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https://www.readbyqxmd.com/read/29169158/potential-targets-and-clinical-value-of-mir-224-5p-in-cancers-of-the-digestive-tract
#1
Lu Zhang, Lan-Shan Huang, Gang Chen, Zhen-Bo Feng
BACKGROUND/AIMS: MicroRNAs participate in various biological processes in malignant tumors. However, the mechanisms of miR-224-5p in digestive system cancers are not fully understood. A comprehensive investigation of the clinical value and potential targets of miR-224-5p in cancers of the digestive tract is necessary. METHODS: Expression profiling data and related-prognostic data of miR-224-5p were acquired from Gene Expression Omnibus, The Cancer Genome Atlas, ArrayExpress, and published literature...
November 23, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/29169140/facile-green-synthesis-of-zinc-oxide-nanoparticles-using-ulva-lactuca-seaweed-extract-and-evaluation-of-their-photocatalytic-antibiofilm-and-insecticidal-activity
#2
Ramachandran Ishwarya, Baskaralingam Vaseeharan, Subramanian Kalyani, Balan Banumathi, Marimuthu Govindarajan, Naiyf S Alharbi, Shine Kadaikunnan, Mohammed N Al-Anbr, Jamal M Khaled, Giovanni Benelli
The bioactivity of semiconductor nanocomplexes has been poorly studied in the field of pesticide science. In this research, the synthesis of zinc nanoparticles was accomplished through new effortless green chemistry process, using the Ulva lactuca seaweed extract as a reducing and capping agent. The production of U. lactuca-fabricated ZnO nanoparticles (Ul-ZnO Nps) was characterized by powder X-ray diffraction (XRD), UV-visible, Fourier transform infrared (FTIR) spectroscopy, selected area electron diffraction (SAED) analysis and transmission electron microscopy (TEM)...
November 7, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29169114/evaluation-of-antiparkinson-activity-of-ptupb-by-measuring-dopamine-and-its-metabolites-in-drosophila-melanogaster-lc-ms-ms-method-development
#3
Navya Lakkappa, Praveen T Krishnamurthy, Karthik Yamjala, Sung Hee Hwang, Bruce D Hammock, B Babu
Soluble epoxide hydrolase (sEH) inhibition is reported to elevate endogenous epoxyeicosatrienoic acids (EET's), which are known to play an important role in neuroprotection by inhibiting oxidative stress and neuroinflammation. In the present study, PTUPB, a dual inhibitor of sEH and COX-2, has been tested for its antiparkinson activity against rotenone (ROT) induced neurodegeneration in Drosophila model of Parkinson's disease (PD). To determine the efficacy and brain bioavailability of PTUPB a simple, rapid and sensitive LC-MS/MS method was developed and validated for the estimation of PTUPB (Method-I), dopamine (DA) and its metabolites (Method-II) in fly head...
November 16, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169112/analysis-of-unbound-plasma-concentration-of-oxcarbazepine-and-the-10-hydroxycarbazepine-enantiomers-by-liquid-chromatography-with-tandem-mass-spectrometry-in-healthy-volunteers
#4
Natalícia de Jesus Antunes, Lauro Wichert-Ana, Eduardo Barbosa Coelho, Oscar Della Pasqua, Veriano Alexandre Junior, Osvaldo Massaiti Takayanagui, Maria Paula Marques, Vera Lucia Lanchote
This study describes the development and validation of a method for the analysis of unbound plasma concentrations of oxcarbazepine (OXC) and of the enantiomers of its active metabolite 10-hydroxycarbazepine (MHD) [S-(+)- and R-(-)-MHD] using liquid chromatography with tandem mass spectrometry (LC-MS/MS). Additionally, the free fraction of the drug is described in healthy volunteers (n=12) after the oral administration of 300mg OXC/12h for 5days. Plasma aliquots of 200μL were submitted to ultrafiltration procedure and 50μL of the ultrafiltrate were extracted with a mixture of tert-butyl methyl ether:dichloromethane (2:1, v/v)...
November 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169111/identification-of-phenolic-components-via-lc-ms-analysis-and-biological-activities-of-two-centaurea-species-c-drabifolia-subsp-drabifolia-and-c-lycopifolia
#5
Gokhan Zengin, Dimitrina Zheleva-Dimitrova, Reneta Gevrenova, Paraskev Nedialkov, Andrei Mocan, Ana Ćirić, Jasmina Glamočlija, Marina Soković, Abdurrahman Aktumsek, M Fawzi Mahomoodally
The Centaurea genus has great potential in traditional systems and has attracted much interest in the design of novel drug formulations. The present study was focused on the chemical fingerprints and biological properties of Centaurea drabifolia subsp. drabifolia and Centaurea lycopifolia extracts. Spectrophotometric and LC-MS techniques were used to establish the chemical profiles of the studied extracts. Enzyme inhibitory potential was assessed against key enzymes linked to global health problems, namely neurodegenerative diseases (acetylcholinesterase), pigmentation (tyrosinase), and diabetes (α-amylase and α-glucosidase)...
November 20, 2017: Journal of Pharmaceutical and Biomedical Analysis
https://www.readbyqxmd.com/read/29169061/measurement-of-cross-sections-for-14mev-neutron-interaction-with-175-lu
#6
Zhengwei Zhang, Qian Zhang, Shihong Chen, Bingjun Chen, Qiang Wang, Caifeng Lai, Kaihong Fang
The cross-sections for 14MeV neutron interaction with (175)Lu were precisely measured by the neutron activation and off-line gamma ray technique. The neutron fluence was monitored by the accompanying α-particle of the T(d,n)α reaction, and the neutron energies were determined by using the cross-section ratio method of (90)Zr(n,2n)(89)Zr to (93)Nb(n,2n)(92m)Nb reactions. As a result, the cross-sections of (175)Lu(n,2n)(174m)Lu, (175)Lu(n,2n)(174g)Lu, (175)Lu(n,p)(175m+g)Yb and (175)Lu(n,α)(172)Tm reactions have been deduced at En = 14...
November 14, 2017: Applied Radiation and Isotopes
https://www.readbyqxmd.com/read/29168972/experience-of-violence-amongst-female-medical-and-nursing-students-and-their-perception-regarding-violence-against-women-in-delhi-india
#7
Nitika Gautam, Tanu Anand, Jugal Kishore, Shekhar Grover
Background Health care providers are often the first point of contact for the victims of violence against women (VAW). Therefore, it is important to understand their perception about VAW. Objective To assess the proportion of female medical students who experienced violence, and elicit their perception regarding the same. Methods It was a cross-sectional study undertaken among 50 medical and 50 nursing students of a medical college in Central Delhi. A self-administered, questionnaire was used for data collection...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168969/comparing-health-promotion-behaviors-of-male-and-female-high-school-students-in-southeast-of-iran
#8
Nasibeh Salari, Jamileh Farokhzadian, Faroukh Abazari
Background Adolescence is one of the most challenging periods of human life. Many healthy or risky behaviors may be formed during this period and continue to the end of life. The aim of this study was to examine and compare the health promotion behaviors of male and female students in high schools. Methods In this descriptive-comparative study, 609 high school students were selected using multi-stage random sampling method. Data were collected using demographic and health-promoting lifestyle profile (HPLPII) questionnaires...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168957/the-effects-of-introducing-tabata-interval-training-and-stability-exercises-to-school-children-as-a-school-based-intervention-program
#9
Annika Ekström, Anna Hafsteinsson Östenberg, Glenn Björklund, Marie Alricsson
Background Physical activities during leisure time as well as school hours have changed over the past few years, with adolescents being less physically active and adopting a sedentary lifestyle. Objective The overall objective of this mixed-methods study was to evaluate the feasibility of introducing a 4-min Tabata interval training into a lower secondary school context. A further aim was to evaluate the possible effects on: coordination, balance, and strength. Methods The study was conducted as an intervention study with a mixed-method approach...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168955/adherence-to-a-mediterranean-dietary-pattern-and-overweight-and-obesity-among-female-adolescents-in-iran
#10
Fatemeh Sedaghat, Farah Naja, Mina Darand, Bita Beyzai, Bahram Rashidkhani
Background Given the high prevalence of overweight and obesity in Iran, identification of a healthy diet is essential. Objective This study aimed to assess the association between adherence to a Mediterranean diet and overweight and obesity in female adolescents. Methods Two hundred and eighty female adolescents from high schools in Tehran were recruited. General information, physical activity and food frequency questionnaires were completed. Adherence to the Mediterranean diet was evaluated using the Mediterranean Style Dietary Pattern Score (MSDPS)...
November 23, 2017: International Journal of Adolescent Medicine and Health
https://www.readbyqxmd.com/read/29168908/the-rickiols-20-22-and-24-membered-macrolides-from-the-ascomycete-hypoxylon-rickii
#11
Frank Surup, Eric Kuhnert, Andreas Böhm, Vincent Wiebach, Danny Solga, Hauke Engler, Tim Pendzialek, Albrecht Berkessel, Marc Stadler, Markus Kalesse
In preceding studies the neotropical ascomycete Hypoxylon rickii turned out to be a prolific source of new secondary metabolites since we had obtained terpenoids with five different scaffolds besides a series of terphenyls. From the mycelial extracts of a 70 L scale fermentation of this strain we additionally isolated nine new macrolides (1 - 9) by RP-HPLC. Their planar structures were elucidated by NMR spectroscopy complemented by HR-ESIMS. The relative configurations were assigned by J-based configuration analyses and confirmed by Kishi's universal database...
November 23, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/29168902/an-in-situ-thermally-regenerated-air-purifier-for-indoor-formaldehyde-removal
#12
Ru Xiao, Jinhan Mo, Yinping Zhang, Dewen Gao
Formaldehyde is a common indoor pollutant that is an irritant and has been classified as carcinogen to humans. Adsorption technology is safe and stable and removes formaldehyde efficiently, but its short lifespan and low adsorption capacity limit its indoor application. To overcome these limitations, we propose an in-situ thermally regenerated air purifier (TRAP) which self-regenerates as needed. This purifier has four working modes: cleaning mode, regeneration mode, exhaust mode and outdoor air in-take mode, all of which are operated by valve switching...
November 23, 2017: Indoor Air
https://www.readbyqxmd.com/read/29168799/modulation-of-cytochrome-p450-p-glycoprotein-and-pregnane-x-receptor-by-selected-antimalarial-herbs-implication-for-herb-drug-interaction
#13
Pius S Fasinu, Vamshi K Manda, Olivia R Dale, Nosa O Egiebor, Larry A Walker, Shabana I Khan
Seven medicinal plants popularly used for treating malaria in West Africa were selected to assess herb-drug interaction potential through a series of in vitro methods. Fluorescent cytochrome P450 (CYP) assays were conducted using the recombinant CYP enzymes for CYP1A2, CYP2A6, CYP2B6, CYP2C9, CYP2C19, CYP2D6 and CYP3A4 to assess the effect of the methanolic extracts on the metabolic activity of CYPs. Secondly, the inhibitory effect of the extracts was evaluated on P-glycoproteins (P-gp) using calcein-AM, a fluorescent substrate, in MDCK-II and hMDR1-MDCK-II cells...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168788/microtubule-depolymerization-by-kinase-inhibitors-unexpected-findings-of-dual-inhibitors
#14
REVIEW
Kenji Tanabe
Microtubule-targeting agents are widely used as clinical drugs in the treatment of cancer. However, some kinase inhibitors can also disrupt microtubule organization by directly binding to tubulin. These unexpected effects may result in a plethora of harmful events and/or a misinterpretation of the experimental results. Thus, further studies are needed to understand these dual inhibitors. In this review, I discuss the roles of dual inhibitors of kinase activity and microtubule function as well as describe the properties underlining their dual roles...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168787/fred-exergame-to-prevent-dependence-and-functional-deterioration-associated-with-ageing-a-pilot-three-week-randomized-controlled-clinical-trial
#15
Iranzu Mugueta-Aguinaga, Begonya Garcia-Zapirain
Introduction: Frailty syndrome and advanced age may decrease the acceptance of illness and quality of life, and worsen patients' existing health conditions, as well as leading to an increase in health care expenses. Purpose: The purpose of this study is to reduce frailty risk via the use of a FRED game which has been expressly designed and put together for the study. Materials and methods: A total of 40 frail volunteers with a score of <10 points in the short physical performance battery (SPPB) took part in a feasibility study in order to validate the FRED game...
November 23, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29168769/early-detection-of-the-initiation-of-sit-to-stand-posture-transitions-using-orthosis-mounted-sensors
#16
Abul Doulah, Xiangrong Shen, Edward Sazonov
Assistance during sit-to-stand (SiSt) transitions for frail elderly may be provided by powered orthotic devices. The control of the powered orthosis may be performed by the means of electromyography (EMG), which requires direct contact of measurement electrodes to the skin. The purpose of this study was to determine if a non-EMG-based method that uses inertial sensors placed at different positions on the orthosis, and a lightweight pattern recognition algorithm may accurately identify SiSt transitions without false positives...
November 23, 2017: Sensors
https://www.readbyqxmd.com/read/29168766/tityus-serrulatus-scorpion-venom-in-vitro-tests-and-their-correlation-with-in-vivo-lethal-dose-assay
#17
Daniela Cajado-Carvalho, Juliana Galvão, Alexandre K Kuniyoshi, Patrícia Dos Santos Carneiro, Adriana Franco Paes Leme, Bianca Alves Pauletti, Eliana Blini Marengo, Fernanda V Portaro
Scorpion stings are the main cause of human envenomation in Brazil and, for the treatment of victims, the World Health Organization (WHO) recommends the use of antivenoms. The first step to achieve effective antivenom is to use a good quality venom pool and to evaluate it, with LD50 determination as the most accepted procedure. It is, however, time-consuming and requires advanced technical training. Further, there are significant ethical concerns regarding the number of animals required for testing. Hence, we investigated the correspondence between LD50 results, in vitro assays, and a strong correlation with proteolytic activity levels was observed, showing, remarkably, that proteases are potential toxicity markers for Tityus serrulatus venom...
November 23, 2017: Toxins
https://www.readbyqxmd.com/read/29168753/recyclable-magnetic-titania-nanocomposite-from-ilmenite-with-enhanced-photocatalytic-activity
#18
Tianjie Hong, Jun Mao, Feifei Tao, Mingxuan Lan
Using ilmenite as a raw material, iron was converted into Fe₃O₄ magnetic fluid, which further was combined with titanium filtrate by a solvothermal method. Finally Fe₃O₄/TiO₂ nanocomposites with the uniform size of 100-200 nm were prepared. This approach uses rich, inexpensive ilmenite as a titanium and iron source, which effectively reduces the production cost. The crystal structure, chemical properties and morphologies of the products were characterized by SEM, TEM, XRD, FTIR, BET, UV-Vis, XPS and VSM...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168743/synthesis-and-anticandidal-activity-evaluation-of-new-benzimidazole-thiazole-derivatives
#19
Zafer Asım Kaplancıklı, Serkan Levent, Derya Osmaniye, Begüm Nurpelin Sağlık, Ulviye Acar Çevik, Betül Kaya Çavuşoğlu, Yusuf Özkay, Sinem Ilgın
Azole-based antifungal agents constitute one of the important classes of antifungal drugs. Hence, in the present work, 12 new benzimidazole-thiazole derivatives 3a-3l were synthesized to evaluate their anticandidal activity against C.albicans, C.glabrata, C.krusei, and C.parapsilopsis. The structures of the newly synthesized compounds 3a-3l were confirmed by IR, ¹H-NMR, (13)C-NMR, and ESI-MS spectroscopic methods. ADME parameters of synthesized compounds 3a-3l were predicted by an in-slico study and it was determined that all synthesized compounds may have a good pharmacokinetic profile...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29168734/impact-of-ohmic-assisted-decoction-on-bioactive-components-extracted-from-yacon-smallanthus-sonchifolius-poepp-leaves-comparison-with-conventional-decoction
#20
Forough Khajehei, Mehrdad Niakousari, Maral Seidi Damyeh, Nikolaus Merkt, Wilhelm Claupein, Simone Graeff-Hoenninger
Yacon (Smallanthus sonchifolius Poepp.) leaves are a potentially rich source of bioactive compounds, such as phenolic acids and flavonoids. In this study, the effect of the extraction method (ohmic-assisted decoction (OH-DE) and decoction (DE)), yacon cultivar (red and white), and leaf age (young and old) on the quality/quantity of extracted phytochemicals were investigated. Extraction yield, energy consumption, total phenolic content (TPC), total flavonoid content (TFC), ABTS and DPPH radical scavenging activity, and ferric reducing antioxidant power (FRAP) were determined...
November 23, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
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