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https://www.readbyqxmd.com/read/29203649/ph-sensitive-vibrational-probe-reveals-a-cytoplasmic-protonated-cluster-in-bacteriorhodopsin
#1
Victor A Lorenz-Fonfria, Mattia Saita, Tzvetana Lazarova, Ramona Schlesinger, Joachim Heberle
Infrared spectroscopy has been used in the past to probe the dynamics of internal proton transfer reactions taking place during the functional mechanism of proteins but has remained mostly silent to protonation changes in the aqueous medium. Here, by selectively monitoring vibrational changes of buffer molecules with a temporal resolution of 6 µs, we have traced proton release and uptake events in the light-driven proton-pump bacteriorhodopsin and correlate these to other molecular processes within the protein...
December 4, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29202092/china-s-engagement-with-development-assistance-for-health-in-africa
#2
Mohon Shajalal, Junfang Xu, Jun Jing, Madeleine King, Jie Zhang, Peicheng Wang, Jennifer Bouey, Feng Cheng
Background: As an emerging donor in health related development across the world, particularly towards Africa, the People's Republic of China (PRC) has been increasing its influence within the field of global public health over the past few decades. Yet between the period of 2000 and 2013, little is known about the scope, scale and priority of China's grant-making programs. Methods: Based on data sourced from the China Aid Database (version-1.2), descriptive analyses were applied to analyze the features of 531 health related projects that were undertaken between 2000 and 2013...
2017: Global Health Research and Policy
https://www.readbyqxmd.com/read/29198313/modifiers-of-radiation-effects-in-the-eye
#3
REVIEW
Norman J Kleiman, Fiona A Stewart, Eric J Hall
World events, including the threat of radiological terrorism and the fear of nuclear accidents, have highlighted an urgent need to develop medical countermeasures to prevent or reduce radiation injury. Similarly, plans for manned spaceflight to a near-Earth asteroid or journey to Mars raise serious concerns about long-term effects of space radiation on human health and the availability of suitable therapeutic interventions. At the same time, the need to protect normal tissue from the deleterious effects of radiotherapy has driven considerable research into the design of effective radioprotectors...
November 2017: Life Sciences in Space Research
https://www.readbyqxmd.com/read/29193239/calibration-of-silicone-rubber-rods-as-passive-samplers-for-pesticides-at-two-different-flow-velocities-modelling-of-sampling-rates-under-water-boundary-layer-and-polymer-control
#4
Alexis Martin, Christelle Margoum, Antoine Jolivet, Azziz Assoumani, Bachir El Moujahid, Jerome Randon, Marina Coquery
There is a need to determine time-weighted average concentrations of polar contaminants such as pesticides by passive sampling in environmental waters. Calibration data for silicone rubber (SR)-based passive samplers are lacking for this class of compounds. The calibration data, sampling rate (Rs ) and partition coefficient between SR and water (Ksw ) were precisely determined for 23 pesticides and 13 candidate performance reference compounds (PRCs) in a laboratory calibration system over 14 d for two water flow velocities, 5 cm s-1 and 20 cm s-1 ...
November 28, 2017: Environmental Toxicology and Chemistry
https://www.readbyqxmd.com/read/29192021/contributions-of-primate-prefrontal-cortex-and-medial-temporal-lobe-to-temporal-order-memory
#5
Yuji Naya, He Chen, Cen Yang, Wendy A Suzuki
Neuropsychological and neurophysiological studies have emphasized the role of the prefrontal cortex (PFC) in maintaining information about the temporal order of events or items for upcoming actions. However, the medial temporal lobe (MTL) has also been considered critical to bind individual events or items to their temporal context in episodic memory. Here we characterize the contributions of these brain areas by comparing single-unit activity in the dorsal and ventral regions of macaque lateral PFC (d-PFC and v-PFC) with activity in MTL areas including the hippocampus (HPC), entorhinal cortex, and perirhinal cortex (PRC) as well as in area TE during the encoding phase of a temporal-order memory task...
November 30, 2017: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29167032/using-the-evidence-based-practice-service-nursing-bundle-to-increase-patient-satisfaction
#6
Mary Kate Dilts Skaggs, Juli F Daniels, Angela J Hodge, Valerie L DeCamp
ABSTRACTINTRODUCTION: Patient satisfaction and patient experience goals are often linked to financial consequences. Although the link does exist, the bottom line is not only about money; it's about providing a quality experience for ED patients and creating an environment that engages staff. Evidence-based practice (EBP) strategies that have positive impact on patient perceptions of their ED care and increased satisfaction ratings include AIDET, Hourly Rounding, and Bedside Shift Report, which incorporate updates of test results and explanations of events occurring during a patient's visit...
November 19, 2017: Journal of Emergency Nursing: JEN: Official Publication of the Emergency Department Nurses Association
https://www.readbyqxmd.com/read/29158038/sexual-and-reproductive-health-services-and-related-health-information-on-pregnancy-resource-center-websites-a%C3%A2-statewide-content-analysis
#7
Andrea Swartzendruber, Anna Newton-Levinson, Ashley E Feuchs, Ashley L Phillips, Jennifer Hickey, Riley J Steiner
BACKGROUND: Pregnancy resource centers (PRCs) are nonprofit organizations with a primary mission of promoting childbirth among pregnant women. Given a new state grant program to publicly fund PRCs, we analyzed Georgia PRC websites to describe advertised services and related health information. METHODS: We systematically identified all accessible Georgia PRC websites available from April to June 2016. Entire websites were obtained and coded using defined protocols...
November 17, 2017: Women's Health Issues: Official Publication of the Jacobs Institute of Women's Health
https://www.readbyqxmd.com/read/29138488/structural-basis-of-adaptor-mediated-protein-degradation-by-the-tail-specific-pdz-protease-prc
#8
Ming-Yuan Su, Nilanjan Som, Chia-Yun Wu, Shih-Chieh Su, Yi-Ting Kuo, Lu-Chu Ke, Meng-Ru Ho, Shiou-Ru Tzeng, Ching-Hao Teng, Dominique Mengin-Lecreulx, Manjula Reddy, Chung-I Chang
Peptidoglycan (PG) is a highly cross-linked, protective mesh-like sacculus that surrounds the bacterial cytoplasmic membrane. Expansion of PG is tightly coupled to growth of a bacterial cell and requires hydrolases to cleave the cross-links for insertion of nascent PG material. In Escherichia coli, a proteolytic system comprising the periplasmic PDZ-protease Prc and the lipoprotein adaptor NlpI contributes to PG enlargement by regulating cellular levels of MepS, a cross-link-specific hydrolase. Here, we demonstrate how NlpI binds Prc to facilitate the degradation of its substrate MepS by structural and mutational analyses...
November 15, 2017: Nature Communications
https://www.readbyqxmd.com/read/29137941/acute-and-sub-acute-oral-toxicity-studies-of-the-aqueous-extract-from-radix-radix-with-cortex-and-cortex-of-psammosilene-tunicoides-in-mice-and-rats
#9
Yi-Chen, Min-Xuan Wu, Jie-Liu, Xiao-Jie Ma, Jin-Li Shi, Sheng-Nan Wang, Zhi-Quan Zheng, Jian-You Guo
ETHNOPHARMACOLOGICAL RELEVANCE: Psammosilene tunicoides is one of the important ingredients of a famous Chinese traditional medicine formulation "Yunnan Baiyao". Also, this plant is commonly used as an anodyne and hemostatic agent in southwest China. Currently, little toxicological information is available on its safety following prolonged use. AIM OF THE STUDY: In this study, we sought to evaluate the toxicity of the three different parts of Psammosilene tunicoides: Psammosilenes Radix (PR), Psammosilenes Radix with Cortex (PRC) and Psammosilenes Cortex (PC) by acute and sub-acute toxicity studies...
November 11, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29124980/prenatal-diagnosis-and-molecular-analysis-of-a-large-novel-deletion-js-causing-%C3%AE-0-thalassemia
#10
Jinru Cao, Shuzhen He, Yudong Pu, Jingjing Liu, Fuping Liu, Jun Feng
α-Thalassemia (α-thal) is a very common single gene hereditary disease caused by large deletions or point mutations of the α-globin gene cluster in tropical and subtropical regions of the world. Here, we report for the first time, a novel large α-thal deletion in a Chinese family from Jiangsu Province, People's Republic of China (PRC), which removes almost the entire α2 and α1 genes from the α-globin gene cluster. Thus, it was named the Jiangsu deletion (- -(JS)) on the α-globin gene cluster causing α(0)-thal...
November 10, 2017: Hemoglobin
https://www.readbyqxmd.com/read/29108942/how-landmark-suitability-shapes-recognition-memory-signals-for-objects-in-the-medial-temporal-lobes
#11
Chris B Martin, Jacqueline A Sullivan, Jessey Wright, Stefan Köhler
A role of perirhinal cortex (PrC) in recognition memory for objects has been well established. Contributions of parahippocampal cortex (PhC) to this function, while documented, remain less well understood. Here, we used fMRI to examine whether the organization of item-based recognition memory signals across these two structures is shaped by object category, independent of any difference in representing episodic context. Guided by research suggesting that PhC plays a critical role in processing landmarks, we focused on three categories of objects that differ from each other in their landmark suitability as confirmed with behavioral ratings (buildings > trees > aircraft)...
November 3, 2017: NeuroImage
https://www.readbyqxmd.com/read/29099624/pelvic-restraint-cushion-sled-test-evaluation-of-pelvic-forward-motion
#12
Greg Shaw, David Lessley, Joseph Ash, Salvador Acosta, Sara Heltzel, Patrick Riley, Taewung Kim, Jeff Crandall
OBJECTIVE: This study was designed to evaluate the performance of a pelvic restraint cushion (PRC), a submarining countermeasure that deploys under the thighs when a crash is detected in order to block the forward motion of the pelvis. METHODS: Sled tests approximating low and high speed frontal impacts were conducted with four PMHS female subjects restrained by a lap and shoulder belt in the right front passenger seat. The subjects were tested with and without a PRC...
November 3, 2017: Traffic Injury Prevention
https://www.readbyqxmd.com/read/29090639/platelet-rich-concentrate-in-serum-free-medium-enhances-cartilage-specific-extracellular-matrix-synthesis-and-reduces-chondrocyte-hypertrophy-of-human-mesenchymal-stromal-cells-encapsulated-in-alginate
#13
Shani Samuel, Raja Elina Ahmad, Thamil Selvee Ramasamy, Puvanan Karunanithi, Sangeetha Vasudevaraj Naveen, Tunku Kamarul
Platelet-rich concentrate (PRC), used in conjunction with other chondroinductive growth factors, have been shown to induce chondrogenesis of human mesenchymal stromal cells (hMSC) in pellet culture. However, pellet culture systems promote cell hypertrophy and the presence of other chondroinductive growth factors in the culture media used in previous studies obscures accurate determination of the effect of platelet itself in inducing chondrogenic differentiation. Hence, this study aimed to investigate the effect of PRC alone in enhancing the chondrogenic differentiation potential of human mesenchymal stromal cells (hMSC) encapsulated in three-dimensional alginate constructs...
November 1, 2017: Platelets
https://www.readbyqxmd.com/read/29079024/low-grade-blunt-hepatic-injury-and-benefits-of-intensive-care-unit-monitoring
#14
Jeffrey C Perumean, Marco Martinez, Rachel Neal, James Lee, Taofeek Olajire-Aro, Jon B Imran, Brian H Williams, Herb A Phelan
BACKGROUND: We investigated low-grade, hemodynamically normal BHI associated with any of three interventions indicating ICU observation. METHODS: BHI between 01/01/96-6/30/14 were reviewed. Two groups included: Group A (BHI grades 1-3) with normal initial systolic BP and Group B (all other BHI). Interventions necessitating ICU observation were defined with three criteria: PRC transfusion within 24 h, angiography, or laparotomy. Between group and Group A subgroup outcomes were reported...
September 18, 2017: American Journal of Surgery
https://www.readbyqxmd.com/read/29073645/integration-of-objects-and-space-in-perception-and-memory
#15
REVIEW
Charles E Connor, James J Knierim
Distinct processing of objects and space has been an organizing principle for studying higher-level vision and medial temporal lobe memory. Here, however, we discuss how object and spatial information are in fact closely integrated in vision and memory. The ventral, object-processing visual pathway carries precise spatial information, transformed from retinotopic coordinates into relative dimensions. At the final stages of the ventral pathway, including the dorsal anterior temporal lobe (TEd), object-sensitive neurons are intermixed with neurons that process large-scale environmental space...
October 26, 2017: Nature Neuroscience
https://www.readbyqxmd.com/read/29059090/aldosterone-to-renin-ratio-depends-on-age-and-sex-in-children-attending-a-clinic-for-cardiovascular-risk-assessment
#16
Simonetta Genovesi, Laura Antolini, Antonina Orlando, Elena Tassistro, Marco Giussani, Elisa Nava, Lucia Turolo, Jenny Manolopoulou, Gianfranco Parati, Alberto Morganti
OBJECTIVE: To determine plasma aldosterone concentration (PAC) and plasma renin concentration (PRC) and aldosterone-to-renin ratio (ARR) values in a population attending a Clinic for Cardiovascular Risk Assessment in Children. METHODS: We assessed ARR and associated factors in a cohort of 287 children (137 female, 4-18 years). Weight and blood pressure (BP) were recorded. PAC (ng/dl) and PRC (mU/l) were measured using direct immunochemiluminescent assays. Data were examined by sex and according to four age classes...
October 20, 2017: Journal of Hypertension
https://www.readbyqxmd.com/read/29056625/the-development-of-a-community-engagement-workshop-a-community-led-approach-for-building-researcher-capacity
#17
Jake Coffey, Anna Huff-Davis, Christie Lindsey, Onie Norman, Henryetter Curtis, Calvin Criner, M Kathryn Stewart
BACKGROUND: Although community-engaged research (CEnR) is increasingly promoted in the literature, academic programs often fail to prepare researchers for the critical, ethical, and power issues involved in CEnR. This article documents a community-created and led workshop for CEnR researchers. OBJECTIVES: The workshop's main objective is to increase researchers' knowledge and felt experience of the "dos and don'ts" of CEnR in three research domains: entering the community, accommodating the realities and constraints of community-based organizations, and dissemination...
2017: Progress in Community Health Partnerships: Research, Education, and Action
https://www.readbyqxmd.com/read/29050713/is-preoperative-fibrinogen-testing-associated-with-total-blood-loss-in-adolescent-idiopathic-scoliosis-correction
#18
Matthew J Geck, Devender Singh, Holly Gunn, John K Stokes, Eeric Truumees
STUDY DESIGN: Retrospective analysis. OBJECTIVE: This study sought to investigate the potential association between preoperative fibrinogen, bleeding, and transfusion requirements in adolescent idiopathic scoliosis (AIS) corrections. SUMMARY OF BACKGROUND DATA: Blood loss after major spinal reconstruction increases the risks and costs of surgery. Preoperative fibrinogen levels may predict intra- and postoperative blood loss. METHODS: Data were collected from clinic charts and hospital medical records of all 110 of a single surgeon's consecutive AIS patients undergoing greater than three-level deformity correction surgeries from January 2011 to December 2013...
November 2017: Spine Deformity
https://www.readbyqxmd.com/read/29025841/neighbourhood-characteristics-and-mental-disorders-in-three-chinese-cities-multilevel-models-from-the-world-mental-health-surveys
#19
Alexandre Dias Porto Chiavegatto Filho, Laura Sampson, Silvia S Martins, Shui Yu, Yueqin Huang, Yanling He, Sing Lee, Chiyi Hu, Alan Zaslavsky, Ronald C Kessler, Sandro Galea
OBJECTIVES: The rapid growth of urban areas in China in the past few decades has introduced profound changes in family structure and income distribution that could plausibly affect mental health. Although multilevel studies of the influence of area-level socioeconomic factors on mental health have become more common in other parts of the world, a study of this sort has not been carried out in Chinese cities. Our objectives were to examine the associations of two key neighbourhood-level variables-median income and percentage of married individuals living in the neighbourhood-with mental disorders net of individual-level income and marital status in three Chinese cities...
October 11, 2017: BMJ Open
https://www.readbyqxmd.com/read/28988385/adapting-current-model-with-field-data-of-related-performance-reference-compounds-in-passive-samplers-to-accurately-monitor-hydrophobic-organic-compounds-in-aqueous-media
#20
Pokem Temoka, Gerd Pfister, Bernhard Henkelmann, Karl-Werner Schramm
Performance reference compounds (PRCs) are neutral organic compounds, introduced in a passive sampler prior deployment for the assessment of in situ sampling rate. In this study, evaluation of in situ sampling rates of 16 (13)C-PAH-PRCs with moderate and high hydrophobicity was established to provide an overall correction factor for variations in virtual organism (VO) uptake rates of the analytes of interest. In situ sampling rate was compared to an empirical model during sampling campaign in 2011 with VO in 12 different sites along the Three Gorges Reservoir (TGR) in China...
October 7, 2017: Environmental Monitoring and Assessment
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