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interferon regulatory factor 7

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https://www.readbyqxmd.com/read/29792850/microrna-182-inhibits-hcmv-replication-through-activation-of-type-i-ifn-response-by-targeting-foxo3
#1
Xia He, Junfang Teng, Can Cui, Dongrui Li, Lijun Wen
Human cytomegalovirus (HCMV) has led to kinds of clinical disorders and great morbidity worldwide, such as sensorineural hearing loss (SNHL), mental retardation, and developmental delays in immunocompromised individuals. Previous studies reported that HCMV has evolved a variety of mechanisms to evade the immune system, such as dysregulation of miRNAs. However, reports concerning the role of miRNA in HCMV infection are limited. Here, we reported that a host microRNA, miR-182, was significantly up-regulated by HCMV infection in U-251MG and NPCs cells...
May 21, 2018: Experimental Cell Research
https://www.readbyqxmd.com/read/29751576/thymoquinone-suppresses-irf-3-mediated-expression-of-type-i-interferons-via-suppression-of-tbk1
#2
Nur Aziz, Young-Jin Son, Jae Youl Cho
Interferon regulatory factor (IRF)-3 is known to have a critical role in viral and bacterial innate immune responses by regulating the production of type I interferon (IFN). Thymoquinone (TQ) is a compound derived from black cumin ( Nigella sativa L.) and is known to regulate immune responses by affecting transcription factors associated with inflammation, including nuclear factor-κB (NF-κB) and activator protein-1 (AP-1). However, the role of TQ in the IRF-3 signaling pathway has not been elucidated...
May 3, 2018: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29740426/multipotent-adult-progenitor-cells-suppress-t-cell-activation-in-in-vivo-models-of-homeostatic-proliferation-in-a-prostaglandin-e2-dependent-manner
#3
Fiona Carty, Jennifer M Corbett, João Paulo M C M Cunha, James L Reading, Timothy I M Tree, Anthony E Ting, Samantha R Stubblefield, Karen English
Lymphodepletion strategies are used in the setting of transplantation (including bone marrow, hematopoietic cell, and solid organ) to create space or to prevent allograft rejection and graft versus host disease. Following lymphodepletion, there is an excess of IL-7 available, and T cells that escape depletion respond to this cytokine undergoing accelerated proliferation. Moreover, this environment promotes the skew of T cells to a Th1 pro-inflammatory phenotype. Existing immunosuppressive regimens fail to control this homeostatic proliferative (HP) response, and thus the development of strategies to successfully control HP while sparing T cell reconstitution (providing a functioning immune system) represents a significant unmet need in patients requiring lymphodepletion...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29732997/hydroxysafflor-yellow-a-reprograms-tlr9-signalling-pathway-in-ischaemic-cortex-after-cerebral-ischaemia-and-reperfusion
#4
Zhe Gong, Jingrui Pan, Xiangpen Li, Hongxuan Wang, Lei He, Ying Peng
Hydroxysafflor yellow A (HSYA) was reported to suppress inflammation in ischaemic microglia. However, the mechanism through which HSYA inhibits inflammation caused by cerebral ischaemia and reperfusion injury remains unknown. Here, we have mimicked acute cerebral ischaemia and reperfusion injury by subjecting male Sprague-Dawley (SD) rats to transient middle cerebral artery occlusion for 90 minutes and have demonstrated that toll-like receptor 9 (TLR9) was upregulated from day 3 after reperfusion, accompanied by the persistent activation of the pro-inflammatory NF-κB pathway from 6 hours to day 7...
May 1, 2018: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/29721746/signal-propagation-in-sensing-and-reciprocating-cellular-systems-with-spatial-and-structural-heterogeneity
#5
Arran Hodgkinson, Gilles Uzé, Ovidiu Radulescu, Dumitru Trucu
Sensing and reciprocating cellular systems (SARs) are important for the operation of many biological systems. Production in interferon (IFN) SARs is achieved through activation of the Jak-Stat pathway, and downstream upregulation of IFN regulatory factor (IRF)-7 and IFN transcription, but the role that high- and low-affinity IFNs play in this process remains unclear. We present a comparative between a minimal spatio-temporal partial differential equation model and a novel spatio-structural-temporal (SST) model for the consideration of receptor, binding, and metabolic aspects of SAR behaviour...
May 2, 2018: Bulletin of Mathematical Biology
https://www.readbyqxmd.com/read/29720400/interferon-regulatory-factor-1-and-a-variant-of-heterogeneous-nuclear-ribonucleoprotein-l-coordinately-silence-the-gene-for-adhesion-protein-ceacam1
#6
Kenneth J Dery, Craig Silver, Lu Yang, John E Shively
The adhesion protein Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) is widely expressed in epithelial cells as a short cytoplasmic isoform (S-iso) and in leukocytes as a long cytoplasmic isoform (L-iso) and is frequently silenced in cancer by unknown mechanisms. Previously, we reported that interferon response factor 1 (IRF1) biases alternative splicing (AS) to include the variable exon 7 in CEACAM1, generating L-iso. We now show that IRF1 and a variant of heterogeneous nuclear ribonucleoprotein L (Lv1) coordinately silence the CEACAM1 gene...
May 2, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29717061/the-interaction-between-ikk%C3%AE-and-lc3-promotes-type-i-interferon-production-through-the-tlr9-containing-laposome
#7
Kachiko Hayashi, Manabu Taura, Akiko Iwasaki
Toll-like receptor 9 (TLR9) recognizes DNA in endosomes and activates distinct signaling pathways to stimulate the production of proinflammatory cytokines and type I interferons (IFNs). The assembly of signaling platforms on microtubule-associated proteins 1A/1B-light chain 3 (LC3)-decorated endosomal vesicles is required to transduce TLR9 signals that stimulate the production of IFN but not interleukin-12 p40 (IL-12p40). LC3-associated phagocytosis (LAP), a form of noncanonical autophagy, is critical for the activation of interferon regulatory factor 7 (IRF7) and for IFN synthesis...
May 1, 2018: Science Signaling
https://www.readbyqxmd.com/read/29664568/the-role-of-cytokines-in-t-cell-memory-in-health-and-disease
#8
REVIEW
Miro E Raeber, Yves Zurbuchen, Daniela Impellizzieri, Onur Boyman
Upon stimulation with their cognate antigen, naive T cells undergo proliferation and differentiation into effector cells, followed by apoptosis or survival as precursors of long-lived memory cells. These phases of a T-cell response and the ensuing maintenance of memory T cells are shaped by cytokines, most notably interleukin-2 (IL-2), IL-7, and IL-15 that share the common γ chain (γc ) cytokine receptor. Steady-state production of IL-7 and IL-15 is necessary for background proliferation and homeostatic survival of CD4+ and CD8+ memory T cells...
May 2018: Immunological Reviews
https://www.readbyqxmd.com/read/29618514/activation-of-stimulator-of-interferon-genes-sting-induces-adam17-mediated-shedding-of-the-immune-semaphorin-sema4d
#9
Kou Motani, Hidetaka Kosako
Stimulator of interferon genes (STING) is an endoplasmic reticulum (ER)-resident membrane protein that mediates cytosolic pathogen DNA-induced innate immunity and inflammatory responses in host defenses. STING is activated by cyclic di-nucleotides and is then translocated to the Golgi apparatus, an event that triggers STING assembly with the downstream enzyme TANK-binding kinase 1 (TBK1). This assembly leads to the phosphorylation of the transcription factor interferon regulatory factor 3 (IRF3), which, in turn, induces expression of type-I interferon (IFN) and chemokine genes...
April 4, 2018: Journal of Biological Chemistry
https://www.readbyqxmd.com/read/29616123/overexpression-and-clinical-significance-of-ibp-in-epithelial-ovarian-carcinoma
#10
Yingjuan Xu, Yangming Hou, Tianbo Liu, Ge Lou
Interferon regulatory factor-4 binding protein (IBP) is as a type of ρ GTPase suggested to serve an important role in tumor occurrence and development through the effects of cytoskeletal remodeling, and cell conduction mechanism. IBP is widely expressed in the immune system and expressed in several types of tumors. However, its expression and prognostic value in epithelial ovarian carcinoma (EOC) remain unclear. The present study aimed to investigate the expression of IBP in EOC, and its effect on clinicopathological variables and prognosis...
May 2018: Oncology Letters
https://www.readbyqxmd.com/read/29616030/recognition-of-double-stranded-rna-and-regulation-of-interferon-pathway-by-toll-like-receptor-10
#11
Suki Man-Yan Lee, Tsz-Fung Yip, Sheng Yan, Dong-Yan Jin, Hong-Li Wei, Rey-Ting Guo, Joseph Sriyal Malik Peiris
Toll-like receptor (TLR)-10 remains an orphan receptor without well-characterized ligands or functions. Here, we reveal that TLR10 is predominantly localized to endosomes and binds dsRNA in vitro at endosomal pH, suggesting that dsRNA is a ligand of TLR10. Recognition of dsRNA by TLR10 activates recruitment of myeloid differentiation primary response gene 88 for signal transduction and suppression of interferon regulatory factor-7 dependent type I IFN production. We also demonstrate crosstalk between TLR10 and TLR3, as they compete with each other for dsRNA binding...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29610295/samhd1-suppresses-innate-immune-responses-to-viral-infections-and-inflammatory-stimuli-by-inhibiting-the-nf-%C3%AE%C2%BAb-and-interferon-pathways
#12
Shuliang Chen, Serena Bonifati, Zhihua Qin, Corine St Gelais, Karthik M Kodigepalli, Bradley S Barrett, Sun Hee Kim, Jenna M Antonucci, Katherine J Ladner, Olga Buzovetsky, Kirsten M Knecht, Yong Xiong, Jacob S Yount, Denis C Guttridge, Mario L Santiago, Li Wu
Sterile alpha motif and HD-domain-containing protein 1 (SAMHD1) blocks replication of retroviruses and certain DNA viruses by reducing the intracellular dNTP pool. SAMHD1 has been suggested to down-regulate IFN and inflammatory responses to viral infections, although the functions and mechanisms of SAMHD1 in modulating innate immunity remain unclear. Here, we show that SAMHD1 suppresses the innate immune responses to viral infections and inflammatory stimuli by inhibiting nuclear factor-κB (NF-κB) activation and type I interferon (IFN-I) induction...
April 2, 2018: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/29587798/inhibition-of-peripheral-macrophages-by-nicotinic-acetylcholine-receptor-agonists-suppresses-spinal-microglial-activation-and-neuropathic-pain-in-mice-with-peripheral-nerve-injury
#13
Norikazu Kiguchi, Daichi Kobayashi, Fumihiro Saika, Shinsuke Matsuzaki, Shiroh Kishioka
BACKGROUND: Neuro-immune interaction underlies chronic neuroinflammation and aberrant sensory processing resulting in neuropathic pain. Despite the pathological significance of both neuroinflammation-driven peripheral sensitization and spinal sensitization, the functional relationship between these two distinct events has not been understood. METHODS: In this study, we determined whether inhibition of inflammatory macrophages by administration of α4β2 nicotinic acetylcholine receptor (nAChR) agonists improves neuropathic pain and affects microglial activation in the spinal dorsal horn (SDH) in mice following partial sciatic nerve ligation (PSL)...
March 27, 2018: Journal of Neuroinflammation
https://www.readbyqxmd.com/read/29570417/reduction-of-marek-s-disease-virus-infection-by-toll-like-receptor-ligands-in-chicken-embryo-fibroblast-cells
#14
Jegarubee Bavananthasivam, Raveendra R Kulkarni, Leah Read, Shayan Sharif
Evolutionarily conserved pattern recognition receptors, including Toll-like receptors (TLRs) recognize pathogen-associated molecular patterns (PAMPs) that are present in microbes. PAMPs induce several pathways downstream of TLRs that lead to induction of antiviral responses. The objective of this study was to investigate the stimulatory effect of various PAMPs (in the form of TLR ligands) in reducing Marek's disease virus (MDV) infection in chicken embryo fibroblast cells (CEFs). To this end, CEFs were pretreated with Pam3CSK4, Poly(IC), lipopolysaccharide (LPS), and CpG ODN as TLR2, TLR3, TLR4, and TLR21 ligands, respectively for 24 h followed by infection with MDV...
March 23, 2018: Viral Immunology
https://www.readbyqxmd.com/read/29552184/%C3%AE-%C3%AE-t-cell-mediated-individualized-immunotherapy-for-hepatocellular-carcinoma-considering-clinicopathological-characteristics-and-immunosuppressive-factors
#15
Wei Tian, Jun Ma, Ruyi Shi, Chongren Ren, Jiefeng He, Haoliang Zhao
Hepatocellular carcinoma (HCC) is the most common form of primary liver cancer. γδ T cells have been revealed to be promising candidates for immunotherapy in patients with HCC. However, the use of these cells in clinical practice has been demonstrated to be challenging. In the present study, γδ T cells isolated from the peripheral blood of patients with HCC (n=83) and healthy donors (n=15) were characterized. Flow cytometry was used to analyze the proportion, phenotype, tumor-killing capacity and cytokine secretion of regulatory T cells (Tregs) and γδ T17 cells in peripheral blood samples prior to and following amplification...
April 2018: Oncology Letters
https://www.readbyqxmd.com/read/29549296/mechanical-stretch-induced-transcriptomic-profiles-in-cardiac-myocytes
#16
Jaana Rysä, Heikki Tokola, Heikki Ruskoaho
Mechanical forces are able to activate hypertrophic growth of cardiomyocytes in the overloaded myocardium. However, the transcriptional profiles triggered by mechanical stretch in cardiac myocytes are not fully understood. Here, we performed the first genome-wide time series study of gene expression changes in stretched cultured neonatal rat ventricular myocytes (NRVM)s, resulting in 205, 579, 737, 621, and 1542 differentially expressed (>2-fold, P < 0.05) genes in response to 1, 4, 12, 24, and 48 hours of cyclic mechanical stretch...
March 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29545793/src-family-kinases-regulate-interferon-regulatory-factor-1-k63-ubiquitination-following-activation-by-tlr7-8-vaccine-adjuvant-in-human-monocytes-and-b-cells
#17
Lorenza Tulli, Francesca Cattaneo, Juliette Vinot, Cosima T Baldari, Ugo D'Oro
Toll-like receptors (TLRs) play a key role in the activation of innate immune cells, in which their engagement leads to production of cytokines and co-stimulatory molecules. TLRs signaling requires recruitment of toll/IL-1R (TIR) domain-containing adaptors, such as MyD88 and/or TRIF, and leads to activation of several transcription factors, such as NF-κB, the AP1 complex, and various members of the interferon regulatory factor (IRF) family, which in turn results in triggering of several cellular functions associated with these receptors...
2018: Frontiers in Immunology
https://www.readbyqxmd.com/read/29534658/gene-expression-profile-of-toll-like-receptor-adaptor-interferon-regulatory-factor-cytokine-axis-during-liver-regeneration-after-partial-ischemia-reperfusion-injury
#18
Meysam Nasiri, Mohammad-Hossein Karimi, Negar Azarpira, Iraj Saadat
OBJECTIVES: Toll-like receptors and downstream signal transduction pathways play pivotal roles in induction of inflammation, which is crucial for liver injury and regeneration. MATERIALS AND METHODS: Using a mouse model of partial hepatic ischemia-reperfusion injury followed by a 28-day time course for liver repair and regeneration, we assessed gene expression levels for Toll-like receptors, myeloid differentiation primary response 88, TIR-domain-containing adapter-inducing interferon-β, nuclear factor κB, interferon regulatory factors, tumor necrosis factor-α, and interleukins 1β and 6 at days 1, 4, 7, 14, and 28 after reperfusion in liver and blood cells by quantitative polymerase chain reaction...
March 9, 2018: Experimental and Clinical Transplantation
https://www.readbyqxmd.com/read/29531645/mrna-expression-of-interferon-regulatory-factors-during-acute-rejection-of-liver-transplants-in-patients-with-autoimmune-hepatitis
#19
M Nasiri, B Geramizadeh, S H Nabavizadeh, S A Male-Hosseini, M H Karimi, I Saadat
Background: Interferon regulatory factors (IRFs) can play a critical role in the regulation of many facets of innate and adaptive immune responses through transcriptional activation of type I interferons, other proinflammatory cytokines, and chemokines. However, their roles in transplantation immunity still remain to be elucidated. Objective: To evaluate the time course of mRNA expression of all 9 members of IRFs family of transcription factors during liver allograft acute rejection...
2018: International Journal of Organ Transplantation Medicine
https://www.readbyqxmd.com/read/29496994/fascin1-suppresses-rig-i-like-receptor-signaling-and-interferon-%C3%AE-production-by-associating-with-i%C3%AE%C2%BAb-kinase-%C3%AF%C2%B5-ikk%C3%AF%C2%B5-in-colon-cancer
#20
Tomio Matsumura, Shigeaki Hida, Masato Kitazawa, Chifumi Fujii, Akira Kobayashi, Michiko Takeoka, Shun-Ichiro Taniguchi, Shin-Ichi Miyagawa
Fascin1 is an actin-bundling protein involved in cancer cell migration and has recently been shown also to have roles in virus-mediated immune cell responses. Because viral infection has been shown to activate immune cells and to induce interferon-β expression in human cancer cells, we evaluated the effects of fascin1 on virus-dependent signaling via the membrane- and actin-associated protein RIG-I (retinoic acid-inducible gene I) in colon cancer cells. We knocked down fascin1 expression with shRNA retrovirally transduced into a DLD-1 colon cancer and L929 fibroblast-like cell lines and used luciferase reporter assays and co-immunoprecipitation to identify fascin1 targets...
April 27, 2018: Journal of Biological Chemistry
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