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https://www.readbyqxmd.com/read/28351128/nanoparticles-of-titanium-and-zinc-oxides-as-novel-agents-in-tumor-treatment-a-review
#1
Janusz Bogdan, Joanna Pławińska-Czarnak, Joanna Zarzyńska
Cancer has become a global problem. On all continents, a great number of people are diagnosed with this disease. In spite of the progress in medical care, cancer still ends fatal for a great number of the ill, either as a result of a late diagnosis or due to inefficiency of therapies. The majority of the tumors are resistant to drugs. Thus, the search for new, more effective therapy methods continues. Recently, nanotechnology has been attributed with big expectations in respect of the cancer fight. That interdisciplinary field of science creates nanomaterials (NMs) and nanoparticles (NPs) that can be applied, e...
December 2017: Nanoscale Research Letters
https://www.readbyqxmd.com/read/28351053/macular-edema-rationale-for-therapy
#2
Thomas J Wolfensberger
Macular edema represents the end-stage of multiple pathophysiological pathways in a multitude of ocular vascular, inflammatory, and other diseases. The rationale for clinical treatment of macular edema is based on the understanding and the inhibition of these pathophysiological mechanisms. When macular edema is caused by a generalized health problem such as diabetes, high blood pressure, or generalized inflammatory conditions, treatment of these generalized diseases can in many cases cure macular edema directly...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351041/mechanisms-of-retinal-fluid-accumulation-and-blood-retinal-barrier-breakdown
#3
José Cunha-Vaz
Macular edema is the swelling of the central portion of the human retina and it is associated with increased retinal thickness. It can be simply defined as an excess of fluid within the retinal tissue. It must be realized that the normal retina possesses a functional extracellular space. With regard to the extracellular volume of the retina, there have been few physiologic studies, but there are reported values of 24.8% for the cerebrum and 23.6% for the cerebellum. It is accepted that the retinal extracellular space is similar to the brain...
2017: Developments in Ophthalmology
https://www.readbyqxmd.com/read/28351011/fine-cutting-edge-shaped-bi2o3rods-reduced-graphene-oxide-rgo-composite-for-supercapacitor-and-visible-light-photocatalytic-applications
#4
D Maruthamani, S Vadivel, M Kumaravel, B Saravanakumar, Bappi Paul, Siddhartha Sankar Dhar, Aziz Habibi-Yangjeh, A Manikandan, Govindarajan Ramadoss
Bi2O3 rods/RGO composite has been synthesized by a simple precipitation and calcination method. The crystallnity, structural, and morphological features were studied by X-ray diffraction (XRD), field-emission scanning electron microscopy (FE-SEM), and high resolution transmission electron microscopy (HR-TEM) techniques. The supercapacitor behavior was studied using cyclic voltammetry, galvanostatic charge discharge and impedance analysis, respectively. The Bi2O3 rods/RGO nanocomposite exhibits a maximum specific capacitance of 1041Fg(-1) at a current density of 2Ag(-1)...
March 22, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28351010/vanadium-sulfide-sub-microspheres-a-new-near-infrared-driven-photocatalyst
#5
Yanli Zhou, Pengfei Liu, Fuyi Jiang, Jian Tian, Hongzhi Cui, Jian Yang
Recently, finding a novel near-infrared (NIR) photocatalyst has been the focus in photocatalysis. Here, VS4 sub-microspheres with a chain-like structure were prepared via a facile solvothermal method. As a new photocatalyst, it presents excellent NIR photocatalytic and photoelectrochemical (PEC) activity. Theoretical calculations and experimental results demonstrate that the improved NIR photocatalytic property originated from the narrow band gap of VS4, which significantly improves the NIR light absorption...
March 21, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/28351008/aerosol-characteristics-and-sources-in-yangzhou-china-resolved-by-offline-aerosol-mass-spectrometry-and-other-techniques
#6
Xinlei Ge, Ling Li, Yanfang Chen, Hui Chen, Dan Wu, Junfeng Wang, Xinchun Xie, Shun Ge, Zhaolian Ye, Jianzhong Xu, Mindong Chen
Detailed chemical characterization of fine aerosols (PM2.5) is important for reducing air pollution in densely populated areas, such as the Yangtze River Delta region in China. This study systematically analyzed PM2.5 samples collected during November 2015 to April 2016 in urban Yangzhou using a suite of techniques, in particular, an Aerodyne soot particle aerosol mass spectrometry (SP-AMS). The techniques used here reconstructed the majority of total PM2.5 measured where extracted species comprised on average 91...
March 25, 2017: Environmental Pollution
https://www.readbyqxmd.com/read/28350997/synthesis-and-biological-evaluation-of-hypoxia-activated-prodrugs-of-sn-38
#7
Chen Jin, Qiumeng Zhang, Wei Lu
We designed new hypoxia-activated prodrugs by conjugating (1-methyl-2-nitro-1H-imidazol-5-yl)methanol with 7-ethyl-10-hydroxy camptothecin (SN-38). Initially, we improved the method of multi-gram scale synthesis of (1-methyl-2-nitro-1H-imidazol-5-yl)methanol, which increased the yield to 42% compared to 8% by the original synthesis method. The improved method was used to synthesize evofosfamide (TH-302) and hypoxia-activated prodrugs of SN-38. Two different linkages between (1-methyl-2-nitro-1H-imidazol-5-yl)methanol and SN-38 were evaluated that afforded different hypoxia-selectivity and toxicity...
March 22, 2017: European Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/28350894/assessing-the-amount-of-spontaneous-real-world-spoken-language-in-aphasia-validation-of-two-methods
#8
Michelle M Haddad, Edward Taub, Gitendra Uswatte, Margaret L Johnson, Victor W Mark, Ameen Barghi, Ezekiel Byrom, Xiaohua Zhou, Christina M Rodriguez
Purpose: The purpose of this article is to present the results of a study evaluating the psychometric properties of 2 new measures that exclusively assess the amount of real-world spoken language in patients with aphasia. Method: Forty individuals with aphasia were evaluated on several measures of spoken language in real-world settings. The Verbal Activity Log (VAL; Johnson et al., 2014) has participants, aided by caregivers, indicate current amount and quality of real-world spoken language compared with before stroke...
March 28, 2017: American Journal of Speech-language Pathology
https://www.readbyqxmd.com/read/28350843/high-hiv-prevalence-and-incidence-among-women-in-southern-mozambique-evidence-from-the-mdp-microbicide-feasibility-study
#9
Sibone Mocumbi, Mitzy Gafos, Khatia Munguambe, Ruth Goodall, Sheena McCormack
BACKGROUND: The study aimed to assess the feasibility of conducting large scale HIV prevention clinical trials in Mozambique by measuring HIV prevalence and incidence among women of reproductive age. This paper describes the baseline socio-demographic characteristics of the Mozambique Microbicides Development Programme (MDP) feasibility cohort, baseline prevalence of HIV and other STIs, and HIV incidence. METHODS: The Mozambique MDP feasibility study was conducted from September 2007 to August 2009 in urban Mavalane and rural Manhiça, in Southern Mozambique...
2017: PloS One
https://www.readbyqxmd.com/read/28350803/pharmacogenomic-identification-of-small-molecules-for-lineage-specific-manipulation-of-subventricular-zone-germinal-activity
#10
Kasum Azim, Diane Angonin, Guillaume Marcy, Francesca Pieropan, Andrea Rivera, Vanessa Donega, Claudio Cantù, Gareth Williams, Benedikt Berninger, Arthur M Butt, Olivier Raineteau
Strategies for promoting neural regeneration are hindered by the difficulty of manipulating desired neural fates in the brain without complex genetic methods. The subventricular zone (SVZ) is the largest germinal zone of the forebrain and is responsible for the lifelong generation of interneuron subtypes and oligodendrocytes. Here, we have performed a bioinformatics analysis of the transcriptome of dorsal and lateral SVZ in early postnatal mice, including neural stem cells (NSCs) and their immediate progenies, which generate distinct neural lineages...
March 2017: PLoS Biology
https://www.readbyqxmd.com/read/28350715/continuous-cardiac-autonomic-and-haemodynamic-responses-to-isometric-exercise
#11
Katrina A Taylor, Jonathan D Wiles, Damian D Coleman, Rajan Sharma, Jamie M O'Driscoll
PURPOSE: Elevated arterial blood pressure (BP) is associated with autonomic dysfunction and impaired haemodynamic control mechanisms. Isometric exercise (IE) training has been demonstrated effective at reducing BP; however, the continuous cardiovascular responses during IE are underinvestigated. We hypothesized that reflex autonomic cardiovascular control is an important mediator in reducing BP. To test our hypothesis, we investigated continuous cardiac autonomic modulation and baroreceptor reflex sensitivity (BRS) in response to IE...
March 27, 2017: Medicine and Science in Sports and Exercise
https://www.readbyqxmd.com/read/28350695/icrp-67-biokinetic-models-for-am-241-applied-to-nonhuman-primates
#12
Nada A Alomairy, Richard R Brey, Raymond A Guilmette
Between 1960 and 1985, Patricia Durbin and colleagues performed studies on the distribution of intravenously and intramuscularly injected Am citrate with dosages ranging from 16 to 32 kBq kg in 30 male and female non-human primates (NHP). Dr. Durbin died unexpectedly in March of 2009, leaving much of the extensive serial blood, bioassay, and autopsy data from these NHP studies unanalyzed. As part of the experimental design, serial blood samples were taken, and urine and feces samples were collected separately for the duration of the study...
May 2017: Health Physics
https://www.readbyqxmd.com/read/28350663/the-combination-of-tissue-dissection-and-external-volume-expansion-generates-large-volumes-of-adipose-tissue
#13
Yunfan He, Ziqing Dong, Gan Xie, Tao Zhou, Feng Lu
BACKGROUND: Noninvasive external volume expansion device has been applied to stimulate nonsurgical breast enlargement in clinical settings. Although previous results demonstrate the capacity of external volume expansion to increase the number of adipocytes, this strategy alone is insufficient to reconstruct soft-tissue defects or increase breast mass. The authors combined a minimally invasive tissue dissection method with external volume expansion to generate large volumes of adipose tissue...
April 2017: Plastic and Reconstructive Surgery
https://www.readbyqxmd.com/read/28350537/comparison-of-structured-and-unstructured-physical-activity-training-on-predicted-vo2max-and-heart-rate-variability-in-adolescents-a-randomized-control-trial
#14
Vivek Kumar Sharma, Senthil Kumar Subramanian, Krishnakumar Radhakrishnan, Rajathi Rajendran, Balasubramanian Sulur Ravindran, Vinayathan Arunachalam
BACKGROUND: Physical inactivity contributes to many health issues. The WHO-recommended physical activity for adolescents encompasses aerobic, resistance, and bone strengthening exercises aimed at achieving health-related physical fitness. Heart rate variability (HRV) and maximal aerobic capacity (VO2max) are considered as noninvasive measures of cardiovascular health. The objective of this study is to compare the effect of structured and unstructured physical training on maximal aerobic capacity and HRV among adolescents...
March 28, 2017: Journal of Basic and Clinical Physiology and Pharmacology
https://www.readbyqxmd.com/read/28350521/clinical-activity-of-the-%C3%AE-secretase-inhibitor-pf-03084014-in-adults-with-desmoid-tumors-aggressive-fibromatosis
#15
Shivaani Kummar, Geraldine O'Sullivan Coyne, Khanh T Do, Baris Turkbey, Paul S Meltzer, Eric Polley, Peter L Choyke, Robert Meehan, Rasa Vilimas, Yvonne Horneffer, Lamin Juwara, Ann Lih, Amul Choudhary, Sandra A Mitchell, Lee J Helman, James H Doroshow, Alice P Chen
Purpose Desmoid tumors (aggressive fibromatosis) arise from connective tissue cells or fibroblasts. In general, they are slow growing and do not metastasize; however, locally aggressive desmoid tumors can cause severe morbidity and loss of function. Disease recurrence after surgery and/or radiation and diagnosis of multifocal desmoid tumors highlight the need to develop effective systemic treatments for this disease. In this study, we evaluate objective response rate after therapy with the γ-secretase inhibitor PF-03084014 in patients with recurrent, refractory, progressive desmoid tumors...
March 28, 2017: Journal of Clinical Oncology: Official Journal of the American Society of Clinical Oncology
https://www.readbyqxmd.com/read/28350461/asymmetric-cascade-assembly-of-1-2-diaza-1-3-dienes-and-%C3%AE-%C3%AE-unsaturated-aldehydes-via-dienamine-activation
#16
Guang-Yao Ran, Ming Gong, Jing-Fei Yue, Xing-Xing Yang, Su-Lan Zhou, Wei Du, Ying-Chun Chen
A cascade vinylogous 1,6-Michael addition/1,4-proton shift/aza-Michael addition/hemiaminal formation sequence of 1,2-diaza-1,3-dienes and β-substituted 2-butenals has been developed under the influence of dienamine activation of a chiral secondary amine. This method exhibits high regio- and chemoselectivity and provides an efficient and straightforward approach to bicyclic l,8-diazabicyclo[3.3.0]octane skeletons with a tetrasubstituted stereogenic center with fair to excellent enantioselectivity.
March 28, 2017: Organic Letters
https://www.readbyqxmd.com/read/28350458/immobilization-to-positively-charged-cellulose-nanocrystals-enhances-the-antibacterial-activity-and-stability-of-hen-egg-white-and-t4-lysozyme
#17
Adel Abouhmad, Tarek Dishisha, Magdy A Amin, Rajni Hatti-Kaul
Antibacterial bionanostructures were produced from cellulose nanocrystals (CNC) with immobilized lysozyme from hen egg white (HEW) and T4 bacteriophage, respectively. The nanocrystals were prepared from microcrystalline cellulose by ammonium persulfate oxidation with a yield of 68% and having an average size of 250 nm and low polydispersity index. HEW lysozyme (HEWL) and T4 lysozyme (T4L) were immobilized to CNC by different mechanisms including adsorption, and covalent coupling to carbodiimide-activated carboxylate groups, and to glutaraldehyde-activated aminated CNC (Am-CNC), respectively...
March 28, 2017: Biomacromolecules
https://www.readbyqxmd.com/read/28350437/bacteria-activated-theranostic-nanoprobes-against-methicillin-resistant-staphylococcus-aureus-infection
#18
Zhiwei Zhao, Rong Yan, Xuan Yi, Jingling Li, Jiaming Rao, Zhengqing Guo, Yanmei Yang, Weifeng Li, Yong-Qiang Li, Chunying Chen
Despite numerous advanced imaging and sterilization techniques available nowadays, the sensitive in vivo diagnosis and complete elimination of drug-resistant bacterial infections remain to be big challenge. Here we report a strategy to design activatable theranostic nanoprobes against methicillin-resistant Staphylococcus aureus (MRSA) infections. This probe is based on silica nanoparticles coated with vancomycin-modified polyelectrolyte-cypate complexes (SiO2-Cy-Van), which is activated by an interesting phenomenon of bacteria-responsive dissociation of the polyelectrolyte from silica nanoparticles...
March 28, 2017: ACS Nano
https://www.readbyqxmd.com/read/28346994/gc-ms-analysis-and-potential-cytotoxic-activity-of-calyptranthes-grandifolia-o-berg-calyptranthes-tricona-d-legrand-and-myrciaria-plinioides-d-legrand-essential-oil-in-raw264-7-and-cho-k1-cells
#19
D Faleiro, S M Immich, F Majolo, L Mayer, E M Ethur, M I Goettert
The search for new bioactive substances derived from natural products is daily growing. Among biologically active products used in therapeutic approaches, essential oils are described with wide range of therapeutic and pharmacological potential. Plants from Myrtaceae family have the presence of essential oils in its composition. Calyptranthes grandifolia, Calyptranthes tricona and Myrciaria plinioides species belong to this family and are used by the local population. However, there are no reports in the literature describing relevant characteristics about the potential and possible activities of these species...
March 22, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28346902/in-situ-synthesis-of-cobalt-ferrites-embedded-hollow-n-doped-carbon-as-an-outstanding-catalyst-for-elimination-of-organic-pollutants
#20
Tao Zeng, Mingdong Yu, Haiyan Zhang, Zhiqiao He, Xiaole Zhang, Jianmeng Chen, Shuang Song
Using polydopamine-metal ions complex as precursor, hollow mesoporous N-doped carbon microspheres encapsulating spinel ferrites nanocrystals (HM-NC/CoFe2O4) were facilely prepared with the aim of creating a novel heterogeneous catalyst for sulfate radical-based oxidation of organic contaminants. The surface morphology, structure and composition of HM-NC/CoFe2O4 catalyst were thoroughly investigated. The applicability of the catalyst was systematically assessed through numerous controlled trials, several operating parameters, as well as different model pollutants by means of peroxymonosulfate (PMS) activation...
March 24, 2017: Science of the Total Environment
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