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https://www.readbyqxmd.com/read/29333332/next-generation-tissue-engineering-of-orthopedic-soft-tissue-to-bone-interfaces
#1
Alexander J Boys, Mary Clare McCorry, Scott Rodeo, Lawrence J Bonassar, Lara A Estroff
Soft tissue-to-bone interfaces are complex structures that consist of gradients of extracellular matrix materials, cell phenotypes, and biochemical signals. These interfaces, called entheses for ligaments, tendons, and the meniscus, are crucial to joint function, transferring mechanical loads and stabilizing orthopedic joints. When injuries occur to connected soft tissue, the enthesis must be re-established to restore function, but due to structural complexity, repair has proven challenging. Tissue engineering offers a promising solution for regenerating these tissues...
September 2017: MRS Communications
https://www.readbyqxmd.com/read/29331290/the-use-of-ultrasonography-to-identify-the-intersection-of-the-dorsomedial-cutaneous-nerve-of-the-hallux-and-the-extensor-hallucis-longus-tendon-a-cadaveric-study
#2
Matthew J Zdilla, Kyle D Miller, Jordan V Swearingen, H Wayne Lambert
Terminal branches of the superficial fibular nerve are at risk of iatrogenic damage during foot surgery, including hallux valgus rigidus correction, bunionectomy, cheilectomy, and extensor hallucis longus tendon transfer. One terminal branch, the dorsomedial cutaneous nerve of the hallux, is particularly at risk of injury at its intersection with the extensor hallucis longus tendon. Iatrogenic injuries of the dorsomedial cutaneous nerve of the hallux can result in sensory loss, neuroma formation, and/or debilitating causalgia...
January 11, 2018: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/29330711/boosting-tendon-repair-interplay-of-cells-growth-factors-and-scaffold-free-and-gel-based-carriers
#3
REVIEW
Zexing Yan, Heyong Yin, Michael Nerlich, Christian G Pfeifer, Denitsa Docheva
BACKGROUND: Tendons are dense connective tissues and critical components for the integrity and function of the musculoskeletal system. Tendons connect bone to muscle and transmit forces on which locomotion entirely depends. Due to trauma, overuse and age-related degeneration, many people suffer from acute or chronic tendon injuries. Owing to their hypovascularity and hypocellularity, tendinopathies remain a substantial challenge for both clinicians and researchers. Surgical treatment includes suture or transplantation of autograft, allograft or xenograft, and these serve as the most common technique for rescuing tendon injuries...
January 5, 2018: Journal of Experimental Orthopaedics
https://www.readbyqxmd.com/read/29327128/isolated-avulsion-fracture-of-the-first-metatarsal-base-at-the-peroneus-longus-tendon-attachment-a-case-report
#4
Maxwell W Weinberg, Nicola Krähenbühl, Nathan P Davidson, Christopher J Hanrahan, Alexej Barg
Avulsion fractures of the first metatarsal (MT1) base at the peroneus longus (PL) tendon attachment are rare and may be undiagnosed during an emergency visit. If the injury is not treated properly, chronic pain or persistent impairment for inversion and plantar-flexion of the first ray may occur. This case report presents a 30-year-old woman who presented 10 weeks post trauma to a foot and ankle surgeon due to a swollen right midfoot with diffuse tenderness over the medial Lisfranc joint. Further evaluation showed an isolated avulsion fracture of the first metatarsal, which was undiagnosed during the emergent visit following the accident...
January 11, 2018: Skeletal Radiology
https://www.readbyqxmd.com/read/29324409/assessment-of-spasticity-by-a-pendulum-test-in-sci-patients-who-exercise-fes-cycling-or-receive-only-conventional-therapy
#5
Lana Popovic-Maneski, Antonina Aleksic, Amine Metani, Vance Bergeron, Radoje Cobeljic, Dejan B Popovic
Increased muscle tone and exaggerated tendon reflexes characterize most of the individuals after a spinal cord injury (SCI). We estimated seven parameters from the pendulum test and used them to compare with the Ashworth modified scale of spasticity grades in three populations (retrospective study) to assess their spasticity. Three ASIA B SCI patients who exercised on a stationary FES bicycle formed group F, six ASIA B SCI patients who received only conventional therapy were in the group C, and six healthy individuals constituted the group H...
January 2018: IEEE Transactions on Neural Systems and Rehabilitation Engineering
https://www.readbyqxmd.com/read/29323533/comparison-of-repair-characteristics-of-artificial-dermis-composite-tissue-with-traditional-prefabricated-flap
#6
Yuchong Wang, Mengyan Sun, Haiying Dai, Chuan Lv, Jianguo Xu, Ji Zhu, Ran Tao, Kai Wu, Xinwei Wang, Chunyu Xue
BACKGROUND: We compared the application of artificial dermis composite tissue and the traditional prefabricated flap in a rat model of an exposed bone and tendon injury. METHODS: Sprague Dawley rats were randomly divided into two groups (A and B, n = 40). Group A rats received artificial dermis composite tissue flaps while group B rats received traditional prefabricated flaps. Flap appearance, range of motion, degree of swelling, tissue histology, and imaging were compared between groups at 7, 14, 21, and 28 days...
January 11, 2018: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/29318178/outcomes-after-dermal-allograft-reconstruction-of-chronic-or-subacute-pectoralis-major-tendon-ruptures
#7
Julie A Neumann, Christopher M Klein, Carola F van Eck, Hithem Rahmi, John M Itamura
Background: Avoiding delay in the surgical management of pectoralis major (PM) ruptures optimizes outcomes. However, this is not always possible, and when a tear becomes chronic or when a subacute tear has poor tissue quality, a graft can facilitate reconstruction. Purpose: The primary aim was to evaluate the clinical outcomes of PM reconstruction with dermal allograft augmentation for chronic tears or for subacute tears with poor tissue quality. A second aim was to determine patient and surgical factors affecting outcome...
January 2018: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/29317260/growth-factor-delivery-strategies-for-rotator-cuff-repair-and-regeneration
#8
Anupama Prabhath, Varadraj N Vernekar, Enid Sanchez, Cato T Laurencin
The high incidence of degenerative tears and prevalence of retears (20-95%) after surgical repair makes rotator cuff injuries a significant health problem. This high retear rate is attributed to the failure of the repaired tissue to regenerate the native tendon-to-bone insertion (enthesis). Biological augmentation of surgical repair such as autografts, allografts, and xenografts are confounded by donor site morbidity, immunogenicity, and disease transmission, respectively. In contrast, these risks may be alleviated via growth factor therapy, which can actively influence the healing environment to promote functional repair...
January 6, 2018: International Journal of Pharmaceutics
https://www.readbyqxmd.com/read/29315990/activation-of-akt-mtor-signaling-directs-tenogenesis-of-mesenchymal-stem-cells
#9
Xiao Xia Cong, Xi Sheng Rao, Jun Xin Lin, Xiao Ceng Liu, Guang An Zhang, Xiu Kui Gao, Min Yi He, Wei Liang Shen, Wei Fan, Dominique Pioletti, Li Ling Zheng, Huan Huan Liu, Zi Yin, Boon Chuan Low, Ronen Schweitzer, Hongwei Ouyang, Xiao Chen, Yi Ting Zhou
Tendon repair is a clinical challenge because of the limited understanding on tenogenesis. The synthesis of type I collagen (Collagen I) and other extracellular matrix are essential for tendon differentiation and homeostasis. Current studies on tenogenesis focused mostly on the tenogenic transcriptional factors while the signaling controlling tenogenesis on translational level remains largely unknown. Here, we showed that mechanistic target of rapamycin (mTOR) signaling was activated by protenogenic growth factor, transforming growth factors beta1, and insulin-like growth factor-I...
January 4, 2018: Stem Cells
https://www.readbyqxmd.com/read/29312850/anterolateral-rotatory-instability-in-vivo-correlates-tunnel-position-after-anterior-cruciate-ligament-reconstruction-using-bone-patellar-tendon-bone-graft
#10
Yasutaka Tashiro, Ken Okazaki, Koji Murakami, Hirokazu Matsubara, Kanji Osaki, Yukihide Iwamoto, Yasuharu Nakashima
AIM: To quantitatively assess rotatory and anterior-posterior instability in vivo after anterior cruciate ligament (ACL) reconstruction using bone-patellar tendon-bone (BTB) autografts, and to clarify the influence of tunnel positions on the knee stability. METHODS: Single-bundle ACL reconstruction with BTB autograft was performed on 50 patients with a mean age of 28 years using the trans-tibial (TT) (n = 20) and trans-portal (TP) (n = 30) techniques. Femoral and tibial tunnel positions were identified from the high-resolution 3D-CT bone models two weeks after surgery...
December 18, 2017: World Journal of Orthopedics
https://www.readbyqxmd.com/read/29305621/-modern-treatment-strategies-for-the-long-head-of-the-biceps-tendon
#11
REVIEW
S Braun, A B Imhoff
The long head of the biceps and the biceps pulley sling are prone to acute or degenerative injury. As they both were identified as major pain generators, adequate diagnosis and treatment is vital for successful treatment of shoulder pain. Although the basic principles to address either pathology have not changed over the last decades, new trends have evolved to simplify surgical options. SLAP (superior labral tear from anterior to posterior) repair is seen more restrictive and is mostly performed in young individuals, whereas tenotomy or tenodesis are more often used in patients over 30...
January 5, 2018: Der Orthopäde
https://www.readbyqxmd.com/read/29304958/editorial-commentary-proximal-hamstring-syndrome-another-pain-in-the-buttock
#12
EDITORIAL
Dean K Matsuda
Proximal hamstring injuries cause buttock pain and may result in significant weakness and sciatic neuralgia. Avulsion ruptures involving 2 or more tendons with >2-cm retraction may benefit from early open surgical repair. More chronic equivalents may benefit from Achilles allograft reconstruction. Chronic proximal hamstring syndrome causing posterior thigh and sit pain may occur from less severe, often repetitive injury to the proximal hamstring origin with secondary sciatic neuralgia from local adhesions or scar entrapment...
January 2018: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29303923/flexor-tendon-injuries
#13
Christopher S Klifto, John T Capo, Anthony Sapienza, S Steven Yang, Nader Paksima
Flexor tendon injuries of the hand are uncommon, and they are among the most challenging orthopaedic injuries to manage. Proper management is essential to ensure optimal outcomes. Consistent, successful management of flexor tendon injuries relies on understanding the anatomy, characteristics and repair of tendons in the different zones, potential complications, rehabilitation protocols, recent advances in treatment, and future directions, including tissue engineering and biologic modification of the repair site...
January 15, 2018: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/29302136/in-vitro-comparison-of-two-barbed-suture-configurations-for-flexor-tendon-repair
#14
Jamie L Engel, Joseph N Gabra, Andrew R Esterle, William D Lanzinger, John J Elias
Purpose  The current study compares the strength of a previously studied technique for flexor tendon repair with barbed sutures to an experimental approach that aligns all the barbs to oppose distraction. Methods  Twelve flexor tendons from cadaveric specimens were mechanically tested following repair of simulated zone II tendon injuries. Two repair techniques utilizing barbed sutures were studied: the Marrero-Amadeo four-core barbed suture approach and the experimental configuration with all barbs on four cores opposing distraction...
December 2017: Journal of Hand and Microsurgery
https://www.readbyqxmd.com/read/29298454/risk-factors-for-contralateral-acl-injury-a-single-institution-case-control-study
#15
Todd P Pierce, Kimona Issa, Kaitlin Cassidy, Anthony Festa, Vincent K McInerney, Anthony J Scillia
Our purpose was to evaluate if there is any association between requiring contralateral anterior cruciate ligament (ACL) reconstruction and various: (1) demographics, (2) patient characteristics, and (3) surgery-specific factors. A prospectively collected database at a single institution was queried to find all patients who underwent primary ACL reconstruction between 2012 and 2014. We identified 312 primary ACL reconstruction patients with a mean age of 24 years and a mean follow-up of 3 years (range, 2-5 years)...
January 3, 2018: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29298161/the-evolving-treatment-patterns-of-ncaa-division-i-football-players-by-orthopaedic-team-physicians-over-the-past-decade-2008-2016
#16
Trevor J Carver, John B Schrock, Matthew J Kraeutler, Eric C McCarty
BACKGROUND: Previous studies have analyzed the treatment patterns used to manage injuries in National Collegiate Athletic Association (NCAA) Division I football players. HYPOTHESIS: Treatment patterns used to manage injuries in NCAA Division I football players will have changed over the study period. STUDY DESIGN: Descriptive epidemiology study. LEVEL OF EVIDENCE: Level 5. METHODS: The head orthopaedic team physicians for all 128 NCAA Division I football teams were asked to complete a survey containing questions regarding experience as team physician, medical coverage of the team, reimbursement issues, and treatment preferences for some of the most common injuries occurring in football players...
January 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29287949/comparison-of-clinical-outcomes-after-anterior-cruciate-ligament-reconstruction-using-a-hybrid-graft-versus-a-hamstring-autograft
#17
Hong-De Wang, Shi-Jun Gao, Ying-Ze Zhang
PURPOSE: This study aimed to compare the clinical outcomes of patients who underwent anterior cruciate ligament (ACL) reconstruction with a hybrid graft versus an autograft after 3 years of follow-up. METHODS: Among 57 patients with an ACL injury who underwent ACL reconstruction, 28 patients received a hybrid graft (gracilis and semitendinosus tendon autograft plus a soft tissue allograft) and 29 patients received an autograft (gracilis and semitendinosus tendon autograft)...
December 26, 2017: Arthroscopy: the Journal of Arthroscopic & related Surgery
https://www.readbyqxmd.com/read/29284176/bone-patellar-tendon-bone-autograft-versus-hamstring-tendon-autograft-for-anatomical-anterior-cruciate-ligament-reconstruction-with-three-dimensional-validation-of-femoral-and-tibial-tunnel-positions
#18
Shuji Taketomi, Hiroshi Inui, Ryota Yamagami, Nobuyuki Shirakawa, Kohei Kawaguchi, Takumi Nakagawa, Sakae Tanaka
The purpose of this retrospective study was to first compare the clinical outcome of anatomical double-bundle (DB) anterior cruciate ligament reconstruction (ACLR) with hamstring tendon (HT) autografts and anatomical rectangular tunnel ACLR with bone-patellar tendon-bone (BPTB) autografts. Secondly, we aimed to demonstrate the quantitative locations of the femoral and tibial tunnel apertures using postoperative three-dimensional computed tomography (3D CT).Twenty-five patients underwent anatomical rectangular tunnel ACLR using BPTB grafts (Group B) and 23 patients underwent anatomical DB ACLR using HT grafts (Group H)...
December 28, 2017: Journal of Knee Surgery
https://www.readbyqxmd.com/read/29282488/outcome-of-surgery-for-nerve-injury-following-total-hip-arthroplasty
#19
James W Pritchett
PURPOSE: During hip replacement, nerves in the operative field can be injured accidently. Additional surgical procedures can help restore function and reduce pain if there has been no recovery. METHODS: One-hundred sixty-two patients presented with nerve injuries, and 113 were candidates for surgical treatment. The author performed 91 procedures on the injured limb (80 patients; 11 had 2 procedures) consisting of shortening, sympathectomy, tendon transfer, neurolysis or nerve repair/graft and 30 spinal and three fibular-neck decompressions...
December 28, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/29278683/rescue-plan-for-achilles-therapeutics-steering-the-fate-and-functions-of-stem-cells-in-tendon-wound-healing
#20
Magdalena Schneider, Peter Angele, Tero A H Järvinen, Denitsa Docheva
Due to the increasing age of our society and a rise in engagement of young people in extreme and/or competitive sports, both tendinopathies and tendon ruptures present a clinical and financial challenge. Tendon has limited natural healing capacity and often responds poorly to treatments, hence it requires prolonged rehabilitation in most cases. Till today, none of the therapeutic options has provided successful long-term solutions, meaning that repaired tendons do not recover their complete strength and functionality...
December 23, 2017: Advanced Drug Delivery Reviews
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