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https://www.readbyqxmd.com/read/28937836/optimizing-a-3d-model-system-for-molecular-manipulation-of-tenogenesis
#1
Chun Chien, Brian Pryce, Sara F Tufa, Douglas R Keene, Alice H Huang
PURPOSE: Tendon injuries are clinically challenging due to poor healing. A better understanding of the molecular events that regulate tendon differentiation would improve current strategies for repair. The mouse model system has been instrumental to tendon studies and several key molecules were initially established in mouse. However, the study of gene function has been limited by the absence of a standard in vitro tendon system for efficiently testing multiple mutations, physical manipulations, and mis-expression...
September 22, 2017: Connective Tissue Research
https://www.readbyqxmd.com/read/28933198/iatrogenic-injuries-in-percutaneous-pinning-techniques-for-fifth-metacarpal-neck-fractures
#2
Sheriff D Akinleye, Garret Garofolo-Gonzalez, Maya Deza Culbertson, Jack Choueka
BACKGROUND: There is little information regarding anatomic structures at risk during closed percutaneous treatment of fifth metacarpal neck fractures. This study evaluates a variety of common percutaneous techniques with the hypothesis that each approach presents unique risks to tendons and neurovascular structures. METHODS: Seven cadaveric hands were used for this study. The senior author, a board-certified hand surgeon with more than 20 years of experience, used a mini-C arm to pass 1...
September 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28927769/spontaneous-healing-of-a-tear-of-an-anterior-cruciate-ligament-graft-a-case-report
#3
Natalie Yu Yi Ng, Barry Wei Loong Tan, Lingaraj Krishna
BACKGROUND: Almost 30% of young athletic patients sustain a second anterior cruciate ligament (ACL) injury within 24months of their ACL reconstruction and returning to pivoting sports. Most patients with high athletic demand and significant anteroposterior instability often require ACL revision surgery to restore their pre-injury activity levels. CASE REPORT: A 24-year old gentleman ruptured his hamstring tendon autograft during a twisting injury seven months after his ACL reconstruction...
September 16, 2017: Knee
https://www.readbyqxmd.com/read/28922015/over-the-top-acl-reconstruction-plus-extra-articular-lateral-tenodesis-with-hamstring-tendon-grafts-prospective-evaluation-with-20-year-minimum-follow-up
#4
Stefano Zaffagnini, Giulio Maria Marcheggiani Muccioli, Alberto Grassi, Tommaso Roberti di Sarsina, Federico Raggi, Cecilia Signorelli, Francisco Urrizola, Paolo Spinnato, Eugenio Rimondi, Maurilio Marcacci
BACKGROUND: There are few published studies with very long-term follow-up of combined intra- and extra-articular anterior cruciate ligament (ACL) reconstruction. PURPOSE: To analyze clinical and radiographic outcomes of over-the-top ACL reconstruction plus extra-articular lateral tenodesis with autologous hamstrings at minimum 20-year follow-up. STUDY DESIGN: Case series; Level of evidence, 4. METHODS: Of 60 originally eligible patients who underwent over-the-top ACL reconstruction with double-stranded hamstring tendon (leaving intact graft tibial insertions) and extra-articular lateral plasty (performed with the remnant part of tendons), 52 were prospectively evaluated at a minimum 20-year follow-up (mean follow-up, 24 years; 41 men, 11 women; mean age at time of surgery, 25...
September 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28920544/identification-of-the-location-of-the-a1-pulley-combining-palpation-technique-with-palm-landmarks-and-percutaneous-release-of-a1-pulley-with-a-19-gauge-needle-a-cadaveric-study
#5
Aleksandr Grinčuk, Karolis Baužys, Narūnas Porvaneckas, Valentinas Uvarovas, Gediminas Rauba, Sigitas Ryliškis
The aims of this study were to identify the location of the A1 pulley combining palpation technique with superficial palm landmarks and to determine the efficacy and safety of A1 pulley percutaneous release with a 19-gauge needle. Fourteen fresh frozen cadaveric specimens were used: 56 fingers and 14 thumbs. The location of the A1 pulley was based on anatomical landmarks and was identified in all digits. Complete release of the A1 pulley occurred in 60 of the 70 digits (85.7%). The length of the A1 pulley in thumbs was 5...
September 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/28920487/unilateral-dislocation-of-the-posterior-tibialis-tendon-ptt-and-flexor-digitorum-longus-tendon-with-contralateral-ptt-subluxation-in-a-patient-with-congenitally-shallow-flexor-groove
#6
Jacob E Waldron, Andrew S Bernhardson, Todd A Fellars
INTRODUCTION: Flexor tendon dislocation from the flexor tendon groove posterior of the medial malleolus has been previously described, and may be difficult to diagnose initially, but is amendable to surgical treatment with good outcomes. We present a unique case of unilateral dislocation of the posterior tibialis and flexor digitorum longus tendons with contralateral flexor digitorum longus subluxation that was treated surgically with a good outcome. CASE PRESENTATION: A 37-year-old active duty male sustained a dislocation and subluxation of the flexor tendons bilaterally after a forced dorsiflexion injury...
October 2017: Foot & Ankle Specialist
https://www.readbyqxmd.com/read/28919608/arthroscopic-anterior-cruciate-ligament-reconstruction-with-triplet-autograft-of-semitendinosus-tendon
#7
M Z Islam, M Rahman, M E Ali, M K Alam, W Ahmed, M T Alam, M K Saha
Anterior cruciate ligament (ACL) is the most commonly injured ligament occurs in young adult population, which markedly reduces activity level. Anterior cruciate ligament rupture is a threat to the homeostasis of the knee. So, reconstruction of the ACL is necessary to make them fit and return to their pre-injury activity level. The choice of graft for ACL reconstruction is a matter of debate, with the BPTB graft and quadruple graft of ST-G being the two most popular options. Use of triplet graft of semi-tendinosus tendon alone without sacrificing gracilis is another option...
July 2017: Mymensingh Medical Journal: MMJ
https://www.readbyqxmd.com/read/28919507/tissue-engineered-magnetic-cell-sheet-patches-for-advanced-strategies-in-tendon-regeneration
#8
Ana I Gonçalves, Márcia T Rodrigues, Manuela E Gomes
Tendons are powerful 3D biomechanically structures combining a few cells in an intrincated and highly hierarchical niche environment. When tendon homeostasis is compromised, restoration of functionality upon injury is limited and requires alternatives to current augmentation or replacement strategies. Cell sheet technologies are a powerful tool for the fabrication of living extracellular-rich patches towards regeneration of tenotopic defects. Thus, we originally propose the development of magnetically responsive tenogenic patches through magnetic cell sheet (magCSs) technology that enable the remote control upon implantation of the tendon-mimicking constructs...
September 14, 2017: Acta Biomaterialia
https://www.readbyqxmd.com/read/28919185/epidemiology-of-cervical-spine-injuries-in-high-school-athletes-over-a-ten-year-period
#9
Adele Meron, Christopher McMullen, Scott R Laker, Dustin Currie, R Dawn Comstock
BACKGROUND: Over 7 million athletes participate in high school (HS) sports annually, with both the benefits of physical activity and risks of injury. While catastrophic cervical spine injuries have been studied, limited data are available characterizing less severe cervical spine injuries in HS athletes. OBJECTIVE: To describe and compare cervical spine injury rates and patterns among United States (US) HS athletes across 24 sports over a ten-year period. DESIGN: Descriptive epidemiology study SETTING: National sample of high schools participating in the High School Reporting Information Online (High School RIO) injury surveillance system...
September 12, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28916837/primary-and-secondary-consequences-of-rotator-cuff-injury-on-joint-stabilizing-tissues-in-the-shoulder
#10
Hafizur Rahman, Eric Currier, Marshall Johnson, Rick Goding, Amy J Wagoner Johnson, Mariana Kersh
Rotator cuff tears are one of the primary causes of shoulder pain and dysfunction in the upper extremity accounting over 4.5 million physician visits per year with 250,000 rotator cuff repairs being performed annually in the United States. While the tear is often considered an injury to a specific tendon/tendons and consequently treated as such, there are secondary effects of rotator cuff tears that may have significant consequences for shoulder function. Specifically, rotator cuff tears have been shown to affect the joint cartilage, bone, the ligaments, as well as the remaining intact tendons of the shoulder joint...
September 16, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28916692/does-tendon-firing-quicken-time-to-recovery-for-superficial-digital-flexor-tendon-injury
#11
(no author information available yet)
No abstract text is available yet for this article.
September 16, 2017: Veterinary Record
https://www.readbyqxmd.com/read/28906300/isolated-dorsoradial-capsular-tear-of-the-thumb-metacarpophalangeal-joint-missed-diagnosis-and-the-management-of-delayed-presentation
#12
Yvette Godwin, Britt Ter Horst, Godwin Scerri
Isolated dorsoradial capsule injuries of the thumb metacarpophalangeal joint are different from those associated with collateral ligament disruption. Early suspicion of this rare injury is important because, if overlooked, ulnarward subluxation of extensor pollicis longus tendon can develop. Functionally, active thumb extension becomes impaired, and over the long term, a thumb Boutonniere's deformity becomes established. Joint hypermobility/instability may predispose to this injury. The 2 cases presented illustrate this through anatomic differences...
September 12, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/28905242/poly-n-acetyl-glucosamine-snag-enhances-early-rotator-cuff-tendon-healing-in-a-rat-model
#13
C A Nuss, J Huegel, J F Boorman-Padgett, D S Choi, S N Weiss, J Vournakis, L J Soslowsky
Rotator cuff injuries frequently require surgical repairs which have a high failure rate. Biological augmentation has been utilized in an attempt to improve tendon repair. Poly-N-acetyl glucosamine (sNAG) polymer containing nanofibers has been shown to increase the rate for healing of venous leg ulcers. The purpose of this study was to investigate the healing and analgesic properties of sNAG in a rat rotator cuff injury and repair model. 144 adult male Sprague-Dawley rats underwent a transection and repair of their left supraspinatus tendons...
September 13, 2017: Annals of Biomedical Engineering
https://www.readbyqxmd.com/read/28903949/intramuscular-tendon-involvement-on-mri-has-limited-value-for-predicting-time-to-return-to-play-following-acute-hamstring-injury
#14
Anne D van der Made, Emad Almusa, Rod Whiteley, Bruce Hamilton, Cristiano Eirale, Frank van Hellemondt, Johannes L Tol
BACKGROUND: Hamstring injury with intramuscular tendon involvement is regarded as a serious injury with a delay in return to play (RTP) of more than 50 days and reinjury rates up to 63%. However, this reputation is based on retrospective case series with high risk of bias. OBJECTIVE: Determine whether intramuscular tendon involvement is associated with delayed RTP and elevated rates of reinjury. METHODS: MRI of male athletes with an acute hamstring injury was obtained within 5 days of injury...
September 13, 2017: British Journal of Sports Medicine
https://www.readbyqxmd.com/read/28902861/epigenetic-regulation-of-metalloproteinases-and-their-inhibitors-in-rotator-cuff-tears
#15
Mariana Ferreira Leal, Leonardo Caires Dos Santos, Adrielle Martins de Oliveira, Paulo Santoro Belangero, Eduardo Antônio Figueiredo, Carina Cohen, Felipe de Seixas Alves, Wânia Hiromi Yanaguizawa, Carlos Vicente Andreoli, Alberto de Castro Pochini, Benno Ejnisman, Marília Cardoso Smith, Maria Teresa de Seixas Alves, Moises Cohen
Rotator cuff tear is a common orthopedic condition. Metalloproteinases (MMP) and their inhibitors (TIMP) seem to play a role in the development of joint injuries and in the failure of tissue healing. However, the mechanisms of regulation of gene expression in tendons are still unknown. Epigenetic mechanisms, such as DNA methylation and microRNAs regulation, are involved in the dynamic control of gene expression. Here, the mRNA expression and DNA methylation status of MMPs (MMP1, MMP2, MMP3, MMP9, MMP13, and MMP14) and TIMPs (TIMP1-3) and the expression of miR-29 family members in ruptured supraspinatus tendons were compared with non-injured tendons of individuals without this lesion...
2017: PloS One
https://www.readbyqxmd.com/read/28901963/underlying-chronic-disease-medication-use-history-of-running-injuries-and-being-a-more-experienced-runner-are-independent-factors-associated-with-exercise-associated-muscle-cramping-a-cross-sectional-study-in-15778-distance-runners
#16
Martin P Schwellnus, Sonja Swanevelder, Esme Jordaan, Wayne Derman, Dina C Janse Van Rensburg
BACKGROUND: Exercise-associated muscle cramping (EAMC) is a significant medical complication in distance runners, yet factors associated with EAMC are poorly documented. OBJECTIVE: To document risk factors associated with EAMC in runners. DESIGN: Cross-sectional study. SETTING: Two ocean races (21.1 km, and 56 km). PARTICIPANTS: Fifteen thousand seven hundred seventy-eight race entrants. METHODS: Participants completed a prerace medical history screening tool including: training, cardiovascular disease (CVD), risk factors for, and symptoms of CVD, history of diseases affecting major organ systems, cancer, allergies, medication use, and running injury...
August 18, 2017: Clinical Journal of Sport Medicine: Official Journal of the Canadian Academy of Sport Medicine
https://www.readbyqxmd.com/read/28899880/effects-of-aging-and-resistance-training-in-rat-tendon-remodeling
#17
Rita C Marqueti, João L Q Durigan, Anderson José S Oliveira, Marcelo Shinyu Mekaro, Vinicius Guzzoni, Andrea A Aro, Edson Rosa Pimentel, Heloisa S Selistre-de-Araujo
In elderly persons, weak tendons contribute to functional limitations, injuries, and disability, but resistance training can attenuate this age-related decline. We evaluated the effects of resistance training on the extracellular matrix (ECM) of the calcaneal tendon (CT) in young and old rats and its effect on tendon remodeling. Wistar rats aged 3 mo (young, n = 30) and 20 mo (old, n = 30) were divided into 4 groups: young sedentary, young trained, old sedentary (OS), and old trained (OT). The training sessions were conducted over a 12-wk period...
September 12, 2017: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://www.readbyqxmd.com/read/28894676/meta-analysis-of-long-thoracic-nerve-decompression-and-neurolysis-versus-muscle-and-tendon-transfer-operative-treatments-of-winging-scapula
#18
Rahul K Nath, Chandra Somasundaram
BACKGROUND: Injury to long thoracic and the spinal accessory nerves can cause winging scapula as a result of weakness and paralysis of the trapezius and serratus anterior muscles. Although these nerve and muscle operations have been reported to correct winging scapula due to various causes, there is no report on comparing the outcomes of these procedures in peer-reviewed Pubmed-indexed literature. In this article, we compared the improvements in the restoration of shoulder functions in winging scapula patients after long thoracic nerve decompression (LTND) in our present study with outcomes of muscle and tendon transfer operations published in the literature (Aetna cited articles)...
August 2017: Plastic and Reconstructive Surgery. Global Open
https://www.readbyqxmd.com/read/28893394/biceps-tenotomy-in-the-presence-of-a-supraspinatus-tear-alters-the-adjacent-intact-tendons-and-glenoid-cartilage
#19
Zakary M Beach, Jennica J Tucker, Stephen J Thomas, Katherine E Reuther, Chancellor F Gray, Chang-Soo Lee, David L Glaser, Louis J Soslowsky
A rotator cuff tear is a common injury in athletes and workers who repeatedly perform overhead movements, and it is not uncommon for this demographic to return to activity shortly after treatment. A biceps tenotomy is often performed in the presence of a rotator cuff tear to help reduce pain and improve joint function. However, the effect of this procedure on the surrounding tissues in the glenohumeral joint is unknown. Therefore, the purpose of this study was to investigate the effect of a biceps tenotomy in the presence of a supraspinatus rotator cuff tear followed by overuse activity on ambulatory function and mechanical and histologic properties of the remaining rotator cuff tendons and glenoid cartilage...
August 26, 2017: Journal of Biomechanics
https://www.readbyqxmd.com/read/28892648/long-term-outcomes-of-anterior-cruciate-ligament-reconstruction-using-either-synthetics-with-remnant-preservation-or-hamstring-autografts-a-10-year-longitudinal-study
#20
Tianwu Chen, Peng Zhang, Jiwu Chen, Yinghui Hua, Shiyi Chen
BACKGROUND: The optimal graft choice of anterior cruciate ligament (ACL) reconstruction remains controversial. PURPOSE: To compare the outcomes, especially the long-term cumulative failure rate, of ACL reconstruction using either synthetics with remnant preservation or hamstring autografts (4-strand semitendinosus and gracilis tendons). STUDY DESIGN: Cohort study; Level of evidence, 2. METHODS: A total of 133 patients who underwent ACL reconstruction (synthetics: n = 43; hamstring autografts: n = 90) between July 2004 and December 2007 were included...
September 1, 2017: American Journal of Sports Medicine
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