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https://www.readbyqxmd.com/read/29351671/a-novel-non-invasive-method-for-evaluating-electroencephalograms-on-laying-hens
#1
Krista N Eberle, Michael P Martin, Sanjay Shah, Ramon D Malheiros, Kimberly A Livingston, Kenneth E Anderson
The use of electroencephalograms (EEG) to study the avian brain relative to behavior was conducted as early as the 1960's. EEG readings, combined with visual cues, provide the ability to elucidate and correlate behaviors to neurological and physiological changes in a chicken. The use of EEG recordings in animal models require access to the brain to implant electrodes. Having the ability to observe EEG activity on sensible birds without surgical implantation could broaden the research in this area and give further insight related to the hen's state of awareness...
January 17, 2018: Poultry Science
https://www.readbyqxmd.com/read/29351660/behavior-change-is-not-one-size-fits-all-psychosocial-phenotypes-of-childhood-obesity-prevention-intervention-participants
#2
Marissa Burgermaster, Isobel Contento, Pamela Koch, Lena Mamykina
Variability in individuals' responses to interventions may contribute to small average treatment effects of childhood obesity prevention interventions. But, neither the causes of this individual variability nor the mechanism by which it influences behavior are clear. We used qualitative methods to characterize variability in students' responses to participating in a childhood obesity prevention intervention and psychosocial characteristics related to the behavior change process. We interviewed 18 students participating in a school-based curriculum and policy behavior change intervention...
January 17, 2018: Translational Behavioral Medicine
https://www.readbyqxmd.com/read/29351479/using-2h-water-to-quantify-the-contribution-of-de-novo-palmitate-synthesis-in-plasma-enabling-back-to-back-studies
#3
Stephen F Previs, Kithsiri Herath, Andrea R Nawrocki, Carlos G Rodriguez, Deborah Slipetz, Sheo B Singh, Ling Kang, Gowri Bhat, Thomas P Roddy, Stacey Conarello, Jenna Terebetski, Mark D Erion, David E Kelley
An increased contribution of de novo lipogenesis (DNL) may play a role in cases of dyslipidemia and adipose accretion, this suggests that inhibition of fatty acid synthesis may affect clinical phenotypes. Since it is not clear whether modulation of one step in the lipogenic pathway is more important than another, the use of tracer methods can provide a deeper level of insight regarding the control of metabolic activity. Although [2H]water is generally considered a reliable tracer for quantifying DNL in vivo (it yields a homogenous and quantifiable precursor labeling), the relatively long half-life of body water is thought to limit the ability of performing repeat studies in the same subjects; this can create a bottleneck in the development and evaluation of novel therapeutics for inhibiting DNL...
January 2, 2018: American Journal of Physiology. Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29351368/benefit-finding-and-diurnal-cortisol-after-prostate-cancer-the-mediating-role-of-positive-affect
#4
Ashley W Wang, Michael A Hoyt
OBJECTIVE: Benefit finding (BF) has exhibited a salutary effect on psychological adjustment to cancer. However, few studies have examined its relationship with physiology or have examined BF in men with cancer. This study investigated whether BF is associated with Hypothalamic-Pituitary-Adrenal (HPA) axis activity (i.e., diurnal salivary cortisol) in men treated for prostate cancer. Positive affect (PA) is proposed as a potential pathway linking BF to diurnal salivary cortisol. METHODS: A sample of 66 men treated for localized prostate cancer within the prior two years completed questionnaires and collected salivary cortisol three times per day over three consecutive days...
January 19, 2018: Psycho-oncology
https://www.readbyqxmd.com/read/29351333/simultaneous-quantification-of-four-antiretroviral-drugs-in-breast-milk-samples-from-hiv-positive-women-by-an-ultra-high-performance-liquid-chromatography-tandem-mass-spectrometry-uplc-ms-ms-method
#5
Alicia Ramírez-Ramírez, Elías Sánchez-Serrano, Giselle Loaiza-Flores, Noemí Plazola-Camacho, Rosa Georgina Rodríguez-Delgado, Ricardo Figueroa-Damián, Mauricio Domínguez-Castro, Margarita López-Martínez, Zayra Flores-García, Jessica Hernández-Pineda
The primary strategy to avoid mother-to-child transmission of human immunodeficiency virus (HIV) through breastfeeding is administration of highly active antiretroviral therapy (HAART) to HIV-positive pregnant women. Because significant changes in the pharmacokinetics of antiretroviral (ARV) drugs occur during pregnancy, quantifying HAART and the viral load in breast milk in this population is essential. Here, we developed an analytical assay for the simultaneous quantification of four ARV drugs in breast milk using ultra-performance liquid chromatography coupled to tandem mass spectrometry...
2018: PloS One
https://www.readbyqxmd.com/read/29351315/large-scale-mapping-of-bioactive-peptides-in-structural-and-sequence-space
#6
Agustina E Nardo, M Cristina Añón, Gustavo Parisi
Health-enhancing potential bioactive peptide (BP) has driven an interest in food proteins as well as in the development of predictive methods. Research in this area has been especially active to use them as components in functional foods. Apparently, BPs do not have a given biological function in the containing proteins and they do not evolve under independent evolutionary constraints. In this work we performed a large-scale mapping of BPs in sequence and structural space. Using well curated BP deposited in BIOPEP database, we searched for exact matches in non-redundant sequences databases...
2018: PloS One
https://www.readbyqxmd.com/read/29351286/socio-economic-determinants-of-physical-activity-across-the-life-course-a-determinants-of-diet-and-physical-activity-dedipac-umbrella-literature-review
#7
Grainne O'Donoghue, Aileen Kennedy, Anna Puggina, Katina Aleksovska, Christoph Buck, Con Burns, Greet Cardon, Angela Carlin, Donatella Ciarapica, Marco Colotto, Giancarlo Condello, Tara Coppinger, Cristina Cortis, Sara D'Haese, Marieke De Craemer, Andrea Di Blasio, Sylvia Hansen, Licia Iacoviello, Johann Issartel, Pascal Izzicupo, Lina Jaeschke, Martina Kanning, Fiona Ling, Agnes Luzak, Giorgio Napolitano, Julie-Anne Nazare, Camille Perchoux, Caterina Pesce, Tobias Pischon, Angela Polito, Alessandra Sannella, Holger Schulz, Chantal Simon, Rhoda Sohun, Astrid Steinbrecher, Wolfgang Schlicht, Ciaran MacDonncha, Laura Capranica, Stefania Boccia
BACKGROUND: To date, the scientific literature on socioeconomic correlates and determinants of physical activity behaviours has been dispersed throughout a number of systematic reviews, often focusing on one factor (e.g. education or parental income) in one specific age group (e.g. pre-school children or adults). The aim of this umbrella review is to provide a comprehensive and systematic overview of the scientific literature from previously conducted research by summarising and synthesising the importance and strength of the evidence related to socioeconomic correlates and determinants of PA behaviours across the life course...
2018: PloS One
https://www.readbyqxmd.com/read/29351266/from-extraction-of-local-structures-of-protein-energy-landscapes-to-improved-decoy-selection-in-template-free-protein-structure-prediction
#8
Nasrin Akhter, Amarda Shehu
Due to the essential role that the three-dimensional conformation of a protein plays in regulating interactions with molecular partners, wet and dry laboratories seek biologically-active conformations of a protein to decode its function. Computational approaches are gaining prominence due to the labor and cost demands of wet laboratory investigations. Template-free methods can now compute thousands of conformations known as decoys, but selecting native conformations from the generated decoys remains challenging...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29351256/immobilization-of-staphylococcus-aureus-sortase-a-on-chitosan-particles-and-its-applications-in-peptide-to-peptide-ligation-and-peptide-cyclization
#9
Min Yang, Haofei Hong, Shaozhong Liu, Xinrui Zhao, Zhimeng Wu
Chitosan macro-particles prepared by the neutralization method were applied to Sortase A (SrtA) immobilization using glutaraldehyde as a crosslinking agent. The particles were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Response surface methodology (RSM) was employed to optimize the immobilization process. An average specific activity of 3142 U (mg protein)-1 was obtained under optimized immobilization conditions (chitosan concentration 3%, SrtA concentration 0...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29351216/in-silico-and-in-vitro-study-of-the-bromelain-phytochemical-complex-inhibition-of-phospholipase-a2-pla2
#10
Fatahiya Mohamed Tap, Fadzilah Adibah Abd Majid, Hassan Fahmi Ismail, Tet Soon Wong, Kamyar Shameli, Mikio Miyake, Nurul Bahiyah Ahmad Khairudin
Phospholipase A2 (Pla2) is an enzyme that induces inflammation, making Pla2 activity an effective approach to reduce inflammation. Therefore, investigating natural compounds for this Pla2 inhibitory activity has important therapeutic potential. The objective of this study was to investigate the potential in bromelain-phytochemical complex inhibitors via a combination of in silico and in vitro methods. Bromelain-amenthoflavone displays antagonistic effects on Pla2. Bromelian-asiaticoside and bromelain-diosgenin displayed synergistic effects at high concentrations of the combined compounds, with inhibition percentages of more than 70% and 90%, respectively, and antagonistic effects at low concentrations...
January 19, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29351211/wide-field-fluorescence-microscopy-of-real-time-bioconjugation-sensing
#11
Marcin Szalkowski, Karolina Sulowska, Justyna Grzelak, Joanna Niedziółka-Jönsson, Ewa Roźniecka, Dorota Kowalska, Sebastian Maćkowski
We apply wide-field fluorescence microscopy to measure real-time attachment of photosynthetic proteins to plasmonically active silver nanowires. The observation of this effect is enabled, on the one hand, by sensitive detection of fluorescence and, on the other hand, by plasmonic enhancement of protein fluorescence. We examined two sample configurations with substrates being a bare glass coverslip and a coverslip functionalized with a monolayer of streptavidin. The different preparation of the substrate changes the observed behavior as far as attachment of the protein is concerned as well as its subsequent photobleaching...
January 19, 2018: Sensors
https://www.readbyqxmd.com/read/29351162/potentiation-effects-of-the-french-contrast-method-on-the-vertical-jumping-ability
#12
Joseba Andoni Hernández-Preciado, Eneko Baz, Carlos Balsalobre-Fernández, David Marchante, Jordan Santos-Concejero
This study examined the acute effects of the potentiation protocol known as French Contrast Method on the vertical jumping ability measured by a countermovement jump (CMJ). 31 athletes participated in the study (intervention group n=17 and control group n=14). The CMJ height was measured using the IOS application MyJump App 2.0 pre- and post- the French Contrast protocol, which consisted of 3 sets of isometric partial squats, drop jumps, dynamic half-squats and hurdle jumps. The CMJ height improved from its baseline values by 5...
January 17, 2018: Journal of Strength and Conditioning Research
https://www.readbyqxmd.com/read/29351124/feasibility-assessment-of-yttrium-90-liver-radioembolization-imaging-using-amplitude-based-gated-pet-ct
#13
Dustin R Osborne, Shelley N Acuff, Melissa L Neveu, Mumtaz Syed, Austin D Kaman, Yitong Fu
PURPOSE: The usage of PET/computed tomography (CT) to monitor hepatocellular carcinoma patients following yttrium-90 (Y) radioembolization has increased. Respiratory motion causes liver movement, which can be corrected using gating techniques at the expense of added noise. This work examines the use of amplitude-based gating on Y-PET/CT and its potential impact on diagnostic integrity. PATIENTS AND METHODS: Patients were imaged using PET/CT following Y radioembolization...
January 18, 2018: Nuclear Medicine Communications
https://www.readbyqxmd.com/read/29350787/fathers-experiences-with-their-preterm-babies-admitted-to-neonatal-intensive-care-unit-a-multi-method-study
#14
Alberto Stefana, Ezio Maria Padovani, Paolo Biban, Manuela Lavelli
AIM: The aim of this study was to investigate fathers' emotional experiences of their infant's preterm birth and subsequent stay in neonatal intensive care unit. BACKGROUND: When a baby is born preterm, there is also the premature interruption of the process of preparation for fatherhood. As a result, the impact on fathers of the preterm birth can bring negative consequences for the development of father-infant relationship. DESIGN: A multi-method approach was used which included ethnographic observation, semi-structured interviews with fathers, a self-report questionnaire and clinical information between September 2015-March 2017...
January 19, 2018: Journal of Advanced Nursing
https://www.readbyqxmd.com/read/29350740/full-dimensional-analytical-potential-energy-surface-describing-the-gas-phase-cl-c2h6-reaction-and-kinetics-study-of-rate-constants-and-kinetic-isotope-effects
#15
Cipriano Rangel, Joaquin Espinosa-Garcia
Within the Born-Oppenheimer approximation a full-dimensional analytical potential energy surface, PES-2017, was developed for the gas-phase hydrogen abstraction reaction between the chlorine atom and ethane, which is a nine body system. This surface presents a valence-bond/molecular mechanics functional form dependent on 60 parameters and is fitted to high-level ab initio calculations. This reaction presents little exothermicity, -2.30 kcal mol-1, with a low height barrier, 2.44 kcal mol-1, and intermediate complexes in the entrance and exit channels...
January 19, 2018: Physical Chemistry Chemical Physics: PCCP
https://www.readbyqxmd.com/read/29350685/re-orchestration-of-blood-flow-by-micro-circulations
#16
P A R Meyer
Haemoglobin Video Imaging (HVI) demonstrates conjunctival and episcleral blood flow in man with the resolution of a single erythrocyte. A new method for establishing vessel hierarchy in micro-circulations is described, which recognises either delivery or drainage vessels and references vessel order to the capillary. These tools have been used to characterise blood flow.Anterior ciliary arteries show pulsatile variation in diameter. The episcleral arterial circle that they supply has functional apices with pulsatile flow reversal...
January 19, 2018: Eye
https://www.readbyqxmd.com/read/29350655/brass-score-a-pro-active-method-of-management-for-complex-discharge
#17
Valentina Cammilletti, Fortunata Forino, Marina Palombi, Daniele Donati, Daniela Tartaglini, Marco Di Muzio
AIMS: A highly functional continuity of patient care, which is linked to the reduction of the risk of long-term hospitalization, above all for 'at-risk' patients. Research into an objective, reliable instrument for redirecting individual results to organizational aims to extend the entire country, is a fundamental step to move from a reactive assistance approach to a pro-active one. METHODS: An observational and descriptive retrospective study was carried out July - November 2014 in two Italian state hospitals, completing the BRASS Index within 48/72 hours of admission...
January 16, 2018: Acta Bio-medica: Atenei Parmensis
https://www.readbyqxmd.com/read/29350621/electrodeposited-binder-free-nico2o4-carbon-nanofiber-as-high-performance-anode-for-lithium-ion-batteries
#18
Jie Zhang, Ruixia Chu, Yanli Chen, Heng Jiang, Ying Zhang, Nay Ming Huang, Hang Guo
Binder-free nickle cobaltite on carbon nanofiber (NiCo2O4@CNF) anode for lithium ion batteries was prepared via a two-step procedure of electrospinning and electrodeposition. The CNF was obtained by annealing the electrospun poly-acrylonitrile (PAN) in the nitrogen (N2). The NiCo2O4 nanostructures were then grown on the CNF by electrodeposition, followed by annealing in the air. Experimental results showed vertically aligned NiCo2O4 nanosheets were uniformly grown on the surface of CNF, forming an interconnected network...
January 19, 2018: Nanotechnology
https://www.readbyqxmd.com/read/29350596/enhancement-of-antitumor-activity-by-using-5-ala-mediated-sonodynamic-therapy-to-induce-apoptosis-in-malignant-gliomas-significance-of-high-intensity-focused-ultrasound-on-5-ala-sdt-in-a-mouse-glioma-model
#19
Satoshi Suehiro, Takanori Ohnishi, Daisuke Yamashita, Shohei Kohno, Akihiro Inoue, Masahiro Nishikawa, Shiro Ohue, Junya Tanaka, Takeharu Kunieda
OBJECTIVE High invasiveness of malignant gliomas frequently causes early local recurrence of the tumor, resulting in extremely poor outcome. To control such recurrence, novel therapies targeted toward infiltrating glioma cells around the tumor border are required. Here, the authors investigated the antitumor activity of sonodynamic therapy (SDT) combined with a sonosensitizer, 5-aminolevulinic acid (5-ALA), on malignant gliomas to explore the possibility for clinical use of 5-ALA-mediated SDT (5-ALA-SDT). METHODS In vitro cytotoxicity of 5-ALA-SDT was evaluated in U87 and U251 glioma cells and in U251Oct-3/4 glioma stemlike cells...
January 19, 2018: Journal of Neurosurgery
https://www.readbyqxmd.com/read/29350595/motor-network-recovery-in-patients-with-chronic-spinal-cord-compression-a-longitudinal-study-following-decompression-surgery
#20
Kayla Ryan, Sandy Goncalves, Robert Bartha, Neil Duggal
OBJECTIVE The authors used functional MRI to assess cortical reorganization of the motor network after chronic spinal cord compression and to characterize the plasticity that occurs following surgical intervention. METHODS A 3-T MRI scanner was used to acquire functional images of the brain in 22 patients with reversible cervical spinal cord compression and 10 control subjects. Controls performed a finger-tapping task on 3 different occasions (baseline, 6-week follow-up, and 6-month follow-up), whereas patients performed the identical task before surgery and again 6 weeks and 6 months after spinal decompression surgery...
January 19, 2018: Journal of Neurosurgery. Spine
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