Li
Plasma aldosterone/renin ratio (ARR) is a useful method for primary aldosteronism (PA) screening. However some confounders, such as medications and dietary, affect plasma renin and aldosterone levels, resulting in false-negative or -positive plasma ARR. This study investigated the association between postmenopausal osteoporosis (PMO) and plasma ARR. Bone mineral density (BMD) was measured by dual-energy X-ray-absorptiometry (DXA) in 324 normotensive postmenopausal women. Based on clinical characteristics and BMD, 186 and 96 subjects were diagnosed as PMO and osteopenia respectively, and the remaining 42 subjects were grouped as normal BMD...
May 22, 2018: Journal of Human Hypertension
Camila Delgado, Laura Florez, Ivonne Lollett, Christine Lopez, Shiva Kangeyan, Hansi Kumari, Marios Stylianou, Robert J Smiddy, Lisa Schneper, Robert T Sautter, George Szatmari, Kalai Mathee
The progression of cystic fibrosis (CF) from an acute to a chronic disease is often associated with the conversion of the opportunistic pathogen Pseudomonas aeruginosa from a nonmucoid form to a mucoid form in the lung. This conversion involves the overproduction of the exopolysaccharide alginate, whose production is under control of the AlgT/U sigma factor. This factor is regulated posttranslationally by an extremely unstable process and has been commonly attributed to mutations in the algT/U gene. By exploiting this unstable phenotype, we isolated 34 spontaneous nonmucoid variants arising from the mucoid strain PDO300, a PAO1 derivative containing the mucA22 allele commonly found in mucoid CF isolates...
May 21, 2018: Journal of Bacteriology
Frank Jermusek, Chelsea Benedict, Emma Dreischmeier, Michael Brand, Michael Uder, Justin J Jeffery, Frank N Ranallo, William E Fahl
While computed tomography (CT) is now commonly used and considered to be clinically valuable, significant DNA double-strand breaks (γ-H2AX foci) in white blood cells from adult and pediatric CT patients have been frequently reported. In this study to determine whether γ-H2AX foci and X-ray-induced naked DNA damage are suppressed by administration of the PrC-210 radioprotector, human blood samples were irradiated in a CT scanner at 50-150 mGy with or without PrC-210, and γ-H2AX foci were scored. X-ray-induced naked DNA damage was also studied, and the DNA protective efficacy of PrC-210 was compared against 12 other common "antioxidants...
May 21, 2018: Radiation Research
Leire Mijangos, Haizea Ziarrusta, Ailette Prieto, Oihane Zugazua, Olatz Zuloaga, Maitane Olivares, Aresatz Usobiaga, Albrecht Paschke, Nestor Etxebarria
The calibration of two passive samplers for the determination of 20 emerging organic compounds in seawater is described in this work: i) a new version of polar organic chemical integrative sampler (POCIS) containing 100 mg of mixed-mode anion exchanger (Strata X-AW) and 100 mg of polymeric HLB (Plexa) sorbent materials and using a highly porous Nylon membrane (30-μm pore size) and ii) polyethersulfone (PES) hollow fibre. Among the studied contaminants, herbicides, hormones, life style products (stimulants and artificial sweeteners), industrial chemicals (corrosion inhibitor and fluorinated compounds), personal care products and several pharmaceuticals were included...
August 1, 2018: Talanta
Lutz Ahrens, Atlasi Daneshvar, Anna E Lau, Jenny Kreuger
Three passive sampler types including Chemcatcher® C18 , polar organic chemical integrative sampler-hydrophilic-lipophilic balance (POCIS-HLB) and silicone rubber (SR) based on polydimethylsiloxane (PDMS) were evaluated for 124 legacy and current used pesticides at two sampling locations in southern Sweden over a period of 6 weeks and compared to time-proportional composite active sampling. In addition, an in situ calibration was performed resulting in median in situ sampling rates (RS , L day-1 ) of 0...
May 11, 2018: Science of the Total Environment
Tabia Henry Akintobi, Elise Lockamy, Lisa Goodin, Natalie D Hernandez, Tanesha Slocumb, Daniel Blumenthal, Ronald Braithwaite, Larry Leeks, Micah Rowland, Thomas Cotton, LaShawn Hoffman
BACKGROUND: The community-based participatory research (CBPR)-driven health needs assessment was a tool used to inform community-led, -implemented, and -sustained research and prevention strategies. METHODS: The Morehouse School of Medicine Prevention Research Center (MSM PRC) research and prevention initiatives are implemented in direct response to priorities identified through this process and tool. Led by a community-majority coalition board, the assessment coupled state and city secondary data with primary survey data collected by and from community residents...
2018: Progress in Community Health Partnerships: Research, Education, and Action
Abigail S Joyce, Robert M Burgess
Performance reference compounds (PRCs) are often added to passive samplers prior to field deployments to provide information about mass transfer kinetics between the sampled environment and the passive sampler. Their popularity has resulted in different methods of varying complexity to estimate mass transfer and better estimate freely dissolved concentrations (Cfree ) of targeted compounds. Three methods for describing a mass transfer model are commonly used: a first order (FO) kinetic method, a non-linear least squares (NLS) fitting of sampling rate, and a diffusion (DIF) method...
May 10, 2018: Environmental Toxicology and Chemistry
Yashan Feng, Shijie Zhu, Liguo Wang, Lei Chang, Bingbing Yan, Xiaozhe Song, Shaokang Guan
The poor corrosion resistance of biodegradable magnesium alloys is the dominant factor that limits their clinical application. In this study, to deal with this challenge, fluoride coating was prepared on Mg-Zn-Ca alloy as the inner coating and then hydroxyapatite (HA) coating as the outer coating was deposited on fluoride coating by pulse reverse current electrodeposition (PRC-HA/MgF2 ). As a comparative study, the microstructure and corrosion properties of the composite coating with the outer coating fabricated by traditional constant current electrodeposition (TED-HA/MgF2 ) were also investigated...
June 2017: Bioactive Materials
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